Scholars@Duke
Judd Wendell Moul

Judd Wendell Moul

James H. Semans, M.D. Distinguished Professor of Urologic Surgery, in the School of Medicine
Urology
judd.moul@duke.edu
Box 3707 Med Ctr, Durham, NC 27710
1562 Blue Zone, Duke South, Durham, NC 27710
Office hours

Featured Works

A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes.

Journal article Eur Urol · April 2012 Featured Publication CONTEXT: The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostate ... Full text Link to item Cite

The number of high-risk factors and the risk of prostate cancer-specific mortality after brachytherapy: implications for treatment selection.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To determine whether an increasing number of high-risk factors is associated with higher prostate cancer-specific mortality (PCSM) among men treated with brachytherapy (BT)-based treatment, and whether supplemental therapy has an impact on this ri ... Full text Link to item Cite

Pretreatment expectations of patients undergoing robotic assisted laparoscopic or open retropubic radical prostatectomy.

Journal article J Urol · March 2012 Featured Publication PURPOSE: We previously found that patients undergoing robotic assisted laparoscopic radical prostatectomy vs radical retropubic prostatectomy had a higher likelihood of not being satisfied, independent of side effect profile. We hypothesized that different ... Full text Link to item Cite

Emerging treatment options for patients with castration-resistant prostate cancer.

Journal article Prostate · February 2012 Featured Publication BACKGROUND: Most prostate cancer-related deaths occur in patients with castration-resistant prostate cancer (CRPC). Recent preclinical and clinical studies have identified intracellular signaling pathways and changes in the tumor and bone microenvironment ... Full text Link to item Cite

Characteristics of baseline PSA and PSA velocity in young men without prostate cancer: Racial differences.

Journal article Prostate · February 1, 2012 Featured Publication BACKGROUND: Baseline prostate specific antigen (PSA) and PSA velocity used to stratify subsequent prostate cancer risk in young men may not directly applicable to all populations. We sought to compare the baseline PSA and PSA velocity among ethnic groups. ... Full text Link to item Cite

Biopsy accuracy in identifying unilateral prostate cancer depends on prostate weight.

Journal article Urol Oncol · 2012 Featured Publication OBJECTIVE: To evaluate the association between prostate weight and the diagnostic performance of routine biopsy schemes in detecting unilateral prostate cancer (PCa) that may be amenable to focal therapy. METHODS AND MATERIALS: Retrospective analysis of pa ... Full text Link to item Cite

Quality of life associated with treatment of castration-resistant prostate cancer: a review of the literature.

Journal article Cancer Invest · January 2012 Featured Publication The development of new therapies for castration-resistant prostate cancer (CRPC) has increasingly focused on improving patient quality of life, mainly because of limited survival gains and continuing high morbidity burden from disease progression or the ad ... Full text Link to item Cite

Baseline prostate-specific antigen testing at a young age.

Journal article Eur Urol · January 2012 Featured Publication CONTEXT: Prostate cancer screening is highly controversial, including the age to begin prostate-specific antigen (PSA) testing. Several studies have evaluated the usefulness of baseline PSA measurements at a young age. OBJECTIVE: Review the literature on b ... Full text Link to item Cite

Utilization trends at a multidisciplinary prostate cancer clinic: initial 5-year experience from the Duke Prostate Center.

Journal article J Urol · January 2012 Featured Publication PURPOSE: The multidisciplinary approach is becoming increasingly encouraged but little is known about the multidisciplinary experience compared to routine care. For patients with prostate cancer the goal is to provide evaluations by urologists, medical and ... Full text Link to item Cite

Predictive value of digital rectal examination for prostate cancer detection is modified by obesity.

Journal article Prostate Cancer Prostatic Dis · December 2011 Featured Publication The American Cancer Society's updated screening guidelines for prostate cancer (CaP) render digital rectal examination (DRE) optional. We investigated the impact of DRE on CaP detection among obese men. Data from 2794 men undergoing initial prostate biopsy ... Full text Link to item Cite

Prostate-specific antigen 1.5-4.0 ng/mL: a diagnostic challenge and danger zone.

Journal article BJU Int · December 2011 Featured Publication UNLABELLED: What's known on the subject? and What does the study add? Large population screening trials like the ERSPC, PCPT and PLCO have noted that men with seemingly low PSA (even as low as 0.5 ng/dL) still can have prostate cancer. Despite these findin ... Full text Link to item Cite

Traditional approaches to androgen deprivation therapy.

Journal article Urology · November 2011 Featured Publication For most of the past 25 years, 1 of the favored approaches to treating prostate cancer has been the suppression of circulating testosterone with luteinizing hormone-releasing hormone (LHRH) agonists. LHRH agonists produce a downregulation of LHRH receptors ... Full text Link to item Cite

New data, new paradigms for treating prostate cancer patients--VI: novel hormonal therapy approaches.

Journal article Urology · November 2011 Featured Publication Until the 1980s, testosterone suppression for men with advanced prostate cancer was managed surgically, with bilateral orchiectomy, or medically, with diethylstilbestrol, a drug that was associated with a problematic side effect profile. Beginning in the m ... Full text Link to item Cite

Salvage radiation in men after prostate-specific antigen failure and the risk of death.

