Scholars@Duke
Jonathan Paul Piccini Sr.

Jonathan Paul Piccini Sr.

Ursula Geller Distinguished Professor of Research in Cardiovascular Diseases
Medicine, Cardiology
jonathan.piccini@duke.edu
Duke Box 31115, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Scholarly Works

Preclinical evaluation of a novel 8-spline pulsed field ablation system.

Journal article Heart Rhythm · July 2026 BACKGROUND: Pulsed field ablation (PFA) technologies offer the potential for improved procedural efficacy and safety. Circumferential pulmonary vein (PV) ablation approaches are attractive compared with point-by-point, simplifying workflow. OBJECTIVE: We e ... Full text Link to item Cite

Impact of atrial fibrillation burden on quality of life and prediction of health care utilization: Primary results from the DEFINE AFib study.

Journal article Heart Rhythm · July 2026 BACKGROUND: Atrial fibrillation (AF) can lead to significant cardiovascular events and health care utilization. Continuous monitoring via insertable cardiac monitors (ICMs) and data analytics have the potential to improve care delivery. OBJECTIVE: The DEFI ... Full text Link to item Cite

Clinical Patterns and Appropriateness of Apixaban Dosing in Patients With Atrial Fibrillation.

Journal article JACC Adv · June 29, 2026 BACKGROUND: Apixaban is a direct oral anticoagulant for stroke prevention in patients with atrial fibrillation (AF) or atrial flutter (AFL), with dose reduction being recommended based on age, body weight, and creatinine. OBJECTIVES: The objective of the s ... Full text Link to item Cite

Same-Day Discharge in Ventricular Ablation: Safety Outcomes and Case Selection.

Journal article J Cardiovasc Electrophysiol · June 15, 2026 INTRODUCTION: Catheter ablation (CA) of ventricular arrhythmias (VA) has traditionally entailed an overnight stay, and little has been published on outcomes of same-day discharge (SDD) in this population. Thus far, no comparative study of SDD in VA ablatio ... Full text Link to item Cite

Pulsed field ablation for the interventional treatment of atrial fibrillation: a scientific statement of the European Heart Rhythm Association of the European Society of Cardiology, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.

Journal article Europace · June 2, 2026 Pulsed field ablation has emerged as a novel non-thermal treatment modality with a distinct safety profile for the interventional treatment of atrial fibrillation. By inducing irreversible electroporation, pulsed field ablation achieves myocardial ablation ... Full text Link to item Cite

Human use conditions in fatigue of intravenous leads used in cardiac implanted electronic devices.

Journal article Heart Rhythm · June 2026 BACKGROUND: Transvenous lead conductors are subject to fatigue fracture from repetitive bending stresses, which are proportional to alternating curvature. A prerequisite for developing a valid preclinical lead-testing standard is knowledge of the stresses ... Full text Link to item Cite

Centers of Excellence Optimal Management Pathways for Atrial Fibrillation Specialty Services (COMPASS) early rhythm control treatment care pathway: A quality improvement initiative.

Journal article Heart Rhythm O2 · June 2026 BACKGROUND: Early rhythm control improves cardiovascular outcomes in recently diagnosed atrial fibrillation (AF) patients. Whether care pathways are a tool to improve translation into clinical practice needs evaluation. OBJECTIVE: The Centers of Excellence ... Full text Link to item Cite

Safety and effectiveness of transvenous extraction for ePTFE-coated leads: A retrospective comparative study.

Journal article Heart Rhythm · May 30, 2026 BACKGROUND: The Heart Rhythm Society statement on the Reliance high-impedance advisory recommended shared decision making regarding lead management decisions given concerns of risk associated with extraction from long dwell times and calcification. OBJECTI ... Full text Link to item Cite

Predictors of ischemic stroke and major bleeding among patients with atrial fibrillation in clinical practice.

Journal article Am Heart J · May 19, 2026 BACKGROUND: Numerous risk scores exist to quantify the risk of ischemic stroke risk in patients with atrial fibrillation or flutter (AF/AFL). However, how these tools perform in cohorts or those already on oral anticoagulation (OAC) therapy is unclear. MET ... Full text Link to item Cite

Dual-chamber pacing from a single leadless device: Preclinical implant and retrieval feasibility study.

Journal article Heart Rhythm · April 29, 2026 BACKGROUND: Sequential atrioventricular pacing can be accomplished with separate atrial and ventricular devices. Integration of atrial and ventricular pacing within a single leadless device represents a novel approach to dual-chamber pacing (DDD). OBJECTIV ... Full text Link to item Cite

Patient Care Pathways and Outcomes Following Newly Diagnosed Atrial Fibrillation.

Journal article J Am Heart Assoc · April 7, 2026 BACKGROUND: Care pathways for patients with atrial fibrillation (AF) are poorly understood and may influence the likelihood of guideline concordant oral anticoagulation or antiarrhythmic drug therapy and associated outcomes. METHODS: Adult patients in the ... Full text Link to item Cite

Self-Administered Etripamil Nasal Spray Slows Ventricular Rate in Patients With Atrial Fibrillation: A Post Hoc Analysis of the NODE-303 Study.

Journal article J Cardiovasc Electrophysiol · April 2026 INTRODUCTION: Currently, there are no available fast-acting agents to control the ventricular rate (VR) during atrial fibrillation (AF) episodes that can be self-administered by patients on an as-needed basis without medical supervision. Here, we aim to ev ... Full text Link to item Cite

Left atrial appendage occlusion and concomitant catheter ablation procedures.

Journal article Heart Rhythm · March 10, 2026 BACKGROUND: The safety and effectiveness of concomitant catheter ablation at the time of left atrial appendage (LAA) occlusion (LAAO) are not well characterized. OBJECTIVE: This study aimed to describe the safety and effectiveness of LAAO during concomitan ... Full text Link to item Cite

A randomized controlled trial of pulsed field ablation vs antiarrhythmic therapy as a first-line treatment for persistent atrial fibrillation: The AVANT GUARD trial rationale and design.

Journal article Heart Rhythm O2 · March 2026 BACKGROUND: Recent studies have established catheter ablation as a safe and superior alternative to antiarrhythmic drugs (AADs) as a first-line therapy in patients with paroxysmal atrial fibrillation (AF). There are no randomized controlled trials assessin ... Full text Link to item Cite

Sex-Based Differences in Left Bundle Branch Capture During Left Bundle Branch Area Pacing.

Journal article Pacing Clin Electrophysiol · February 25, 2026 OBJECTIVE: To identify sex-based differences in meeting left bundle branch (LBB) capture criteria on postimplant ECGs. BACKGROUND: Despite differences in QRS duration (QRSd) between males and females, no sex-based criteria have been established for definin ... Full text Link to item Cite

Outcomes in Patients With Atrial Fibrillation Stratified by Body Mass Index and Heart Failure Status.

Journal article JACC Adv · February 2026 BACKGROUND: An obesity-survival benefit, called the "obesity paradox," has been variably reported in patients with heart failure (HF) and those with atrial fibrillation (AF), but inconsistencies have been observed. OBJECTIVES: The purpose of this study was ... Full text Link to item Cite

Management of atrial fibrillation in patients with heart failure with preserved ejection fraction.

Journal article Heart Fail Rev · December 2025 Atrial fibrillation (AF) and heart failure with a preserved ejection fraction (HFpEF) frequently co-exist and are associated with high cardiovascular morbidity and mortality. The management of AF in HFpEF requires a multifaceted and integrated approach tha ... Full text Link to item Cite

Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism.

Journal article Nat Rev Cardiol · November 2025 Therapeutic anticoagulation is essential to prevent and treat venous and arterial thromboembolism. The available agents target coagulation factors involved in thrombus formation but are associated with an increased risk of bleeding. Factor XI plays a minor ... Full text Link to item Cite

Microbubble and thermal profile of an eight-spline pulsed field ablation system in a pre-clinical model.

Journal article J Interv Card Electrophysiol · October 16, 2025 BACKGROUND: Pulsed field ablation (PFA) has become a clinically accepted energy modality for catheter ablation of atrial fibrillation. As PFA catheters improve and evolve, iatrogenic cerebral events remain an important consideration when evaluating the saf ... Full text Link to item Cite

Utilisation of ambulatory ECG monitoring for prediction of heart failure and stroke events and healthcare expenditure in treated and untreated patients: a retrospective cohort study.

Journal article BMJ Open · September 22, 2025 OBJECTIVE: We evaluated the performance of risk models that incorporate ambulatory ECG data and clinical information for prediction of healthcare expenditures related to heart failure (HF) and stroke events in treated and untreated patients. DESIGN AND SET ... Full text Link to item Cite

An international physician survey of current ablation practices in atrial fibrillation: An AIM-AF substudy.

Journal article Heart Rhythm · September 2025 BACKGROUND: Practice guidelines recommend ablation (ABL) in atrial fibrillation (AF) for rhythm control. Guidance for antiarrhythmic drugs (AADs) post-ABL is limited. OBJECTIVE: The purpose of this study was to determine AAD and ABL practices in the United ... Full text Link to item Cite

Complications associated with pulsed field ablation vs radiofrequency catheter ablation of atrial fibrillation.

Journal article Heart Rhythm · September 2025 BACKGROUND: The first commercial systems for pulsed field ablation (PFA) were recently approved by the Food and Drug Administration, but their safety profile in nationwide practice remains underexplored. OBJECTIVES: This study aimed to describe reported ad ... Full text Link to item Cite

An External Control Arm for the Oral Factor XIa Inhibitor Asundexian Phase 2 Trial in Atrial Fibrillation (PACIFIC-AF) Using Electronic Health Records.

Journal article Cardiol Ther · September 2025 INTRODUCTION: The aim of this study was to assess the applicability of an external control arm (ECA) approach in the clinical development of the oral factor XIa inhibitor asundexian for stroke prevention in patients with atrial fibrillation (AF), using pro ... Full text Link to item Cite

Catheter ablation vs antiarrhythmic drug therapy for first-line treatment of atrial fibrillation in United States clinical practice.

Journal article Heart Rhythm · August 14, 2025 BACKGROUND: Catheter ablation (CA) has a Class I indication for first-line rhythm control for atrial fibrillation (AF). OBJECTIVE: This study aimed to compare the safety and effectiveness of CA vs antiarrhythmic drug (AAD) for first-line rhythm control the ... Full text Link to item Cite

Impact of timing of treatment for cardiac implantable electronic device infections on healthcare utilization and expenditures.

Journal article Europace · August 4, 2025 AIMS: Early extraction for cardiovascular implantable electronic device (CIED) infections has been associated with longer survival, while the impact on healthcare utilization is unknown. The aim is to evaluate the impact of early extraction on healthcare e ... Full text Link to item Cite

Transvenous extraction of quadripolar coronary sinus pacing leads.

Journal article Heart Rhythm · August 2025 BACKGROUND: Quadripolar coronary sinus (CS) leads are commonly employed to achieve left ventricular pacing. There are limited data on extraction of these leads relative to traditional unipolar or bipolar CS pacing leads. OBJECTIVE: The purpose of this stud ... Full text Link to item Cite

Atrioventricular Synchrony Algorithm Modeling of a Leadless Pacemaker Family: A Virtual Patient Analysis.

Journal article Cardiovasc Eng Technol · August 2025 PURPOSE: To assess the impact of enhancements to the Atrioventricular Synchrony (AVS) algorithms of a next generation Micra leadless pacemaker (Micra AV2). METHODS: Accelerometer data were extracted from the AccelAV clinical study and were used to create v ... Full text Link to item Cite

Antiarrhythmic drug use in atrial fibrillation among different European countries - as determined by a physician survey.

Journal article Int J Cardiol Heart Vasc · August 2025 BACKGROUND: There is limited knowledge of physicians' antiarrhythmic drug (AAD) treatment practices for patients with atrial fibrillation and adherence to guidelines in European countries. METHODS: An online survey (n = 321) of cardiologists, cardiac elect ... Full text Link to item Cite

Characterizing the recurrence of atrial arrhythmia following macro-reentrant atrial tachycardia ablation in adult patients with repaired tetralogy of Fallot.

Journal article Heart Rhythm O2 · August 2025 BACKGROUND: The recurrence of arrhythmia following catheter ablation of macro-reentrant atrial tachycardia (MRAT) in repaired tetralogy of Fallot (rTOF) is poorly understood. OBJECTIVE: To better describe the incidence, mechanisms, and predictors of recurr ... Full text Link to item Cite

Device longevity of a leadless pacemaker family.

Journal article Future Cardiol · August 2025 BACKGROUND: Leadless ventricular pacemakers have been developed for single chamber VVIR and AV synchronous pacing applications. AIM: To assess the device longevity impact of battery/electronics enhancements of next-generation Micra leadless pacemakers, Mic ... Full text Link to item Cite

Imaging findings associated with costoclavicular intervention during lead extraction.

Journal article Heart Rhythm · July 2025 BACKGROUND: Binding sites in the costoclavicular space are commonly encountered during transvenous lead extraction. Severe adhesions may warrant use of more aggressive rotational cutting tools or surgical intervention. It is not known whether preprocedural ... Full text Link to item Cite

Characterization of Septal Scar After Left Bundle Branch Area Pacemaker Implantation.

Journal article Pacing Clin Electrophysiol · July 2025 BACKGROUND: Left bundle branch area pacing (LBBAP) is increasingly used in patients with a ventricular pacing indication but necessitates precise septal localization. The resulting effects of intraoperative lead repositioning on septal fibrosis remain unkn ... Full text Link to item Cite

Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use: A Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial.

Journal article JAMA Cardiol · June 1, 2025 IMPORTANCE: In patients with atrial fibrillation (AF), oral anticoagulants (OACs) reduce the risk of stroke. OBJECTIVE: To investigate if patients with less prior OAC exposure respond differently to a new OAC than patients with more OAC exposure. DESIGN, S ... Full text Link to item Cite

Sotalol Dosing and Outcomes Among Patients Undergoing Intravenous Loading for Atrial Arrhythmias-A PEAKS Registry Substudy.

Journal article J Cardiovasc Electrophysiol · June 2025 BACKGROUND: Sotalol is used for the maintenance of sinus rhythm among patients with atrial fibrillation. However, there is discretion regarding dosing of chronic therapy, and the target oral dose dictates infusion doses for intravenous sotalol loading. To ... Full text Link to item Cite

Incidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019.

Journal article Circ Cardiovasc Qual Outcomes · May 2025 BACKGROUND: Atrial fibrillation (AF) is known to be associated with increased risks of stroke and death, but contemporary studies of this association are lacking. We evaluated trends in stroke and death among Medicare beneficiaries with AF between 2013 and ... Full text Link to item Cite

Noninvasive Hemodynamic Assessment by a Sensor Patch: The PATCHWRK (PortAble TeCHnology for Wireless caRdiomyopathy tracKing) Study.

Journal article JACC Adv · May 2025 BACKGROUND: Echocardiographic timing intervals provide prognostic information in patients with preclinical cardiac dysfunction. Reduced diastolic filling time (DFT) identifies left bundle branch block patients at risk for cardiomyopathy. The need for speci ... Full text Link to item Cite

Symptoms Burden as a Clinical Outcomes Assessment in Heart Failure Patients With Atrial Fibrillation.

Journal article JACC Heart Fail · April 2025 BACKGROUND: Safe and effective pharmacologic therapy for atrial fibrillation (AF) in heart failure (HF) is an unmet need. In AF clinical trials, the standard primary endpoint of time to first symptomatic AF event (TTFSE) has several disadvantages, which co ... Full text Link to item Cite

Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias.

Journal article CPT Pharmacometrics Syst Pharmacol · April 2025 Sotalol, a class III antiarrhythmic agent, is used to maintain sinus rhythm in patients with atrial fibrillation or atrial flutter (AFIB/AFL). Despite its efficacy, sotalol's use is limited by its potential to cause life-threatening ventricular arrhythmias ... Full text Link to item Cite

Use of a Stylet Driven Lead With a Flexible Neck for Left Bundle Branch Area Pacing: A Single Center Experience.

Journal article J Cardiovasc Electrophysiol · April 2025 BACKGROUND: The majority of data on left bundle branch area pacing (LBBAP) are on a lumenless lead. Data on the safety and effectiveness of stylet driven leads are comparatively lacking. METHODS: We retrospectively analyzed 265 patients who underwent attem ... Full text Link to item Cite

Correlation between mobile and 12-lead ECG among patients loading with intravenous sotalol: A PEAKS substudy.

Journal article Heart Rhythm O2 · April 2025 BACKGROUND: Electrocardiographic monitoring is performed during sotalol loading, primarily to assess QTc. Continuous telemetry increases resource utilization, generating interest in streamlining QTc monitoring through mobile technologies. OBJECTIVE: Assess ... Full text Link to item Cite

Dronedarone provides effective early rhythm control: post-hoc analysis of the ATHENA trial using EAST-AFNET 4 criteria.

Journal article Europace · March 28, 2025 AIMS: This post-hoc analysis of the ATHENA trial assessed whether dronedarone (400 mg twice daily) improved cardiovascular outcomes compared with placebo in patients with early atrial fibrillation/atrial flutter (AF) and cardiovascular comorbidities, based ... Full text Link to item Cite

ACC/AHA/ASE/HFSA/HRS/SCAI/SCCT/SCMR 2025 Appropriate Use Criteria for Implantable Cardioverter-Defibrillators, Cardiac Resynchronization Therapy, and Pacing.

Journal article J Am Coll Cardiol · March 25, 2025 This appropriate use criteria (AUC) document is developed by the American College of Cardiology along with key specialty and subspecialty societies. It provides a comprehensive review of common clinical scenarios where implantable cardioverter-defibrillato ... Full text Link to item Cite

Care for Atrial Fibrillation and Outcomes in Rural Versus Urban Communities in the United States: A Systematic and Narrative Review.

Journal article J Am Heart Assoc · March 4, 2025 Atrial fibrillation (AF) is the most common sustained arrhythmia and associated with increased morbidity and mortality. Differences have been identified between medical care delivered in urban and rural settings, and rurality-based disparities may exist in ... Full text Link to item Cite

Cardioneuroablation for the management of patients with recurrent vasovagal syncope and symptomatic bradyarrhythmias: the CNA-FWRD Registry.

Journal article J Interv Card Electrophysiol · March 2025 BACKGROUND: Cardioneuroablation has been emerging as a potential treatment alternative in appropriately selected patients with cardioinhibitory vasovagal syncope (VVS) and functional AV block (AVB). However the majority of available evidence has been deriv ... Full text Link to item Cite

Impact of race and ethnicity on the rhythm control of newly diagnosed atrial fibrillation: Insights from the Get With the Guidelines Atrial Fibrillation Registry.

Journal article Heart Rhythm · March 2025 BACKGROUND: An early rhythm control strategy is the preferred management for patients newly diagnosed with atrial fibrillation (AF). A rhythm control strategy, however, has been historically underused for patients from underrepresented racial and ethnic gr ... Full text Link to item Cite

Long-term management of leadless pacemakers.

Journal article Eur Heart J Suppl · March 2025 Leadless pacemakers (LPs) are increasingly being used to treat bradyarrhythmias, and end of service (EOS) management decisions are becoming increasingly important given finite battery lifespans. Two strategies have been adopted for device EOS: LP abandonme ... Full text Link to item Cite

Stroke-bleeding risk score pairings within individuals in the outcomes registry for better informed treatment of atrial fibrillation (ORBIT-AF) registry.

Journal article Int J Cardiol · February 15, 2025 BACKGROUND: Decisions about stroke prevention strategies in atrial fibrillation (AF) typically balance thromboembolism reduction against increased bleeding from oral anticoagulation therapy (OAC). When determining eligibility for OAC, guidelines recommend ... Full text Link to item Cite

Ineffective cardiac resynchronization pacing is associated with poor outcomes in a nationwide cohort analysis.

Journal article Heart Rhythm · February 2025 BACKGROUND: Delivery of cardiac resynchronization therapy (CRT) requires left ventricular myocardial capture to achieve clinical benefits. OBJECTIVE: We sought to determine whether ineffective pacing affects survival. METHODS: Ineffective ventricular pacin ... Full text Link to item Cite

Appropriate and inappropriate ICD shocks in patients with LVADs: Prevalence, associated factors, and etiologies.

Journal article Heart Rhythm · February 2025 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are a common complication after left ventricular assist device (LVAD) implantation; however, data on their frequency and causes are limited. OBJECTIVE: The purpose of this study was to define ... Full text Link to item Cite

Factors associated with stellate ganglion block success in recurrent ventricular arrhythmias.

Journal article ESC Heart Fail · February 2025 AIMS: One treatment option for refractory ventricular arrythmias is stellate ganglion block (SGB). We examined differences in SGB success by patient and arrhythmia characteristics and predictors of successful SGB. METHODS AND RESULTS: This was a multicente ... Full text Link to item Cite

Meta-Analysis of Renal Denervation Therapy During Pulmonary Vein Isolation in Atrial Fibrillation.

Journal article Am J Cardiol · February 1, 2025 Pulmonary vein isolation (PVI) has been established as a first-line therapy for symptomatic atrial fibrillation (AF) in selected patients with symptomatic AF and in those whose antiarrhythmic drug treatment failed. However, AF recurrence rates after PVI re ... Full text Link to item Cite

Asundexian versus Apixaban in Patients with Atrial Fibrillation.

Journal article N Engl J Med · January 2, 2025 BACKGROUND: Stroke prevention with direct-acting oral anticoagulant agents in patients with atrial fibrillation confers a risk of bleeding and limits their use. Asundexian, an activated factor XI (XIa) inhibitor, is an oral anticoagulant that may prevent s ... Full text Link to item Cite

Atrial Fibrillation and Retinal Stroke.

Journal article JAMA Netw Open · January 2, 2025 IMPORTANCE: Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It is not known whether AF is independently associated with increased risk of retinal stroke (central retinal artery occlusion), a subtype of ischemic s ... Full text Link to item Cite

Design and rationale of a pragmatic randomized clinical trial of early dronedarone versus usual care to change and improve outcomes in persons with first-detected atrial fibrillation - the CHANGE AFIB study.

Journal article Am Heart J · January 2025 BACKGROUND: While there are several completed clinical trials that address treatment strategies in patients with symptomatic and recurrent atrial fibrillation (AF), there are no randomized clinical trials that address first-line rhythm control of new-onset ... Full text Link to item Cite

Characterization and Localization of Focal Atrial Tachycardia in Patients With Adult Congenital Heart Disease.

Journal article JACC Clin Electrophysiol · January 2025 BACKGROUND: In patients with structurally normal hearts, algorithms using surface electrocardiographic P-wave morphology are helpful to predict focal atrial tachycardia (FAT) location. However, these algorithms have not been formally assessed in patients w ... Full text Link to item Cite

Racial and Ethnic Disparities in the Use and Outcomes With WATCHMAN FLX: A SURPASS Analysis of the NCDR Left Atrial Appendage Occlusion Registry.

Journal article J Am Heart Assoc · December 3, 2024 BACKGROUND: Left atrial appendage occlusion (LAAO) is increasingly used as an alternative to oral anticoagulation for stroke prevention in select patients with atrial fibrillation. Data on outcomes in racial and ethnic minority individuals are limited. Thi ... Full text Link to item Cite

Effect of implantable loop recorder-based continuous rhythm monitoring on incident atrial fibrillation and stroke: An updated systematic review and meta-analysis of randomized controlled trials.

Journal article Heart Rhythm · December 2024 BACKGROUND: In patients with a history of stroke or those at high risk for developing stroke, a continuous rhythm monitoring strategy using an implantable loop recorder (ILR) is often performed to screen for atrial fibrillation (AF). OBJECTIVES: The purpos ... Full text Link to item Cite

Transvenous extraction of conduction system and lumenless pacing leads.

Journal article J Cardiovasc Electrophysiol · December 2024 INTRODUCTION: Conduction system pacing (CSP), often accomplished with lumenless pacing leads, is increasingly employed to achieve physiologic ventricular activation. There are limited data on the extraction of these leads. The objective of this study was t ... Full text Link to item Cite

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.

Journal article J Arrhythm · December 2024 In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare p ... Full text Link to item Cite

Use of continuous cardiac monitoring to assess the influence of atrial fibrillation burden and patterns on patient symptoms and healthcare utilization: The DEFINE AFib study.

Journal article Heart Rhythm O2 · December 2024 BACKGROUND: Atrial fibrillation (AF) has a significant impact on health and quality of life. The relationship of AF burden and temporal patterns of AF on patient symptoms, outcomes, and healthcare utilization is unknown. Insertable cardiac monitors (ICMs) ... Full text Link to item Cite

Assessment of Antitachycardia Pacing in Primary Prevention Patients: The APPRAISE ATP Randomized Clinical Trial.

Journal article JAMA · November 26, 2024 IMPORTANCE: The emergence of novel programming guidelines that reduce premature and inappropriate therapies along with the availability of new implantable cardioverter-defibrillator (ICD) technologies lacking traditional endocardial antitachycardia pacing ... Full text Link to item Cite

Technologic Advances in Cardiac Electrophysiology.

Journal article Circulation · November 26, 2024 Full text Link to item Cite

Discordant Treatment Goals for Patients With Atrial Fibrillation and Clinical Trials Metrics.

Journal article JACC Clin Electrophysiol · November 2024 BACKGROUND: Most clinical trials define successful atrial fibrillation (AF) treatment as no AF episodes longer than 30 seconds. Yet, there has been minimal study of how patients define successful treatment and whether their perspectives align with trial ou ... Full text Link to item Cite

Temporal changes in device-derived daily activity related to ventricular arrhythmias from the CERTITUDE registry.

Journal article Heart Rhythm O2 · November 2024 BACKGROUND: There have been limited data examining the temporal relationship between device-derived daily activity and ventricular arrhythmias (VAs). OBJECTIVE: We aimed to assess whether activity predicted VAs or VAs predicted changes in activity. METHODS ... Full text Link to item Cite

Performance of Ambulatory Electrocardiographic Data for Prediction of Stroke and Heart Failure Events.

Journal article JACC Adv · November 2024 BACKGROUND: Despite clear associations between arrhythmia burden and cardiovascular risk, clinical risk scores that predict cardiovascular events do not incorporate individual-level arrhythmia characteristics from long-term continuous monitoring (LTCM). OB ... Full text Link to item Cite

Using Atrial Fibrillation Burden Trends and Machine Learning to Predict Near-Term Risk of Cardiovascular Hospitalization.

Journal article Circ Arrhythm Electrophysiol · November 2024 BACKGROUND: Atrial fibrillation is associated with an increased risk of cardiovascular hospitalization (CVH), which may be triggered by changes in daily burden. Machine learning of dynamic trends in atrial fibrillation burden, as measured by insertable car ... Full text Link to item Cite

Performance of Atrial Fibrillation Burden Trends for Stroke Risk Stratification.

Journal article Circ Arrhythm Electrophysiol · November 2024 BACKGROUND: Atrial fibrillation (AF) is associated with an increased risk of stroke, yet the limitations of conventional monitoring have restricted our understanding of AF burden risk thresholds. Predictive algorithms incorporating continuous AF burden mea ... Full text Link to item Cite

Two-year outcomes of Micra AV leadless pacemakers in the Micra AV CED study.

