Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship in Infectious Diseases, Medicine, Duke University School of Medicine 2013 - 2017
  • Internal Medicine Residency, Medicine, Duke University School of Medicine 2011 - 2013
  • M.D., Boston University 2011
  • Ph.D., Boston University 2011
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2018 - 2020
  • Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2017 - 2018
• Research
• 

  Selected Grants

  • Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality awarded by National Institutes of Health 2022 - 2027
  • Identification of novel pathogen-specific drug targets in gram-negative bacteria (JCVI CDC U54 - Medium Collaborative) awarded by J. Craig Venter Institute 2021 - 2023
  • Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
  • IND-enabling studies of the potent LpxC inhibitor LPC-233 as a novel antibiotic against Gram-negative pathogens awarded by Valanbio Therapeutics, Inc. 2020 - 2022
  • Systems Immunobiology of Antibiotic-Persistent MRSA Infections awarded by The Lundquist Institute 2016 - 2021
  • Prospective epidemiological study to estimate the O-serotype distribution of extraintestinal pathogenic Escherichia coli (ExPEC) isolated from hospitalized patients aged 60 years or older with invasive ExPEC disease (IED) and to evaluate the clinical awarded by University Medical Center Utrecht 2019 - 2021
  • Janssen ExPEC Study awarded by Janssen Research & Development, LLC 2019 - 2020
  • VTEU 13-0053 Task Area B: Phase I, single dose, open-label, parallel group study comparing the pharmacokinetics and safety of PA-824 in subjects with mild, moderate, and severe hepatic impairment to matched, normal, healthy subjects. awarded by National Institutes of Health 2014 - 2015
• 

  External Relationships

  • Resonantia Diagnostics, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Eichenberger, Emily M., Jesse Troy, Felicia Ruffin, Michael Dagher, Joshua T. Thaden, Mandy L. Ford, and Vance G. Fowler. “Gram-negative bacteremia in solid organ transplant recipients: Clinical characteristics and outcomes as compared to immunocompetent non-transplant recipients.” Transpl Infect Dis 24, no. 6 (December 2022): e13969. https://doi.org/10.1111/tid.13969.
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    • Thaden, Joshua T., Sarah Cantrell, Michael Dagher, Yazhong Tao, Felicia Ruffin, Stacey A. Maskarinec, Stacy Goins, et al. “Association of Follow-up Blood Cultures With Mortality in Patients With Gram-Negative Bloodstream Infections: A Systematic Review and Meta-analysis.” Jama Netw Open 5, no. 9 (September 1, 2022): e2232576. https://doi.org/10.1001/jamanetworkopen.2022.32576.
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    • Bock, Andrew, Blake M. Hanson, Felicia Ruffin, Joshua B. Parsons, Lawrence P. Park, Batu Sharma-Kuinkel, Michael Mohnasky, Cesar A. Arias, Vance G. Fowler, and Joshua T. Thaden. “Clinical and Molecular Analysis of Recurrent Gram-Negative Bloodstream Infections.” Clin Infect Dis, August 5, 2022. https://doi.org/10.1093/cid/ciac638.
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    • Sinclair, Matthew R., Maria Souli, Felicia Ruffin, Lawrence P. Park, Michael Dagher, Emily M. Eichenberger, Stacey A. Maskarinec, et al. “Staphylococcus aureus Bacteremia Among Patients Receiving Maintenance Hemodialysis: Trends in Clinical Characteristics and Outcomes.” Am J Kidney Dis 79, no. 3 (March 2022): 393-403.e1. https://doi.org/10.1053/j.ajkd.2021.06.018.
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    • Thaden, Joshua T., Pranita D. Tamma, Qing Pan, Yohei Doi, and Nick Daneman. “Survey of infectious diseases providers reveals variability in duration of antibiotic therapy for the treatment of Gram-negative bloodstream infections.” Jac Antimicrob Resist 4, no. 1 (March 2022): dlac005. https://doi.org/10.1093/jacamr/dlac005.
