Overview
Dr. Zhang joined the Duke Faculty in fall 2013 from the University of Southern California where he had been a professor of environmental and global health and the director of Environmental and Biomarkers Analysis Laboratory since 2010. His prior positions include professor, department chair, and associate dean at the Rutgers School of Public Health. Dr. Zhang has more than 290 peer-reviewed publications. His work has been featured in major international media such as the Time, the New York Times, BBC, ABC, CBS, Yahoo News, etc. His early work on characterizing sources of non-methane greenhouse gases made him one of the officially recognized contributor to the 2007 Nobel Peace Prize awarded to IPCC. He is the 2012 recipient of the Jeremy Wesolowski Award, the highest award of the International Society of Exposure Science. He also received a Distinguished Alumni Award from the Rutgers Graduate School.
Dr. Zhang’s research interests include developing novel biomarkers of human exposure and health effects, assessing health and climate co-benefits of air pollution interventions, and examining biological mechanisms by which environmental exposures exert adverse health effects. Dr. Zhang has led a number of international collaborations to study air pollution health effects and underlying pathophysiologic mechanisms. These studies integrate epidemiological and toxicological approaches into natural experiment designs. He has conducted several indoor air purification intervention studies to evaluate the effectiveness of personal exposure reduction in improving health outcomes in China. Currently, he is conducting intervention trials of residential air purification in older adults with a heart disease history and adults at risk for Type 2 diabetes living in Los Angels where air pollution levels are high. He is co-leading a project to study whether and how particulate matter pollution affects respiratory viral infections in two cities of Mongolia.
Current Duke Appointments & Affiliations
Recent Scholarly Works
Controlled full-body human exposure to ozone increases malondialdehyde on skin.
Journal article Environ Res · November 1, 2026 Malondialdehyde (MDA), a product of lipid peroxidation, is a biomarker of oxidative stress. We investigated the relationship between ozone exposure and MDA in skin wipes in a series of three controlled full-body chamber studies. Twenty-nine volunteers were ... Full text Link to item CiteAir Pollution Triggers Metabolomic Signature of Mitochondrial Dysfunction in Mice and Humans: Implications for Cardiovascular Disease Development.
Journal article Arterioscler Thromb Vasc Biol · September 24, 2026 BACKGROUND: Previous animal studies found that subchronic exposure to diesel exhaust induces hyperlipidemia, accompanied by upregulation of 12-LOX (lipoxygenase) and 15-LOX pathways and hepatic mitochondrial dysfunction. However, the human relevance of the ... Full text Link to item CiteWhole-blood metal(loid) profiles including macroelements in relation to short-term glycemic status: A metallome-based analysis.
Journal article Environ Pollut · September 18, 2026 Metals and metalloids (collectively referred to as metal(loid)s) have been implicated in glucose dysregulation, yet interpreting such associations remains challenging because multiple metal(loid)s coexist within complex biological elemental profiles. Whole ... Full text Link to item CiteRecent Grants
Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2019 - 2029Investigating the Role of Polyunsaturated Fatty Acid Metabolism in Airway Epithelial Cell Ozone Responses
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2026 - 2028Identifying Exposure Biomarkers of Wildland-Urban Interface Fires (WUI) Among Firefighters
ResearchCo Investigator · Awarded by National Institutes of Health · 2026 - 2028View All Grants