Overview
My research focus is understanding the earliest processes of disease initiation and progression using systems biology and lineage tracing.
Recent Publications
CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging.
Preprint · May 14, 2025 Full text Link to item CiteNonlinear progression during the occult transition establishes cancer lethality.
Journal Article Dis Model Mech · March 1, 2025 Cancer screening relies upon a linear model of neoplastic growth and progression. Yet, historical observations suggest that malignant progression is uncoupled from growth, which may explain the paradoxical increase in early-stage breast cancer detection wi ... Full text Open Access Link to item CiteA LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease.
Journal Article FASEB J · June 2023 Intestinal epithelial stem cells (ISCs) are responsible for intestinal epithelial barrier renewal; thereby, ISCs play a critical role in intestinal pathophysiology research. While transgenic ISC reporter mice are available, advanced translational studies l ... Full text Link to item CiteRecent Grants
Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory
ResearchResearch Assistant · Awarded by Department of Defense · 2021 - 2026Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
ResearchResearch Assistant · Awarded by National Cancer Institute · 2021 - 2026Recording the natural history of cancer progression using a Crainbow model of HER2+ breast cancer
ResearchResearch Assistant · Awarded by Icahn School of Medicine at Mount Sinai · 2022 - 2024View All Grants