Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship in Infectious Diseases, Medicine, Duke University School of Medicine 2013 - 2017
  • internal Medicine Residency, Medicine, Duke University School of Medicine 2011 - 2013
  • MD./PhD., Boston University 2011
• Research
• 

  Selected Grants

  • Systems Immunobiology of Antibiotic-Persistent MRSA Infections awarded by Harbor-UCLA Research and Education 2016 - 2019
  • VTEU 13-0053 Task Area C awarded by National Institutes of Health 2014 - 2019
  • VTEU 13-0053 Task Area B awarded by National Institutes of Health 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Thaden, JT, Chiswell, K, Jaffe, I, Bergin, SP, Yang, WE, Romaine, A, Roberts, J, Nambiar, S, Farley, J, Benjamin, DK, Smith, PB, and Tsalik, EL. "Pediatric Antibacterial and Antifungal Trials From 2007 to 2017." Pediatrics 142, no. 3 (September 2018).  Full Text
    • Jaslow, SL, Gibbs, KD, Fricke, WF, Wang, L, Pittman, KJ, Mammel, MK, Thaden, JT, Fowler, VG, Hammer, GE, Elfenbein, JR, and Ko, DC. "Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10." Cell Reports 23, no. 12 (June 2018): 3525-3536.  Full Text
    • Thaden, JT, Gandhi, M, Okochi, H, Hurt, CB, and McKellar, MS. "Seroconversion on preexposure prophylaxis: a case report with segmental hair analysis for timed adherence determination." Aids (London, England) 32, no. 9 (June 2018): F1-F4.  Full Text
    • Thaden, JT, Park, LP, Maskarinec, SA, Ruffin, F, Fowler, VG, and van Duin, D. "Results from a 13-Year Prospective Cohort Study Show Increased Mortality Associated with Bloodstream Infections Caused by Pseudomonas aeruginosa Compared to Other Bacteria." Antimicrobial Agents and Chemotherapy 61, no. 6 (June 2017).  Full Text
    • Thaden, JT, Pogue, JM, and Kaye, KS. "Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae." Virulence 8, no. 4 (May 2017): 403-416. (Review)  Full Text
    • Cyr, DD, Allen, AS, Du, G-J, Ruffin, F, Adams, C, Thaden, JT, Maskarinec, SA, Souli, M, Guo, S, Dykxhoorn, DM, Scott, WK, and Fowler, VG. "Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping." Genes and immunity 18, no. 2 (March 23, 2017): 95-99.  Full Text
    • Doernberg, SB, Lodise, TP, Thaden, JT, Munita, JM, Cosgrove, SE, Arias, CA, Boucher, HW, Corey, GR, Lowy, FD, Murray, B, Miller, LG, Holland, TL, and Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG), . "Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 64, no. suppl_1 (March 2017): S24-S29. (Review)  Full Text
    • Doi, Y, Bonomo, RA, Hooper, DC, Kaye, KS, Johnson, JR, Clancy, CJ, Thaden, JT, Stryjewski, ME, van Duin, D, and Gram-Negative Committee of the Antibacterial Resistance Leadership Group (ARLG)a, . "Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 64, no. suppl_1 (March 2017): S30-S35. (Review)  Full Text
    • Thaden, JT, Li, Y, Ruffin, F, Maskarinec, SA, Hill-Rorie, JM, Wanda, LC, Reed, SD, and Fowler, VG. "Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections." Antimicrobial Agents and Chemotherapy 61, no. 3 (March 2017).  Full Text  Open Access Copy
    • Maskarinec, SA, Thaden, JT, Cyr, DD, Ruffin, F, Souli, M, and Fowler, VG. "The Risk of Cardiac Device-Related Infection in Bacteremic Patients Is Species Specific: Results of a 12-Year Prospective Cohort." Open Forum Infectious Diseases 4, no. 3 (January 2017): ofx132-null.  Full Text  Open Access Copy
    • Qi, R, Joo, H-S, Sharma-Kuinkel, B, Berlon, NR, Park, L, Fu, C-L, Messina, JA, Thaden, JT, Yan, Q, Ruffin, F, Maskarinec, S, Warren, B, Chu, VH, Fortes, CQ, Giannitsioti, E, Durante-Mangoni, E, Kanafani, ZA, Otto, M, and Fowler, VG. "Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus." The Journal of Infection 72, no. 3 (March 2016): 302-308.  Full Text
    • Thaden, JT, Keller, AE, Shire, NJ, Camara, MM, Otterson, L, Huband, M, Guenther, CM, Zhao, W, Warrener, P, Stover, CK, Fowler, VG, and DiGiandomenico, A. "Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide." The Journal of Infectious Diseases 213, no. 4 (February 2016): 640-648.  Full Text
    • Messina, JA, Thaden, JT, Sharma-Kuinkel, BK, and Fowler, VG. "Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections." PLoS pathogens 12, no. 1 (January 14, 2016): e1005330-. (Review)  Full Text  Open Access Copy
