Scholars@Duke
John Wiley Williams Jr.

John Wiley Williams Jr.

Professor Emeritus of Medicine
Medicine, General Internal Medicine
Duke Box 104427, Durham, NC 27705
ORCID iDhttps://orcid.org/0000-0002-5267-5558
710 W Main Street, 1st Floor, Durham, NC 27701

Scholarly Works

Statistical analyses of ecological multinomial time series to identify environmental drivers and biotic interactions

Journal article Methods in Ecology and Evolution · July 2026 AbstractUnderstanding the drivers of change in communities is a major goal of paleoecology and commu ... Full text Cite

Concepts and Methods for Identifying Species Niche Edges, Potentially Truncated Edges, and Climate Risks and Opportunities

Journal article Global Ecology and Biogeography · April 2026 ABSTRACTAimUnmitigated climate change will subject species to environments unlike any experienced for millions of years, creati ... Full text Cite

Advancing ecology and evolution through continental scientific drilling.

Journal article Trends Ecol Evol · February 2026 The geological record contains a rich history of the coupled evolution of life and the Earth that sustains it. However, that history is often buried deeply and is difficult to access. Scientific drilling can access these buried histories and provides found ... Full text Link to item Cite

Are Ecotonal Systems More Sensitive to Climate Change? Past Ecotonal Dynamics and Rates of Vegetation Change in Michigan

Journal article Global Ecology and Biogeography · December 2025 ABSTRACTAimEcotones are expected to be sensitive to climate change, but supporting evidence is scarce. Here we test the ecotona ... Full text Cite

Holocene land cover change in North America: continental trends, regional drivers, and implications for vegetation–atmosphere feedbacks

Journal article Climate of the Past · November 6, 2025 Abstract. Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation–atmosphere interactions are of particular interest, both to understand the climate effects of intensifying hum ... Full text Cite

Ecological acclimation: A framework to integrate fast and slow responses to climate change

Journal article Functional Ecology · August 2025 AbstractEcological responses to climate change occur across vastly different time‐scales, from minutes for physiological plasticity to decades or centuries for community turnover and ev ... Full text Cite

Abstract A038: Inducing tumor associated tertiary lymphoid structures using cellular therapy

Conference Cancer Immunology Research · February 23, 2025 AbstractTargeting the tumor microenvironment (TME) to be more immune permissive is a potential strategy for enhancing immunotherapies, such as chimeric antigen receptor T cell (CAR-T) therapy, providing a pr ... Full text Cite

Effectiveness of Synchronous Postdischarge Contacts on Health Care Use and Patient Satisfaction : A Systematic Review and Meta-analysis.

Journal article Ann Intern Med · February 2025 BACKGROUND: Postdischarge contacts (PDCs) after hospitalization are common practice, but their effectiveness in reducing use of acute care after discharge remains unclear. PURPOSE: To assess the effects of PDC on 30-day emergency department (ED) visits, 30 ... Full text Open Access Link to item Cite

The Indo–Pacific Pollen Database – a Neotoma constituent database

Journal article Climate of the Past · November 11, 2024 Abstract. The Indo–Pacific Pollen Database (IPPD) is the brainchild of the late professor Geoffrey Hope, who gathered pollen records from across the region to ensure their preservation for future generations of palaeoecologists. This noble aim is n ... Full text Cite

Anticonvulsants in the Treatment of Behavioral and Psychological Symptoms in Dementia: A Systematic Review.

Journal article Am J Geriatr Psychiatry · October 2024 OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are common and impart a significant burden to patients, caregivers, and the health system. However, there are few pharmacological options for treating BPSD. We conducted a systematic revi ... Full text Link to item Cite

Interacting effects of fire and hydroclimate on oak and beech community prevalence in the southern Great Lakes region

Journal article Journal of Ecology · May 2024 AbstractRising temperatures, increasing hydroclimate variability and intensifying disturbance regimes increase the risk of rapid ecosystem conversions. We can leverage multi‐proxy recor ... Full text Cite

A horizon scan for novel and impactful areas of physical geography research in 2023 and beyond

Journal article Progress in Physical Geography: Earth and Environment · February 2024 This editorial reports on a horizon scan exercise that was undertaken to identify new frontier topics, new or emerging themes/concepts, or new philosophical questions of relevance to physical geography. Researchers with broad geographical and disci ... Full text Cite

Strengthening global-change science by integrating aeDNA with paleoecoinformatics.

Journal article Trends Ecol Evol · October 2023 Ancient environmental DNA (aeDNA) data are close to enabling insights into past global-scale biodiversity dynamics at unprecedented taxonomic extent and resolution. However, achieving this potential requires solutions that bridge bioinformatics and paleoec ... Full text Link to item Cite

Videoconferencing of Movement-Based and Psychologically Informed Interventions for Chronic Pain: A Systematic Review and Horizon Scan.

Journal article Telemed J E Health · September 2023 Introduction: With the coronavirus disease 2019 (COVID-19) pandemic, use of telehealth technology increased dramatically. Nonpharmacological approaches to pain management may be well suited for virtual care. Yet, it is not widely understood if this treatme ... Full text Link to item Cite

Frontline Clinician Appraisement of Research Engagement: "I feel out of touch with research".

Journal article J Gen Intern Med · September 2023 BACKGROUND: Health services research can benefit from frontline clinician input across all stages of research, yet their key perspectives are often not meaningfully engaged. OBJECTIVE: How can we improve clinician engagement in research? DESIGN: Convenienc ... Full text Open Access Link to item Cite

Efficacy of Epidural Blood Patching or Surgery in Spontaneous Intracranial Hypotension: A Systematic Review and Evidence Map.

Journal article AJNR Am J Neuroradiol · June 2023 BACKGROUND: Spontaneous intracranial hypotension is an important cause of treatable secondary headaches. Evidence on the efficacy of epidural blood patching and surgery for spontaneous intracranial hypotension has not been synthesized. PURPOSE: Our aim was ... Full text Link to item Cite

Characterization of dominant-negative growth hormone receptor variants reveals a potential therapeutic target for short stature.

Journal article Eur J Endocrinol · April 4, 2023 OBJECTIVE: Growth hormone insensitivity (GHI) encompasses growth restriction, normal/elevated growth hormone (GH), and low insulin-like growth factor I (IGF1). "Nonclassical" GHI is poorly characterized and is rarely caused by heterozygous dominant-negativ ... Full text Link to item Cite

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians.

Journal article Ann Intern Med · February 2023 DESCRIPTION: This guideline updates the 2017 American College of Physicians (ACP) recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults. METHODS: The ACP Clinical Guidelines Committee based these ... Full text Link to item Cite

Barriers and facilitators to the implementation and adoption of improvement coaching: A qualitative evidence synthesis.

Journal article J Clin Nurs · January 2023 BACKGROUND: Healthcare organisations and teams perform improvement activities to facilitate high-quality healthcare. The use of an improvement coach who provides support and guidance to the healthcare team may facilitate improvement activities; however, no ... Full text Link to item Cite

Extensions of Health Economic Evaluations in R for Microsoft Excel Users: A Tutorial for Incorporating Heterogeneity and Conducting Value of Information Analyses.

Journal article Pharmacoeconomics · January 2023 Advanced health economic analysis techniques currently performed in Microsoft Excel, such as incorporating heterogeneity, time-dependent transitions and a value of information analysis, can be easily transferred to R. Often the outputs of survival analyses ... Full text Link to item Cite

Health Economic Evaluation Using Markov Models in R for Microsoft Excel Users: A Tutorial.

Journal article Pharmacoeconomics · January 2023 A health economic evaluation (HEE) is a comparative analysis of alternative courses of action in terms of both costs and consequences. A cost-effectiveness analysis is a type of HEE that compares an intervention to one or more alternatives by estimating ho ... Full text Link to item Cite

Universal testing for hepatitis B and hepatitis C in the emergency department: a cost-effectiveness and budget impact analysis of two urban hospitals in the United Kingdom.

Journal article Cost Eff Resour Alloc · November 14, 2022 BACKGROUND: Numerous studies have shown the effectiveness of testing for hepatitis B (HBV) and hepatitis C (HCV) in emergency departments (ED), due to the elevated prevalence amongst attendees. The aim of this study was to conduct a cost-effectiveness anal ... Full text Link to item Cite

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review.

Journal article J Med Internet Res · August 26, 2022 BACKGROUND: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of t ... Full text Link to item Cite

A retrospective analysis of endocrine disease in sphingosine-1-phosphate lyase insufficiency: case series and literature review.

Journal article Endocr Connect · August 1, 2022 Sphingosine-1-phosphate lyase (SGPL1) insufficiency syndrome (SPLIS) is an autosomal recessive multi-system disorder, which mainly incorporates steroid-resistant nephrotic syndrome and primary adrenal insufficiency. Other variable endocrine manifestations ... Full text Link to item Cite

Economic evaluation of tranexamic acid for the treatment of acute gastrointestinal bleeding: a cost-effectiveness analysis using data from the HALT-IT randomised controlled trial

Journal article BMJ Open · July 2022 Objective To perform an economic evaluation of tranexamic acid (TXA) versus no-TXA, in addition to current clinical practice, for acute gastrointesti ... Full text Cite

VirA+EmiC project: Evaluating real-world effectiveness and sustainability of integrated routine opportunistic hepatitis B and C testing in a large urban emergency department.