Journal article Cancer · September 1, 2011 Featured Publication BACKGROUND: A survival benefit has been observed with salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in men with rapid rises in PSA doubling time (DT, < 6 months). Whether such a benefit exits in ... Full text Link to item Cite

Risk of death from prostate cancer after radical prostatectomy or brachytherapy in men with low or intermediate risk disease.

Journal article J Urol · July 2011 Featured Publication PURPOSE: Radical prostatectomy and brachytherapy are widely used treatments for favorable risk prostate cancer. We estimated the risk of prostate cancer specific mortality following radical prostatectomy or brachytherapy in men with low or intermediate ris ... Full text Link to item Cite

Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.

Journal article BJU Int · July 2011 Featured Publication OBJECTIVE: • To evaluate weather prostate-specific antigen (PSA) velocity could be used to stratify patients at risk of death from prostate cancer (PCa) and be useful in aiding decision making regarding PSA screening in elderly men, as previous studies hav ... Full text Link to item Cite

Effects of family history and genetic polymorphism on the cost-effectiveness of chemoprevention with finasteride for prostate cancer.

Journal article J Urol · March 2011 Featured Publication PURPOSE: Improvement in the cost-effectiveness of chemoprevention for prostate cancer could be realized through the identification of patients at higher risk. We estimated the cost-effectiveness of prostate cancer chemoprevention across risk groups defined ... Full text Link to item Cite

Contemporary radical prostatectomy.

Journal article Prostate Cancer · 2011 Featured Publication Purpose. Patients diagnosed with clinically localized prostate cancer have more surgical treatment options than in the past. This paper focuses on the procedures' oncological or functional outcomes and perioperative morbidities of radical retropubic prosta ... Full text Open Access Link to item Cite

Pathological T2 sub-divisions as a prognostic factor in the biochemical recurrence of prostate cancer.

Journal article BJU Int · December 2010 Featured Publication OBJECTIVE: To determine the adequacy of T2 prostate cancer (PCa) sub-staging as an independent Predictor of biochemical disease-free survival (bDFS) after radical prostatectomy. MATERIALS AND METHODS: The Duke Prostate Center database was queried for patie ... Full text Link to item Cite

Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death.

Journal article BJU Int · December 2010 Featured Publication OBJECTIVE: To investigate whether salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure can provide the same result as adjuvant RT, which decreases the risk of all-cause mortality (ACM) for men with positive margins (R1), or extra-caps ... Full text Link to item Cite

Baseline PSA as a predictor of prostate cancer-specific mortality over the past 2 decades: Duke University experience.

Journal article Cancer · October 15, 2010 Featured Publication BACKGROUND: A diagnosis of prostate cancer is not often predictive of death from prostate cancer because of competing causes of mortality. Identification of the risk of death from prostate cancer and death from all causes using information available at the ... Full text Link to item Cite

Assessment of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors.

Journal article Pathol Int · October 2010 Featured Publication The objective of this study was to assess the incidence of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors (less than 0.5 cc) after radical prostatectomy (RP). Blood samples were collected from 64 RP patients to assess the ... Full text Link to item Cite

Obese African-Americans with prostate cancer (T1c and a prostate-specific antigen, PSA, level of <10 ng/mL) have higher-risk pathological features and a greater risk of PSA recurrence than non-African-Americans.

Journal article BJU Int · October 2010 Featured Publication OBJECTIVE: to analyse the relationship between African American (AA) race and obesity in men with prostate cancer. PATIENTS AND METHODS: in all, 4196 patients who underwent radical prostatectomy from 1988 to 2008 were identified in the Duke Prostate Center ... Full text Link to item Cite

Predicting non-organ-confined prostate cancer in men diagnosed after 2000.

Journal article Prostate Cancer Prostatic Dis · September 2010 Featured Publication The objective of this study was to preoperatively predict non-organ-confined disease in patients considering radical prostatectomy. To account for the stage migration seen in prostate cancer, we included only those patients who underwent prostatectomy afte ... Full text Link to item Cite

Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology.

Journal article BJU Int · August 2010 Featured Publication Prostate cancer is the most prevalent cancer in men and predominantly affects older men (aged >or=70 years). The median age at diagnosis is 68 years; overall, two-thirds of prostate cancer-related deaths occur in men aged >or=75 years. With the exponential ... Full text Open Access Link to item Cite

Re-calibration and external validation of an existing nomogram to predict aggressive recurrences after radical prostatectomy.

Journal article BJU Int · June 2010 Featured Publication OBJECTIVE: To re-calibrate the previously published Duke Prostate Center (DPC) nomogram for the prediction of biochemical recurrence (BCR) after radical prostatectomy (RP) to not only predict overall BCR but also the clinically more relevant endpoint of an ... Full text Link to item Cite

Prostate cancer: an evolving paradigm.

Journal article J Endourol · May 2010 Featured Publication Since at least the early 1990s, stage and risk migration have been seen in patients with prostate cancer, likely corresponding to the institution of prostate specific antigen (PSA) screening in health systems. Preoperative risk factors, including PSA level ... Full text Open Access Link to item Cite

Public survey and survival data do not support recommendations to discontinue prostate-specific antigen screening in men at age 75.

