Scholars@Duke
Junjie Yao

Junjie Yao

Jeffrey N. Vinik Associate Professor of Biomedical Engineering
Biomedical Engineering
Room 1427, Fitzpatrick CIEMAS, 101 Science Drive, PO Box 90281, Durham, NC 27708
Hudson Hall Annex 261, Durham, NC 27708
Office hours Monday to Friday: 9:30 am to 6:00 pm (walk-in welcome)  

Scholarly Works - Journal articles

Sonicated inks and focused-ultrasound writing enable deep-penetration acoustic volumetric printing.

Journal article Nature protocols · July 2026 Volumetric printing is an emerging additive manufacturing technique that builds 3D constructs with enhanced printing speed and surface quality by forgoing the stepwise ink renewal. Existing volumetric printing techniques almost exclusively rely on light en ... Full text Cite

Noninvasive whole-brain imaging of glymphatic dynamics.

Journal article Sci Adv · June 19, 2026 Cerebrospinal fluid circulation through the glymphatic system plays a crucial role in removing metabolic waste from the central nervous system. However, the mechanism underlying the brain-wide glymphatic dynamics is not yet fully understood, in part due to ... Full text Link to item Cite

Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.

Journal article Placenta · March 30, 2026 The placenta is a transient yet vital organ that regulates maternal-fetal exchange and profoundly influences pregnancy outcomes. Placental hemodynamic dysfunction is central to many major obstetric complications, including preeclampsia and fetal growth res ... Full text Link to item Cite

Revealing hidden tissue architecture with mid-infrared dichroism photoacoustic microscopy.

Journal article Light, science & applications · February 2026 By combining mid-infrared excitation with polarization-resolved photoacoustics, Park et al. introduce a novel label-free approach to visualize both molecular composition and fiber alignment in engineered tissues. This dual-contrast framework, termed MIR-DS ... Full text Cite

Dual-channel high-speed functional photoacoustic microscopy with ultra-wide field of view.

Journal article Light, science & applications · January 2026 Photoacoustic microscopy (PAM) systems often face challenges in simultaneously achieving high speed, high resolution, high sensitivity, and a large field of view (FOV). To address this challenge, we have developed dual-channel PAM (DC-PAM) that can expand ... Full text Cite

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies.

Journal article J Vis Exp · December 12, 2025 Transcranial ultrasonic stimulation (TUS) is emerging as a non-invasive neuromodulatory technique capable of delivering millimeter-precision stimulation at whole-brain depths. Research efforts have increasingly focused on its translational potential. Promi ... Full text Link to item Cite

Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice.

Journal article Nat Commun · December 3, 2025 The critical events that trigger sepsis progression into life-threatening septic shock remain unclear. In agreement with reports that link a drop in platelet count to a complicated clinical course in sepsis patients, here we report that, during sepsis, mou ... Full text Link to item Cite

Label-free photoacoustic imaging of glassfrog development.

Journal article Photoacoustics · December 2025 A primary focus of contemporary biology is to understand how internal molecules influence natural development. Many amphibians serve as highly effective model organisms for this research due to their rapid growth rates and transparent tissues, which facili ... Full text Cite

Transform waste into profit: Extract licorice residue fiber to load Zr-MOF as a promising adsorbent.

Journal article Bioresource technology · December 2025 The research on the reuse of resources is crucial for achieving high-value utilization of traditional Chinese medicine (TCM). In this study, licorice residues were selected to extract fibers by alkaline hydrogen peroxide oxidation because of their high cel ... Full text Cite

Solving multiscale dynamical systems by deep learning

Journal article Computer Physics Communications · November 2025 Full text Cite

A Comparison of Image Reconstruction Methods for Ring-Array Photoacoustic Computed Tomography.

Journal article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · October 2025 This work compares the effectiveness of four image reconstruction techniques for a ring-array photoacoustic computed tomography (PACT) system: the delay-and-sum (DAS), the interpolated model matrix inversion (IMMI), the frequency-domain model-based (FDMB), ... Full text Cite

Indocyanine green (ICG) enhances penetration of 1300 nm optical coherence tomography imaging for in vivo murine skin.

Journal article Optics letters · September 2025 Optical scattering in biological tissues presents a major challenge for achieving deep penetration in optical coherence tomography (OCT). Recent approaches leveraging the Kramers-Kronig (KK) relations suggest that strongly absorbing dyes can reduce scatter ... Full text Cite

Light and metabolism: label-free optical imaging of metabolic activities in biological systems [Invited].

Journal article Biomedical optics express · September 2025 Metabolic imaging is critical for understanding cellular functions beyond morphology, offering significant insights into various biological processes and disease states. Label-free optical imaging techniques stand out by providing high-resolution, molecula ... Full text Cite

The anti-inflammatory mechanism of a new skeleton alkaloid isolated from Portulaca oleracea L.

Journal article Fitoterapia · September 2025 A new skeleton alkaloid was isolated from Portulaca oleracea L., which was identified as ethyl (2Z,4E,6E)-3-amino-7-(4-amino-6-ethyl-3-glycyl-5-methylpyridin-2-yl)-2-methylocta-2,4,6-trienoate, trivial named, olerapyridin and the structure was clarified th ... Full text Cite

Advancing precision photothermal therapy by integrating armored gold nanostars with real-time photoacoustic thermometry and imaging.

Journal article Sci Adv · August 15, 2025 Nanoparticle-mediated photothermal therapy (PTT) is a promising strategy for cancer treatment; however, nanoparticle instability and lack of precise imaging tools for real-time temperature monitoring during therapy and nanoparticle tracking have hindered i ... Full text Link to item Cite

Research of Hierarchical Vertiport Location Based on Lagrange Relaxation

Journal article Aerospace · July 28, 2025 With the rise of the low-altitude urban traffic system, urban air mobility (UAM) has developed rapidly. As a critical component of the UAM system, the strategic layout of vertiports helps divert ground traffic pressure. To satisfy various demand pa ... Full text Cite

Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout.

Journal article Nat Commun · July 14, 2025 Performance of near-infrared probes and optogenetic tools derived from bacterial phytochromes is limited by availability of their biliverdin chromophore. To address this, we use a biliverdin reductase-A knock-out mouse model (Blvra-/-), which elevates endo ... Full text Link to item Cite

A duet: Seeing and hearing the brain in action.

Journal article Science advances · July 2025 A hybrid photoacoustic-fluorescence microscope films oxygen-carrying blood and spike-firing neurons across the mouse cortex in real time, revealing the hidden duet of neurovascular coupling. ... Full text Cite

Numerical and experimental investigations of a twisted copper heat exchanger with triply periodic minimal surfaces

Journal article International Communications in Heat and Mass Transfer · June 2025 Full text Cite

Letter to the editor concerning "magnetic resonance imaging ultrasonography fusion-guided transforaminal epidural steroid injection: a retrospective cohort" by Ahmet Sumen et al. (Eur spine J [2025]: doi.org/10.1007/s00586-025-08705-3).

Journal article European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · May 2025 Full text Cite

Acoustic loudness factor as an experimental parameter for benchmarking small molecule photoacoustic probes.

Journal article Nature communications · April 2025 Photoacoustic imaging (PAI) is an emerging biomedical imaging modality with promise as a point-of-care diagnostic. This imaging modality relies on optical excitation of an absorber followed by production of ultrasound through the photoacoustic effect, resu ... Full text Cite

Non-Invasive Deep-Brain Imaging With 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).

Journal article IEEE Trans Med Imaging · February 2025 Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While PACT can quantify ... Full text Link to item Cite

Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy.

Journal article Small (Weinheim an der Bergstrasse, Germany) · February 2025 Cuproptosis, a newly defined cell death process, represents a novel modality with significant therapeutic potential in cancer treatment. Nevertheless, the modest concentration and transient half-life of copper ions in the bloodstream constrain their effici ... Full text Cite

Three-dimensional diffractive acoustic tomography.

Journal article Nat Commun · January 29, 2025 Acoustically probing biological tissues with light or sound, photoacoustic and ultrasound imaging can provide anatomical, functional, and/or molecular information at depths far beyond the optical diffusion limit. However, most photoacoustic and ultrasound ... Full text Link to item Cite

Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy <i>in vivo</i> enabled by absorbing dye molecules.

Journal article Optica · January 2025 The scattering and absorption of light within biological tissue severely limits the penetration depth of optical imaging techniques. Recently, it has been found that water-soluble, strongly absorbing dye molecules, such as tartrazine, can achieve in viv ... Full text Cite

Eavesdrop at Clinical Depths: Deep Photoacoustic Imaging with Internal Light Illumination

Journal article Advanced Devices and Instrumentation · January 1, 2025 Photoacoustic imaging (PAI) is a hybrid image modality that combines optical absorption contrast and acoustic detection of light-induced ultrasound waves. PAI can produce high-resolution and molecular-sensitive images of deep tissues, which are useful for ... Full text Cite

Three-Dimensional Super-Resolution Passive Cavitation Mapping in Laser Lithotripsy.

