Scholars@Duke
Jonathan Allen Cohn

Jonathan Allen Cohn

Professor of Medicine
Medicine, Gastroenterology
jonathan.cohn@duke.edu
DUMC Box 3256, Durham, NC 27710
GSRB-1 Room 2038, 905 S LaSalle St, Durham, NC 27710

Featured Works

Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations.

Journal article Gastroenterology · December 2001 Featured Publication BACKGROUND & AIMS: Nonalcoholic chronic pancreatitis is usually idiopathic and often associated with cystic fibrosis gene (CFTR) mutations. It is unknown whether pancreatitis risk correlates with having 1 or 2 CFTR mutations, abnormal epithelial ion transp ... Full text Link to item Cite

Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.

Journal article N Engl J Med · September 3, 1998 Featured Publication BACKGROUND: It is unknown whether genetic factors predispose patients to idiopathic pancreatitis. In patients with cystic fibrosis, mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene typically cause pulmonary and pancreatic in ... Full text Link to item Cite

CFTR as a cAMP-dependent regulator of sodium channels.

Journal article Science · August 11, 1995 Featured Publication Cystic fibrosis transmembrane regulator (CFTR), the gene product that is mutated in cystic fibrosis (CF) patients, has a well-recognized function as a cyclic adenosine 3',5'-monophosphate (cAMP)-regulated chloride channel, but this property does not accoun ... Full text Link to item Cite

Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells.

Journal article Gastroenterology · December 1993 Featured Publication BACKGROUND: Liver dysfunction is a common manifestation of cystic fibrosis (CF), a disease caused by mutations affecting the CF transmembrane conductance regulator (CFTR). The aim of this study was to examine the distribution and role of CFTR in liver. MET ... Full text Link to item Cite

Regulation of membrane chloride currents in rat bile duct epithelial cells.

Journal article J Clin Invest · January 1993 Featured Publication This study examines the conductive properties of the plasma membrane of cells isolated from the intrahepatic portion of bile ducts. Membrane Cl- conductance was measured in single cells using whole-cell patch clamp recording techniques and in cells in shor ... Full text Link to item Cite

Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line.

Journal article Proc Natl Acad Sci U S A · March 15, 1992 Featured Publication An anti-peptide antibody raised to the C-terminal sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) was used to examine CFTR immunoreactivity in the T84 colonocyte cell line. Immunoblots of T84 cell lysates detected CFTR as a 170-k ... Full text Link to item Cite

Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.

Journal article J Clin Invest · August 1991 Featured Publication Cystic fibrosis (CF) is characterized by an abnormality in cAMP-regulated chloride transport that results from a primary defect in the protein product of the CF gene, the CF transmembrane conductance regulator (CFTR). In this report, antibodies against CFT ... Full text Link to item Cite