Journal article Europace · November 1, 2024 AIMS: Leadless pacing is a safe and effective alternative to transvenous pacing for bradycardia. Micra AV is a leadless, single-device solution that provides atrioventricular synchronous ventricular pacing therapy. Early results from the Micra AV CED study ... Full text Link to item Cite

A leadless ventricular pacemaker providing atrioventricular synchronous pacing in the real-world setting: 12-Month results from the Micra AV post-approval registry.

Journal article Heart Rhythm · October 2024 BACKGROUND: Advances in leadless pacemaker technology have enabled accelerometer-based atrioventricular (AV) synchronous pacing by sensing atrial mechanical contraction. OBJECTIVE: The purpose of this study was to report the performance of the Micra AV lea ... Full text Link to item Cite

Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion.

Journal article J Am Coll Cardiol · September 3, 2024 BACKGROUND: The prevalence of and outcomes associated with different antithrombotic strategies after left atrial appendage occlusion (LAAO) are not well described. OBJECTIVES: This study sought to evaluate patterns of antithrombotic medication strategies a ... Full text Link to item Cite

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.

Journal article Heart Rhythm · September 2024 In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare p ... Full text Link to item Cite

Association between COVID-19 vaccination and atrial arrhythmias in individuals with cardiac implantable electronic devices.

Journal article J Cardiovasc Electrophysiol · September 2024 INTRODUCTION: The impact of mRNA-based coronavirus disease-2019 (COVID-19) vaccines on atrial arrhythmias (AA) and ventricular arrhythmias incidence is unknown. METHODS: BIOTRONIK Home Monitoring data and Medicare Claims data were utilized to identify indi ... Full text Link to item Cite

Outcomes With the WATCHMAN FLX in Everyday Clinical Practice From the NCDR Left Atrial Appendage Occlusion Registry.

Journal article Circ Cardiovasc Interv · September 2024 BACKGROUND: PINNACLE FLX (Protection Against Embolism for Nonvalvular AF Patients: Investigational Device Evaluation of the WATCHMAN FLX LAA Closure Technology) demonstrated improved outcomes and low incidence of adverse events with the WATCHMAN FLX device ... Full text Link to item Cite

Predictors of Shock-Reduction Programming and Its Impact on Implantable Cardioverter-Defibrillator Therapies and Mortality: The CERTITUDE Registry.

Journal article J Am Heart Assoc · August 6, 2024 BACKGROUND: Shock-reduction implantable cardioverter-defibrillator programming (SRP) was associated with fewer therapies and improved survival in randomized controlled trials, but real-world studies investigating SRP and associated outcomes are limited. ME ... Full text Link to item Cite

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.

Journal article J Interv Card Electrophysiol · August 2024 In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare p ... Full text Link to item Cite

Machine Learning of Cardiac Anatomy and the Risk of New-Onset Atrial Fibrillation After TAVR.

Journal article JACC Clin Electrophysiol · August 2024 BACKGROUND: New-onset atrial fibrillation (NOAF) occurs in 5% to 15% of patients who undergo transfemoral transcatheter aortic valve replacement (TAVR). Cardiac imaging has been underutilized to predict NOAF following TAVR. OBJECTIVES: The objective of thi ... Full text Link to item Cite

Expedited loading with intravenous sotalol is safe and feasible-primary results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry.

Journal article Heart Rhythm · July 2024 BACKGROUND: Loading of oral sotalol for atrial fibrillation requires 3 days, frequently in the hospital, to achieve steady state. The Food and Drug Administration approved loading with intravenous (IV) sotalol through model-informed development, without pa ... Full text Link to item Cite

Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis.

Journal article J Am Heart Assoc · June 4, 2024 BACKGROUND: Days alive out of hospital (DAOH) is an objective and patient-centered net benefit end point. There are no assessments of DAOH in clinical trials of interventions for atrial fibrillation (AF), and it is not known whether this end point is of cl ... Full text Link to item Cite

Women Trainees in Electrophysiology and the Effect of Role Models.

Journal article Circ Arrhythm Electrophysiol · June 2024 Full text Link to item Cite

Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion.

Journal article Circ Cardiovasc Interv · June 2024 BACKGROUND: Procedure volumes are associated with outcomes for many cardiovascular procedures, leading to guidelines on minimum volume thresholds for certain procedures; however, the volume-outcome relationship with left atrial appendage occlusion is poorl ... Full text Link to item Cite

Association Between Sleep Apnea Treatment and Health Care Resource Use in Patients With Atrial Fibrillation.

Journal article J Am Heart Assoc · May 7, 2024 BACKGROUND: Obstructive sleep apnea (OSA) contributes to the generation, recurrence, and perpetuation of atrial fibrillation, and it is associated with worse outcomes. Little is known about the economic impact of OSA therapy in atrial fibrillation. This re ... Full text Link to item Cite

Peak frequency mapping of atypical atrial flutter.

Journal article J Cardiovasc Electrophysiol · May 2024 INTRODUCTION: Peak frequency (PF) mapping is a novel method that may identify critical portions of myocardial substrate supporting reentry. The aim of this study was to describe and evaluate PF mapping combined with omnipolar voltage mapping in the identif ... Full text Link to item Cite

Prognostic Impact of Sinus Rhythm in Atrial Fibrillation Patients: Separating Rhythm Outcomes From Randomized Strategy Findings From the CABANA Trial.

Journal article Circ Arrhythm Electrophysiol · May 2024 BACKGROUND: Clinically detected atrial fibrillation (AF) is associated with a significant increase in mortality and other adverse cardiovascular events. Since the advent of effective methods for AF rhythm control, investigators have attempted to determine ... Full text Open Access Link to item Cite

Efficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation.

Journal article JACC Clin Electrophysiol · May 2024 BACKGROUND: Postoperative atrial fibrillation (POAF) is associated with increased morbidity and mortality. Epicardial injection of botulinum toxin may suppress POAF. OBJECTIVES: This study sought to assess the safety and efficacy of AGN-151607 for the prev ... Full text Link to item Cite

Leadless pacemakers at 5-year follow-up: the Micra transcatheter pacing system post-approval registry.

Journal article Eur Heart J · April 7, 2024 BACKGROUND AND AIMS: Prior reports have demonstrated a favourable safety and efficacy profile of the Micra leadless pacemaker over mid-term follow-up; however, long-term outcomes in real-world clinical practice remain unknown. Updated performance of the Mi ... Full text Link to item Cite

Repeat catheter ablation for atrial fibrillation.

Journal article Heart Rhythm · April 2024 Catheter ablation of atrial fibrillation (AF) is an established therapy that reduces AF burden, improves quality of life, and reduces the risks of cardiovascular outcomes. Although there are clear guidelines for the application of de novo catheter ablation ... Full text Link to item Cite

Regional differences in outcomes with ablation versus drug therapy for atrial fibrillation: Results from the CABANA trial.

Journal article Am Heart J · April 2024 BACKGROUND: The finding of unexpected variations in treatment benefits by geographic region in international clinical trials raises complex questions about the interpretation and generalizability of trial findings. We observed such geographical variations ... Full text Open Access Link to item Cite

A Multicenter Study of Stellate Ganglion Block as a Temporizing Treatment for Refractory Ventricular Arrhythmias.

Journal article JACC Clin Electrophysiol · April 2024 BACKGROUND: Ventricular tachycardia (VT) and ventricular fibrillation (VF) are life-threatening conditions and can be refractory to conventional drug and device interventions. Stellate ganglion blockade (SGB) has been described as an adjunct, temporizing i ... Full text Link to item Cite

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.

Journal article Europace · March 30, 2024 In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare p ... Full text Link to item Cite

Bleeding Outcomes in Patients Treated With Asundexian in Phase II Trials.

Journal article J Am Coll Cardiol · February 13, 2024 BACKGROUND: Phase II trials of asundexian were underpowered to detect important differences in bleeding. OBJECTIVES: The goal of this study was to obtain best estimates of effects of asundexian vs active control/placebo on major and clinically relevant non ... Full text Link to item Cite

Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study.

Journal article Europace · February 1, 2024 AIMS: Different disease processes can combine to cause atrial fibrillation (AF). Their contribution to recurrent AF after ablation in patients is not known. Cardiovascular processes associated with recurrent AF after AF ablation were determined by quantify ... Full text Link to item Cite

A pilot study of longitudinal changes in neurocognition, white matter hyperintensities, and cortical thickness in atrial fibrillation patients following catheter ablation vs medical management.

Journal article Heart Rhythm O2 · February 2024 BACKGROUND: Cerebral microembolization and atrophy complicate atrial fibrillation (AF). OBJECTIVES: We aimed to compare changes in neuroimaging findings between AF patients treated with catheter ablation and those treated with medical therapy. METHODS: In ... Full text Link to item Cite

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal article Circulation · January 2, 2024 AIM: The "2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation" provides recommendations to guide clinicians in the treatment of patients with atrial fibrillation. METHODS: A comprehensive literature search was conducted ... Full text Link to item Cite

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal article J Am Coll Cardiol · January 2, 2024 AIM: The "2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Patients With Atrial Fibrillation" provides recommendations to guide clinicians in the treatment of patients with atrial fibrillation. METHODS: A comprehensive literature search ... Full text Link to item Cite

Natural history of echocardiographic changes in atrial fibrillation: A case-controlled study of longitudinal remodeling.

Journal article Heart Rhythm · January 2024 BACKGROUND: Atrial fibrillation (AF) can be a cause and consequence of cardiac remodeling. The natural history of remodeling associated with AF is incompletely described. OBJECTIVE: The purpose of this study was to describe the frequency and timing of AF-a ... Full text Link to item Cite

Outcomes of patients implanted with an atrioventricular synchronous leadless ventricular pacemaker in the Medicare population.

Journal article Heart Rhythm · January 2024 BACKGROUND: The Micra AV Coverage with Evidence Development study is a novel analysis of utilization and outcomes associated with Micra AV leadless pacing in US Medicare patients. OBJECTIVE: The purpose of this study was to describe patient characteristics ... Full text Link to item Cite

Leadless pacemaker tine damage and fracture: novel complications of a novel device fixation mechanism.

Journal article Heart Rhythm O2 · January 2024 BACKGROUND: Leadless pacemakers represent a paradigm-changing advancement. However, they required innovative and novel device design, including the use of nitinol tines for fixation. OBJECTIVE: We aimed to understand the potential for fracture in the novel ... Full text Link to item Cite

Detection of brain lesions after catheter ablation depends on imaging criteria: insights from AXAFA-AFNET 5 trial.

Journal article Europace · December 6, 2023 AIMS: Left atrial catheter ablation is well established in patients with symptomatic atrial fibrillation (AF) but associated with risk of embolism to the brain. The present analysis aims to assess the impact of diffusion-weighted imaging (DWI) slice thickn ... Full text Link to item Cite

Intracardiac vs Transesophageal Echocardiography for Left Atrial Appendage Occlusion With Watchman FLX in the U.S.

Journal article JACC Clin Electrophysiol · December 2023 BACKGROUND: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac echocardiography ... Full text Link to item Cite

Atrial Fibrillation In Patients With Stroke Attributed to Large- or Small-Vessel Disease: 3-Year Results From the STROKE AF Randomized Clinical Trial.

Journal article JAMA Neurol · December 1, 2023 IMPORTANCE: The STROKE AF study found that in patients with prior ischemic stroke attributed to large-artery atherosclerotic disease (LAD) or small-vessel occlusive disease (SVD), 12% developed AF over 1 year when monitored with an insertable cardiac monit ... Full text Link to item Cite

Lead Extraction and Mortality Among Patients With Cardiac Implanted Electronic Device Infection.

Journal article JAMA Cardiol · December 1, 2023 IMPORTANCE: Complete hardware removal is a class I recommendation for cardiovascular implantable electronic device (CIED) infection, but practice patterns and outcomes remain unknown. OBJECTIVE: To quantify the number of Medicare patients with CIED infecti ... Full text Link to item Cite

Using machine learning to enhance prediction of atrial fibrillation recurrence after catheter ablation.

Journal article J Arrhythm · December 2023 BACKGROUND: Traditional risk scores for recurrent atrial fibrillation (AF) following catheter ablation utilize readily available clinical and echocardiographic variables and yet have limited discriminatory capacity. Use of data from cardiac imaging and dee ... Full text Link to item Cite

Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients With Atrial Fibrillation in the United States.

Journal article Circ Cardiovasc Qual Outcomes · December 2023 BACKGROUND: Among patients hospitalized for atrial fibrillation, the frequency of off-label direct oral anticoagulant (DOAC) dosing, associated factors, hospital-level variation, and temporal trends in contemporary practice are unknown. METHODS: Using the ... Full text Link to item Cite

Multicenter, Phase 2, Randomized Controlled Study of the Efficacy and Safety of Etripamil Nasal Spray for the Acute Reduction of Rapid Ventricular Rate in Patients With Symptomatic Atrial Fibrillation (ReVeRA-201).

Journal article Circ Arrhythm Electrophysiol · December 2023 BACKGROUND: Despite chronic therapies, atrial fibrillation (AF) leads to rapid ventricular rates (RVR) often requiring intravenous treatments. Etripamil is a fast-acting, calcium-channel blocker administered intranasally affecting the atrioventricular node ... Full text Link to item Cite

DAPT Is Comparable to OAC Following LAAC With WATCHMAN FLX: A National Registry Analysis.

Journal article JACC Cardiovasc Interv · November 27, 2023 BACKGROUND: Left atrial appendage occlusion (LAAO) is an approved alternative for stroke prevention in atrial fibrillation for patients with an "appropriate rationale" to avoid long-term oral anticoagulation (OAC). Many patients undergoing LAAO are at high ... Full text Link to item Cite

Expert Consensus on Comprehensive Early Rhythm Control in Addition to Guideline-Based Care for Atrial Fibrillation: A Modified Delphi Survey.

Journal article Am J Cardiol · November 15, 2023 Atrial fibrillation (AF) practice guidelines recommend a rhythm-control strategy to improve symptoms and quality of life, noting the side effects of antiarrhythmic drugs and catheter ablation. Emerging evidence indicates that comprehensive early rhythm con ... Full text Link to item Cite

Predictors of intracranial hemorrhage in patients with atrial fibrillation treated with oral anticoagulants: Insights from the GARFIELD-AF and ORBIT-AF registries.

Journal article Clin Cardiol · November 2023 BACKGROUND: An unmet need exists to reliably predict the risk of intracranial hemorrhage (ICH) in patients with atrial fibrillation (AF) treated with oral anticoagulants (OACs). HYPOTHESIS: An externally validated model improves ICH risk stratification. ME ... Full text Link to item Cite

Association of leadless pacing with ventricular and valvular function.

Journal article J Cardiovasc Electrophysiol · November 2023 BACKGROUND: Traditional transvenous pacemakers are associated with worsening tricuspid valve function due to lead-related leaflet impingement, as well as ventricular dysfunction related to electromechanical dyssynchrony from chronic right ventricular (RV) ... Full text Link to item Cite

Colchicine for the Prevention of Recurrent Arrhythmia After Catheter Ablation of Atrial Fibrillation: Results of a Single-Center, Retrospective Study.

Journal article Am J Cardiovasc Drugs · November 2023 BACKGROUND: There is evidence to suggest that colchicine reduces the risk of recurrent atrial fibrillation (AF) after catheter ablation; however, the tolerability and safety of colchicine in routine practice is unknown. METHODS: Patients undergoing cathete ... Full text Link to item Cite

Left ventricular lead implantation failure in an unselected nationwide cohort.

Journal article Heart Rhythm · October 2023 BACKGROUND: Left ventricular (LV) lead implantation is often the most challenging aspect of cardiac resynchronization therapy (CRT) procedures; early studies reported implant failure rates in ∼10% of cases. OBJECTIVE: The purpose of this study was to defin ... Full text Link to item Cite

Incidence and Predictors of Relapse After Weaning Immune Suppressive Therapy in Cardiac Sarcoidosis.

Journal article Am J Cardiol · October 1, 2023 Cardiac sarcoidosis (CS) is a relapsing-remitting disease, and immune suppression (IS) is the mainstay of therapy. Predictors of relapse for patients with CS in remission are not well characterized. We assessed incidence of relapse in consecutive patients ... Full text Link to item Cite

Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants.

Journal article Circulation · September 19, 2023 BACKGROUND: Current clinical decision tools for assessing bleeding risk in individuals with atrial fibrillation (AF) have limited performance and were developed for individuals treated with warfarin. This study develops and validates a clinical risk score ... Full text Link to item Cite

Ablation to Reduce Atrial Fibrillation Burden and Improve Outcomes: JACC Review Topic of the Week.

Journal article J Am Coll Cardiol · September 5, 2023 Atrial fibrillation is the most common atrial arrhythmia and accounts for a significant burden of cardiovascular disease globally. With advances in implanted and wearable cardiac monitoring technology, it is now possible to readily and accurately quantify ... Full text Link to item Cite

Preclinical cardiac perforation reduction in leadless pacing: An update to the Micra leadless pacemaker delivery system.

Journal article Pacing Clin Electrophysiol · September 2023 BACKGROUND: Leadless pacemakers have been developed to avoid some of the complications that are associated transvenous pacemakers. Pericardial effusion is a rare complication of leadless pacemaker implantation, which may result from perforation of the deli ... Full text Link to item Cite

Cardiac pacing and lead devices management: 25 years of research at EP Europace journal.

Journal article Europace · August 25, 2023 AIMS: Cardiac pacing represents a key element in the field of electrophysiology and the treatment of conduction diseases. Since the first issue published in 1999, EP Europace has significantly contributed to the development and dissemination of the researc ... Full text Link to item Cite

Insertable cardiac monitoring results in higher rates of atrial fibrillation diagnosis and oral anticoagulation prescription after ischaemic stroke.

Journal article Europace · August 2, 2023 AIMS: After an ischaemic stroke, atrial fibrillation (AF) detection allows for improved secondary prevention strategies. This study aimed to compare AF detection and oral anticoagulant (OAC) initiation in patients with an insertable cardiac monitor (ICM) v ... Full text Link to item Cite

Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial.

Journal article Lancet · July 8, 2023 BACKGROUND: Etripamil is a fast-acting, intranasally administered calcium-channel blocker in development for on-demand therapy outside a health-care setting for paroxysmal supraventricular tachycardia. We aimed to evaluate the efficacy and safety of etripami ... Full text Link to item Cite

Use of Ripple mapping to enhance localization and ablation of outflow tract premature ventricular contractions.

Journal article J Cardiovasc Electrophysiol · July 2023 INTRODUCTION: Accurate localization of septal outflow tract premature ventricular contractions (PVCs) is often difficult due to frequent mid-myocardial or protected origin. Compared with traditional activation mapping, CARTO Ripple mapping provides visuali ... Full text Link to item Cite

Optimal conditions for high-power, short-duration radiofrequency ablation using a novel, flexible-tipped, force-sensing catheter.

Journal article Heart Rhythm O2 · July 2023 BACKGROUND: High-power, short-duration (HPSD) radiofrequency ablation (RFA) reduces procedure time; however, safety and efficacy thresholds vary with catheter design. OBJECTIVE: The study sought to determine optimal HPSD ablation conditions with a novel fl ... Full text Link to item Cite

Real-world utilization of the pill-in-the-pocket method for terminating episodes of atrial fibrillation: data from the multinational Antiarrhythmic Interventions for Managing Atrial Fibrillation (AIM-AF) survey.

Journal article Europace · June 2, 2023 AIMS: Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. Episodes may stop spontaneously (paroxysmal AF); may terminate only via intervention (persistent AF); or may persist indefinitely (permanent AF) (see E ... Full text Link to item Cite

Early mortality after inpatient versus outpatient catheter ablation in patients with atrial fibrillation.

Journal article Heart Rhythm · June 2023 BACKGROUND: Rates of early mortality and complications after catheter ablation (CA) of atrial fibrillation (AF) vary across health care settings. OBJECTIVE: The purpose of this study was to identify the rate and predictors of early mortality (within 30 day ... Full text Link to item Cite

Efficacy and Safety of Adjunctive and Primary Use of the TightRail Mechanical Cutting Sheath for Lead Extraction.

Journal article Circ Arrhythm Electrophysiol · June 2023 BACKGROUND: Rotational cutting tools are increasingly used in transvenous lead extraction. There are limited data on their safety and efficacy, particularly when used adjunctively for stalled progression. The aim of this study was to evaluate the utilizati ... Full text Link to item Cite

Racial/ethnic and sex differences in safety outcomes and atrial fibrillation/atrial flutter-related acute healthcare utilization after catheter ablation of atrial fibrillation.

Journal article Heart Rhythm O2 · May 2023 BACKGROUND: Catheter ablation is recommended for the treatment of symptomatic atrial fibrillation (AF) refractory to medical therapy. OBJECTIVE: The study sought to examine racial/ethnic and sex differences in complications and AF/atrial flutter (AFL)-rela ... Full text Link to item Cite

Early Lead Extraction for Infected Implanted Cardiac Electronic Devices: JACC Review Topic of the Week.

Journal article J Am Coll Cardiol · April 4, 2023 Infection remains a serious complication associated with the cardiac implantable electronic devices (CIEDs), leading to substantial clinical and economic burden globally. This review assesses the burden of cardiac implantable electronic device infection (C ... Full text Link to item Cite

Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion.

Journal article Stroke · April 2023 BACKGROUND: Carotid stenosis is thought to be the primary risk factor for central retinal artery occlusion (CRAO); however, it is not known whether atrial fibrillation (AF)-a cardiac arrhythmia that underlies over 25% of cerebral ischemic strokes-predispos ... Full text Link to item Cite

Rates and predictors of hospital and emergency department care after catheter ablation of atrial fibrillation.

Journal article J Cardiovasc Electrophysiol · April 2023 INTRODUCTION: Although atrial fibrillation (AF) ablation has become increasingly safer, rehospitalization and emergency department (ED) evaluations can occur in the postablation period. Better understanding of the frequency, causes, and predictors for hosp ... Full text Link to item Cite

Leadless versus transvenous single-chamber ventricular pacemakers: 3 year follow-up of the Micra CED study.

Journal article J Cardiovasc Electrophysiol · April 2023 INTRODUCTION: The Micra Coverage with Evidence Development (CED) Study is a novel comparative analysis of Micra (leadless VVI) and transvenous single-chamber ventricular pacemakers (transvenous VVI) using administrative claims data. To compare chronic comp ... Full text Link to item Cite

Variability in Nonvitamin K Oral Anticoagulant Dose Eligibility and Adjustment According to Renal Formulae and Clinical Outcomes in Patients With Atrial Fibrillation With and Without Chronic Kidney Disease: Insights From ORBIT-AF II.

Journal article J Am Heart Assoc · March 21, 2023 Background Nonvitamin K oral anticoagulants require dose adjustment based on kidney function.The most common estimate of kidney function employed in clinical practice is estimated glomerular filtration rate (eGFR); however, product monographs recommend the ... Full text Link to item Cite

Postoperative atrial fibrillation: from mechanisms to treatment.

Journal article Eur Heart J · March 21, 2023 Postoperative atrial fibrillation (POAF) is the most common type of secondary atrial fibrillation (AF) and despite progress in prevention and treatment, remains an important clinical problem for patients undergoing a variety of surgical procedures, and in ... Full text Link to item Cite

Alert-driven vs scheduled remote monitoring of implantable cardiac defibrillators: A cost-consequence analysis from the TRUST trial.

Journal article Heart Rhythm · March 2023 BACKGROUND: Alert-driven remote patient monitoring (RPM) or fully virtual care without routine evaluations may reduce clinic workload and promote more efficient resource allocation, principally by diminishing nonactionable patient encounters. OBJECTIVE: Th ... Full text Link to item Cite

Continuous Monitoring of Heart Rate Variability and Clinical Outcomes in Patients with Implantable Cardioverter Defibrillators.

Journal article Curr Probl Cardiol · March 2023 While heart rate variability (HRV) is an established marker of cardiovascular health, the extent to which continuously measured HRV changes over time and the relationship between these changes and clinical outcomes are less clear. We performed a health sys ... Full text Link to item Cite

Contemporary trends in cardiac electrophysiology procedures in the United States, and impact of a global pandemic.

Journal article Heart Rhythm O2 · March 2023 BACKGROUND: There are limited data on trends in nationwide cardiac electrophysiology (EP) procedures in the United States before and during the global COVID-19 pandemic. OBJECTIVE: We aimed to understand contemporary EP procedural trends and how the COVID- ... Full text Link to item Cite

Clinical Evaluation of Factor XIa Inhibitor Drugs: JACC Review Topic of the Week.

Journal article J Am Coll Cardiol · February 28, 2023 Factor XI/XIa (FXI/FXIa) represents a potential target for improved precision in anticoagulation because it is involved primarily in thrombus formation and plays a much smaller role in clotting and hemostasis. This suggests that the inhibition of FXI/XIa c ... Full text Link to item Cite

Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision-Making Pathway.

Journal article J Am Heart Assoc · February 7, 2023 Background Oral anticoagulation reduces stroke and disability in atrial fibrillation (AF) but is underused. We evaluated the effects of a novel patient-clinician shared decision-making (SDM) tool in reducing oral anticoagulation patient's decisional confli ... Full text Link to item Cite

Neuromodulation therapy for atrial fibrillation.

Journal article Heart Rhythm · January 2023 Atrial fibrillation has a multifactorial pathophysiology influenced by cardiac autonomic innervation. Both sympathetic and parasympathetic influences are profibrillatory. Innovative therapies targeting the neurocardiac axis include catheter ablation or pha ... Full text Link to item Cite

Correlation between AV synchrony and device collected AM-VP sequence counter in atrioventricular synchronous leadless pacemakers: A real-world assessment.

Journal article J Cardiovasc Electrophysiol · January 2023 INTRODUCTION: Micra atrioventricular (AV) provides leadless atrioventricular synchronous pacing by sensing atrial contraction (A4 signal). Real-world operation and reliability of AV synchrony (AVS) assessment using device data have not been described. The ... Full text Open Access Link to item Cite

Intersection of atrial fibrillation and heart failure with mildly reduced and preserved ejection fraction in >400 000 participants in the Get With The Guidelines-Heart Failure Registry.

Journal article Eur J Heart Fail · January 2023 AIMS: Although atrial fibrillation (AF) frequently coexists with heart failure with preserved ejection fraction (HFpEF), few data are available evaluating AF-specific care patterns and post-discharge outcomes in patients hospitalized for HFpEF. We evaluate ... Full text Link to item Cite

Predictors of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: A Prespecified Secondary Analysis of the STROKE AF Randomized Clinical Trial.

Journal article JAMA Neurol · January 1, 2023 IMPORTANCE: The Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE AF) trial found that approximately 1 in 8 patients with recent ischemic stroke attributed to large- or small-vessel disease had poststroke atrial fibrillation (AF) detected by ... Full text Link to item Cite

Electrocardiographic parameters associated with pacemaker induced cardiomyopathy.

Journal article J Electrocardiol · 2023 BACKGROUND: Chronic right ventricular (RV) pacing can induce left ventricular (LV) dyssynchrony and cause pacemaker induced cardiomyopathy (PiCM). Identifying which patients are at risk for PiCM is limited. METHODS: Patients receiving RV-only permanent pac ... Full text Link to item Cite

Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter.