Journal article Urology · May 2010 Featured Publication OBJECTIVES: To evaluate the US Preventative Services Task Force (USPSTF) recommendation to discontinue prostate-specific antigen (PSA) screening at age 75. METHODS: Public survey: A cohort of 340 patients was surveyed at our PSA screening clinic and strati ... Full text Link to item Cite

The effect of race on the discriminatory accuracy of models to predict biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases.

Journal article Prostate Cancer Prostatic Dis · March 2010 Featured Publication To evaluate whether race modifies the accuracy of nomograms to predict biochemical recurrence (BCR) after radical prostatectomy among subjects from the Shared Equal Access Regional Cancer Hospital (SEARCH) and Duke Prostate Center (DPC) databases. Retrospe ... Full text Link to item Cite

Initial prostate specific antigen 1.5 ng/ml or greater in men 50 years old or younger predicts higher prostate cancer risk.

Journal article J Urol · March 2010 Featured Publication PURPOSE: Studies show that initial prostate specific antigen higher than the median in young men predicts a subsequent higher risk of prostate cancer. To our knowledge this relationship has not been studied in patients stratified by race. MATERIALS AND MET ... Full text Link to item Cite

Tumor percent involvement predicts prostate specific antigen recurrence after radical prostatectomy only in men with smaller prostate.

Journal article J Urol · March 2010 Featured Publication PURPOSE: We determined the predictive power of tumor percent involvement on prostate specific antigen recurrence in patients when stratified by prostate weight. MATERIALS AND METHODS: Data on 3,057 patients who underwent radical prostatectomy between 1988 ... Full text Link to item Cite

Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?

Journal article Urology · February 2010 Featured Publication OBJECTIVES: To compare the effects of tumor volume (TV), tumor percentage involvement (TPI), and prostate volume (PV) on prostate-specific antigen (PSA) recurrence (PSAR) after radical prostatectomy (RP). METHODS: A cohort of 3528 patients receiving RP bet ... Full text Link to item Cite

Background for the proposal of SIOG guidelines for the management of prostate cancer in senior adults.

Journal article Crit Rev Oncol Hematol · January 2010 Featured Publication BACKGROUND: The incidence of prostate cancer increases with age, with a median age at diagnosis of 68 years. Owing to increased life expectancy, the management of prostate cancer in senior adult men (i.e., aged 70 years or older) represents an important pu ... Full text Link to item Cite

Changes in Gleason score grading and their effect in predicting outcome after radical prostatectomy.

Journal article Urology · November 2009 Featured Publication OBJECTIVES: To compare Gleason scores (GS) originally assigned in the mid 1990s with the current pathologic evaluation of the same prostatectomy slides, and to assess the GS migration effect on outcome in patients undergoing surgical treatment of prostate ... Full text Link to item Cite

Men older than 70 years have higher risk prostate cancer and poorer survival in the early and late prostate specific antigen eras.

Journal article J Urol · November 2009 Featured Publication PURPOSE: We clarified whether men older than 70 years have a higher risk of prostate cancer and poorer survival in the early and late prostate specific antigen eras. MATERIALS AND METHODS: A cohort of 4,561 men who underwent radical prostatectomy were stra ... Full text Link to item Cite

Robot-assisted laparoscopic prostatectomy is not associated with early postoperative radiation therapy.

Journal article BJU Int · November 2009 Featured Publication OBJECTIVE: To compare open radical prostatectomy (RP) and robot-assisted laparoscopic prostatectomy (RALP), and to determine whether RALP is associated with a higher risk of features that determine recommendations for postoperative radiation therapy (RT). ... Full text Link to item Cite

Delayed prostate-specific antigen recurrence after radical prostatectomy: how to identify and what are their clinical outcomes?

Journal article Urology · September 2009 Featured Publication OBJECTIVES: To identify factors that predict delayed (> 5 years) prostate-specific antigen recurrence (PSAR) after radical prostatectomy (RP) and to analyze the associated clinical outcomes. METHODS: A cohort of 4561 men who underwent RP between 1988 and 2 ... Full text Link to item Cite

Effect of age and pathologic Gleason score on PSA recurrence: analysis of 2911 patients undergoing radical prostatectomy.

Journal article Urology · September 2009 Featured Publication OBJECTIVES: To clarify the relationship between age and pathologic Gleason score and their effect on prostate-specific antigen recurrence (PSAR). METHODS: The data from a cohort of 2911 men who had undergone radical prostatectomy from 1988 to 2006 were ret ... Full text Link to item Cite

Body mass index and prostate specific antigen as predictors of adverse pathology and biochemical recurrence after prostatectomy.

Journal article J Urol · August 2009 Featured Publication PURPOSE: Preoperative prostate specific antigen is widely used to predict unfavorable pathological features and biochemical relapse after radical prostatectomy. Recent reports that hemodilution may be responsible for lower prostate specific antigen in obes ... Full text Link to item Cite

Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up.

Journal article BJU Int · August 2009 Featured Publication OBJECTIVE: To compare the efficacy and tolerability of peripheral androgen blockade using combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for treating biochemical relapse after the definitive management of prostate adenocarci ... Full text Link to item Cite

A retrospective comparison of anesthetic management of robot-assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy.

