Scholars@Duke
Junzo Paul Chino

Junzo Paul Chino

Professor of Radiation Oncology
Radiation Oncology
junzo.chino@duke.edu
Box 3085 Med Ctr, Durham, NC 27710
Dept Radiation Oncology, Durham, NC 27710

Scholarly Works - Journal articles

Radiation Quality and Workflow in NRG GY017: Anti-PD-L1 (Atezolizumab) as an Immune Primer or Concurrently With Radiation Therapy for Node-Positive Locally Advanced Cervical Cancer.

Journal article Int J Radiat Oncol Biol Phys · November 1, 2026 OBJECTIVES: Advances in radiation (RT) treatment planning enhance the need for uniform quality oversight on clinical trials. NRG GY-017 was a randomized trial of the anti-program ligand death 1 (PD-L1) antibody, atezolizumab, before and concurrent (arm A) ... Full text Link to item Cite

Design and Implementation of Novel Internal Mini Fellowship Concentrations Within a Radiation Oncology Residency Program.

Journal article Int J Radiat Oncol Biol Phys · August 1, 2026 PURPOSE: Resident and faculty impressions of novel mini fellowship concentrations in multiple disease sites during radiation oncology training were assessed. METHODS AND MATERIALS: In 2022, mini fellowship concentrations in gynecologic brachytherapy, centr ... Full text Link to item Cite

Rapid Artificial Intelligence Autoplanning Rivals Manual Expert Planning for Cervical Brachytherapy.

Journal article Pract Radiat Oncol · May 9, 2026 PURPOSE: The study aims to evaluate the quality and clinical acceptability of artificial intelligence automated plans compared with manual clinical plans through blinded physician review, for cervical brachytherapy applicators. METHODS AND MATERIALS: Autom ... Full text Link to item Cite

Integrating Brachytherapy and Emerging Systemic Therapies Into Cervical Cancer Care

Journal article Jnccn Journal of the National Comprehensive Cancer Network · May 1, 2026 Brachytherapy remains a cornerstone of curative-intent treatment for cervical cancer, with strong evidence supporting its role in improving local control and survival. Advances in image-guided techniques have further enhanced outcomes while reducing toxici ... Full text Cite

Vaginal Cancer, Version 2.2026, NCCN Clinical Practice Guidelines In Oncology.

Journal article J Natl Compr Canc Netw · March 2026 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Vaginal Cancer outline the recommended diagnostic workup, staging considerations, and treatment options for this rare malignancy. Because vaginal cancer is uncommon and shares many bio ... Full text Link to item Cite

Image guided brachytherapy quality assurance on NRG GY017 investigating immunotherapy in addition to chemoradiation for locally advanced cervical cancer.

Journal article Brachytherapy · 2026 INTRODUCTION: Brachytherapy is a critical component of curative treatment in locally advanced cervical cancer. NRG GY-017 is a randomized Phase I trial of the anti-PD-L1 antibody atezolizumab administered neoadjuvantly and concurrently with chemoradiation ... Full text Link to item Cite

Cervical Cancer, Version 2.2026, NCCN Clinical Practice Guidelines In Oncology.

Journal article J Natl Compr Canc Netw · December 2025 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cervical Cancer provide diagnostic workup, staging, and various treatment recommendations for cervical cancer based on clinical and surgical staging. This selection from the NCCN Guide ... Full text Link to item Cite

Fear and Medical Misinformation Regarding Risk of Progression or Recurrence Among Patients with Breast Cancer.

Journal article JAMA Netw Open · December 1, 2025 IMPORTANCE: Misinformation about cancer treatment is increasingly common. It is not known whether exposure to such misinformation is related to fear of cancer recurrence or adherence to evidence-based treatment. OBJECTIVE: To evaluate exposure to misinform ... Full text Link to item Cite

The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2025 PURPOSE: To assess the impact of MLH1 promoter hypermethylation (MLH1ph) on prognosis and define the patterns of recurrence in stage I or II endometroid endometrial cancer (EEC) treated with adjuvant radiation therapy. METHODS AND MATERIALS: In a retrospec ... Full text Link to item Cite

Embracing and implementing the WHO cervical cancer elimination campaign goals: A consensus statement by SGO, ACOG, ASCCP, ASTRO, and ABS on minimum quality care standards for cervical cancer patients in the U.S.

Journal article Gynecol Oncol · September 2025 The World Health Organization (WHO) has clearly published the necessary metrics for elimination of cervical cancer as a public health problem, which includes adequate treatment of both cervical cancer and its precursors for at least 90 % of affected indivi ... Full text Link to item Cite

Minimum standards for radiation therapy in the treatment of cervical cancer in the U.S.: A consensus statement by SGO, ASTRO, and ABS addressing the WHO Cervical Cancer Elimination Campaign goals.

Journal article Gynecol Oncol · September 2025 Cervical cancer remains a significant source of morbidity and mortality worldwide, both in high-income countries such as the United States and in low- and middle-income countries. Access to high quality radiation therapy (RT) is critical for improving outc ... Full text Link to item Cite

NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2025.

Journal article J Natl Compr Canc Netw · August 2025 The NCCN Guidelines for Uterine Neoplasms provide recommendations for diagnostic workup, clinical staging, and treatment options for patients with endometrial cancer and uterine sarcoma. The NCCN Cervical Uterine Panel meets at least annually to review com ... Full text Link to item Cite

Implementation of needle-tracking technology for real-time transrectal ultrasound-guided interstitial gynecological HDR brachytherapy: A feasibility study.

Journal article J Appl Clin Med Phys · June 2025 PURPOSE: To investigate the feasibility of adapting a commercial prostate biopsy system for transrectal ultrasound (TRUS)-guided hybrid gynecological (GYN) high-dose-rate (HDR) brachytherapy (BT). Leveraging 3D-TRUS and MR image fusion, the prototype syste ... Full text Link to item Cite

Recent advances in gynecologic radiation oncology.

Journal article Cancer · May 1, 2025 Significant advances have been made in the treatment of patients with gynecologic malignancies in the past few years. Integration of molecular testing in endometrial cancer now allows for more accurate risk stratification and personalized treatment recomme ... Full text Link to item Cite

Commissioning of the Varian universal interstitial cylinder system for HDR brachytherapy of gynecological cancer.

Journal article J Appl Clin Med Phys · February 2025 PURPOSE: This paper outlines the commissioning of the Varian (VMS, Varian Medical Systems, Palo Alto, CA) Universal Interstitial Cylinder (UIC) applicator set for Ir-192 HDR brachytherapy. The UIC was commissioned for use with CT and MRI and a custom phant ... Full text Link to item Cite

Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial.

Journal article Nat Commun · January 9, 2025 Combined immune checkpoint blockade (ICB) and chemoradiation (CRT) is approved in patients with locally advanced cervical cancer (LACC) but optimal sequencing of CRT and ICB is unknown. NRG-GY017 (NCT03738228) was a randomized phase I trial of atezolizumab ... Full text Link to item Cite

Evaluation of cumulative dose distributions from external beam radiation therapy using CT-to-CBCT deformable image registration (DIR) for cervical cancer patients.

