Justin Savage

Journal article bioRxiv · October 10, 2024 CRISPR/Cas9-based genome engineering enables rapid and precise gene manipulations in the CNS. Here, we developed a non-invasive astrocyte-specific method utilizing a single AAV vector, which we named GEARBOCS (Gene Editing in AstRocytes Based On CRISPR/Cas ... Full text Link to item Cite

SynBot: An open-source image analysis software for automated quantification of synapses.

Journal article bioRxiv · July 12, 2024 The formation of precise numbers of neuronal connections, known as synapses, is crucial for brain function. Therefore, synaptogenesis mechanisms have been one of the main focuses of neuroscience. Immunohistochemistry is a common tool for visualizing synaps ... Full text Link to item Cite

δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.

Journal article J Cell Biol · November 6, 2023 Astrocytes control the formation of specific synaptic circuits via cell adhesion and secreted molecules. Astrocyte synaptogenic functions are dependent on the establishment of their complex morphology. However, it is unknown if distinct neuronal cues diffe ... Full text Link to item Cite

HepaCAM controls astrocyte self-organization and coupling.

Journal article Neuron · August 4, 2021 Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic development and function. This process is regulated by transcellular interactions between astrocytes and neurons via cell adhesion molecules. How astrocytes coordinate ... Full text Link to item Cite

Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.

Journal article Neurosci Bull · August 2021 Programmed cell death protein 1 (PD-1) is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated remarkable efficacy in cancer treatment. Accumulating evidence suggests an important role of P ... Full text Link to item Cite