    • Thaden, JT, Fowler, VG, Sexton, DJ, and Anderson, DJ. "Increasing Incidence of Extended-Spectrum β-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States." Infection control and hospital epidemiology 37, no. 1 (January 2016): 49-54.  Full Text
    • Ruopp, M, Chiswell, K, Thaden, JT, Merchant, K, and Tsalik, EL. "Respiratory Tract Infection Clinical Trials from 2007 to 2012. A Systematic Review of ClinicalTrials.gov." Annals of the American Thoracic Society 12, no. 12 (December 2015): 1852-1863. (Review)  Full Text
    • Thaden, JT, Ericson, JE, Cross, H, Bergin, SP, Messina, JA, Fowler, VG, Benjamin, DK, Clark, RH, Hornik, CP, Smith, PB, and Antibacterial Resistance Leadership Group, . "Survival Benefit of Empirical Therapy for Staphylococcus aureus Bloodstream Infections in Infants." The Pediatric Infectious Disease Journal 34, no. 11 (November 2015): 1175-1179.  Full Text
    • Berlon, NR, Qi, R, Sharma-Kuinkel, BK, Joo, H-S, Park, LP, George, D, Thaden, JT, Messina, JA, Maskarinec, SA, Mueller-Premru, M, Athan, E, Tattevin, P, Pericas, JM, Woods, CW, Otto, M, and Fowler, VG. "Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins." The Journal of infection 71, no. 4 (October 2015): 447-457.  Full Text
    • Bergin, SP, Thaden, JT, Ericson, JE, Cross, H, Messina, J, Clark, RH, Fowler, VG, Benjamin, DK, Hornik, CP, Smith, PB, and Antibacterial Resistance Leadership Group, . "Neonatal Escherichia coli Bloodstream Infections: Clinical Outcomes and Impact of Initial Antibiotic Therapy." The Pediatric Infectious Disease Journal 34, no. 9 (September 2015): 933-936.  Full Text
    • Ericson, JE, Thaden, J, Cross, HR, Clark, RH, Fowler, VG, Benjamin, DK, Cohen-Wolkowiez, M, Hornik, CP, Smith, PB, and Antibacterial Resistance Leadership Group, . "No survival benefit with empirical vancomycin therapy for coagulase-negative staphylococcal bloodstream infections in infants." The Pediatric Infectious Disease Journal 34, no. 4 (April 2015): 371-375.  Full Text
    • Eichenberger, EM, Thaden, JT, Sharma-Kuinkel, B, Park, LP, Rude, TH, Ruffin, F, Hos, NJ, Seifert, H, Rieg, S, Kern, WV, Lower, SK, Fowler, VG, and Kaasch, AJ. "Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection." PloS one 10, no. 11 (January 2015): e0141436-.  Full Text  Open Access Copy
    • Sharma-Kuinkel, BK, Wu, Y, Tabor, DE, Mok, H, Sellman, BR, Jenkins, A, Yu, L, Jafri, HS, Rude, TH, Ruffin, F, Schell, WA, Park, LP, Yan, Q, Thaden, JT, Messina, JA, Fowler, VG, and Esser, MT. "Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia." Journal of Clinical Microbiology 53, no. 1 (January 2015): 227-236.  Full Text
    • Thaden, JT, Lewis, SS, Hazen, KC, Huslage, K, Fowler, VG, Moehring, RW, Chen, LF, Jones, CD, Moore, ZS, Sexton, DJ, and Anderson, DJ. "Rising rates of carbapenem-resistant enterobacteriaceae in community hospitals: a mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the southeastern United States." Infection Control and Hospital Epidemiology 35, no. 8 (August 2014): 978-983.  Full Text
    • Yan, Q, Sharma-Kuinkel, BK, Deshmukh, H, Tsalik, EL, Cyr, DD, Lucas, J, Woods, CW, Scott, WK, Sempowski, GD, Thaden, JT, Rude, TH, Ahn, SH, and Fowler, VG. "Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis." PLoS pathogens 10, no. 6 (June 5, 2014): e1004149-.  Full Text  Open Access Copy
    • Tong, SYC, Sharma-Kuinkel, BK, Thaden, JT, Whitney, AR, Yang, S-J, Mishra, NN, Rude, T, Lilliebridge, RA, Selim, MA, Ahn, SH, Holt, DC, Giffard, PM, Bayer, AS, Deleo, FR, and Fowler, VG. "Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin." The Journal of Infectious Diseases 208, no. 3 (August 2013): 520-527.  Full Text
    • Thaden, JT, Lory, S, and Gardner, TS. "Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa." Journal of Bacteriology 192, no. 10 (May 2010): 2557-2568.  Full Text
    • Faith, JJ, Hayete, B, Thaden, JT, Mogno, I, Wierzbowski, J, Cottarel, G, Kasif, S, Collins, JJ, and Gardner, TS. "Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles." Plos Biology 5, no. 1 (January 2007): e8-null.  Full Text

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