Journal article J Appl Clin Med Phys · January 2025 PURPOSE: To investigate dose differences between the planning CT (pCT) and dose calculated on pre-treatment verification CBCTs using DIR and dose summation for cervical cancer patients. METHODS: Cervical cancer patients treated at our institution with 45 G ... Full text Link to item Cite

Retrospective assessment of HDR brachytherapy dose calculation methods in locally advanced cervical cancer patients: AcurosBV vs. AAPM TG43 formalism.

Journal article J Appl Clin Med Phys · January 2025 PURPOSE: This retrospective analysis was completed to investigate the use of a model-based dose calculation algorithm (MBDCA) AcurosBV, for use in HDR BT treatments for locally advanced cervical cancer treated with tandem and ovoid applicators with interst ... Full text Link to item Cite

Consensus Guidelines for Delineation of Clinical Target Volumes for Intensity Modulated Radiation Therapy for Intact Cervical Cancer: An Update.

Journal article Pract Radiat Oncol · 2025 PURPOSE: Accurate target delineation is essential when using intensity modulated radiation therapy for intact cervical cancer. In 2011, the Radiation Therapy Oncology Group published a consensus guideline using magnetic resonance imaging (MRI). The current ... Full text Link to item Cite

The American Brachytherapy Society (ABS) consensus guidance for hybrid intracavitary interstitial brachytherapy for locally advanced cervical cancer.

Journal article Brachytherapy · 2025 PURPOSE: The purpose of this consensus statement from the American Brachytherapy Society (ABS) is to summarize important considerations for adding interstitial needles to intracavitary implants for cervix cancer brachytherapy. METHODS: A panel of experts i ... Full text Link to item Cite

Joint ABS/GEC-ESTRO Consensus Statement on the objectives of training in brachytherapy for physicians.

Journal article Brachytherapy · 2025 Brachytherapy is an essential skill in the practice of radiation oncology and is an important component of high-quality, full-service radiation oncology departments. With rapidly changing technology, the role of brachytherapy is constantly evolving, but it ... Full text Link to item Cite

Yttrium-90 (90Y) brachytherapy for squamous carcinoma: Treatment of the conjunctiva, cornea, and sclera.

Journal article Am J Ophthalmol Case Rep · December 2024 PURPOSE: Patients with conjunctival squamous cell carcinoma that present with persisting disease or recurrence following topical chemotherapy and/or surgery especially when invading the sclera are challenging to treat. Herein, we describe the use of high-d ... Full text Link to item Cite

Prognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2024 PURPOSE: The aim of this work was to report the effect of mismatch repair (MMR) status on outcomes of patients with stage I-II endometrioid endometrial adenocarcinoma (EEC) who receive adjuvant radiation therapy. METHODS AND MATERIALS: This is a multi-inst ... Full text Link to item Cite

Quantification of the environmental impact of radiotherapy and associated secondary human health effects: a multi-institutional retrospective analysis and simulation.

Journal article Lancet Oncol · June 2024 BACKGROUND: The health-care industry is a substantial contributor to global greenhouse gas emissions, yet the specific environmental impact of radiotherapy, a cornerstone of cancer treatment, remains under-explored. We aimed to quantify the emissions assoc ... Full text Link to item Cite

Moving Toward Personalized Medicine in Gynecologic Cancers.

Journal article Int J Radiat Oncol Biol Phys · May 1, 2024 Full text Link to item Cite

Combinatorial Approaches for Chemotherapies and Targeted Therapies With Radiation: United Efforts to Innovate in Patient Care.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2024 Combinatorial therapies consisting of radiation therapy (RT) with systemic therapies, particularly chemotherapy and targeted therapies, have moved the needle to augment disease control across nearly all disease sites for locally advanced disease. Evaluatin ... Full text Link to item Cite

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.

Journal article J Natl Compr Canc Netw · March 2024 Vulvar cancer is annually diagnosed in an estimated 6,470 individuals and the vast majority are histologically squamous cell carcinomas. Vulvar cancer accounts for 5% to 8% of gynecologic malignancies. Known risk factors for vulvar cancer include increasin ... Full text Link to item Cite

Tipping the Balance: Adding Resources for Cervical Cancer Brachytherapy.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2023 Full text Link to item Cite

NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024.

Journal article J Natl Compr Canc Netw · December 2023 The NCCN Guidelines for Cervical Cancer provide recommendations for all aspects of management for cervical cancer, including the diagnostic workup, staging, pathology, and treatment. The guidelines also include details on histopathologic classification of ... Full text Link to item Cite

A novel multi-modality imaging phantom for validating interstitial needle guidance for high dose rate gynecological brachytherapy.

Journal article J Appl Clin Med Phys · October 2023 PURPOSE: To design, manufacture, and validate a female pelvic phantom for multi-modality imaging (CT, MRI, US) to benchmark a commercial needle tracking system with application in HDR gynecological (GYN) interstitial procedures. MATERIALS AND METHODS: A GY ... Full text Open Access Link to item Cite

Pivotal Science From the 2022 International Gynecologic Cancer Society Meeting

Journal article International Journal of Radiation Oncology Biology Physics · July 1, 2023 Full text Cite

The Affordable Care Act and suicide incidence among adults with cancer.

Journal article J Cancer Surviv · April 2023 BACKGROUND: Patients with cancer are at an increased suicide risk, and socioeconomic deprivation may further exacerbate that risk. The Affordable Care Act (ACA) expanded insurance coverage options for low-income individuals and mandated coverage of mental ... Full text Link to item Cite

Insurance Coverage and Forgoing Medical Appointments Because of Cost Among Cancer Survivors After 2016.

Journal article JCO Oncol Pract · April 2023 PURPOSE: The uninsured rate began rising after 2016, which some have attributed to health policies undermining aspects of the Affordable Care Act. Our primary objectives were to assess the changes in insurance coverage and forgoing medical care because of ... Full text Link to item Cite

The Impact of Racial Disparities on Outcome in Patients With Stage IIIC Endometrial Carcinoma: A Pooled Data Analysis.

Journal article Am J Clin Oncol · March 1, 2023 OBJECTIVE: To report the impact of race on clinical outcomes in patients with stage IIIC endometrial carcinoma. MATERIALS AND METHODS: A retrospective multi-institutional study included 90 black and 568 non-black patients with stage IIIC endometrial carcin ... Full text Link to item Cite

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.

Journal article J Natl Compr Canc Netw · February 2023 Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the female genital tract in the United States. It is estimated that 65,950 new uteri ... Full text Link to item Cite

What is appropriate target delineation for MRI-based brachytherapy for medically inoperable endometrial cancer?

Journal article Brachytherapy · 2023 PURPOSE: For medically inoperable endometrial cancer (MIEC), the volumetric target of image-guided brachytherapy (IGBT) techniques is not well established. We propose a high-risk CTV (HRCTV) concept and report associated rates of local control and toxicity ... Full text Link to item Cite

Estimating Carbon Dioxide Emissions and Direct Power Consumption of Linear Accelerator-Based External Beam Radiation Therapy.