Journal article J Viral Hepat · July 2022 Innovative testing approaches and care pathways are required to meet global hepatitis B virus (HBV) and hepatitis C virus (HCV) elimination goals. Routine blood-borne virus (BBV) testing in emergency departments (EDs) in high-prevalence areas is suggested ... Full text Link to item Cite

8000-year doubling of Midwestern forest biomass driven by population- and biome-scale processes

Journal article Science · June 24, 2022 Changes in woody biomass over centuries to millennia are poorly known, leaving unclear the magnitude of terrestrial carbon fluxes before industrial-era disturbance. Here, we statistically reconstructed changes in woody biomass across the upper Midw ... Full text Cite

Efficacy of epidural blood patching or surgery in spontaneous intracranial hypotension: an evidence map protocol.

Journal article Syst Rev · June 7, 2022 BACKGROUND: Spontaneous intracranial hypotension (SIH) is a debilitating disorder caused by non-iatrogenic spinal cerebrospinal fluid leaks. SIH is increasingly recognized as an important treatable cause of secondary headaches. Treatment involves either ep ... Full text Link to item Cite

Field and full-scale laboratory testing of prototype wildland fire shelters

Journal article International Journal of Wildland Fire · May 25, 2022 This paper describes a series of tests conducted to evaluate prototype fire shelters designed to provide enhanced thermal protective insulation in wildland fire burn-over events. Full-scale laboratory and field tests are used to compare the thermal ... Full text Cite

A cost-effectiveness and value of information analysis to inform future research of tranexamic acid for older adults experiencing mild traumatic brain injury.

Journal article Trials · May 3, 2022 BACKGROUND: Tranexamic acid reduces head injury deaths in patients with CT scan evidence of intracranial bleeding after mild traumatic brain injury (TBI). However, the cost-effectiveness of tranexamic acid for people with mild TBI in the pre-hospital setti ... Full text Link to item Cite

Primary Care Engagement Among Individuals with Experiences of Homelessness and Serious Mental Illness: an Evidence Map.

Journal article J Gen Intern Med · May 2022 BACKGROUND: Experiences of homelessness and serious mental illness (SMI) negatively impact health and receipt of healthcare. Interventions that promote the use of primary care services for people with both SMI and homelessness may improve health outcomes, ... Full text Link to item Cite

Effectiveness of Quality Improvement Coaching on Process Outcomes in Health Care Settings: A Systematic Review.

Journal article J Gen Intern Med · March 2022 BACKGROUND: A culture of improvement is an important feature of high-quality health care systems. However, health care teams often need support to translate quality improvement (QI) activities into practice. One method of support is consultation from a QI ... Full text Link to item Cite

Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Journal article Ann Intern Med · March 2022 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the role of colonoscopy for diagnostic evaluation of colorectal cancer (CRC) after a presumed diagnosis of acute left-sided colonic divert ... Full text Link to item Cite

Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Journal article Ann Intern Med · March 2022 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the diagnosis and management of acute left-sided colonic diverticulitis in adults. This guideline is based on current best available evide ... Full text Link to item Cite

Isotopic filtering reveals high sensitivity of planktic calcifiers to Paleocene-Eocene thermal maximum warming and acidification.

Journal article Proc Natl Acad Sci U S A · March 1, 2022 Ocean warming and acidification driven by anthropogenic carbon emissions pose an existential threat to marine calcifying communities. A similar perturbation to global carbon cycling and ocean chemistry occurred ∼56 Ma during the Paleocene-Eocene thermal ma ... Full text Link to item Cite

RAD: A Paradigm, Shifting.

Journal article Bioscience · January 2022 Full text Link to item Cite

A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT.

Journal article Health Technol Assess · October 2021 BACKGROUND: Tranexamic acid reduces blood loss in surgery and the risk of death in trauma patients. Meta-analyses of small trials suggest that tranexamic acid decreases the number of deaths from gastrointestinal bleeding, but these meta-analyses are prone ... Full text Link to item Cite

Adjustment Disorders in U.S. Active Duty Military Women: A Scoping Review for the Years 2000 to 2018.

Journal article Womens Health Issues · August 25, 2021 BACKGROUND: Adjustment disorder (AD) is the most common mental health diagnosis in the U.S. military and is more than twice as likely to be diagnosed in active duty servicewomen as compared with male servicemembers. The literature on ADs, particularly in f ... Full text Link to item Cite

Brain Activity Fluctuations Propagate as Waves Traversing the Cortical Hierarchy.

Journal article Cereb Cortex · July 29, 2021 The brain exhibits highly organized patterns of spontaneous activity as measured by resting-state functional magnetic resonance imaging (fMRI) fluctuations that are being widely used to assess the brain's functional connectivity. Some evidence suggests tha ... Full text Link to item Cite

Growth Hormone Receptor (GHR) 6Ω Pseudoexon Activation: a Novel Cause of Severe Growth Hormone Insensitivity.

Journal article J Clin Endocrinol Metab · July 28, 2021 CONTEXT: Severe forms of growth hormone insensitivity (GHI) are characterized by extreme short stature, dysmorphism, and metabolic anomalies. OBJECTIVE: This work aims to identify the genetic cause of growth failure in 3 "classical" GHI individuals. METHOD ... Full text Link to item Cite

Options for Meaningful Engagement in Clinical Research for Busy Frontline Clinicians.

Journal article J Gen Intern Med · July 2021 In order for health care innovations to be effective and actionable, they must align with the needs and practice patterns of those delivering care at the bedside. While research has started to incorporate the patient voice, it has yet to fully invest in th ... Full text Link to item Cite

Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients for Initial or Postextubation Management of Acute Respiratory Failure: A Clinical Guideline From the American College of Physicians.

Journal article Ann Intern Med · July 2021 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of high-flow nasal oxygen (HFNO) in hospitalized patients for initial or postextubation management of acute respirator ... Full text Link to item Cite

Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings: A Clinical Guideline From the American College of Physicians.

Journal article Ann Intern Med · July 2021 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of point-of-care ultrasonography (POCUS) in patients with acute dyspnea in emergency department (ED) or inpatient sett ... Full text Link to item Cite

EFFECTIVENESS OF QUALITY IMPROVEMENT COACHING: A SYSTEMATIC REVIEW

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · July 2021 Link to item Cite

Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

Journal article J Aerosol Med Pulm Drug Deliv · June 2021 Rationale: There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). Objectives: To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 ... Full text Open Access Link to item Cite

Global acceleration in rates of vegetation change over the past 18,000 years.

Journal article Science · May 21, 2021 Global vegetation over the past 18,000 years has been transformed first by the climate changes that accompanied the last deglaciation and again by increasing human pressures; however, the magnitude and patterns of rates of vegetation change are poorly unde ... Full text Link to item Cite

Eric C. Grimm 1951–2020

Journal article Vegetation History and Archaeobotany · May 2021 Full text Cite

A novel variant of the human dopamine D2 receptor, associated with a hyperkinetic movement disorder, mediates enhanced activation of G proteins

Conference The FASEB Journal · May 2021 A novel DRD2 variant with a mutation in exon 5 of DRD2 (c.634A>T; p.I212F)has been identif ... Full text Cite

Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT.

Journal article Health Technol Assess · April 2021 BACKGROUND: Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death. We assessed the effects of tranexamic acid in traumatic brain in ... Full text Link to item Cite

Forest responses to last-millennium hydroclimate variability are governed by spatial variations in ecosystem sensitivity.

Journal article Ecol Lett · March 2021 Forecasts of future forest change are governed by ecosystem sensitivity to climate change, but ecosystem model projections are under-constrained by data at multidecadal and longer timescales. Here, we quantify ecosystem sensitivity to centennial-scale hydr ... Full text Link to item Cite

Implementing remote triage in large health systems: A qualitative evidence synthesis.

Journal article Res Nurs Health · February 2021 Remote triage (RT) allows interprofessional teams (e.g., nurses and physicians) to assess patients and make clinical decisions remotely. RT use has developed widespread interest due to the COVID-19 pandemic, and has future potential to address the needs of ... Full text Link to item Cite

Caught in a bottleneck: Habitat loss for woolly mammoths in central North America and the ice‐free corridor during the last deglaciation

Journal article Global Ecology and Biogeography · February 2021 AbstractAimIdentifying how climate change, habitat loss, and corridors interact to influence species survival or extinction is critical to understanding macro‐scale biodiversity dynamics u ... Full text Cite

Virtual Care for the Longitudinal Management of Chronic Conditions: A Systematic Review

Conference · 2021 As both the largest integrated health system and largest provider of telehealth in the country, the Veterans Health Administration (VHA) has a particular interest in understanding how best to implement and utilize virtual care. VHA has long embraced virtua ... Cite

The forests of the midwestern United States at Euro-American settlement: Spatial and physical structure based on contemporaneous survey data.