Journal article J Clin Anesth · August 2009 Featured Publication STUDY OBJECTIVE: To compare anesthetic management and postoperative outcomes in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP) and radical retropubic prostatectomy (RRP) with general anesthesia. DESIGN: Retrospective database ... Full text Link to item Cite

Factors predicting prostatic biopsy Gleason sum under grading.

Journal article J Urol · July 2009 Featured Publication PURPOSE: We determined clinical factors affecting the under grading of biopsy Gleason sum compared with prostatectomy pathology and developed a model predicting the probability of under grading. MATERIALS AND METHODS: We analyzed a cohort of 1,701 patients ... Full text Link to item Cite

Lidocaine patch for postoperative analgesia after radical retropubic prostatectomy.

Journal article Anesth Analg · June 2009 Featured Publication In a prospective, double-blind, placebo-controlled study, patients undergoing radical retropubic prostatectomy under general anesthesia were randomly assigned to receive a lidocaine patch or placebo applied on each side of the wound at the end of surgery. ... Full text Link to item Cite

Patient selection for hemiablative focal therapy of prostate cancer: variables predictive of tumor unilaterality based upon radical prostatectomy.

Journal article Cancer · May 15, 2009 Featured Publication BACKGROUND: The application of focal therapy for low-risk prostate cancer (PCa) depended on appropriate patient selection. No definitive criteria existed to characterize patients who may potentially benefit from an organ-sparing approach. We evaluated pret ... Full text Link to item Cite

Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection.

Journal article Technol Cancer Res Treat · April 2009 Featured Publication The 3-D transrectal ultrasound (TRUS)-guided prostate biopsy system is a novel device that allows precise needle placement in a template fashion. We evaluate its utility for prostate cancer (PCa) detection. A retrospective analysis was performed evaluating ... Full text Link to item Cite

Predicting prostate cancer mortality among men with intermediate to high-risk disease and multiple unfavorable risk factors.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2009 Featured Publication PURPOSE: To determine whether the number of unfavorable risk factors could be used to predict the risk of prostate cancer-specific mortality (PCSM) among men with intermediate- to high-risk prostate cancer. METHODS AND MATERIALS: We studied 1,063 men who u ... Full text Link to item Cite

Prostate cancer: the new landscape.

Journal article Curr Opin Urol · March 2009 Featured Publication PURPOSE OF REVIEW: This review highlights current features of the changing landscape of the US population with newly diagnosed prostate cancer and discusses new treatment options utilizing noninvasive or minimally invasive management. RECENT FINDINGS: Rece ... Full text Link to item Cite

Innovations in urology from military medicine.

Other Urol Oncol · 2009 Featured Publication Full text Link to item Cite

Post-radical prostatectomy management options for positive surgical margins: argument for observation.

Journal article Urol Oncol · 2009 Featured Publication The screening zeal for prostate cancer in the PSA era resulted in and continues to produce an unprecedented number of men who have clinically localized prostate cancer seeking radical prostatectomy. Even before the advent of robotic laparoscopic-assisted r ... Full text Link to item Cite

Report from Durham.

Other Prostate Cancer Prostatic Dis · 2009 Featured Publication Full text Link to item Cite

Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database.

Journal article Prostate Cancer Prostatic Dis · 2009 Featured Publication Obesity is associated with increased risk of positive surgical margins and prostate specific antigen (PSA) recurrence among men undergoing radical prostatectomy. To what degree positive margins contribute to poorer outcome is unclear. Thus, we sought to ex ... Full text Link to item Cite

Are we overtreating prostate cancer?

Other J Urol · December 2008 Featured Publication Full text Link to item Cite

Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Journal article Cancer Epidemiol Biomarkers Prev · December 2008 Featured Publication BACKGROUND: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies ... Full text Link to item Cite

Defining potency: a comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite.

Journal article Cancer · November 15, 2008 Featured Publication BACKGROUND: Both the 5-item short version of the International Index of Erectile Function (IIEF-5) and the Expanded Prostate Cancer Index Composite (EPIC) have been used to assess erectile function. In this study, the authors compared various definitions o ... Full text Link to item Cite

Significant discrepancies between diagnostic and pathologic Gleason sums in prostate cancer: the predictive role of age and prostate-specific antigen.

Journal article Urology · October 2008 Featured Publication OBJECTIVES: To assess the discrepancies between diagnostic and pathologic Gleason sums and the predictive role of age and prostate-specific antigen (PSA) level on Gleason sum discrepancies. METHODS: A total of 2963 patients receiving radical prostatectomy ... Full text Link to item Cite

Pathologic stage T2a and T2b prostate cancer in the recent prostate-specific antigen era: implications for unilateral ablative therapy.

Journal article Prostate · September 15, 2008 Featured Publication BACKGROUND: Early detection of small volume prostate cancer (PCa) has led to the concept of focal therapy to treat in an organ-sparing manner. We evaluated trends in pathologic staging among patients with localized PCa undergoing radical prostatectomy (RP) ... Full text Link to item Cite

Prostate-specific antigen screening among young men in the United States.

Journal article Cancer · September 15, 2008 Featured Publication BACKGROUND: Disagreement exists on the use of prostate-specific antigen (PSA) tests for cancer-risk stratification in young men in the United States. Little is known about the use of PSA testing in these men. To understand policy implications of risk strat ... Full text Link to item Cite

Transdermal nicotine for analgesia after radical retropubic prostatectomy.