Journal article Adv Radiat Oncol · 2023 PURPOSE: Climate change is one of the direst health threats that humanity faces. We aim to estimate the carbon dioxide (CO2) emissions associated with the energy usage from linear accelerator (LINAC)-based external beam radiation therapy (EBRT) for the mos ... Full text Link to item Cite

Adaptive Positron Emission Tomography Radiation Therapy in Patients With Locally Advanced Vulvar Cancer: A Prospective Study.

Journal article Adv Radiat Oncol · 2023 PURPOSE: In this prospective trial, we aim to determine whether fluorodeoxyglucose positron emission tomography and computed tomography (PET/CT)-based adaptive radiation therapy (ART) improves dosimetry outcomes for patients treated with definitive radiati ... Full text Link to item Cite

The American Brachytherapy Society and Indian Brachytherapy Society consensus statement for the establishment of high-dose-rate brachytherapy programs for gynecological malignancies in low- and middle-income countries.

Journal article Brachytherapy · 2023 PURPOSE: The global cervical cancer burden is disproportionately high in low- and middle-income countries (LMICs), and outcomes can be governed by the accessibility of appropriate screening and treatment. High-dose-rate (HDR) brachytherapy plays a central ... Full text Link to item Cite

Disparities in place of death for patients with primary brain tumors and brain metastases in the USA.

Journal article Support Care Cancer · August 2022 PURPOSE: Patients with primary or metastatic brain tumors often require intensive end-of-life care, for which place of death may serve as a quality metric. Death at home or hospice is considered a more "ideal" location. Comprehensive information on place o ... Full text Link to item Cite

Treatment of cervical cancer: overcoming challenges in access to brachytherapy.

Journal article Expert Rev Anticancer Ther · April 2022 INTRODUCTION: Brachytherapy is an essential component of the cervical cancer treatment paradigm as it contributes to improved clinical outcomes and overall survival. Yet brachytherapy remains globally underutilized, with disparities in access at both natio ... Full text Link to item Cite

Improving Radiation Therapy for Cervical Cancer.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2022 Full text Link to item Cite

Catastrophic health expenditures, insurance churn, and nonemployment among gynecologic cancer patients in the United States.

Journal article Am J Obstet Gynecol · March 2022 BACKGROUND: In recent years, there has been growing recognition of the financial burden of severe illness, including associations with higher rates of nonemployment, uninsurance, and catastrophic out-of-pocket health spending. Patients with gynecologic can ... Full text Link to item Cite

Role of stereotactic body radiotherapy in gynecologic radiation oncology.

Journal article Int J Gynecol Cancer · March 2022 Stereotactic body radiotherapy (SBRT, also referred to as stereotactic ablative radiotherapy (SABR)) has been used in the treatment of primary and metastatic solid tumors, and increasingly so in gynecologic oncology. This review article aims to summarize t ... Full text Link to item Cite

Does Prophylactic Paraortic Lymph Node Irradiation Improve Outcomes in Women With Stage IIIC1 Endometrial Carcinoma?

Journal article Pract Radiat Oncol · 2022 PURPOSE: To evaluate the impact of prophylactic paraortic lymph node (PALN) radiation therapy (RT) on clinical outcomes in patients with International Federation of Obstetrics and Gynecology 2018 stage IIIC1 endometrial cancer (EC). METHODS AND MATERIALS: ... Full text Link to item Cite

Associations of Insurance Churn and Catastrophic Health Expenditures With Implementation of the Affordable Care Act Among Nonelderly Patients With Cancer in the United States.

Journal article JAMA Netw Open · September 1, 2021 IMPORTANCE: Health insurance coverage is dynamic in the United States, potentially changing from month to month. The Patient Protection and Affordable Care Act (ACA) aimed to stabilize markets and reduce financial burden, particularly among those with pree ... Full text Link to item Cite

A Multi-Institutional Analysis of Adjuvant Chemotherapy and Radiation Sequence in Women With Stage IIIC Endometrial Cancer.

Journal article Int J Radiat Oncol Biol Phys · August 1, 2021 PURPOSE: Our purpose was to evaluate the effect of sequence and type of adjuvant therapy for patients with stage IIIC endometrial carcinoma (EC) on outcomes. METHODS AND MATERIALS: In a multi-institutional retrospective cohort study, patients with stage II ... Full text Link to item Cite

Medicaid Expansion Reduced Uninsured Surgical Hospitalizations And Associated Catastrophic Financial Burden.

Journal article Health Aff (Millwood) · August 2021 An important function of health insurance is protecting enrollees from excessively burdensome charges for unanticipated medical events. Unexpected surgery can be financially catastrophic for uninsured people. By targeting the low-income uninsured populatio ... Full text Link to item Cite

NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2021.

Journal article J Natl Compr Canc Netw · August 1, 2021 The NCCN Guidelines for Uterine Neoplasms provide recommendations for diagnostic workup, clinical staging, and treatment options for patients with endometrial cancer or uterine sarcoma. These NCCN Guidelines Insights focus on the recent addition of molecul ... Full text Link to item Cite

Evaluation of eddy current distortion and field inhomogeneity distortion corrections in MR diffusion imaging using log-demons DIR method.

Journal article Phys Med Biol · January 29, 2021 To investigate the feasibility of the log-demons deformable image registration (DIR) method to correct eddy current and field inhomogeneity distortions while preserving diffusion tensor information. Diffusion-weighted images (DWIs) are susceptible to disto ... Full text Link to item Cite

HIV, cancer, and coping: The cumulative burden of a cancer diagnosis among people living with HIV.

Journal article J Psychosoc Oncol · 2021 OBJECTIVES: People living with HIV (PLWH) have increased risk for cancer and worse cancer-specific survival. We explored the emotional burden of cancer and HIV as a potential driver of cancer mortality. RESEARCH APPROACH: Semi-structured qualitative interv ... Full text Link to item Cite

Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study.

Journal article Adv Radiat Oncol · 2021 PURPOSE: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases. METHODS AND MATERIALS: Adult patients with 4 to 10 brain metastases ... Full text Link to item Cite

Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators.

Journal article Clin Cancer Res · July 1, 2020 A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatment-related late effects in these pati ... Full text Link to item Cite

Incidence of Opioid-Associated Deaths in Cancer Survivors in the United States, 2006-2016: A Population Study of the Opioid Epidemic.

Journal article JAMA Oncol · July 1, 2020 This study analyzes the incidence of opioid-associated deaths in cancer survivors vs the general population in the US from 2006 through 2016 using National Center for Health Statistics death certificate data. ... Full text Link to item Cite

Evaluating for disparities in place of death for head and neck cancer patients in the United States utilizing the CDC WONDER database.

Journal article Oral Oncol · March 2020 OBJECTIVE: Evaluate trends in place of death for patients with head and neck cancers (HNC) in the U.S. from 1999 to 2017 based on the CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) database. MATERIALS/METHODS: Using patient-level data fro ... Full text Link to item Cite

The impact of the Patient Protection and Affordable Care Act on insurance coverage and cancer-directed treatment in HIV-infected patients with cancer in the United States.

