Jorn Karhausen | Scholars@Duke

Jorn Karhausen
Assistant Professor of Anesthesiology

Current Appointments & Affiliations

Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2020

Contact Information

5688 Hafs, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
jorn.karhausen@duke.edu (919) 684-0862

Background
Education, Training, & Certifications
- M.D., RWTH Aachen University (Germany) 1996
Duke Appointment History
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2012 - 2020
- Medical Instructor in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2010 - 2012
- Clinical Associate in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2009 - 2010
Recognition
In the News
- MAR 19, 2020 Duke Health News
  
  Study IDs Potential Method to Reduce Organ Damage After Heart Surgery
Expertise
Subject Headings
Research
Selected Grants
- Mast cell activation as a determinant of neurologic injury after cardiac arrest awarded by National Institutes of Health 2020 - 2022
- Enhanced neutrophil SUMOylation as a key to anti-inflammatory effects of hypothermia awarded by American Heart Association 2019 - 2021
- Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2021
- Platelets as regulators of inflammation and tissue injury after cardiac surgery awarded by American Heart Association 2015 - 2019
- Platelet/Mast cell Interactions as Determinants of End-Organ Injury in Cardiac Surgery awarded by National Institutes of Health 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Karhausen, Jörn, Hae Woong Choi, Krishna Rao Maddipati, Joseph P. Mathew, Qing Ma, Yacine Boulaftali, Robert Hugh Lee, Wolfgang Bergmeier, and Soman N. Abraham. “Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.” Sci Adv 6, no. 12 (March 2020): eaay6314. https://doi.org/10.1126/sciadv.aay6314.
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  - Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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  - Karhausen, Jörn, Joshua D. Bernstock, Kory R. Johnson, Huaxin Sheng, Qing Ma, Yuntian Shen, Wei Yang, John M. Hallenbeck, and Wulf Paschen. “Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.” Lab Invest 98, no. 6 (June 2018): 799–813. https://doi.org/10.1038/s41374-018-0035-6.
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  - Smeltz, Alan M., Mary Cooter, Srikar Rao, Jörn A. Karhausen, Mark Stafford-Smith, Manuel L. Fontes, and Miklos D. Kertai. “Elevated Pulse Pressure, Intraoperative Hemodynamic Perturbations, and Acute Kidney Injury After Coronary Artery Bypass Grafting Surgery.” J Cardiothorac Vasc Anesth 32, no. 3 (June 2018): 1214–24. https://doi.org/10.1053/j.jvca.2017.08.019.
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  - Oprea, Adriana D., J Mauricio Del Rio, Mary Cooter, Cynthia L. Green, Jörn A. Karhausen, Patrick Nailer, Nicole R. Guinn, et al. “Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study.” Can J Anaesth 65, no. 1 (January 2018): 46–59. https://doi.org/10.1007/s12630-017-0991-0.
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  - Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.
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  - Ghadimi, Kamrouz, Quintin J. Quiñones, and Jörn A. Karhausen. “Identifying Predictors of Gastrointestinal Complications After Cardiovascular Surgery: How Do We Digest the Data?” J Cardiothorac Vasc Anesth 31, no. 4 (August 2017): 1275–77. https://doi.org/10.1053/j.jvca.2017.06.025.
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  - Cobey, Frederick C., Renata Ferreira, W. W. Ursprung, Joern Karhausen, Madhav Swaminathan, and G Burkhard Mackensen. “A Novel Approach to Assess the Three-Dimensional Anatomy of a Mitral Valve Regurgitant Jet Orifice.” J Cardiothorac Vasc Anesth 31, no. 1 (February 2017): 169–73. https://doi.org/10.1053/j.jvca.2016.09.007.
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  - Kertai, Miklos D., Sreekanth Cheruku, Wenjing Qi, Yi-Ju Li, G Chad Hughes, Joseph P. Mathew, and Jörn A. Karhausen. “Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 153, no. 1 (January 2017): 68-76.e2. https://doi.org/10.1016/j.jtcvs.2016.05.063.
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  - Oprea, Adriana D., Frederick W. Lombard, Wen-Wei Liu, William D. White, Jörn A. Karhausen, Yi-Ju Li, Timothy E. Miller, et al. “Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery.” Anesth Analg 123, no. 6 (December 2016): 1480–89. https://doi.org/10.1213/ANE.0000000000001557.
