Scholars@Duke
Juan Marcos Gonzalez

Juan Marcos Gonzalez

Associate Professor in Population Health Sciences
Population Health Sciences
jm.gonzalez@duke.edu
200 Morris Street, Durham, NC 27701
200 Morris Street, Durham, NC 27701

Selected Publications

Quantifying patients' preferences on tradeoffs between mortality risk and reduced need for target vessel revascularization for claudication.

Journal Article Vasc Med · December 2024 BACKGROUND: In 2019, the US Food and Drug Administration issued a warning that symptomatic relief from claudication using paclitaxel-coated devices might be associated with an increase in mortality over 5 years. We designed a discrete-choice experiment (DC ... Full text Link to item Cite

Participant Engagement and Preference Study for Clinical Outcomes Associated With Atrial Fibrillation: The PEARL-AF Study.

Journal Article JACC Adv · December 2024 BACKGROUND: Quantifying patients' preferences for health outcomes associated with atrial fibrillation (AF) and its treatments offers a replicable approach to considering the patient perspective in regulatory decision-making. OBJECTIVE: The authors conducte ... Full text Link to item Cite

To pool or not to pool: Accounting for task non-attendance in subgroup analysis

Journal Article Journal of Choice Modelling · June 1, 2024 Pooling data from different subgroups offers advantages of shrinking standard errors and simplifying characterization of the data structure. The ability to pool data also facilitates meta-analysis to evaluate consensus among multiple studies and to inform ... Full text Cite

Getting it right with discrete choice experiments: Are we hot or cold?

Journal Article Soc Sci Med · May 2024 Discrete Choice Experiments (DCEs) are widely employed survey-based methods to assess preferences for healthcare services and products. While they offer an experimental way to represent health-related decisions, the stylized representation of scenarios in ... Full text Link to item Cite

Non-Fusion Versus Fusion Surgery in Pediatric Idiopathic Scoliosis: What Trade-Offs in Outcomes Are Acceptable for the Patient and Family?

Journal Article J Bone Joint Surg Am · January 3, 2024 BACKGROUND: Vertebral body tethering and other non-fusion techniques for the treatment of pediatric idiopathic scoliosis are increasing in popularity. There is limited physician consensus on this topic as the result of a paucity of published data regarding ... Full text Link to item Cite

Preferences for potential benefits and risks for gene therapy in the treatment of sickle cell disease.

Journal Article Blood Adv · December 12, 2023 Objective of this study is to quantify benefit-risk tradeoffs pertaining to potential gene therapies among adults and parents/caregivers of children with sickle cell disease (SCD). A discrete-choice experiment survey was developed in which respondents sele ... Full text Link to item Cite

Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers.

Journal Article Clin J Am Soc Nephrol · December 1, 2023 BACKGROUND: In the United States, more than 50% of kidneys in the lowest 15% quality range (those with Kidney Donor Profile Index >85) are discarded. Studies suggest that using more of these kidneys could benefit patients waiting for a transplant. This stu ... Full text Link to item Cite

Discrete-Choice Experiment to Understand the Preferences of Patients with Hormone-Sensitive Prostate Cancer in the USA, Canada, and the UK.

Journal Article Patient · November 2023 BACKGROUND: Treatment options for patients with metastatic hormone-sensitive prostate cancer (mHSPC) have broadened, and treatment decisions can have a long-lasting impact on patients' quality of life. Data on patient preferences can improve therapeutic de ... Full text Link to item Cite

How Much Better is Faster? Value Adjustments for Health-Improvement Sequences.

Journal Article Pharmacoeconomics · August 2023 While the quality-adjusted life-year construct has advantages of simplicity and consistency, simplicity requires strong assumptions. In particular, standard assumptions result in health-state utility functions that are unrealistically linear and separable ... Full text Link to item Cite

How Does the Public Evaluate Vaccines for Low-Incidence, Severe-Outcome Diseases? A General-Population Choice Experiment.