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    • Nasrin, Shamima, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, et al. “Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection.” Bmc Microbiol 22, no. 1 (January 6, 2022): 13. https://doi.org/10.1186/s12866-021-02427-4.
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    • Thaden, Joshua T., Pranita D. Tamma, Yohei Doi, Nick Daneman, and Nick Antibacterial Resistance Leadership Group (ARLG). “Variability in oral antibiotic step-down therapy in the management of Gram-negative bloodstream infections.” Int J Antimicrob Agents 58, no. 6 (December 2021): 106451. https://doi.org/10.1016/j.ijantimicag.2021.106451.
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    • Eichenberger, Emily M., Felicia Ruffin, Michael Dagher, Reginald Lerebours, Sin-Ho Jung, Batu Sharma-Kuinkel, Andrew N. Macintyre, et al. “Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.” Am J Transplant 21, no. 6 (June 2021): 2113–22. https://doi.org/10.1111/ajt.16388.
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    • Chang, Yu-Ling, Maura Rossetti, David W. Gjertson, Liudmilla Rubbi, Michael Thompson, Dennis J. Montoya, Marco Morselli, et al. “Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia.” Proc Natl Acad Sci U S A 118, no. 10 (March 9, 2021). https://doi.org/10.1073/pnas.2000663118.
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    • Thaden, Joshua T., and Stacey A. Maskarinec. “When two for the price of one isn't a bargain: estimating prevalence and microbiology of bacterial co-infections in patients with COVID-19.” Clin Microbiol Infect 26, no. 12 (December 2020): 1602–3. https://doi.org/10.1016/j.cmi.2020.09.002.
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    • Theprungsirikul, J., J. T. Thaden, R. M. Wierzbicki, A. S. Burns, S. Skopelja-Gardner, V. G. Fowler, K. L. Winthrop, I. W. Martin, and W. F. C. Rigby. “Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia.” Infect Immun 88, no. 10 (September 18, 2020). https://doi.org/10.1128/IAI.00444-20.
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    • Wesevich, Austin, Granger Sutton, Felicia Ruffin, Lawrence P. Park, Derrick E. Fouts, Vance G. Fowler, and Joshua T. Thaden. “Newly Named Klebsiella aerogenes (formerly Enterobacter aerogenes) Is Associated with Poor Clinical Outcomes Relative to Other Enterobacter Species in Patients with Bloodstream Infection.” J Clin Microbiol 58, no. 9 (August 24, 2020). https://doi.org/10.1128/JCM.00582-20.
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    • Zhang, Carolyn, Wenchen Song, Helena R. Ma, Xiao Peng, Deverick J. Anderson, Vance G. Fowler, Joshua T. Thaden, Minfeng Xiao, and Lingchong You. “Temporal encoding of bacterial identity and traits in growth dynamics.” Proc Natl Acad Sci U S A 117, no. 33 (August 18, 2020): 20202–10. https://doi.org/10.1073/pnas.2008807117.
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    • Maskarinec, S. A., L. P. Park, F. Ruffin, N. A. Turner, N. Patel, E. M. Eichenberger, D. van Duin, T. Lodise, V. G. Fowler, and J. T. Thaden. “Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia.” Clin Microbiol Infect 26, no. 7 (July 2020): 904–10. https://doi.org/10.1016/j.cmi.2020.01.025.
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    • Dagher, Michael, Felicia Ruffin, Steven Marshall, Magdalena Taracila, Robert A. Bonomo, Rachel Reilly, Vance G. Fowler, and Joshua T. Thaden. “Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.” Open Forum Infect Dis 7, no. 5 (May 2020): ofaa150. https://doi.org/10.1093/ofid/ofaa150.
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    • Choi, Myeongjin, Nicolas Hegerle, Joseph Nkeze, Shaichi Sen, Sanchita Jamindar, Shamima Nasrin, Sunil Sen, et al. “The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive Klebsiella pneumoniae in a Multi-Country Collection.” Front Microbiol 11 (2020): 1249. https://doi.org/10.3389/fmicb.2020.01249.
