Scholars@Duke
Julian Nicenboim

Julian Nicenboim

Assistant Research Professor in the Department of Biomedical Engineering
Biomedical Engineering
julian.nicenboim@duke.edu
1427 FCIEMAS, 101 Science Dr Box 90281, Durham, NC 27708

Scholarly Works

Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial.

Journal article Nature communications · July 2025 Cystic fibrosis is a monogenetic disease complicated by recurrent bacterial lung infections that require chronic antibiotics. Pseudomonas aeruginosa is an increasingly antibiotic-resistant pathogen associated with cystic fibrosis morbidity and mortality. H ... Full text Cite

Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis.

Journal article Nature communications · June 2023 Primary sclerosing cholangitis (PSC) is characterized by progressive biliary inflammation and fibrosis. Although gut commensals are associated with PSC, their causative roles and therapeutic strategies remain elusive. Here we detect abundant Klebsiella pne ... Full text Cite

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.

Journal article Cell · August 2022 Human gut commensals are increasingly suggested to impact non-communicable diseases, such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a daunting unmet challenge. In four geographically distinct IBD cohorts (n = 537), we ide ... Full text Cite

Generation of specialized blood vessels via lymphatic transdifferentiation.

Journal article Nature · June 2022 The lineage and developmental trajectory of a cell are key determinants of cellular identity. In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate and specialize to cater to the unique physiological demands of each o ... Full text Link to item Cite

Development of a topical bacteriophage gel targeting Cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial

Journal article Skin Health and Disease · June 1, 2022 Background: Topical antibiotics are frequently used to treat acne vulgaris. Their prolonged use, often for longer durations than recommended, has led to antibiotic resistance in Cutibacterium acnes (C. acnes), a bacterium implicated in acne pathophysiology ... Full text Cite

BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression.

Journal article Life science alliance · April 2020 Angiogenesis and lymphangiogenesis are key processes during embryogenesis as well as under physiological and pathological conditions. Vascular endothelial growth factor C (VEGFC), the ligand for both VEGFR2 and VEGFR3, is a central lymphangiogenic regulato ... Full text Cite

Development of the lymphatic system: new questions and paradigms.

Journal article Development (Cambridge, England) · March 2016 The lymphatic system is a blind-ended network of vessels that plays important roles in mediating tissue fluid homeostasis, intestinal lipid absorption and the immune response. A profound understanding of the development of lymphatic vessels, as well as of ... Full text Cite

Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development.

Journal article Development (Cambridge, England) · December 2015 Formation and remodeling of vascular beds are complex processes orchestrated by multiple signaling pathways. Although it is well accepted that vessels of a particular organ display specific features that enable them to fulfill distinct functions, the embry ... Full text Cite

Lymphatic vessels arise from specialized angioblasts within a venous niche.

Journal article Nature · June 2015 How cells acquire their fate is a fundamental question in developmental and regenerative biology. Multipotent progenitors undergo cell-fate restriction in response to cues from the microenvironment, the nature of which is poorly understood. In the case of ... Full text Cite

Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish.

Journal article The Journal of neuroscience : the official journal of the Society for Neuroscience · September 2012 Sleep is an essential biological need of all animals studied to date. The sleep disorder narcolepsy is characterized by excessive daytime sleepiness, fragmentation of nighttime sleep, and cataplexy. Narcolepsy is caused by selective degeneration of hypotha ... Full text Cite