Journal Article Patient · March 2023 BACKGROUND: Because immunizing large numbers of healthy people could be required to reduce a relatively small number of infections, disease incidence has a large impact on cost effectiveness, even if the infection is associated with very serious health out ... Full text Link to item Cite

Patient-Preference Diagnostics: Adapting Stated-Preference Methods to Inform Effective Shared Decision Making.

Journal Article Med Decis Making · February 2023 BACKGROUND: While clinical practice guidelines underscore the need to incorporate patient preferences in clinical decision making, incorporating meaningful assessment of patient preferences in clinical encounters is challenging. Structured approaches that ... Full text Open Access Link to item Cite

Method for Calculating the Simultaneous Maximum Acceptable Risk Threshold (SMART) from Discrete-Choice Experiment Benefit-Risk Studies.

Journal Article Med Decis Making · February 2023 BACKGROUND: Medical decisions require weighing expected benefits of treatment against multiple adverse outcomes under uncertainty (i.e., risks) that must be accepted as a bundle. However, conventional maximum acceptable risk (MAR) estimates derived from di ... Full text Link to item Cite

Patient perspectives on considerations, tradeoffs, and experiences with multiple myeloma treatment selection: a qualitative descriptive study.

Journal Article BMC Cancer · January 19, 2023 BACKGROUND: Advances in multiple myeloma treatment and a proliferation of treatment options have resulted in improved survival rates and periods of symptom-free remission for many multiple myeloma patients. As a result, health-related quality of life (HRQo ... Full text Link to item Cite

Use of Patient Preferences Data Regarding Multiple Risks to Inform Regulatory Decisions.

Journal Article MDM Policy Pract · 2023 UNLABELLED: Background and Objectives. Risk-tolerance measures from patient-preference studies typically focus on individual adverse events. We recently introduced an approach that extends maximum acceptable risk (MAR) calculations to simultaneous maximum ... Full text Link to item Cite

Did a bot eat your homework? An assessment of the potential impact of bad actors in online administration of preference surveys.

Journal Article PLoS One · 2023 BACKGROUND: Online administration of surveys has a number of advantages but can also lead to increased exposure to bad actors (human and non-human bots) who can try to influence the study results or to benefit financially from the survey. We analyze data c ... Full text Link to item Cite

A Quantitative Framework for Medication Non-Adherence: Integrating Patient Treatment Expectations and Preferences.

Journal Article Patient Prefer Adherence · 2023 INTRODUCTION: Medication non-adherence remains a significant challenge in healthcare, impacting treatment outcomes and the overall effectiveness of medical interventions. This article introduces a novel approach to understanding and predicting medication n ... Full text Open Access Link to item Cite

Patient Preferences for Waiting Time and Kidney Quality.

Journal Article Clin J Am Soc Nephrol · September 2022 BACKGROUND AND OBJECTIVES: Approximately 20% of deceased donor kidneys are discarded each year in the United States. Some of these kidneys could benefit patients who are waitlisted. Understanding patient preferences regarding accepting marginal-quality kid ... Full text Link to item Cite

A Guide to Observable Differences in Stated Preference Evidence.

Journal Article Patient · May 2022 BACKGROUND AND OBJECTIVE: In health preference research, studies commonly hypothesize differences in parameters (i.e., differential or joint effects on attribute importance) and/or in choice predictions (marginal effects) by observable factors. Discrete ch ... Full text Link to item Cite

Accounting for Preference Heterogeneity in Discrete-Choice Experiments: An ISPOR Special Interest Group Report.

Journal Article Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · May 2022 ObjectivesDiscrete choice experiments (DCEs) are increasingly used to elicit preferences for health and healthcare. Although many applications assume preferences are homogenous, there is a growing portfolio of methods to understand both explained ... Full text Cite

What is a Good Death? A Choice Experiment on Care Indicators for Patients at End of Life.

Journal Article J Pain Symptom Manage · April 2022 CONTEXT: Health systems should aim to deliver on what matters most to patients. With respect to end of life (EOL) care, knowledge on patient preferences for care is currently lacking. OBJECTIVES: To quantify preference weights for key EOL care indicators. ... Full text Link to item Cite

Quantifying Benefit-Risk Preferences for Heart Failure Devices: A Stated-Preference Study.

