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Joshua Thomas Thaden

Associate Professor of Medicine
Medicine, Infectious Diseases
DUMC Box 102359, Durham, NC 27710
Rm 201 Alexander H. Sands Buil, 303 Research Drive, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Medicine · 2024 - Present Medicine, Infectious Diseases, Medicine

Recent Publications


Escherichia coli Type III Secretion System 2 Is Associated With Patient Mortality in Bloodstream Infections.

Journal Article J Infect Dis · November 14, 2025 BACKGROUND: Escherichia coli has an extensive accessory genome, though its role in affecting patient mortality is unknown. METHODS: We performed whole genome sequencing with E. coli bacteremia isolates. Pan-genome analysis was used to identify flexible gen ... Full text Link to item Cite

Female Sex and Mortality in Patients With Gram-Negative Bacteremia: A Systematic Review and Meta-Analysis.

Journal Article JAMA Netw Open · November 3, 2025 IMPORTANCE: Female sex has been identified as a risk factor for mortality in Staphylococcus aureus bloodstream infection (SA-BSI). It is unknown whether this association extends to bloodstream infections with other bacterial species. OBJECTIVE: To investig ... Full text Link to item Cite
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Recent Grants


LpxH Inhibitors as Novel Therapeutics Against Multidrug-resistant Enterobacterales

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030

Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

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ResearchPrincipal Investigator · Awarded by DCRI-Duke-Site · 2023 - 2026

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Education, Training & Certifications


Boston University · 2011 M.D.
Boston University · 2011 Ph.D.