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  - Karhausen, Jörn, and Soman N. Abraham. “How mast cells make decisions.” J Clin Invest 126, no. 10 (October 3, 2016): 3735–38. https://doi.org/10.1172/JCI90361.
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  - Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “In Reply.” Anesthesiology 125, no. 2 (August 2016): 438–39. https://doi.org/10.1097/ALN.0000000000001190.
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  - Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.
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  - Bartels, Karsten, Jörn Karhausen, Breandan L. Sullivan, and G Burkhard Mackensen. “Update on perioperative right heart assessment using transesophageal echocardiography.” Semin Cardiothorac Vasc Anesth 18, no. 4 (December 2014): 341–51. https://doi.org/10.1177/1089253214522326.
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  - Karhausen, Jörn, and Mark Stafford-Smith. “The role of nonocclusive sources of acute gut injury in cardiac surgery.” J Cardiothorac Vasc Anesth 28, no. 2 (April 2014): 379–91. https://doi.org/10.1053/j.jvca.2013.04.016.
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  - Bartels, Karsten, Jörn Karhausen, Eric T. Clambey, Almut Grenz, and Holger K. Eltzschig. “Perioperative organ injury.” Anesthesiology 119, no. 6 (December 2013): 1474–89. https://doi.org/10.1097/ALN.0000000000000022.
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  - Karhausen, Jörn, Ma Qing, Amelia Gibson, Adam J. Moeser, Harald Griefingholt, Laura P. Hale, Soman N. Abraham, and G Burkhard Mackensen. “Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest.” Crit Care Med 41, no. 9 (September 2013): e200–210. https://doi.org/10.1097/CCM.0b013e31827cac7a.
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  - Bartels, K., J. Karhausen, E. T. Clambey, A. Grenz, and H. K. Eltzschig. “Perioperative organ injury.” Anesthesiology 119, no. 6 (January 1, 2013): 1474–89. https://doi.org/10.1097/aln.0000000000000022.
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  - Karhausen, Joern, Roman Dudaryk, Barbara Phillips-Bute, J Daniel Rivera, Fellery de Lange, Carmelo A. Milano, Madhav Swaminathan, and G Burkhard Mackensen. “Three-dimensional transesophageal echocardiography for perioperative right ventricular assessment.” Ann Thorac Surg 94, no. 2 (August 2012): 468–74. https://doi.org/10.1016/j.athoracsur.2012.03.073.
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  - Henes, Janek, Marthe A. Schmit, Julio C. Morote-Garcia, Valbona Mirakaj, David Köhler, Louise Glover, Therese Eldh, et al. “Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury.” Faseb J 23, no. 12 (December 2009): 4244–55. https://doi.org/10.1096/fj.09-138693.
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  - Zheng, Wen, Johannes Kuhlicke, Kristian Jäckel, Holger K. Eltzschig, Anurag Singh, Markus Sjöblom, Brigitte Riederer, et al. “Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium.” Faseb J 23, no. 1 (January 2009): 204–13. https://doi.org/10.1096/fj.08-110221.
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  - Louis, Nancy A., Andreas M. Robinson, Christopher F. MacManus, Jörn Karhausen, Melanie Scully, and Sean P. Colgan. “Control of IFN-alphaA by CD73: implications for mucosal inflammation.” J Immunol 180, no. 6 (March 15, 2008): 4246–55. https://doi.org/10.4049/jimmunol.180.6.4246.
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  - Hartmann, Hanna, Holger K. Eltzschig, Helena Wurz, Klaus Hantke, Alexander Rakin, Amir S. Yazdi, Gianluca Matteoli, et al. “Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.” Gastroenterology 134, no. 3 (March 2008): 756–67. https://doi.org/10.1053/j.gastro.2007.12.008.
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  - Karhausen, Jörn, Martina Nowak, Gregory S. Couper, Vladimir Formanek, Valbona Mirakaj, Andrew Locke, Stanton K. Shernan, and Peter Rosenberger. “Right ventricular dissection diagnosed on transesophageal echocardiography.” Anesth Analg 106, no. 2 (February 2008): 412–14. https://doi.org/10.1213/01.ane.0000295801.66642.b6.
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  - Robinson, Andreas, Simon Keely, Jörn Karhausen, Mark E. Gerich, Glenn T. Furuta, and Sean P. Colgan. “Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.” Gastroenterology 134, no. 1 (January 2008): 145–55. https://doi.org/10.1053/j.gastro.2007.09.033.