Journal Article Circ Heart Fail · January 2022 BACKGROUND: Regulatory and clinical decisions involving health technologies require judgements about relative importance of their expected benefits and risks. We sought to quantify heart-failure patients' acceptance of therapeutic risks in exchange for imp ... Full text Link to item Cite

Primary Immune Deficiency: Patients' Preferences for Replacement Immunoglobulin Therapy.

Journal Article Front Immunol · 2022 PURPOSE: Immunoglobulin (Ig) replacement therapy is an important life-saving treatment modality for patients with primary antibody immune deficiency disorders (PAD). IVIG and SCIg are suitable alternatives to treat patients with PAD but vary in key ways. E ... Full text Link to item Cite

An Evidence Base for Stated-Preference Research: Proving the Concept

Conference PATIENT-PATIENT CENTERED OUTCOMES RESEARCH · 2022 Cite

Patient Preferences for Outcomes Following DCIS Management Strategies: A Discrete Choice Experiment.

Journal Article JCO Oncol Pract · November 2021 PURPOSE: Ductal carcinoma in situ (DCIS), a nonobligate precursor of breast cancer, is often aggressively managed with multimodal therapy. However, there is limited research on patients' preferences for trade-offs among treatment-related outcomes such as b ... Full text Link to item Cite

The Impact of the Risk Functional Form Assumptions on Maximum Acceptable Risk Measures.

Journal Article Patient · November 2021 BACKGROUND: Discrete-choice experiments (DCEs) are increasingly conducted to quantify risk tolerance by computing maximum acceptable risk (MAR) for improvements in efficacy or other benefits gained from new medical treatments. To compute MARs from DCE data ... Full text Link to item Cite

Incomplete information and irrelevant attributes in stated-preference values for health interventions.

Journal Article Health Econ · November 2021 Violations of the assumptions of complete information [CI] and independence of irrelevant alternatives (IIA) in discrete-choice experiment (DCE) data imply sensitivity of preference estimates to the decision context and the alternatives evaluated. There is ... Full text Link to item Cite

Quantifying Value of Hope.

Journal Article Value Health · October 2021 BACKGROUND: 'Hope' is a construct in patient-centered value frameworks, but few studies have attempted to measure the value of hope separately from treatment-related gains in quality of life and survival to support its application in economic evaluation. O ... Full text Link to item Cite

Heterogeneity in Parent Preferences for Peanut Desensitization Therapy.

Journal Article J Allergy Clin Immunol Pract · September 2021 BACKGROUND: Recently developed peanut desensitization treatment reduces the incidence of allergic reactions, the anxiety associated with the risk of accidental exposure, and the burden of precautionary behavior. Eliciting parent preferences for tradeoffs i ... Full text Link to item Cite

Who Would Pay Higher Taxes for Better Mental Health? Results of a Large-Sample National Choice Experiment.

Journal Article Milbank Q · September 2021 UNLABELLED: Policy Points  Public funding for mental health programs must compete with other funding priorities in limited state budgets.  Valuing state-funded mental health programs in a policy-relevant context requires consideration of how much benefit f ... Full text Link to item Cite

The preferences of women with ovarian cancer for oral versus intravenous recurrence regimens.

Journal Article Gynecol Oncol · August 2021 OBJECTIVE: To assess preferences of women with ovarian cancer regarding features of available anti-cancer regimens for platinum-resistant, biomarker-positive disease, with an emphasis on oral PARP inhibitor and standard intravenous (IV) chemotherapy regime ... Full text Link to item Cite

Surgical treatment for recurrent shoulder instability: factors influencing surgeon decision making.

Journal Article J Shoulder Elbow Surg · March 2021 BACKGROUND: The optimal surgical approach for recurrent anterior shoulder instability remains controversial, particularly in the face of glenoid and/or humeral bone loss. The purpose of this study was to use a contingent-behavior questionnaire (CBQ) to det ... Full text Link to item Cite

Parental preferences for vesicoureteral reflux treatment: Profile case best-worst scaling.

