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Joshua Ginzel

Postdoctoral Associate
Cell Biology

Overview


My research focus is understanding the earliest process of disease initiation and progression using systems biology and lineage tracing.

Current Appointments & Affiliations


Postdoctoral Associate Cell Biology, Basic Science Departments

Recent Publications


Nonlinear progression during the occult transition establishes cancer lethality.

Journal Article Dis Model Mech · March 1, 2025 Cancer screening relies upon a linear model of neoplastic growth and progression. Yet, historical observations suggest that malignant progression is uncoupled from growth, which may explain the paradoxical increase in early-stage breast cancer detection wi ... Full text Open Access Link to item Cite

A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease.

Journal Article FASEB J · June 2023 Intestinal epithelial stem cells (ISCs) are responsible for intestinal epithelial barrier renewal; thereby, ISCs play a critical role in intestinal pathophysiology research. While transgenic ISC reporter mice are available, advanced translational studies l ... Full text Link to item Cite
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Recent Grants


Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer

ResearchResearch Assistant · Awarded by National Cancer Institute · 2021 - 2026

Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory

ResearchResearch Assistant · Awarded by Department of Defense · 2021 - 2025

Recording the natural history of cancer progression using a Crainbow model of HER2+ breast cancer

ResearchResearch Assistant · Awarded by Icahn School of Medicine at Mount Sinai · 2022 - 2024

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External Links


Snyder Lab