Journal article PLoS One · 2021 We present gridded 8 km-resolution data products of the estimated stem density, basal area, and biomass of tree taxa at Euro-American settlement of the midwestern United States during the middle to late 19th century for the states of Minnesota, Wisconsin, ... Full text Link to item Cite

A unifying framework for studying and managing climate-driven rates of ecological change.

Journal article Nat Ecol Evol · January 2021 During the Anthropocene and other eras of rapidly changing climates, rates of change of ecological systems can be described as fast, slow or abrupt. Fast ecological responses closely track climate change, slow responses substantively lag climate forcing, c ... Full text Link to item Cite

More than one way to kill a spruce forest: The role of fire and climate in the late‐glacial termination of spruce woodlands across the southern Great Lakes

Journal article Journal of Ecology · January 2021 Abstract In the southern Great Lakes Region, North America, between 19,000 ... Full text Cite

Spatial Fingerprint of Younger Dryas Cooling and Warming in Eastern North America

Journal article Geophysical Research Letters · November 28, 2020 AbstractThe Younger Dryas (YD, 12.9–11.7 ka) is the most recent, near‐global interval of abrupt climate change with rates similar to modern global warming. Understanding the causes and biodiversity effects of YD climate cha ... Full text Cite

Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians.

Journal article Ann Intern Med · November 3, 2020 DESCRIPTION: The American College of Physicians (ACP) and American Academy of Family Physicians (AAFP) developed this guideline to provide clinical recommendations on nonpharmacologic and pharmacologic management of acute pain from non-low back, musculoske ... Full text Link to item Cite

Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach.

Journal article BMJ Glob Health · September 2020 INTRODUCTION: An estimated 69 million traumatic brain injuries (TBI) occur each year worldwide, with most in low-income and middle-income countries. The CRASH-3 randomised trial found that intravenous administration of tranexamic acid within 3 hours of inj ... Full text Link to item Cite

Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction.

Journal article J Steroid Biochem Mol Biol · September 2020 Deficiency in Sphingosine-1-phosphate lyase (S1P lyase) is associated with a multi-systemic disorder incorporating primary adrenal insufficiency (PAI), steroid resistant nephrotic syndrome and neurological dysfunction. Accumulation of sphingolipid intermed ... Full text Link to item Cite

An Economic Evaluation of the Cost-Effectiveness of Opt-Out Hepatitis B and Hepatitis C Testing in an Emergency Department Setting in the United Kingdom.

Journal article Value Health · August 2020 OBJECTIVES: The prevalence of hepatitis is high in emergency department (ED) attendees in the United Kingdom, with a prevalence of up to 2% for hepatitis B (HBV) HBsAg, and 2.9% for hepatitis C (HCV) RNA. The aim of this paper is to perform an economic eva ... Full text Link to item Cite

Genetic capitalism and stabilizing selection of antimicrobial resistance genotypes in Escherichia coli.

Journal article Cladistics · August 2020 Antimicrobial resistance (AMR) in pathogenic strains of bacteria, such as Escherichia coli (E. coli), adversely impacts personal and public health. In this study, we examine competing hypotheses for the evolution of AMR including (i) 'genetic capitalism' i ... Full text Link to item Cite

Risk for Nephrogenic Systemic Fibrosis After Exposure to Newer Gadolinium Agents: A Systematic Review.

Journal article Ann Intern Med · July 21, 2020 BACKGROUND: The risk for nephrogenic systemic fibrosis (NSF) after exposure to newer versus older gadolinium-based contrast agents (GBCAs) remains unclear. PURPOSE: To synthesize evidence about NSF risk with newer versus older GBCAs across the spectrum of ... Full text Link to item Cite

Effectiveness of Acute Care Remote Triage Systems: a Systematic Review.

Journal article J Gen Intern Med · July 2020 BACKGROUND: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We ... Full text Open Access Link to item Cite

GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tables.

Journal article J Clin Epidemiol · June 2020 OBJECTIVES: This article provides updated GRADE guidance about how authors of systematic reviews and health technology assessments and guideline developers can rate the certainty of evidence (also known as quality of the evidence or confidence in the estim ... Full text Link to item Cite

GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy.

Journal article J Clin Epidemiol · June 2020 OBJECTIVES: This article provides updated GRADE guidance about how authors of systematic reviews and health technology assessments and guideline developers can assess the results and the certainty of evidence (also known as quality of the evidence or confi ... Full text Link to item Cite

Comparison of settlement-era vegetation reconstructions for STEPPS and REVEALS pollen–vegetation models in the northeastern United States

Journal article Quaternary Research · May 2020 AbstractReconstructions of prehistoric vegetation composition help establish natural baselines, variability, and trajectories of forest dynamics before and during the emergence of intensive anthropogenic land use. Pollen–ve ... Full text Cite

Barriers and facilitators to implementation of epilepsy self-management programs: a systematic review using qualitative evidence synthesis methods.

Journal article Syst Rev · April 25, 2020 BACKGROUND: Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting a self-management program requires ... Full text Open Access Link to item Cite

Climate change, ecosystems and abrupt change: science priorities

Journal article Philosophical Transactions of the Royal Society B: Biological Sciences · March 16, 2020 Ecologists have long studied patterns, directions and tempos of change, but there is a pressing need to extend current understanding to empirical observations of abrupt changes as climate warming accelerates. Abrupt changes in ecological systems (A ... Full text Cite

GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients.

Journal article Endocr Connect · March 2020 OBJECTIVES: The homozygous GH receptor (GHR) pseudoexon (6Ψ) mutation leads to growth hormone insensitivity (GHI) with clinical and biochemical heterogeneity. We investigated whether transcript heterogeneity (6Ψ-GHR to WT-GHR transcript ratio) and/or concu ... Full text Link to item Cite

Cost effectiveness of an intervention to increase uptake of hepatitis C virus testing and treatment (HepCATT): cluster randomised controlled trial in primary care.

Journal article BMJ · February 26, 2020 OBJECTIVE: To evaluate the effectiveness and cost effectiveness of a complex intervention in primary care that aims to increase uptake of hepatitis C virus (HCV) case finding and treatment. DESIGN: Pragmatic, two armed, practice level, cluster randomised c ... Full text Link to item Cite

StrainHub: a phylogenetic tool to construct pathogen transmission networks.

Journal article Bioinformatics · February 1, 2020 SUMMARY: In exploring the epidemiology of infectious diseases, networks have been used to reconstruct contacts among individuals and/or populations. Summarizing networks using pathogen metadata (e.g. host species and place of isolation) and a phylogenetic ... Full text Link to item Cite

Transformational Coaching: Effect on Process of Care Outcomes and Determinants of Uptake

Report · 2020 High-quality health care is a priority for patients and clinicians alike. Quality improvement (QI) is a framework that guides health system actions to improve the delivery of high-quality health care. Quality improvement activities seek to promote high-qua ... Link to item Cite

Predicting Spatial Risk of Wolf-Cattle Encounters and Depredation

Journal article Rangeland Ecology & Management · January 2020 Full text Cite

Differing climatic mechanisms control transient and accumulated vegetation novelty in Europe and eastern North America.

Journal article Philos Trans R Soc Lond B Biol Sci · December 23, 2019 Understanding the mechanisms of climate that produce novel ecosystems is of joint interest to conservation biologists and palaeoecologists. Here, we define and differentiate transient from accumulated novelty and evaluate four climatic mechanisms proposed ... Full text Link to item Cite

Quantifying trends and uncertainty in prehistoric forest composition in the upper Midwestern United States.

Journal article Ecology · December 2019 Forest ecosystems in eastern North America have been in flux for the last several thousand years, well before Euro-American land clearance and the 20th-century onset of anthropogenic climate change. However, the magnitude and uncertainty of prehistoric veg ... Full text Link to item Cite

Cost-Effectiveness of One-Time Birth Cohort Screening for Hepatitis C as Part of the National Health Service Health Check Program in England.

Journal article Value Health · November 2019 BACKGROUND AND OBJECTIVES: Birth cohort screening for the hepatitis C virus (HCV) has been implemented in the US, but there is little evidence of its cost-effectiveness in England. We aim to evaluate the cost-effectiveness of one-time HCV screening for ind ... Full text Link to item Cite

Machine-learning based reconstructions of primary and secondary climate variables from North American and European fossil pollen data.

Journal article Sci Rep · November 1, 2019 We test several quantitative algorithms as palaeoclimate reconstruction tools for North American and European fossil pollen data, using both classical methods and newer machine-learning approaches based on regression tree ensembles and artificial neural ne ... Full text Link to item Cite

Qualitative Exploration of Engaging Patients as Advisors in a Program of Evidence Synthesis: Cobuilding the Science to Enhance Impact.

