ConferenceProceedings of SPIE the International Society for Optical Engineering · March 5, 2026
The complexity of biomedical research, particularly studies of brain activity, the tumor microenvironment, and aging, demands imaging technologies capable of concurrently revealing multiple aspects of tissue pathology and physiology. Traditional single-mod ...
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ConferenceThe Journal of the Acoustical Society of America · March 1, 2023
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Passive cavitation mapping (PCM), which generates images using bubble acoustic emission signals, has been increasingly used for monitoring and guiding focused ultrasound surgery. This study investigates a transient angular spectrum (AS) approach fo ...
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ConferenceThe Journal of the Acoustical Society of America · March 1, 2023
Compared with visible light, near-infrared (NIR) light (700–1300 nm) is capable of deep-tissue penetration because of low tissue attenuation, and thus holds great promise for deep-tissue optical manipulation and imaging. In this work, we take advan ...
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ConferenceThe Journal of the Acoustical Society of America · March 1, 2023
Shock wave lithotripsy (SWL) and laser lithotripsy (LL) have been widely used for clinical treatment of kidney stones. Cavitation plays an important role in stone fragmentation in both SWL and LL, yet it may also contribute to renal tissue injury. ...
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ConferenceIEEE International Ultrasonics Symposium Ius · January 1, 2023
Photoacoustic (PA) imaging is an emerging hybrid medical imaging modality involving the optical excitation of chromophores - light-sensitive molecules like hemoglobin and lipids, to infer underlying vascular structure. Supplying them energy in the form of ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022
Skin and subcutaneous tumors are widespread in dogs and cats. Current tumor diagnostics (e.g., biopsy, fine-needle cytology) is invasive and labor-consuming. In this work, we studied ex vivo the most common canine and feline tumor OCT images using sliding ...
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ConferenceIEEE International Ultrasonics Symposium Ius · September 7, 2020
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Ultrasound-enhanced thrombolysis, or sonothrombolysis, has been actively investigated due to its relatively high efficiency and better safeness compared with traditional thrombolysis methods such as mechanical thrombectomy and pharmaceutical treatment. Mos ...
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Conference2020 IEEE Photonics Conference IPC 2020 Proceedings · September 1, 2020
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We present our recent progress on a super-fast photoacoustic microscopy with an ultra-wide field of view. By using a novel polygon mirror scanner that can be immersed in water, we have achieved a B-scan frame rate of 2000 Hz with a scanning range of at lea ...
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Conference2020 IEEE Photonics Conference IPC 2020 Proceedings · September 1, 2020
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We developed a new low-cost fiber diffuser based on a graded-scattering method and uniform light emission was achieved by performing numerical simulations on several key design parameters. Proof-of-concept studies on phantoms and swine model have demonstra ...
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ConferenceCancer Research · August 15, 2020
AbstractIn low-resource settings, surgery or radiation are inaccessible to 90% of cancer patients due to inadequate infrastructure and lack of trained personnel. Resource appropriate technologies must be dev ...
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ConferenceConference Proceedings International Research Council on the Biomechanics of Injury Ircobi · January 1, 2020
The occurrence of cavitation in the brain from blunt impact is difficult to investigate and remains controversial. The objective of this study was to investigate cavitation formation from blunt impact, without compromising the cranial cavity, using novel a ...
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ConferenceProceedings of the IEEE Conference on Nanotechnology · July 1, 2019
Intravascular ultrasound thrombolysis has shown its advantages in the improved treatment rate compared with traditional administration of thrombolytic agents, and a safer treatment procedure compared with mechanical drilling methods. However, the method st ...
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ConferenceDiabetes · June 1, 2019
Endothelial dysfunction is an initiating key step for diabetic macrovascular complications, and it is closely related to the hemodynamic microenvironment in vivo. However, diabetic patients usually coexist with other cardiovascular risk factors, an ...
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ConferenceNondestructive Characterization and Monitoring of Advanced Materials, Aerospace, Civil Infrastructure, and Transportation XIII · April 1, 2019Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
Photoacoustic (PA) computed tomography (PACT) is a non-invasive imaging technique offering optical contrast, high resolution, and deep penetration in biological tissues. PACT, highly sensitive to optical absorption by molecules, is inherently suited for mo ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019
Photoacoustic imaging (PAI) is a promising imaging technique in preclinical study, which combines both merits of optical and ultrasound imaging. However, PA image quality is seriously suffered from various noises such as random white noise, intrinsic noise ...
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ConferenceOptics Infobase Conference Papers · January 1, 2018
We present our recent progress on a super-fast photoacoustic microscopy with an ultrawide field of view. By using a novel polygon mirror scanner that can be immersed in water, we have achieved a B-scan frame rate of 1000 Hz with a scanning range of at leas ...
