Julia Jarrard Scialla

Journal article Am J Hypertens · January 1, 2019 Featured Publication BACKGROUND: Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulato ... Full text Link to item Cite

Vitamin D Receptor Agonists for Patients Undergoing Hemodialysis.

Journal article JAMA · December 11, 2018 Featured Publication Full text Link to item Cite

Update on Chronic Kidney Disease Mineral and Bone Disorder in Cardiovascular Disease.

Journal article Semin Nephrol · November 2018 Featured Publication Chronic kidney disease mineral and bone disorder (MBD) encompasses changes in mineral ion and vitamin D metabolism that are widespread in the setting of chronic kidney disease and end-stage renal disease. MBD components associate with cardiovascular diseas ... Full text Link to item Cite

Metabolic Changes with Base-Loading in CKD.

Journal article Clin J Am Soc Nephrol · August 7, 2018 Featured Publication Full text Open Access Link to item Cite

Evidence basis for integrated management of mineral metabolism in patients with end-stage renal disease.

Journal article Curr Opin Nephrol Hypertens · July 2018 Featured Publication PURPOSE OF REVIEW: Treatment of mineral metabolism is a mainstay of dialysis care including some of its most widely used and costly pharmaceuticals. Although many mineral metabolites are associated with increased risk of mortality, cardiovascular disease, ... Full text Link to item Cite

Role of Acid-Base Homeostasis in Diabetic Kidney Disease.

Journal article Curr Diab Rep · April 2017 Featured Publication PURPOSE OF REVIEW: Acid-base homeostasis is impaired in chronic kidney disease (CKD) and may contribute to disease progression. Diabetes, a major cause of CKD worldwide, may exacerbate acidosis further due to differences in acid production and excretion. H ... Full text Link to item Cite

Intravenous iron administration strategies and anemia management in hemodialysis patients.

Journal article Nephrol Dial Transplant · January 1, 2017 Featured Publication BACKGROUND: The effect of maintenance intravenous (IV) iron administration on subsequent achievement of anemia management goals and mortality among patients recently initiating hemodialysis is unclear. METHODS: We performed an observational cohort study, i ... Full text Link to item Cite

Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes.

Journal article Kidney Int · January 2017 Featured Publication Higher diet-dependent nonvolatile acid load is associated with faster chronic kidney disease (CKD) progression, but most studies have used estimated acid load or measured only components of the gold standard, net acid excretion (NAE). Here we measured NAE ... Full text Link to item Cite

Genetic African Ancestry and Markers of Mineral Metabolism in CKD.

Journal article Clin J Am Soc Nephrol · April 7, 2016 Featured Publication BACKGROUND AND OBJECTIVES: Disorders of mineral metabolism are more common in African Americans with CKD than in European Americans with CKD. Previous studies have focused on the differences in mineral metabolism by self-reported race, making it difficult ... Full text Link to item Cite

Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression.

Journal article Clin J Am Soc Nephrol · December 7, 2015 Featured Publication BACKGROUND AND OBJECTIVES: Common apolipoprotein L1 (APOL1) variants are associated with increased risk of progressive CKD; however, not all individuals with high-risk APOL1 variants experience CKD progression. Identification of factors contributing to het ... Full text Link to item Cite

Food Access, Chronic Kidney Disease, and Hypertension in the U.S.

Journal article Am J Prev Med · December 2015 Featured Publication INTRODUCTION: Greater distance to full-service supermarkets and low income may impair access to healthy diets and contribute to chronic kidney disease (CKD) and hypertension. The study aim was to determine relationships among residence in a "food desert," ... Full text Link to item Cite

Change in estimated glomerular filtration rate and fracture risk in the Action to Control Cardiovascular Risk in Diabetes Trial.

Journal article Bone · September 2015 Featured Publication OBJECTIVE: Patients with type 2 diabetes (T2DM) are at increased risk of fracture. High prevalence of chronic kidney disease (CKD) in T2DM may contribute to bone fragility, but whether dynamic change in kidney function is associated with fracture risk is u ... Full text Link to item Cite

When there will never be a randomized controlled trial.