Journal article Med Care · October 2019 BACKGROUND: There is an increasing expectation for research to involve patient stakeholders. Yet little guidance exists regarding patient-engaged research in evidence synthesis. Embedded in a learning health care system, the Veteran Affairs Evidence Synthe ... Full text Link to item Cite

Land-use and climatic causes of environmental novelty in Wisconsin since 1890.

Journal article Ecol Appl · October 2019 Multiple global change drivers are increasing the present and future novelty of environments and ecological communities. However, most assessments of environmental novelty have focused only on future climate and were conducted at scales too broad to be use ... Full text Link to item Cite

Self-management of Epilepsy: A Systematic Review.

Journal article Ann Intern Med · July 16, 2019 BACKGROUND: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain. PURPOSE: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwe ... Full text Open Access Link to item Cite

GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences-Risk of bias and indirectness.

Journal article J Clin Epidemiol · July 2019 OBJECTIVES: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing t ... Full text Link to item Cite

GRADE guidelines: 20. Assessing the certainty of evidence in the importance of outcomes or values and preferences-inconsistency, imprecision, and other domains.

Journal article J Clin Epidemiol · July 2019 OBJECTIVE: To provide Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidance for assessing inconsistency, imprecision, and other domains for the certainty of evidence about the relative importance of outcomes. STUDY DESIGN AND ... Full text Link to item Cite

Emergency Department Interventions for Older Adults: A Systematic Review.

Journal article J Am Geriatr Soc · July 2019 OBJECTIVES: To evaluate the effect of emergency department (ED) interventions on clinical, utilization, and care experience outcomes for older adults. DESIGN: A conceptual model informed, protocol-based systematic review. SETTING: Emergency Department (ED) ... Full text Link to item Cite

Chronic hepatitis B virus case-finding in UK populations born abroad in intermediate or high endemicity countries: an economic evaluation.

Journal article BMJ Open · June 28, 2019 OBJECTIVES: The majority (>90%) of new or undiagnosed cases of hepatitis B virus (HBV) in the UK are among individuals born in countries with intermediate or high prevalence levels (≥2%). We evaluate the cost-effectiveness of increased HBV case-finding amo ... Full text Link to item Cite

Anticonvulsants for behavioral and psychological symptoms in dementia: protocol for a systematic review.

Journal article Syst Rev · May 18, 2019 BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are present in a majority of patients with dementia contributing to increased morbidity, health care costs, and caregiver burden. While there are no United States Food and Drug Administra ... Full text Link to item Cite

Late Quaternary vegetation, climate, and fire history of the Southeast Atlantic Coastal Plain based on a 30,000-yr multi-proxy record from White Pond, South Carolina, USA

Journal article Quaternary Research · March 2019 AbstractThe patterns and drivers of late Quaternary vegetation dynamics in the southeastern United States are poorly understood due to low site density, problematic chronologies, and a paucity of independent paleoclimate pr ... Full text Cite

Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.

Journal article Palliat Med · February 2019 BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ... Full text Link to item Cite

Assessing the environmental and dispersal controls onFagus grandifoliadistributions in the Great Lakes region

Journal article Journal of Biogeography · February 2019 AbstractAimThis paper assesses the relative importance of environmental filtering and dispersal limitations as controls on the western range limit ofFagus grandifolia Full text Cite

The potential role of intrinsic processes in generating abrupt and quasi-synchronous tree declines during the Holocene.

Journal article Ecology · February 2019 Multiple abrupt and sometimes near-synchronous declines in tree populations have been detected in the temperate forests of eastern North America and Europe during the Holocene. Traditional approaches to understanding these declines focus on searching for c ... Full text Link to item Cite

Effectiveness of Remote Triage: A Systematic Review

Report · 2019 The US health care system currently faces several challenges including caring for an increasing elderly population, a large numbers of patients with multiple chronic conditions, and an uneven distribution of primary care providers across the country. The f ... Link to item Cite

Pliocene and Eocene provide best analogs for near-future climates.

Journal article Proc Natl Acad Sci U S A · December 26, 2018 As the world warms due to rising greenhouse gas concentrations, the Earth system moves toward climate states without societal precedent, challenging adaptation. Past Earth system states offer possible model systems for the warming world of the coming decad ... Full text Link to item Cite

Telehealth Interventions Designed for Women: an Evidence Map.

Journal article J Gen Intern Med · December 2018 BACKGROUND: Telehealth employs technology to connect patients to the right healthcare resources at the right time. Women are high utilizers of healthcare with gender-specific health issues that may benefit from the convenience and personalization of telehe ... Full text Open Access Link to item Cite

Mechanistic modeling of environmental drivers of woolly mammoth carrying capacity declines on St. Paul Island.

Journal article Ecology · December 2018 On St. Paul Island, a remnant of the Bering Land Bridge, woolly mammoths persisted until 5,600 yr BP with no known predators or competitors, providing a natural system for studying hypothesized environmental drivers of extinction. These include overheating ... Full text Link to item Cite

Below-ground biotic interactions moderated the postglacial range dynamics of trees.

Journal article New Phytol · December 2018 Tree range shifts during geohistorical global change events provide a useful real-world model for how future changes in forest biomes may proceed. In North America, during the last deglaciation, the distributions of tree taxa varied significantly as regard ... Full text Link to item Cite

Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours.

Journal article Breast Cancer Res · October 22, 2018 BACKGROUND: Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian disruptions have been proposed as a contribu ... Full text Link to item Cite

Behavioral health integration model.

Journal article J Gen Intern Med · October 2018 Full text Link to item Cite

Disproportionate magnitude of climate change in United States national parks

Journal article Environmental Research Letters · September 24, 2018 Full text Cite

How will climate novelty influence ecological forecasts? Using the Quaternary to assess future reliability.

Journal article Glob Chang Biol · August 2018 Future climates are projected to be highly novel relative to recent climates. Climate novelty challenges models that correlate ecological patterns to climate variables and then use these relationships to forecast ecological responses to future climate chan ... Full text Link to item Cite

Tropical Protected Areas Under Increasing Threats from Climate Change and Deforestation

Journal article Land · July 28, 2018 Identifying protected areas most susceptible to climate change and deforestation represents critical information for determining conservation investments. Development of effective landscape interventions is required to ensure the preservation and p ... Full text Cite

Interventions That Support or Involve Caregivers or Families of Patients with Traumatic Injury: a Systematic Review.

Journal article J Gen Intern Med · July 2018 BACKGROUND: Almost 40 million family caregivers care for a loved one with severe physical or cognitive impairments. The purpose of this review is to summarize evidence about the benefits of interventions to support or involve family members/caregivers of p ... Full text Link to item Cite

Abrupt Change in Ecological Systems: Inference and Diagnosis.

Journal article Trends Ecol Evol · July 2018 Abrupt ecological changes are, by definition, those that occur over short periods of time relative to typical rates of change for a given ecosystem. The potential for such changes is growing due to anthropogenic pressures, which challenges the resilience o ... Full text Link to item Cite

Assessing agreement among alternative climate change projections to inform conservation recommendations in the contiguous United States.

Journal article Sci Rep · June 21, 2018 Addressing uncertainties in climate vulnerability remains a challenge for conservation planning. We evaluate how confidence in conservation recommendations may change with agreement among alternative climate projections and metrics of climate exposure. We ... Full text Link to item Cite

A new terrestrial palaeoenvironmental record from the Bering Land Bridge and context for human dispersal.

Journal article R Soc Open Sci · June 2018 Palaeoenvironmental records from the now-submerged Bering Land Bridge (BLB) covering the Last Glacial Maximum (LGM) to the present are needed to document changing environments and connections with the dispersal of humans into North America. Moreover, terre ... Full text Link to item Cite

Does information from ClinicalTrials.gov increase transparency and reduce bias? Results from a five-report case series.

Journal article Syst Rev · April 16, 2018 BACKGROUND: We investigated whether information in ClinicalTrials.gov would impact the conclusions of five ongoing systematic reviews. METHOD: We considered five reviews that included 495 studies total. Each review team conducted a search of ClinicalTrials ... Full text Link to item Cite

Management of Menopause Symptoms with Acupuncture: An Umbrella Systematic Review and Meta-Analysis.

Journal article J Altern Complement Med · April 2018 OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatme ... Full text Link to item Cite

TELEHEALTH FOR WOMEN: AN EVIDENCE MAP

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2018 Link to item Cite

Multiresponse algorithms for community‐level modelling: Review of theory, applications, and comparison to species distribution models

Journal article Methods in Ecology and Evolution · April 2018 AbstractCommunity‐level models (CLMs) consider multiple, co‐occurring species in model fitting and are lesser known alternatives to species distribution models (SDMs) for analysing and ... Full text Cite

A retrospective on the accuracy and precision of plotless forest density estimators in ecological studies

Journal article Ecosphere · April 2018 AbstractSampling point‐to‐tree distances is a simple plotless technique for estimating forest density that is readily applied in modern stands and retroactively with historical surveys. Although plotless density estimators ... Full text Cite

Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment.

Journal article J Cell Sci · March 6, 2018 The circadian clock is an autonomous molecular feedback loop inside almost every cell in the body. We have shown that the mammary epithelial circadian clock is regulated by the cellular microenvironment. Moreover, a stiff extracellular matrix dampens the o ... Full text Link to item Cite

Phylogenetic classification of the world's tropical forests.

Journal article Proc Natl Acad Sci U S A · February 20, 2018 Knowledge about the biogeographic affinities of the world's tropical forests helps to better understand regional differences in forest structure, diversity, composition, and dynamics. Such understanding will enable anticipation of region-specific responses ... Full text Link to item Cite

The Neotoma Paleoecology Database, a multiproxy, international, community-curated data resource

Journal article Quaternary Research · January 2018 AbstractThe Neotoma Paleoecology Database is a community-curated data resource that supports interdisciplinary global change research by enabling broad-scale studies of taxon and community diversity, distributions, and dyna ... Full text Cite

Integration of phylogenomics and molecular modeling reveals lineage-specific diversification of toxins in scorpions.

Journal article PeerJ · 2018 Scorpions have evolved a variety of toxins with a plethora of biological targets, but characterizing their evolution has been limited by the lack of a comprehensive phylogenetic hypothesis of scorpion relationships grounded in modern, genome-scale datasets ... Full text Link to item Cite

Behavioral Health Integration into Primary Care: a Microsimulation of Financial Implications for Practices.

Journal article J Gen Intern Med · December 2017 Featured Publication BACKGROUND: New payments from Medicare encourage behavioral health services to be integrated into primary care practice activities. OBJECTIVE: To evaluate the financial impact for primary care practices of integrating behavioral health services. DESIGN: Mi ... Full text Link to item Cite

Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes.

Journal article Diabetes care · December 2017 ObjectiveTo explore prevalent metformin use as a potential moderator of the cardiovascular effects of dipeptidyl peptidase 4 inhibitors (DPP-4i).Research design and methodsWe performed a meta-analysis of the three major cardiovascular out ... Full text Cite

Diagnostic Accuracy of Screening Tests and Treatment for Post-Acute Coronary Syndrome Depression: A Systematic Review.

Journal article Ann Intern Med · November 21, 2017 BACKGROUND: Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. PURPOSE: To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatment ... Full text Link to item Cite

Effects of Wolf Presence on Daily Travel Distance of Range Cattle

Journal article Rangeland Ecology & Management · November 2017 Full text Cite

Climatic history of the northeastern United States during the past 3000 years

Journal article Climate of the Past · October 13, 2017 Abstract. Many ecosystem processes that influence Earth system feedbacks – vegetation growth, water and nutrient cycling, disturbance regimes – are strongly influenced by multidecadal- to millennial-scale climate variations that cannot be directly ... Full text Cite

The phylogeny of extant starfish (Asteroidea: Echinodermata) including Xyloplax, based on comparative transcriptomics.

Journal article Mol Phylogenet Evol · October 2017 Multi-locus phylogenetic studies of echinoderms based on Sanger and RNA-seq technologies and the fossil record have provided evidence for the Asterozoa-Echinozoa hypothesis. This hypothesis posits a sister relationship between asterozoan classes (Asteroide ... Full text Open Access Link to item Cite

Improving vasomotor symptoms; psychological symptoms; and health-related quality of life in peri- or post-menopausal women through yoga: An umbrella systematic review and meta-analysis.

Journal article Complement Ther Med · October 2017 OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about p ... Full text Link to item Cite

Nitrogen losses to the environment following food-based digestate and compost applications to agricultural land.

Journal article Environ Pollut · September 2017 The anaerobic digestion of food waste for energy recovery produces a nutrient-rich digestate which is a valuable source of crop available nitrogen (N). As with any 'new' material being recycled to agricultural land it is important to develop best managemen ... Full text Link to item Cite

Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.

Journal article J Stroke Cerebrovasc Dis · July 2017 BACKGROUND: We investigated the independent association of depression status at 3 and 12 months after stroke and functional decline. METHODS: Data were obtained as part of the multicenter Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) regi ... Full text Link to item Cite

The southern coastal Beringian land bridge: cryptic refugium or pseudorefugium for woody plants during the Last Glacial Maximum?

Journal article Journal of Biogeography · July 2017 AbstractAimThe Bering Land Bridge (BLB) connected Asia and North America during glacial periods, supported a diverse ecosystem ... Full text Cite

Possible pathways and tensions in the food and water nexus

Journal article Earth's Future · May 2017 Abstract“Bottom‐up” field‐based, crop‐hydrological models are used to estimate food production and irrigation water extractions under multiple scenarios of water and nitrogen use and crop yield increases from 2010 to 2050 f ... Full text Cite

Use of mindfulness, meditation and relaxation to treat vasomotor symptoms.

Journal article Climacteric · April 2017 Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS an ... Full text Link to item Cite

NONPHARMACOLOGIC TREATMENTS FOR MENOPAUSE-ASSOCIATED VASOMOTOR SYMPTOMS

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2017 Link to item Cite

Effect of historical land-use and climate change on tree-climate relationships in the upper Midwestern United States.

Journal article Ecol Lett · April 2017 Contemporary forest inventory data are widely used to understand environmental controls on tree species distributions and to construct models to project forest responses to climate change, but the stability and representativeness of contemporary tree-clima ... Full text Link to item Cite

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.

Journal article Ann Rheum Dis · March 2017 OBJECTIVES: The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear diurnal rhythms. However, it is unknown whether IVD tissue c ... Full text Link to item Cite

Spatial occupancy patterns and activity of arid rangeland cattle grazing small riparian pastures.

Journal article Anim Sci J · March 2017 The spatial occupancy patterns and activity of cattle grazing three riparian pastures was investigated in northeastern Oregon using Global Positioning System (GPS) collars logging at 1-sec intervals. Cattle consistently selected plant communities as grazin ... Full text Link to item Cite

Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review.

Journal article Ann Intern Med · February 7, 2017 Featured Publication BACKGROUND: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these p ... Full text Link to item Cite

The Impact of Interventions that Integrate Accelerometers on Physical Activity and Weight Loss: A Systematic Review.

Journal article Ann Behav Med · February 2017 BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitor ... Full text Link to item Cite

Cellular mechano-environment regulates the mammary circadian clock.

Journal article Nat Commun · January 30, 2017 Circadian clocks drive ∼24 h rhythms in tissue physiology. They rely on transcriptional/translational feedback loops driven by interacting networks of clock complexes. However, little is known about how cell-intrinsic circadian clocks sense and respond to ... Full text Link to item Cite

Cannabis

Book section · 2017 Link to item Cite

Respiratory Disease

Book section · 2017 Link to item Cite

Psychosocial

Book section · 2017 Link to item Cite

Injury and Death

Book section · 2017 Link to item Cite

Immunity

Book section · 2017 Link to item Cite

Cancer

Book section · 2017 Link to item Cite

Mental Health

Book section · 2017 Link to item Cite

Correction: Statistically-Estimated Tree Composition for the Northeastern United States at Euro-American Settlement.

Journal article PLoS One · 2017 [This corrects the article DOI: 10.1371/journal.pone.0150087.]. ... Full text Link to item Cite

Correction to ‘Controlled comparison of species- and community-level models across novel climates and communities’

Journal article Proceedings of the Royal Society B: Biological Sciences · August 31, 2016 Full text Cite

Timing and causes of mid-Holocene mammoth extinction on St. Paul Island, Alaska.

Journal article Proc Natl Acad Sci U S A · August 16, 2016 Relict woolly mammoth (Mammuthus primigenius) populations survived on several small Beringian islands for thousands of years after mainland populations went extinct. Here we present multiproxy paleoenvironmental records to investigate the timing, causes, a ... Full text Link to item Cite

Reporting of Sex Effects by Systematic Reviews on Interventions for Depression, Diabetes, and Chronic Pain.

Journal article Ann Intern Med · August 2, 2016 Featured Publication Systematic reviews (SRs) have the potential to contribute uniquely to the evaluation of sex and gender differences (termed "sex effects"). This article describes the reporting of sex effects by SRs on interventions for depression, type 2 diabetes mellitus, ... Full text Link to item Cite

Downscaled and debiased climate simulations for North America from 21,000 years ago to 2100AD.

Journal article Sci Data · July 5, 2016 Increasingly, ecological modellers are integrating paleodata with future projections to understand climate-driven biodiversity dynamics from the past through the current century. Climate simulations from earth system models are necessary to this effort, bu ... Full text Link to item Cite

An overview and discussion of the Patient-Centered Outcomes Research Institute's decision aid portfolio.

Journal article J Comp Eff Res · July 2016 Decision aids (DAs) help patients make informed healthcare decisions in a manner consistent with their values and preferences. Despite their promise, DAs developed with public research dollars are not being implemented and adopted in real-world patient car ... Full text Link to item Cite

Internet Versus DVD Decision Aids for Hip and Knee Osteoarthritis.