Journal article IEEE Trans Ultrason Ferroelectr Freq Control · December 2024 Kidney stone disease is a major public health issue. By breaking stones with repeated laser irradiation, laser lithotripsy (LL) has become the main treatment for kidney stone disease. Laser-induced cavitation is closely associated with stone damage in LL. ... Full text Open Access Link to item Cite

Sound Out the Deep Clarity: Super-Resolution Photoacoustic Imaging at Depths.

Journal article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · December 2024 Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a hybrid imaging modality that combines the rich contrast of optical imaging with the deep penetration of ultrasound (US) imaging. Over the past decade, PAI has been increasingly utilized ... Full text Cite

Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo.

Journal article Light, science & applications · October 2024 Advancements in precision medicine necessitate understanding drug clearance pathways, especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose radiation hazards, whereas optical imaging poses challenges in maintaining bot ... Full text Cite

On-demand expansion fluorescence and photoacoustic microscopy (ExFLPAM).

Journal article Photoacoustics · August 2024 Expansion microscopy (ExM) is a promising technology that enables nanoscale imaging on conventional optical microscopes by physically magnifying the specimens. Here, we report the development of a strategy that enables i) on-demand labeling of subcellular ... Full text Cite

Virtual-point-based deconvolution for optical-resolution photoacoustic microscopy.

Journal article Journal of biophotonics · August 2024 Optical-resolution photoacoustic microscopy (OR-PAM) has been increasingly utilized for in vivo imaging of biological tissues, offering structural, functional, and molecular information. In OR-PAM, it is often necessary to make a trade-off between imaging ... Full text Cite

Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications.

Journal article Advanced drug delivery reviews · May 2024 Featured Publication Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a closer mimicry of human physiology compared to traditional two-dimensional cell culture systems or non-primate animal models. While many organoid cultures use cell ... Full text Cite

Exploring the association between multiple factors and urolithiasis: A retrospective study and Mendelian randomization analysis.

Journal article Medicine · May 2024 To investigate the relationship between several factors and urinary stone as well as different stone compositions. To guide the diagnosis, treatment, and prevention of urinary stone recurrence. We used bidirectional Mendelian randomization to analyze the c ... Full text Cite

Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment.

Journal article Cell Stem Cell · April 4, 2024 Brain injury is highly associated with preterm birth. Complications of prematurity, including spontaneous or necrotizing enterocolitis (NEC)-associated intestinal perforations, are linked to lifelong neurologic impairment, yet the mechanisms are poorly und ... Full text Link to item Cite

Longitudinal intravital imaging of mouse placenta.

Journal article Sci Adv · March 22, 2024 Featured Publication Studying placental functions is crucial for understanding pregnancy complications. However, imaging placenta is challenging due to its depth, volume, and motion distortions. In this study, we have developed an implantable placenta window in mice that enabl ... Full text Open Access Link to item Cite

Multi-molecular hyperspectral PRM-SRS microscopy.

Journal article Nat Commun · February 21, 2024 Featured Publication Lipids play crucial roles in many biological processes. Mapping spatial distributions and examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical to better understanding their roles in aging and diseases. Commonly use ... Full text Link to item Cite

On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography.

Journal article IEEE transactions on medical imaging · February 2024 Featured Publication In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets. Low-frequency photo ... Full text Cite

On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography.

Journal article IEEE Trans Med Imaging · February 2024 Featured Publication In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets. Low-frequency photo ... Full text Link to item Cite

Sounding out the dynamics: a concise review of high-speed photoacoustic microscopy.

Journal article Journal of biomedical optics · January 2024 Featured Publication SignificancePhotoacoustic microscopy (PAM) offers advantages in high-resolution and high-contrast imaging of biomedical chromophores. The speed of imaging is critical for leveraging these benefits in both preclinical and clinical settings. Ongoing ... Full text Cite

High speed innovations in photoacoustic microscopy.

Journal article Npj imaging · January 2024 Photoacoustic microscopy (PAM) is a key implementation of photoacoustic imaging (PAI). PAM merges rich optical contrast with deep acoustic detection, allowing for broad biomedical research and diverse clinical applications. Recent advancements in PAM techn ... Full text Cite

Deep tissue photoacoustic imaging with light and sound.

Journal article Npj imaging · January 2024 Photoacoustic computed tomography (PACT) can harvest diffusive photons to image the optical absorption contrast of molecules in a scattering medium, with ultrasonically-defined spatial resolution. PACT has been extensively used in preclinical research for ... Full text Cite

Shock waves generated by toroidal bubble collapse are imperative for kidney stone dusting during Holmium:YAG laser lithotripsy.

Journal article Ultrasonics sonochemistry · December 2023 Featured Publication Holmium:yttrium-aluminum-garnet (Ho:YAG) laser lithotripsy (LL) has been the treatment of choice for kidney stone disease for more than two decades, yet the mechanisms of action are not completely clear. Besides photothermal ablation, recent evidence sugge ... Full text Cite

Self-enhancing sono-inks enable deep-penetration acoustic volumetric printing.

Journal article Science (New York, N.Y.) · December 2023 Featured Publication Volumetric printing, an emerging additive manufacturing technique, builds objects with enhanced printing speed and surface quality by forgoing the stepwise ink-renewal step. Existing volumetric printing techniques almost exclusively rely on light energy to ... Full text Cite

Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors.

Journal article Photoacoustics · December 2023 Featured Publication Combining the diffusive laser excitation and the photoacoustic signals detection, photoacoustic computed tomography (PACT) is uniquely suited for deep tissue imaging. A diffraction-limited ultrasound point detector is highly desirable for maximizing the sp ... Full text Cite

A frequency-domain model-based reconstruction method for transcranial photoacoustic imaging: A 2D numerical investigation.

Journal article Photoacoustics · October 2023 Featured Publication Phase aberration caused by the skull is a major barrier to achieving high quality photoacoustic images of human and non-human primates' brains. To address this issue, time-reversal methods have been used but they are computationally demanding and slow due ... Full text Cite

From Ultraviolet to Near-Infrared: Label-Free Reflection-Mode Hyperspectral Photoacoustic Microscopy for Single-Cell Biochemical Mapping

Journal article GEN Biotechnology · October 1, 2023 Featured Publication Hyperspectral imaging has emerged as a valuable technique for analyzing biological tissue compositions by probing intrinsic or exogenous biomolecules. However, conventional hyperspectral imaging methods predominantly rely on fl ... Full text Cite

Multiscale photoacoustic tomography using reversibly switchable thermochromics.

Journal article Journal of biomedical optics · August 2023 Featured Publication SignificanceBased on acoustic detection of optical absorption, photoacoustic tomography (PAT) allows functional and molecular imaging beyond the optical diffusion limit with high spatial resolution. However, multispectral functional and molecular ... Full text Cite

Miniaturized Stacked Transducer for Intravascular Sonothrombolysis With Internal-Illumination Photoacoustic Imaging Guidance and Clot Characterization.

Journal article IEEE transactions on bio-medical engineering · August 2023 Featured Publication Thromboembolism in blood vessels can lead to stroke or heart attack and even sudden death unless brought under control. Sonothrombolysis enhanced by ultrasound contrast agents has shown promising outcome on effective treatment of thromboembolism. Intravasc ... Full text Cite

Epinephrine-induced Effects on Cerebral Microcirculation and Oxygenation Dynamics Using Multimodal Monitoring and Functional Photoacoustic Microscopy.

Journal article Anesthesiology · August 1, 2023 Featured Publication BACKGROUND: The administration of epinephrine after severe refractory hypotension, shock, or cardiac arrest restores systemic blood flow and major vessel perfusion but may worsen cerebral microvascular perfusion and oxygen delivery through vasoconstriction ... Full text Link to item Cite

Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.

Journal article Applied physics letters · August 2023 Featured Publication Endovascular sonothrombolysis has gained significant attention due to its benefits, including direct targeting of the thrombus with sonication and reduced side effects. However, the small aperture of endovascular transducers restricts the improvement of th ... Full text Cite

Editorial: Breaking the speed limits in photoacoustic microscopy.

Journal article Photoacoustics · August 2023 Featured Publication Full text Cite

Non-invasive Deep-Brain Imaging with 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).

Journal article ArXiv · July 27, 2023 Featured Publication Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While PACT can quantify ... Link to item Cite

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke.

Journal article J Vis Exp · June 2, 2023 Featured Publication Presented here is an experimental ischemic stroke study using our newly developed noninvasive imaging system that integrates three acoustic-based imaging technologies: photoacoustic, ultrasound, and angiographic tomography (PAUSAT). Combining these three m ... Full text Link to item Cite

The sound of blood: photoacoustic imaging in blood analysis.

Journal article Med Nov Technol Devices · June 2023 Featured Publication Blood analysis is a ubiquitous and critical aspect of modern medicine. Analyzing blood samples requires invasive techniques, various testing systems, and samples are limited to relatively small volumes. Photoacoustic imaging (PAI) is a novel imaging modali ... Full text Link to item Cite

Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation.

Journal article J Vis Exp · April 14, 2023 Featured Publication Most cardiac arrest (CA) survivors experience varying degrees of neurologic deficits. To understand the mechanisms that underpin CA-induced brain injury and, subsequently, develop effective treatments, experimental CA research is essential. To this end, a ... Full text Link to item Cite

Photoacoustic imaging with limited sampling: a review of machine learning approaches.

Journal article Biomedical optics express · April 2023 Featured Publication Photoacoustic imaging combines high optical absorption contrast and deep acoustic penetration, and can reveal structural, molecular, and functional information about biological tissue non-invasively. Due to practical restrictions, photoacoustic imaging sys ... Full text Cite

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.

Journal article Commun Biol · March 9, 2023 Featured Publication The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR) pathways in the brain, we unexpectedly discovered that transgenic mice (XBP1s-TG) expressing spliced X-box ... Full text Link to item Cite

Dissimilar cavitation dynamics and damage patterns produced by parallel fiber alignment to the stone surface in holmium:yttrium aluminum garnet laser lithotripsy.

Journal article Physics of fluids (Woodbury, N.Y. : 1994) · March 2023 Featured Publication Recent studies indicate that cavitation may play a vital role in laser lithotripsy. However, the underlying bubble dynamics and associated damage mechanisms are largely unknown. In this study, we use ultra-high-speed shadowgraph imaging, hydrophone measure ... Full text Open Access Cite

Plasmonic nanorod probes' journey inside plant cells for in vivo SERS sensing and multimodal imaging.

Journal article Nanoscale · March 2023 Featured Publication Nanoparticle-based platforms are gaining strong interest in plant biology and bioenergy research to monitor and control biological processes in whole plants. However, in vivo monitoring of biomolecules using nanoparticles inside plant cells remains ... Full text Cite

High-Speed Photoacoustic Microscopy Captures Processes Within Tissue

Journal article Biophotonics International · March 1, 2023 Featured Publication When Alexander Graham Bell discovered the photoacoustic effect in the 1880s, he might not have envisioned that this technology would ultimately be successfully implemented in biomedical imaging applications such as neuroscience, dermatology, and cancer bio ... Cite

Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT).

Journal article Photoacoustics · February 2023 Featured Publication We present an ischemic stroke study using our newly-developed PAUSAT system that integrates photoacoustic computed tomography (PACT), high-frequency ultrasound imaging, and acoustic angiographic tomography. PAUSAT is capable of three-dimensional (3D) imagi ... Full text Link to item Cite

High-fidelity deep functional photoacoustic tomography enhanced by virtual point sources.

Journal article Photoacoustics · February 2023 Featured Publication Photoacoustic tomography (PAT), a hybrid imaging modality that acoustically detects the optical absorption contrast, is a promising technology for imaging hemodynamic functions in deep tissues far beyond the traditional optical microscopy. However, the mos ... Full text Cite

Deep-tissue SWIR imaging using rationally designed small red-shifted near-infrared fluorescent protein.

Journal article Nat Methods · January 2023 Applying rational design, we developed 17 kDa cyanobacteriochrome-based near-infrared (NIR-I) fluorescent protein, miRFP718nano. miRFP718nano efficiently binds endogenous biliverdin chromophore and brightly fluoresces in mammalian cells and tissues. miRFP7 ... Full text Open Access Link to item Cite

Intraperitoneal administration for sustained photoacoustic contrast agent imaging.

Journal article Photoacoustics · December 2022 Photoacoustic (PA) imaging at 1064 nm in the second near-infrared (NIR-II) has attracted recent attention. We recently reported a surfactant-based formulation of a NIR-II dye (BIBDAH) for NIR-II PA contrast. Here, we investigated BIBDAH as a NIR-II PA cont ... Full text Cite

High-speed wide-field photoacoustic microscopy using a cylindrically focused transparent high-frequency ultrasound transducer.

Journal article Photoacoustics · December 2022 Combining focused optical excitation and high-frequency ultrasound detection, optical-resolution photoacoustic microscopy (OR-PAM) can provide micrometer-level spatial resolution with millimeter-level penetration depth and has been employed in a variety of ... Full text Link to item Cite

Glassfrogs conceal blood in their liver to maintain transparency.

Journal article Science (New York, N.Y.) · December 2022 Transparency in animals is a complex form of camouflage involving mechanisms that reduce light scattering and absorption throughout the organism. In vertebrates, attaining transparency is difficult because their circulatory system is full of red blood cell ... Full text Cite

Zero-Dimensional Cs3BiX6 (X = Br, Cl) Single Crystal Films with Second Harmonic Generation.

Journal article Nanoscale research letters · December 2022 The development of atomically thin single crystal films is necessary to potential applications in the 2D semiconductor field, and it is significant to explore new physical properties in low-dimensional semiconductors. Since, zero-dimensional (0D) materials ... Full text Cite

Three-Dimensional Deep-Tissue Functional and Molecular Imaging by Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT).

Journal article IEEE Trans Med Imaging · October 2022 Featured Publication Non-invasive small-animal imaging technologies, such as optical imaging, magnetic resonance imaging and x -ray computed tomography, have enabled researchers to study normal biological phenomena or disease progression in their native conditions. However, ex ... Full text Link to item Cite

Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators.

Journal article Journal of biomedical optics · September 2022 SignificanceOptical imaging of responses in fluorescently labeled neurons has progressed significantly in recent years. However, there is still a need to monitor neural activities at divergent spatial scales and at depths beyond the optical diffus ... Full text Cite

The Effects of Scanning Speed and Standoff Distance of the Fiber on Dusting Efficiency during Short Pulse Holmium: YAG Laser Lithotripsy.

Journal article J Clin Med · August 28, 2022 Featured Publication To investigate the effects of fiber lateral scanning speed across the stone surface (vfiber) and fiber standoff distance (SD) on dusting efficiency during short pulse holmium (Ho): YAG laser lithotripsy (LL), pre-soaked BegoStone samples were treated in wa ... Full text Link to item Cite

Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy.

Journal article Light Sci Appl · May 17, 2022 High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular research. High imaging speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks, an ... Full text Open Access Link to item Cite

Deep-E: A Fully-Dense Neural Network for Improving the Elevation Resolution in Linear-Array-Based Photoacoustic Tomography.

Journal article IEEE transactions on medical imaging · May 2022 Featured Publication Linear-array-based photoacoustic tomography has shown broad applications in biomedical research and preclinical imaging. However, the elevational resolution of a linear array is fundamentally limited due to the weak cylindrical focus of the transducer elem ... Full text Cite

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.

Journal article Biomedical engineering letters · May 2022 Featured Publication Venous thromboembolism (VTE) is a condition in which blood clots form within the deep veins of the leg or pelvis to cause deep vein thrombosis. The optimal treatment of VTE is determined by thrombus properties such as the age, size, and chemical compositio ... Full text Cite

Optogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model.

Journal article Nature communications · May 2022 Featured Publication Optogenetic manipulation and optical imaging in the near-infrared range allow non-invasive light-control and readout of cellular and organismal processes in deep tissues in vivo. Here, we exploit the advantages of Rhodopseudomonas palustris BphP1 bacterial ... Full text Cite

Joint mobilization for frozen shoulder: A protocol for systematic review and meta-analysis.

Journal article Medicine · April 2022 BackgroundThe purpose of this study was to evaluate the effectiveness and safety of Joint mobilization in the treatment of frozen shoulder.MethodsTo collect relevant literature, we will research following databases: Medicine, PubMed, Emba ... Full text Cite

Curative efficiency and adverse events of alternative therapy and medicine for functional constipation in adults: A protocol for systematic review and meta-analysis.

Journal article Medicine · April 2022 BackgroundThe efficacy of alternative therapies and medications for functional constipation (FC) in adults is well established, however, the efficacy and safety of different alternative therapies and medications for FC in adults is not fully clari ... Full text Cite

Detection of weak optical absorption by optical-resolution photoacoustic microscopy.

Journal article Photoacoustics · March 2022 Featured Publication Optical-resolution photoacoustic microscopy (OR-PAM) is one of the major implementations of photoacoustic (PA) imaging. With tightly focused optical illumination and high-frequency ultrasound detection, OR-PAM provides micrometer-level resolutions as well ... Full text Cite

Effectiveness and safety of aromatherapy massage for knee osteoarthritis: A protocol for systematic review and meta-analysis.

Journal article Medicine · March 2022 BackgroundThe purpose of this study was to evaluate the effectiveness and safety of aromatherapy massage in the treatment of knee osteoarthritis.MethodsTo collect relevant literature, we will research following databases: PubMed, Web of S ... Full text Cite

Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance.

Journal article Cell death & disease · March 2022 Nonalcoholic fatty liver disease (NAFLD) is closely associated with insulin resistance (IR) and type 2 diabetes mellitus (T2DM), which are all complex metabolic disorders. Selenoprotein S (SelS) is an endoplasmic reticulum (ER) resident selenoprotein invol ... Full text Cite

Acupuncture and massage combined with rehabilitation therapy for hemiplegia after stroke: A protocol for systematic review and meta-analysis.

Journal article Medicine · February 2022 BackgroundThe purpose of this study was to evaluate the effectiveness and safety of acupuncture and massage combined with rehabilitation in the treatment of hemiplegia after stroke.MethodsTo collect relevant literature, we will research f ... Full text Cite

Photoacoustic imaging of 3D-printed vascular networks.

Journal article Biofabrication · January 2022 Thrombosis in the circulation system can lead to major myocardial infarction and cardiovascular deaths. Understanding thrombosis formation is necessary for developing safe and effective treatments. In this work, using digital light processing (DLP)-based 3 ... Full text Cite

Editorial: Advances in Photoacoustic Neuroimaging.

Journal article Frontiers in neuroscience · January 2022 Featured Publication Full text Cite

Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.

Journal article Front Neurosci · 2022 Acoustically detecting the optical absorption contrast, photoacoustic imaging (PAI) is a highly versatile imaging modality that can provide anatomical, functional, molecular, and metabolic information of biological tissues. PAI is highly scalable and can p ... Full text Open Access Link to item Cite

High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator.

Journal article BME frontiers · January 2022 3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors wi ... Full text Cite

High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner.

Journal article Photoacoustics · December 2021 Optical-resolution photoacoustic microscopy (OR-PAM) can provide functional, anatomical, and molecular images at micrometer level resolution with an imaging depth of less than 1 mm in tissue. However, the imaging speed of traditional OR-PAM is often low du ... Full text Link to item Cite

Selenoprotein S attenuates high glucose and/or ox-LDL-induced endothelium injury by regulating Akt/mTOR signaling and autophagy.

Journal article The international journal of biochemistry & cell biology · December 2021 Glucolipid metabolism disorder in diabetes mellitus (DM) causes human endothelial injury and autophagy dysfunction is an important cause of endothelial dysfunction (ED). Selenoprotein S (SelS) could protect endothelium from oxidative stress, inflammatory r ... Full text Cite

Sub-Nanometer Thick Wafer-Size NiO Films with Room-Temperature Ferromagnetic Behavior.

Journal article Angewandte Chemie (International ed. in English) · November 2021 Adding ferromagnetism into semiconductors attracts much attentions due to its potential usage of magnetic spins in novel devices, such as spin field-effect transistors. However, it remains challenging to stabilize their ferromagnetism above room temperatur ... Full text Cite

Photoacoustic computed tomography of mechanical HIFU-induced vascular injury.

Journal article Biomedical optics express · September 2021 Mechanical high-intensity focused ultrasound (HIFU) has been used for cancer treatment and drug delivery. Existing monitoring methods for mechanical HIFU therapies such as MRI and ultrasound imaging often suffer from high cost, poor spatial-temporal resolu ... Full text Cite

Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond.

Journal article JID innovations : skin science from molecules to population health · September 2021 Skin diseases are the most common human diseases and manifest in distinct structural and functional changes to skin tissue components such as basal cells, vasculature, and pigmentation. Although biopsy is the standard practice for skin disease diagnosis, i ... Full text Cite

Effects of transcranial direct current stimulation on experimental pain perception: A systematic review and meta-analysis.

Journal article Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · September 2021 ObjectiveMany studies have examined the effectiveness of transcranial direct current stimulation (tDCS) on human pain perception in both healthy populations and pain patients. Nevertheless, studies have yielded conflicting results, likely due to d ... Full text Cite

Handheld bioprinting strategies for in situ wound dressing.

Journal article Essays in biochemistry · August 2021 Handheld bioprinting has recently attracted considerable attention as a technology to deliver biomaterials and/or cells to injury sites by using freeform, user-instructed deposition approaches, specifically targeted towards in situ wound dressing and heali ... Full text Cite

Time-Resolved Passive Cavitation Mapping Using the Transient Angular Spectrum Approach.

Journal article IEEE transactions on ultrasonics, ferroelectrics, and frequency control · July 2021 Featured Publication Passive cavitation mapping (PCM), which generates images using bubble acoustic emission signals, has been increasingly used for monitoring and guiding focused ultrasound surgery (FUS). PCM can be used as an adjunct to magnetic resonance imaging to provide ... Full text Cite

Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.

Journal article J Biophotonics · July 2021 Featured Publication The in vivo hemodynamic impact of sodium nitroprusside (SNP), a widely used antihypertensive agent, has not been well studied. Here, we applied functional optical-resolution photoacoustic microscopy (OR-PAM) to study the hemodynamic responses to SNP in mic ... Full text Open Access Link to item Cite

Structural and Functional Imaging of the Retina in Central Retinal Artery Occlusion - Current Approaches and Future Directions.

Journal article J Stroke Cerebrovasc Dis · July 2021 Central retinal artery occlusion (CRAO) is a form of acute ischemic stroke which affects the retina. Intravenous thrombolysis is emerging as a compelling therapeutic approach. However, it is not known which patients may benefit from this therapy because th ... Full text Link to item Cite

Translational Photoacoustic Imaging for Disease Diagnosis, Monitoring, and Surgical Guidance: introduction to the feature issue.

Journal article Biomedical optics express · July 2021 This feature issue of Biomedical Optics Express covered all aspects of translational photoacoustic research. Application areas include screening and diagnosis of diseases, imaging of disease progression and therapeutic response, and image-guided tre ... Full text Cite

Deep image prior for undersampling high-speed photoacoustic microscopy.

Journal article Photoacoustics · June 2021 Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e., undersampling) for i ... Full text Open Access Cite

Sounding out the hidden data: A concise review of deep learning in photoacoustic imaging.

Journal article Experimental biology and medicine (Maywood, N.J.) · June 2021 The rapidly evolving field of photoacoustic tomography utilizes endogenous chromophores to extract both functional and structural information from deep within tissues. It is this power to perform precise quantitative measurements in vivo-with endoge ... Full text Cite

Deep image prior for undersampling high-speed photoacoustic microscopy

Journal article Photoacoustics · June 1, 2021 Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e., undersampling) for increase ... Full text Cite

Perspective on fast-evolving photoacoustic tomography.

Journal article Journal of biomedical optics · June 2021 SignificanceAcoustically detecting the rich optical absorption contrast in biological tissues, photoacoustic tomography (PAT) seamlessly bridges the functional and molecular sensitivity of optical excitation with the deep penetration and high scal ... Full text Cite

Instant Ultrasound-Evoked Precise Nanobubble Explosion and Deep Photodynamic Therapy for Tumors Guided by Molecular Imaging.

Journal article ACS applied materials & interfaces · May 2021 Nanobubbles (NBs) have recently gained interest in cancer imaging and therapy due to the fact that nanoparticles with the size range of 1-1000 nm can extravasate into permeable tumor types through the enhanced permeability and retention (EPR) effect. Howev ... Full text Cite

Microglial Exosome miR-7239-3p Promotes Glioma Progression by Regulating Circadian Genes.

Journal article Neuroscience bulletin · April 2021 Glioma-associated microglial cells, a key component of the tumor microenvironment, play an important role in glioma progression. In this study, the mouse glioma cell line GL261 and the mouse microglia cell line BV2 were chosen. First, circadian gene expres ... Full text Cite

A near-infrared genetically encoded calcium indicator for in vivo imaging.

Journal article Nat Biotechnol · March 2021 While calcium imaging has become a mainstay of modern neuroscience, the spectral properties of current fluorescent calcium indicators limit deep-tissue imaging as well as simultaneous use with other probes. Using two monomeric near-infrared (NIR) fluoresce ... Full text Link to item Cite

3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic computed tomography.

Journal article Quantitative imaging in medicine and surgery · March 2021 Featured Publication BackgroundPhotoacoustic computed tomography (PACT) detects light-induced ultrasound (US) waves to reconstruct the optical absorption contrast of the biological tissues. Due to its relatively deep penetration (several centimeters in soft tissue), h ... Full text Cite

Acoustic impact of the human skull on transcranial photoacoustic imaging.

Journal article Biomedical optics express · March 2021 With balanced spatial resolution, imaging depth, and functional sensitivity, photoacoustic tomography (PAT) hold great promise for human brain imaging. However, the strong acoustic attenuation and aberration of the human skull (∼8 mm thick) are longstandin ... Full text Cite

Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning.

Journal article IEEE transactions on medical imaging · February 2021 Featured Publication One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct undersampled PAM images and ... Full text Cite

Tri-modality cavitation mapping in shock wave lithotripsy.

Journal article The Journal of the Acoustical Society of America · February 2021 Featured Publication Shock wave lithotripsy (SWL) has been widely used for non-invasive treatment of kidney stones. Cavitation plays an important role in stone fragmentation, yet it may also contribute to renal injury during SWL. It is therefore crucial to determine the spatio ... Full text Cite

Functionalization induced quantum spin Hall to quantum anomalous Hall phase transition in monolayer jacutingaite.

Journal article Nanoscale · February 2021 As novel states of quantum matter, quantum spin Hall (QSH) and quantum anomalous Hall (QAH) states have attracted considerable interest in condensed matter and materials science communities. Recently, a monolayer of the naturally occurring mineral jacuting ... Full text Cite

Internal-Illumination Photoacoustic Tomography Enhanced by a Graded-Scattering Fiber Diffuser.

Journal article IEEE transactions on medical imaging · January 2021 Featured Publication The penetration depth of photoacoustic imaging in biological tissues has been fundamentally limited by the strong optical attenuation when light is delivered externally through the tissue surface. To address this issue, we previously reported internal-illu ... Full text Cite

Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning.

Journal article IEEE Trans. Medical Imaging · 2021 Featured Publication Full text Cite

Wafer-sized 2D perovskite single crystal thin films for UV photodetectors

Journal article Journal of Materials Chemistry C · 2021 A gas–liquid interface crystalline route to grow a BA 2 PbBr 4 single crystal film (wafer sized (38 cm 2< ... Full text Cite

A large scaled-up monocrystalline 3R MoS 2 electrocatalyst for efficient nitrogen reduction reactions

Journal article New Journal of Chemistry · 2021 Large-scale 3R MoS 2 was shown to be an efficient electrocatalyst for the NRR, and the NRR performance can be enhanced via i ... Full text Cite

PdAg Nanoparticles with Different Sizes: Facile One-Step Synthesis and High Electrocatalytic Activity for Formic Acid Oxidation.

Journal article Chemistry, an Asian journal · January 2021 Recently, direct formic acid fuel cells (DFAFCs) which possess superior advantages such as a low operating temperature, light environmental pollution and high energy density, have been considered as one of the power generation technologies with a bright pr ... Full text Cite

Quadrupole topological phase and robust corner resonance in Kekulé hexagonal electric circuit

Journal article New Journal of Physics · September 1, 2020 AbstractTwo-dimensional (2D) quadrupole topological insulators, featured by topologically protected 0D corner modes, have recently attracted tremendous interest in condensed matter and materials physics. Her ... Full text Cite

Selenoprotein S attenuates endothelial dysfunction in a diabetic vascular chip.

Journal article Experimental gerontology · August 2020 Endothelial dysfunction (ED) is a critical and initiating factor in the genesis of diabetic vascular complications whose occurrence and development is closely related to the complex intravascular microenvironment. However, currently, there is no dynamic mo ... Full text Cite

A generative adversarial network for artifact removal in photoacoustic computed tomography with a linear-array transducer.

Journal article Experimental biology and medicine (Maywood, N.J.) · April 2020 Featured Publication Full text Cite

Snapshot Photoacoustic Topography Through an Ergodic Relay for High-throughput Imaging of Optical Absorption.

Journal article Nature photonics · March 2020 Featured Publication Current embodiments of photoacoustic imaging require either serial detection with a single-element ultrasonic transducer or parallel detection with an ultrasonic array, necessitating a trade-off between cost and throughput. Here, we present photoacoustic t ... Full text Cite

Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway.

Journal article The Journal of endocrinology · March 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1α)-X-box-binding protein 1 (XBP1) pathway is involved. Selenoprotein S (SelS), which is an ER resident selenoprotein ... Full text Cite

Circadian learning and memory changes in Aβ1-42 induced Alzheimer's mice.

Journal article Metabolic brain disease · March 2020 Alzheimer disease (AD) is a growing health problem globally, which causes a progressive decline in learning and memory and multiple disturbances of circadian rhythms. Six Alzheimer's mice and six wild type (WT) mice were involved in this study. Morris Wate ... Full text Cite

Simultaneous Photoacoustic Imaging and Cavitation Mapping in Shockwave Lithotripsy.

Journal article IEEE transactions on medical imaging · February 2020 Featured Publication Kidney stone disease is a major health problem worldwide. Shockwave lithotripsy (SWL), which uses high-energy shockwave pulses to break up kidney stones, is extensively used in clinic. However, despite its noninvasiveness, SWL can produce cavitation in viv ... Full text Cite

EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis.

Journal article PloS one · January 2020 Featured Publication BackgroundShort bowel syndrome (SBS) results from significant loss of small intestinal length. In response to this loss, adaptation occurs, with Epidermal Growth Factor Receptor (EGFR) being a key driver. Besides enhanced enterocyte proliferation, ... Full text Cite

From Light to Sound: Photoacoustic and Ultrasound Imaging in Fundamental Research of Alzheimer's Disease.

Journal article OBM neurobiology · January 2020 Featured Publication Alzheimer's disease (AD) causes severe cognitive dysfunction and has long been studied for the underlining physiological and pathological mechanisms. Several biomedical imaging modalities have been applied, including MRI, PET, and high-resolution optical m ... Full text Cite

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths.

Journal article Molecular imaging · January 2020 Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissu ... Full text Cite

Multi-shell Hollow FeP Microspheres as Efficient Electrocatalyst for Hydrogen Evolution at All pH Values

Journal article CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE · November 10, 2019 Full text Link to item Cite

Listening to tissues with new light: recent technological advances in photoacoustic imaging.

Journal article Journal of optics (2010) · October 2019 Featured Publication Photoacoustic tomography (PAT), or optoacoustic tomography, has achieved remarkable progress in the past decade, benefiting from the joint developments in optics, acoustics, chemistry, computing and mathematics. Unlike pure optical or ultrasound imaging, P ... Full text Cite

Simultaneous photoacoustic imaging of intravascular and tissue oxygenation.

Journal article Optics letters · August 2019 Featured Publication Hypoxia, a low tissue oxygenation condition caused by insufficient oxygen supply, leads to potentially irreversible tissue damage, such as brain infarction during stroke. Intravascular oxygenation has long been used by photoacoustic imaging, among other im ... Full text Cite

Nanostructured hexagonal ReO<sub>3</sub> with oxygen vacancies for efficient electrocatalytic hydrogen generation.

Journal article Nanotechnology · August 2019 We report oxygen vacancies (OVs) rich hexagonal ReO3 nanostructured electrocatalysts for efficient hydrogen generation. Through a simple argon plasma exposure, OVs are introduced into the ReO3 nanoparticles (NP) and nanosheets to enha ... Full text Cite

Impacts of the murine skull on high-frequency transcranial photoacoustic brain imaging.

Journal article Journal of biophotonics · July 2019 Featured Publication Non-invasive photoacoustic tomography (PAT) of mouse brains with intact skulls has been a challenge due to the skull's strong acoustic attenuation, aberration, and reverberation, especially in the high-frequency range (>15 MHz). In this paper, we systemati ... Full text Cite

Imaging the aged brain: pertinence and methods.

Journal article Quantitative imaging in medicine and surgery · May 2019 Featured Publication The global population is ageing at an accelerating speed. The ability to perform working memory tasks together with rapid processing becomes increasingly difficult with increases in age. With increasing national average life spans and a rise in the prevale ... Full text Cite

Selenoprotein S protects against high glucose-induced vascular endothelial apoptosis through the PKCβII/JNK/Bcl-2 pathway.

Journal article Journal of cellular biochemistry · May 2019 Vascular endothelial apoptosis is closely associated with the pathogenesis and progression of diabetic macrovascular diseases. Selenoprotein S (SelS) participates in the protection of vascular endothelial and smooth muscle cells from oxidative and endoplas ... Full text Cite

Thermal Memory Based Photoacoustic Imaging of Temperature.

Journal article Optica · February 2019 Featured Publication Temperature mapping is essential in many biomedical studies and interventions to precisely control the tissue's thermal conditions for optimal treatment efficiency and minimal side effects. Based on the Grüneisen parameter's temperature dependence, photoac ... Full text Cite

Sulfur‐Doped Rhenium Selenide Vertical Nanosheets: A High‐Performance Electrocatalyst for Hydrogen Evolution

Journal article ChemCatChem · October 9, 2018 AbstractDeveloping highly efficient electrocatalysts for hydrogen generation from water has been a crucial option for future energy conversion and storage. Rhenium dichalcogenides (ReX2, X=S or Se) have ... Full text Cite

High-speed widefield photoacoustic microscopy of small-animal hemodynamics.

Journal article Biomed Opt Express · October 1, 2018 Featured Publication Optical-resolution photoacoustic microscopy (OR-PAM) has become a popular tool in small-animal hemodynamic studies. However, previous OR-PAM techniques variously lacked a high imaging speed and/or a large field of view, impeding the study of highly dynamic ... Full text Open Access Link to item Cite

Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy.

Journal article Optics letters · September 2018 Featured Publication Acoustic-resolution photoacoustic microscopy (AR-PAM) can provide penetration depths beyond the optical diffusion limit, but its lateral resolution is typically much worse than its axial resolution, resulting in a low-resolution isotropy. We herein present ... Full text Cite

Advances in super-resolution photoacoustic imaging.

Journal article Quantitative imaging in medicine and surgery · September 2018 Featured Publication Full text Cite

Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer.

Journal article Visual computing for industry, biomedicine, and art · September 2018 Simultaneous photoacoustic and ultrasound (PAUS) imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of tissue. However, the resolution for majority of the existing PAUS systems is on the order o ... Full text Cite

Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

Journal article Biochemical and biophysical research communications · September 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protei ... Full text Cite

Recent progress in photoacoustic molecular imaging.

Journal article Current opinion in chemical biology · August 2018 By acoustically detecting the optical absorption contrast, photoacoustic (PA) tomography (PAT) has broken the penetration limits of traditional high-resolution optical imaging. Through spectroscopic analysis of the target's optical absorption, PAT can iden ... Full text Cite

Quad-mode functional and molecular photoacoustic microscopy.

Journal article Scientific reports · July 2018 Featured Publication A conventional photoacoustic microscopy (PAM) system typically has to make tradeoffs between its spatial resolution and penetration depth, by choosing a fixed configuration of optical excitation and acoustic detection. The single-scale imaging capability o ... Full text Cite

Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo.

Journal article Nature communications · July 2018 Featured Publication Photoacoustic (PA) computed tomography (PACT) benefits from genetically encoded probes with photochromic behavior, which dramatically increase detection sensitivity and specificity through photoswitching and differential imaging. Starting with a DrBphP bac ... Full text Cite

Photoacoustic tomography of blood oxygenation: A mini review.

Journal article Photoacoustics · June 2018 Photoacoustic tomography (PAT) is a hybrid imaging modality that combines rich contrast of optical excitation and deep penetration of ultrasound detection. With its unique optical absorption contrast mechanism, PAT is inherently sensitive to the functional ... Full text Cite

Photoacoustic microscopy: principles and biomedical applications.

Journal article Biomedical engineering letters · May 2018 Photoacoustic microscopy (PAM) has become an increasingly popular technology for biomedical applications, providing anatomical, functional, and molecular information. In this concise review, we first introduce the basic principles and typical system design ... Full text Cite

Imaging Biomaterial-Tissue Interactions.

Journal article Trends in biotechnology · April 2018 Modern biomedical imaging has revolutionized life science by providing anatomical, functional, and molecular information of biological species with high spatial resolution, deep penetration, enhanced temporal responsiveness, and improved chemical specifici ... Full text Cite

Dichroism-sensitive photoacoustic computed tomography.

Journal article Optica · April 2018 Photoacoustic computed tomography (PACT), a fast-developing modality for deep tissue imaging, images the spatial distribution of optical absorption. PACT usually treats the absorption coefficient as a scalar. However, the absorption coefficients of many bi ... Full text Cite

Internal-illumination photoacoustic computed tomography.

Journal article Journal of biomedical optics · March 2018 We report a photoacoustic computed tomography (PACT) system using a customized optical fiber with a cylindrical diffuser to internally illuminate deep targets. The traditional external light illumination in PACT usually limits the penetration depth to a fe ... Full text Cite

Correcting the limited view in optical-resolution photoacoustic microscopy.

Journal article Journal of biophotonics · February 2018 Featured Publication Optical-resolution photoacoustic microscopy (OR-PAM) has proven useful for anatomical and functional imaging with high spatial resolutions. However, the coherent signal generation and the desired reflection-mode detection in OR-PAM can result in a limited ... Full text Cite

Deep-tissue temperature mapping by multi-illumination photoacoustic tomography aided by a diffusion optical model: a numerical study.

Journal article Journal of biomedical optics · January 2018 Temperature mapping during thermotherapy can help precisely control the heating process, both temporally and spatially, to efficiently kill the tumor cells and prevent the healthy tissues from heating damage. Photoacoustic tomography (PAT) has been used fo ... Full text Cite

From bench to market: commercialization of photoacoustic imaging

Journal article Hongwai Yu Jiguang Gongcheng Infrared and Laser Engineering · November 25, 2017 Photoacoustic imaging (PAI) or optoacoustic imaging, the modern application of an ancient physical discovery to biomedical imaging, is without doubt one of the most exciting imaging technologies that has drawn increasing attention from biomedical specialis ... Full text Cite

Photoacoustic thermal flowmetry with a single light source.

Journal article Journal of biomedical optics · September 2017 Featured Publication We report a photoacoustic thermal flowmetry based on optical-resolution photoacoustic microscopy (OR-PAM) using a single laser source for both thermal tagging and photoacoustic excitation. When an optically absorbing medium is flowing across the optical fo ... Full text Cite

Atherosclerosis associated with dynamic inflammation changes after multifactorial intervention in short-duration type 2 diabetes: A randomized, controlled, 10-year follow-up trial.

Journal article Journal of diabetes and its complications · August 2017 PurposeTo analyze the impact of dynamic changes in inflammation on atherosclerosis in short-duration type 2 diabetes after multifactorial intervention.MethodsIn this randomized controlled study, a total of 150 type 2 diabetes patients who ... Full text Cite

Photoacoustic imaging using genetically encoded reporters: a review.

Journal article Journal of biomedical optics · July 2017 Featured Publication Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin. The use of reporter genes expressing absorbing proteins opens the possibility of visual ... Full text Cite

High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

Journal article Journal of biophotonics · June 2017 We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. ... Full text Cite

When pressure meets light: detecting the photoacoustic effect at the origin.

Journal article Light, science & applications · June 2017 Featured Publication Full text Cite

Displacement of Cryomodule in CADS Injector II

Journal article ATW-INTERNATIONAL JOURNAL FOR NUCLEAR POWER · June 2017 Link to item Cite

Handheld optical-resolution photoacoustic microscopy.

Journal article Journal of biomedical optics · April 2017 Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free Full text Cite

Direct measurement of hypoxia in a xenograft multiple myeloma model by optical-resolution photoacoustic microscopy.

Journal article Cancer biology & therapy · February 2017 Using photoacoustic microscopy (PAM), we evaluated non-invasively oxygenation and vascularization in vivo due to multiple myeloma (MM) progression. Mice injected with MM.1S-GFP were monitored with a fluorescence microscope for tumor progression. In vivo PA ... Full text Cite

Single-impulse Panoramic Photoacoustic Computed Tomography of Small-animal Whole-body Dynamics at High Spatiotemporal Resolution.

Journal article Nature biomedical engineering · January 2017 Featured Publication Imaging of small animals has played an indispensable role in preclinical research by providing high dimensional physiological, pathological, and phenotypic insights with clinical relevance. Yet pure optical imaging suffers from either shallow penetration ( ... Full text Cite

In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells.

Journal article Scientific reports · December 2016 Metastasis causes as many as 90% of cancer-related deaths, especially for the deadliest skin cancer, melanoma. Since hematogenous dissemination of circulating tumor cells is the major route of metastasis, detection and destruction of circulating tumor cell ... Full text Cite

A practical guide to photoacoustic tomography in the life sciences.

Journal article Nature methods · July 2016 Featured Publication The life sciences can benefit greatly from imaging technologies that connect microscopic discoveries with macroscopic observations. One technology uniquely positioned to provide such benefits is photoacoustic tomography (PAT), a sensitive modality for imag ... Full text Open Access Cite

Tutorial on photoacoustic tomography.

Journal article Journal of biomedical optics · June 2016 Featured Publication Photoacoustic tomography (PAT) has become one of the fastest growing fields in biomedical optics. Unlike pure optical imaging, such as confocal microscopy and two-photon microscopy, PAT employs acoustic detection to image optical absorption contrast with h ... Full text Cite

In vivo photoacoustic tomography of myoglobin oxygen saturation.

Journal article Journal of biomedical optics · June 2016 Featured Publication Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography ... Full text Cite

Photoacoustic elastography.

Journal article Optics letters · February 2016 Featured Publication Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoacoustic computed ... Full text Cite

Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe.

Journal article Nature methods · January 2016 Featured Publication Photoacoustic tomography (PAT) of genetically encoded probes allows for imaging of targeted biological processes deep in tissues with high spatial resolution; however, high background signals from blood can limit the achievable detection sensitivity. Here ... Full text Open Access Cite

Multiscale Functional and Molecular Photoacoustic Tomography.

Journal article Ultrasonic imaging · January 2016 Photoacoustic tomography (PAT) combines rich optical absorption contrast with the high spatial resolution of ultrasound at depths in tissue. The high scalability of PAT has enabled anatomical imaging of biological structures ranging from organelles to orga ... Full text Cite

High-speed label-free functional photoacoustic microscopy of mouse brain in action.

Journal article Nature methods · May 2015 Featured Publication We present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimens ... Full text Open Access Cite

Photoacoustic microscopy: superdepth, superresolution, and superb contrast.

Journal article IEEE pulse · May 2015 Featured Publication Since its invention in the 17th century, optical microscopy has revolutionized biomedical studies by scrutinizing the biological realm on cellular levels, taking advantage of its excellent light-focusing capability. However, most biological tissues scatter ... Full text Cite

Optical-resolution photoacoustic endomicroscopy in vivo.

Journal article Biomedical optics express · March 2015 Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments ... Full text Cite

Three-dimensional photoacoustic endoscopic imaging of the rabbit esophagus.

Journal article PloS one · January 2015 We report photoacoustic and ultrasonic endoscopic images of two intact rabbit esophagi. To investigate the esophageal lumen structure and microvasculature, we performed in vivo and ex vivo imaging studies using a 3.8-mm diameter photoacoustic endoscope and ... Full text Cite

Photoacoustic lymphatic imaging with high spatial-temporal resolution.

Journal article Journal of biomedical optics · November 2014 Despite its critical function in coordinating the egress of inflammatory and immune cells out of tissues and maintaining fluid balance, the causative role of lymphatic network dysfunction in pathological settings is still understudied. Engineered-animal mo ... Full text Cite

Near-infrared optical-resolution photoacoustic microscopy.

Journal article Optics letters · September 2014 Compared with visible light (380-700 nm), near-infrared light (700-1400 nm) undergoes weaker optical attenuation in biological tissue; thus, it can penetrate deeper. Herein, we demonstrate near-infrared optical-resolution photoacoustic microscopy (NIR-OR-P ... Full text Cite

Reversibly switchable fluorescence microscopy with enhanced resolution and image contrast.

Journal article Journal of biomedical optics · August 2014 Confocal microscopy with optical sectioning has revolutionized biological studies by providing sharper images than conventional optical microscopy. Here, we introduce a fluorescence imaging method with enhanced resolution and imaging contrast, which can be ... Full text Cite

Optical-resolution photoacoustic microscopy for volumetric and spectral analysis of histological and immunochemical samples.

Journal article Angewandte Chemie (International ed. in English) · July 2014 Optical-resolution photoacoustic microscopy (OR-PAM) is an imaging modality with superb penetration depth and excellent absorption contrast. Here we demonstrate, for the first time, that this technique can advance quantitative analysis of conventional chro ... Full text Cite

In vivo optically encoded photoacoustic flowgraphy.

Journal article Optics letters · July 2014 We present an optically encoded photoacoustic (PA) flow imaging method based on optical-resolution PA microscopy. An intensity-modulated continuous-wave laser photothermally encodes the flowing medium, and a pulsed laser generates PA waves to image the enc ... Full text Cite

Sensitivity of photoacoustic microscopy.

Journal article Photoacoustics · June 2014 Building on its high spatial resolution, deep penetration depth and excellent image contrast, 3D photoacoustic microscopy (PAM) has grown tremendously since its first publication in 2005. Integrating optical excitation and acoustic detection, PAM has broke ... Full text Cite

Photoacoustic Brain Imaging: from Microscopic to Macroscopic Scales.

Journal article Neurophotonics · May 2014 Human brain mapping has become one of the most exciting contemporary research areas, with major breakthroughs expected in the following decades. Modern brain imaging techniques have allowed neuroscientists to gather a wealth of anatomic and functional info ... Full text Cite

Breakthrough in Photonics 2013: Photoacoustic Tomography in Biomedicine.

Journal article IEEE photonics journal · April 2014 Photoacoustic tomography (PAT) is one of the fastest growing biomedical imaging modalities in the last decade. Building on its high scalability and complementary imaging contrast to other mainstream modalities, PAT has gained substantial momentum in both p ... Full text Cite

Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media.

Journal article Journal of biomedical optics · April 2014 We propose a calibration-free photoacoustic (PA) method for transverse flow measurements. In this method, a pulsed periodically structured (i.e., grating patterned) optical beam is used to illuminate flowing absorptive particles in an optically scattering ... Full text Cite

Calibration-free absolute quantification of particle concentration by statistical analyses of photoacoustic signals in vivo.

Journal article Journal of biomedical optics · March 2014 Currently, laser fluence calibration is typically required for quantitative measurement of particle concentration in photoacoustic imaging. Here, we present a calibration-free method to quantify the absolute particle concentration by statistically analyzin ... Full text Cite

Photoacoustic tomography: principles and advances.

Journal article Electromagnetic waves (Cambridge, Mass.) · January 2014 Featured Publication Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophore ... Full text Open Access Cite

Fabrication of Cell Patches Using Biodegradable Scaffolds with a Hexagonal Array of Interconnected Pores (SHAIPs).

Journal article Polymer · January 2014 Cell patches are widely used for healing injuries on the surfaces or interfaces of tissues such as those of epidermis and myocardium. Here we report a novel type of porous scaffolds made of poly(D,L-lactic-co-glycolic acid) for fabricating cell patc ... Full text Cite

Photoimprint photoacoustic microscopy for three-dimensional label-free subdiffraction imaging.

Journal article Physical review letters · January 2014 Subdiffraction optical microscopy allows the imaging of cellular and subcellular structures with a resolution finer than the diffraction limit. Here, combining the absorption-based photoacoustic effect and intensity-dependent photobleaching effect, we demo ... Full text Cite

Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy.

Journal article Angewandte Chemie (International ed. in English) · January 2014 Degradation is among the most important properties of biomaterial scaffolds, which are indispensable for regenerative medicine. The currently used method relies on the measurement of mass loss across different samples and cannot track the degradation of an ... Full text Cite

Absolute photoacoustic thermometry in deep tissue.

Journal article Optics letters · December 2013 Photoacoustic thermography is a promising tool for temperature measurement in deep tissue. Here we propose an absolute temperature measurement method based on the dual temperature dependences of the Grüneisen parameter and the speed of sound in tissue. By ... Full text Cite

Ultrasonically encoded photoacoustic flowgraphy in biological tissue.

Journal article Physical review letters · November 2013 Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded p ... Full text Cite

Ultrasound-heated photoacoustic flowmetry.

Journal article Journal of biomedical optics · November 2013 Featured Publication We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. P ... Full text Cite

Photoacoustic Microscopy.

Journal article Laser & photonics reviews · September 2013 Featured Publication Photoacoustic microscopy (PAM) is a hybrid in vivo imaging technique that acoustically detects optical contrast via the photoacoustic effect. Unlike pure optical microscopic techniques, PAM takes advantage of the weak acoustic scattering in tissue a ... Full text Cite

Structured-illumination photoacoustic Doppler flowmetry of axial flow in homogeneous scattering media.

Journal article Applied physics letters · August 2013 Featured Publication We propose a method for photoacoustic flow measurement based on the Doppler effect from a flowing homogeneous medium. Excited by spatially modulated laser pulses, the flowing medium induces a Doppler frequency shift in the received photoacoustic signals. T ... Full text Cite

Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth.

Journal article Optics letters · July 2013 Featured Publication Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth. To reduce tissue scattering, we propose to use glycerol as an optica ... Full text Cite

Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.

Journal article Journal of pediatric surgery · June 2013 Featured Publication PurposeMassive small bowel resection (SBR) results in an adaptive response within the remnant bowel. We have previously shown an immediate reduction in intestinal blood flow and oxygen saturation (sO2) after SBR. We therefore sought to determine t ... Full text Cite

Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography.

Journal article Tissue engineering. Part C, Methods · March 2013 Featured Publication It is a grand challenge to visualize and assess in vivo neovascularization in a three-dimensional (3D) scaffold noninvasively, together with high spatial resolution and deep penetration depth. Here we used multiscale photoacoustic microscopy (PAM), includi ... Full text Cite

Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo.

Journal article NeuroImage · January 2013 Featured Publication We have demonstrated the feasibility of imaging mouse brain metabolism using photoacoustic computed tomography (PACT), a fast, noninvasive and functional imaging modality with optical contrast and acoustic resolution. Brain responses to forepaw stimulation ... Full text Cite

A water-immersible 2-axis scanning mirror microsystem for ultrasound andha photoacoustic microscopic imaging applications.

Journal article Microsystem technologies : sensors, actuators, systems integration · January 2013 Featured Publication Fast scanning is highly desired for both ultrasound and photoacoustic microscopic imaging, whereas the liquid environment required for acoustic propagation limits the usage of traditional microelectromechanical systems (MEMS) scanning mirrors. Here, a new ... Full text Cite

In vivo photoacoustic microscopy with 7.6-µm axial resolution using a commercial 125-MHz ultrasonic transducer.

Journal article Journal of biomedical optics · November 2012 Featured Publication Photoacoustic microscopy has achieved submicron lateral resolution, but its axial resolution is much lower. Here an axial resolution of 7.6 μm, the highest axial resolution validated by experimental data, has been achieved by using a commercial 125 MHz ult ... Full text Cite

A 2.5-mm diameter probe for photoacoustic and ultrasonic endoscopy.

Journal article Optics express · October 2012 Featured Publication We have created a 2.5-mm outer diameter integrated photo-acoustic and ultrasonic mini-probe which can be inserted into a standard video endoscope's instrument channel. A small-diameter focused ultrasonic transducer made of PMN-PT provides adequate signal s ... Full text Cite

Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror.

Journal article Journal of biomedical optics · August 2012 Featured Publication By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging spe ... Full text Cite

Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo.

Journal article Nature medicine · August 2012 Featured Publication At present, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures that provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high-resolution images, but also is safe for clinical use and ... Full text Cite

In vivo photoacoustic tomography of total blood flow and potential imaging of cancer angiogenesis and hypermetabolism.

Journal article Technology in cancer research & treatment · August 2012 Featured Publication Blood flow is a key parameter in studying cancer angiogenesis and hypermetabolism. Current photoacoustic blood flow estimation methods focus on either the axial or transverse component of the flow vector. However, the Doppler angle (beam-to-flow angle) is ... Full text Cite

Immediate alterations in intestinal oxygen saturation and blood flow after massive small bowel resection as measured by photoacoustic microscopy.

Journal article Journal of pediatric surgery · June 2012 Featured Publication PurposeMassive small bowel resection (SBR) results in villus angiogenesis and a critical adaptation response within the remnant bowel. Previous ex vivo studies of intestinal blood flow after SBR are conflicting. We sought to determine the effect o ... Full text Cite

Functional photoacoustic microscopy of diabetic vasculature.

Journal article Journal of biomedical optics · June 2012 Featured Publication We used functional photoacoustic microscopy to image diabetes-induced damage to the microvasculature. To produce an animal model for Type 1 diabetes, we used streptozotocin (STZ), which is particularly toxic to the insulin-producing beta cells of the pancr ... Full text Cite

Double-illumination photoacoustic microscopy.

Journal article Optics letters · February 2012 Featured Publication Recent developments of optical-resolution photoacoustic microscopy (OR-PAM) have improved its spatial resolution and imaging speed. However, the penetration depth of OR-PAM is still limited to ~1 mm in tissue, owing to the strong tissue scattering. Here, w ... Full text Cite

Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe.

Journal article Angewandte Chemie (International ed. in English) · February 2012 Featured Publication Full text Cite

In vivo imaging of epileptic activity using 2-NBDG, a fluorescent deoxyglucose analog.

Journal article Journal of neuroscience methods · January 2012 Featured Publication Accurately locating epileptic foci has great importance in advancing the treatment of epilepsy. In this study, epileptic seizures were first induced by intracortical injection of 4-aminopyridine in rats. A fluorescent deoxyglucose substitute, 2-(N-(7-nitro ... Full text Cite

Functional photoacoustic microscopy of pH.

Journal article Journal of biomedical optics · October 2011 Featured Publication pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fl ... Full text Cite

Photoacoustic tomography: fundamentals, advances and prospects.

Journal article Contrast media & molecular imaging · September 2011 Featured Publication Optical microscopy has been contributing to the development of life science for more than three centuries. However, due to strong optical scattering in tissue, its in vivo imaging ability has been restricted to studies at superficial depths. Advances in ph ... Full text Cite

Photoacoustic microscopy of tyrosinase reporter gene in vivo.

Journal article Journal of biomedical optics · August 2011 Featured Publication Photoacoustic tomography is a hybrid modality based on optical absorption excitation and ultrasonic detection. It is sensitive to melanin, one of the primary absorbers in skin. For cells that do not naturally contain melanin, melanin production can be indu ... Full text Cite

VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting.

Journal article Proceedings of the National Academy of Sciences of the United States of America · August 2011 Featured Publication Although our understanding of the molecular regulation of adult neovascularization has advanced tremendously, vascular-targeted therapies for tissue ischemia remain suboptimal. The master regulatory transcription factors of the hypoxia-inducible factor (HI ... Full text Cite

Photoacoustic microscopy of microvascular responses to cortical electrical stimulation.

Journal article Journal of biomedical optics · July 2011 Featured Publication Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to ... Full text Cite

Label-free oxygen-metabolic photoacoustic microscopy in vivo.

Journal article Journal of biomedical optics · July 2011 Featured Publication Almost all diseases, especially cancer and diabetes, manifest abnormal oxygen metabolism. Accurately measuring the metabolic rate of oxygen (MRO(2)) can be helpful for fundamental pathophysiological studies, and even early diagnosis and treatment of diseas ... Full text Cite

Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.

Journal article Blood · April 2011 Featured Publication Neovascularization is a crucial component of tumor growth and ischemia. Although prior work primarily used disease models, delineation of neovascularization in the absence of disease can reveal intrinsic mechanisms of microvessel regulation amenable to man ... Full text Cite

Fast voice-coil scanning optical-resolution photoacoustic microscopy.

Journal article Optics letters · January 2011 Featured Publication We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a late ... Full text Cite

In vivo photoacoustic mapping of lymphatic systems with plasmon-resonant nanostars.

Journal article Journal of materials chemistry · January 2011 Featured Publication Plasmon-resonant nanostars (NSTs) provide excellent contrast enhancement for photoacoustic tomography. The high photoacoustic sensitivity of NSTs at near-infrared wavelengths enable their in vivo detection in rat sentinel lymph nodes and vessels, with dire ... Full text Cite

Mouse model to study human A beta2M amyloidosis: generation of a transgenic mouse with excessive expression of human beta2-microglobulin.

Journal article Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · June 2010 Patients on long-term hemodialysis can develop dialysis-related amyloidosis (DRA) due to deposition of beta(2)-microglobulin (beta(2)m) into amyloid fibrils (Abeta(2)M). Despite intensive biochemical studies, the pathogenesis of amyloid deposition in DRA p ... Full text Cite

In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth.

Journal article Optics letters · May 2010 Featured Publication A method is proposed to measure transverse blood flow by using photoacoustic Doppler broadening of bandwidth. By measuring bovine blood flowing through a plastic tube, the linear dependence of the broadening on the flow speed was validated. The blood flow ... Full text Cite

Transverse flow imaging based on photoacoustic Doppler bandwidth broadening.

Journal article Journal of biomedical optics · March 2010 Featured Publication We propose a new method to measure transverse flow velocity based on photoacoustic Doppler bandwidth broadening, which is determined by the geometry of the probe-beam and the velocity of the transverse flow. By exploiting pulsed laser excitation and raster ... Full text Cite

Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo.

Journal article Journal of biomedical optics · September 2009 Featured Publication Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBCs) as an endogenic co ... Full text Cite

Three-dimensional reconstruction for fluorescence tomography using cylinder phantoms

Journal article Ruan Jian Xue Bao Journal of Software · May 1, 2009 Featured Publication Based on the finite element analysis, this study applies three iterative regularization algorithms to the 3D reconstruction of fluorescent yield, including conjugate gradient least square (CGLS), least square QR decomposition (LSQR), and 2-order pre-iterat ... Full text Cite

Modeling and validation of light propagation in free-space for non-contact near-infrared fluorescent tomography

Journal article Hongwai Yu Haomibo Xuebao Journal of Infrared and Millimeter Waves · October 1, 2008 Featured Publication Light propagation from the object boundary to detector was presented for non-contact near infrared fluorescent molecular tomography (FMT). Based on the work of Jorge Ripoll et al, perspective projection effect of lens was considered. The formula for light ... Cite

A 3D-surface torso reconstruction method used in fluorescence molecular tomography of small animals

Journal article Chinese Journal of Biomedical Engineering · June 1, 2008 Featured Publication Objective: The CCD-based non-contact fluorescencemolecular tomography has got a rapid progress in recent years. This imaging modality needs to acquire 3D-surface of the animal imaged, which is used as the forward model in the fluorescence concentration rec ... Cite

Full-angle optical imaging of near-infrared fluorescent probes implanted in small animals

Journal article Progress in Natural Science · January 1, 2008 Featured Publication To provide a valuable experimental platform for in vivo biomedical research of small animal model with fluorescence mediated approach, we developed a whole-body near-infrared fluorescence molecular imaging system as described in this paper. This system is ... Full text Cite