Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., RWTH Aachen University (Germany) 1996
• 

  Duke Appointment History

  • Medical Instructor in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2010 - 2012
  • Clinical Associate in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2009 - 2010
• Expertise
• 

  Subject Headings

  • Acute Kidney Injury
  • Capillary Permeability
  • Cardiopulmonary Bypass
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Cell Culture Techniques
  • Cell Hypoxia
  • Cell Membrane Permeability
  • Circulatory Arrest, Deep Hypothermia Induced
  • Colitis
  • Echocardiography, Three-Dimensional
  • Echocardiography, Transesophageal
  • Epithelial Cells
  • Epithelium
  • Gastrointestinal Diseases
  • Gene Expression Regulation
  • Heart Failure
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Inflammation
  • Intestinal Mucosa
  • Intestines
  • Intraoperative Complications
  • Ischemia
  • Mast Cells
  • Microcirculation
  • Microscopy, Fluorescence
  • Models, Biological
  • Oxygen Consumption
  • Perioperative Period
  • Postoperative Complications
  • Reperfusion Injury
  • SUMO-1 Protein
  • Stroke
  • Systemic Inflammatory Response Syndrome
  • Ventricular Dysfunction, Right
• Research
• 

  Selected Grants

  • Platelets as regulators of inflammation and tissue injury after cardiac surgery awarded by  American Heart Association 2015 - 2019
  • Platelet/Mast Cell Interactions as Determinants of End-Organ Injury in Cardiac Surgery awarded by National Institutes of Health 2015 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Karhausen, J, Bernstock, JD, Johnson, KR, Sheng, H, Ma, Q, Shen, Y, Yang, W, Hallenbeck, JM, and Paschen, W. "Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion." Laboratory Investigation; a Journal of Technical Methods and Pathology 98, no. 6 (June 2018): 799-813.  Full Text
    • Smeltz, AM, Cooter, M, Rao, S, Karhausen, JA, Stafford-Smith, M, Fontes, ML, and Kertai, MD. "Elevated Pulse Pressure, Intraoperative Hemodynamic Perturbations, and Acute Kidney Injury After Coronary Artery Bypass Grafting Surgery." Journal of Cardiothoracic and Vascular Anesthesia 32, no. 3 (June 2018): 1214-1224.  Full Text
    • Oprea, AD, Del Rio, JM, Cooter, M, Green, CL, Karhausen, JA, Nailer, P, Guinn, NR, Podgoreanu, MV, Stafford-Smith, M, Schroder, JN, Fontes, ML, and Kertai, MD. "Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study." Canadian journal of anaesthesia = Journal canadien d'anesthesie 65, no. 1 (January 2018): 46-59.  Full Text
    • Karhausen, JA, Smeltz, AM, Akushevich, I, Cooter, M, Podgoreanu, MV, Stafford-Smith, M, Martinelli, SM, Fontes, ML, and Kertai, MD. "Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery." Anesthesia and Analgesia 125, no. 4 (October 2017): 1129-1139.  Full Text  Open Access Copy
    • Ghadimi, K, Quinones, QJ, and Karhausen, JA. "Identifying Predictors of Gastrointestinal Complications After Cardiovascular Surgery: How Do We Digest the Data?." Journal of Cardiothoracic and Vascular Anesthesia 31, no. 4 (August 1, 2017): 1275-1277.  Full Text  Link to Item
    • Ghadimi, K, Quiñones, QJ, and Karhausen, JA. "Identifying Predictors of Gastrointestinal Complications After Cardiovascular Surgery: How Do We Digest the Data?." Journal of cardiothoracic and vascular anesthesia 31, no. 4 (August 2017): 1275-1277.  Full Text
    • Cobey, FC, Ferreira, R, Ursprung, WW, Karhausen, J, Swaminathan, M, and Mackensen, GB. "A Novel Approach to Assess the Three-Dimensional Anatomy of a Mitral Valve Regurgitant Jet Orifice." Journal of cardiothoracic and vascular anesthesia 31, no. 1 (February 2017): 169-173. (Review)  Full Text
    • Kertai, MD, Cheruku, S, Qi, W, Li, Y-J, Hughes, GC, Mathew, JP, and Karhausen, JA. "Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest." The Journal of thoracic and cardiovascular surgery 153, no. 1 (January 2017): 68-76.e2.  Full Text  Open Access Copy
    • Oprea, AD, Lombard, FW, Liu, W-W, White, WD, Karhausen, JA, Li, Y-J, Miller, TE, Aronson, S, Gan, TJ, Fontes, ML, and Kertai, MD. "Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery." Anesthesia and analgesia 123, no. 6 (December 2016): 1480-1489.  Full Text  Open Access Copy
    • Karhausen, J, and Abraham, SN. "How mast cells make decisions." The Journal of Clinical Investigation 126, no. 10 (October 2016): 3735-3738.  Full Text
    • Kertai, MD, Zhou, S, Karhausen, JA, Cooter, M, Jooste, E, Li, Y-J, White, WD, Aronson, S, Podgoreanu, MV, Gaca, J, Welsby, IJ, Levy, JH, Stafford-Smith, M, Mathew, JP, and Fontes, ML. "In Reply." Anesthesiology 125, no. 2 (August 2016): 438-439. (Letter)  Full Text