Journal article Cancer · February 1, 2020 BACKGROUND: To the authors' knowledge, little is known regarding the impact of the Patient Protection and Affordable Care Act (ACA) on people living with HIV and cancer (PLWHC), who have lower cancer treatment rates and worse cancer outcomes. To investigat ... Full text Link to item Cite

Off-study utilization of experimental therapies: Analysis of GOG249-eligible cohorts using real world data.

Journal article Gynecol Oncol · January 2020 OBJECTIVE: Adjuvant management of women with high-intermediate- and high-risk early-stage endometrial cancer remains controversial. Recently published results of GOG 249 revealed that vaginal brachytherapy plus chemotherapy (VBT + CT) was not superior to w ... Full text Link to item Cite

Association of human papilloma virus status and response to radiotherapy in vulvar squamous cell carcinoma.

Journal article Int J Gynecol Cancer · January 2020 INTRODUCTION: Vulvar squamous cell carcinoma develops through two separate pathways, associated with the presence or absence of high-risk human papilloma virus (HPV). The objective of this study was to evaluate treatment response and clinical outcomes in w ... Full text Link to item Cite

COVID-19 impact on timing of brachytherapy treatment and strategies for risk mitigation.

Journal article Brachytherapy · 2020 PURPOSE: The purpose of this study was to highlight the importance of timely brachytherapy treatment for patients with gynecologic, breast, and prostate malignancies, and provide a framework for brachytherapy clinical practice and management in response to ... Full text Link to item Cite

Radiation Therapy for Cervical Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal article Pract Radiat Oncol · 2020 PURPOSE: This guideline reviews the evidence and provides recommendations for the indications and appropriate techniques of radiation therapy (RT) in the treatment of nonmetastatic cervical cancer. METHODS: The American Society for Radiation Oncology conve ... Full text Link to item Cite

Multimaterial three-dimensional printing in brachytherapy: Prototyping teaching tools for interstitial and intracavitary procedures in cervical cancers.

Journal article Brachytherapy · 2020 PURPOSE: As the utilization of brachytherapy procedures continues to decline in clinics, a need for accessible training tools is required to help bridge the gap between resident comfort in brachytherapy training and clinical practice. To improve the qualit ... Full text Link to item Cite

Improving Access to Cancer Care in the HIV Population: Qualitative Research to Identify Barriers to Care.

Journal article Health Equity · 2020 Purpose: People living with HIV are less likely to receive cancer treatment and have worse cancer-specific survival, yet underlying drivers of this disparity have minimally been explored. We investigated cancer care barriers from the perspective of patient ... Full text Link to item Cite

Changes on Midchemoradiation Therapy Fluorodeoxyglucose Positron Emission Tomography for Cervical Cancer Are Associated with Prognosis.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2019 PURPOSE: To assess whether radiographic and metabolic changes on midchemoradiation therapy (CRT) fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) for cervical cancer predict outcome. METHODS AND MATERIALS: Women with Int ... Full text Link to item Cite

Place of death by region and urbanization among gynecologic cancer patients: 2006-2016.

Journal article Gynecol Oncol · October 2019 OBJECTIVE: To evaluate associations between US region of residence and urbanization and the place of death among women with gynecologic malignancies in the United States. METHODS: A retrospective cross-sectional study was performed using publicly available ... Full text Link to item Cite

Scores and Misses With New Technology-Walking the Narrow Path of Evidence.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2019 Full text Link to item Cite

Phase 2 Study of Dose-Reduced Consolidation Radiation Therapy in Diffuse Large B-Cell Lymphoma.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2019 PURPOSE: To evaluate the feasibility of reducing the dose of consolidation radiation therapy (RT) in diffuse large B-cell lymphoma. METHODS AND MATERIALS: This phase 2 study enrolled patients with diffuse large B-cell lymphoma, not otherwise specified and ... Full text Link to item Cite

Gender variation in Medicare utilization and payments in gynecologic oncology.

Journal article Gynecol Oncol · September 2019 OBJECTIVES: The Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File (POSPUF) and Medicare Physician and Other Supplier National Provider Identifier (POS NPI) Aggregate Report are publicly available files from the Ce ... Full text Link to item Cite

Radiation Records in the National Cancer Database: Variations in Coding and/or Practice Can Significantly Alter Survival Results.

Journal article JCO Clin Cancer Inform · May 2019 PURPOSE: The aim of the current work was to quantify internally inconsistent and anomalous radiation therapy (RT) data in the National Cancer Database (NCDB) and determine their association with overall survival (OS) using node-positive uterine cancer as a ... Full text Link to item Cite

Disparities in place of death for patients with hematological malignancies, 1999 to 2015.

Journal article Blood Adv · February 12, 2019 Patients with hematologic malignancies (HMs) often receive aggressive end-of-life care and less frequently use hospice. Comprehensive longitudinal reporting on place of death, a key quality indicator, is lacking. Deidentified death certificate data were ob ... Full text Link to item Cite

Changes in insurance coverage for cancer patients receiving brachytherapy before and after enactment of the Affordable Care Act.

Journal article Brachytherapy · 2019 PURPOSE: The Patient Protection and Affordable Care Act called for expansion of Medicaid in 2014. As some states elected to expand Medicaid and others did not, the goal of this study was to determine the effect of Medicaid expansion on the insurance status ... Full text Link to item Cite

HIV, Cancer, and Coping: The Cumulative Burden of a Cancer Diagnosis Among People Living with HIV

Journal article · 2019 Background: People living with HIV (PLWH) have an increased risk for cancer diagnosis and worse cancer-specific survival for several common cancer types. The drivers of mortality among PLWH and cancer are complex and include provider-, patient-, an ... Full text Cite

Place of death for patients with cancer in the United States, 1999 through 2015: Racial, age, and geographic disparities.

Journal article Cancer · November 15, 2018 BACKGROUND: Place of death is an essential component of high quality cancer care and comprehensive national trends and disparities in place of death are unknown. METHODS: Deidentified death certificate data were obtained via the National Center for Health ... Full text Link to item Cite

Stereotactic body radiation therapy versus sublobar resection for stage I NSCLC.

Journal article Lung Cancer · November 2018 PURPOSE: To compare sublobar resection and stereotactic body radiation therapy (SBRT) in patients with stage I non-small cell lung cancer (NSCLC). METHODS: Patients undergoing sublobar resection or SBRT for stage I NSCLC from 2007 to 2014 at Duke Universit ... Full text Link to item Cite

WITHDRAWN: Image Guided HDR Brachytherapy for Pelvic Sidewall Recurrence of Endometrial Cancer.

Journal article Pract Radiat Oncol · October 8, 2018 This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policie ... Full text Link to item Cite

Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma.

Journal article Anticancer Res · May 2018 BACKGROUND/AIM: Optimizing treatment of early-stage Hodgkin lymphoma (HL) requires balancing cure with potential acute and late toxicities from treatment. We reviewed our institutional experience with chemotherapy alone (ChT) versus combined modality thera ... Full text Link to item Cite

Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging.