Journal article Kidney Int · August 2015 Featured Publication There are many unanswered questions about how to manage secondary hyperparathyroidism and associated alterations in mineral metabolism in patients with end-stage renal disease. We provide commentary on an observational study by Komaba et al. that presents ... Full text Link to item Cite

The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease.

Journal article Kidney Int · July 2015 Featured Publication Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that ... Full text Link to item Cite

Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease.

Journal article Curr Opin Nephrol Hypertens · May 2015 Featured Publication PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Animal studies have demonstrated direct and indirect effects of FGF23 that may promote heart disease. Herein, we rev ... Full text Link to item Cite

Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study.

Journal article J Am Heart Assoc · April 20, 2015 Featured Publication BACKGROUND: Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of this study was to conduct a time-updated longitudinal analysis to evaluate the association of ... Full text Open Access Link to item Cite

Effect of intravenous iron use on hospitalizations in patients undergoing hemodialysis: a comparative effectiveness analysis from the DEcIDE-ESRD study.

Journal article Nephrol Dial Transplant · April 2015 Featured Publication BACKGROUND: Intravenous iron use in hemodialysis patients has greatly increased over the last decade, despite limited studies on the safety of iron. METHODS: We studied the association of receipt of intravenous iron with hospitalizations in an incident coh ... Full text Link to item Cite

Fibroblast growth factor 23 and incident CKD in type 2 diabetes.

Journal article Clin J Am Soc Nephrol · January 7, 2015 Featured Publication BACKGROUND AND OBJECTIVES: High levels of fibroblast growth factor 23 are associated with accelerated progression of CKD. Whether high fibroblast growth factor 23 levels also predict incident CKD is uncertain. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: ... Full text Link to item Cite

Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis.

Journal article Am J Nephrol · 2015 Featured Publication BACKGROUND: Abnormalities in mineral homeostasis are ubiquitous in patients on dialysis, and influenced by race. In this study, we determine the race-specific relationship between mineral parameters and mortality in patients initiating hemodialysis. METHOD ... Full text Link to item Cite

Intravenous iron exposure and mortality in patients on hemodialysis.

Journal article Clin J Am Soc Nephrol · November 7, 2014 Featured Publication BACKGROUND AND OBJECTIVES: Clinical trials assessing effects of larger cumulative iron exposure with outcomes are lacking, and observational studies have been limited by assessment of short-term exposure only and/or failure to assess cause-specific mortali ... Full text Link to item Cite

An instrumental variable approach finds no associated harm or benefit with early dialysis initiation in the United States.

Journal article Kidney Int · October 2014 Featured Publication The estimated glomerular filtration rate (eGFR) at dialysis initiation has been rising. Observational studies suggest harm, but may be confounded by unmeasured factors. As instrumental variable methods may be less biased, we performed a retrospective cohor ... Full text Link to item Cite

Comparative effectiveness of early versus conventional timing of dialysis initiation in advanced CKD.

Journal article Am J Kidney Dis · May 2014 Featured Publication BACKGROUND: Previous observational studies examining outcomes associated with the timing of dialysis therapy initiation in the United States have often been limited by lead time and survivor bias. STUDY DESIGN: Retrospective cohort study comparing the effe ... Full text Link to item Cite

Incidental findings on cardiac computed tomography in incident hemodialysis patients: the predictors of arrhythmic and cardiovascular events in end-stage renal disease (PACE) study.

Journal article BMC Nephrol · May 1, 2014 Featured Publication BACKGROUND: This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics. METHODS: We performed a cross-sectional analysi ... Full text Link to item Cite

Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease.

Journal article Nat Rev Nephrol · May 2014 Featured Publication Disturbances in phosphate homeostasis are common in patients with chronic kidney disease. As kidney function declines, circulating concentrations of phosphate and the phosphate-regulatory hormone, fibroblast growth factor (FGF)-23, rise progressively. High ... Full text Link to item Cite

Predialysis systolic BP variability and outcomes in hemodialysis patients.

Journal article J Am Soc Nephrol · April 2014 Featured Publication BP variability (BPV) is an important predictor of outcomes in the general population, but its association with clinical outcomes in hemodialysis patients is not clear. We identified 11,291 patients starting dialysis in 2003-2008 and followed them through D ... Full text Link to item Cite

Biomarkers of vascular calcification and mortality in patients with ESRD.