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Conference2017 Conference on Lasers and Electro Optics CLEO 2017 Proceedings · October 25, 2017
We have developed fast functional photoacoustic microscopy for 3D high- resolution high-speed imaging of the mouse brain. In particular, a novel single-wavelength pulse- width-based method can image blood oxygenation with capillary-level resolution at 100 ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017
Metastasis is responsible for as many as 90% of cancer-related deaths, and the deadliest skin cancer, melanoma, has a high propensity for metastasis. Since hematogenous spread of circulating tumor cells (CTCs) is cancer's main route of metastasis, detectin ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017
Small animal whole-body imaging, providing physiological, pathological, and phenotypical insights into biological processes, is indispensable in preclinical research. With high spatiotemporal resolution and functional contrast, small animal imaging can vis ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 18, 2016
Optical imaging of genetically encoded probes has revolutionized biomedical studies by providing valuable information about targeted biological processes. Here, we report a novel imaging technique, termed reversibly switchable photoacoustic tomography (RS- ...
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ConferenceOptics and the Brain Brain 2015 · April 6, 2015
We have developed fast functional photoacoustic microscopy (ffPAM). which can be utilized for three-dimensional morphological, functional, flow dynamic and metabolic mouse brain imaging through an intact skull with endogenous contrast only. ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 11, 2015
Melanoma, one of the most common types of skin cancer, has a high mortality rate, mainly due to a high propensity for tumor metastasis. The presence of circulating tumor cells (CTCs) is a potential predictor for metastasis. Label-free imaging of single cir ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 11, 2015
Combining the absorption-based photoacoustic effect and intensity-dependent photobleaching effect, we demonstrate a simple method for super-resolution photoacoustic imaging of both fluorescent and non-fluorescent samples. Our method is based on a double-ex ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 11, 2015
Intravital microscopy techniques have become increasingly important in biomedical research because they can provide unique microscopic views of various biological or disease developmental processes in situ. Here we present an optical-resolution photoacoust ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 11, 2015
The addition of photoacoustic endoscopy to conventional endoscopic ultrasound offers imaging capabilities that may improve diagnosis and clinical care of gastrointestinal tract diseases. In this study, using a 3.8-mm diameter dual-mode photoacoustic and ul ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 3, 2014
We propose time and frequency domain methods for homogenous flow measurement based on the photoacoustic Doppler effect. Excited by spatially modulated laser pulses, the flowing medium induces a Doppler frequency shift in the received photoacoustic signals. ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 3, 2014
Both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (ORPAM) deteriorate sharply with depth due to strong light scattering in tissue. To reduce tissue scattering, we propose to use glycerol as an optical ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014
Currently, laser fluence calibration is typically required for quantitative measurement of particle concentration in photoacoustic microscopy. In this paper, we present another quantitative approach to measure absolute absorber concentrations by photoacous ...
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ConferenceOptics express · January 2014
Many diseases involve either the formation of new blood vessels (e.g., tumor angiogenesis) or the damage of existing ones (e.g., diabetic retinopathy) at the microcirculation level. Optical-resolution photoacoustic microscopy (OR-PAM), capable of imaging m ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 28, 2013
It is a challenge to non-invasively visualize in vivo the neovascularization in a three-dimensional (3D) scaffold with high spatial resolution and deep penetration depth. Here we used photoacoustic microscopy (PAM) to chronically monitor neovascularization ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 28, 2013
To control the overall action of the body, brain consumes a large amount of energy in proportion to its volume. In humans and many other species, the brain gets most of its energy from oxygen-dependent metabolism of glucose. An abnormal metabolic rate of g ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 28, 2013
By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging spe ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · March 13, 2013
For both ultrasound and photoacoustic microscopic imaging, a fast scanning ability is required, whereas the liquid environment for acoustic propagation limits the usage of traditional MEMS scanning mirrors. In this paper, a new waterimmersible scanning mir ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 4, 2013
The axial resolution of photoacoustic microscopy (PAM) is much lower than its lateral resolution, which resolves down to the submicron level. Here we achieved so far the highest axial resolution of 7.6 μm by using a commercial 125 MHz ultrasonic transducer ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 4, 2013
Like ultrasound endoscopy, photoacoustic endoscopy (PAE) could become a valuable addition to clinical practice due to its deep imaging capability. Results from our recent in vivo transesophageal endoscopic imaging study on rabbits demonstrate the technique ...