Journal Article J Pediatr Urol · February 2021 INTRODUCTION: Vesicoureteral reflux is a common pediatric urologic condition that often has several reasonable treatment options depending on condition severity. In order to choose the best treatment for their child, parents are expected to make judgements ... Full text Link to item Cite

The Faster, the Better: QALY Distortions in Valuing Speed of Onset of Action

Conference PATIENT-PATIENT CENTERED OUTCOMES RESEARCH · 2021 Cite

Patient Preferences for Surgical Treatment of Knee Osteoarthritis: A Discrete-Choice Experiment Evaluating Total and Unicompartmental Knee Arthroplasty.

Journal Article J Bone Joint Surg Am · December 2, 2020 BACKGROUND: Total knee arthroplasty (TKA) is a common treatment for end-stage knee osteoarthritis but is associated with increased complication rates compared with unicompartmental knee arthroplasty (UKA). UKA offers better functional outcomes but is assoc ... Full text Link to item Cite

Willingness to Accept Trade-Offs Among COVID-19 Cases, Social-Distancing Restrictions, and Economic Impact: A Nationwide US Study.

Journal Article Value Health · November 2020 OBJECTIVE: To conduct a discrete-choice experiment to quantify Americans' acceptance of severe acute respiratory syndrome coronavirus 2 infection risks for earlier lifting of social-distancing restrictions and diminishing the pandemic's economic impact. ME ... Full text Link to item Cite

Patient Preferences Around Extent of Surgery in Low-Risk Thyroid Cancer: A Discrete Choice Experiment.

Journal Article Thyroid · July 2020 Background: Patient preferences pertaining to surgical options for thyroid cancer management are not well studied. Our aim was to conduct a discrete choice experiment (DCE) to characterize participants' views on the relative importance of various risks and ... Full text Link to item Cite

Promoting HIV Testing by Men: A Discrete Choice Experiment to Elicit Preferences and Predict Uptake of Community-based Testing in Uganda.

Journal Article Appl Health Econ Health Policy · June 2020 BACKGROUND AND OBJECTIVES: HIV testing is essential to access HIV treatment and care and plays a critical role in preventing transmission. Despite this, testing coverage is low among men in sub-Saharan Africa. Community-based testing has demonstrated poten ... Full text Link to item Cite

Patient preferences for maintenance PARP inhibitor therapy in ovarian cancer treatment.

Journal Article Gynecol Oncol · March 2020 OBJECTIVE: To measure preferences of women with ovarian cancer regarding risks, side effects, costs and benefits afforded by maintenance therapy (MT) with a poly ADP ribose polymerase (PARP) inhibitor. METHODS: A discrete-choice experiment elicited prefere ... Full text Link to item Cite

Why Do People Living with HIV Adhere to Antiretroviral Therapy and Not Comorbid Cardiovascular Disease Medications? A Qualitative Inquiry.

Journal Article Patient Prefer Adherence · 2020 BACKGROUND: After achieving viral suppression, it is critical for persons living with HIV (PLWH) to focus on prevention of non-AIDS comorbidities such as cardiovascular disease (CVD) in order to enhance their quality of life and longevity of life. Despite ... Full text Open Access Link to item Cite

Do Patient Preferences Align With Value Frameworks? A Discrete-Choice Experiment of Patients With Breast Cancer.

Journal Article MDM Policy Pract · 2020 Purpose. Assess patient preferences for aspects of breast cancer treatments to evaluate and inform the usual assumptions in scoring rubrics for value frameworks. Methods. A discrete-choice experiment (DCE) was designed and implemented to collect quantitati ... Full text Link to item Cite

Patients' Willingness to Accept Mitral Valve Procedure-Associated Risks Varies Across Severity of Heart Failure Symptoms.

Journal Article Circ Cardiovasc Interv · December 2019 BACKGROUND: The Food and Drug Administration's Center for Drugs and Radiological Health issued Guidance in 2016 on generating patient preference information to aid evaluation of medical devices. Consistent with this guidance, we aimed to provide quantitati ... Full text Link to item Cite

A Guide to Measuring and Interpreting Attribute Importance.