Journal article Musculoskeletal Care · June 2016 INTRODUCTION: Decision aids (DAs) can improve multiple decision-making outcomes, but it is not known whether different formats of delivery differ in their effectiveness or acceptability. The present study compared the effectiveness and acceptability of int ... Full text Link to item Cite

Nonpharmacologic, nonherbal management of menopause-associated vasomotor symptoms: an umbrella systematic review (protocol).

Journal article Syst Rev · April 7, 2016 BACKGROUND: Vasomotor symptoms such as hot flashes and night sweats are a common concern of perimenopausal and postmenopausal women and are associated with a decreased quality of life. These symptoms can be effectively managed with hormone therapy, but saf ... Full text Open Access Link to item Cite

An evidence map of yoga for low back pain.

Journal article Complement Ther Med · April 2016 OBJECTIVE: Yoga is being increasingly studied as a treatment strategy for a variety of different clinical conditions, including low back pain (LBP). We set out to conduct an evidence map of yoga for the treatment, prevention and recurrence of acute or chro ... Full text Link to item Cite

Pronounced variations in Fagus grandifolia abundances in the Great Lakes region during the Holocene

Journal article The Holocene · April 2016 Mesic tree species such as Fagus grandifolia and Tsuga canadensis experienced multiple abundance declines in eastern North America during the last 8000 years, but the causes remain unclear. This paper presents a new sub-centennial record of Holocen ... Full text Cite

Controlled comparison of species- and community-level models across novel climates and communities.

Journal article Proc Biol Sci · March 16, 2016 Species distribution models (SDMs) assume species exist in isolation and do not influence one another's distributions, thus potentially limiting their ability to predict biodiversity patterns. Community-level models (CLMs) capitalize on species co-occurren ... Full text Link to item Cite

Evidence Map of Yoga for Depression, Anxiety, and Posttraumatic Stress Disorder.

Journal article J Phys Act Health · March 2016 BACKGROUND: This study describes evidence of yoga's effectiveness for depressive disorders, general anxiety disorder (GAD), panic disorder (PD), and posttraumatic stress disorder (PTSD) in adults. We also address adverse events associated with yoga. METHOD ... Full text Link to item Cite

Seize the Day to Implement Depression Guidelines.

Journal article Ann Intern Med · March 1, 2016 Full text Link to item Cite

Effectiveness of Intermittent Pneumatic Compression Devices for Venous Thromboembolism Prophylaxis in High-Risk Surgical Patients: A Systematic Review.

Journal article J Arthroplasty · February 2016 BACKGROUND: Thromboprophylaxis regimens include pharmacologic and mechanical options such as intermittent pneumatic compression devices (IPCDs). There are a wide variety of IPCDs available, but it is uncertain if they vary in effectiveness or ease of use. ... Full text Link to item Cite

Benchmarking historical CMIP5 plant functional types across the Upper Midwest and Northeastern United States

Journal article Journal of Geophysical Research: Biogeosciences · February 2016 AbstractCentennial‐scale climate‐ecosystem feedbacks are a major source of predictive uncertainty for land‐atmosphere fluxes of energy, carbon, and water. Accurate representations of plant functional type (PFT) distribution ... Full text Cite

Novel and Lost Forests in the Upper Midwestern United States, from New Estimates of Settlement-Era Composition, Stem Density, and Biomass.

Journal article PLoS One · 2016 BACKGROUND: EuroAmerican land-use and its legacies have transformed forest structure and composition across the United States (US). More accurate reconstructions of historical states are critical to understanding the processes governing past, current, and ... Full text Link to item Cite

Statistically-Estimated Tree Composition for the Northeastern United States at Euro-American Settlement.

Journal article PLoS One · 2016 We present a gridded 8 km-resolution data product of the estimated composition of tree taxa at the time of Euro-American settlement of the northeastern United States and the statistical methodology used to produce the product from trees recorded by land su ... Full text Link to item Cite

Modeling Species and Community Responses to Past, Present, and Future Episodes of Climatic and Ecological Change

Book section · December 4, 2015 There is an urgent need to understand species and community responses to climatic and ecological changes to predict biodiversity patterns given anticipated global change. The current distribution of species and the environment provide a limited per ... Full text Cite

The rise of novelty in ecosystems.

Journal article Ecol Appl · December 2015 Rapid and ongoing change creates novelty in ecosystems everywhere, both when comparing contemporary systems to their historical baselines, and predicted future systems to the present. However, the level of novelty varies greatly among places. Here we propo ... Full text Link to item Cite

WITHDRAWN: Antibiotics for acute maxillary sinusitis in adults.

Journal article Cochrane Database Syst Rev · October 16, 2015 Currently, two separate Cochrane reviews, ‘Antibiotics for acute maxillary sinusitis in adults’ and ‘Antibiotics for clinically diagnosed acute rhinosinusitis in adults’ describe the effect of antibiotics for acute rhinosinusitis. Although both Cochrane re ... Full text Link to item Cite

Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review.

Journal article Ann Intern Med · August 4, 2015 Featured Publication BACKGROUND: The use of electronic interventions (e-interventions) may improve treatment of alcohol misuse. PURPOSE: To characterize treatment intensity and systematically review the evidence for efficacy of e-interventions, relative to controls, for reduci ... Full text Link to item Cite

Does This Patient Have Posttraumatic Stress Disorder?: Rational Clinical Examination Systematic Review.

Journal article JAMA · August 4, 2015 IMPORTANCE: Posttraumatic stress disorder (PTSD) is a relatively common mental health condition frequently seen, though often unrecognized, in primary care settings. Identifying and treating PTSD can greatly improve patient health and well-being. OBJECTIVE ... Full text Link to item Cite

Close agreement between pollen‐based and forest inventory‐based models of vegetation turnover

Journal article Global Ecology and Biogeography · August 2015 AbstractAimFossil records are being increasingly used to help understand the consequences of climate change for biodiversity. Pollen records from the late Full text Cite

An estimate of the number of tropical tree species.

Journal article Proc Natl Acad Sci U S A · June 16, 2015 The high species richness of tropical forests has long been recognized, yet there remains substantial uncertainty regarding the actual number of tropical tree species. Using a pantropical tree inventory database from closed canopy forests, consisting of 65 ... Full text Open Access Link to item Cite

Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.

Journal article J Am Geriatr Soc · June 2015 OBJECTIVES: To describe the stability of cognitive impairment, not dementia (CIND) in a longitudinal cohort of primary care veterans. To examine the association between baseline brief cognitive screening tests, demographic and clinical characteristics, and ... Full text Open Access Link to item Cite

Cahokia's emergence and decline coincided with shifts of flood frequency on the Mississippi River.

Journal article Proc Natl Acad Sci U S A · May 19, 2015 Here we establish the timing of major flood events of the central Mississippi River over the last 1,800 y, using floodwater sediments deposited in two floodplain lakes. Shifts in the frequency of high-magnitude floods are mediated by moisture availability ... Full text Link to item Cite

Shared medical appointments for patients with diabetes mellitus: a systematic review.

Journal article J Gen Intern Med · January 2015 OBJECTIVES: Shared medical appointments (SMAs) are an increasingly used system-redesign strategy for improving access to and quality of chronic illness care. We conducted a systematic review of the existing literature on SMA interventions for patients with ... Full text Link to item Cite

Patient Decision Aids: A Case for Certification at the National Level in the United States.

Journal article J Clin Ethics · 2015 Patient decision aids enable patients to be better informed about the potential benefits and harms of their healthcare options. Certification of patient decision aids at the national level in the United States is a critical step towards responsible governa ... Link to item Cite

Utilizing Evidence to Address the Health and Health Care Needs of Veterans.

Journal article N C Med J · 2015 This issue brief focuses on opportunities to address the health needs of our nation's heroes--service members and veterans who have served the United States in the armed forces. Since the North Carolina Medical Journal (NCMJ) last examined this issue in 20 ... Full text Link to item Cite

Defining the spatial patterns of historical land use associated with the indigenous societies of eastern North America

Journal article Journal of Biogeography · December 2014 AbstractAimTo review and synthesize multiple lines of evidence that describe the spatial patterns of land use associated with prehistoric and early historical Native American societies in ... Full text Cite

Water planning and hydro-climatic change in the Murray-Darling Basin, Australia.

Journal article Ambio · December 2014 More than a third of humanity lives in regions with less than 1 million liters of fresh water per person per year. Population growth will increase water demand while climate change in arid and semi-arid areas may reduce water availability. The Murray-Darli ... Full text Link to item Cite

A framework for evaluating the influence of climate, dispersal limitation, and biotic interactions using fossil pollen associations across the late Quaternary

Journal article Ecography · November 2014 Environmental conditions, dispersal lags, and interactions among species are major factors structuring communities through time and across space. Ecologists have emphasized the importance of biotic interactions in determining local patterns of spec ... Full text Cite

Climate refugia: joint inference from fossil records, species distribution models and phylogeography.