Journal article Clin Lymphoma Myeloma Leuk · February 2018 INTRODUCTION: The purpose of this study was to evaluate the role of consolidation radiation therapy (RT) in advanced Hodgkin lymphoma (HL) in the setting of a complete metabolic response (CR) to chemotherapy (ChT). PATIENTS AND METHODS: Patients with stage ... Full text Link to item Cite

Cost-Effectiveness of Primary Radiation Therapy Versus Radical Prostatectomy for Intermediate- to High-Risk Prostate Cancer.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2018 PURPOSE: To compare, using a cost-effectiveness analysis, the quality-adjusted life expectancy (QALE) and cost between the 2 treatment options for intermediate- to high-risk prostate cancer: (1) radiation (RT) with androgen deprivation therapy (ADT) or (2) ... Full text Link to item Cite

Trends in Insurance Status Among Patients Diagnosed With Cancer Before and After Implementation of the Affordable Care Act.

Journal article J Oncol Pract · February 2018 PURPOSE: The Affordable Care Act (ACA) aimed to increase insurance coverage through key provisions such as expansion of Medicaid eligibility and enforcement of an individual mandate. The objective of this study is to examine the impact of the ACA on insura ... Full text Link to item Cite

Chemo-radiation, Then on to Surgery.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2018 Full text Link to item Cite

Geriatric Assessment: Precision Medicine for Older Adults With Cancer

Journal article Journal of Oncology Practice · February 2018 Full text Cite

High-volume providers and brachytherapy practice: A Medicare provider utilization and payment analysis.

Journal article Brachytherapy · 2018 PURPOSE: Brachytherapy is an important component of the treatment of gynecologic and prostate cancers, with data supporting its impact on clinical outcomes. Prior data have suggested that brachytherapy tends to be focused at high-volume centers. Medicare r ... Full text Link to item Cite

Real-time dose-rate monitoring with gynecologic brachytherapy: Results of an initial clinical trial.

Journal article Brachytherapy · 2018 PURPOSE: A nanoscintillator-based fiber-optic dosimeter (nanoFOD) was developed to measure real-time dose rate during high-dose-rate (HDR) brachytherapy. A trial was designed to prospectively test clinical feasibility in gynecologic implants. METHODS AND M ... Full text Link to item Cite

Data-Derived Treatment Duration Goal for Cervical Cancer: Should 8 Weeks Remain the Target in the Era of Concurrent Chemoradiation?

Journal article JCO Clin Cancer Inform · November 2017 PURPOSE: Prior studies have demonstrated the importance of treatment duration (TD) in radiation therapy (RT) for cervical cancer, with an 8-week goal based primarily on RT alone. This study uses a contemporary cohort to estimate the time point by which com ... Full text Link to item Cite

Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer.

Journal article Ann Surg Oncol · October 2017 BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with ... Full text Link to item Cite

Insurance coverage among women diagnosed with a gynecologic malignancy before and after implementation of the Affordable Care Act.

Journal article Gynecol Oncol · September 2017 OBJECTIVE: The Patient Protection and Affordable Care Act (ACA) included provisions to expand insurance coverage by expanding Medicaid eligibility, providing subsidies of private coverage and enforcing an individual mandate. The objective of this study is ... Full text Link to item Cite

Patterns of Failure After Surgery for Non-Small-cell Lung Cancer Invading the Chest Wall.

Journal article Clin Lung Cancer · July 2017 INTRODUCTION: The patterns of failure after resection of non-small-cell lung cancer (NSCLC) invading the chest wall are not well documented, and the role of adjuvant radiation therapy (RT) is unclear, prompting the present analysis. MATERIALS AND METHODS: ... Full text Link to item Cite

Mortality reduction and cost-effectiveness of performing hysterectomy at the time of risk-reducing salpingo-oophorectomy for prophylaxis against serous/serous-like uterine cancers in BRCA1 mutation carriers.

Journal article Gynecol Oncol · June 2017 OBJECTIVE: To estimate the survival benefit and cost-effectiveness of performing hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) for BRCA1 mutation carriers. METHODS: Based on a recent prospective cohort study indicating an elevated incidenc ... Full text Link to item Cite

Primary Versus Preoperative Radiation for Locally Advanced Vulvar Cancer.

Journal article Int J Gynecol Cancer · May 2017 OBJECTIVES: The objective of this study was to evaluate patterns of care and the survival impact of primary radiation and preoperative radiation therapy with surgery in women with locally advanced vulvar cancer using a large national cohort. METHODS AND MA ... Full text Link to item Cite

Impact of Chemotherapy and Radiotherapy on Management of Early Stage Clear Cell and Papillary Serous Carcinoma of the Uterus.

Journal article Int J Gynecol Cancer · May 2017 OBJECTIVE: The aim of the study was to assess interaction of lymph node dissection (LND), adjuvant chemotherapy (CT), and radiotherapy (RT) in stage I uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCC). METHODS/MATERIALS: The ... Full text Link to item Cite

The Unique Issues With Brachytherapy in Low- and Middle-Income Countries.

Journal article Semin Radiat Oncol · April 2017 Gynecologic carcinomas, including cervical cancer, present a significant burden on low- and middle-income countries (LMICs). Brachytherapy plays an integral role in the treatment of gynecologic carcinomas, as it is essential for both curative and palliativ ... Full text Link to item Cite

Disparities in the surgical staging of high-grade endometrial cancer in the United States.

Journal article Gynecol Oncol Res Pract · 2017 BACKGROUND: The National Comprehensive Cancer Network (NCCN) and the Society of Gynecologic Oncology (SGO) recommend lymph node sampling (LNS) as a key component in the surgical staging of high-grade endometrial cancer. Our goal was to examine surgical sta ... Full text Open Access Link to item Cite

Is age a prognostic biomarker for survival among women with locally advanced cervical cancer treated with chemoradiation? An NRG Oncology/Gynecologic Oncology Group ancillary data analysis.

Journal article Gynecol Oncol · November 2016 OBJECTIVE: To determine the effect of age on completion of and toxicities following treatment of local regionally advanced cervical cancer (LACC) on Gynecologic Oncology Group (GOG) Phase I-III trials. METHODS: An ancillary data analysis of GOG protocols 1 ... Full text Link to item Cite

Definitive Chemoradiotherapy for Vulvar Cancer.

Journal article Int J Gynecol Cancer · November 2016 OBJECTIVES: This study aimed to evaluate clinical outcomes after chemoradiation (CRT) for the definitive (nonsurgical) treatment of vulvar cancer. MATERIALS AND METHODS: Women with vulvar cancer treated with definitive CRT at a single academic institution ... Full text Link to item Cite

Levonorgestrel Intrauterine Device as an Endometrial Cancer Prevention Strategy in Obese Women: A Cost-Effectiveness Analysis.

Journal article Obstet Gynecol · October 2016 OBJECTIVE: To estimate the cost-effectiveness of the levonorgestrel intrauterine device (IUD) as an endometrial cancer prevention strategy in obese women. METHODS: A modified Markov model was used to compare IUD placement at age 50 with usual care among wo ... Full text Link to item Cite

Vaginal Toxicity From Vaginal Brachytherapy and Capri-Based Systems.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Link to item Cite

Real Time Dosimetry for Gynecologic Brachytherapy: Initial Results of a Prospective Clinical Trial (vol 93, pg S203, 2015)

Journal article INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · June 1, 2016 Link to item Cite

WE-DE-201-07: Measurement of Real-Time Dose for Tandem and Ovoid Brachytherapy Procedures Using a High Precision Optical Fiber Radiation Detector.