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  - Eltzschig, Holger K., Marion Faigle, Simone Knapp, Jorn Karhausen, Juan Ibla, Peter Rosenberger, Kirsten C. Odegard, Peter C. Laussen, Linda F. Thompson, and Sean P. Colgan. “Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.” Blood 108, no. 5 (September 1, 2006): 1602–10. https://doi.org/10.1182/blood-2006-02-001016.
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  - Eltzschig, H. K., J. Karhausen, and V. A. J. Kempf. “Acute oxygen-sensing mechanisms [10].” New England Journal of Medicine 354, no. 9 (March 2, 2006): 976.
  - Eltzschig, Holger K., Jorn Karhausen, and Volkhard A. J. Kempf. “Acute oxygen-sensing mechanisms.” N Engl J Med 354, no. 9 (March 2, 2006): 975–77.
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  - Eltzschig, Holger K., Parween Abdulla, Edgar Hoffman, Kathryn E. Hamilton, Dionne Daniels, Caroline Schönfeld, Michaela Löffler, et al. “HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia.” J Exp Med 202, no. 11 (December 5, 2005): 1493–1505. https://doi.org/10.1084/jem.20050177.
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  - Furuta, Glenn T., Edward E. S. Nieuwenhuis, Jorn Karhausen, Gerald Gleich, Richard S. Blumberg, James J. Lee, and Steven J. Ackerman. “Eosinophils alter colonic epithelial barrier function: role for major basic protein.” Am J Physiol Gastrointest Liver Physiol 289, no. 5 (November 2005): G890–97. https://doi.org/10.1152/ajpgi.00015.2005.
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  - Karhausen, Jörn, Tianqing Kong, Sailaja Narravula, and Sean P. Colgan. “Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression.” J Cell Biochem 95, no. 6 (August 15, 2005): 1264–75. https://doi.org/10.1002/jcb.20489.
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  - Karhausen, Jörn, Volker H. Haase, and Sean P. Colgan. “Inflammatory hypoxia: role of hypoxia-inducible factor.” Cell Cycle 4, no. 2 (February 2005): 256–58.
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  - Eltzschig, Holger K., Linda F. Thompson, Jorn Karhausen, Richard J. Cotta, Juan C. Ibla, Simon C. Robson, and Sean P. Colgan. “Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism.” Blood 104, no. 13 (December 15, 2004): 3986–92. https://doi.org/10.1182/blood-2004-06-2066.
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  - Karhausen, Jörn, Glenn T. Furuta, John E. Tomaszewski, Randall S. Johnson, Sean P. Colgan, and Volker H. Haase. “Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.” J Clin Invest 114, no. 8 (October 2004): 1098–1106. https://doi.org/10.1172/JCI21086.
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  - Kong, Tianqing, Holger K. Eltzschig, Jorn Karhausen, Sean P. Colgan, and C Simon Shelley. “Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.” Proc Natl Acad Sci U S A 101, no. 28 (July 13, 2004): 10440–45. https://doi.org/10.1073/pnas.0401339101.
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  - Comerford, Katrina M., Martin O. Leonard, Jorn Karhausen, Robyn Carey, Sean P. Colgan, and Cormac T. Taylor. “Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.” Proc Natl Acad Sci U S A 100, no. 3 (February 4, 2003): 986–91. https://doi.org/10.1073/pnas.0337412100.
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  - Karhausen, J., J. C. Ibla, and S. P. Colgan. “Implications of hypoxia on mucosal barrier function.” Cell Mol Biol (Noisy Le Grand) 49, no. 1 (February 2003): 77–87.
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  - Synnestvedt, Kristin, Glenn T. Furuta, Katrina M. Comerford, Nancy Louis, Jorn Karhausen, Holger K. Eltzschig, Karl R. Hansen, Linda F. Thompson, and Sean P. Colgan. “Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.” J Clin Invest 110, no. 7 (October 2002): 993–1002. https://doi.org/10.1172/JCI15337.
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  - Comerford, K. M., T. J. Wallace, J. Karhausen, C. T. Taylor, and S. P. Colgan. “Induction of multi-drug resistance (MDR-1) gene by hypoxia.” Journal of the American Society of Nephrology 13 (September 1, 2002): 351A-352A.
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  - Comerford, Katrina M., Timothy J. Wallace, Jörn Karhausen, Nancy A. Louis, Michael C. Montalto, and Sean P. Colgan. “Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.” Cancer Res 62, no. 12 (June 15, 2002): 3387–94.