Journal Article Patient · June 2019 Stated-preference (SP) methods, such as discrete-choice experiments (DCE) and best-worst scaling (BWS), have increasingly been used to measure preferences for attributes of medical interventions. Preference information is commonly characterized using attri ... Full text Link to item Cite

Parental Preferences for Vesicoureteral Reflux Treatment: A Crowd-sourced, Best-worst Scaling Study.

Journal Article Urology · June 2019 OBJECTIVE: To quantitatively evaluate parental preferences for the various treatments for vesicoureteral reflux using crowd-sourced best-worst scaling, a novel technique in urologic preference estimation. METHODS: Preference data were collected from a comm ... Full text Open Access Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Journal Article Contemp Clin Trials · January 2019 Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety o ... Full text Open Access Link to item Cite

Trading Health Risks for Glory: A Reformulation of the Goldman Dilemma.

Journal Article Sports Med · August 2018 BACKGROUND: The Goldman dilemma presented athletes with a Faustian bargain that guaranteed winning an Olympic gold medal in their sport but resulted in certain death 5 years later. Athletes' responses to Goldman's bargain were reported from 1982 to 1995. S ... Full text Link to item Cite

Comparing the Relative Importance of Attributes of Metastatic Renal Cell Carcinoma Treatments to Patients and Physicians in the United States: A Discrete-Choice Experiment.

Journal Article Pharmacoeconomics · August 2018 OBJECTIVES: Value assessments of new treatments for metastatic renal cell carcinoma (RCC) should include outcomes that are most important to patients. This study aimed to quantify and compare the conditional relative importance of the attributes of RCC tre ... Full text Link to item Cite

Evaluating Risk Tolerance from a Systematic Review of Preferences: The Case of Patients with Psoriasis.

Journal Article Patient · June 2018 BACKGROUND: Stated-preference methods have been widely used to evaluate patient-relative preferences for the benefits and potential harms of psoriasis treatments. However, risk tolerance measures for treatment-related harms, a corollary of preferences, are ... Full text Link to item Cite

Quantifying the importance of inhaler attributes corresponding to items in the patient satisfaction and preference questionnaire in patients using Combivent Respimat.

Journal Article Health Qual Life Outcomes · October 16, 2017 BACKGROUND: Physicians consider ease of use, satisfaction, and preferences when prescribing an inhaler device. These factors may impact appropriate usage and compliance. METHODS: The objectives were to quantify the relative importance of inhaler attributes ... Full text Open Access Link to item Cite

Benefits of Emergency Departments' Contribution to Stroke Prophylaxis in Atrial Fibrillation: The EMERG-AF Study (Emergency Department Stroke Prophylaxis and Guidelines Implementation in Atrial Fibrillation).

Journal Article Stroke · May 2017 BACKGROUND AND PURPOSE: Long-term benefits of initiating stroke prophylaxis in the emergency department (ED) are unknown. We analyzed the long-term safety and benefits of ED prescription of anticoagulation in atrial fibrillation patients. METHODS: Prospect ... Full text Link to item Cite

Comparing preferences for outcomes of psoriasis treatments among patients and dermatologists in the U.K.: results from a discrete-choice experiment.

Journal Article Br J Dermatol · March 2017 Featured Publication BACKGROUND: Plaque psoriasis can have a significant negative effect on patients' quality of life, and treatments can result in serious toxicities. Although there have been several studies of patients' and physicians' relative preferences for the benefits a ... Full text Link to item Cite

Caregiver preferences for increasing patient survival in advanced melanoma.

Conference Journal of Clinical Oncology · February 10, 2017 185 Background: Patients with advanced cancer and their caregivers may often accept shorter life expectancy to ensure higher quality of remaining months of life. Our objective was to elicit caregiver preferences for quality-adjus ... Full text Cite

Benefit-risk tradeoff preferences for chronic hand eczema treatments.