Journal article Anesth Analg · September 2008 Featured Publication BACKGROUND: Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients ... Full text Link to item Cite

Obesity and oncological outcome after radical prostatectomy: impact of prostate-specific antigen-based prostate cancer screening: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases.

Journal article BJU Int · September 2008 Featured Publication OBJECTIVE: To indirectly test the hypothesis that prostate-specific antigen (PSA)-based screening is biased against obese men due to haemodilution of PSA, and thus results in delayed diagnosis and poorer outcome beyond the biological link between obesity a ... Full text Link to item Cite

Percent tumor involvement and risk of biochemical progression after radical prostatectomy.

Journal article J Urol · August 2008 Featured Publication PURPOSE: Percent tumor involvement has been associated with biochemical progression in organ confined disease, although its role in predicting outcome in men with more advanced disease pathology is unclear. We hypothesized percent tumor involvement may be ... Full text Link to item Cite

A decision aid for teaching limitations of prostate cancer screening.

Journal article J Natl Black Nurses Assoc · July 2008 Featured Publication There is minimal research regarding men's knowledge of the limitations of prostate cancer screening. This study measured knowledge of prostate cancer screening based on exposure to one of two decision aids that were related to prostate cancer screening (en ... Link to item Cite

Comparison of prostate-specific antigen recurrence-free survival in a contemporary cohort of patients undergoing either radical retropubic or robot-assisted laparoscopic radical prostatectomy.

Journal article BJU Int · July 2008 Featured Publication OBJECTIVES: To compare the prostate-specific antigen (PSA) recurrence (PSAR) rates in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP) or radical retropubic prostatectomy (RRP). PATIENTS AND METHODS: Data from 797 consecutive pa ... Full text Link to item Cite

Can prostate-specific antigen and prostate-specific antigen velocity be used for prostate cancer screening in men older than 70 years?

Journal article Urology · June 2008 Featured Publication OBJECTIVES: We evaluated the lower threshold of prostate-specific antigen (PSA) and prostate-specific antigen velocity (PSAV) in a population of men over 70 years of age. METHODS: Between January 1988 and December 2005, 4038 men over 70 years of age includ ... Full text Link to item Cite

Early versus delayed hormonal therapy for prostate specific antigen only recurrence of prostate cancer after radical prostatectomy.

Journal article J Urol · May 2008 Featured Publication PURPOSE: Hormonal therapy (HT) is the current mainstay of systemic treatment for prostate specific antigen (PSA) only recurrence (PSAR), however, there is virtually no published literature comparing HT to observation in the clinical setting. The goal of th ... Full text Link to item Cite

Trainees do not negatively impact the institutional learning curve for robotic prostatectomy as characterized by operative time, estimated blood loss, and positive surgical margin rate.

Journal article Urology · April 2008 Featured Publication OBJECTIVES: We evaluated the learning curves and perioperative outcomes of an experienced laparoscopic surgeon and his trainees to assess our structured teaching program. METHODS: We retrieved 383 patients undergoing robot-assisted laparoscopic prostatecto ... Full text Link to item Cite

Significance of tertiary Gleason pattern 5 in Gleason score 7 radical prostatectomy specimens.

Journal article J Urol · February 2008 Featured Publication PURPOSE: The Gleason grading system in reporting prostate cancer accounts for the primary and secondary Gleason pattern. The clinical significance of a higher tertiary (third most prevalent) grade is largely unrecognized. MATERIALS AND METHODS: Radical pro ... Full text Link to item Cite

Report from Durham.

Other Prostate Cancer Prostatic Dis · 2008 Featured Publication Full text Link to item Cite

Report from Durham.

Other Prostate Cancer Prostatic Dis · 2008 Featured Publication Full text Link to item Cite

Race and prostate weight as independent predictors for biochemical recurrence after radical prostatectomy.

Journal article Prostate Cancer Prostatic Dis · 2008 Featured Publication We hypothesized that factors beyond pathological stage, grade, PSA and margin status would be important predictors of biochemical recurrence (BCR) after radical prostatectomy (RP). A cohort of 3194 patients who underwent RP between 1988 and 2007 and who ha ... Full text Link to item Cite

Prostate cancer in the Baby Boomer generation: results from CaPSURE.

Journal article Urology · December 2007 Featured Publication OBJECTIVES: Baby Boomers (those born in 1946 to 1964) are thought to place a high value on quality of life, and have a higher propensity to consume healthcare services than previous generations. We sought to characterize prostate cancer (CaP) presentation ... Full text Link to item Cite

A single-institution comparison between radical perineal and radical retropubic prostatectomy on perioperative and pathological outcomes for obese men: an analysis of the Duke Prostate Center database.

Journal article Urology · December 2007 Featured Publication OBJECTIVES: To examine the association between body mass index (BMI) and operative time, estimated blood loss (EBL), and adverse pathologic features in patients undergoing either radical perineal prostatectomy (RPP) or radical retropubic prostatectomy (RRP ... Full text Link to item Cite

Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy.