Journal article New Phytol · October 2014 Climate refugia, locations where taxa survive periods of regionally adverse climate, are thought to be critical for maintaining biodiversity through the glacial-interglacial climate changes of the Quaternary. A critical research need is to better integrate ... Full text Link to item Cite

Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

Journal article Ann Intern Med · July 15, 2014 Featured Publication BACKGROUND: Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model ma ... Full text Link to item Cite

Does this patient have generalized anxiety or panic disorder?: The Rational Clinical Examination systematic review.

Journal article JAMA · July 2, 2014 Featured Publication IMPORTANCE: In primary care settings, generalized anxiety disorder (GAD) and panic disorder are common but underrecognized illnesses. Identifying accurate and feasible screening instruments for GAD and panic disorder has the potential to improve detection ... Full text Link to item Cite

Pharmacologic and behavioral interventions to improve cardiovascular risk factors in adults with serious mental illness: a systematic review and meta-analysis.

Journal article J Clin Psychiatry · May 2014 OBJECTIVE: Individuals with serious mental illness have high rates of cardiovascular disease (CVD) risk factors and mortality. This systematic review was conducted to evaluate pharmacologic and behavioral interventions to reduce CVD risk in adults with ser ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis in adults.

Journal article Cochrane Database Syst Rev · February 11, 2014 BACKGROUND: Sinusitis is one of the most common diagnoses among adults in ambulatory care, accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. However, the role of antibiotics for sinusitis is controversial. OBJECTIVES: To assess th ... Full text Link to item Cite

Future no‐analogue vegetation produced by no‐analogue combinations of temperature and insolation

Journal article Global Ecology and Biogeography · February 2014 AbstractAimProjections of future climate change suggest that regional climates may evolve to states that are unlike any climate regime found on Earth today. These climates will impose nove ... Full text Cite

Model systems for a no-analog future: species associations and climates during the last deglaciation.

Book section · September 2013 As the earth system moves to a novel state, model systems (experimental, observational, paleoecological) are needed to assess and improve the predictive accuracy of ecological models under environments with no contemporary analog. In recent years, we have ... Full text Link to item Cite

Linking abundances of the dung fungus porormiella to the density of bison: implications for assessing grazing by megaherbivores in palaeorecords

Journal article Journal of Ecology · September 2013 SummaryMegaherbivores likely had important influences on past vegetation dynamics, just as they do in modern ecosystems. The exact nature of megaherbivores' role can be studied using a ... Full text Cite

Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review.

Journal article Ann Intern Med · August 20, 2013 BACKGROUND: Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR). New oral anticoagulants (NOACs), including direct thrombin inhibitors and factor Xa inhibitors, are ... Full text Link to item Cite

An evidence synthesis of care models to improve general medical outcomes for individuals with serious mental illness: a systematic review.

Journal article J Clin Psychiatry · August 2013 OBJECTIVE: To conduct a systematic review of studies of interventions that integrated medical and mental health care to improve general medical outcomes in individuals with serious mental illness. DATA SOURCES: English-language publications in MEDLINE (via ... Full text Link to item Cite

Space can substitute for time in predicting climate-change effects on biodiversity.

Journal article Proc Natl Acad Sci U S A · June 4, 2013 "Space-for-time" substitution is widely used in biodiversity modeling to infer past or future trajectories of ecological systems from contemporary spatial patterns. However, the foundational assumption--that drivers of spatial gradients of species composit ... Full text Link to item Cite

Climatic and biotic velocities for woody taxa distributions over the last 16 000 years in eastern North America.

Journal article Ecol Lett · June 2013 We estimated the latitudinal velocity (km/decade) of northern and southern boundaries of core distributions for 30 woody taxa over the last 16 000 years (biotic velocities) using networks of fossil pollen records, and compared these with climate velocities ... Full text Link to item Cite

Modeling the climatic drivers of spatial patterns in vegetation composition since the Last Glacial Maximum

Journal article Ecography · April 2013 Projecting the future composition and function of communities is a major challenge, and there is an urgent need to develop, improve, and test the predictive capacity of ecological models under different climate states. We tested the effect of clima ... Full text Cite

Global insights into water resources, climate change and governance

Journal article Nature Climate Change · April 2013 Full text Cite

Uptake of Web-based clinical resources from the MacArthur Initiative on Depression and Primary Care.

Journal article Community Ment Health J · April 2013 This study assessed the usability and desired enhancements for the MacArthur Foundation's Depression and Primary Care (MDPC) Web site to determine if resources for integrated depression care that are disseminated through the Web site are incorporated into ... Full text Link to item Cite

The ice age ecologist: testing methods for reserve prioritization during the last global warming

Journal article Global Ecology and Biogeography · March 2013 ABSTRACTAim  We play the role of an ice age ecologist (IAE) charged with conserving biodiversity during the climate changes accompanying the ... Full text Cite

The patient centered medical home. A systematic review.

Journal article Ann Intern Med · February 5, 2013 Featured Publication BACKGROUND: The patient-centered medical home (PCMH) describes mechanisms for organizing primary care to provide high quality care across the full range of individuals' health care needs.It is being widely implemented by provider organizations and third pa ... Full text Link to item Cite

ECG-based signal analysis technologies for evaluating patients with acute coronary syndrome: a systematic review.

Journal article J Electrocardiol · 2013 BACKGROUND/OBJECTIVES: Timely identification of cardiac ischemia is critical in patients with acute coronary syndrome (ACS). The first test is often the standard, resting 12-lead ECG. Given its limitations, signal analysis enhancements have been proposed. ... Full text Link to item Cite

Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review.

Journal article Ann Intern Med · December 4, 2012 BACKGROUND: New oral anticoagulants (NOACs), including direct thrombin inhibitors (DTIs) and factor Xa (FXa) inhibitors, are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE). PURPOSE: To compa ... Full text Link to item Cite

TCT-788 The EVEREST II Randomized Controlled Trial (RCT): Three Year Outcomes

Conference Journal of the American College of Cardiology · October 2012 Full text Cite

Effect of clinical decision-support systems: a systematic review.

Journal article Ann Intern Med · July 3, 2012 BACKGROUND: Despite increasing emphasis on the role of clinical decision-support systems (CDSSs) for improving care and reducing costs, evidence to support widespread use is lacking. PURPOSE: To evaluate the effect of CDSSs on clinical outcomes, health car ... Full text Link to item Cite

Closing the quality gap: revisiting the state of the science (vol. 2: the patient-centered medical home).

Journal article Evid Rep Technol Assess (Full Rep) · July 2012 OBJECTIVES: As part of the Closing the Quality Gap: Revisiting the State of the Science series of the Agency for Healthcare Research and Quality (AHRQ), this systematic review sought to identify completed and ongoing evaluations of the comprehensive patien ... Link to item Cite

THE PATIENT-CENTERED MEDICAL HOME, A SYSTEMATIC REVIEW

Journal article JOURNAL OF GENERAL INTERNAL MEDICINE · July 1, 2012 Link to item Cite

Projected vegetation changes for the American Southwest: combined dynamic modeling and bioclimatic-envelope approach.

Journal article Ecol Appl · June 2012 This study focuses on potential impacts of 21st century climate change on vegetation in the Southwest United States, based on debiased and interpolated climate projections from 17 global climate models used in the Fourth Assessment Report of the Intergover ... Full text Link to item Cite

Depression and antidepressant use after stroke and transient ischemic attack.

Journal article Stroke · June 2012 BACKGROUND AND PURPOSE: Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS: This study was a secondary analysis of a p ... Full text Link to item Cite

Screening for cognitive impairment: comparing the performance of four instruments in primary care.

Journal article J Am Geriatr Soc · June 2012 OBJECTIVES: To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia. DESIGN: A cross-sectional comparison of cognitive screening tests to an indepe ... Full text Link to item Cite

No‐analog climates and shifting realized niches during the late quaternary: implications for 21st‐century predictions by species distribution models

Journal article Global Change Biology · May 2012 AbstractEmpirically derived species distributions models (SDMs) are increasingly relied upon to forecast species vulnerabilities to future climate change. Howeve ... Full text Cite

Conclusion

Journal article International Journal of Technology and Design Education · May 2012 Full text Cite

Influences of climate, cattle density, and lake morphology on Sporormiella abundances in modern lake sediments in the US Great Plains

Journal article The Holocene · April 2012 Sporormiella, a genus of coprophilous fungus, is increasingly used as a qualitative proxy for megafaunal density. Decreased spore abundances in Late-Pleistocene and Holocene sediments are thought to signal prehistoric megafaunal population declines ... Full text Cite

Psychometric characteristics of outcome measures in juvenile idiopathic arthritis: a systematic review.

Journal article Arthritis Care Res (Hoboken) · April 2012 OBJECTIVE: To review the performance characteristics of the instruments most commonly used to measure clinical outcomes in juvenile idiopathic arthritis (JIA), including global assessments, articular indices, functional/disability assessments, and quality ... Full text Link to item Cite

Enabling health care decisionmaking through clinical decision support and knowledge management.