    • Kertai, MD, Zhou, S, Karhausen, JA, Cooter, M, Jooste, E, Li, Y-J, White, WD, Aronson, S, Podgoreanu, MV, Gaca, J, Welsby, IJ, Levy, JH, Stafford-Smith, M, Mathew, JP, and Fontes, ML. "Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery." Anesthesiology 124, no. 2 (February 2016): 339-352.  Full Text  Open Access Copy
    • Bartels, K, Karhausen, J, Sullivan, BL, and Mackensen, GB. "Update on perioperative right heart assessment using transesophageal echocardiography." Seminars in cardiothoracic and vascular anesthesia 18, no. 4 (December 2014): 341-351. (Review)  Full Text
    • Karhausen, J, and Stafford-Smith, M. "The role of nonocclusive sources of acute gut injury in cardiac surgery." J Cardiothorac Vasc Anesth 28, no. 2 (April 2014): 379-391. (Review)  Full Text  Link to Item
    • Karhausen, J, and Stafford-Smith, M. "The role of nonocclusive sources of acute gut injury in cardiac surgery." Journal of Cardiothoracic and Vascular Anesthesia 28, no. 2 (January 1, 2014): 379-391. (Review)  Full Text
    • Bartels, K, Karhausen, J, Clambey, ET, Grenz, A, and Eltzschig, HK. "Perioperative organ injury." Anesthesiology 119, no. 6 (December 2013): 1474-1489. (Review)  Full Text
    • Karhausen, J, Qing, M, Gibson, A, Moeser, AJ, Griefingholt, H, Hale, LP, Abraham, SN, and Mackensen, GB. "Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest." Critical Care Medicine 41, no. 9 (September 2013): e200-e210.  Full Text
    • Bartels, K, Karhausen, J, Clambey, ET, Grenz, A, and Eltzschig, HK. "Perioperative organ injury." Anesthesiology 119, no. 6 (January 1, 2013): 1474-1489. (Review)
    • Karhausen, J, Qing, M, Gibson, A, Moeser, AJ, Griefingholt, H, Hale, LP, Abraham, SN, and MacKensen, GB. "Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest." Critical Care Medicine 41, no. 9 (2013): e200-e210.  Full Text
    • Karhausen, J, Dudaryk, R, Phillips-Bute, B, Rivera, JD, de Lange, F, Milano, CA, Swaminathan, M, and Mackensen, GB. "Three-dimensional transesophageal echocardiography for perioperative right ventricular assessment." Ann Thorac Surg 94, no. 2 (August 2012): 468-474.  Full Text  Link to Item
    • Henes, J, Schmit, MA, Morote-Garcia, JC, Mirakaj, V, Köhler, D, Glover, L, Eldh, T, Walter, U, Karhausen, J, Colgan, SP, and Rosenberger, P. "Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 23, no. 12 (December 2009): 4244-4255.  Full Text
    • Zheng, W, Kuhlicke, J, Jäckel, K, Eltzschig, HK, Singh, A, Sjöblom, M, Riederer, B, Weinhold, C, Seidler, U, Colgan, SP, and Karhausen, J. "Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 23, no. 1 (January 2009): 204-213.  Full Text
    • Hartmann, H, Eltzschig, HK, Wurz, H, Hantke, K, Rakin, A, Yazdi, AS, Matteoli, G, Bohn, E, Autenrieth, IB, Karhausen, J, Neumann, D, Colgan, SP, and Kempf, VAJ. "Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores." Gastroenterology 134, no. 3 (March 2008): 756-767.  Full Text  Link to Item
    • Louis, NA, Robinson, AM, MacManus, CF, Karhausen, J, Scully, M, and Colgan, SP. "Control of IFN-alphaA by CD73: implications for mucosal inflammation." Journal of Immunology (Baltimore, Md. : 1950) 180, no. 6 (March 2008): 4246-4255.  Full Text
    • Karhausen, J, Nowak, M, Couper, GS, Formanek, V, Mirakaj, V, Locke, A, Shernan, SK, and Rosenberger, P. "Right ventricular dissection diagnosed on transesophageal echocardiography." Anesth Analg 106, no. 2 (February 2008): 412-414.  Full Text  Link to Item
    • Robinson, A, Keely, S, Karhausen, J, Gerich, ME, Furuta, GT, and Colgan, SP. "Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition." Gastroenterology 134, no. 1 (January 2008): 145-155.  Full Text
    • Eltzschig, HK, Faigle, M, Knapp, S, Karhausen, J, Ibla, J, Rosenberger, P, Odegard, KC, Laussen, PC, Thompson, LF, and Colgan, SP. "Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26." Blood 108, no. 5 (September 2006): 1602-1610.  Full Text
    • Eltzschig, HK, Karhausen, J, and Kempf, VAJ. "Acute oxygen-sensing mechanisms." N Engl J Med 354, no. 9 (March 2, 2006): 975-977. (Letter)  Link to Item
    • Eltzschig, HK, Karhausen, J, and Kempf, VAJ. "Acute oxygen-sensing mechanisms [10]." New England Journal of Medicine 354, no. 9 (2006): 976--.
    • Eltzschig, HK, Abdulla, P, Hoffman, E, Hamilton, KE, Daniels, D, Schönfeld, C, Löffler, M, Reyes, G, Duszenko, M, Karhausen, J, Robinson, A, Westerman, KA, Coe, IR, and Colgan, SP. "HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia." The Journal of Experimental Medicine 202, no. 11 (December 2005): 1493-1505.  Full Text
    • Furuta, GT, Nieuwenhuis, EES, Karhausen, J, Gleich, G, Blumberg, RS, Lee, JJ, and Ackerman, SJ. "Eosinophils alter colonic epithelial barrier function: role for major basic protein." American Journal of Physiology. Gastrointestinal and Liver Physiology 289, no. 5 (November 2005): G890-G897.  Full Text
    • Karhausen, J, Kong, T, Narravula, S, and Colgan, SP. "Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression." J Cell Biochem 95, no. 6 (August 15, 2005): 1264-1275.  Full Text  Link to Item
    • Karhausen, J, Haase, VH, and Colgan, SP. "Inflammatory hypoxia: role of hypoxia-inducible factor." Cell Cycle (Georgetown, Tex.) 4, no. 2 (February 2005): 256-258.
    • Eltzschig, HK, Thompson, LF, Karhausen, J, Cotta, RJ, Ibla, JC, Robson, SC, and Colgan, SP. "Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism." Blood 104, no. 13 (December 2004): 3986-3992.  Full Text
    • Karhausen, J, Furuta, GT, Tomaszewski, JE, Johnson, RS, Colgan, SP, and Haase, VH. "Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis." Journal of Clinical Investigation 114, no. 8 (October 15, 2004): 1098-1106.  Full Text
    • Karhausen, J, Furuta, GT, Tomaszewski, JE, Johnson, RS, Colgan, SP, and Haase, VH. "Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis." Journal of Clinical Investigation 114, no. 8 (October 1, 2004): 1098-1106.  Full Text
    • Karhausen, J, Furuta, GT, Tomaszewski, JE, Johnson, RS, Colgan, SP, and Haase, VH. "Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis." The Journal of Clinical Investigation 114, no. 8 (October 2004): 1098-1106.  Full Text
    • Kong, T, Eltzschig, HK, Karhausen, J, Colgan, SP, and Shelley, CS. "Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression." Proceedings of the National Academy of Sciences of the United States of America 101, no. 28 (July 2, 2004): 10440-10445.  Full Text
    • Comerford, KM, Leonard, MO, Karhausen, J, Carey, R, Colgan, SP, and Taylor, CT. "Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia." Proceedings of the National Academy of Sciences of the United States of America 100, no. 3 (February 2003): 986-991.  Full Text
    • Karhausen, J, Ibla, JC, and Colgan, SP. "Implications of hypoxia on mucosal barrier function." Cell Mol Biol (Noisy-le-grand) 49, no. 1 (February 2003): 77-87. (Review)  Link to Item
    • Synnestvedt, K, Furuta, GT, Comerford, KM, Louis, N, Karhausen, J, Eltzschig, HK, Hansen, KR, Thompson, LF, and Colgan, SP. "Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia." The Journal of Clinical Investigation 110, no. 7 (October 2002): 993-1002.  Full Text
    • Synnestvedt, K, Furuta, GT, Comerford, KM, Louis, N, Karhausen, J, Eltzschig, HK, Hansen, KR, Thompson, LF, and Colgan, SP. "Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia." J Clin Invest 110, no. 7 (October 2002): 993-1002.  Full Text  Link to Item
    • Comerford, KM, Wallace, TJ, Karhausen, J, Taylor, CT, and Colgan, SP. "Induction of multi-drug resistance (MDR-1) gene by hypoxia." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13 (September 2002): 351A-352A.  Link to Item
    • Comerford, KM, Wallace, TJ, Karhausen, J, Louis, NA, Montalto, MC, and Colgan, SP. "Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene." Cancer Research 62, no. 12 (June 2002): 3387-3394.
    • Taylor, C, Comerford, K, Leonard, M, Karhausen, J, and Colgan, S. "Resolution of hypoxia-elicited epithelial TNF-alpha through SUMO-1 modification of CREB." GASTROENTEROLOGY 122, no. 4 (April 2002): A275-A275.  Link to Item
    • Moldenhauer, G, Henne, C, Karhausen, J, and Möller, P. "Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments." Immunology 96, no. 3 (March 1999): 473-484.  Link to Item
    • Kolokythas, O, Karhausen, J, von Baer, A, Landgrebe, K, Craciun, M, and Nüssle, K. "[Radiologic-pathologic conference. Nodular fasciitis]." Rontgenpraxis 50, no. 8 (August 1997): 229-232.  Link to Item
    • Nussle, K, Kolokythas, O, and Karhausen, J. "Cystic nephroma." Rontgenpraxis 50, no. 4 (May 12, 1997): 75-76.
    • Folsing, C, Vogl, FD, Karhausen, J, Merk, J, Kreienberg, R, and Rieber, A. "Krukenberg's tumor: A clinical case report." Rontgenpraxis 50, no. 2 (April 24, 1997): 31-33.
    • Nussle, K, Kolokythas, O, Karhausen, J, and Merkle, E. "Alveolar cell adenoma of the lung." Rontgenpraxis 50, no. 2 (April 24, 1997): 29-30.
    • Nüssle, K, Kolokythas, O, and Karhausen, J. "[Cystic nephroma]." Rontgenpraxis 50, no. 4 (April 1997): 75-76.  Link to Item
    • Fölsing, C, Vogl, FD, Karhausen, J, Merk, J, Kreienberg, R, and Rieber, A. "[Krukenberg tumor: a clinical case report]." Rontgenpraxis 50, no. 2 (February 1997): 31-33.  Link to Item
    • Nüssle, K, Kolokythas, O, Karhausen, J, and Merkle, E. "[Alveolar cell adenoma of the lung]." Rontgenpraxis 50, no. 2 (February 1997): 29-30.  Link to Item
    • Kolokythas, O, Karhausen, J, V Baer, A, Landgrebe, K, Craciun, M, and Nussle, K. "Radiological-pathological conference: Nodular fasciitis." Rontgenpraxis 50, no. 8 (January 1, 1997): 229-232.