Journal Article J Dermatolog Treat · February 2017 Hand eczema affects approximately 16% of the US population. The long-term prognosis is poor, and 5-7% experience severe chronic hand eczema (sCHE) that interferes with daily activities. Treatments for CHE may be ineffective or associated with adverse event ... Full text Link to item Cite

Estimating Preferences for Complex Health Technologies: Lessons Learned and Implications for Personalized Medicine.

Journal Article Value Health · January 2017 We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example of genomic testing. Assessing the value of WGS is complex because WGS provides multiple findings, some of ... Full text Link to item Cite

Patient and physician preferences for anticancer drugs for the treatment of metastatic colorectal cancer: a discrete-choice experiment.

Journal Article Cancer Manag Res · 2017 OBJECTIVE: Many publications describe preferences for colorectal cancer (CRC) screening; however, few studies elicited preferences for anticancer-drug treatment for metastatic CRC (mCRC). This study was designed to elicit preferences and risk tolerance amo ... Full text Open Access Link to item Cite

Relative Importance of Mode of Administration in Treatment Preferences among Plaque Psoriasis Patients in the United States.

Journal Article J Health Econ Outcomes Res · 2017 Background: Some aspects of psoriasis treatments can negatively influence patients' quality of life. There is evidence from previous preference-elicitation research in psoriasis that administration characteristics are at least as important as treatment out ... Full text Link to item Cite

What are people willing to pay for whole-genome sequencing information, and who decides what they receive?

Journal Article Genet Med · December 2016 PURPOSE: Whole-genome sequencing (WGS) can be used as a powerful diagnostic tool as well as for screening, but it may lead to anxiety, unnecessary testing, and overtreatment. Current guidelines suggest reporting clinically actionable secondary findings whe ... Full text Link to item Cite

Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons' Referrals.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: This study aimed to assess the influence of disease- and patient-related factors on surgeons' decisions to refer patients with early-stage breast cancer (EBC) for neoadjuvant systemic therapy (NST). METHODS: An online survey of United States su ... Full text Link to item Cite

Patient, Caregiver, and Nurse Preferences for Treatments for Bone Metastases from Solid Tumors.

Journal Article Patient · August 2016 BACKGROUND: Bone-targeted agents (BTAs) used for the prevention of skeletal-related events (SREs) associated with metastatic bone disease possess different attributes that factor into treatment decisions. OBJECTIVE: The aim of this study was to evaluate pr ... Full text Link to item Cite

Statistical Methods for the Analysis of Discrete Choice Experiments: A Report of the ISPOR Conjoint Analysis Good Research Practices Task Force.

Journal Article Value Health · June 2016 Featured Publication Conjoint analysis is a stated-preference survey method that can be used to elicit responses that reveal preferences, priorities, and the relative importance of individual features associated with health care interventions or services. Conjoint analysis met ... Full text Link to item Cite

Incorporating patient-preference evidence into regulatory decision making.

Journal Article Surg Endosc · October 2015 Featured Publication BACKGROUND: Patients have a unique role in deciding what treatments should be available for them and regulatory agencies should take their preferences into account when making treatment approval decisions. This is the first study designed to obtain quantit ... Full text Link to item Cite

Physician preferences for bone metastasis drug therapy in Canada.

Journal Article Curr Oncol · October 2015 BACKGROUND: Currently in Canada, several bone-targeted agents (btas) with varying characteristics are available for the prevention of skeletal-related events (sres) in patients with bone metastasis secondary to solid tumours. In the present study, we evalu ... Full text Link to item Cite

Patients’ and physicians’ preferences for approaches to bone metastases treatment in Turkey

Journal Article UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi · September 19, 2015 Bone metastases and associated skeletal-related events (SREs) are common in patients with advanced breast, lung, and prostate cancer. Bone-targeted agents (BTAs) are available for the treatment of bone metastases, but little is known about patients’ and ph ... Full text Cite

Estimating conditional certainty equivalents using choice-experiment data

Journal Article Journal of Choice Modelling · June 1, 2015 Featured Publication Expected-utility theory is embraced by some researchers because of its theoretical and empirical tractability, although empirical testing has exposed systematic behavioral inconsistencies that violate the axiom of independence in the theory. In particular, ... Full text Cite

Comparing Patient and Physician Risk Tolerance for Bleeding Events Associated with Anticoagulants in Atrial Fibrillation-evidence from the United States and Japan.