Journal article Urology · December 2007 Featured Publication OBJECTIVES: To evaluate biologic behaviors of unilateral cancers compared with bilateral cancers on prostate-specific antigen (PSA) recurrence after radical prostatectomy. METHODS: Analysis included demographic, clinical, and pathologic parameters of 1184 ... Full text Link to item Cite

Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer.

Journal article JAMA · November 21, 2007 Featured Publication CONTEXT: Recent studies have suggested that obese men have lower serum prostate-specific antigen (PSA) concentrations than nonobese men. Because men with higher body mass index (BMI) have greater circulating plasma volumes, lower PSA concentrations among o ... Full text Link to item Cite

Rising PSA in nonmetastatic prostate cancer.

Journal article Oncology (Williston Park) · November 2007 Featured Publication Rising prostate-specific antigen (PSA) in nonmetastatic prostate cancer occurs in two main clinical settings: (1) rising PSA to signal failed initial local therapy and (2) rising PSA in the setting of early hormone-refractory prostate cancer prior to docum ... Link to item Cite

Open radical retropubic prostatectomy 2007: the true minimally invasive surgery for localized prostate cancer?

Journal article Expert Rev Anticancer Ther · September 2007 Featured Publication The introduction of robotic laparoscopic assisted prostatectomy at our institution and nationwide has been a great advancement and has caused us to focus and fine-tune our goal for improvements in prostate cancer outcomes whether the patient elects for rob ... Full text Link to item Cite

Prostate cancer laterality as a rationale of focal ablative therapy for the treatment of clinically localized prostate cancer.

Journal article Cancer · August 15, 2007 Featured Publication BACKGROUND: Early detection of small-volume prostate cancer (PCa) has led to the concept of focal therapy to treat PCa as an organ-sparing, minimally invasive procedure. The authors sought to determine the frequency of unilateral cancers in the contemporar ... Full text Link to item Cite

Erectile function outcome reporting after clinically localized prostate cancer treatment.

Journal article J Urol · August 2007 Featured Publication PURPOSE: In conjunction with the assignment to update the Guidelines for Management of Clinically Localized Prostate Cancer, the American Urological Association Prostate Cancer Guideline Update Panel performed a side analysis of the reporting of erectile f ... Full text Link to item Cite

Prostate cancer-specific mortality after radical prostatectomy or external beam radiation therapy in men with 1 or more high-risk factors.

Journal article Cancer · July 1, 2007 Featured Publication BACKGROUND: Estimates of prostate cancer-specific mortality (PCSM) were determined after radical prostatectomy (RP) or radiation therapy (RT) in men with >or=1 high-risk factors. METHODS: The study cohort comprised 948 men who underwent RP (N = 660) or RT ... Full text Link to item Cite

Prostate specific antigen recurrence after definitive therapy.

Journal article J Urol · June 2007 Featured Publication PURPOSE: We estimate that approximately 70,000 men yearly have prostate specific antigen-only recurrence after failed definitive therapy. The ideal salvage therapy for these men is not clear. Treatment must be individualized based on the patient risk of pr ... Full text Link to item Cite

Novel techniques for the treatment of localized prostate cancer: evidence of efficacy?

Journal article Curr Urol Rep · May 2007 Featured Publication Radical retropubic prostatectomy and radiation therapy remain the mainstay of treatment for localized prostate cancer. However, with the advent of the Internet, more patients are arriving in physicians' offices questioning novel techniques for their treatm ... Full text Link to item Cite

Timely diagnosis of testicular cancer.

Journal article Urol Clin North Am · May 2007 Featured Publication Early detection of testicular tumors has been touted as beneficial for more than 100 years. In earlier eras, early detection was virtually the only way to improve outcomes. According to statistics that have been tracked in the literature, however, the dela ... Full text Link to item Cite

The role of early adopter bias for new technologies in robot assisted laparoscopic prostatectomy.

Journal article J Urol · April 2007 Featured Publication PURPOSE: We determined the potential influence of an early adopter bias in patients undergoing robot assisted laparoscopic prostatectomy. MATERIALS AND METHODS: We compared baseline demographic, clinical and health related quality of life characteristics o ... Full text Link to item Cite

Prostate-specific antigen (PSA) and PSA velocity for prostate cancer detection in men aged <50 years.

Journal article BJU Int · April 2007 Featured Publication OBJECTIVE: To identify threshold values of prostate-specific antigen (PSA) levels and PSA velocity (PSAV) to optimize the assessment of the risk of prostate cancer in young men, as prostate cancer is detected increasingly in men aged <50 years. PATIENTS AN ... Full text Link to item Cite

Medical technologies for the diagnosis of prostate cancer.

Journal article Expert Rev Med Devices · March 2007 Featured Publication Prostate cancer is an extremely prevalent problem, especially in our aging population. The prostate-specific antigen test has revolutionized prostate cancer screening. Significant advances have been made in the usage of prostate-specific antigen and its de ... Full text Link to item Cite

Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel report and recommendations for a standard in the reporting of surgical outcomes.

Journal article J Urol · February 2007 Featured Publication PURPOSE: The American Urological Association Prostate Guideline Update Panel was charged with updating the Guidelines for Clinically Localized Prostate Cancer. In assessing outcomes with treatment, it became apparent that a highly variable number of defini ... Full text Link to item Cite

Relationship between body mass index and prostate cancer screening in the United States.

