Overview
My research focus is understanding cancer initiation and progression using systems biology approaches in mouse models.
Recent Publications
Nonlinear progression during the occult transition establishes cancer lethality
Journal Article Disease Models & Mechanisms · March 1, 2025 ABSTRACTCancer screening relies upon a linear model of neoplastic growth and progression. Yet, historical observations suggest that malignant progression is uncoupled from growth, which may explain the parad ... Full text Open Access CiteA LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease.
Journal Article FASEB J · June 2023 Intestinal epithelial stem cells (ISCs) are responsible for intestinal epithelial barrier renewal; thereby, ISCs play a critical role in intestinal pathophysiology research. While transgenic ISC reporter mice are available, advanced translational studies l ... Full text Link to item CiteVeterinary Management of Harderian Gland Tumors in Cancer Rainbow (crainbow) HER2-Positive Mice.
Journal Article Comp Med · December 1, 2022 A Cancer Rainbow mouse line that expresses 3 fluorescently labeled isoforms of the tumor-driver gene HER2 (HER2BOW) was developed recently for the study of tumorigenesis in the mammary gland. The expression of 1 of the 3 HER2 isoforms in HER2BOW mice is in ... Full text Link to item CiteRecent Grants
Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
ResearchResearch Assistant · Awarded by National Cancer Institute · 2021 - 2026Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory
ResearchResearch Assistant · Awarded by Department of Defense · 2021 - 2025Recording the natural history of cancer progression using a Crainbow model of HER2+ breast cancer
ResearchResearch Assistant · Awarded by Icahn School of Medicine at Mount Sinai · 2022 - 2024View All Grants