Journal article Heart Rhythm O2 · January 2023 BACKGROUND: High-power, short-duration (HPSD) radiofrequency ablation (RFA) may reduce ablation time. Concerns that catheter-mounted thermocouples (TCs) can underestimate tissue temperature, resulting in elevated risk of steam pop formation, potentially li ... Full text Link to item Cite

Race and Ethnic and Sex Differences in Rhythm Control Treatment of Incident Atrial Fibrillation.

Journal article Clinicoecon Outcomes Res · 2023 BACKGROUND: Atrial fibrillation (AF) is associated with considerable morbidity and mortality. Timely management and treatment is critical in alleviating AF disease burden. Variation in treatment by race and ethnic and sex could lead to inequities in health ... Full text Link to item Cite

Healthcare resource utilization and costs for patients with postoperative atrial fibrillation in the United States.

Journal article J Med Econ · 2023 BACKGROUND: Postoperative atrial fibrillation (POAF) is one of the most common complications following cardiac surgery. POAF is associated with increased hospitalization costs, but its long-term economic burden is not well defined. OBJECTIVE: To assess 30- ... Full text Link to item Cite

Atrial fibrillation as a novel risk factor for retinal stroke: A protocol for a population-based retrospective cohort study.

Journal article PLoS One · 2023 Central retinal artery occlusion (CRAO; retinal stroke or eye stroke) is an under-recognized, disabling form of acute ischemic stroke which causes severe visual loss in one eye. The classical risk factor for CRAO is ipsilateral carotid stenosis; however, n ... Full text Link to item Cite

Safety and feasibility of same-day discharge for catheter ablation of atrial fibrillation: a systematic review and meta-analysis.

Journal article J Interv Card Electrophysiol · December 2022 PURPOSE: Most centers performing catheter ablation (CA) of atrial fibrillation (AF) admit the patients for an overnight hospital stay to monitor for post-procedure complications, but the clinical benefits of this overnight hospital admission policy have no ... Full text Link to item Cite

Safety of continuous left atrial phased-array intracardiac echocardiography during left atrial ablation for atrial fibrillation.

Journal article Heart Rhythm O2 · December 2022 BACKGROUND: Pulmonary vein (PV) isolation using radiofrequency ablation (RFA) to treat atrial fibrillation (AF) requires delivery of contiguous transmural lesions at the PV antra while avoiding injury to the esophagus. Continuous 2-dimensional phased-array ... Full text Link to item Cite

Association of Race and Ethnicity With Oral Anticoagulation and Associated Outcomes in Patients With Atrial Fibrillation: Findings From the Get With The Guidelines-Atrial Fibrillation Registry.

Journal article JAMA Cardiol · December 1, 2022 IMPORTANCE: Oral anticoagulation (OAC) is underprescribed in underrepresented racial and ethnic group individuals with atrial fibrillation (AF). Little is known of how differential OAC prescribing relates to inequities in AF outcomes. OBJECTIVE: To compare ... Full text Link to item Cite

Advances in Cardiac Electrophysiology.

Journal article Circ Arrhythm Electrophysiol · December 2022 Despite the global COVID-19 pandemic, during the past 2 years, there have been numerous advances in our understanding of arrhythmia mechanisms and diagnosis and in new therapies. We increased our understanding of risk factors and mechanisms of atrial arrhy ... Full text Link to item Cite

Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation.

Journal article Heart Rhythm O2 · December 2022 BACKGROUND: Oral anticoagulation (OAC) reduces the risk of thromboembolic events in patients with atrial fibrillation (AF); however, thromboembolism (TE) still can occur despite OAC. Factors associated with residual risk for stroke, systemic embolism, or t ... Full text Link to item Cite

Omnipolar Versus Bipolar Electrode Mapping in Patients With Atrial Fibrillation Undergoing Catheter Ablation.

Journal article JACC Clin Electrophysiol · December 2022 BACKGROUND: Peak-to-peak bipolar voltage varies with electrode orientation, fractionation, and collision events. Novel, omnipolar mapping is less dependent on electrode orientation but has limited data in humans. OBJECTIVES: This study sought to compare bi ... Full text Link to item Cite

Prospective Evaluation of the Correlation Between Gated Cardiac Computed Tomography Detected Vascular Fibrosis and Ease of Transvenous Lead Extraction.

Journal article Circ Arrhythm Electrophysiol · November 2022 BACKGROUND: Difficulty of lead extraction does not track well with procedural complications, but several small retrospective studies have lead fibrosis on computed tomography as an important indicator of difficult lead extraction. The purpose of the presen ... Full text Link to item Cite

Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics.

Journal article Circ Genom Precis Med · October 2022 BACKGROUND: Inherited primary arrhythmia syndromes and arrhythmogenic cardiomyopathies can lead to sudden cardiac arrest in otherwise healthy individuals. The burden and expression of these diseases in a real-world, well-phenotyped cardiovascular populatio ... Full text Link to item Cite

Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation : A Decision Analysis.

Journal article Ann Intern Med · September 2022 BACKGROUND: Left atrial appendage occlusion (LAAO) is a potential alternative to oral anticoagulants in selected patients with atrial fibrillation (AF). Compared with anticoagulants, LAAO decreases major bleeding risk, but there is uncertainty regarding th ... Full text Open Access Link to item Cite

Cost-Effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal article Circulation · August 16, 2022 BACKGROUND: In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce the primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with d ... Full text Link to item Cite

Atrial branch coronary artery stenosis as a mechanism for atrial fibrillation.

Journal article Heart Rhythm · August 2022 BACKGROUND: The etiology of atrial fibrillation (AF) is multifactorial and incompletely understood. OBJECTIVE: The purpose of this study was to evaluate the association between coronary artery disease (CAD) affecting atrial tissue and AF. METHODS: Patients ... Full text Link to item Cite

Development and validation of a risk score for predicting pericardial effusion in patients undergoing leadless pacemaker implantation: experience with the Micra transcatheter pacemaker.

Journal article Europace · July 21, 2022 AIMS: There is limited information on what clinical factors are associated with the development of pericardial effusion after leadless pacemaker implantation. We sought to determine predictors of and to develop a risk score for pericardial effusion in pati ... Full text Link to item Cite

Patterns of care for first-detected atrial fibrillation: Insights from the Get With The Guidelines® - Atrial Fibrillation registry.

Journal article Heart Rhythm · July 2022 BACKGROUND: Despite multiple trials comparing rate with rhythm control, there is no consensus on the optimal management of first-detected atrial fibrillation (AF). OBJECTIVE: We analyzed current patterns of care for first-detected AF in the nationwide Get ... Full text Link to item Cite

Dronedarone for the treatment of atrial fibrillation with concomitant heart failure with preserved and mildly reduced ejection fraction: a post-hoc analysis of the ATHENA trial.

Journal article Eur J Heart Fail · June 2022 AIMS: Limited therapeutic options are available for the management of atrial fibrillation/flutter (AF/AFL) with concomitant heart failure (HF) with preserved (HFpEF) and mildly reduced ejection fraction (HFmrEF). Dronedarone reduces the risk of cardiovascu ... Full text Link to item Cite

Heart Rhythm Society Atrial Fibrillation Centers of Excellence Study: A survey analysis of stakeholder practices, needs, and barriers.

Journal article Heart Rhythm · June 2022 BACKGROUND: An integrated, coordinated, and patient-centered approach to atrial fibrillation (AF) care delivery may improve outcomes and reduce cost. OBJECTIVE: The purpose of this study was to gain a better understanding from key stakeholder groups on cur ... Full text Link to item Cite

Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study.

Journal article Lancet · April 9, 2022 BACKGROUND: Direct-acting oral anticoagulant use for stroke prevention in atrial fibrillation is limited by bleeding concerns. Asundexian, a novel, oral small molecule activated coagulation factor XIa (FXIa) inhibitor, might reduce thrombosis with minimal ... Full text Link to item Cite

MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial.

Journal article Circulation · March 22, 2022 BACKGROUND: We aimed to assess the prevalence of ischemic brain lesions detected by magnetic resonance imaging and their association with cognitive function 3 months after first-time ablation using continuous oral anticoagulation in patients with paroxysma ... Full text Link to item Cite

Leadless vs. transvenous single-chamber ventricular pacing in the Micra CED study: 2-year follow-up.

Journal article Eur Heart J · March 21, 2022 AIMS: Clinical trials have demonstrated the safety and efficacy of the Micra leadless VVI pacemaker; however, longer-term outcomes in a large, real-world population with a contemporaneous comparison to transvenous VVI pacemakers have not been examined. We ... Full text Link to item Cite

AIM-AF: A Physician Survey in the United States and Europe.

Journal article J Am Heart Assoc · March 15, 2022 Background Guideline recommendations are the accepted reference for selection of therapies for rhythm control of atrial fibrillation (AF). This study was designed to understand physicians' treatment practices and adherence to guidelines. Methods and Result ... Full text Link to item Cite

GARFIELD-AF risk score for mortality, stroke, and bleeding within 2 years in patients with atrial fibrillation.

Journal article Eur Heart J Qual Care Clin Outcomes · March 2, 2022 AIMS: To determine whether the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) integrated risk tool predicts mortality, non-haemorrhagic stroke/systemic embolism, and major bleeding for up to 2 years after new-onset AF and to a ... Full text Link to item Cite

Design and Rationale of a Phase 2 Study of NeurOtoxin (Botulinum Toxin Type A) for the PreVention of Post-Operative Atrial Fibrillation - The NOVA Study.

Journal article Am Heart J · March 2022 BACKGROUND: Post-operative AF (POAF) is the most common complication following cardiac surgery, occurring in 30% to 60% of patients undergoing bypass and/or valve surgery. POAF is associated with longer intensive care unit/hospital stays, increased healthc ... Full text Link to item Cite

Achievement and quality measure attainment in patients hospitalized with atrial fibrillation: Results from The Get With The Guidelines - Atrial Fibrillation (GWTG-AFIB) registry.

Journal article Am Heart J · March 2022 BACKGROUND: The Get With The Guidelines - Atrial Fibrillation (GWTG-AFIB) Registry uses achievement and quality measures to improve the care of patients with atrial fibrillation (AF). We sought to evaluate overall and site-level variation in attainment of ... Full text Link to item Cite

Leadless pacemaker implantation after lead extraction for cardiac implanted electronic device infection.

Journal article J Cardiovasc Electrophysiol · March 2022 BACKGROUND: Cardiac implanted electronic device (CIED) pocket and systemic infection remain common complications with traditional CIEDs and are associated with high morbidity and mortality. Leadless pacemakers may be an attractive pacing alternative for ma ... Full text Link to item Cite

Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE).

Journal article J Acquir Immune Defic Syndr · March 1, 2022 BACKGROUND: People with HIV (PWH) are at increased risk of cardiovasvular disease (CVD) and sudden cardiac death. Previous work has suggested an association between HIV infection and electrocardiographic (ECG) abnormalities. There are limited data on the b ... Full text Link to item Cite

Seasonal Variation of Atrial Fibrillation Admission and Quality of Care in the United States.

Journal article J Am Heart Assoc · February 15, 2022 Background Currently, little is known regarding seasonal variation for atrial fibrillation (AF) in the United States and whether quality of care for AF varies between seasons. Methods and Results The GWTG-AFib (Get With The Guidelines-AFib) registry was in ... Full text Link to item Cite

Leadless pacemaker implant, anticoagulation status, and outcomes: Results from the Micra Transcatheter Pacing System Post-Approval Registry.

Journal article Heart Rhythm · February 2022 BACKGROUND: Early results from the Micra investigational trial and Micra Post-Approval Registry (PAR) demonstrated excellent safety and device performance; however, outcomes based on anticoagulation (AC) status at implant have not been evaluated. OBJECTIVE ... Full text Link to item Cite

Association between economic and arrhythmic burden of paroxysmal atrial fibrillation in patients with cardiac implanted electronic devices.

Journal article Am Heart J · February 2022 BACKGROUND: As the prevalence of atrial fibrillation (AF) increases, a greater understanding of the costs associated with AF care is required. While individuals with greater arrhythmic burden may interact with the health system more frequently, the relatio ... Full text Link to item Cite

Bimodal distribution of atrial fibrillation burden in 3 distinct cohorts: What is 'paroxysmal' atrial fibrillation?

Journal article Am Heart J · February 2022 BACKGROUND: Burden of atrial fibrillation (AF), as a continuous measure, is an emerging alternative classification often assumed to increase linearly with progression of disease. Yet there are no descriptions of AF burden distributions across populations. ... Full text Link to item Cite

Hyperglycemia, Risk of Subsequent Stroke, and Efficacy of Dual Antiplatelet Therapy: A Post Hoc Analysis of the POINT Trial.

Journal article J Am Heart Assoc · February 2022 Background One-quarter of all strokes are subsequent events. It is not known whether higher levels of blood glucose are associated with an increased risk of subsequent stroke after high-risk transient ischemic attack or minor ischemic stroke. Methods and R ... Full text Link to item Cite

Comparative Safety and Effectiveness of Sotalol Versus Dronedarone After Catheter Ablation for Atrial Fibrillation.

Journal article J Am Heart Assoc · February 2022 Background Atrial tachyarrhythmias are common after atrial fibrillation ablation, so adjunctive antiarrhythmic drug therapy is often used. Data on the effectiveness and safety of dronedarone and sotalol after AF ablation are limited. Here, we compared heal ... Full text Link to item Cite

Arrhythmic Burden and the Risk of Cardiovascular Outcomes in Patients With Paroxysmal Atrial Fibrillation and Cardiac Implanted Electronic Devices.

Journal article Circ Arrhythm Electrophysiol · February 2022 BACKGROUND: Whether the amount of atrial fibrillation (AF) patients experience conveys important prognostic information beyond that provided by the diagnosis of AF is uncertain. The study objective was to assess the dose-response relationship between devic ... Full text Link to item Cite

Cases of Azygous Coil Extraction.

Journal article Heart Rhythm O2 · February 2022 BACKGROUND: Procedural and clinical outcomes of patients undergoing extraction or removal of azygous coils are not well characterized. OBJECTIVE: Evaluate outcomes in patients who undergo device extraction with an azygous coil in situ. METHODS: Patients un ... Full text Link to item Cite

Temporal trends and predictors of surgical ablation for atrial fibrillation across a multistate healthcare system.

Journal article Heart Rhythm O2 · February 2022 BACKGROUND: Multiple class I and class IIa recommendations exist related to surgical ablation (SA) of atrial fibrillation (AF) in patients undergoing cardiac surgery. OBJECTIVE: Examine temporal trends and predictors of SA for AF in a large US healthcare s ... Full text Link to item Cite

Diagnosis-to-ablation time predicts recurrent atrial fibrillation and rehospitalization following catheter ablation.

Journal article Heart Rhythm O2 · February 2022 BACKGROUND: Wait times for catheter ablation in patients with symptomatic atrial fibrillation (AF) may influence clinical outcomes. OBJECTIVE: This study examined the relationship between the duration from AF diagnosis to ablation, or diagnosis-to-ablation ... Full text Open Access Link to item Cite

Dose-limiting, adverse event-associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial.

Journal article Heart Rhythm O2 · February 2022 BACKGROUND: Heart failure (HF) patients with atrial fibrillation (AF) often have conduction system disorders, which may be worsened by β-blocker therapy. OBJECTIVE: In a post hoc analysis we examined the prevalence of bradycardia and its association with a ... Full text Link to item Cite

Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex.

Journal article Circulation · January 25, 2022 BACKGROUND: Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages over study-level data. METHODS: We used individual patient dat ... Full text Link to item Cite

Do baseline characteristics and treatments account for geographical disparities in the outcomes of patients with newly diagnosed atrial fibrillation? The prospective GARFIELD-AF registry.

Journal article BMJ Open · January 7, 2022 OBJECTIVE: In patients with newly diagnosed atrial fibrillation (AF), do baseline risk factors and stroke prevention strategies account for the geographically diverse outcomes. DESIGN: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation is a pro ... Full text Link to item Cite

Quantifying the Impact of Atrial Fibrillation on Heart Failure-Related Patient-Reported Outcomes in the Utah mEVAL Program.

Journal article J Card Fail · January 2022 BACKGROUND: Atrial fibrillation (AF) frequently complicates heart failure (HF), and each is associated with lower overall health-related quality of life. We aimed to quantify the incremental burden of AF on the health-related quality of life of patients wi ... Full text Link to item Cite

The importance of the design of observational studies in comparative effectiveness research: Lessons from the GARFIELD-AF and ORBIT-AF registries.

Journal article Am Heart J · January 2022 Randomized controlled trials (RCTs) are considered the gold standard for estimating the effectiveness of a treatment. However, in many instances they are impractical to conduct because of time limitations, cost restrictions, or ethical reasons. As a conseq ... Full text Link to item Cite

Heart Watch Study: protocol for a pragmatic randomised controlled trial.

Journal article BMJ Open · December 30, 2021 INTRODUCTION: Personal digital devices that provide health information, such as the Apple Watch, have developed an increasing array of cardiopulmonary tracking features which have received regulatory clearance and are directly marketed to consumers. Despit ... Full text Link to item Cite

Patient characteristics, care patterns, and outcomes of atrial fibrillation associated hospitalizations in patients with chronic kidney disease and end-stage renal disease.

Journal article Am Heart J · December 2021 BACKGROUND: Chronic Kidney Disease (CKD) and end-stage renal disease (ESRD) are associated with poor outcomes in patients with cardiovascular disease. There is a paucity of contemporary data on in-hospital outcomes and care patterns of atrial fibrillation ... Full text Link to item Cite

Atrial Fibrillation and Coronary Artery Disease: A Long-Term Perspective on the Need for Combined Antithrombotic Therapy.

Journal article Circ Cardiovasc Interv · December 2021 BACKGROUND: Older adults with atrial fibrillation (AF) are often treated with the shortest possible duration of antiplatelet/anticoagulant therapy after myocardial infarction (MI) or percutaneous coronary intervention (PCI) due to concern for bleeding. How ... Full text Link to item Cite

Continuous and discontinuous radiofrequency energy delivery on the atrial free wall: Lesion transmurality, width, and biophysical characteristics.

Journal article Heart Rhythm O2 · December 2021 BACKGROUND: Although lesion transmurality is required for durable pulmonary vein isolation, excess ablation is associated with increased risk of complications. OBJECTIVE: We sought to understand the impact of interrupted radiofrequency (RF) delivery condit ... Full text Link to item Cite

Erratum to: 2021 ISHNE / HRS / EHRA / APHRS Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology / Heart Rhythm Society / European Heart Rhythm Association / Asia Pacific Heart Rhythm Society (European Heart Journal - Digital Health DOI: 10.1093/ehjdh/ztab001)

Journal article European Heart Journal Digital Health · December 1, 2021 In the originally published version of this manuscript, disclosure of several authors' handling editor statuses was omitted from the supplementary material in error. This error has been corrected online. ... Full text Cite

Sex Differences in Ablation Strategy, Lesion Sets, and Complications of Catheter Ablation for Atrial Fibrillation: An Analysis From the GWTG-AFIB Registry.

Journal article Circ Arrhythm Electrophysiol · November 2021 BACKGROUND: When presenting for atrial fibrillation (AF) ablation, women, compared with men, tend to have more nonpulmonary vein triggers and advanced atrial disease. Whether this informs differences in AF ablation strategy is not well described. We aimed ... Full text Link to item Cite

Termination Based on Event Accrual in Per Protocol Versus Intention to Treat in the ROCKET AF Trial.

Journal article J Am Heart Assoc · October 5, 2021 Background In event-driven clinical trials, study termination is based on accrual of a target number of primary efficacy events. For noninferiority trials in which superiority is conditionally examined, the ideal cohort in which to track event accrual is u ... Full text Link to item Cite

Contemporaneous Comparison of Outcomes Among Patients Implanted With a Leadless vs Transvenous Single-Chamber Ventricular Pacemaker.

Journal article JAMA Cardiol · October 1, 2021 IMPORTANCE: The safety and efficacy of leadless VVI pacemakers have been demonstrated in multiple clinical trials, but the comparative performance of the device in a large, real-world population has not been examined. OBJECTIVE: To compare patient characte ... Full text Link to item Cite

Optimizing mechanically sensed atrial tracking in patients with atrioventricular-synchronous leadless pacemakers: A single-center experience.

Journal article Heart Rhythm O2 · October 2021 BACKGROUND: Atrioventricular (AV)-synchronous single-chamber leadless pacing using a mechanical atrial sensing algorithm produced high AV synchrony in clinical trials, but clinical practice experience with these devices has not yet been described. OBJECTIV ... Full text Open Access Link to item Cite

Dosing of Direct Oral Anticoagulants in Patients with Moderate Chronic Kidney Disease in US Clinical Practice: Results from the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF II).

Journal article Am J Cardiovasc Drugs · September 2021 INTRODUCTION: Direct oral anticoagulants (DOACs) have partial renal clearance and generally require dosage adjustments based on renal function. While current US and European guidance recommends dose adjustments in patients with moderate chronic kidney dise ... Full text Link to item Cite

The role of posterior wall isolation in catheter ablation of persistent atrial fibrillation.

Journal article J Cardiovasc Electrophysiol · September 2021 The left atrial posterior wall has many embryologic, anatomic, and electrophysiologic characteristics, that are important for the initiation and maintenance of persistent atrial fibrillation. The left atrial posterior wall is a potential target for ablatio ... Full text Link to item Cite

Long-term oral anticoagulant after catheter ablation for atrial fibrillation.

Journal article Europace · August 6, 2021 Catheter ablation is superior to antiarrhythmic therapy for the reduction of symptomatic atrial fibrillation (AF), recurrence, and burden. The possibility of a true 'rhythm' control strategy with catheter ablation has re-opened the debate on rate vs. rhyth ... Full text Link to item Cite

Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival.

Journal article Heart Rhythm · August 2021 BACKGROUND: Ventricular arrhythmias (VAs) and electrical storm (ES) are recognized complications following left ventricular assist device (LVAD) implantation; however, their association with long term-outcomes remains poorly understood. OBJECTIVE: The purp ... Full text Link to item Cite

Efficacy of a centralized, blended electronic, and human intervention to improve direct oral anticoagulant adherence: Smartphones to improve rivaroxaban ADHEREnce in atrial fibrillation (SmartADHERE) a randomized clinical trial.

Journal article Am Heart J · July 2021 BACKGROUND: Improving adherence to direct oral anticoagulants (DOAC) is challenging, and simple text messaging reminders have not been effective. METHODS: SmartADHERE was a randomized trial that tested a personalized digital and human direct oral anticoagu ... Full text Link to item Cite

Behavior of AV synchrony pacing mode in a leadless pacemaker during variable AV conduction and arrhythmias.

Journal article J Cardiovasc Electrophysiol · July 2021 INTRODUCTION: MARVEL 2 assessed the efficacy of mechanical atrial sensing by a ventricular leadless pacemaker, enabling a VDD pacing mode. The behavior of the enhanced MARVEL 2 algorithm during variable atrio-ventricular conduction (AVC) and/or arrhythmias ... Full text Link to item Cite

Rivaroxaban versus warfarin in patients with atrial fibrillation enrolled in Latin America: Insights from ROCKET AF.

Journal article Am Heart J · June 2021 BACKGROUND: ROCKET AF demonstrated the efficacy and safety of rivaroxaban compared with warfarin for the prevention of stroke and systemic embolism (SE) in patients with atrial fibrillation (AF). We examined baseline characteristics and outcomes in patient ... Full text Link to item Cite

Effect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial.

Journal article JAMA · June 1, 2021 IMPORTANCE: Patients with ischemic stroke attributed to large- or small-vessel disease are not considered at high risk for atrial fibrillation (AF), and the AF incidence rate in this population is unknown. OBJECTIVES: To determine whether long-term cardiac ... Full text Link to item Cite

Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF.

Journal article Heart Rhythm O2 · June 2021 BACKGROUND: Insulin use may be a better predictor of stroke risk and morbidity and mortality than diabetes in patients with atrial fibrillation (AF). OBJECTIVES: Determine if the increased risk of stroke observed in patients with AF and diabetes is restric ... Full text Link to item Cite

The reward of understanding risk in atrial fibrillation.

Journal article Eur J Prev Cardiol · May 22, 2021 Full text Link to item Cite

Atrial fibrillation burden and heart failure: Data from 39,710 individuals with cardiac implanted electronic devices.

Journal article Heart Rhythm · May 2021 BACKGROUND: Atrial fibrillation (AF) and heart failure (HF) often accompany one another, and each is independently associated with poor outcomes. However, the association between AF burden and outcomes is poorly understood. OBJECTIVE: The purpose of this s ... Full text Link to item Cite

Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial.

Journal article Circulation · April 6, 2021 BACKGROUND: In patients with heart failure and atrial fibrillation (AF), several clinical trials have reported improved outcomes, including freedom from AF recurrence, quality of life, and survival, with catheter ablation. This article describes the treatm ... Full text Open Access Link to item Cite

Patterns of oral anticoagulation use with cardioversion in clinical practice.

Journal article Heart · April 2021 BACKGROUND: Cardioversion is common among patients with atrial fibrillation (AF). We hypothesised that novel oral anticoagulants (NOAC) used in clinical practice resulted in similar rates of stroke compared with vitamin K antagonists (VKA) for cardioversio ... Full text Link to item Cite

A Predictive Model for the Long-Term Electrical Performance of a Leadless Transcatheter Pacemaker.

Journal article JACC Clin Electrophysiol · April 2021 OBJECTIVES: This study sought to formulate a predictive model for describing the long-term electrical performance of Micra (Medtronic, Mounds View, Minnesota). BACKGROUND: The Micra leadless pacemaker is an alternative ventricular pacing option that avoids ... Full text Link to item Cite

Variation in Antithrombotic Therapy and Clinical Outcomes in Patients With Preexisting Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Circ Cardiovasc Interv · April 2021 BACKGROUND: Optimal antithrombotic management of patients with preexisting atrial fibrillation undergoing transcatheter aortic valve replacement is challenging given the need to balance the risk of bleeding and thromboembolism. We aimed to examine variatio ... Full text Link to item Cite

2021 ISHNE/HRS/EHRA/APHRS collaborative statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society

Journal article Journal of Arrhythmia · April 1, 2021 This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society describes the current status of mobile health (“mHealth”) tech ... Full text Cite

Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale: From the COMBINE AF (A Collaboration between Multiple institutions to Better Investigate Non-vitamin K antagonist oral anticoagulant use in Atrial Fibrillation) Investigators.

Journal article Am Heart J · March 2021 BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are the preferred class of medications for prevention of stroke and systemic embolism in patients with atrial fibrillation unless contraindications exist. Five large, international, randomize ... Full text Link to item Cite

Leadless pacemaker implant with concomitant atrioventricular node ablation: Experience with the Micra transcatheter pacemaker.

Journal article J Cardiovasc Electrophysiol · March 2021 BACKGROUND: The feasibility and outcomes of concomitant atrioventricular node ablation (AVNA) and leadless pacemaker implant are not well studied. We report outcomes in patients undergoing Micra implant with concomitant AVNA. METHODS: Patients undergoing A ... Full text Link to item Cite

2021 ISHNE/ HRS/ EHRA/ APHRS collaborative statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society.

Journal article Ann Noninvasive Electrocardiol · March 2021 This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/ Heart Rhythm Society/ European Heart Rhythm Association/ Asia Pacific Heart Rhythm Society describes the current status of mobile health ("mHealth") t ... Full text Link to item Cite

2021 ISHNE / HRS / EHRA / APHRS Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals

Journal article European Heart Journal Digital Health · March 1, 2021 This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology / Heart Rhythm Society / European Heart Rhythm Association / Asia Pacific Heart Rhythm Society describes the current status of mobile health ("mHealth" ... Full text Cite

Procedure characteristics and outcomes of atrial fibrillation ablation procedures using cryoballoon versus radiofrequency ablation: A report from the GWTG-AFIB registry.