Journal article Med Phys · June 2016 PURPOSE: Development of a novel on-line dosimetry tool is needed to move toward patient-specific quality assurance measurements for Ir-192 HDR brachytherapy to verify accurate dose delivery to the intended location. This work describes the development and ... Full text Link to item Cite

Vaginal Dose Is Associated With Toxicity in Image Guided Tandem Ring or Ovoid-Based Brachytherapy.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2016 PURPOSE: To calculate vaginal doses during image guided brachytherapy with volume-based metrics and correlate with long-term vaginal toxicity. METHODS AND MATERIALS: In this institutional review board-approved study, institutional databases were searched t ... Full text Link to item Cite

Adaptive planning using positron emission tomography for locally advanced lung cancer: A feasibility study.

Journal article Pract Radiat Oncol · 2016 PURPOSE: To evaluate the feasibility of adaptive planning using positron emission tomography-computed tomography (PET-CT) in locally advanced non-small cell lung cancer. METHODS AND MATERIALS: Patients with locally advanced non-small cell lung cancer recei ... Full text Link to item Cite

Bariatric surgery as a means to decrease mortality in women with type I endometrial cancer - An intriguing option in a population at risk for dying of complications of metabolic syndrome.

Journal article Gynecol Oncol · September 2015 OBJECTIVE: To estimate the cost-effectiveness and utility of a strategy of offering weight loss surgery (WLS) to women with low risk stage I endometrial cancer (EC) and BMI≥40kg/m(2). METHODS: A modified Markov state transition model was designed to compar ... Full text Link to item Cite

SU-E-J-262: Variability in Texture Analysis of Gynecological Tumors in the Context of An 18F-FDG PET Adaptive Protocol.

Journal article Med Phys · June 2015 PURPOSE: This study examines the effect on texture analysis due to variable reconstruction of PET images in the context of an adaptive FDG PET protocol for node positive gynecologic cancer patients. By measuring variability in texture features from baselin ... Full text Link to item Cite

SU-E-J-249: Characterization of Gynecological Tumor Heterogeneity Using Texture Analysis in the Context of An 18F-FDG PET Adaptive Protocol.

Journal article Med Phys · June 2015 PURPOSE: We propose a method to examine gynecological tumor heterogeneity using texture analysis in the context of an adaptive PET protocol in order to establish if texture metrics from baseline PET-CT predict tumor response better than SUV metrics alone a ... Full text Link to item Cite

SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy.

Journal article Med Phys · June 2015 PURPOSE: In brachytherapy, structures surrounding the target have the potential to move between treatments and receive unknown dose. Deformable image registration could overcome challenges through dose accumulation. This study uses two possible deformable ... Full text Link to item Cite

Gemcitabine-induced radiation recall myositis.

Journal article Skeletal Radiol · March 2015 Radiation recall is an uncommon phenomenon in which administration of a chemotherapeutic agent induces an acute inflammatory reaction in previously irradiated tissues, often weeks to years after completion of radiotherapy. This entity is well known to medi ... Full text Link to item Cite

Smoking history predicts for increased risk of second primary lung cancer: a comprehensive analysis.

Journal article Cancer · February 15, 2015 BACKGROUND: Tobacco use is the most important risk factor for the development of lung cancer. The objective of the current study was to determine the effect of smoking on the development of second primary lung cancers (SPLCs) and other clinical outcomes af ... Full text Link to item Cite

Methods, safety, and early clinical outcomes of dose escalation using simultaneous integrated and sequential boosts in patients with locally advanced gynecologic malignancies.

Journal article Gynecol Oncol · November 2014 OBJECTIVE: To evaluate the safety of dose escalated radiotherapy using a simultaneous integrated boost technique in patients with locally advanced gynecological malignancies. METHODS: Thirty-nine women with locally advanced gynecological malignancies were ... Full text Link to item Cite

A critical ACR Appropriateness Criteria omission Response

Journal article BRACHYTHERAPY · September 1, 2014 Link to item Cite

An investigation of a PRESAGE® in vivo dosimeter for brachytherapy.

Journal article Phys Med Biol · July 21, 2014 Determining accurate in vivo dosimetry in brachytherapy treatment with high dose gradients is challenging. Here we introduce, investigate, and characterize a novel in vivo dosimeter and readout technique with the potential to address this problem. A cylind ... Full text Link to item Cite

SU-E-J-124: FDG PET Metrics Analysis in the Context of An Adaptive PET Protocol for Node Positive Gynecologic Cancer Patients.

Journal article Med Phys · June 2014 PURPOSE: To compare PET extracted metrics and investigate the role of a gradient-based PET segmentation tool, PET Edge (MIM Software Inc., Cleveland, OH), in the context of an adaptive PET protocol for node positive gynecologic cancer patients. METHODS: An ... Full text Link to item Cite

The anatomy of radiation oncology residency training.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2014 Full text Link to item Cite

Body mass index, dose to organs at risk during vaginal brachytherapy, and the role of three-dimensional CT-based treatment planning.

Journal article Brachytherapy · 2014 PURPOSE: To assess the effect of body mass index (BMI) on dose to organs at risk (OARs) during high-dose-rate vaginal brachytherapy and evaluate the role of three-dimensional dose evaluation during treatment planning. METHODS AND MATERIALS: Three-dimension ... Full text Link to item Cite

Response to Dr Sabater.

Journal article Brachytherapy · 2014 Full text Link to item Cite

How much is another randomized trial of lymph node dissection in endometrial cancer worth? A value of information analysis.

Journal article Gynecol Oncol · October 2013 OBJECTIVE: This study aimed to assess the value of a randomized controlled trial (RCT) of lymph node dissection (LND) at the time of hysterectomy for high-risk subsets of women with endometrial cancer. METHODS: A modified Markov decision model compared rou ... Full text Link to item Cite

Local recurrence after surgery for non-small cell lung cancer: a recursive partitioning analysis of multi-institutional data.

Journal article J Thorac Cardiovasc Surg · October 2013 OBJECTIVE: To define subgroups at high risk of local recurrence (LR) after surgery for non-small cell lung cancer using a recursive partitioning analysis (RPA). METHODS: This Institutional Review Board-approved study included patients who underwent upfront ... Full text Link to item Cite

Are discordant positron emission tomography and pathological assessments of the mediastinum in non-small cell lung cancer significant?

Journal article J Thorac Cardiovasc Surg · October 2013 OBJECTIVE: Many patients with non-small cell lung cancer have positive mediastinal lymph nodes on preoperative positron emission tomography (PET) but do not have mediastinal involvement after surgery. The prognostic significance of this discordance was ass ... Full text Link to item Cite

Positron emission tomography in radiation treatment planning: the potential of metabolic imaging.