  • Book Sections

    • Karhausen, J, and Mark, JB. "Routine clinical monitoring." In Core Topics in Cardiac Anesthesia, Second Edition, 133-140. January 1, 2012.  Full Text

  • Conference Papers

    • Karhausen, JA, Qi, W, Smeltz, AM, Li, Y-J, Shah, SH, Kraus, WE, Mathew, JP, Podgoreanu, MV, Kertai, MD, and Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team, . "Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery." September 2018.  Full Text
    • Cheruku, S, Kertai, MD, Qi, W, Li, Y-J, Hughes, GC, Mathew, JP, and Karhausen, J. "Mast Cell Activation During Aortic Repair Requiring Circulatory Arrest is Associated With Hemodynamic Instability and Indications of End-Organ Injury." November 10, 2015.  Link to Item
    • Base, K, Lombard, WW, Karhausen, J, Sheng, H, and Spasojevic, I. "Quantification of Tetrahydrobiopterin (BH4), Dihydrobiopterin (BH2) and Biopterin (BP) in Mouse Brain and Intestines After Ischemic Injury by Liquid Chromatography-Electrospray Tandem Mass Spectrometry (LC-ESI-MS/MS)." November 1, 2012.  Full Text  Link to Item
    • Karhausen, J, Jaeckel, K, Vollmer, I, Faigle, M, Kuhlicke, J, Colgan, SP, and Eltzschig, HE. "Hypoxia responsive mechanisms in mucosal inflammation: implications for barrier integrity and host defense mechanisms." September 2007.  Link to Item
    • Louis, NA, Robinson, AM, Karhausen, J, Scully, M, and Colgan, SP. "Control of interferon-alphaA by CD73: Implications for mucosal inflammation." April 2007.  Link to Item

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