Journal article J Cardiovasc Electrophysiol · February 2021 INTRODUCTION: Cryoballoon ablation (CBA) is an alternative to radiofrequency ablation (RFA) for ablation of atrial fibrillation (AF) and real-world comparisons of this strategy are lacking. As such, we sought to compare patient and periprocedural character ... Full text Link to item Cite

Guideline-Concordant Antiarrhythmic Drug Use in the Get With The Guidelines-Atrial Fibrillation Registry.

Journal article Circ Arrhythm Electrophysiol · February 2021 BACKGROUND: Antiarrhythmic drug (AAD) therapy for atrial fibrillation (AF) can be associated with both proarrhythmic and noncardiovascular toxicities. Practice guidelines recommend tailored AAD therapy for AF based on patient-specific characteristics, such ... Full text Link to item Cite

Clinical Characteristics and Outcomes Associated With Oral Anticoagulant Use Among Patients Hospitalized With Intracerebral Hemorrhage.

Journal article JAMA Netw Open · February 1, 2021 IMPORTANCE: Although the use of factor Xa (FXa) inhibitors has increased substantially over the past decade, there are limited data on characteristics and outcomes of FXa inhibitor-associated intracerebral hemorrhage (ICH). OBJECTIVE: To investigate the as ... Full text Link to item Cite

2021 ISHNE/HRS/EHRA/APHRS Expert Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society.

Journal article Circ Arrhythm Electrophysiol · February 2021 This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society describes the current status of mobile health technologies in ... Full text Link to item Cite

Catheter ablation and healthcare utilization and cost among patients with paroxysmal versus persistent atrial fibrillation.

Journal article Heart Rhythm O2 · February 2021 BACKGROUND: Ablation reduces atrial fibrillation (AF) burden and improves health-related quality of life. The relationship between ablation, healthcare utilization, and AF type (paroxysmal AF [PAF] vs persistent AF [PsAF]) remains unclear. OBJECTIVE: To co ... Full text Link to item Cite

2021 ISHNE/HRS/EHRA/APHRS Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society.

Journal article Cardiovasc Digit Health J · February 2021 This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society describes the current status of mobile health ("mHealth") tech ... Full text Link to item Cite

Research Priorities in Atrial Fibrillation Screening: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop.

Journal article Circulation · January 26, 2021 Clinically recognized atrial fibrillation (AF) is associated with higher risk of complications, including ischemic stroke, cognitive decline, heart failure, myocardial infarction, and death. It is increasingly recognized that AF frequently is undetected un ... Full text Link to item Cite

Impact of the COVID-19 pandemic on patterns of outpatient cardiovascular care.

Journal article Am Heart J · January 2021 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic brought about abrupt changes in the way health care is delivered, and the impact of transitioning outpatient clinic visits to telehealth visits on processes of care and outcomes is unclear. METHO ... Full text Link to item Cite

Interpretable morphological features for efficient single-lead automatic ventricular ectopy detection.

Journal article J Electrocardiol · 2021 OBJECTIVE: We designed an automatic, computationally efficient, and interpretable algorithm for detecting ventricular ectopic beats in long-term, single-lead electrocardiogram recordings. METHODS: We built five simple, interpretable, and computationally ef ... Full text Link to item Cite

2021 ishne/hrs/ehra/aphrs collaborative statement on mhealth in arrhythmia management:Digital medical tools for heart rhythm professionals

Journal article Russian Journal of Cardiology · January 1, 2021 This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society describes the current status of mobile health (“mHealth”) tech ... Full text Cite

Flavonoid intake and its association with atrial fibrillation.

Journal article Clin Nutr · December 2020 BACKGROUND & AIMS: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was t ... Full text Link to item Cite

Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

Journal article J Cardiovasc Transl Res · December 2020 COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbid ... Full text Open Access Link to item Cite

Predictors of atrial mechanical sensing and atrioventricular synchrony with a leadless ventricular pacemaker: Results from the MARVEL 2 Study.

Journal article Heart Rhythm · December 2020 BACKGROUND: The MARVEL (Micra Atrial TRacking Using a Ventricular AccELerometer) 2 study assessed the efficacy of atrioventricular (AV) synchronous pacing with a Micra leadless pacemaker. Average atrioventricular synchrony (AVS) was 89.2%. Previously, low ... Full text Link to item Cite

Morbidity and mortality in patients precluded for transvenous pacemaker implantation: Experience with a leadless pacemaker.

Journal article Heart Rhythm · December 2020 BACKGROUND: The Micra transcatheter pacemaker is a safe and effective alternative to transvenous permanent pacemakers (TV-PPMs). However, the safety profile and mortality outcomes of Micra implantation in patients deemed poor candidates for TV-PPM are inco ... Full text Link to item Cite

Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium.

Journal article Eur J Heart Fail · December 2020 The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food ... Full text Link to item Cite

Healthcare utilization and cost in patients with atrial fibrillation and heart failure undergoing catheter ablation.

Journal article J Cardiovasc Electrophysiol · December 2020 BACKGROUND: Catheter ablation is an effective treatment for patients with atrial fibrillation (AF) and heart failure (HF). However, little is known about how healthcare utilization and cost change after ablation in this population. We sought to determine h ... Full text Link to item Cite

Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation.

Journal article Heart · December 2020 OBJECTIVE: To investigate changes in quality of life (QoL), cognition and functional status according to arrhythmia recurrence after atrial fibrillation (AF) ablation. METHODS: We compared QoL, cognition and functional status in patients with recurrent atr ... Full text Link to item Cite

VVI pacing with normal QRS duration and ventricular function: MOST trial findings relevant to leadless pacemakers.

Journal article Pacing Clin Electrophysiol · December 2020 BACKGROUND: Leadless pacemakers (LPs) provide ventricular pacing without the risks associated with transvenous leads and device pockets. LPs are appealing for patients who need pacing, but do not need defibrillator or cardiac resynchronization therapy. Mos ... Full text Open Access Link to item Cite

Patient-reported outcomes and subsequent management in atrial fibrillation clinical practice: Results from the Utah mEVAL AF program.

Journal article J Cardiovasc Electrophysiol · December 2020 BACKGROUND: Atrial fibrillation (AF) significantly reduces health-related quality of life (HRQoL), previously measured in clinical trials using patient-reported outcomes (PROs). We examined AF PROs in clinical practice and their association with subsequent ... Full text Link to item Cite

Management of Atrial Fibrillation in Older Patients by Morbidity Burden: Insights From Get With The Guidelines-Atrial Fibrillation.

Journal article J Am Heart Assoc · December 2020 Background Knowledge is scarce regarding how multimorbidity is associated with therapeutic decisions regarding oral anticoagulants (OACs) in patients with atrial fibrillation. Methods and Results We conducted a cross-sectional study of hospitalized patient ... Full text Open Access Link to item Cite

Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium.

Journal article JACC Heart Fail · December 2020 The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food ... Full text Link to item Cite

Economic Evaluation of Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure With Reduced Ejection Fraction.

Journal article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Randomized clinical trials have demonstrated that catheter ablation for atrial fibrillation in patients with heart failure with reduced ejection fraction may improve survival and other cardiovascular outcomes. METHODS: We constructed a decision ... Full text Link to item Cite

Abstract 14106: The Efficacy of Sodium Glucose Co-transporter 2 Inhibitors in Atrial Fibrillation: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Conference Circulation · November 17, 2020 Background: Atrial Fibrillation (AF) is common in patients with Type 2 diabetes mellitus and it is associated with adverse outcomes. The impact of SGLT-2 inhibitors on incident AF and cardiovascular o ... Full text Cite

Machine learning does not improve upon traditional regression in predicting outcomes in atrial fibrillation: an analysis of the ORBIT-AF and GARFIELD-AF registries.

Conference Europace · November 1, 2020 AIMS: Prediction models for outcomes in atrial fibrillation (AF) are used to guide treatment. While regression models have been the analytic standard for prediction modelling, machine learning (ML) has been promoted as a potentially superior methodology. W ... Full text Link to item Cite

Social Media Influence Does Not Reflect Scholarly or Clinical Activity in Real Life.

Journal article Circ Arrhythm Electrophysiol · November 2020 BACKGROUND: Social media has become a major source of communication in medicine. We aimed to understand the relationship between physicians' social media influence and their scholarly and clinical activity. METHODS: We identified attending US electrophysio ... Full text Link to item Cite

Stellate Ganglion Blockade: an Intervention for the Management of Ventricular Arrhythmias.

Journal article Curr Hypertens Rep · October 23, 2020 PURPOSE OF REVIEW: To highlight the indications, procedural considerations, and data supporting the use of stellate ganglion blockade (SGB) for management of refractory ventricular arrhythmias. RECENT FINDINGS: In patients with refractory ventricular arrhy ... Full text Open Access Link to item Cite

The prognostic value of diastolic and systolic mechanical left ventricular dyssynchrony among patients with coronary artery disease and heart failure.

Journal article J Nucl Cardiol · October 2020 BACKGROUND: Prevalence and prognostic value of diastolic and systolic dyssynchrony in patients with coronary artery disease (CAD) + heart failure (HF) or CAD alone are not well understood. METHODS: We included patients with gated single-photon emission com ... Full text Link to item Cite

Shared decision-making in atrial fibrillation: patient-reported involvement in treatment decisions.

Journal article Eur Heart J Qual Care Clin Outcomes · October 1, 2020 AIMS: To determine the extent of shared decision-making (SDM), during selection of oral anticoagulant (OAC) and rhythm control treatments, in patients with newly diagnosed atrial fibrillation (AF). METHODS AND RESULTS: We evaluated survey data from 1006 pa ... Full text Link to item Cite

Effect of Temporary Interruption of Warfarin Due to an Intervention on Downstream Time in Therapeutic Range in Patients With Atrial Fibrillation (from ORBIT AF).

Journal article Am J Cardiol · October 1, 2020 The aim of this study was to quantify time in therapeutic range (TTR) before and after a temporary interruption of warfarin due to an intervention in the Outcomes Registry for Better Informed Treatment of atrial fibrillation (AF). AF patients on warfarin w ... Full text Link to item Cite

Subcutaneous implantable cardioverter-defibrillator troubleshooting in patients with a left ventricular assist device: A case series and systematic review.

Journal article Heart Rhythm · September 2020 BACKGROUND: There are limited data on the performance of the subcutaneous implantable cardioverter-defibrillator (S-ICD) in patients with a left ventricular assist device (LVAD). OBJECTIVE: The purpose of this study was to describe the clinical course and ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in cardiac amyloidosis.

Journal article Pacing Clin Electrophysiol · September 2020 BACKGROUND: Cardiac amyloidosis is a progressive infiltrative disease involving deposition of amyloid fibrils in the myocardium and cardiac conduction system that frequently manifests with heart failure (HF) and arrhythmias, most frequently atrial fibrilla ... Full text Link to item Cite

Procedural Patterns and Safety of Atrial Fibrillation Ablation: Findings From Get With The Guidelines-Atrial Fibrillation.

Journal article Circ Arrhythm Electrophysiol · September 2020 BACKGROUND: Catheter ablation is an increasingly used treatment for symptomatic atrial fibrillation (AF). However, there are limited prospective, nationwide data on patient selection and procedural characteristics. This study describes patient characterist ... Full text Link to item Cite

Predictors of recurrence of atrial fibrillation within the first 3 months after ablation.

Journal article Europace · September 1, 2020 AIMS: Freedom from atrial fibrillation (AF) at 1 year can be achieved in 50-70% of patients undergoing catheter ablation. Recurrent AF early after ablation most commonly terminates spontaneously without further interventional treatment but is associated wi ... Full text Link to item Cite

Cardiovascular Implantable Electronic Device Surgery Following Left Ventricular Assist Device Implantation.

Journal article JACC Clin Electrophysiol · September 2020 OBJECTIVES: This study sought to determine the indications, characteristics, and outcomes of cardiovascular implantable electronic device (CIED) surgery in patients with LVAD. BACKGROUND: Many patients with a left ventricular assist device (LVAD) will requ ... Full text Link to item Cite

Reducing ECG Artifact From Left Ventricular Assist Device Electromagnetic Interference.

Journal article J Am Heart Assoc · August 18, 2020 Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients w ... Full text Link to item Cite

Impact of interruptions in radiofrequency energy delivery on lesion characteristics.

Journal article Heart Rhythm · August 2020 BACKGROUND: During catheter ablation, delivery of radiofrequency (RF) energy to a target site is sometimes interrupted by catheter instability and clinical factors. The impact of interruption of RF delivery on lesion characteristics has not been characteri ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Journal article Heart Rhythm O2 · August 2020 BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. OBJECTIVE: The purpose of this study was to compa ... Full text Open Access Link to item Cite

Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).

Journal article Am Heart J · August 2020 UNLABELLED: While oral anticoagulation is a cornerstone of stroke prevention therapy in atrial fibrillation (AF), few studies have evaluated comparative discontinuation rates in clinical practice. The objective of this study is to evaluate discontinuation ... Full text Link to item Cite

Artificial Intelligence and Machine Learning in Arrhythmias and Cardiac Electrophysiology.

Journal article Circ Arrhythm Electrophysiol · August 2020 Artificial intelligence (AI) and machine learning (ML) in medicine are currently areas of intense exploration, showing potential to automate human tasks and even perform tasks beyond human capabilities. Literacy and understanding of AI/ML methods are becom ... Full text Link to item Cite

Risk of atrioesophageal fistula with cryoballoon ablation of atrial fibrillation.

Journal article Heart Rhythm O2 · August 2020 BACKGROUND: Although there are considerable data on the safety of cryoablation, data on the rare but severe complication of atrioesophageal fistula (AEF) following cryoballoon ablation are limited. OBJECTIVE: To report the global, user-reported incidence o ... Full text Link to item Cite

Hands on: How to approach patients undergoing lead extraction.

Journal article J Cardiovasc Electrophysiol · July 2020 Due to the growing number of patients treated with cardiac implantable electronic devices (CIEDs) there is an increased need for lead management, evaluation, and extraction. While CIED lead extraction has many indications, a consistent approach to preproce ... Full text Link to item Cite

Ablation of persistent atrial fibrillation: Challenges and solutions.

Journal article J Cardiovasc Electrophysiol · July 2020 Catheter ablation is commonly used for treatment of persistent atrial fibrillation (AF). Pulmonary vein isolation (PVI) is still the cornerstone for the procedure, however, outcomes are consistently lower compared to paroxysmal AF. It is hypothesized that ... Full text Link to item Cite

Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5.

Journal article Europace · July 1, 2020 AIMS: Study sex-differences in efficacy and safety of atrial fibrillation (AF) ablation. METHODS AND RESULTS: We assessed first AF ablation outcomes on continuous anticoagulation in 633 patients [209 (33%) women and 424 (67%) men] in a pre-specified subgro ... Full text Link to item Cite

Generalizability of the CASTLE-AF trial: Catheter ablation for patients with atrial fibrillation and heart failure in routine practice.

Journal article Heart Rhythm · July 2020 BACKGROUND: In the Catheter Ablation for Atrial Fibrillation with Heart Failure (CASTLE-AF) trial, catheter ablation reduced the risk of death and heart failure (HF) hospitalization in patients with atrial fibrillation and HF by 40%. OBJECTIVES: The study ... Full text Link to item Cite

A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response.

Journal article Am Heart J · July 2020 The infection caused by severe acute respiratory syndrome coronavirus-2, or COVID-19, can result in myocardial injury, heart failure, and arrhythmias. In addition to the viral infection itself, investigational therapies for the infection can interact with ... Full text Link to item Cite

Implantable cardioverter-defibrillator lead revision following left ventricular assist device implantation.

Journal article J Cardiovasc Electrophysiol · June 2020 INTRODUCTION: Lead dysfunction can lead to serious consequences including failure to treat ventricular tachycardia or fibrillation (VT/VF). The incidence and mechanisms of lead dysfunction following left ventricular assist device (LVAD) implantation are no ... Full text Link to item Cite

Predictors of Cardiac Perforation With Catheter Ablation of Atrial Fibrillation.

Journal article JACC Clin Electrophysiol · June 2020 OBJECTIVES: This study identified factors associated with risk for cardiac perforation in the setting of atrial fibrillation (AF) ablation in contemporary clinical practice. BACKGROUND: Cardiac perforation is an uncommon but potentially fatal complication ... Full text Link to item Cite

Lead Extraction for Cardiovascular Implantable Electronic Device Infection in Patients With Left Ventricular Assist Devices.

Journal article JACC Clin Electrophysiol · June 2020 OBJECTIVES: The goal of this study was to assess the utility of transvenous lead extraction for cardiovascular implantable electronic device (CIED) infection in patients with a left ventricular assist device (LVAD). BACKGROUND: The use of transvenous lead ... Full text Link to item Cite

The reward of understanding risk in atrial fibrillation.

Journal article European journal of preventive cardiology · May 13, 2020 Full text Cite

Risk of major cardiovascular and neurologic events with obstructive sleep apnea among patients with atrial fibrillation.

Journal article Am Heart J · May 2020 BACKGROUND: Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF). However, it remains unclear whether OSA is independently associated with worse cardiovascular and neurological outcomes in patients with AF. METHODS: We used the ... Full text Link to item Cite

Factors Associated With Large Improvements in Health-Related Quality of Life in Patients With Atrial Fibrillation: Results From ORBIT-AF.

Journal article Circ Arrhythm Electrophysiol · May 2020 BACKGROUND: Atrial fibrillation (AF) adversely impacts health-related quality of life (hrQoL). While some patients demonstrate improvements in hrQoL, the factors associated with large improvements in hrQoL are not well described. METHODS: We assessed facto ... Full text Link to item Cite

Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias.

Journal article JACC Clin Electrophysiol · May 2020 OBJECTIVES: This study sought to describe our institutional experience with establishing a neurocardiology service in an attempt to provide autonomic modulation as a treatment for ventricular arrhythmias (VAs). BACKGROUND: Treatment-refractory VAs are comm ... Full text Link to item Cite

'Real-world' observational studies in arrhythmia research: data sources, methodology, and interpretation. A position document from European Heart Rhythm Association (EHRA), endorsed by Heart Rhythm Society (HRS), Asia-Pacific HRS (APHRS), and Latin America HRS (LAHRS).

Journal article Europace · May 1, 2020 The field of observational studies or "real world studies" is in rapid development with many new techniques introduced and increased understanding of traditional methods. For this reason the current paper provides an overview of current methods with focus ... Full text Link to item Cite

Outcomes of Cardiac Catheterization in Patients With Atrial Fibrillation on Anticoagulation in Contemporary in Practice: An Analysis of the ORBIT II Registry.

Journal article Circ Cardiovasc Interv · May 2020 BACKGROUND: Patients with atrial fibrillation on oral anticoagulation (OAC) undergoing cardiac catheterization face risks for embolic and bleeding events, yet information on strategies to mitigate these risks in contemporary practice is lacking. METHODS: W ... Full text Link to item Cite

Use of left atrial appendage occlusion among older cardiac surgery patients with preoperative atrial fibrillation: a national cohort study.

Journal article J Interv Card Electrophysiol · April 2020 PURPOSE: Patients with atrial fibrillation (AF) undergoing cardiac surgery are at substantially increased risk for stroke. Increasing evidence has suggested that surgical left atrial appendage occlusion (S-LAAO) may have the potential to substantially miti ... Full text Link to item Cite

Amiodarone treatment in atrial fibrillation and the risk of incident cancers: A nationwide observational study.

Journal article Heart Rhythm · April 2020 BACKGROUND: In observational studies, case reports, and animal studies, amiodarone has been associated with incident cancer. OBJECTIVE: The purpose of this study was to examine whether a dose-response relationship between amiodarone use and the risk of can ... Full text Link to item Cite

Diagnosis-to-Ablation Time and Recurrence of Atrial Fibrillation Following Catheter Ablation: A Systematic Review and Meta-Analysis of Observational Studies.

Journal article Circ Arrhythm Electrophysiol · April 2020 BACKGROUND: The optimal timing of catheter ablation for atrial fibrillation (AF) in reference to the time of diagnosis is unknown. We sought to assess the impact of the duration between first diagnosis of AF and ablation, or diagnosis-to-ablation time (DAT ... Full text Link to item Cite

Focal impulse and rotor modulation of atrial rotors during atrial fibrillation leads to organization of left atrial activation as reflected by waveform morphology recurrence quantification analysis and organizational index.

Journal article J Arrhythm · April 2020 BACKGROUND: Focal impulse and rotor modulation (FIRM) can cause slowing, organization, and occasionally termination of atrial fibrillation (AF), although results have been mixed. To further characterize changes in AF during rotor ablation, we quantified mo ... Full text Link to item Cite

Oral Anticoagulation and Cardiovascular Outcomes in Patients With Atrial Fibrillation and End-Stage Renal Disease.

Journal article J Am Coll Cardiol · March 24, 2020 BACKGROUND: Atrial fibrillation (AF) is common in patients with end-stage renal disease (ESRD). The impact of oral anticoagulation (OAC) in ESRD patients is uncertain. OBJECTIVES: The purpose of this study was to describe patterns of OAC use in ESRD patien ... Full text Link to item Cite

PREDICTORS OF FFR UNDERUTILIZATION

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Strict Versus Lenient Versus Poor Rate Control Among Patients With Atrial Fibrillation and Heart Failure (from the Get With The Guidelines - Heart Failure Program).

Journal article Am J Cardiol · March 15, 2020 Randomized data suggest lenient rate control (resting heart rate <110 beats/min) is noninferior to strict rate control (resting heart rate <80 beats/min) in patients with atrial fibrillation (AF). However, the optimal rate control strategy in patients with ... Full text Link to item Cite

Complications involving the subcutaneous implantable cardioverter-defibrillator: Lessons learned from MAUDE.

Journal article Heart Rhythm · March 2020 BACKGROUND: Reports on the subcutaneous implantable cardioverter-defibrillator (S-ICD) cumulatively demonstrate a low rate of complications, but clinical experience with this technology is limited compared with transvenous devices. OBJECTIVE: The purpose o ... Full text Link to item Cite

Systematic collection of patient-reported outcomes in atrial fibrillation: feasibility and initial results of the Utah mEVAL AF programme.

Journal article Europace · March 1, 2020 AIMS: Incorporating patient-reported outcomes (PROs) into routine care of atrial fibrillation (AF) enables direct integration of symptoms, function, and health-related quality of life (HRQoL) into practice. We report our initial experience with a system-wi ... Full text Link to item Cite

Decline in renal function and oral anticoagulation dose reduction among patients with atrial fibrillation.

Journal article Heart · March 2020 OBJECTIVE: Non-vitamin K oral anticoagulants (NOACs) require dose adjustment for renal function. We sought to investigate change in renal function over time in patients with atrial fibrillation (AF) and whether those on NOACs have appropriate dose adjustme ... Full text Link to item Cite

Preprocedural computed tomography before cardiac implanted electronic device lead extraction: Indication, technique, and approach to interpretation.

Journal article J Cardiovasc Electrophysiol · March 2020 Cardiac implantable electronic devices (CIEDs) frequently need to be extracted due to infection, hardware failure, and other causes. The extraction of the CIED is typically performed using percutaneous methods. While these procedures are mostly performed w ... Full text Link to item Cite

Research Needs and Priorities for Catheter Ablation of Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop.

Journal article Circulation · February 11, 2020 Catheter ablation has brought major advances in the management of patients with atrial fibrillation (AF). As evidenced by multiple randomized trials, AF catheter ablation can reduce the risk of recurrent AF and improve quality of life. In some studies, AF ... Full text Link to item Cite

Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.

Journal article Am Heart J · February 2020 BACKGROUND: Pulmonary wall isolation (PWI) is increasingly used as an adjunctive lesion set to compliment pulmonary vein isolation (PVI), especially in patients with persistent atrial fibrillation (AF). The objective was to compare outcomes of catheter abl ... Full text Link to item Cite

Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation.

Journal article Am Heart J · February 2020 BACKGROUND: Amiodarone is the most effective antiarrhythmic drug (AAD) for atrial fibrillation (AF), but it has a high incidence of adverse effects. METHODS: Using the ORBIT AF registry, patients with AF on amiodarone at enrollment, prescribed amiodarone d ... Full text Link to item Cite

Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.

Journal article J Arrhythm · February 2020 BACKGROUND: Catheter ablation is an important rhythm control therapy in patients with atrial fibrillation (AF) with concomitant heart failure (HF). The objective of this study was to assess the comparative efficacy of AF ablation patients with ischemic vs ... Full text Open Access Link to item Cite

Additional antitachycardia pacing programming strategies further reduce unnecessary implantable cardioverter-defibrillator shocks.

Journal article Heart rhythm · January 2020 BackgroundAntitachycardia pacing (ATP) is routinely used to terminate ventricular tachyarrhythmias (VTs). However, little guidance exists on the most effective programming of ATP.ObjectiveThis study evaluated whether additional ATP sequen ... Full text Cite

Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation.

Journal article Am Heart J · January 2020 BACKGROUND: Comorbidities are common in patients with atrial fibrillation (AF) and affect prognosis, yet are often undertreated. However, contemporary rates of use of guideline-directed therapies (GDT) for non-AF comorbidities and their association with ou ... Full text Link to item Cite

Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker: Results From the MARVEL 2 Study.

Journal article JACC Clin Electrophysiol · January 2020 OBJECTIVES: This study reports on the performance of a leadless ventricular pacemaker with automated, enhanced accelerometer-based algorithms that provide atrioventricular (AV) synchronous pacing. BACKGROUND: Despite many advantages, leadless pacemakers ar ... Full text Link to item Cite

Rhythm Control Versus Rate Control in Patients With Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction: Insights From Get With The Guidelines-Heart Failure.

Journal article J Am Heart Assoc · December 17, 2019 Background Limited data exist to guide treatment for patients with heart failure with preserved ejection fraction and atrial fibrillation, including the important decision regarding rate versus rhythm control. Methods and Results We analyzed the Get With T ... Full text Link to item Cite

Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis.

Journal article J Clin Sleep Med · December 15, 2019 STUDY OBJECTIVES: Early evidence with transvenous phrenic nerve stimulation (PNS) demonstrates improved disease severity and quality of life (QOL) in patients with central sleep apnea (CSA). The goal of this analysis is to evaluate the complete prospective ... Full text Link to item Cite

Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF.

Journal article Cardiol Ther · December 2019 INTRODUCTION: Patient-reported outcomes (PROs) and satisfaction endpoints are increasingly important in clinical trials and may be associated with treatment adherence. In this post hoc substudy from ROCKET AF, we examined whether patient-reported satisfact ... Full text Link to item Cite

Left atrial appendage closure: A therapy uniquely suited for specific populations of patients with atrial fibrillation.

Journal article J Cardiovasc Electrophysiol · December 2019 Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and confers a fivefold increased risk for stroke. Cardioembolic stroke secondary to AF is a devastating event, but is largely preventable with appropriate oral anticoagulation (OAC) ... Full text Link to item Cite

Outcomes and Anticoagulation Use After Catheter Ablation for Atrial Fibrillation.

Journal article Circ Arrhythm Electrophysiol · December 2019 BACKGROUND: Studies evaluating the effects of atrial fibrillation (AF) catheter ablation versus antiarrhythmic therapy on outcomes have shown mixed results. In addition, guidelines recommend continuing oral anticoagulation (OAC) after ablation for those at ... Full text Link to item Cite

Ischemic and Bleeding Outcomes in Patients With Atrial Fibrillation and Contraindications to Oral Anticoagulation.

Journal article JACC Clin Electrophysiol · December 2019 OBJECTIVES: This study sought to describe clinical outcomes among patients with atrial fibrillation (AF) and contraindications to oral anticoagulation (OAC). BACKGROUND: Treatment with OAC prevents stroke and death in patients with AF, but may be contraind ... Full text Link to item Cite

Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation-Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF).

Journal article BMJ open · December 2019 PurposeBesides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objectiv ... Full text Cite

Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration.

Journal article Circulation · November 26, 2019 Cardiac thromboembolism attributed to atrial fibrillation (AF) is responsible for up to one-third of ischemic strokes. Stroke may be the first manifestation of previously undetected AF. Given the efficacy of oral anticoagulants in preventing AF-related isc ... Full text Link to item Cite

Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis.

Journal article J Clin Sleep Med · November 5, 2019 STUDY OBJECTIVES: Early evidence with transvenous phrenic nerve stimulation (PNS) demonstrates improved disease severity and quality of life (QOL) in patients with central sleep apnea (CSA). The goal of this analysis is to evaluate the complete prospective ... Link to item Cite

Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.

Journal article Pacing Clin Electrophysiol · November 2019 BACKGROUND: Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence af ... Full text Open Access Link to item Cite

Patient selection, pacing indications, and subsequent outcomes with de novo leadless single-chamber VVI pacing.

Journal article Europace · November 1, 2019 AIMS: Patient selection is a key component of securing optimal patient outcomes with leadless pacing. We sought to describe and compare patient characteristics and outcomes of Micra patients with and without a primary pacing indication associated with atri ... Full text Link to item Cite

Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation.

Journal article J Cardiovasc Electrophysiol · October 2019 INTRODUCTION: Little is known about how genetic predisposition and fibrosis relate in atrial fibrillation (AF). Hence, we sought to determine whether the genetic variants and biomarkers for fibrosis enhance prediction of outcomes after catheter ablation. M ... Full text Link to item Cite

A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation.

Journal article Am J Cardiol · September 15, 2019 Recently, cluster analysis was used to identify unique clinically relevant phenotypes of atrial fibrillation (AF) in a cohort from the United States (US) and classified clusters according to the presence of comorbid behavioral disorders, those with conduct ... Full text Link to item Cite

Machine learning in 'big data': handle with care.

Journal article Europace · September 1, 2019 Full text Link to item Cite

Watchman implantation in a patient with left atrial appendage thrombus.

Journal article J Cardiovasc Electrophysiol · September 2019 Full text Link to item Cite

Atrial Fibrillation and Diabetes Mellitus: JACC Review Topic of the Week.

Journal article J Am Coll Cardiol · August 27, 2019 Diabetes mellitus is one of the most common chronic medical conditions, and is a risk factor for the development of atrial fibrillation (AF). The presence of diabetes in patients with AF is associated with increased symptom burden and increased cardiovascu ... Full text Link to item Cite

Big data in remote monitoring

Book section · August 14, 2019 Cite

Incidence and outcomes of systemic infections in patients with leadless pacemakers: Data from the Micra IDE study.

Journal article Pacing Clin Electrophysiol · August 2019 BACKGROUND: The Micra clinical trials have enrolled more than 2500 patients without any reported device-related infections that required removal during follow-up. Leadless pacemakers might be more resistant to bacterial seeding due to smaller surface area ... Full text Link to item Cite

Association Between Warfarin Control Metrics and Atrial Fibrillation Outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation.

Journal article JAMA Cardiol · August 1, 2019 IMPORTANCE: Bleeding and thrombotic events (eg, stroke and systemic embolism) are common in patients with atrial fibrillation (AF) taking warfarin sodium despite a well-established therapeutic range. OBJECTIVE: To evaluate whether history of therapeutic wa ... Full text Link to item Cite

Atrial Fibrillation and Percutaneous Coronary Intervention.

Journal article Circ Cardiovasc Interv · August 2019 Full text Link to item Cite

Neuromodulation for the Treatment of Heart Rhythm Disorders.

Journal article JACC Basic Transl Sci · August 2019 There is an increasing recognition of the importance of interactions between the heart and the autonomic nervous system in the pathophysiology of arrhythmias. These interactions play a role in both the initiation and maintenance of arrhythmias and are impo ... Full text Link to item Cite

The Prognostic Value of Diastolic and Systolic Mechanical Left Ventricular Dyssynchrony Among Patients With Coronary Heart Disease.

Conference JACC Cardiovasc Imaging · July 2019 OBJECTIVES: The goal of this study was to examine whether diastolic dyssynchrony, measured by using gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in patients with coronary artery disease (CAD), is independentl ... Full text Link to item Cite

Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial.

Journal article JACC Heart Fail · July 2019 OBJECTIVES: The purpose of this study was to compare the effectiveness of bucindolol with that of metoprolol succinate for the maintenance of sinus rhythm in a genetically defined heart failure (HF) population with atrial fibrillation (AF). BACKGROUND: Buc ... Full text Link to item Cite

Treatment of atrial fibrillation with concomitant coronary or peripheral artery disease: Results from the outcomes registry for better informed treatment of atrial fibrillation II.

Journal article Am Heart J · July 2019 BACKGROUND: Treatment patterns and outcomes of individuals with vascular disease who have new-onset atrial fibrillation (AF) are not well characterized. METHODS: Among patients with new-onset AF, we analyzed treatment and outcomes in those with or without ... Full text Link to item Cite

Application of net reclassification index to non-nested and point-based risk prediction models: a review.

Journal article European heart journal · June 2019 Much of medical risk prediction involves externally derived prediction equations, nomograms, and point-based risk scores. These settings are vulnerable to misleading findings of incremental value based on versions of the net reclassification index (NRI) in ... Full text Cite

Heart Failure and Atrial Fibrillation, Like Fire and Fury.

Journal article JACC. Heart failure · June 2019 Heart failure and atrial fibrillation are 2 common cardiovascular disorders that frequently complicate one another and exert a significant detrimental effect on cardiovascular health and well-being. Both heart failure and atrial fibrillation continue to in ... Full text Cite

Practice Variation in Anticoagulation Prescription and Outcomes After Device-Detected Atrial Fibrillation.

Journal article Circulation · May 28, 2019 BACKGROUND: Device-detected atrial fibrillation (AF) is associated with increased risk of stroke; however, there are no clearly defined thresholds of AF burden at which to initiate oral anticoagulation (OAC). We sought to describe OAC prescription practice ... Full text Link to item Cite

Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry).

Journal article Am J Cardiol · May 15, 2019 Systolic blood pressure (SBP) and its association with clinical outcomes in atrial fibrillation (AF) patients in community practice are poorly characterized. In patients with AF, we sought to (1) examine the prevalence of baseline uncontrolled hypertension ... Full text Link to item Cite

Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT - AF Registry.

Journal article J Am Heart Assoc · May 7, 2019 Background Patient satisfaction with therapy is an important metric of care quality and has been associated with greater medication persistence. We evaluated the association of patient satisfaction with warfarin therapy to other metrics of anticoagulation ... Full text Link to item Cite

Randomized Clinical Trials of Catheter Ablation of Atrial Fibrillation in Congestive Heart Failure: Knowns and Unmet Needs.

Journal article Cardiol Clin · May 2019 Atrial fibrillation (AF) and heart failure (HF) are conditions that frequently coexist and are associated with worse outcomes compared with either condition alone. Although rhythm control with antiarrhythmic drug treatment is not superior to rate control i ... Full text Link to item Cite

Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation.

Journal article Am Heart J · May 2019 BACKGROUND: The incidence of cognitive impairment and frailty increase with age and may impact both therapy and outcomes in atrial fibrillation (AF). METHODS: We examined the prevalence of clinically recognized cognitive impairment and frailty (as defined ... Full text Link to item Cite

Tackling Patient-Reported Outcomes in Atrial Fibrillation and Heart Failure: Identifying Disease-Specific Symptoms?

Journal article Cardiol Clin · May 2019 Atrial fibrillation (AF) and heart failure (HF) both significantly affect morbidity and mortality and also account for high symptom burden and impaired health-related quality of life (hrQoL). Several well-designed and broadly implemented patient-reported o ... Full text Link to item Cite

Patient-Reported Outcomes in Atrial Fibrillation Research: Results of a Clinicaltrials.gov Analysis.

Journal article JACC Clin Electrophysiol · May 2019 OBJECTIVES: This study sought to determine how frequently patient-reported outcomes (PROs) are collected in registered clinical studies of atrial fibrillation (AF). BACKGROUND: Improving symptom burden and quality of life are important goals in the treatme ... Full text Link to item Cite

Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.

Journal article Circ Cardiovasc Qual Outcomes · May 2019 Background The Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire has recently been validated to measure the impact of atrial fibrillation on quality of life, but a clinically important difference in AFEQT score has not been well defined. ... Full text Link to item Cite

Atrial fibrillation ablation in practice: assessing CABANA generalizability.

Journal article Eur Heart J · April 21, 2019 AIMS: The Catheter Ablation vs. Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial aimed to assess the impact of ablation on morbidity and mortality. This observational study was conducted in parallel to CABANA to assess trial generalizabil ... Full text Link to item Cite

New high-density and automated mapping systems

Book section · April 5, 2019 Three-dimensional electroanatomical mapping (EAM) systems realistically made it feasible to map focal or reentrant arrhythmias from one of the cardiac chambers. The importance of optimized detailed and accurate mapping within the regions previously conside ... Full text Cite

Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal article JAMA · April 2, 2019 IMPORTANCE: Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain. OBJECTIVE: To determine whether catheter abla ... Full text Link to item Cite

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal article JAMA · April 2, 2019 IMPORTANCE: Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain. OBJECTIVE: To determine whether catheter ablation is more effective than conventional me ... Full text Open Access Link to item Cite

Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF.

Journal article Eur Heart J Qual Care Clin Outcomes · April 1, 2019 AIMS: The management of anticoagulation therapy in patients with atrial fibrillation (AF) and cancer is challenging due to increased thrombotic and bleeding risks. We sought to determine the safety and efficacy of rivaroxaban in patients with AF and a hist ... Full text Link to item Cite

Leadless pacemaker implant in patients with pre-existing infections: Results from the Micra postapproval registry.

Journal article J Cardiovasc Electrophysiol · April 2019 INTRODUCTION: Leadless pacemakers may provide a safe and attractive pacing option to patients with cardiac implantable electronic device (CIED) infection. We describe the characteristics and outcomes of patients with a recent CIED infection undergoing Micr ... Full text Link to item Cite

The Prevalence and Impact of Atrial Fibrillation on 1-Year Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article JACC Cardiovasc Interv · March 25, 2019 OBJECTIVES: The aim of this study was to compare 1-year outcomes following transcatheter mitral valve (MV) repair in patients with and without atrial fibrillation (AF). BACKGROUND: The development of AF in degenerative mitral regurgitation (MR) is consider ... Full text Link to item Cite

Adherence to Guideline-Directed Stroke Prevention Therapy for Atrial Fibrillation Is Achievable.

Journal article Circulation · March 19, 2019 BACKGROUND: Efforts to improve prescription of oral anticoagulation (OAC) drugs in patients with atrial fibrillation have had limited success in improving guideline adherence. METHODS: We evaluated adherence to the American College of Cardiology/American H ... Full text Link to item Cite

B-type natriuretic peptide, disease progression and clinical outcomes in atrial fibrillation.

Journal article Heart · March 2019 OBJECTIVE: The association with B-type natriuretic peptide (BNP), disease progression and outcomes in patients with atrial fibrillation (AF) has not been thoroughly investigated. METHODS: We evaluated the association between BNP levels and outcomes, includ ... Full text Link to item Cite

Atrial fibrillation burden, progression, and the risk of death: a case-crossover analysis in patients with cardiac implantable electronic devices.

Journal article Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · March 2019 AimsAtrial fibrillation (AF) is associated with increased mortality, but the temporal relationship between AF burden (AFB) and death among patients with cardiac implanted electronic devices is unknown. We sought to characterize the timing and prog ... Full text Cite

Temporary autonomic modulation with botulinum toxin type A to reduce atrial fibrillation after cardiac surgery.

Journal article Heart Rhythm · February 2019 BACKGROUND: Postoperative atrial fibrillation (POAF) frequently complicates cardiac surgery and is associated with worse outcomes. The cardiac autonomic nervous system is implicated in the pathogenesis of POAF. OBJECTIVE: The purpose of this study was to d ... Full text Link to item Cite

Leadless Pacemaker Implantation in Hemodialysis Patients: Experience With the Micra Transcatheter Pacemaker.

Journal article JACC Clin Electrophysiol · February 2019 OBJECTIVES: This study sought to report periprocedural outcomes and intermediate-term follow-up of hemodialysis patients undergoing Micra implantation. BACKGROUND: Leadless pacemakers may be preferred in patients with limited vascular access and high-infec ... Full text Link to item Cite

Adaptive servo-ventilation reduces atrial fibrillation burden in patients with heart failure and sleep apnea.

Journal article Heart Rhythm · January 2019 BACKGROUND: Patients with heart failure and sleep apnea are at increased risk for developing arrhythmias. Whether treatment of sleep apnea reduces arrhythmias is unknown. OBJECTIVE: The purpose of this study was to determine whether adaptive servo-ventilat ... Full text Link to item Cite

Incremental prognostic value of renal function for stroke prediction in atrial fibrillation.

Journal article Int J Cardiol · January 1, 2019 BACKGROUND: Renal function has been associated with an increased stroke risk in patients with atrial fibrillation (AF). However, whether renal function incrementally adds to risk prediction in both anticoagulated and non-anticoagulated patients with AF is ... Full text Link to item Cite

Harmonized outcome measures for use in atrial fibrillation patient registries and clinical practice: Endorsed by the Heart Rhythm Society Board of Trustees.

Journal article Heart Rhythm · January 2019 BACKGROUND: Atrial fibrillation (AF) affects an estimated 33 million people worldwide, leading to increased mortality and an increased risk of heart failure and stroke. Many AF patient registries exist, but the ability to link and compare data across regis ... Full text Link to item Cite

Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.

Journal article J Cardiothorac Vasc Anesth · January 2019 Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and increased hospital and intensive care unit length of stay. Despite progressive improvements in overal ... Full text Link to item Cite

Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.

Journal article Anesth Analg · January 2019 Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac ... Full text Link to item Cite

Updated performance of the Micra transcatheter pacemaker in the real-world setting: A comparison to the investigational study and a transvenous historical control.

Journal article Heart Rhythm · December 2018 BACKGROUND: Early results of the Micra Investigational Device Exemption (IDE) study and Micra Post-Approval Registry (PAR) demonstrated excellent safety and efficacy performance; however, intermediate-term results across a large patient population in the r ... Full text Link to item Cite

Cognitive dysfunction in atrial fibrillation.

Journal article Nat Rev Cardiol · December 2018 Atrial fibrillation (AF) is the most common arrhythmia in adults, and its incidence and prevalence increase with age. The risk of cognitive impairment and dementia also increases with age, and both AF and cognitive impairment or dementia share important ri ... Full text Link to item Cite

Association of Race/Ethnicity With Oral Anticoagulant Use in Patients With Atrial Fibrillation: Findings From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II.

Journal article JAMA Cardiol · December 1, 2018 IMPORTANCE: Black and Hispanic patients are less likely than white patients to use oral anticoagulants for atrial fibrillation. Little is known about racial/ethnic differences in use of direct-acting oral anticoagulants (DOACs) for atrial fibrillation. OBJ ... Full text Link to item Cite

Embolic and Other Adverse Outcomes in Symptomatic Versus Asymptomatic Patients With Atrial Fibrillation (from the ORBIT-AF Registry).

Journal article Am J Cardiol · November 15, 2018 Asymptomatic atrial fibrillation (AF) is being increasingly diagnosed via implantable devices, screening, and inpatient telemetry. Management of asymptomatic AF is controversial, in part, because the associated risks have not been well described. We examin ... Full text Link to item Cite

Obstructive sleep apnea is associated with increased rotor burden in patients undergoing focal impulse and rotor modification guided atrial fibrillation ablation.

Journal article Europace · November 1, 2018 AIMS: To assess whether obstructive sleep apnea (OSA) was associated with increased rotor burden among atrial fibrillation (AF) patients. METHODS AND RESULTS: We studied 33 consecutive patients who were scheduled for focal impulse and rotor modulation (FIR ... Full text Link to item Cite

Characteristics and outcomes of adults with chronic obstructive pulmonary disease and atrial fibrillation.

Journal article Heart · November 2018 OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with the development of atrial fibrillation (AF), and may complicate treatment of AF. We examined the association between COPD and symptoms, quality of life (QoL), treatment and outcomes ... Full text Link to item Cite

Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article J Thromb Thrombolysis · November 2018 Anticoagulation is highly effective for the prevention of stroke in patients with atrial fibrillation (AF) but it is dependent on patients continuing therapy. While studies have demonstrated suboptimal therapeutic persistence on warfarin, few have studied ... Full text Link to item Cite

Single vs. dual chamber implantable cardioverter-defibrillators or programming of implantable cardioverter-defibrillators in patients without a bradycardia pacing indication: systematic review and meta-analysis.

Journal article Europace · October 1, 2018 AIMS: Implantable cardioverter-defibrillators (ICDs) are key in the prevention of sudden cardiac death, but outcomes may vary by type of device or programming [single chamber (SC) vs. dual chamber (DC)] in patients without a bradycardia pacing indication. ... Full text Link to item Cite

Use of Oral Anticoagulation in Eligible Patients Discharged With Heart Failure and Atrial Fibrillation.

Journal article Circ Heart Fail · October 2018 BACKGROUND: Stroke prophylaxis in patients with atrial fibrillation (AF) and heart failure (HF) in the era of direct oral anticoagulants is not well characterized. Using data from American Heart Association Get With The Guidelines-AFIB, we sought to evalua ... Full text Link to item Cite

Pharmacotherapy for Atrial Fibrillation in Patients With Chronic Kidney Disease: Insights From ORBIT-AF.

Journal article J Am Heart Assoc · September 18, 2018 Background Chronic kidney disease ( CKD ) is a common comorbidity in patients with atrial fibrillation. The presence of CKD complicates drug selection for stroke prevention and rhythm control. Methods and Results Patients enrolled in ORBIT AF (Outcomes Reg ... Full text Link to item Cite

Incidence, Management, and Associated Clinical Outcomes of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: An Analysis From the STS/ACC TVT Registry.

Journal article JACC Cardiovasc Interv · September 10, 2018 OBJECTIVES: The aim of this study was to evaluate incidence, care patterns, and clinical outcomes in patients developing new-onset atrial fibrillation (AF) following transcatheter aortic valve replacement (TAVR). BACKGROUND: Pre-procedural AF has been asso ... Full text Link to item Cite

Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation.

Journal article Circulation · August 28, 2018 BACKGROUND: Bleeding is commonly cited as a reason for stopping oral anticoagulants (OACs). Whether minor bleeding events (nuisance bleeding, NB) in patients with atrial fibrillation on OACs are associated with OAC discontinuation, major bleeding, and stro ... Full text Link to item Cite

Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation.

Journal article Eur Heart J · August 21, 2018 AIMS: It is recommended to perform atrial fibrillation ablation with continuous anticoagulation. Continuous apixaban has not been tested. METHODS AND RESULTS: We compared continuous apixaban (5 mg b.i.d.) to vitamin K antagonists (VKA, international normal ... Full text Link to item Cite

Stroke Risk and Treatment in Patients with Atrial Fibrillation and Low CHA2DS2-VASc Scores: Findings From the ORBIT-AF I and II Registries.

Journal article J Am Heart Assoc · August 21, 2018 Background Current American College of Cardiology/American Heart Association guidelines suggest that for patients with atrial fibrillation who are at low risk for stroke (CHA2DS2VASc=1) (or women with CHA2DS2VASc=2) a variety of treatment strategies may be ... Full text Open Access Link to item Cite

Selective Serotonin Reuptake Inhibitors and Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: An Analysis From the ROCKET AF Trial.

Conference J Am Heart Assoc · August 7, 2018 Background There is concern that selective serotonin reuptake inhibitors ( SSRI s) substantially increase bleeding risk in patients taking anticoagulants. Methods and Results We studied 737 patients taking SSRI s in the ROCKET AF (Rivaroxaban Once Daily Or ... Full text Link to item Cite

Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators: The RAID Trial.

Journal article J Am Coll Cardiol · August 7, 2018 BACKGROUND: Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs). OBJECTIVES: This study aimed to determine whether ranolazine administration decreases t ... Full text Link to item Cite

Predictive ability of perioperative atrial fibrillation risk indices in cardiac surgery patients: a retrospective cohort study.

Journal article Can J Anaesth · July 2018 PURPOSE: The Multicenter Study of Perioperative Ischemia (McSPI) AFRisk index predicts postoperative atrial fibrillation (POAF) after cardiac surgery, but requires pre-, intra-, and postoperative data. Other more abbreviated risk indices exist, but there i ... Full text Link to item Cite

Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT-AF.

Journal article J Am Heart Assoc · June 9, 2018 BACKGROUND: Oral anticoagulation (OAC) reduces stroke risk in atrial fibrillation, but bleeding is a frequent side effect. The decision to discontinue or modify medication regimens in response to a bleeding event may differ according to bleeding site and s ... Full text Link to item Cite

Impact of polyvascular disease on patients with atrial fibrillation: Insights from ROCKET AF.

Journal article Am Heart J · June 2018 BACKGROUND: We investigated the impact of polyvascular disease in patients enrolled in ROCKET AF. METHODS: Cox regression models were used to assess clinical outcomes and treatment effects of rivaroxaban compared with warfarin in patients with atrial fibri ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction.

Journal article Heart Rhythm · May 2018 BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). OBJECTIVE: The purpose of this study was to compare outcomes of AF ablation in pa ... Full text Link to item Cite

A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial.

Journal article Am Heart J · May 2018 BACKGROUND: Few therapies are available for the safe and effective treatment of atrial fibrillation (AF) in patients with heart failure. Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrh ... Full text Link to item Cite

Corrigendum

Journal article EP Europace · May 1, 2018 Full text Cite

Net clinical benefit of rivaroxaban compared with warfarin in atrial fibrillation: Results from ROCKET AF.

Journal article Int J Cardiol · April 15, 2018 AIMS: The aim of this study was to determine the net clinical benefit (NCB) of rivaroxaban compared with warfarin in patients with atrial fibrillation. METHODS: This was a retrospective analysis of 14,236 patients included in ROCKET AF who received at leas ... Full text Link to item Cite

Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry.

Journal article J Am Heart Assoc · April 13, 2018 BACKGROUND: Mineralocorticoid receptor antagonist (MRA) therapy may be beneficial to patients with atrial fibrillation (AF), but little is known about their use in patients with AF and subsequent outcomes. METHODS AND RESULTS: In order to better understand ... Full text Link to item Cite

Disease understanding in patients newly diagnosed with atrial fibrillation.

Journal article Heart · March 2018 OBJECTIVE: To describe self-reported disease understanding for newly diagnosed patients with atrial fibrillation (AF) and assess (1) how disease understanding changes over the first 6 months after diagnosis and (2) the relationship between patient understa ... Full text Link to item Cite

Frequency and Outcomes of Reduced Dose Non-Vitamin K Antagonist Anticoagulants: Results From ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II).

Journal article J Am Heart Assoc · February 16, 2018 BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are indicated for stroke prevention in atrial fibrillation (AF) but require lower doses in certain patients. We sought to describe the frequency, appropriateness (according to Food and Drug A ... Full text Link to item Cite

Reply: Graphing Ratio Measures on Forest Plot.

Journal article J Am Coll Cardiol · February 6, 2018 Full text Link to item Cite

Periprocedural Anticoagulation Management for Atrial Fibrillation Ablation: Current Knowledge and Future Directions.

Journal article Curr Treat Options Cardiovasc Med · January 25, 2018 Catheter ablation (CA) for atrial fibrillation (AF) is an established first-line approach to the management of drug-refractory AF. Although, advancements in procedural techniques and technology have improved the efficacy and safety of CA, thromboembolism ( ... Full text Link to item Cite

Association Between Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery.

Journal article JAMA · January 23, 2018 IMPORTANCE: The left atrial appendage is a key site of thrombus formation in atrial fibrillation (AF) and can be occluded or removed at the time of cardiac surgery. There is limited evidence regarding the effectiveness of surgical left atrial appendage occ ... Full text Link to item Cite

Left Atrial Appendage Electrical Isolation for Treatment of Recurrent Atrial Fibrillation: A Meta-Analysis.

Journal article JACC Clin Electrophysiol · January 2018 OBJECTIVES: In this study, the authors sought to perform a meta-analysis of controlled studies assessing the relationship between left atrial appendage (LAA) electrical isolation (EI) and recurrent atrial fibrillation (AF). BACKGROUND: LAA triggers could p ... Full text Link to item Cite

Association of of Atrial Fibrillation Clinical Phenotypes With Treatment Patterns and Outcomes: A Multicenter Registry Study.

Journal article JAMA Cardiol · January 1, 2018 IMPORTANCE: Atrial fibrillation (AF) is usually classified on the basis of the disease subtype. However, this characterization does not capture the full heterogeneity of AF, and a data-driven cluster analysis reveals different possible classifications of p ... Full text Link to item Cite

Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial.

Journal article Clin Cardiol · January 2018 BACKGROUND: Atrial fibrillation (AF) increases risk of stroke 5-fold. Carotid artery disease (CD) also augments the risk of stroke, yet there are limited data about the interplay of these 2 diseases and clinical outcomes in patients with comorbid AF and CD ... Full text Link to item Cite

Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF (Outcomes Registry for Better Informed Treatment for Atrial Fibrillation).

Journal article J Am Heart Assoc · December 22, 2017 BACKGROUND: The presence of valvular heart disease (VHD) may affect the risk of stroke and mortality in patients with atrial fibrillation (AF). Community-based estimates of prevalence and outcomes of specific forms of VHD in patients with AF are lacking. M ... Full text Link to item Cite

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

Journal article BMJ Open · December 21, 2017 OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was develop ... Full text Link to item Cite

Stellate ganglion blockade for the treatment of refractory ventricular arrhythmias: A systematic review and meta-analysis.

Journal article J Cardiovasc Electrophysiol · December 2017 INTRODUCTION: Treatment refractory ventricular arrhythmias (VAs) are often driven and exacerbated by heightened sympathetic tone. We aim to conduct a systematic review and meta-analysis of published studies of a temporary percutaneous stellate ganglion blo ... Full text Link to item Cite

Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure.

Journal article Curr Heart Fail Rep · December 2017 PURPOSE OF REVIEW: We explore the pharmacogenomics of the beta-blocker bucindolol by discussing relevant beta-1 adrenergic receptor (ADRB1) polymorphisms and recent beta-blocker studies. Through this, we will understand how bucindolol may help patients wit ... Full text Link to item Cite

International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries.

Journal article Am Heart J · December 2017 UNLABELLED: Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world. We aimed to provide comprehensive data on international patterns of AF stroke prevention treatment. METHODS: Demographics, comorbidities, and stroke risk of the patien ... Full text Link to item Cite

Outcome of Patients Receiving Thrombolytic Therapy While on Rivaroxaban for Nonvalvular Atrial Fibrillation (from Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation).

Journal article Am J Cardiol · November 15, 2017 The safety of intravenous thrombolysis in patients taking rivaroxaban has not been well established. We retrospectively analyzed the outcomes of all patients who received thrombolytic therapy in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition C ... Full text Link to item Cite

Treatment of Atrial Fibrillation and Concordance With the American Heart Association/American College of Cardiology/Heart Rhythm Society Guidelines: Findings From ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation).

Journal article Circulation. Arrhythmia and electrophysiology · November 2017 BackgroundIt is unclear how frequently patients with atrial fibrillation receive guideline-concordant (GC) care and whether guideline concordance is associated with improved outcomes.Methods and resultsUsing data from ORBIT-AF (Outcomes R ... Full text Cite

Antithrombotic therapy in atrial fibrillation associated with valvular heart disease: a joint consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology Working Group on Thrombosis, endorsed by the ESC Working Group on Valvular Heart Disease, Cardiac Arrhythmia Society of Southern Africa (CASSA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), South African Heart (SA Heart) Association and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).

Journal article Europace · November 1, 2017 Atrial fibrillation (AF) is a major worldwide public health problem, and AF in association with valvular heart disease (VHD) is also common. However, management strategies for this group of patients have been less informed by randomized trials, which have ... Full text Link to item Cite

Triple Therapy for Atrial Fibrillation after PCI.

Journal article N Engl J Med · October 19, 2017 Full text Link to item Cite

Impact of Tachyarrhythmia Detection Rate and Time from Detection to Shock on Outcomes in Nationwide US Practice.

Journal article Am J Cardiol · October 15, 2017 Although higher detection rates and delayed detection improve survival in implantable cardioverter defibrillator clinical trials, their effectiveness in clinical practice has limited validation. To evaluate the effectiveness of programming strategies for r ... Full text Link to item Cite

Outcomes Associated With Extraction Versus Capping and Abandoning Pacing and Defibrillator Leads.

Journal article Circulation · October 10, 2017 BACKGROUND: Lead management is an increasingly important aspect of care in patients with cardiac implantable electronic devices; however, relatively little is known about long-term outcomes after capping and abandoning leads. METHODS: Using the 5% Medicare ... Full text Link to item Cite

Care Patterns and Outcomes in Atrial Fibrillation Patients With and Without Diabetes: ORBIT-AF Registry.

Journal article J Am Coll Cardiol · September 12, 2017 BACKGROUND: Diabetes is a well-established risk factor for thromboembolism in patients with atrial fibrillation (AF), but less is known about how diabetes influences outcomes among AF patients. OBJECTIVES: This study assessed whether symptoms, health statu ... Full text Link to item Cite

Risk of atrioesophageal fistula formation with contact force-sensing catheters.

Journal article Heart Rhythm · September 2017 BACKGROUND: Atrioesophageal fistula formation is a rare but life-threatening complication of atrial fibrillation ablation. Contact force (CF)-sensing catheters improve procedural effectiveness. However, the impact of the implementation of CF-sensing techno ... Full text Link to item Cite

Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation.

Journal article Clin Cardiol · September 2017 BACKGROUND: Oral anticoagulation (OAC) therapy is associated with increased periprocedural risks after cardiac implantable electronic device (CIED) implantation. Patterns of anticoagulation management involving non-vitamin K antagonist oral anticoagulants ... Full text Link to item Cite

Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).

Conference Am J Cardiol · August 15, 2017 Non-dihydropyridine calcium channel blockers (non-DHP CCBs) possess combined P-glycoprotein and moderate CYP3A4 inhibition, which may lead to increased exposure of medications that are substrates for these metabolic pathways, such as rivaroxaban. We evalua ... Full text Link to item Cite

Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial.

Journal article Thromb Res · August 2017 BACKGROUND: The ROCKET AF study evaluated once-daily rivaroxaban versus dose-adjusted warfarin for the prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). In this analysis, we compared rivaroxaban with warfarin in patients ... Full text Link to item Cite

Updated European Heart Rhythm Association practical guide on the use of non-vitamin-K antagonist anticoagulants in patients with non-valvular atrial fibrillation: Executive summary.

Journal article Eur Heart J · July 14, 2017 In 2013, the European Heart Rhythm Association (EHRA) published a Practical Guide on the use of non-VKA oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) (Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, Sinnaeve P, Camm ... Full text Link to item Cite

Ranolazine reduces atrial fibrillatory wave frequency.

Journal article Europace · July 1, 2017 AIMS: Antiarrhythmic medications for the treatment of atrial fibrillation (AF) have limited efficacy and rare but potentially life-threatening side effects. Ranolazine is an antianginal agent that may have antiarrhythmic activity in AF. METHODS AND RESULTS ... Full text Link to item Cite

Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).

Journal article Am Heart J · July 2017 BACKGROUND: Several non-vitamin K antagonist oral anticoagulant (NOAC) alternatives to warfarin are available for stroke prevention in atrial fibrillation (AF). We aimed to describe the factors associated with selection of NOACs versus warfarin in patients ... Full text Link to item Cite

Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry.

Journal article Eur Heart J Qual Care Clin Outcomes · July 1, 2017 AIMS: The presence of cancer can complicate treatment choices for patients with atrial fibrillation (AF) increasing both the risk of thrombotic and bleeding events. METHODS AND RESULTS: Using data from Outcomes Registry for Better Informed Treatment of Atr ... Full text Open Access Link to item Cite

Relation of Risk of Stroke in Patients With Atrial Fibrillation to Body Mass Index (from Patients Treated With Rivaroxaban and Warfarin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Trial).

Journal article Am J Cardiol · June 15, 2017 We investigated stroke outcomes in normal weight (body mass index [BMI] 18.50 to 24.99 kg/m2), overweight (BMI 25.00 to 29.99 kg/m2), and obese (BMI ≥30 kg/m2) patients with atrial fibrillation treated with rivaroxaban and warfarin. We compared the inciden ... Full text Link to item Cite

Safety and Efficacy of Rivaroxaban in Patients With Cardiac Implantable Electronic Devices: Observations From the ROCKET AF Trial.

Journal article J Am Heart Assoc · June 14, 2017 BACKGROUND: Although implantation of cardiac implantable electronic devices (CIEDs) in patients receiving warfarin is well studied, limited data are available on the use of oral factor Xa inhibitors in this setting. METHODS AND RESULTS: Using data from Riv ... Full text Link to item Cite

When Less Is Not More.

Journal article J Am Coll Cardiol · June 13, 2017 Full text Link to item Cite

Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life Scores in Patients With Heart Failure (from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF]).

Journal article Am J Cardiol · June 1, 2017 The degree to which clinical outcomes are worsened in patients with atrial fibrillation (AF) with heart failure (HF) compared with those without HF is not well described. This study aimed to determine the impact of HF on clinical outcomes in patients with ... Full text Link to item Cite

Management of Major Bleeding in Patients With Atrial Fibrillation Treated With Non-Vitamin K Antagonist Oral Anticoagulants Compared With Warfarin in Clinical Practice (from Phase II of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF II]).

Journal article Am J Cardiol · May 15, 2017 Non-vitamin K antagonist oral anticoagulants (NOACs) are effective at preventing stroke in patients with atrial fibrillation (AF). However, little is known about the management of bleeding in contemporary, clinical use of NOACs. We aimed to assess the freq ... Full text Link to item Cite

Survival in Women Versus Men Following Implantation of Pacemakers, Defibrillators, and Cardiac Resynchronization Therapy Devices in a Large, Nationwide Cohort.

Journal article J Am Heart Assoc · May 10, 2017 BACKGROUND: Whether outcomes differ between sexes following treatment with pacemakers (PM), implantable cardioverter defibrillators, and cardiac resynchronization therapy (CRT) devices is unclear. METHODS AND RESULTS: Consecutive US patients with newly imp ... Full text Link to item Cite

Screening for Atrial Fibrillation: A Report of the AF-SCREEN International Collaboration.

Journal article Circulation · May 9, 2017 Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these strokes by instituting appropriate anticoagulation. The AF-SCR ... Full text Link to item Cite

Long-term outcomes in leadless Micra transcatheter pacemakers with elevated thresholds at implantation: Results from the Micra Transcatheter Pacing System Global Clinical Trial.

Journal article Heart Rhythm · May 2017 BACKGROUND: Device repositioning during Micra leadless pacemaker implantation may be required to achieve optimal pacing thresholds. OBJECTIVE: The purpose of this study was to describe the natural history of acute elevated Micra vs traditional transvenous ... Full text Link to item Cite

Long-term electrocardiographic safety monitoring in clinical drug development: A report from the Cardiac Safety Research Consortium.

Journal article Am Heart J · May 2017 This white paper, prepared by members of the Cardiac Safety Research Consortium (CSRC), discusses important issues regarding scientific and clinical aspects of long-term electrocardiographic safety monitoring during clinical drug development. To promote mu ... Full text Link to item Cite

Absence of Oral Anticoagulation and Subsequent Outcomes Among Outpatients with Atrial Fibrillation.

Journal article Am J Med · April 2017 BACKGROUND: Prior studies have shown a treatment gap in oral anticoagulation (OAC) use among patients with atrial fibrillation yet have incompletely characterized factors associated with failure to treat and subsequent outcomes in contemporary practice. ME ... Full text Link to item Cite

Autonomic Modulation for the Treatment of Ventricular Arrhythmias: Therapeutic Use of Percutaneous Stellate Ganglion Blocks.

Journal article J Cardiovasc Electrophysiol · April 2017 Ventricular tachycardia (VT), ventricular fibrillation (VF), and electrical storm are commonly encountered emergency conditions in cardiac and surgical intensive care units. In most cases, recurrent ventricular arrhythmias or electrical storm are associate ... Full text Link to item Cite

Use of Preprocedural MDCT for Cardiac Implantable Electric Device Lead Extraction: Frequency of Findings That Change Management.

Journal article AJR Am J Roentgenol · April 2017 OBJECTIVE: Five percent of cardiac implantable electric devices (CIEDs) are removed each year. Percutaneous extraction is preferred but can be complicated if the leads adhere to the vasculature or perforate. The goal of this study is to assess the frequenc ... Full text Link to item Cite

Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon?

Journal article Pacing Clin Electrophysiol · April 2017 BACKGROUND: Symptomatic sinus node dysfunction (SND) consists of a variety of manifestations, including tachycardia-bradycardia syndrome. Atrial fibrillation (AF) is commonly associated with SND, which complicates the management of both conditions. This pa ... Full text Link to item Cite

Left atrial appendage occlusion: rationale, evidence, devices, and patient selection.

Journal article Eur Heart J · March 21, 2017 Atrial fibrillation (AF) is a worldwide epidemic associated with significant morbidity and mortality, often due to disabling or fatal thromboembolic stroke. Oral anticoagulation is highly effective at preventing ischaemic stroke and improving all-cause sur ... Full text Link to item Cite

Management of Patients on Non-Vitamin K Antagonist Oral Anticoagulants in the Acute Care and Periprocedural Setting: A Scientific Statement From the American Heart Association.

Journal article Circulation · March 7, 2017 Non-vitamin K oral anticoagulants (NOACs) are now widely used as alternatives to warfarin for stroke prevention in atrial fibrillation and management of venous thromboembolism. In clinical practice, there is still widespread uncertainty on how to manage pa ... Full text Link to item Cite

Quality of Evidence Underlying the American Heart Association/American College of Cardiology/Heart Rhythm Society Guidelines on the Management of Atrial Fibrillation.

Journal article JAMA Cardiol · March 1, 2017 IMPORTANCE: The joint American College of Cardiology (ACC), American Heart Association (AHA), and Heart Rhythm Society (HRS) guidelines on the management of atrial fibrillation (AF) are used extensively to guide patient care. OBJECTIVE: To describe the evi ... Full text Link to item Cite

Cardioversion and subsequent quality of life and natural history of atrial fibrillation.

Journal article Am Heart J · March 2017 UNLABELLED: Cardioversion is a class I procedure for patients with symptomatic atrial fibrillation (AF) pursuing rhythm control. There are few contemporary reports on quality of life and outcomes after cardioversion. METHODS: Using the nationwide prospecti ... Full text Link to item Cite

Safety and Efficacy of Exercise Training in Patients With an Implantable Cardioverter-Defibrillator: A Meta-Analysis.

Journal article JACC Clin Electrophysiol · February 2017 OBJECTIVES: In this study, the authors performed a meta-analysis of currently available comparative prospective studies to assess the efficacy and safety of exercise training in heart failure (HF) patients with implantable cardioverter-defibrillators (ICD) ... Full text Link to item Cite

Safety and Clinical Outcomes of Catheter Ablation of Atrial Fibrillation in Patients With Chronic Kidney Disease.

Journal article J Cardiovasc Electrophysiol · January 2017 INTRODUCTION: Data regarding catheter ablation of atrial fibrillation (AF) in patients with chronic kidney disease (CKD) is limited. We therefore assessed the association of CKD with common safety and clinical outcomes in a nationwide sample of ablation re ... Full text Link to item Cite

Predictors and Prognostic Implications of Incident Heart Failure in Patients With Prevalent Atrial Fibrillation.

Journal article JACC Heart Fail · January 2017 OBJECTIVES: The purpose of this study was to determine the significant clinical predictors of incident heart failure (HF) and its prognostic effect on long-term outcomes among community-based patients with established atrial fibrillation (AF). BACKGROUND: ... Full text Link to item Cite

Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation.

Journal article Europace · January 2017 AIMS: Catheter ablation is the most efficacious rhythm control therapy in atrial fibrillation (AF) patients. There is growing evidence that catheter ablation procedures are best performed during continuous oral anticoagulation, but outcomes are variable de ... Full text Link to item Cite

Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes: The ORBIT-AF II Registry.

Journal article J Am Coll Cardiol · December 20, 2016 BACKGROUND: Although non-vitamin K antagonist oral anticoagulants (NOACs) do not require frequent laboratory monitoring, each compound requires dose adjustments on the basis of certain clinical criteria. OBJECTIVES: This study assessed the frequency of off ... Full text Link to item Cite

Patient factors associated with quality of life in atrial fibrillation.

Journal article Am Heart J · December 2016 BACKGROUND: As treatment options for atrial fibrillation (AF) increase, more attention is focused on patients' experiences and quality of life (QoL). However, little is known about the factors associated with these outcomes. METHODS: The Atrial Fibrillatio ... Full text Link to item Cite

Impact of remote monitoring on clinical events and associated health care utilization: A nationwide assessment.

Journal article Heart Rhythm · December 2016 BACKGROUND: Remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) improves patient survival. However, whether RM reduces health care utilization is unknown. OBJECTIVE: The purpose of this study was to determine whether RM was associated ... Full text Link to item Cite

Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study.

Journal article J Am Heart Assoc · November 19, 2016 BACKGROUND: We examined all-cause mortality and long-term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (AF). METHODS AND RESULTS: Using Danish nationwid ... Full text Open Access Link to item Cite

How well does physician risk assessment predict stroke and bleeding in atrial fibrillation? Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Am Heart J · November 2016 BACKGROUND: Assessments of stroke and bleeding risks are essential to selecting oral anticoagulation in patients with atrial fibrillation (AF). We aimed to assess outcomes according to physician assessed risk, with comparison to empirical risk scores. METH ... Full text Link to item Cite

Gender Differences in Clinical Outcomes after Catheter Ablation of Atrial Fibrillation.

Journal article JACC Clin Electrophysiol · November 2016 OBJECTIVE: To explore gender differences in real-world outcomes after catheter ablation of atrial fibrillation (AF). BACKGROUND: Compared to men, women with AF have greater thromboembolic risk and tend to be more symptomatic. Catheter ablation is generally ... Full text Link to item Cite

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants After Cardioversion for Nonvalvular Atrial Fibrillation.

Journal article Am J Med · October 2016 BACKGROUND: Non-vitamin K oral anticoagulants (NOACs) are proven alternatives to vitamin K antagonists (VKAs) for the prevention of thromboembolism in patients with nonvalvular atrial fibrillation. However, there are few data on the efficacy and safety of ... Full text Link to item Cite

Randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent onset atrial fibrillation or flutter to normal sinus rhythm: RESTORE SR.

Journal article Heart Rhythm · September 2016 BACKGROUND: Vanoxerine is an oral, 1,4-dialkylpiperazine derivative antiarrhythmic drug being evaluated for pharmacological cardioversion of atrial fibrillation (AF). OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of vanoxerin ... Full text Link to item Cite

Use of concomitant aspirin in patients with atrial fibrillation: Findings from the ROCKET AF trial.

Journal article Am Heart J · September 2016 BACKGROUND: We aimed to investigate the relationship between aspirin use and clinical outcomes in patients enrolled in Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in ... Full text Link to item Cite

Dual Antiplatelet Therapy and Outcomes in Patients With Atrial Fibrillation and Acute Coronary Syndromes Managed Medically Without Revascularization: Insights From the TRILOGY ACS Trial.

Journal article Clin Cardiol · September 2016 Associations between atrial fibrillation (AF), outcomes, and response to antiplatelet therapies in patients with acute coronary syndrome (ACS) managed medically without revascularization remain uncertain. We examined these associations for medically manage ... Full text Link to item Cite

Use of Dual Antiplatelet Therapy and Patient Outcomes in Those Undergoing Percutaneous Coronary Intervention: The ROCKET AF Trial.

Journal article JACC Cardiovasc Interv · August 22, 2016 OBJECTIVES: The authors assessed the use of dual antiplatelet therapy (DAPT) and outcomes in patients undergoing percutaneous coronary intervention (PCI) during the ROCKET AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K ... Full text Link to item Cite

Rhythm control in atrial fibrillation.

Journal article Lancet · August 20, 2016 Many patients with atrial fibrillation have substantial symptoms despite ventricular rate control and require restoration of sinus rhythm to improve their quality of life. Acute restoration (ie, cardioversion) and maintenance of sinus rhythm in patients wi ... Full text Link to item Cite

Improved survival in patients enrolled promptly into remote monitoring following cardiac implantable electronic device implantation.

Journal article J Interv Card Electrophysiol · August 2016 PURPOSE: Guidelines advocate remote monitoring (RM) in patients with a cardiac implantable electronic device (CIED). However, it is not known when RM should be initiated. We hypothesized that prompt initiation of RM (within 91 days of implant) is associate ... Full text Link to item Cite

Remote monitoring of cardiac implantable electronic devices (CIED).

Journal article Trends Cardiovasc Med · August 2016 With increasing indications and access to cardiac implantable electronic devices (CIEDs) worldwide, the number of patients needing CIED follow-up continues to rise. In parallel, the technology available for managing these devices has advanced considerably. ... Full text Link to item Cite

Hospitalizations in patients with atrial fibrillation: an analysis from ROCKET AF.

Journal article Europace · August 2016 AIMS: The high costs associated with treatment for atrial fibrillation (AF) are primarily due to hospital care, but there are limited data to understand the reasons for and predictors of hospitalization in patients with AF. METHODS AND RESULTS: The ROCKET ... Full text Link to item Cite

Blood pressure control and stroke or bleeding risk in anticoagulated patients with atrial fibrillation: Results from the ROCKET AF Trial.

Journal article Am Heart J · August 2016 BACKGROUND: We conducted a retrospective analysis examining the association between systolic blood pressure (SBP) or hypertension bracket and stroke risk in patients with atrial fibrillation (AF). METHODS: The study included 14,256 anticoagulated patients ... Full text Link to item Cite

On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF.

Journal article Circulation · July 5, 2016 BACKGROUND: Despite rapid clinical adoption of novel anticoagulants, it is unknown whether outcomes differ among patients with worsening renal function (WRF) taking these new drugs compared with warfarin. We aimed to determine whether the primary efficacy ... Full text Link to item Cite

Native valve disease in patients with non-valvular atrial fibrillation on warfarin or rivaroxaban.

Journal article Heart · July 1, 2016 OBJECTIVE: To compare the characteristics and outcomes of patients with atrial fibrillation (AF) and aortic stenosis (AS) with patients with AF with mitral regurgitation (MR) or aortic regurgitation (AR) and patients without significant valve disease (no S ... Full text Link to item Cite

Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF.

Journal article J Am Coll Cardiol · June 21, 2016 Nonvitamin K-dependent oral anticoagulant agents (NOACs) are currently recommended for patients with atrial fibrillation at risk for stroke. As a group, NOACs significantly reduce stroke, intracranial hemorrhage, and mortality, with lower to similar major ... Full text Link to item Cite

Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease.

Journal article Am J Med · June 2016 BACKGROUND: The role of triple antithrombotic therapy vs dual antithrombotic therapy in patients with both atrial fibrillation and coronary artery disease remains unclear. This study explores the differences in treatment practices and outcomes between trip ... Full text Link to item Cite

Extraction of chronically implanted coronary sinus leads active fixation vs passive fixation leads.

Journal article Heart Rhythm · June 2016 BACKGROUND: The Medtronic model 4195 (StarFix) left ventricular lead is an active fixation lead that provides additional support within the coronary sinus (CS) via deployable lobes. While this lead has been shown to have excellent stability within the CS, ... Full text Link to item Cite

Comparative Effectiveness of Cardiac Resynchronization Therapy Among Patients With Heart Failure and Atrial Fibrillation: Findings From the National Cardiovascular Data Registry's Implantable Cardioverter-Defibrillator Registry.

Journal article Circ Heart Fail · June 2016 BACKGROUND: Atrial fibrillation is common in patients with heart failure, but outcomes of patients with both conditions who receive cardiac resynchronization therapy with defibrillator (CRT-D) compared with an implantable cardioverter-defibrillator (ICD) a ... Full text Link to item Cite

Differences in Clinical and Functional Outcomes of Atrial Fibrillation in Women and Men: Two-Year Results From the ORBIT-AF Registry.

Journal article JAMA Cardiol · June 1, 2016 IMPORTANCE: Despite the frequency of atrial fibrillation (AF) in clinical practice, relatively little is known about sex differences in symptoms and quality of life and how they may affect treatment and outcomes. OBJECTIVE: To determine whether symptoms, q ... Full text Link to item Cite

Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.

Journal article JACC Clin Electrophysiol · June 2016 OBJECTIVES: This study sought to determine the association between body mass index (BMI) and clinical outcomes among patients with prevalent atrial fibrillation (AF). BACKGROUND: Higher BMI is an independent risk factor for incident AF. However, its impact ... Full text Link to item Cite

Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry.

Journal article J Am Heart Assoc · May 4, 2016 BACKGROUND: Whereas insurance status has been previously associated with care patterns, little is currently known about the association between Medicaid insurance and the clinical characteristics, treatment, or outcomes of patients with atrial fibrillation ... Full text Open Access Link to item Cite

Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article Am Heart J · May 2016 BACKGROUND: We addressed whether patients with a family history of atrial fibrillation (AF) were diagnosed as having AF earlier in life, were more symptomatic, and had worse outcomes compared with those without a family history of AF. METHODS: Using the OR ... Full text Link to item Cite

Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark.

Journal article Europace · May 2016 AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients. METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identifi ... Full text Link to item Cite

Racial/ethnic differences in atrial fibrillation symptoms, treatment patterns, and outcomes: Insights from Outcomes Registry for Better Informed Treatment for Atrial Fibrillation Registry.

Journal article Am Heart J · April 2016 BACKGROUND: Significant racial/ethnic differences exist in the incidence of atrial fibrillation (AF). However, less is known about racial/ethnic differences in quality of life (QoL), treatment, and outcomes associated with AF. METHODS: Using data from the ... Full text Link to item Cite

Rhythm Control Versus Rate Control and Clinical Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.

Journal article JACC Clin Electrophysiol · April 2016 OBJECTIVES: The study sought to evaluate clinical outcomes in clinical practice with rhythm control versus rate control strategy for management of atrial fibrillation (AF). BACKGROUND: Randomized trials have not demonstrated significant differences in stro ... Full text Link to item Cite

Sudden Cardiac Death After Non-ST-Segment Elevation Acute Coronary Syndrome.

Journal article JAMA Cardiol · April 1, 2016 IMPORTANCE: In the current therapeutic era, the risk for sudden cardiac death (SCD) after non-ST-segment elevation acute coronary syndrome (NSTE ACS) has not been characterized completely. OBJECTIVE: To determine the cumulative incidence of SCD during long ... Full text Link to item Cite

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF.

Journal article J Am Heart Assoc · March 8, 2016 BACKGROUND: Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. METHODS AND RESULTS: In the Rivaroxaban Once Daily Oral Direct Factor Xa I ... Full text Link to item Cite

Why develop antidotes and reversal agents for non-vitamin K oral anticoagulants?

Journal article J Thromb Thrombolysis · February 2016 Over the past several years, non-vitamin K oral anticoagulants (NOACs) have been introduced into clinical practice for the treatment of venous thromboembolism and prevention of stroke in patients with nonvalvular atrial fibrillation. Clinical trials have s ... Full text Link to item Cite

Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.

Journal article Clin Cardiol · February 2016 BACKGROUND: Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been well described. HYPOTHESIS: Patien ... Full text Open Access Link to item Cite

Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.

Journal article Circulation · January 26, 2016 BACKGROUND: Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS: We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and ... Full text Link to item Cite

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference.

Journal article Europace · January 2016 At least 30 million people worldwide carry a diagnosis of atrial fibrillation (AF), and many more suffer from undiagnosed, subclinical, or 'silent' AF. Atrial fibrillation-related cardiovascular mortality and morbidity, including cardiovascular deaths, hea ... Full text Link to item Cite

High-degree atrioventricular block, asystole, and electro-mechanical dissociation complicating non-ST-segment elevation myocardial infarction.

Journal article Am Heart J · January 2016 UNLABELLED: Non-ST-segment myocardial infarction (NSTEMI) can be complicated by high-degree atrioventricular (AV) block, asystole, or electromechanical dissociation (EMD), but these events are not well characterized in the contemporary era. This analysis a ... Full text Link to item Cite

The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.

Journal article Eur Heart J · December 7, 2015 BACKGROUND: Therapeutic decisions in atrial fibrillation (AF) are often influenced by assessment of bleeding risk. However, existing bleeding risk scores have limitations. OBJECTIVES: We sought to develop and validate a novel bleeding risk score using rout ... Full text Open Access Link to item Cite

Atrial fibrillation in heart failure: what should we do?

Journal article Eur Heart J · December 7, 2015 Heart failure (HF) and atrial fibrillation (AF) are two conditions that are likely to dominate the next 50 years of cardiovascular (CV) care. Both are increasingly prevalent and associated with high morbidity, mortality, and healthcare cost. They are close ... Full text Link to item Cite

The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation

Journal article European heart journal · December 7, 2015 BACKGROUND: Therapeutic decisions in atrial fibrillation (AF) are often influenced by assessment of bleeding risk. However, existing bleeding risk scores have limitations. ... Full text Cite

Atrioventricular and ventricular-to-ventricular programming in patients with cardiac resynchronization therapy: results from ALTITUDE.