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  - Taylor, C., K. Comerford, M. Leonard, J. Karhausen, and S. Colgan. “Resolution of hypoxia-elicited epithelial TNF-alpha through SUMO-1 modification of CREB.” Gastroenterology 122, no. 4 (April 1, 2002): A275–A275.
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  - Moldenhauer, G., C. Henne, J. Karhausen, and P. Möller. “Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.” Immunology 96, no. 3 (March 1999): 473–84. https://doi.org/10.1046/j.1365-2567.1999.00676.x.
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  - Kolokythas, O., J. Karhausen, A. von Baer, K. Landgrebe, M. Craciun, and K. Nüssle. “[Radiologic-pathologic conference. Nodular fasciitis].” Rontgenpraxis 50, no. 8 (August 1997): 229–32.
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  - Nussle, K., O. Kolokythas, and J. Karhausen. “Cystic nephroma.” Rontgenpraxis 50, no. 4 (May 12, 1997): 75–76.
  - Folsing, C., F. D. Vogl, J. Karhausen, J. Merk, R. Kreienberg, and A. Rieber. “Krukenberg's tumor: A clinical case report.” Rontgenpraxis 50, no. 2 (April 24, 1997): 31–33.
  - Nussle, K., O. Kolokythas, J. Karhausen, and E. Merkle. “Alveolar cell adenoma of the lung.” Rontgenpraxis 50, no. 2 (April 24, 1997): 29–30.
  - Nüssle, K., O. Kolokythas, and J. Karhausen. “[Cystic nephroma].” Rontgenpraxis 50, no. 4 (April 1997): 75–76.
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  - Fölsing, C., F. D. Vogl, J. Karhausen, J. Merk, R. Kreienberg, and A. Rieber. “[Krukenberg tumor: a clinical case report].” Rontgenpraxis 50, no. 2 (February 1997): 31–33.
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  - Nüssle, K., O. Kolokythas, J. Karhausen, and E. Merkle. “[Alveolar cell adenoma of the lung].” Rontgenpraxis 50, no. 2 (February 1997): 29–30.
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  - Kolokythas, O., J. Karhausen, A. V. Baer, K. Landgrebe, M. Craciun, and K. Nussle. “Radiological-pathological conference: Nodular fasciitis.” Rontgenpraxis 50, no. 8 (January 1, 1997): 229–32.
- Book Sections
  - Karhausen, J., and J. B. Mark. “Routine clinical monitoring.” In Core Topics in Cardiac Anesthesia, Second Edition, 133–40, 2012. https://doi.org/10.1017/CBO9780511979095.027.
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- Conference Papers
  - Karhausen, Jörn A., Wenjing Qi, Alan M. Smeltz, Yi-Ju Li, Svati H. Shah, William E. Kraus, Joseph P. Mathew, Mihai V. Podgoreanu, Miklos D. Kertai, and Miklos D. Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team. “Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.” In Thromb Haemost, 118:1572–85, 2018. https://doi.org/10.1055/s-0038-1667199.
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  - Yerokun, Babatunde A., Jorn Karhausen, David N. Ranney, Ehsan Benrashid, Hanghang Wang, Jeffrey Keenan, Jacob Schroder, Mani Daneshmand, Jeffrey G. Gaca, and G Chad Hughes. “Does Deeper Hypothermia Reduce the Risk of Acute Kidney Injury After Circulatory Arrest for Aortic Arch Surgery?” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Cheruku, Sreekanth, Miklos D. Kertai, Wenjing Qi, Yi-Ju Li, G. C. Hughes, Joseph P. Mathew, and Joern Karhausen. “Mast Cell Activation During Aortic Repair Requiring Circulatory Arrest is Associated With Hemodynamic Instability and Indications of End-Organ Injury.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Base, Karel, Willem W. Lombard, Jorn Karhausen, Huaxin Sheng, and Ivan Spasojevic. “Quantification of Tetrahydrobiopterin (BH4), Dihydrobiopterin (BH2) and Biopterin (BP) in Mouse Brain and Intestines After Ischemic Injury by Liquid Chromatography-Electrospray Tandem Mass Spectrometry (LC-ESI-MS/MS).” In Free Radical Biology and Medicine, 53:S16–S16. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.032.
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  - Karhausen, J., K. Jaeckel, I. Vollmer, M. Faigle, J. Kuhlicke, S. P. Colgan, and H. E. Eltzschig. “Hypoxia responsive mechanisms in mucosal inflammation: implications for barrier integrity and host defense mechanisms.” In International Journal of Medical Microbiology, 297:29–29. ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2007.
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  - Louis, Nancy Anne, Andreas Mark Robinson, Joem Karhausen, Melanie Scully, and Sean Patrick Colgan. “Control of interferon-alphaA by CD73: Implications for mucosal inflammation.” In Faseb Journal, 21:A131–A131. FEDERATION AMER SOC EXP BIOL, 2007.
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Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers