Scholars@Duke
Junqin Chen

Selected Publications

Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles.

Journal Article Adv Sci (Weinh) · December 2025 Urinary stone disease, characterized by the hard mineral deposits in the urinary tract, has seen a rising prevalence globally. This condition often leads to severe pain and requires medical intervention. Laser lithotripsy, a minimally invasive treatment, u ... Full text Open Access Link to item Cite

Three-Dimensional Super-Resolution Passive Cavitation Mapping in Laser Lithotripsy.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · December 2024 Kidney stone disease is a major public health issue. By breaking stones with repeated laser irradiation, laser lithotripsy (LL) has become the main treatment for kidney stone disease. Laser-induced cavitation is closely associated with stone damage in LL. ... Full text Open Access Link to item Cite

Vapour bubbles produced by long-pulsed laser: a race between advection and phase transition.

Journal Article Journal of fluid mechanics · November 2024 Vapor bubbles produced by long-pulsed laser often have complex non-spherical shapes that reflect some characteristics of the laser beam. The transition between two commonly observed shapes - namely, a rounded pear-like shape and an elongated conical shape ... Full text Open Access Cite

Exploring optimal settings for safe and effective thulium fibre laser lithotripsy in a kidney model.

Journal Article BJU Int · February 2024 OBJECTIVES: To explore the optimal laser settings and treatment strategies for thulium fibre laser (TFL) lithotripsy, namely, those with the highest treatment efficiency, lowest thermal injury risk, and shortest procedure time. MATERIALS AND METHODS: An in ... Full text Open Access Link to item Cite

Shock waves generated by toroidal bubble collapse are imperative for kidney stone dusting during Holmium:YAG laser lithotripsy.

Journal Article Ultrasonics sonochemistry · December 2023 Holmium:yttrium-aluminum-garnet (Ho:YAG) laser lithotripsy (LL) has been the treatment of choice for kidney stone disease for more than two decades, yet the mechanisms of action are not completely clear. Besides photothermal ablation, recent evidence sugge ... Full text Cite

In vitro investigation of stone ablation efficiency, char formation, spark generation, and damage mechanism produced by thulium fiber laser.

Journal Article Urolithiasis · November 2, 2023 To investigate stone ablation characteristics of thulium fiber laser (TFL), BegoStone phantoms were spot-treated in water at various fiber tip-to-stone standoff distances (SDs, 0.5 ~ 2 mm) over a broad range of pulse energy (Ep, 0.2 ~ 2 J), frequency (F, 5 ... Full text Open Access Link to item Cite

In Pursuit of the Optimal Dusting Settings with the Thulium Fiber Laser: An In Vitro Assessment.

Journal Article J Endourol · August 2023 Objective: Low energy and high frequency settings are used in stone dusting for holmium lasers. Such settings may not be optimal for thulium fiber laser (TFL). With the seemingly endless combination of settings, we aim to provide guidance to the practicing ... Full text Link to item Cite

Model-based simulations of pulsed laser ablation using an embedded finite element method.

Journal Article International journal of heat and mass transfer · May 2023 A model of thermal ablation with application to multi-pulsed laser lithotripsy is presented. The approach is based on a one-sided Stefan-Signorini model for thermal ablation, and relies on a level-set function to represent the moving interface between the ... Full text Cite

Dissimilar cavitation dynamics and damage patterns produced by parallel fiber alignment to the stone surface in holmium:yttrium aluminum garnet laser lithotripsy.

Journal Article Physics of fluids (Woodbury, N.Y. : 1994) · March 2023 Recent studies indicate that cavitation may play a vital role in laser lithotripsy. However, the underlying bubble dynamics and associated damage mechanisms are largely unknown. In this study, we use ultra-high-speed shadowgraph imaging, hydrophone measure ... Full text Open Access Cite

The Effects of Scanning Speed and Standoff Distance of the Fiber on Dusting Efficiency during Short Pulse Holmium: YAG Laser Lithotripsy.

Journal Article J Clin Med · August 28, 2022 To investigate the effects of fiber lateral scanning speed across the stone surface (vfiber) and fiber standoff distance (SD) on dusting efficiency during short pulse holmium (Ho): YAG laser lithotripsy (LL), pre-soaked BegoStone samples were treated in wa ... Full text Link to item Cite

Cavitation Plays a Vital Role in Stone Dusting During Short Pulse Holmium:YAG Laser Lithotripsy.

Journal Article J Endourol · May 2022 Objective: To investigate the mechanism of stone dusting in Holmium (Ho): YAG laser lithotripsy (LL). Materials and Methods: Cylindrical BegoStone samples (6 × 6 mm, H × D) were treated in water using a clinical Ho:YAG laser lithotripter in dusting mode (0 ... Full text Link to item Cite

The Role of Cavitation in Energy Delivery and Stone Damage During Laser Lithotripsy.

Journal Article J Endourol · June 2021 Purpose: Although cavitation during laser lithotripsy (LL) contributes to the Moses effect, the impact of cavitation on stone damage is less clear. Using different laser settings, we investigate the role of cavitation bubbles in energy delivery and stone d ... Full text Link to item Cite