Journal article Clin J Am Soc Nephrol · April 2014 Featured Publication BACKGROUND: Vascular calcification is common among patients undergoing dialysis and is associated with mortality. Factors such as osteoprotegerin (OPG), osteopontin (OPN), bone morphogenic protein-7 (BMP-7), and fetuin-A are involved in vascular calcificat ... Full text Link to item Cite

Kidney allograft survival of African American and Caucasian American recipients with lupus.

Journal article Lupus · February 2014 Featured Publication BACKGROUND: African Americans with lupus who receive kidney transplants have high prevalence of predictors of allograft failure, which can explain their poor outcomes. METHODS: Of 1223 African Americans and 1029 Caucasian Americans with lupus who received ... Full text Link to item Cite

Fibroblast growth factor-23 and cardiovascular events in CKD.

Journal article J Am Soc Nephrol · February 2014 Featured Publication An elevated level of fibroblast growth factor-23 (FGF-23) is the earliest abnormality of mineral metabolism in CKD. High FGF-23 levels promote left ventricular hypertrophy but not coronary artery calcification. We used survival analysis to determine whethe ... Full text Link to item Cite

Predialysis health, dialysis timing, and outcomes among older United States adults.

Journal article J Am Soc Nephrol · February 2014 Featured Publication Studies of dialysis initiation timing have not accounted for predialysis clinical factors that could impact postdialysis outcomes. We examined the association of predialysis health with timing of dialysis initiation in older adult patients in the United St ... Full text Link to item Cite

Trends in anemia management in US hemodialysis patients 2004-2010.

Journal article BMC Nephrol · December 1, 2013 Featured Publication BACKGROUND: There have been major changes in the management of anemia in US hemodialysis patients in recent years. We sought to determine the influence of clinical trial results, safety regulations, and changes in reimbursement policy on practice. METHODS: ... Full text Open Access Link to item Cite

Patterns in blood pressure medication use in US incident dialysis patients over the first 6 months.

Journal article BMC Nephrol · November 12, 2013 Featured Publication BACKGROUND: Several observational studies have evaluated the effect of a single exposure window with blood pressure (BP) medications on outcomes in incident dialysis patients, but whether BP medication prescription patterns remain stable or a single exposu ... Full text Open Access Link to item Cite

Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study.

Journal article Am J Kidney Dis · October 2013 Featured Publication BACKGROUND: The purpose of this study is to evaluate serum bicarbonate level as a risk factor for renal outcomes, cardiovascular events, and mortality in patients with chronic kidney disease (CKD). STUDY DESIGN: Observational cohort study. SETTING & PARTIC ... Full text Link to item Cite

Fibroblast growth factor 23 is not associated with and does not induce arterial calcification.

Journal article Kidney Int · June 2013 Featured Publication Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in patients with chronic kidney disease. As a potential mediating mechanism, FGF23 induces left ventricular hypertrophy; however, its role in arterial calcification is l ... Full text Open Access Link to item Cite

Dietary acid load: a novel nutritional target in chronic kidney disease?

Journal article Adv Chronic Kidney Dis · March 2013 Featured Publication Nonvolatile acid is produced from the metabolism of organic sulfur in dietary protein and the production of organic anions during the combustion of neutral foods. Organic anion salts that are found primarily in plant foods are directly absorbed in the gast ... Full text Link to item Cite

Choices in kidney transplantation in type 1 diabetes: are there skeletal benefits of the endocrine pancreas?

Journal article Kidney Int · March 2013 Featured Publication Previously, recipients of a simultaneous pancreas-kidney transplant versus a kidney transplant alone were thought to have higher fracture risk. Using a large US registry, Nikkel et al. observed lower rates of fracture hospitalization among patients with ty ... Full text Link to item Cite

Mineral metabolites and CKD progression in African Americans.

Journal article J Am Soc Nephrol · January 2013 Featured Publication CKD progresses more rapidly to ESRD among African Americans compared with Caucasians. Disordered mineral metabolism is more severe among African Americans with CKD, which might partially explain the accelerated progression of their kidney disease. Here, us ... Full text Link to item Cite

Inhibitors of mTOR and risks of allograft failure and mortality in kidney transplantation.