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    • Bethke, Jonathan H., Adam Davidovich, Li Cheng, Allison J. Lopatkin, Wenchen Song, Joshua T. Thaden, Vance G. Fowler, Minfeng Xiao, and Lingchong You. “Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli.” Sci Adv 6, no. 4 (January 2020): eaax3173. https://doi.org/10.1126/sciadv.aax3173.
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    • Souli, Maria, Felicia Ruffin, Seong-Ho Choi, Lawrence P. Park, Shengli Gao, Nicholas Christopoulos Lent, Batu K. Sharma-Kuinkel, et al. “Changing Characteristics of Staphylococcus aureus Bacteremia: Results From a 21-Year, Prospective, Longitudinal Study.” Clin Infect Dis 69, no. 11 (November 13, 2019): 1868–77. https://doi.org/10.1093/cid/ciz112.
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    • Mba Medie, Felix, Batu K. Sharma-Kuinkel, Felicia Ruffin, Liana C. Chan, Maura Rossetti, Yu-Ling Chang, Lawrence P. Park, et al. “Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.” Proc Natl Acad Sci U S A 116, no. 40 (October 1, 2019): 20087–96. https://doi.org/10.1073/pnas.1909849116.
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    • Mikkaichi, Tsuyoshi, Michael R. Yeaman, Alexander Hoffmann, and Alexander MRSA Systems Immunobiology Group. “Identifying determinants of persistent MRSA bacteremia using mathematical modeling.” Plos Comput Biol 15, no. 7 (July 2019): e1007087. https://doi.org/10.1371/journal.pcbi.1007087.
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    • Eichenberger, Emily M., and Joshua T. Thaden. “Epidemiology and Mechanisms of Resistance of Extensively Drug Resistant Gram-Negative Bacteria.” Antibiotics (Basel) 8, no. 2 (April 6, 2019). https://doi.org/10.3390/antibiotics8020037.
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    • Chan, Liana C., Maura Rossetti, Lloyd S. Miller, Scott G. Filler, Colin W. Johnson, Hong K. Lee, Huiyuan Wang, et al. “Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory.” Proc Natl Acad Sci U S A 115, no. 47 (November 20, 2018): E11111–19. https://doi.org/10.1073/pnas.1808353115.
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    • Thaden, Joshua T., Karen Chiswell, Ian Jaffe, Stephen P. Bergin, William E. Yang, Andrew Romaine, Jamie Roberts, et al. “Pediatric Antibacterial and Antifungal Trials From 2007 to 2017.” Pediatrics 142, no. 3 (September 2018). https://doi.org/10.1542/peds.2017-1849.
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    • Jaslow, Sarah L., Kyle D. Gibbs, W Florian Fricke, Liuyang Wang, Kelly J. Pittman, Mark K. Mammel, Joshua T. Thaden, et al. “Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.” Cell Rep 23, no. 12 (June 19, 2018): 3525–36. https://doi.org/10.1016/j.celrep.2018.05.072.
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    • Thaden, Joshua T., Monica Gandhi, Hideaki Okochi, Christopher B. Hurt, and Mehri S. McKellar. “Seroconversion on preexposure prophylaxis: a case report with segmental hair analysis for timed adherence determination.” Aids 32, no. 9 (June 1, 2018): F1–4. https://doi.org/10.1097/QAD.0000000000001825.
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    • Thaden, Joshua T., Lawrence P. Park, Stacey A. Maskarinec, Felicia Ruffin, Vance G. Fowler, and David van Duin. “Results from a 13-Year Prospective Cohort Study Show Increased Mortality Associated with Bloodstream Infections Caused by Pseudomonas aeruginosa Compared to Other Bacteria.” Antimicrob Agents Chemother 61, no. 6 (June 2017). https://doi.org/10.1128/AAC.02671-16.