Journal article J Interv Card Electrophysiol · December 2015 PURPOSE: Cardiac resynchronization therapy (CRT) improves outcomes in patients with heart failure, yet response rates are variable. We sought to determine whether physician-specified CRT programming was associated with improved outcomes. METHODS: Using dat ... Full text Link to item Cite

Gastrointestinal Bleeding in Patients With Atrial Fibrillation Treated With Rivaroxaban or Warfarin: ROCKET AF Trial.

Journal article J Am Coll Cardiol · December 1, 2015 BACKGROUND: Gastrointestinal (GI) bleeding is a common complication of oral anticoagulation. OBJECTIVES: This study evaluated GI bleeding in patients who received at least 1 dose of the study drug in the on-treatment arm of the ROCKET AF (Rivaroxaban Once- ... Full text Link to item Cite

Calcified Pipes: You Better Call the Electrician Too.

Journal article Circ Cardiovasc Imaging · December 2015 Full text Link to item Cite

Patterns of Anticoagulation Use and Cardioembolic Risk After Catheter Ablation for Atrial Fibrillation.

Journal article J Am Heart Assoc · November 5, 2015 BACKGROUND: There is significant practice variation in oral anticoagulation (OAC) use following catheter ablation for atrial fibrillation. It is not clear whether the risk of cardioembolism increases after discontinuation of OAC following catheter ablation ... Full text Link to item Cite

Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery.

Journal article Anesth Analg · October 2015 BACKGROUND: Hypomagnesemia has been associated with an increased risk of postoperative atrial fibrillation (POAF). Although previous studies have suggested a beneficial effect of magnesium (Mg) therapy, almost all of these are limited by small sample size ... Full text Link to item Cite

Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial fibrillation: the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF Trial).

Journal article Am Heart J · October 2015 BACKGROUND: The prevalence of both atrial fibrillation (AF) and diabetes mellitus (DM) are rising, and these conditions often occur together. Also, DM is an independent risk factor for stroke in patients with AF. We aimed to examine the safety and efficacy ... Full text Link to item Cite

Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF).

Journal article J Am Heart Assoc · September 14, 2015 BACKGROUND: Most patients with atrial fibrillation (AF) require rate control; however, the optimal target heart rate remains under debate. We aimed to assess rate control and subsequent outcomes among patients with permanent AF. METHODS AND RESULTS: We stu ... Full text Open Access Link to item Cite

Contraindications to anticoagulation therapy and eligibility for novel anticoagulants in older patients with atrial fibrillation.

Journal article Cardiovasc Ther · August 2015 AIMS: Oral anticoagulation therapy prevents stroke and improves survival in patients with atrial fibrillation, but the therapy is underutilized. We sought to identify the prevalence of contraindications for oral anticoagulation and the proportion of patien ... Full text Link to item Cite

Association Between Atrial Fibrillation Symptoms, Quality of Life, and Patient Outcomes: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Circ Cardiovasc Qual Outcomes · July 2015 BACKGROUND: Instruments to assess symptom burden and quality of life among patients with atrial fibrillation (AF) have not been well evaluated in community practice or associated with patient outcomes. METHODS AND RESULTS: Using data from 10 087 AF patient ... Full text Link to item Cite

Patients' time in therapeutic range on warfarin among US patients with atrial fibrillation: Results from ORBIT-AF registry.

Journal article Am Heart J · July 2015 BACKGROUND: Time in therapeutic range (TTR) of international normalized ratio (INR) of 2.0 to 3.0 is important for the safety and effectiveness of warfarin anticoagulation. There are few data on TTR among patients with atrial fibrillation (AF) in community ... Full text Link to item Cite

Digoxin Use and Subsequent Outcomes Among Patients in a Contemporary Atrial Fibrillation Cohort.

Journal article J Am Coll Cardiol · June 30, 2015 BACKGROUND: Although digoxin has long been used to treat atrial fibrillation (AF) and heart failure (HF), its safety remains controversial. OBJECTIVES: This study sought to describe digoxin use over time in patients with AF who were stratified by the prese ... Full text Link to item Cite

The Relationship Between Level of Adherence to Automatic Wireless Remote Monitoring and Survival in Pacemaker and Defibrillator Patients.

Journal article J Am Coll Cardiol · June 23, 2015 BACKGROUND: Remote monitoring (RM) technology embedded within cardiac rhythm devices permits continuous monitoring, which may result in improved patient outcomes. OBJECTIVES: This study used "big data" to assess whether RM is associated with improved survi ... Full text Link to item Cite

Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).

Journal article Lancet · June 13, 2015 BACKGROUND: Digoxin is a widely used drug for ventricular rate control in patients with atrial fibrillation (AF), despite a scarcity of randomised trial data. We studied the use and outcomes of digoxin in patients in the Rivaroxaban Once Daily Oral Direct ... Full text Link to item Cite

Localization of pacing and defibrillator leads using standard x-ray views is frequently inaccurate and is not reproducible.

Journal article J Interv Card Electrophysiol · June 2015 PURPOSE: While the accuracy of roentography for evaluation of lead tip position compared with three-dimensional imaging techniques has been well described, there remains considerable variability in the interpretation of the reproducibility of standard x-ra ... Full text Link to item Cite

Heart rate is associated with progression of atrial fibrillation, independent of rhythm.

Journal article Heart · June 2015 OBJECTIVE: Atrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well described. METHODS: Using the Outcomes Registry for Better Informed ... Full text Open Access Link to item Cite

Geographic variation in the use of catheter ablation for atrial fibrillation among Medicare beneficiaries.

Journal article Am Heart J · June 2015 BACKGROUND: Catheter ablation for atrial fibrillation is used increasingly in older patients, yet the risks and benefits are not completely understood. With such uncertainty, local medical opinion may influence catheter ablation use. METHODS: In a 100% sam ... Full text Link to item Cite

Cable externalization and electrical failure of the Riata family of implantable cardioverter-defibrillator leads: A systematic review and meta-analysis.

Journal article Heart Rhythm · June 2015 BACKGROUND: The Riata class of defibrillator leads were placed under US Food and Drug Association (FDA) advisory as of November 2011 because of high rates of cable externalization (CE) and electrical failure (EF). The overall rates of these complications r ... Full text Open Access Link to item Cite

Bucindolol hydrochloride in atrial fibrillation and concomitant heart failure.

Journal article Expert Rev Cardiovasc Ther · June 2015 Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and it increases the risk of thromboembolic stroke and death. AF is common in patients with heart failure and reduced ejection fraction (HFrEF), affecting between 30 and 40% of patients with ... Full text Link to item Cite

Catheter Ablation of Atrial Fibrillation in U.S. Community Practice--Results From Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article J Am Heart Assoc · May 21, 2015 BACKGROUND: The characteristics of patients undergoing atrial fibrillation (AF) ablation and subsequent outcomes in community practice are not well described. METHODS AND RESULTS: Using the Outcomes Registry for Better Informed Treatment of Atrial Fibrilla ... Full text Open Access Link to item Cite

Outcomes after nonemergent electrical cardioversion for atrial arrhythmias.

Journal article Am J Cardiol · May 15, 2015 Electrical cardioversion (ECV) is recommended for rhythm control in patients with atrial arrhythmia; yet, ECV use and outcomes in contemporary practice are unknown. We reviewed all nonemergent ECVs for atrial arrhythmias at a tertiary care center (2010 to ... Full text Link to item Cite

Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation-Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Am Heart J · May 2015 BACKGROUND: Obstructive sleep apnea (OSA) is common in patients with atrial fibrillation (AF). Little is known about the impact of OSA on AF treatment and long-term outcomes. We studied whether patients with OSA have a greater likelihood of progressing to ... Full text Link to item Cite

Comparisons of hospitalization rates among younger atrial fibrillation patients receiving different antiarrhythmic drugs.

Journal article Circ Cardiovasc Qual Outcomes · May 2015 BACKGROUND: Antiarrhythmic drugs (AADs) are used to reduce the frequency, severity, and duration of atrial fibrillation (AF) events, which should reduce hospitalizations; however, little is known about the associations between different AADs and hospitaliz ... Full text Link to item Cite

Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial.

Journal article J Am Heart Assoc · March 3, 2015 BACKGROUND: In the ROCKET AF (Rivaroxaban-Once-daily, oral, direct Factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) trial, marked regional differences in control of warfarin anticoa ... Full text Link to item Cite

Feedback to providers improves evidence-based implantable cardioverter-defibrillator programming and reduces shocks.

Journal article Heart Rhythm · March 2015 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are associated with increased anxiety, health care utilization, and potentially mortality. OBJECTIVE: The purpose of the Shock-Less Study was to determine if providing feedback reports to phys ... Full text Link to item Cite

Use and outcomes associated with bridging during anticoagulation interruptions in patients with atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Circulation · February 3, 2015 BACKGROUND: Temporary interruption of oral anticoagulation for procedures is often required, and some propose using bridging anticoagulation. However, the use and outcomes of bridging during oral anticoagulation interruptions in clinical practice are unkno ... Full text Open Access Link to item Cite

Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial.

Journal article Eur Heart J · February 1, 2015 AIM: Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation. METHODS AND RE ... Full text Link to item Cite

Optimal management of Riata leads with no known electrical abnormalities or externalization: a decision analysis.

Journal article J Cardiovasc Electrophysiol · February 2015 INTRODUCTION: Riata and Riata ST implantable cardioverter-defibrillator (ICD) leads (St. Jude Medical, Sylmar, CA, USA) can develop conductor cable externalization and/or electrical failure. Optimal management of these leads remains unknown. METHODS AND RE ... Full text Open Access Link to item Cite

Antiarrhythmic drug use in patients <65 years with atrial fibrillation and without structural heart disease.

Journal article Am J Cardiol · February 1, 2015 Little is known in clinical practice about antiarrhythmic drug (AAD) use in patients with atrial fibrillation (AF) (particularly younger ones) who do not have structural heart disease. Using the MarketScan database, we identified patients <65 years without ... Full text Link to item Cite

Predictors and progression of aortic stenosis in patients with preserved left ventricular ejection fraction.

Journal article Am J Cardiol · January 1, 2015 We aimed to characterize the hemodynamic progression of aortic stenosis (AS) in a contemporary unselected cohort of patients with preserved left ventricular ejection fraction. Current guidelines recommend echocardiographic surveillance of hemodynamic progr ... Full text Link to item Cite

Exercise training and pacing status in patients with heart failure: results from HF-ACTION.

Journal article J Card Fail · January 2015 BACKGROUND: We sought to determine if outcomes with exercise training in heart failure (HF) vary according to ventricular pacing type. METHODS AND RESULTS: Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized ... Full text Link to item Cite

Accuracy and validation of an automated electronic algorithm to identify patients with atrial fibrillation at risk for stroke.

Journal article Am Heart J · January 2015 BACKGROUND: There is no universally accepted algorithm for identifying atrial fibrillation (AF) patients and stroke risk using electronic data for use in performance measures. METHODS: Patients with AF seen in clinic were identified based on International ... Full text Link to item Cite

Heart rate is associated with progression of atrial fibrillation, independent of rhythm

Journal article Heart · 2015 © 2015 BMJ Publishing Group Ltd & British Cardiovascular Society.Objective Atrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well ... Full text Cite

Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial.

Journal article Eur Heart J · December 14, 2014 AIMS: We investigated clinical characteristics and outcomes of patients with significant valvular disease (SVD) in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in ... Full text Link to item Cite

Novel mechanism of premature battery failure due to lithium cluster formation in implantable cardioverter-defibrillators.

Journal article Heart Rhythm · December 2014 BACKGROUND: Battery failure is an uncommon complication of implantable cardioverter-defibrillators (ICDs), but unanticipated battery depletion can have life-threatening consequences. OBJECTIVE: The purpose of this study was to describe the prevalence of a ... Full text Link to item Cite

Periprocedural imaging and outcomes after catheter ablation of atrial fibrillation.

Journal article Heart · December 2014 OBJECTIVE: Catheter ablation of atrial fibrillation (AF) has become an increasingly safe and effective therapy. This has been partly attributed to the use of adjunctive imaging modalities. We aimed to describe the use and associated outcomes of periprocedu ... Full text Link to item Cite

Clinical effectiveness of cardiac resynchronization therapy versus medical therapy alone among patients with heart failure: analysis of the ICD Registry and ADHERE.

Conference Circ Heart Fail · November 2014 BACKGROUND: Cardiac resynchronization therapy with defibrillator (CRT-D) reduces morbidity and mortality among selected patients with heart failure in clinical trials. The effectiveness of this therapy in clinical practice has not been well studied. METHOD ... Full text Link to item Cite

Cardiac implantable electronic device removal in patients with left ventricular assist device associated infections.

Journal article J Cardiovasc Electrophysiol · November 2014 INTRODUCTION: Heart failure patients with left ventricular assist devices (LVADs) are at risk for infection. Cardiac implantable electronic devices (CIEDs) are commonly present in these patients. The course of infections in patients with an LVAD and a CIED ... Full text Link to item Cite

Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Am Heart J · October 2014 BACKGROUND: Warfarin reduces thromboembolic risks in atrial fibrillation (AF), but therapeutic durability remains a concern. METHODS: We used clinical data from ORBIT-AF, a nationwide outpatient AF registry conducted at 176 sites with follow-up data at 6 a ... Full text Link to item Cite

Preprocedural ECG-gated computed tomography for prevention of complications during lead extraction.

Journal article Pacing Clin Electrophysiol · October 2014 BACKGROUND: Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. METHODS: To describe the use and feasibility of computed tomography scanning for preprocedural planning of ... Full text Link to item Cite

Use of antiarrhythmic drug therapy and clinical outcomes in older patients with concomitant atrial fibrillation and coronary artery disease.

Journal article Europace · September 2014 AIMS: Atrial fibrillation (AF) and coronary artery disease (CAD) are common in older patients. We aimed to describe the use of antiarrhythmic drug (AAD) therapy and clinical outcomes in these patients. METHODS AND RESULTS: We analysed AAD therapy and outco ... Full text Link to item Cite

Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease.

Journal article Am J Cardiol · September 1, 2014 Sotalol is a commonly prescribed antiarrhythmic drug (AAD) used for maintaining sinus rhythm in patients with atrial fibrillation (AF). Although randomized studies have found that sotalol can significantly delay time to AF recurrence, its association with ... Full text Link to item Cite

Associations between anticoagulation therapy and risks of mortality and readmission among patients with heart failure and atrial fibrillation.

Journal article Circ Cardiovasc Qual Outcomes · September 2014 BACKGROUND: Patients with heart failure and atrial fibrillation are at higher risk of thromboembolic events than patients with heart failure alone. Yet, the use of anticoagulation therapy varies in clinical practice, especially among older patients, for wh ... Full text Link to item Cite

Get With The Guidelines AFIB: novel quality improvement registry for hospitalized patients with atrial fibrillation.

Journal article Circ Cardiovasc Qual Outcomes · September 2014 BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is a cause of stroke, heart failure, and death. Guideline-based treatment can improve outcomes in AF. Unfortunately, adherence to these guidelines is low. Get With The ... Full text Link to item Cite

Rhythm control in heart failure patients with atrial fibrillation: contemporary challenges including the role of ablation.

Journal article J Am Coll Cardiol · August 19, 2014 Because nonpharmacological interventions likely alter the risks and benefits associated with rhythm control, this paper reviews the role of current rhythm control strategies in atrial fibrillation. This report also focuses on the specific limitations of ph ... Full text Link to item Cite

Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II: rationale and design of the ORBIT-AF II registry.

Journal article Am Heart J · August 2014 BACKGROUND: Recent clinical trials have demonstrated the safety and efficacy of several non-vitamin K oral anticoagulants (NOACs) for the treatment of atrial fibrillation (AF). However, there are limited data on their use and outcomes in routine clinical p ... Full text Link to item Cite

Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial.

Journal article Eur Heart J · July 21, 2014 AIMS: There are no data regarding management and outcomes of major bleeding events in patients treated with oral factor Xa inhibitors. METHODS AND RESULTS: Using data from ROCKET AF, we analysed the management and outcomes of major bleeding overall and acc ... Full text Link to item Cite

Cost analysis of periprocedural imaging in patients undergoing catheter ablation for atrial fibrillation.

Journal article Am J Cardiol · July 15, 2014 Cardiovascular imaging is an important part of procedural planning and safety for catheter ablation of atrial fibrillation (AF). However, the costs of imaging surrounding catheter ablation of AF have not been described. Medicare fee-for-service data were u ... Full text Link to item Cite

Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).

Journal article Circulation · July 8, 2014 BACKGROUND: Nonvalvular atrial fibrillation is common in elderly patients, who face an elevated risk of stroke but difficulty sustaining warfarin treatment. The oral factor Xa inhibitor rivaroxaban was noninferior to warfarin in the Rivaroxaban Once Daily, ... Full text Link to item Cite

Use and outcomes of antiarrhythmic therapy in patients with atrial fibrillation receiving oral anticoagulation: results from the ROCKET AF trial.

Journal article Heart Rhythm · June 2014 BACKGROUND: Antiarrhythmic drugs (AADs) and anticoagulation are mainstays of atrial fibrillation (AF) treatment. OBJECTIVE: To study the use and outcomes of AAD therapy in anticoagulated patients with AF. METHODS: Patients in the Rivaroxaban Once Daily Ora ... Full text Link to item Cite

Lack of concordance between empirical scores and physician assessments of stroke and bleeding risk in atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article Circulation · May 20, 2014 BACKGROUND: Physicians treating patients with atrial fibrillation (AF) must weigh the benefits of anticoagulation in preventing stroke versus the risk of bleeding. Although empirical models have been developed to predict such risks, the degree to which the ... Full text Link to item Cite

Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF).

Journal article Circulation · May 6, 2014 BACKGROUND: During long-term anticoagulation in atrial fibrillation, temporary interruptions (TIs) of therapy are common, but the relationship between patient outcomes and TIs has not been well studied. We sought to determine reasons for TI, the characteri ... Full text Link to item Cite

Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study.

Journal article Ann Intern Med · May 6, 2014 BACKGROUND: Trials comparing implantable cardioverter-defibrillator (ICD) therapy with cardiac resynchronization therapy with a defibrillator (CRT-D) are limited to selected patients treated at centers with extensive experience. OBJECTIVE: To compare outco ... Full text Link to item Cite

Drivers of hospitalization for patients with atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Am Heart J · May 2014 BACKGROUND: Atrial fibrillation (AF) is the most common cardiac dysrhythmia and contributes significantly to health care expenditures. We sought to assess the frequency and predictors of hospitalization in patients with AF. METHODS: The ORBIT-AF registry i ... Full text Link to item Cite

Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation.

Journal article Stroke · May 2014 BACKGROUND AND PURPOSE: Intracranial hemorrhage (ICH) is a life-threatening complication of anticoagulation. METHODS: We investigated the rate, outcomes, and predictors of ICH in 14 264 patients with atrial fibrillation from Rivaroxaban Once Daily, Oral, D ... Full text Link to item Cite

Relationship between time in therapeutic range and comparative treatment effect of rivaroxaban and warfarin: results from the ROCKET AF trial.

Journal article J Am Heart Assoc · April 22, 2014 BACKGROUND: Time in therapeutic range (TTR) is a standard quality measure of the use of warfarin. We assessed the relative effects of rivaroxaban versus warfarin at the level of trial center TTR (cTTR) since such analysis preserves randomized comparisons. ... Full text Link to item Cite

Anticoagulation in atrial fibrillation.

Journal article BMJ · April 14, 2014 Atrial fibrillation increases the risk of stroke, which is a leading cause of death and disability worldwide. The use of oral anticoagulation in patients with atrial fibrillation at moderate or high risk of stroke, estimated by established criteria, improv ... Full text Link to item Cite

Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article Am Heart J · April 2014 BACKGROUND: Oral anticoagulation (OAC) therapy reduces the risk of thromboembolic events associated with atrial fibrillation (AF), yet a substantial proportion of patients with AF are not prescribed OAC. The aim of this study is to describe the frequencies ... Full text Link to item Cite

DUAL ANTIPLATELET THERAPY AND OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION AND ACUTE CORONARY SYNDROMES

Journal article Journal of the American College of Cardiology · April 2014 Full text Cite

Factors associated with major bleeding events: insights from the ROCKET AF trial (rivaroxaban once-daily oral direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation).

Journal article J Am Coll Cardiol · March 11, 2014 OBJECTIVES: This study sought to report additional safety results from the ROCKET AF (Rivaroxaban Once-daily oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). BACKGROUND ... Full text Link to item Cite

Outcomes of medicare beneficiaries with heart failure and atrial fibrillation.

Journal article JACC Heart Fail · February 2014 OBJECTIVES: This study sought to examine the long-term outcomes of patients hospitalized with heart failure and atrial fibrillation. BACKGROUND: Atrial fibrillation is common among patients hospitalized with heart failure. Associations of pre-existing and ... Full text Link to item Cite

Clinical course of atrial fibrillation in older adults: the importance of cardiovascular events beyond stroke.

Journal article Eur Heart J · January 2014 AIMS: Atrial fibrillation increases the risks of stroke, heart failure, and death, and anticoagulation therapy increases the risk of gastrointestinal haemorrhage. However, the relative event rates for these outcomes are not well described. We sought to def ... Full text Link to item Cite

Efficacy and safety of rivaroxaban compared with warfarin in patients with peripheral artery disease and non-valvular atrial fibrillation: insights from ROCKET AF.

Journal article Eur Heart J · January 2014 AIMS: Vascular disease is included in a risk scoring system to predict stroke in patients with non-valvular atrial fibrillation (AF). This post hoc analysis of ROCKET AF aimed to determine the absolute rates of stroke and bleeding, and the relative effecti ... Full text Link to item Cite

Management of postoperative atrial fibrillation and subsequent outcomes in contemporary patients undergoing cardiac surgery: insights from the Society of Thoracic Surgeons CAPS-Care Atrial Fibrillation Registry.

Journal article Clin Cardiol · January 2014 BACKGROUND: Postoperative atrial fibrillation (POAF) is a well-recognized complication of cardiac surgery; however, its management remains a challenge, and the implementation and outcomes of various strategies in clinical practice remain unclear. HYPOTHESI ... Full text Link to item Cite

Ischaemic cardiac outcomes in patients with atrial fibrillation treated with vitamin K antagonism or factor Xa inhibition: results from the ROCKET AF trial.

Journal article Eur Heart J · January 2014 AIMS: We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. METHODS AND RESULTS: In ROCKET AF, 14 264 patients with nonvalvular AF were randomized t ... Full text Link to item Cite

Relationship between time in therapeutic range and comparative treatment effect of rivaroxaban and warfarin: Results from the ROCKET AF trial

Conference Journal of the American Heart Association · January 1, 2014 Background: Time in therapeutic range (TTR) is a standard quality measure of the use of warfarin. We assessed the relative effects of rivaroxaban versus warfarin at the level of trial center TTR (cTTR) since such analysis preserves randomized comparisons. ... Full text Cite

Anticoagulation and clinical outcomes in heart failure patients with atrial fibrillation: Findings from the ADHERE registry

Journal article Journal of Atrial Fibrillation · December 1, 2013 The risks and benefits of anticoagulation for patients with both heart failure and atrial fibrillation are unclear. We hypothesized that anticoagulation was associated with improved clinical outcomes of heart failure patients with atrial fibrillation indep ... Cite

Anticoagulation and Clinical Outcomes in Heart Failure Patients With Atrial Fibrillation: Findings From the ADHERE Registry.

Journal article J Atr Fibrillation · December 2013 The risks and benefits of anticoagulation for patients with both heart failure and atrial fibrillation are unclear. We hypothesized that anticoagulation was associated with improved clinical outcomes of heart failure patients with atrial fibrillation indep ... Full text Link to item Cite

Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.

Journal article J Am Heart Assoc · November 25, 2013 BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis in atrial fibrillation. Adoption patterns of this new agent in community practice are unknown. METHODS AND RESULTS: We studied patterns of dabigatran use among patients en ... Full text Open Access Link to item Cite

Warfarin use among older atrial fibrillation patients with non-ST-segment elevation myocardial infarction managed with coronary stenting and dual antiplatelet therapy.

Journal article Am Heart J · November 2013 BACKGROUND: We sought to determine the risk of readmission for bleeding and major cardiac events in stented non-ST-segment elevation myocardial infarction (NSTEMI) atrial fibrillation (AF) patients. METHODS: For this patient population, selection of an ant ... Full text Link to item Cite

Comparative effectiveness of pharmacotherapies for prevention of atrial fibrillation following coronary artery bypass surgery.

Journal article Am J Cardiol · October 1, 2013 Risk of atrial fibrillation (AF) after coronary artery bypass grafting (CABG) is high, yet the effectiveness of guideline-recommended preoperative prophylaxis in clinical practice remains uncertain. We determined the utilization and variation of preoperati ... Full text Link to item Cite

Racial differences in the prevalence and outcomes of atrial fibrillation among patients hospitalized with heart failure.

Journal article J Am Heart Assoc · September 26, 2013 BACKGROUND: The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and wa ... Full text Open Access Link to item Cite

Dabigatran for periprocedural anticoagulation following radiofrequency ablation for atrial fibrillation: a meta-analysis of observational studies.

Journal article J Interv Card Electrophysiol · September 2013 PURPOSE: Dabigatran is approved for prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF). The safety and effectiveness of periprocedural dabigatran in ablation for AF are unknown. METHODS: We performed a meta-anal ... Full text Link to item Cite

QRS duration, bundle-branch block morphology, and outcomes among older patients with heart failure receiving cardiac resynchronization therapy.

Journal article JAMA · August 14, 2013 IMPORTANCE: The benefits of cardiac resynchronization therapy (CRT) in clinical trials were greater among patients with left bundle-branch block (LBBB) or longer QRS duration. OBJECTIVE: To measure associations between QRS duration and morphology and outco ... Full text Link to item Cite

Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry.

Journal article Circulation · August 13, 2013 BACKGROUND: The role of concomitant aspirin (ASA) therapy in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) is unclear. We assessed concomitant ASA use and its association with clinical outcomes among AF patients treated with O ... Full text Link to item Cite

Provider specialty and atrial fibrillation treatment strategies in United States community practice: findings from the ORBIT-AF registry.

Journal article J Am Heart Assoc · July 18, 2013 BACKGROUND: The prevalence of atrial fibrillation (AF) continues to increase; however, there are limited data describing the division of care among practitioners in the community and whether care differs depending on provider specialty. METHODS AND RESULTS ... Full text Open Access Link to item Cite

Left atrial remodeling: shape before size?

Journal article J Cardiovasc Electrophysiol · July 2013 Full text Link to item Cite

End of study transition from study drug to open-label vitamin K antagonist therapy: the ROCKET AF experience.

Journal article Circ Cardiovasc Qual Outcomes · July 2013 BACKGROUND: To evaluate the previously reported excess of thromboembolic events during the 30 days after the end of study (EOS) visit when participants transitioned from blinded therapy to open-label vitamin K antagonist. METHODS AND RESULTS: At the EOS vi ... Full text Link to item Cite

Use of evidence-based cardiac prevention therapy among outpatients with atrial fibrillation.