Journal Article Value Health Reg Issues · May 2015 OBJECTIVES: Atrial fibrillation (AF) is a factor in the development of thrombi that can lead to ischemic strokes. Anticoagulants are crucial in preventing strokes among patients with AF but are associated with bleeding risks. Recent studies have shown that ... Full text Link to item Cite

Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments.

Journal Article J Thyroid Res · 2015 Background. The aims of this study were to assess patients' preferences to wait or start systemic treatment and understand how patients would make tradeoffs between certain severe adverse events (AEs) and additional months of progression-free survival (PFS ... Full text Link to item Cite

Physicians' preferences for bone metastases drug therapy in the United States.

Journal Article Value Health · January 2015 OBJECTIVE: Several characteristics of bone-targeted agents are considered when making treatment decisions. This study evaluated physicians' therapy preferences for preventing skeletal-related events (SREs) in patients with bone metastases secondary to soli ... Full text Link to item Cite

Japanese Patients' and Physicians' Preferences for Anticoagulant Use in Atrial Fibrillation: Results from a Discrete-choice Experiment.

Journal Article J Health Econ Outcomes Res · 2015 Background: Anticoagulants are recommended for stroke prevention in patients with atrial fibrillation (AF), but are associated with an increased risk of bleeding; therefore, physicians face benefit-risk tradeoffs when prescribing anticoagulants to AF patie ... Full text Link to item Cite

Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening.

Journal Article Value Health · December 2014 BACKGROUND: The value of the information that genetic testing services provide can be questioned for insurance-based health systems. The results of genetic tests oftentimes may not lead to well-defined clinical interventions; however, Lynch syndrome, a gen ... Full text Link to item Cite

Patient preferences for treatments to delay bone metastases.

Journal Article Prostate · November 2014 BACKGROUND: Most patients with advanced prostate cancer (PCa) develop bone metastases (BM) and present with bone complications like fracture. Bone-targeted agents that prevent metastasis-induced bone complications can cause adverse events. Understanding ho ... Full text Link to item Cite

Patients' willingness to trade off between the duration and frequency of rheumatoid arthritis treatments.

Journal Article Arthritis Care Res (Hoboken) · July 2014 OBJECTIVE: Biologic treatments for rheumatoid arthritis (RA) vary widely in both the time required to administer treatment and treatment frequency. This study aimed to quantify the rate at which RA patients are willing to trade off between the time require ... Full text Link to item Cite

Benefit-risk trade-off preferences for severe chronic hand eczema treatments

Conference JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY · May 1, 2014 Link to item Cite

Preferences for treatment to delay bone metastases (BM) in patients with castration-resistant prostate cancer (CRPC) at high risk of developing BM.

Conference Journal of Clinical Oncology · February 1, 2014 117 Background: Limited treatments are available for patients with non-metastatic CRPC. Prophylactic treatment may be associated with adverse events (AE). We evaluated patient preferences for a medication delaying bone metastases ... Full text Cite

Physician preferences for extra-glycemic effects of type 2 diabetes treatments.

Journal Article Diabetes Ther · December 2013 INTRODUCTION: The purpose of this study was to quantify United States (US) and United Kingdom (UK) physicians' preferences for attributes of type 2 diabetes treatments. METHODS: Samples of general practitioners (GPs) and endocrinologists in the US (n = 204 ... Full text Link to item Cite

Evaluating migraineurs' preferences for migraine treatment outcomes using a choice experiment.

Journal Article Headache · 2013 Featured Publication OBJECTIVE: The impact of migraines on patients is commonly divided between the level of impairment associated with headache symptoms (headache phase) and the quality-of-life effects immediately following the headache (post-headache phase). Evaluations of m ... Full text Link to item Cite

Effect of pill burden on dosing preferences, willingness to pay, and likely adherence among patients with type 2 diabetes.