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    • Thaden, Joshua T., Jason M. Pogue, and Keith S. Kaye. “Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae.” Virulence 8, no. 4 (May 19, 2017): 403–16. https://doi.org/10.1080/21505594.2016.1207834.
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    • Doi, Yohei, Robert A. Bonomo, David C. Hooper, Keith S. Kaye, James R. Johnson, Cornelius J. Clancy, Joshua T. Thaden, Martin E. Stryjewski, David van Duin, and David Gram-Negative Committee of the Antibacterial Resistance Leadership Group (ARLG)a. “Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group.” Clin Infect Dis 64, no. suppl_1 (March 15, 2017): S30–35. https://doi.org/10.1093/cid/ciw829.
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    • Cyr, D. D., A. S. Allen, G. -. J. Du, F. Ruffin, C. Adams, J. T. Thaden, S. A. Maskarinec, et al. “Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping.” Genes Immun 18, no. 2 (March 2017): 95–99. https://doi.org/10.1038/gene.2017.6.
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    • Doernberg, Sarah B., Thomas P. Lodise, Joshua T. Thaden, Jose M. Munita, Sara E. Cosgrove, Cesar A. Arias, Helen W. Boucher, et al. “Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group.” Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 64, no. suppl_1 (March 2017): S24–29. https://doi.org/10.1093/cid/ciw828.
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    • Thaden, Joshua T., Yanhong Li, Felicia Ruffin, Stacey A. Maskarinec, Jonathan M. Hill-Rorie, Lisa C. Wanda, Shelby D. Reed, and Vance G. Fowler. “Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections.” Antimicrob Agents Chemother 61, no. 3 (March 2017). https://doi.org/10.1128/AAC.01709-16.
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    • Maskarinec, Stacey A., Joshua T. Thaden, Derek D. Cyr, Felicia Ruffin, Maria Souli, and Vance G. Fowler. “The Risk of Cardiac Device-Related Infection in Bacteremic Patients Is Species Specific: Results of a 12-Year Prospective Cohort.” Open Forum Infect Dis 4, no. 3 (2017): ofx132. https://doi.org/10.1093/ofid/ofx132.
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    • Qi, Robert, Hwang-Soo Joo, Batu Sharma-Kuinkel, Nicholas R. Berlon, Lawrence Park, Chih-Lung Fu, Julia A. Messina, et al. “Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus.” J Infect 72, no. 3 (March 2016): 302–8. https://doi.org/10.1016/j.jinf.2015.11.002.
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    • Thaden, Joshua T., Ashley E. Keller, Norah J. Shire, M Margarita Camara, Linda Otterson, Mike Huband, Caitlin M. Guenther, et al. “Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide.” J Infect Dis 213, no. 4 (February 15, 2016): 640–48. https://doi.org/10.1093/infdis/jiv436.
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    • Messina, Julia A., Joshua T. Thaden, Batu K. Sharma-Kuinkel, and Vance G. Fowler. “Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections.” Plos Pathog 12, no. 1 (January 2016): e1005330. https://doi.org/10.1371/journal.ppat.1005330.
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    • Thaden, Joshua T., Vance G. Fowler, Daniel J. Sexton, and Deverick J. Anderson. “Increasing Incidence of Extended-Spectrum β-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States.” Infect Control Hosp Epidemiol 37, no. 1 (January 2016): 49–54. https://doi.org/10.1017/ice.2015.239.
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    • Ruopp, Marcus, Karen Chiswell, Joshua T. Thaden, Kunal Merchant, and Ephraim L. Tsalik. “Respiratory Tract Infection Clinical Trials from 2007 to 2012. A Systematic Review of ClinicalTrials.gov.” Ann Am Thorac Soc 12, no. 12 (December 2015): 1852–63. https://doi.org/10.1513/AnnalsATS.201505-291OC.