Journal article J Urol · February 2007 Featured Publication PURPOSE: Obesity is associated with more advanced disease and worse outcomes in men with prostate cancer. To our knowledge the relationship between obesity and prostate cancer screening behavior in men 40 or older is unknown. Thus, we examined associations ... Full text Link to item Cite

Financial comparative analysis of minimally invasive surgery to open surgery for localized prostate cancer: a single-institution experience.

Journal article Urology · February 2007 Featured Publication OBJECTIVES: To evaluate the financial implications of how the costs of new minimally invasive surgery such as laparoscopic robotic prostatectomy (LRP) and cryosurgical ablation of the prostate (CAP) technologies compare with those of conventional surgery. ... Full text Link to item Cite

Age adjusted prostate specific antigen and prostate specific antigen velocity cut points in prostate cancer screening.

Journal article J Urol · February 2007 Featured Publication PURPOSE: We identified age adjusted prostate specific antigen and prostate specific antigen velocity cut points for prostate cancer biopsy. MATERIALS AND METHODS: A cohort of 33,643 men was retrieved from the Duke Prostate Center database. Of this group 11 ... Full text Link to item Cite

Characterization of frequently deleted 6q locus in prostate cancer.

Journal article DNA Cell Biol · November 2006 Featured Publication The long arm of chromosome 6 is frequently deleted in diverse human neoplasms. Our previous study showed a minimum deletion region between markers D6S1056 and D6S300 on chromosome 6q in primary prostate cancer (CaP). In this study, we further refined a 200 ... Full text Link to item Cite

Prostate-specific antigen-based serial screening may decrease prostate cancer-specific mortality.

Journal article Urology · August 2006 Featured Publication OBJECTIVES: To compare the preoperative characteristics, postoperative prostate-specific antigen (PSA) doubling time (DT), and prostate cancer-specific mortality (PCSM) estimates after PSA failure in men diagnosed during a screening study versus a communit ... Full text Link to item Cite

Management of the patient with a rising PSA alone.

Journal article Hematol Oncol Clin North Am · August 2006 Featured Publication PSA-only recurrence after definitive RP or RT for PCA is an increasingly com-mon scenario. The very definition of advanced prostate cancer is changing. Multimodal therapy improves cancer-specific outcomes especially in men with high-risk disease. After RP, ... Full text Link to item Cite

Prostate specific antigen testing in men older than 75 years in the United States.

Journal article J Urol · August 2006 Featured Publication PURPOSE: Although there is general agreement that men older than 75 years are unlikely to benefit from prostate specific antigen testing, patient reported testing rates in these patients exceed 30%. We examined physician reported PSA testing in elderly men ... Full text Link to item Cite

Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.

Journal article Oncol Rep · July 2006 Featured Publication In order to evaluate the molecular heterogeneity of prostate cancer, this study examined the expression of Akt-pathway related parameters within the cancerous prostate gland. PTEN, p-Akt and p27kip1 are known to be altered in prostate cancer. Tissue sample ... Link to item Cite

Update on outcomes research databases in prostate cancer 2006.

Journal article Curr Opin Urol · May 2006 Featured Publication PURPOSE OF REVIEW: The purpose of this review is to summarize single-institution prostate-cancer-outcomes databases (which are most commonly derived from large academic medical centers, Veterans Affairs medical centers, and military hospitals) to summarize ... Full text Link to item Cite

Treatment of PSA only recurrence of prostate cancer after prior local therapy.

Journal article Curr Pharm Des · 2006 Featured Publication Prostate cancer recurrence (after prior local treatment) that is detectable only by a rise in serum prostate specific antigen (PSA) level is a very common problem facing clinicians. Given that the majority of contemporary era men with PSA-only or biochemic ... Full text Link to item Cite

Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report.

Journal article Prostate Cancer Prostatic Dis · 2006 Featured Publication A 65-year-old man with a history of combined pelvic external beam radiation therapy (EBRT) and brachytherapy for prostatic adenocarcinoma 15 years prior underwent total pelvic exenteration for presumed rectal sarcoma with prostatic invasion. Pathology reve ... Full text Link to item Cite

Quantitative expression profile of PSGR in prostate cancer.

Journal article Prostate Cancer Prostatic Dis · 2006 Featured Publication PSGR is a novel member of the G-protein-coupled olfactory receptor family. Our initial report showed predominant expression of the PSGR in human prostate gland and significant alterations of PSGR expression in primary prostate cancer (CaP) specimens. The a ... Full text Link to item Cite

Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate.

Journal article Prostate Cancer Prostatic Dis · 2006 Featured Publication To determine the timing and patterns of late recurrence after radical prostatectomy (RP) alone or RP plus adjuvant radiotherapy (RT). Between 1970 and 1983, 159 patients underwent RP for newly diagnosed adenocarcinoma of the prostate and were found to have ... Full text Link to item Cite

Prostate-specific antigen versus prostate-specific antigen density as predictor of tumor volume, margin status, pathologic stage, and biochemical recurrence of prostate cancer.

