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Joshua Thomas Thaden

Associate Professor of Medicine
Medicine, Infectious Diseases
DUMC Box 102359, Durham, NC 27710
Rm 201 Alexander H. Sands Buil, 303 Research Drive, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Medicine · 2024 - Present Medicine, Infectious Diseases, Medicine

Recent Publications


Escherichia coli Type III Secretion System 2 (ETT2) is Associated with Patient Mortality in Bloodstream Infections.

Journal Article J Infect Dis · May 22, 2025 BACKGROUND: Escherichia coli has an extensive accessory genome, though its role in impacting patient mortality is unknown. METHODS: We performed whole genome sequencing with E. coli bloodstream infection isolates from inpatients at Duke University. Pan-gen ... Full text Link to item Cite

Early cytokine signatures and clinical phenotypes discriminate persistent from resolving MRSA bacteremia.

Journal Article BMC Infect Dis · February 18, 2025 BACKGROUND: Staphylococcus aureus bacteremia (SAB) is a prevalent life-threatening infection often caused by methicillin-resistant S. aureus (MRSA). Up to 30% of SAB patients fail to clear infection even with gold-standard anti-MRSA antibiotics. This pheno ... Full text Link to item Cite

Combination Therapy Is Not Associated with Decreased Mortality in Infectious Endocarditis: A Systematic Review and Meta-Analysis.

Journal Article Microorganisms · November 2, 2024 Untreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE is recommended by treatment guidelines but largely unsupported by high-quality evidence. This study aimed to assess the efficacy of combination ... Full text Link to item Cite
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Recent Grants


LpxH Inhibitors as Novel Therapeutics Against Multidrug-resistant Enterobacterales

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030

Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

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ResearchPrincipal Investigator · Awarded by DCRI-Duke-Site · 2023 - 2026

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Education, Training & Certifications


Boston University · 2011 M.D.
Boston University · 2011 Ph.D.