Journal Article Patient Prefer Adherence · 2013 PURPOSE: To quantify willingness-to-pay (WTP) for reducing pill burden and dosing frequency among patients with type 2 diabetes mellitus (T2DM), and to examine the effect of dosing frequency and pill burden on likely medication adherence. PATIENTS AND METH ... Full text Link to item Cite

Patient preferences for biologic agents in rheumatoid arthritis: a discrete-choice experiment.

Journal Article Value Health · 2013 OBJECTIVES: To assess patients' preferences for rheumatoid-arthritis treatments with biologic agents using a discrete-choice experiment. METHODS: A discrete-choice experiment was conducted with adult rheumatoid-arthritis patients who had never been treated ... Full text Link to item Cite

Consumer preferences for household water treatment products in Andhra Pradesh, India.

Journal Article Soc Sci Med · August 2012 Over 5 billion people worldwide are exposed to unsafe water. Given the obstacles to ensuring sustainable improvements in water supply infrastructure and the unhygienic handling of water after collection, household water treatment and storage (HWTS) product ... Full text Link to item Cite

[Idiophatic inflammatory myophaties: its asociation with liver disorders].

Journal Article Rev Fac Cien Med Univ Nac Cordoba · 2012 UNLABELLED: The aspartate aminotransferase (SGOT) and alanine aminotransferase (SGPT) are sensitive indicators of liver damage. While the TSGOT is also found in other organs, the SGPT is considered an enzyme specific liver. However, some authors state that ... Link to item Cite

Effects of interactions between solids and surfactants on the tribological properties of water-based drilling fluids

Conference Colloids and Surfaces A: Physicochemical and Engineering Aspects · November 2011 Full text Cite

Healthy-days time equivalents for outcomes of acute rotavirus infections.

Journal Article Vaccine · October 19, 2011 Rotavirus is the most common cause of severe gastroenteritis in infants and young children worldwide. Health-state utility measures used in economic evaluations of rotavirus vaccines do not reflect differences between mild and severe symptoms of rotavirus ... Full text Link to item Cite

The value to patients of reducing lesion severity in plaque psoriasis.

Journal Article J Dermatolog Treat · October 2011 Plaque psoriasis is associated with significant psychosocial, quality-of-life, and economic burden. The objective of this study was to quantify the value to patients of reducing the severity and size of plaque psoriasis lesions. Subjects included individua ... Full text Link to item Cite

Patient preferences for reducing toxicities of treatments for gastrointestinal stromal tumor (GIST).

Journal Article Patient Prefer Adherence · 2011 PURPOSE: To quantify gastrointestinal stromal tumor (GIST) patients' preferences for reducing treatment toxicities and the likely effect of toxicities on patients' stated adherence. METHODS: English-speaking members of the Life Raft Group, a GIST patient a ... Full text Link to item Cite

PSY48 THE VALUE TO PATIENTS OF TREATING PLAQUE PSORIASIS

Journal Article Value in Health · May 2010 Full text Cite

Do CVM welfare estimates suffer from on-site sampling bias? A comparison of on-site and household visitor surveys

Journal Article Agricultural and Resource Economics Review · January 1, 2010 The problem of endogenous stratification associated with on-site sampling has been overlooked in the Contingent Valuation Method (CVM). We find that using on-site samples of visitors overstates visitor willingness to pay (WTP) estimates relative to a house ... Full text Cite

A Joint Estimation Method to Combine Dichotomous Choice CVM Models with Count Data TCM Models Corrected for Truncation and Endogenous Stratification

Journal Article · August 2008 We update the joint estimation of revealed and stated preference data of previously published research to allow for joint estimation of the Travel Cost Method (TCM) portion using count data models. The TCM estimation also corrects for truncation and e ... Cite

Spatial limits of the travel cost model revisited:: Island effects

Journal Article JOURNAL OF AGRICULTURAL AND RESOURCE ECONOMICS · 2007 Cite