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Joshua Thomas Thaden

Associate Professor of Medicine
Medicine, Infectious Diseases
DUMC Box 102359, Durham, NC 27710
Rm 201 Alexander H. Sands Buil, 303 Research Drive, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Medicine · 2024 - Present Medicine, Infectious Diseases, Medicine

Recent Publications


Early cytokine signatures and clinical phenotypes discriminate persistent from resolving MRSA bacteremia.

Journal Article BMC Infect Dis · February 18, 2025 BACKGROUND: Staphylococcus aureus bacteremia (SAB) is a prevalent life-threatening infection often caused by methicillin-resistant S. aureus (MRSA). Up to 30% of SAB patients fail to clear infection even with gold-standard anti-MRSA antibiotics. This pheno ... Full text Link to item Cite

Combination Therapy Is Not Associated with Decreased Mortality in Infectious Endocarditis: A Systematic Review and Meta-Analysis.

Journal Article Microorganisms · November 2, 2024 Untreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE is recommended by treatment guidelines but largely unsupported by high-quality evidence. This study aimed to assess the efficacy of combination ... Full text Link to item Cite

A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease.

Journal Article J Antimicrob Chemother · September 3, 2024 OBJECTIVES: Escherichia coli can cause infections in the urinary tract and in normally sterile body sites leading to invasive E. coli disease (IED), including bacteraemia and sepsis, with older populations at increased risk. We aimed to estimate the theore ... Full text Link to item Cite
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Recent Grants


Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

OPTIMIZE

ResearchPrincipal Investigator · Awarded by DCRI-Duke-Site · 2023 - 2026

Identification of novel pathogen-specific drug targets in gram-negative bacteria (JCVI CDC U54 - Medium Collaborative)

ResearchPrincipal Investigator · Awarded by J. Craig Venter Institute · 2021 - 2025

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Education, Training & Certifications


Boston University · 2011 M.D.
Boston University · 2011 Ph.D.