Journal article Urology · December 2005 Featured Publication OBJECTIVES: To compare prostate-specific antigen (PSA) and PSA density (PSAD) calculated by transrectal ultrasound (TRUS) volume (TRUS PSAD), pathologic volume (Path PSAD), and weight (Weight PSAD) for their ability to predict pathologic characteristics an ... Full text Link to item Cite

The changing face of prostate cancer.

Journal article J Clin Oncol · November 10, 2005 Featured Publication Prostate cancer remains the most common noncutaneous human malignancy, and the second most lethal tumor among men. However, the natural history of the disease is often prolonged, and the survival benefits of local therapy for men with low-risk tumors may n ... Full text Link to item Cite

Screening for prostate cancer in military populations.

Journal article Mil Med · November 2005 Featured Publication With the widespread use of the prostate-specific antigen (PSA) test, smaller cancers are being detected among younger men and 5-year, cancer-specific, survival rates are on the rise. Although this lead-time effect may not translate into long-term improveme ... Full text Link to item Cite

Predictors of prostate cancer-specific mortality after radical prostatectomy or radiation therapy.

Journal article J Clin Oncol · October 1, 2005 Featured Publication PURPOSE: We evaluated predictors of prostate cancer-specific mortality (PCSM) after prostate-specific antigen (PSA) failure after radical prostatectomy (RP) or radiation therapy (RT). PATIENTS AND METHODS: A total of 1,159 men with clinically localized pro ... Full text Link to item Cite

Prostate-specific antigen nadir and cancer-specific mortality following hormonal therapy for prostate-specific antigen failure.

Journal article J Clin Oncol · September 20, 2005 Featured Publication PURPOSE: For men receiving androgen-suppression therapy (AST) for a rising postoperative or postradiation prostate-specific antigen (PSA), we evaluated whether a PSA nadir of more than 0.2 ng/mL was significantly associated with prostate cancer-specific mo ... Full text Link to item Cite

Radical perineal prostatectomy for the treatment of localized prostate cancer in morbidly obese patients.

Journal article J Urol · July 2005 Featured Publication PURPOSE: We assessed the feasibility of radical perineal prostatectomy (RPP) in morbidly obese patients with clinically organ confined prostate cancer. MATERIALS AND METHODS: Of 1,265 consecutive patients who underwent RPP at our institution from 1992 to 2 ... Full text Link to item Cite

Low-risk prostate cancer patient: active treatment.

Journal article Can J Urol · June 2005 Featured Publication We currently lack a prospective, randomized, multicenter trial, to reassure low-risk prostate cancer patients, especially younger ones, that watchful waiting is a legitimate treatment. To better manage these patients, we need to: first, confirm that the pa ... Link to item Cite

Treating the biochemical recurrence of prostate cancer after definitive primary therapy.

Journal article Clin Prostate Cancer · June 2005 Featured Publication As increasing numbers of men are living longer with prostate cancer, larger proportions will eventually present to our collective practices with increasing prostate-specific antigen (PSA) levels. Such PSA relapses, conservatively estimated to affect approx ... Full text Link to item Cite

Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome.

Journal article Oncogene · May 26, 2005 Featured Publication Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses, and tumorigenesis. This study, analysing laser microdissected paired benign and malignant prostate ... Full text Link to item Cite

Proteomics in prostate cancer.

Journal article Curr Opin Urol · May 2005 Featured Publication PURPOSE OF REVIEW: State-of-the-art proteomics technologies are currently being assessed for utility in the study of prostatic malignancy. This review aims to provide background information on the current proteomics techniques employed in prostate cancer r ... Full text Link to item Cite

Biochemical recurrence after definitive prostate cancer therapy. Part II: treatment strategies for biochemical recurrence of prostate cancer.

Journal article Curr Opin Urol · May 2005 Featured Publication PURPOSE OF REVIEW: Through the prostate-specific antigen era, the proportion of men less than 55 years old with newly diagnosed prostate cancer more than doubled to almost 15%. As increasing numbers of men are living longer with prostate cancer, larger pro ... Full text Link to item Cite

Biochemical recurrence after definitive prostate cancer therapy. Part I: defining and localizing biochemical recurrence of prostate cancer.

Journal article Curr Opin Urol · May 2005 Featured Publication PURPOSE OF REVIEW: The introduction of prostate-specific antigen into clinical practice heralded a dramatic shift in the epidemiology of prostate cancer. The diagnosis and treatment of lower stage disease in younger men with fewer competing co-morbidities ... Full text Link to item Cite

Rising prostate-specific antigen after primary prostate cancer therapy.

Journal article Nat Clin Pract Urol · April 2005 Featured Publication An estimated 20-40% of men experience a biochemical recurrence within 10 years of definitive prostate cancer treatment. No single prostate-specific antigen (PSA) value is invariably associated with clinical metastasis or cancer-specific survival; PSA kinet ... Full text Link to item Cite

Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility.

Journal article Clin Chem · January 2005 Featured Publication BACKGROUND: Protein expression profiling for differences indicative of early cancer has promise for improving diagnostics. This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional ev ... Full text Link to item Cite

Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line.

Journal article Anticancer Res · 2005 Featured Publication The generation of suitable in vitro models is critical for understanding the process associated with the development and progression of prostate cancer in high-risk African-American men. However, the generation of long-term human prostate epithelial cell l ... Link to item Cite