Journal article Radiol Clin North Am · September 2013 Treatment planning and delivery of radiation therapy has benefited from new technology and techniques. Given the convergence of the improved ability to image active tumor and the delivery of radiation to very specific targets, the implications for a tighte ... Full text Link to item Cite

Image-guided brachytherapy for gynecologic surgeons.

Journal article Surg Oncol Clin N Am · July 2013 Brachytherapy is a fundamental component of the definitive treatment of many advanced gynecologic malignancies, most notably cancers of the uterine corpus and cervix, and allows high radiation doses to be delivered to the target while minimizing the normal ... Full text Link to item Cite

SU-D-108-03: Evaluation of the Feasibility of a Novel Radiochromic Dosimetry System for In-Vivo Dose Verification in Organs at Risk in HDR Intracavitary Gynecological Brachytherapy.

Journal article Med Phys · June 2013 PURPOSE: To evaluate the feasibility of a novel radiochromic dosimetry system for in-vivo dose verification in organs at risk in HDR intracavitary gynecological brachytherapy. METHODS: Novel, small cylindrical PRESAGE dosimeters (4mm in diameter by 20mm in ... Full text Link to item Cite

TH-D-108-01: Implementing MR-Guided Adaptive Brachytherapy for Cervical Cancer.

Journal article Med Phys · June 2013 Image-guidance plays an important role in modern radiation therapy, predominantly in external beam planning and delivery. In recent years, with the advent of high/pulsed dose rate afterloading technology, advanced treatment planning systems, and CT and MRI ... Full text Link to item Cite

Surgical treatment of brachial plexus posterior cord lesion: a combination of nerve and tendon transfers, about nine patients.

Journal article Chir Main · June 2013 Lesions of the posterior cord of the brachial plexus are rare. The symptoms are usually described as palsy of the deltoid and triceps brachii muscles and of the extensor muscles of the wrist, thumb and fingers. If there is no recovery, our strategy is to o ... Full text Link to item Cite

Diabetes mellitus: A significant co-morbidity in the setting of lung cancer?

Journal article Thorac Cancer · May 2013 BACKGROUND: To evaluate the effect of diabetes mellitus (DM) on clinical outcomes in patients managed surgically for non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgery for pathological I-IIIA NSCLC at Duke University from 1995-2005 ... Full text Link to item Cite

Preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal article Radiat Oncol · January 4, 2013 BACKGROUND: To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or gastric adenocarcinoma who underwent neoadjuv ... Full text Link to item Cite

SU‐E‐J‐88: Dose Summation Between Multimodality Treatments for Cervical Cancer

Journal article Medical Physics · January 1, 2013 Purpose: 1) To explore the feasibility of volumetric dose summation between external beam radiation (EBRT) and high dose rate (HDR) brachytherapy treatments for cervical cancer, and 2) to investigate the differences between two deformable registration plat ... Full text Cite

Cost effectiveness of concurrent gemcitabine and cisplatin with radiation followed by adjuvant gemcitabine and cisplatin in patients with stages IIB to IVA carcinoma of the cervix.

Journal article Gynecol Oncol · November 2012 OBJECTIVE: A recent phase III trial reported gemcitabine with cisplatin chemoradiation followed by 2 cycles of gemcitabine and cisplatin (G) significantly improved progression-free (PFS) and overall survival (OS) compared to standard cisplatin chemoradiati ... Full text Link to item Cite

Surgical staging for endometrial cancer in the elderly - Is there a role for lymphadenectomy?

Journal article Obstetrical and Gynecological Survey · November 1, 2012 Full text Cite

Commissioning a CT-compatible LDR tandem and ovoid applicator using Monte Carlo calculation and 3D dosimetry.

Journal article Med Phys · July 2012 PURPOSE: To determine the geometric and dose attenuation characteristics of a new commercially available CT-compatible LDR tandem and ovoid (T&O) applicator using Monte Carlo calculation and 3D dosimetry. METHODS: For geometric characterization, we quantif ... Full text Link to item Cite

Surgical staging for endometrial cancer in the elderly - is there a role for lymphadenectomy?

Journal article Gynecol Oncol · July 2012 OBJECTIVES: We sought to evaluate the effect of systematic lymphadenectomy (LND) on endometrial cancer-specific survival in an elderly population. METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) program from 1988 to ... Full text Link to item Cite

Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy.

Journal article J Thorac Oncol · July 2012 BACKGROUND: Lymphovascular space invasion (LVI) is an established negative prognostic factor and an indication for postoperative radiation therapy in many malignancies. The purpose of this study was to evaluate LVI in patients with early-stage non-small-ce ... Full text Link to item Cite

SU-D-213AB-05: Commissioning a CT Compatible LDR T&O Applicator Using Analytical Calculation with ID and 3D Dosimetry.

Journal article Med Phys · June 2012 PURPOSE: To determine the characteristics of a new commercially available CT-compatible LDR Tandem and Ovoid (T&O) applicator using 3D dosimetry. METHODS: We characterized source attenuation through the asymmetric gold shielding in the buckets by measuring ... Full text Link to item Cite

Local failure in resected N1 lung cancer: implications for adjuvant therapy.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2012 PURPOSE: To evaluate actuarial rates of local failure in patients with pathologic N1 non-small-cell lung cancer and to identify clinical and pathologic factors associated with an increased risk of local failure after resection. METHODS AND MATERIALS: All p ... Full text Link to item Cite

The influence of radiation modality and lymph node dissection on survival in early-stage endometrial cancer.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 BACKGROUND: The appropriate uses of lymph node dissection (LND) and adjuvant radiation therapy (RT) for Stage I endometrial cancer are controversial. We explored the impact of specific RT modalities (whole pelvic RT [WPRT], vaginal brachytherapy [VB]) and ... Full text Link to item Cite

Adjuvant radiotherapy in the treatment of invasive intraductal papillary mucinous neoplasm of the pancreas: an analysis of the surveillance, epidemiology, and end results registry.

Journal article Ann Surg Oncol · April 2012 BACKGROUND: Management and outcomes of patients with invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas are not well established. We investigated whether adjuvant radiotherapy (RT) improved cancer-specific survival (CSS) and overall su ... Full text Open Access Link to item Cite

Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2012 PURPOSE: To evaluate the prognostic significance of different descriptive parameters in head-and-neck cancer patients undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography (FDG-PET) imaging. PATIENTS AND METHODS: Head-and-neck cancer ... Full text Link to item Cite

Primary radiation therapy for medically inoperable patients with clinical stage I and II endometrial carcinoma.

Journal article Gynecol Oncol · January 2012 OBJECTIVE: To determine the outcomes associated with primary radiation therapy for medically inoperable, clinical stage I and II, endometrial adenocarcinoma (EAC). METHODS: A multi-institution, retrospective chart review from January 1997 to January 2009 w ... Full text Link to item Cite

Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors.

Journal article Int J Radiat Oncol Biol Phys · November 1, 2011 PURPOSE: To assess factors associated with severe pulmonary toxicity after myeloablative conditioning using total body irradiation (TBI) followed by allogeneic stem cell transplantation. METHODS AND MATERIALS: A total of 101 adult patients who underwent TB ... Full text Link to item Cite

Persistent N2 disease after neoadjuvant chemotherapy for non-small-cell lung cancer.