Journal article Am J Transplant · January 2013 Featured Publication Data on long-term outcomes of users of inhibitors of the mammalian target of rapamycin (mTORI) are lacking in kidney transplantation. In an analysis of 139 370 US kidney transplant recipients between 1999 through 2010, we compared clinical outcomes among u ... Full text Link to item Cite

Comparative effectiveness studies to improve clinical outcomes in end stage renal disease: the DEcIDE patient outcomes in end stage renal disease study.

Journal article BMC Nephrol · December 6, 2012 Featured Publication BACKGROUND: Evidence is lacking to inform providers' and patients' decisions about many common treatment strategies for patients with end stage renal disease (ESRD). METHODS/DESIGN: The DEcIDE Patient Outcomes in ESRD Study is funded by the United States ( ... Full text Open Access Link to item Cite

Plant protein intake is associated with fibroblast growth factor 23 and serum bicarbonate levels in patients with chronic kidney disease: the Chronic Renal Insufficiency Cohort study.

Journal article J Ren Nutr · July 2012 Featured Publication BACKGROUND: Protein from plant, as opposed to animal, sources may be preferred in chronic kidney disease (CKD) because of the lower bioavailability of phosphate and lower nonvolatile acid load. STUDY DESIGN: Observational cross-sectional study. SETTING AND ... Full text Link to item Cite

Net endogenous acid production is associated with a faster decline in GFR in African Americans.

Journal article Kidney Int · July 2012 Featured Publication Increased acid excretion may promote renal injury. To evaluate this in African Americans with hypertensive nephrosclerosis, we studied the association between the net endogenous acid production and progression of kidney disease in 632 patients in the AASK ... Full text Link to item Cite

Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease.

Journal article Diabetes Care · May 2012 Featured Publication OBJECTIVE: Disordered mineral metabolism is a common complication of chronic kidney disease (CKD) and a novel risk factor for CKD progression, cardiovascular disease, and mortality. Although diabetes is the leading cause of CKD and is associated with worse ... Full text Open Access Link to item Cite

Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease.

Journal article Clin J Am Soc Nephrol · November 2011 Featured Publication BACKGROUND AND OBJECTIVES: Osteoprotegerin (OPG), a cytokine that regulates bone resorption, has been implicated in the process of vascular calcification and stiffness. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Serum OPG was measured in 351 participan ... Full text Link to item Cite

FGF23 induces left ventricular hypertrophy.

Journal article J Clin Invest · November 2011 Featured Publication Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FGF23 ha ... Full text Link to item Cite

Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease.

Journal article Clin J Am Soc Nephrol · July 2011 Featured Publication BACKGROUND AND OBJECTIVES: Metabolic acidosis may contribute to morbidity and disease progression in patients with chronic kidney disease (CKD). The ratio of dietary protein, the major source of nonvolatile acid, to dietary potassium, which is naturally bo ... Full text Link to item Cite

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease.

Journal article JAMA · June 15, 2011 Featured Publication CONTEXT: A high level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) is associated with mortality in patients with end-stage renal disease, but little is known about its relationship with adverse outcomes in the much larger popula ... Full text Link to item Cite

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease.

Journal article Kidney Int · June 2011 Featured Publication Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong predictor of mortality in dialysis patients. FGF23 is thought to be an early biomarker of disordered phosphorus metabolism in the initial stages of chronic kidney disease ( ... Full text Link to item Cite

Soluble P-selectin levels are associated with cardiovascular mortality and sudden cardiac death in male dialysis patients.

Journal article Am J Nephrol · 2011 Featured Publication BACKGROUND/AIMS: P-selectin is released by activated platelets and endothelium contributing to inflammation and thrombosis. We evaluated the association between soluble P-selectin and atherosclerotic cardiovascular disease (ASCVD) in dialysis patients. MET ... Full text Link to item Cite

Low socioeconomic status associates with higher serum phosphate irrespective of race.

Journal article J Am Soc Nephrol · November 2010 Featured Publication Hyperphosphatemia, which associates with adverse outcomes in CKD, is more common among blacks than whites for unclear reasons. Low socioeconomic status may explain this association because poverty both disproportionately affects racial and ethnic minoritie ... Full text Link to item Cite