Journal article Am J Med · July 2013 BACKGROUND: Patients with atrial fibrillation often have cardiovascular risk factors or known comorbid disease, yet the use of evidence-based primary and secondary prevention cardiac therapy among atrial fibrillation outpatients is unknown. METHODS: Using ... Full text Link to item Cite

The potential role of nonpharmacologic electrophysiology-based interventions in improving outcomes in patients hospitalized for heart failure.

Journal article Heart Fail Clin · July 2013 Hospitalization for heart failure (HHF) is commonly associated with symptomatic improvement in response to standard medical therapy, yet there remains a substantial risk of rehospitalization and death. Clinically stable outpatients and decompensated inpati ... Full text Link to item Cite

Optimal utilization and management of implanted cardiac rhythm devices in patients hospitalized for heart failure.

Journal article Heart Fail Clin · July 2013 Improved utilization and optimization of device therapy in the management of patients with decompensated heart failure (HF) is an important clinical priority. Diagnostic cardiac rhythm device data have been shown to predict hospitalization for HF. Cardiac ... Full text Link to item Cite

Risks and benefits of anticoagulation in atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article Circ Cardiovasc Qual Outcomes · July 2013 BACKGROUND: Patients with atrial fibrillation (AF) at the highest stroke risk derive the largest benefit from oral anticoagulation (OAC). Those with the highest stroke risk have been paradoxically less likely to receive OAC. This study assessed the associa ... Full text Link to item Cite

Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial.

Journal article Ann Intern Med · June 18, 2013 BACKGROUND: In ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation), a large randomized, clinical trial, rivaroxaban was noninferior to w ... Full text Link to item Cite

Survival benefit of primary prevention implantable cardioverter-defibrillator therapy after myocardial infarction: does time to implant matter? A meta-analysis using patient-level data from 4 clinical trials.

Journal article Heart Rhythm · June 2013 BACKGROUND: Whether there is an optimal time to place an implantable cardioverter-defibrillator (ICD) more than 40 days after myocardial infarction (MI) in guideline-eligible patients is unknown. OBJECTIVE: To evaluate the effect of time from MI to randomi ... Full text Link to item Cite

Atrial fibrillation among Medicare beneficiaries hospitalized with sepsis: incidence and risk factors.

Journal article Am Heart J · June 2013 BACKGROUND: Newly diagnosed atrial fibrillation (AF) during severe sepsis is associated with increased risks of in-hospital stroke and mortality. However, the prevalence, incidence, and risk factors associated with AF during the sepsis syndromes are unclea ... Full text Link to item Cite

Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial.

Journal article J Am Coll Cardiol · May 14, 2013 OBJECTIVES: This study sought to investigate the outcomes following cardioversion or catheter ablation in patients with atrial fibrillation (AF) treated with warfarin or rivaroxaban. BACKGROUND: There are limited data on outcomes following cardioversion or ... Full text Link to item Cite

Impact of using a telescoping-support catheter system for left ventricular lead placement on implant success and procedure time of cardiac resynchronization therapy.

Journal article Pacing Clin Electrophysiol · May 2013 BACKGROUND: Proper positioning of the left ventricular (LV) lead improves clinical outcomes and survival in patients receiving cardiac resynchronization therapy (CRT). Techniques of LV lead insertion using contrast injection and a telescoping system of del ... Full text Link to item Cite

AHA 2012: The 85th Scientific Sessions of American Heart Association

Journal article Therapeutic Research · April 23, 2013 Cite

Rate versus rhythm control for management of atrial fibrillation in clinical practice: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article Am Heart J · April 2013 BACKGROUND: All patients with atrial fibrillation (AF) require optimization of their ventricular rate. Factors leading to use of additional rhythm control in clinical practice have not been thoroughly defined. METHODS: The ORBIT-AF registry enrolled patien ... Full text Link to item Cite

Exercise training and implantable cardioverter-defibrillator shocks in patients with heart failure: results from HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing).

Journal article JACC Heart Fail · April 2013 OBJECTIVES: The purpose of this study was to determine whether exercise training is associated with an increased risk of implantable cardioverter-defibrillator (ICD) therapy in patients with heart failure (HF). BACKGROUND: Few data are available regarding ... Full text Link to item Cite

A Change of Heart

Journal article · March 21, 2013 Cardiac sarcoidosis can present as ventricular ectopy, sustained ventricular arrhythmias, asymptomatic ventricular dysfunction, heart failure, or sudden death. Although 25% of patients with sarcoidosis have evidence of cardiac involvement autopsy, only 5% ... Full text Cite

Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial.

Journal article J Am Heart Assoc · February 19, 2013 BACKGROUND: Vitamin K antagonist (VKA) therapy remains the most common method of stroke prevention in patients with atrial fibrillation. Time in therapeutic range (TTR) is a widely cited measure of the quality of VKA therapy. We sought to identify factors ... Full text Link to item Cite

Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation).

Journal article J Am Coll Cardiol · February 12, 2013 OBJECTIVES: The purpose of this study was to understand the possible risk of discontinuation in the context of clinical care. BACKGROUND: Rivaroxaban is noninferior to warfarin for preventing stroke in atrial fibrillation patients. Concerns exist regarding ... Full text Link to item Cite

Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts.

Journal article Circulation · January 15, 2013 BACKGROUND: We sought to define the factors associated with the occurrence of stroke and systemic embolism in a large, international atrial fibrillation (AF) trial. METHODS AND RESULTS: In ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibitio ... Full text Link to item Cite

Cardiac conduction system disease after transcatheter aortic valve replacement.

Journal article Am Heart J · November 2012 Transcatheter aortic valve replacement (TAVR) is a rapidly-evolving technology for patients with severe, calcific aortic stenosis. Although these procedures lessen many of the risks and complications of open surgical aortic valve replacement, there remain ... Full text Link to item Cite

Outcomes of Medicare beneficiaries undergoing catheter ablation for atrial fibrillation.

Journal article Circulation · October 30, 2012 BACKGROUND: Atrial fibrillation is common among older persons. Catheter ablation is increasingly used in patients for whom medical therapy has failed. METHODS AND RESULTS: We conducted a retrospective cohort study of all fee-for-service Medicare beneficiar ... Full text Link to item Cite

Completion of guideline-recommended initial evaluation of atrial fibrillation.

Journal article Clin Cardiol · October 2012 BACKGROUND: Guidelines recommend evaluation of cardiac function, valvular and ischemic heart disease, and thyroid, kidney, and liver function on initial diagnosis of atrial fibrillation (AF). HYPOTHESIS: We hypothesized that initial workup of patients with ... Full text Link to item Cite

Antithrombotic therapy for atrial fibrillation and coronary artery disease in older patients.

Journal article Am Heart J · October 2012 BACKGROUND: Older patients with atrial fibrillation (AF) and coronary artery disease (CAD) face high risk of stroke and bleeding with antithrombotic therapy. Balancing safe and effective use of aspirin, clopidogrel, and warfarin in this population is impor ... Full text Link to item Cite

Atrial fibrillation complicating acute coronary syndromes

Journal article Journal of Atrial Fibrillation · October 1, 2012 Atrial fibrillation frequently complicates myocardial infarction. Patients with atrial fibrillation complicating acute coronary syndrome have increased morbidity and mortality relative to patients that remain in normal sinus rhythm. No studies have identif ... Cite

Pharmacotherapy in Medicare beneficiaries with atrial fibrillation.

Journal article Heart Rhythm · September 2012 BACKGROUND: There are limited data regarding national patterns of pharmacotherapy for atrial fibrillation (AF) among older patients. Drug exposure data are now captured for Medicare beneficiaries enrolled in prescription drug plans. OBJECTIVE: To describe ... Full text Link to item Cite

Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes.

Journal article Circulation · July 3, 2012 BACKGROUND: Ventricular arrhythmias remain a lethal complication of acute coronary syndromes (ACS). However, the incidence and prognosis of sustained ventricular tachycardia/ventricular fibrillation (VT/VF) in contemporary non-ST-segment-elevation (NSTE) A ... Full text Link to item Cite

International variation in use of oral anticoagulation among heart failure patients with atrial fibrillation.

Journal article Am Heart J · May 2012 BACKGROUND: We sought to characterize patient factors and regional variations associated with vitamin K antagonist (VKA) use in patients with heart failure (HF) and atrial fibrillation (AF) in areas outside the United States and Europe. METHODS: The ADHERE ... Full text Link to item Cite

Retrograde ascending aortic dissection as an early complication of thoracic endovascular aortic repair.

Journal article J Vasc Surg · May 2012 OBJECTIVE: Retrograde ascending aortic dissection (rAAD) is a potential complication of thoracic endovascular aortic repair (TEVAR), yet little data exist regarding its occurrence. This study examines the incidence, etiology, and outcome of this event. MET ... Full text Link to item Cite

Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction.

Journal article Am Heart J · April 2012 BACKGROUND: We aimed to study the comparative safety and effectiveness of various antithrombotic treatment strategies among older adults with non-ST elevation myocardial infarction (NSTEMI) and atrial fibrillation (AF). METHODS: Using the CRUSADE registry ... Full text Link to item Cite

Prognostic significance of postprocedural sustained ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention (from the HORIZONS-AMI Trial).

Journal article Am J Cardiol · March 15, 2012 The prognostic significance of postprocedure sustained ventricular tachycardia or ventricular fibrillation (VT/VF) in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) has rarely be ... Full text Link to item Cite

Atrial Fibrillation Complicating Acute Coronary Syndromes.

Journal article J Atr Fibrillation · 2012 Atrial fibrillation frequently complicates myocardial infarction. Patients with atrial fibrillation complicating acute coronary syndrome have increased morbidity and mortality relative to patients that remain in normal sinus rhythm. No studies have identif ... Full text Link to item Cite

Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007.

Journal article Circ Cardiovasc Qual Outcomes · January 2012 BACKGROUND: Atrial fibrillation (AF) is a common and costly problem among older persons. The frequency of AF increases with age, but representative national data about incidence and prevalence are limited. We examined the annual incidence, prevalence, and ... Full text Link to item Cite

Predictors of mortality in patients with chronic kidney disease and an implantable defibrillator: an EPGEN substudy.

Journal article Europace · December 2011 AIMS: Chronic kidney disease (CKD) is increasingly prevalent, and is an independent risk factor for cardiovascular mortality. Clinical trials of the implantable cardioverter-defibrillator (ICD) have demonstrated a survival benefit over medical therapy for ... Full text Link to item Cite

Stroke prevention in atrial fibrillation.

Journal article Cardiovasc Drugs Ther · December 2011 Full text Link to item Cite

Cryoablation of atrial fibrillation.

Journal article J Interv Card Electrophysiol · December 2011 Atrial fibrillation (AF) is a significant burden to the public health. AF is associated with increased morbidity and mortality, including an increased risk of heart failure, stroke, cognitive impairment, and diminished quality of life. Catheter ablation is ... Full text Link to item Cite

Use of ventricular synchronized triggered atrial pacing to facilitate hemodynamic support during mapping and catheter ablation of ventricular vachycardia.

Journal article J Cardiovasc Electrophysiol · October 2011 Featured Publication Use of VSTAP to Facilitate Hemodynamic Support. The ablation of hemodynamically unstable ventricular tachycardia (VT) is challenging and frequently requires alternative mapping techniques or the use of percutaneous mechanical support devices. Loss of atrio ... Full text Link to item Cite

Outcomes registry for better informed treatment of atrial fibrillation: rationale and design of ORBIT-AF.

Journal article Am Heart J · October 2011 BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and death. Data on contemporary treatment patterns and outcomes associated with AF in clinical practice ... Full text Link to item Cite

Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment.

Journal article Eur Heart J · October 2011 AIMS: Patients with non-valvular atrial fibrillation (AF) and renal insufficiency are at increased risk for ischaemic stroke and bleeding during anticoagulation. Rivaroxaban, an oral, direct factor Xa inhibitor metabolized predominantly by the liver, prese ... Full text Link to item Cite

Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal article N Engl J Med · September 8, 2011 BACKGROUND: The use of warfarin reduces the rate of ischemic stroke in patients with atrial fibrillation but requires frequent monitoring and dose adjustment. Rivaroxaban, an oral factor Xa inhibitor, may provide more consistent and predictable anticoagula ... Full text Link to item Cite

Implantable cardioverter-defibrillator implementation in acute heart failure syndromes: unanswered questions.

Journal article Heart Fail Rev · September 2011 Implantable cardioverter-defibrillators have proven efficacy in reducing mortality in patients with reduced left ventricular ejection fraction in both the primary and the secondary prevention settings. All randomized trials demonstrating this benefit have ... Full text Link to item Cite

Device therapy in heart failure patients with chronic kidney disease.

Journal article J Am Coll Cardiol · August 23, 2011 Heart failure (HF) and chronic kidney disease (CKD) both carry significant risk for sudden cardiac death, hospitalization, and mortality; when combined, however, they markedly increase the risk of morbidity and mortality. Device therapies such as implantab ... Full text Link to item Cite

Relationship of sustained ventricular tachyarrhythmias to outcomes in patients undergoing primary percutaneous coronary intervention with varying underlying baseline risk.

Journal article Am Heart J · April 2011 BACKGROUND: The association of sustained ventricular tachycardia/fibrillation (VT/VF) with mortality in patients undergoing primary percutaneous coronary intervention (PCI) may vary with baseline patient risk and may be associated with higher mortality in ... Full text Link to item Cite

The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.

Journal article Circ Cardiovasc Genet · April 2011 BACKGROUND: Risk-stratifying heart failure patients for primary prevention implantable cardioverter-defibrillators (ICDs) remains a challenge, especially for blacks, who have an increased incidence of sudden cardiac death but have been underrepresented in ... Full text Link to item Cite

Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal article Heart Rhythm · March 2011 Featured Publication BACKGROUND: The implantable cardioverter-defibrillator (ICD) is an effective therapy for preventing sudden cardiac death (SCD) in patients with prior myocardial infarction (MI) and reduced left ventricular function; however, the optimal timing of ICD impla ... Full text Link to item Cite

Extent of and reasons for nonuse of implantable cardioverter defibrillator devices in clinical practice among eligible patients with left ventricular systolic dysfunction.

Journal article Circ Cardiovasc Qual Outcomes · March 2011 BACKGROUND: Several studies that used claims and registry data have reported that 40% to 80% of patients eligible for an implantable cardioverter defibrillator (ICD) fail to receive one in clinical practice, and the rates are especially high among women an ... Full text Link to item Cite

Efficacy of adjunctive ablation of complex fractionated atrial electrograms and pulmonary vein isolation for the treatment of atrial fibrillation: a meta-analysis of randomized controlled trials.

Journal article Europace · February 2011 AIMS: Although useful, percutaneous left atrial ablation for pulmonary vein isolation (PVI) does not eliminate atrial fibrillation (AF) in all patients. The ablation of complex fractionated atrial electrograms (CFAEs) has been proposed as an adjunctive str ... Full text Link to item Cite

Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction.

Journal article Crit Care Med · January 2011 Featured Publication OBJECTIVE: Few data exist to guide antiarrhythmic drug therapy for sustained ventricular tachycardia/ventricular fibrillation after acute myocardial infarction. The objective of this analysis was to describe the survival of patients with sustained ventricu ... Full text Link to item Cite

Do omega-3 fatty acids prevent atrial fibrillation after open heart surgery? A meta-analysis of randomized controlled trials.

Journal article Clinics (Sao Paulo) · 2011 OBJECTIVES: N-3 polyunsaturated fatty acids have been proposed as a novel treatment for preventing postoperative atrial fibrillation due to their potential anti-inflammatory and anti-arrhythmic effects. However, randomized studies have yielded conflicting ... Full text Link to item Cite

Surgical Maze procedure as a treatment for atrial fibrillation: a meta-analysis of randomized controlled trials.

Journal article Cardiovasc Ther · October 2010 Surgical or modified Maze procedures have been promoted to treat atrial fibrillation (AF); however, few randomized controlled clinical trials (RCTs) examine their outcomes. The purpose of this meta-analysis is to compare the efficacy of surgical Maze proce ... Full text Link to item Cite

Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia.

Journal article Circulation · September 21, 2010 BACKGROUND: The role of implantable cardioverter-defibrillator (ICD) in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation (VF) or sustained ventricular tachycardia is an unsolved issue. METHODS AN ... Full text Link to item Cite

Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%.

Journal article J Am Coll Cardiol · July 13, 2010 Featured Publication OBJECTIVES: The aim of this study was to determine whether single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an effective method of risk stratification for sudden cardiac death (SCD) in patients with coronary artery d ... Full text Link to item Cite

Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.

Journal article Curr Opin Cardiol · July 2010 PURPOSE OF REVIEW: Prevention of stroke and systemic emboli is paramount in the management of atrial fibrillation. Although warfarin is the predominant anticoagulant used in patients with atrial fibrillation, it has significant limitations that have impede ... Full text Link to item Cite

Optimal timing of implantable cardioverter-defibrillator implantation after myocardial infarction: a decision analysis.

Journal article J Cardiovasc Electrophysiol · July 2010 Featured Publication BACKGROUND: The optimal timing of implantable cardioverter defibrillator (ICD) placement for the primary prevention of sudden cardiac death after myocardial infarction (MI) remains unknown. METHODS AND RESULTS: We developed a Markov model to investigate th ... Full text Link to item Cite

Remote monitoring of implantable cardioverter defibrillators versus quarterly device interrogations in clinic: results from a randomized pilot clinical trial.

Journal article J Cardiovasc Electrophysiol · May 2010 INTRODUCTION: Remote monitoring is increasingly becoming the new standard of care for implantable cardioverter defibrillator (ICD) follow-up. We sought to determine whether remote monitoring of ICDs improves patient outcomes compared with quarterly device ... Full text Link to item Cite

Reply

Journal article Journal of the American College of Cardiology · March 9, 2010 Full text Cite

Predictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial.

Journal article Eur Heart J · January 2010 Featured Publication AIMS: To determine whether predictors of sudden cardiac death (SCD) vary with time after myocardial infarction (MI). METHODS AND RESULTS: We analysed 11 256 patients enrolled in VALIANT. Landmark analysis and Cox proportional hazards modelling were used to ... Full text Link to item Cite

Implantable cardioverter-defibrillators in patients hospitalized for heart failure with chronically reduced left ventricular ejection fraction.

Journal article Am J Ther · 2010 The aim of this study was to investigate the association between implantable cardioverter-defibrillator (ICD) status at the time of hospitalization for worsening heart failure (HF) with postdischarge events in patients with reduced left ventricular ejectio ... Full text Link to item Cite

Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a meta-analysis of randomized, controlled trials.

Journal article Circ Arrhythm Electrophysiol · December 2009 Featured Publication BACKGROUND: Catheter ablation is an established yet evolving nonpharmacologic intervention for the maintenance of sinus rhythm in patients with atrial fibrillation (AF). The efficacy and safety of pulmonary vein isolation (PVI) compared with medical therap ... Full text Link to item Cite

Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.

Journal article Am Heart J · November 2009 BACKGROUND: Disturbances in cardiac rhythm can lead to significant morbidity and mortality. Many arrhythmias are known to have a heritable component, but the degree to which genetic variation contributes to disease risk and morbidity is poorly understood. ... Full text Link to item Cite

Quality of care for atrial fibrillation among patients hospitalized for heart failure.

Journal article J Am Coll Cardiol · September 29, 2009 Featured Publication OBJECTIVES: This study sought to examine quality of care and warfarin use at discharge in patients with atrial fibrillation (AF) and heart failure (HF). BACKGROUND: Atrial fibrillation is common in HF, and national guidelines recommend discharge on warfari ... Full text Link to item Cite

Comparative efficacy of dronedarone and amiodarone for the maintenance of sinus rhythm in patients with atrial fibrillation.

Journal article J Am Coll Cardiol · September 15, 2009 Featured Publication OBJECTIVES: We sought to compare the efficacy and safety of dronedarone versus amiodarone for the prevention of recurrent atrial fibrillation (AF). BACKGROUND: Dronedarone is a noniodinated amiodarone congener developed to maintain sinus rhythm. Few data a ... Full text Link to item Cite

Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative.

Journal article Am Heart J · September 2009 In October 2008, in a public forum organized by the Cardiac Safety Research Consortium and the Health and Environmental Sciences Institute, leaders from government, the pharmaceutical industry, and academia convened in Bethesda, MD, to discuss current chal ... Full text Link to item Cite

Mode of induction of ventricular tachycardia and prognosis in patients with coronary disease: the Multicenter UnSustained Tachycardia Trial (MUSTT).

Journal article J Cardiovasc Electrophysiol · August 2009 INTRODUCTION: Programmed stimulation is an important prognostic tool in the evaluation of patients with an ejection fraction Full text Link to item Cite

QT as a safety biomarker in drug development.

Journal article Clin Pharmacol Ther · July 2009 The cardiovascular safety of new drugs is an overarching concern for all stakeholders: the pharmaceutical industry and the US Food and Drug Administration (FDA) prior to approval and doctors and patients during postrelease drug use. Of the many cardiac saf ... Full text Link to item Cite

Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials.

Journal article Eur Heart J · May 2009 AIMS: Not all patients at risk for sudden cardiac death (SCD) are eligible for, or have access to implantable cardioverter defibrillator (ICD) implantation. There are conflicting data regarding the efficacy and safety of amiodarone for the prevention of SC ... Full text Link to item Cite

Quality of Care for Atrial Fibrillation Among Patients Hospitalized for Heart Failure

Journal article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

A change of heart.

Journal article J Hosp Med · February 2009 Full text Link to item Cite

Prognostic validation of an algorithm to convert myocardial perfusion SPECT imaging data from a 12-segment model to a 17-segment model.

Journal article J Nucl Cardiol · 2009 BACKGROUND: A 17-segment model has become the standard for interpreting myocardial perfusion single-photon emission computed tomography (SPECT). Methods for converting pre-existing databases from 12-segment models to the 17-segment model are needed for ong ... Full text Link to item Cite

Antithrombotic therapy in atrial fibrillation: guidelines translated for the clinician.

Journal article J Thromb Thrombolysis · December 2008 Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice, accounting for approximately one-third of hospitalizations for cardiac rhythm disturbances. The highest incidence of AF is in patients 70-80 years old and other high-risk ... Full text Link to item Cite

Relation of mortality to failure to prescribe beta blockers acutely in patients with sustained ventricular tachycardia and ventricular fibrillation following acute myocardial infarction (from the VALsartan In Acute myocardial iNfarcTion trial [VALIANT] Registry).

Journal article Am J Cardiol · December 1, 2008 Sustained ventricular arrhythmias and heart failure are well-recognized complications after acute myocardial infarction (AMI) and have been associated with worse outcomes and increased mortality. The use of and outcomes associated with acute beta-blocker t ... Full text Link to item Cite

Single-photon emission computed tomography myocardial perfusion defects are associated with an increased risk of all-cause death, cardiovascular death, and sudden cardiac death.

Journal article Circ Cardiovasc Imaging · November 2008 BACKGROUND: Single-photon emission computed tomography myocardial perfusion imaging defects are associated with increased all-cause mortality and cardiovascular death. However, it is unknown whether single-photon emission computed tomography myocardial per ... Full text Link to item Cite

Early sustained ventricular arrhythmias complicating acute myocardial infarction.

Journal article Am J Med · September 2008 OBJECTIVE: Sustained ventricular arrhythmias complicate 2% to 20% of acute myocardial infarctions (MIs) and are associated with increased in-hospital mortality. However, it remains unclear whether successful mechanical revascularization improves outcomes i ... Full text Link to item Cite

Use of cardiac resynchronization therapy in patients hospitalized with heart failure.

Journal article Circulation · August 26, 2008 Featured Publication BACKGROUND: The frequency and characterization of patients receiving cardiac resynchronization therapy (CRT) are largely unknown since the publication of pivotal clinical trials and subsequent incorporation of CRT into the American College of Cardiology/Am ... Full text Link to item Cite

Rivaroxaban, an oral direct factor Xa inhibitor.

Journal article Expert Opin Investig Drugs · June 2008 Rivaroxaban is a small molecule, direct Factor Xa inhibitor and may be a potentially attractive alternative to vitamin K antagonists. Rivaroxaban is being investigated for the prevention and treatment of venous and arterial thrombosis. A broad search of Me ... Full text Link to item Cite

Combined prednisone and mycophenolate mofetil treatment for retroperitoneal fibrosis.

Journal article J Urol · July 2007 PURPOSE: We determined the efficacy of a combination of corticosteroids and mycophenolate mofetil for retroperitoneal fibrosis. MATERIALS AND METHODS: We performed a prospective observational study of the treatment of 7 patients with biopsy proven retroper ... Full text Link to item Cite

Evolving role of multidetector computed tomography in evaluation of arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal article Am J Cardiol · July 1, 2007 The purpose of this study was to report 1 center's experience with multidetector computed tomography (MDCT) in the evaluation of patients suspected to have arrhythmogenic right ventricular (RV) dysplasia/cardiomyopathy (ARVD/C). RV dilatation/dysfunction i ... Full text Link to item Cite

Diagnostic monitoring strategies in heart failure management.

Journal article Am Heart J · April 2007 Heart failure affects 5 million Americans and is associated with a tremendous economic burden, leading to 26.7 billion dollars in health care expenditures each year (American Heart Association, American Stroke Association. Heart disease and stroke statisti ... Full text Link to item Cite

Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2.

Journal article Circulation · April 4, 2006 BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. A recent study reported mutations in PKP2, encoding the desmosomal pro ... Full text Link to item Cite

Arrhythmogenic right ventricular dysplasia: a United States experience.

Journal article Circulation · December 20, 2005 BACKGROUND: Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. The purpose of our study was to describe the presentation, clinical features, survival, ... Full text Link to item Cite

Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia.

Journal article Heart Rhythm · November 2005 Featured Publication BACKGROUND: Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by ventricular arrhythmias and sudden cardiac death. The risk factors for sudden death and indications for implantable cardioverter-defibrillator (IC ... Full text Link to item Cite

Electrocardiographic findings over time in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal article Am J Cardiol · July 1, 2005 Featured Publication Thirty-five patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy underwent serial electrocardiographic (ECG) testing and were evaluated for evidence of ECG progression. Over a median of 43 months, 89% of the patients had evidence of prog ... Full text Link to item Cite

New insights into diastolic heart failure: role of diabetes mellitus.

Journal article Am J Med · March 8, 2004 Heart failure affects nearly 5 million people in the United States and is a major contributor to mortality, hospitalization, and medical costs. Approximately 40% of patients with heart failure have preserved left ventricular systolic function, thus exhibit ... Full text Link to item Cite

Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice.

Journal article Immunology · December 2000 Chicken antibodies (immunoglobulin Y; IgY) to the alpha Gal epitope (galactose alpha-1,3-galactose) bind to alpha Gal antigens of mouse and porcine tissues and endothelial cells in vitro and block human anti-alpha Gal antibody binding, complement activatio ... Full text Link to item Cite

Rhodopsin maturation antagonized by dominant rhodopsin mutants.

Journal article Vis Neurosci · 1998 ninaE(D1), a dominant allele of the major Drosophila rhodopsin gene, expresses a rhodopsin that is predominantly recovered in a 80-kD complex that likely represents rhodopsin dimers. By driving either ninaE(D1) or ninaE+ expression from a heat-shock promot ... Full text Link to item Cite

Response

Journal article Buddhist-Christian Studies · 1993 Link to item Cite