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ConferenceOptics InfoBase Conference Papers · January 1, 2013
Photoacoustic microscopy (PAM) is a hybrid imaging technique that acoustically detects optical contrast via the photoacoustic effect. With its excellent scalability, PAM can simultaneously image anatomical, functional, molecular, flow dynamic, and metaboli ...
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ConferenceOptics Infobase Conference Papers · January 1, 2013
Photoacoustic microscopy (PAM) is a hybrid imaging technique that acoustically detects optical contrast via the photoacoustic effect. With its excellent scalability, PAM can simultaneously image anatomical, functional, molecular, flow dynamic, and metaboli ...
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ConferenceCancer Research · April 15, 2012
AbstractSigma-2 receptor binding sites, recently identified as progesterone receptor membrane component 1 (PGRMC1) (Nature Communications, 2011; 2:380), are highly expressed in tumor cells. We have previousl ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · April 9, 2012
Photoacoustic endoscopy (PAE) provides unique functional information with high spatial resolution at super depths. The provision of functional information is predicated on its strong spectroscopic imaging ability, and its deep imaging capability is derived ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 15, 2012
We developed multi-contrast photoacoustic microscopy (PAM) for in vivo anatomical, functional, metabolic, and molecular imaging. This technical innovation enables comprehensive understanding of the tumor microenvironment. With multi-contrast PAM, we longit ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 23, 2012
Massive small bowel resection (SBR) results in villus angiogenesis and intestinal adaptation. The exact mechanism that causes intestinal villus angiogenesis remains unknown. We hypothesize that hemodynamic changes within the remnant bowel after SBR will tr ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 23, 2012
As two hallmarks of cancer, angiogenesis and hypermetabolism are closely related to increased blood flow. Volumetric blood flow measurement is important to understanding the tumor microenvironment and developing new means to treat cancer. Current photoacou ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 23, 2012
pH is a tightly regulated indicator of metabolic activity. In mammalian systems, imbalance of pH regulation may result from or result in serious illness. Even though the regulation system of pH is very robust, tissue pH can be altered in many diseases such ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 23, 2012
We have developed a 2.5-mm outer diameter photoacoustic endoscopic mini-probe to use in the instrument channel (typically 2.8 or 3.7 mm in diameter) of standard video endoscopes. To achieve adequate signal sensitivity, we fabricated a focused ultrasonic tr ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 9, 2012
Genetically encoded probes powerfully and non-invasively target specific tissues, cells, and subcellular locations. iRFP, a novel near-infrared fluorescent protein with low quantum yield whose absorption and fluorescence maxima are located at wavelengths l ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · March 31, 2011
Photoacoustic microscopy (PAM) utilizes short laser pulses to deposit energy into light absorbers and sensitively detects the ultrasonic waves the absorbers generate in response. PAM directly renders a three-dimensional spatial distribution of sub-surface ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 17, 2011
Many diseases, normal decay and physiological functions are closely related to alterations in the metabolic rate of oxygen (MRO2). In this study, we demonstrate that all the parameters for MRO2 quantification can be simultaneously obt ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 10, 2011
It is difficult to distinguish between tumor cells and surrounding cells without staining as is done in histology. We developed tyrosinase-catalyzed melanin as a reporter gene for photoacoustic tomography. Tyrosinase is the primary enzyme responsible for t ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 10, 2011
Functional photoacoustic microscopy is a valuable tool in quantifying hemoglobin oxygenation within single vessels. In several functional studies with this tool, quantitative sO2 measurements were taken both in vitro and in vivo. Although in vit ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 10, 2011
Photoacoustic tomography detecting ultrasound signals generated from photon absorption provides optical absorption contrast in vivo for structural, functional and molecular imaging. Although photoacoustic tomography technology has grown fast in recent year ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 23, 2010
Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBC) as an endogenous co ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 12, 2010
Advances in the brain functional imaging greatly facilitated the understanding of neurovascular coupling. For monitoring of the microvascular response to the brain electrical stimulation in vivo we used optical-resolution photoacoustic microscopy (OR-PAM) ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 11, 2010
In photoacoustic (PA) imaging of microvascular networks, the transverse component of the blood flow that is perpendicular to the acoustic probing beam is usually dominant. We propose a new method to measure the transverse flow, based on the Doppler bandwid ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · February 11, 2010
A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF- ...
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ConferenceBiomedical Engineering and Informatics New Development and the Future Proceedings of the 1st International Conference on Biomedical Engineering and Informatics Bmei 2008 · January 1, 2008
The CCD-based non-contact fluorescent optical imaging has got a promising progress in recent years. This imaging modality needs the 3D surface of the small animal, which is used for the forward model and inverse reconstruction. We propose a new 3D surface ...
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