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    • Thaden, Joshua T., Jessica E. Ericson, Heather Cross, Stephen P. Bergin, Julia A. Messina, Vance G. Fowler, Daniel K. Benjamin, et al. “Survival Benefit of Empirical Therapy for Staphylococcus aureus Bloodstream Infections in Infants.” Pediatr Infect Dis J 34, no. 11 (November 2015): 1175–79. https://doi.org/10.1097/INF.0000000000000850.
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    • Berlon, Nicholas R., Robert Qi, Batu K. Sharma-Kuinkel, Hwang-Soo Joo, Lawrence P. Park, Dennis George, Joshua T. Thaden, et al. “Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins.” J Infect 71, no. 4 (October 2015): 447–57. https://doi.org/10.1016/j.jinf.2015.06.005.
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    • Bergin, Stephen P., Joshua T. Thaden, Jessica E. Ericson, Heather Cross, Julia Messina, Reese H. Clark, Vance G. Fowler, et al. “Neonatal Escherichia coli Bloodstream Infections: Clinical Outcomes and Impact of Initial Antibiotic Therapy.” Pediatr Infect Dis J 34, no. 9 (September 2015): 933–36. https://doi.org/10.1097/INF.0000000000000769.
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    • Ericson, Jessica E., Joshua Thaden, Heather R. Cross, Reese H. Clark, Vance G. Fowler, Daniel K. Benjamin, Michael Cohen-Wolkowiez, Christoph P. Hornik, P Brian Smith, and P Brian Antibacterial Resistance Leadership Group. “No survival benefit with empirical vancomycin therapy for coagulase-negative staphylococcal bloodstream infections in infants.” Pediatr Infect Dis J 34, no. 4 (April 2015): 371–75. https://doi.org/10.1097/INF.0000000000000573.
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    • Sharma-Kuinkel, Batu K., Yuling Wu, David E. Tabor, Hoyin Mok, Bret R. Sellman, Amy Jenkins, Li Yu, et al. “Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.” J Clin Microbiol 53, no. 1 (January 2015): 227–36. https://doi.org/10.1128/JCM.02023-14.
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    • Eichenberger, Emily M., Joshua T. Thaden, Batu Sharma-Kuinkel, Lawrence P. Park, Thomas H. Rude, Felicia Ruffin, Nina J. Hos, et al. “Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection.” Plos One 10, no. 11 (2015): e0141436. https://doi.org/10.1371/journal.pone.0141436.
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    • Thaden, Joshua T., Sarah S. Lewis, Kevin C. Hazen, Kirk Huslage, Vance G. Fowler, Rebekah W. Moehring, Luke F. Chen, et al. “Rising rates of carbapenem-resistant enterobacteriaceae in community hospitals: a mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the southeastern United States.” Infect Control Hosp Epidemiol 35, no. 8 (August 2014): 978–83. https://doi.org/10.1086/677157.
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    • Yan, Qin, Batu K. Sharma-Kuinkel, Hitesh Deshmukh, Ephraim L. Tsalik, Derek D. Cyr, Joseph Lucas, Christopher W. Woods, et al. “Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.” Plos Pathog 10, no. 6 (June 2014): e1004149. https://doi.org/10.1371/journal.ppat.1004149.
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    • Tong, Steven Y. C., Batu K. Sharma-Kuinkel, Joshua T. Thaden, Adeline R. Whitney, Soo-Jin Yang, Nagendra N. Mishra, Thomas Rude, et al. “Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin.” J Infect Dis 208, no. 3 (August 1, 2013): 520–27. https://doi.org/10.1093/infdis/jit173.
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    • Thaden, Joshua T., Stephen Lory, and Timothy S. Gardner. “Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa.” J Bacteriol 192, no. 10 (May 2010): 2557–68. https://doi.org/10.1128/JB.01528-09.
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    • Faith, Jeremiah J., Boris Hayete, Joshua T. Thaden, Ilaria Mogno, Jamey Wierzbowski, Guillaume Cottarel, Simon Kasif, James J. Collins, and Timothy S. Gardner. “Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles.” Plos Biol 5, no. 1 (January 2007): e8. https://doi.org/10.1371/journal.pbio.0050008.
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