Journal article J Thorac Cardiovasc Surg · November 2011 OBJECTIVES: Patients achieving a mediastinal pathologic complete response with neoadjuvant chemotherapy have improved outcomes compared with patients with persistent N2 disease. How to best manage this latter group of patients is unknown, prompting a revie ... Full text Link to item Cite

Radiotherapy in the treatment of patients with unresectable extrahepatic cholangiocarcinoma.

Journal article Int J Radiat Oncol Biol Phys · November 1, 2011 PURPOSE: Extrahepatic cholangiocarcinoma is an uncommon but lethal malignancy. We analyzed the role of definitive chemoradiotherapy for patients with nonmetastatic, locally advanced extrahepatic cholangiocarcinoma treated at a single institution. METHODS A ... Full text Link to item Cite

What Are The Causes Of Death For Women With Early-stage Endometrial Cancer?

Journal article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Lymphovascular Invasion in Non-small Cell Lung Cancer: Implications for Staging and Adjuvant Therapy

Journal article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Pathologic N1 Non-small Cell Lung Cancer: Identifying Subsets of Patients at High Risk of Local Failure

Journal article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Incorporating gross anatomy education into radiation oncology residency: a 2-year curriculum with evaluation of resident satisfaction.

Journal article J Am Coll Radiol · May 2011 PURPOSE: Radiation oncologists require a thorough understanding of anatomy, but gross anatomy is not part of the standard residency curriculum. "Oncoanatomy" is an educational program for radiation oncology residents at Duke University that integrates cada ... Full text Link to item Cite

How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems.

Journal article J Thorac Oncol · April 2011 INTRODUCTION: To evaluate how well the tumor, node, metastasis (TNM) 6 and TNM 7 staging systems predict rates of local/regional recurrence (LRR) after surgery alone for non-small cell lung cancer. METHODS: All patients who underwent surgery for non-small ... Full text Link to item Cite

Teaching the anatomy of oncology: evaluating the impact of a dedicated oncoanatomy course.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2011 Featured Work PURPOSE: Anatomic considerations are often critical in multidisciplinary cancer care. We developed an anatomy-focused educational program for radiation oncology residents integrating cadaver dissection into the didactic review of diagnostic, surgical, radi ... Full text Link to item Cite

Single-institution experience of preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal article Journal of Clinical Oncology · February 1, 2011 99 Background: To examine acute toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. Methods: Patients with gastroesophageal (GE) junction (Siewert type II and ... Full text Cite

Single-institution experience of preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal article J Clin Oncol · February 2011 99 Background: To examine acute toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or stomach adenocarcinoma who underwent ... Link to item Cite

The impact of radiation therapy in patients with diffuse large B-cell lymphoma with positive post-chemotherapy FDG-PET or gallium-67 scans.

Journal article Ann Oncol · February 2011 Featured Work BACKGROUND: 2-[fluorine-18]fluoro-2-deoxy-D-glucose-positron emission tomography (PET) and gallium-67 citrate (gallium) response after chemotherapy are powerful prognostic factors in diffuse large B-cell lymphoma (DLBCL). However, clinical outcomes when co ... Full text Link to item Cite

Development of an ovarian cancer screening decision model that incorporates disease heterogeneity: implications for potential mortality reduction.

Journal article Cancer · February 1, 2011 BACKGROUND: Pathologic and genetic data suggest that epithelial ovarian cancer may consist of indolent and aggressive phenotypes. The objective of the current study was to estimate the impact of a 2-phenotype paradigm of epithelial ovarian cancer on the mo ... Full text Link to item Cite

Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer.

Journal article Cancer · November 1, 2010 Featured Work BACKGROUND: The risk of developing brain metastases after definitive treatment of locally advanced nonsmall cell lung cancer (NSCLC) is approximately 30%-50%. The risk for patients with early stage disease is less defined. The authors sought to investigate ... Full text Link to item Cite

Biologically effective dose (BED) correlation with biochemical control after low-dose rate prostate brachytherapy for clinically low-risk prostate cancer.

Journal article Int J Radiat Oncol Biol Phys · May 1, 2010 Featured Work PURPOSE: To assess the correlation of postimplant dosimetric quantifiers with biochemical control of prostate cancer after low-dose rate brachytherapy. METHODS AND MATERIALS: The biologically effective dose (BED), dose in Gray (Gy) to 90% of prostate (D(90 ... Full text Link to item Cite

Preoperative chemotherapy versus preoperative chemoradiotherapy for stage III (N2) non-small-cell lung cancer.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2009 Featured Work PURPOSE: To compare preoperative chemotherapy (ChT) and preoperative chemoradiotherapy (ChT-RT) in operable Stage III non-small-cell lung cancer. METHODS AND MATERIALS: This retrospective study analyzed all patients with pathologically confirmed Stage III ... Full text Link to item Cite

Robot-assisted laparoscopic prostatectomy is not associated with early postoperative radiation therapy.

Journal article BJU Int · November 2009 Featured Work OBJECTIVE: To compare open radical prostatectomy (RP) and robot-assisted laparoscopic prostatectomy (RALP), and to determine whether RALP is associated with a higher risk of features that determine recommendations for postoperative radiation therapy (RT). ... Full text Link to item Cite

Paraganglioma of the head and neck: long-term local control with radiotherapy.

Journal article Am J Clin Oncol · June 2009 Featured Work OBJECTIVES: Paragangliomas are rare neuroendocrine neoplasms of the head and neck. Treatment strategies include resection, definitive external beam radiation therapy (EBRT), stereotactic radiosurgery (SRS), or observation alone. Due to their rarity and ind ... Full text Link to item Cite

Morbidity and prostate-specific antigen control of external beam radiation therapy plus low-dose-rate brachytherapy boost for low, intermediate, and high-risk prostate cancer.

Journal article Brachytherapy · 2009 Featured Work PURPOSE: Dose escalation has been shown beneficial in prostate cancer. Brachytherapy (BT) provides an opportunity for dose escalation beyond what can be safely delivered using only teletherapy methods. The purpose of this study was to determine cancer cont ... Full text Link to item Cite

In Reply to Drs. Lymberis and Formenti

Journal article International Journal of Radiation Oncology Biology Physics · September 1, 2008 Full text Cite

In Reply to Dr. Hama

Journal article International Journal of Radiation Oncology Biology Physics · September 1, 2008 Full text Cite

Prone positioning causes the heart to be displaced anteriorly within the thorax: implications for breast cancer treatment.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2008 Featured Work INTRODUCTION: Prone positioning has been suggested as an alternative to the conventional supine position for patients receiving breast radiotherapy, but few data exist on how this may alter heart location. We herein quantitatively compare the intrathoracic ... Full text Link to item Cite

Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2007 Featured Work PURPOSE: To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT). METHODS AND MATERIALS: ... Full text Link to item Cite

Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer.

Journal article Int J Radiat Oncol Biol Phys · November 1, 2007 Featured Work PURPOSE: To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer. METHODS AND MATER ... Full text Link to item Cite