Journal article Evid Rep Technol Assess (Full Rep) · April 2012 OBJECTIVES: To catalogue study designs used to assess the clinical effectiveness of CDSSs and KMSs, to identify features that impact the success of CDSSs/KMSs, to document the impact of CDSSs/KMSs on outcomes, and to identify knowledge types that can be in ... Link to item Cite

Treatment of mild to moderate sinusitis.

Journal article Arch Intern Med · March 26, 2012 BACKGROUND: The National Physicians Alliance (NPA)-initiated a project titled "Promoting Good Stewardship in Clinical Practice" to develop a list of the "Top 5" activities in primary care, where changes in practice could lead simultaneously to higher quali ... Full text Link to item Cite

Systematic review of disease-modifying antirheumatic drugs for juvenile idiopathic arthritis.

Journal article BMC Pediatr · March 15, 2012 BACKGROUND: Treatment of juvenile idiopathic arthritis (JIA) with disease-modifying antirheumatic drugs (DMARDs) may improve outcomes compared to conventional therapy (e.g., non-steroidal anti-inflammatory drugs, intra-articular corticosteroids). The purpo ... Full text Link to item Cite

Vegetation history in central Kentucky and Tennessee (USA) during the last glacial and deglacial periods

Journal article Quaternary Research · March 2012 AbstractKnowledge about vegetation dynamics during the last glacial and deglacial periods in southeastern North America is under-constrained owing to low site density and problematic chronologies. New pollen records from tw ... Full text Cite

Smoking cessation interventions for patients with depression: a systematic review and meta-analysis.

Journal article J Gen Intern Med · March 2012 OBJECTIVES: We conducted a systematic literature review of smoking cessation interventions for patients with histories of depressive disorders or current significant depressive symptoms. We examined the comparative effectiveness of smoking cessation strate ... Full text Link to item Cite

Paleoecoinformatics: applying geohistorical data to ecological questions.

Journal article Trends Ecol Evol · February 2012 Paleoecoinformatics, the development and use of paleoecological databases and tools, has a strong tradition of community support, and is rapidly growing as new tools bring new opportunities to advance understanding of ecological and evolutionary dynamics, ... Full text Link to item Cite

Brief psychotherapy for depression: a systematic review and meta-analysis.

Journal article Int J Psychiatry Med · 2012 OBJECTIVE: Because evidence-based psychotherapies of 12 to 20 sessions can be perceived as too lengthy and time intensive for the treatment of depression in primary care, a number of studies have examined abbreviated psychotherapy protocols. The purpose of ... Full text Link to item Cite

GRADE guidelines 6. Rating the quality of evidence--imprecision.

Journal article J Clin Epidemiol · December 2011 GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal primary approach to decisions regarding imprecision. For practice guidelines, rating down the quality of evidence (i.e., confidence in estimates of effect) is required i ... Full text Link to item Cite

GRADE guidelines: 5. Rating the quality of evidence--publication bias.

Journal article J Clin Epidemiol · December 2011 In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low-quality evidence, but both can be rated down if a body of evidence is associated with a high risk of publication bias. Even when individual studies inc ... Full text Link to item Cite

Risk factors and preventive interventions for Alzheimer disease: state of the science.

Journal article Arch Neurol · September 2011 BACKGROUND: Numerous studies have investigated risk factors for Alzheimer disease (AD). However, at a recent National Institutes of Health State-of-the-Science Conference, an independent panel found insufficient evidence to support the association of any m ... Full text Link to item Cite

2011 APSA Teaching and Learning Conference Track Summaries

Journal article PS: Political Science & Politics · July 2011 Assessment, particularly program assessment, has reached a new height in the APSA with the publication of an edited volume, Assessment in Political Science Full text Cite

Examination of the utility of psychotherapy for patients with treatment resistant depression: a systematic review.

Journal article J Gen Intern Med · June 2011 OBJECTIVE: To examine the utility of psychotherapy in managing treatment resistant depression. DATA SOURCES: PubMed, PsycInfo, Embase, Cochrane Registry of Controlled Clinical Trials, article bibliographies. REVIEW METHODS: Eligible articles had to be in E ... Full text Link to item Cite

Extrinsic and intrinsic forcing of abrupt ecological change: case studies from the late Quaternary

Journal article Journal of Ecology · May 2011 Summary1. Abrupt changes and regime shifts are common phenomena in terrestrial ecological records spanning centuries to millennia, thus offering a rich opportunity to study the patterns and drivers o ... Full text Cite

Grading quality of evidence and strength of recommendations in clinical practice guidelines part 3 of 3. The GRADE approach to developing recommendations.

Journal article Allergy · May 2011 This is the third and last article in the series about the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to grading the quality of evidence and the strength of recommendations in clinical practice guidelines and its app ... Full text Link to item Cite

Acceptability of dementia screening in primary care patients.

Journal article Int J Geriatr Psychiatry · April 2011 OBJECTIVES: To determine the acceptability of dementia screening in two populations of older adults in different primary care settings. METHODS: Cross-sectional study of consecutive patients presenting for primary care appointments in the Duke University H ... Full text Link to item Cite

GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias).

Journal article J Clin Epidemiol · April 2011 In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low-quality evidence, but both can be rated down if most of the relevant evidence comes from studies that suffer from a high risk of bias. Well-established ... Full text Link to item Cite

Late Quaternary variations in tree cover at the northern forest-tundra ecotone

Journal article Journal of Geophysical Research · February 11, 2011 Full text Cite

GRADE guidelines: 6. Rating the quality of evidence-imprecision

Journal article Chinese Journal of Evidence Based Medicine · January 1, 2011 Cite

Complex seasonal cycle of ecohydrology in the Southwest United States

Journal article Journal of Geophysical Research: Biogeosciences · December 2010 This study investigates the causes for, and distribution of, unimodal versus bimodal seasonal cycle of vegetation greenness in the Southwest United States using extensive site observations, climate data, satellite data, and the Lund‐Potsdam‐Jena (L ... Full text Cite

Authors' reply

Journal article BMJ · October 19, 2010 Full text Cite

Percutaneous heart valve replacement for aortic stenosis: state of the evidence.

Journal article Ann Intern Med · September 7, 2010 Surgical aortic valve replacement (SAVR) is the only treatment known to improve symptoms and survival in patients with severe, symptomatic aortic stenosis. Perioperative mortality, however, is high among many patients for whom SAVR may be indicated. Percut ... Full text Link to item Cite

Taking healthcare interventions from trial to practice.

Journal article BMJ · August 13, 2010 Featured Publication Full text Link to item Cite

Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

Journal article Ann Intern Med · August 3, 2010 Featured Publication BACKGROUND: Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline. PURPOSE: To summarize evidence about putative risk and protective factors for cognitive decline in older adults and t ... Full text Link to item Cite

Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study.

Journal article J Clin Oncol · July 1, 2010 PURPOSE: To determine whether adding bevacizumab, with or without mitomycin, to capecitabine monotherapy improves progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) in an open-label, three-arm randomized trial. PATIENTS AN ... Full text Link to item Cite

Preventing Alzheimer's disease and cognitive decline.

Journal article Evid Rep Technol Assess (Full Rep) · April 2010 OBJECTIVES: To assess whether previous research on purported risk or protective factors for Alzheimer's disease (AD) and cognitive decline is of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical interventi ... Link to item Cite

Globally downscaled climate projections for assessing the conservation impacts of climate change.

Journal article Ecol Appl · March 2010 Assessing the potential impacts of 21st-century climate change on species distributions and ecological processes requires climate scenarios with sufficient spatial resolution to represent the varying effects of climate change across heterogeneous physical, ... Full text Link to item Cite

Impact of subclinical inflammation on the development of interstitial fibrosis and tubular atrophy in kidney transplant recipients.

Journal article Am J Transplant · March 2010 Our aim was to study the impact of subclinical inflammation on the development of interstitial fibrosis and tubular atrophy (IF/TA) on a 1-year protocol biopsy in patients on rapid steroid withdrawal (RSW). A total of 256 patients were classified based on ... Full text Link to item Cite

The contribution of intrinsic and extrinsic apoptotic pathways in Th2-mediated inflammation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2010 Link to item Cite

IRF4 expression in dendritic cells regulates Th2 immune responses

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2010 Link to item Cite

Mal-development of the penis and loss of fertility in male rats treated neonatally with female contraceptive 17alpha-ethinyl estradiol: a dose-response study and a comparative study with a known estrogenic teratogen diethylstilbestrol.

Journal article Toxicol Sci · December 2009 The objectives of this study were to find a minimal dose of 17alpha-ethinyl estradiol (EE) that is detrimental to the developing penis and fertility and to compare estrogenic effects between EE and diethylstilbestrol (DES). Neonatal rats received EE at 10 ... Full text Link to item Cite

Pleistocene megafaunal collapse, novel plant communities, and enhanced fire regimes in North America.

Journal article Science · November 20, 2009 Although the North American megafaunal extinctions and the formation of novel plant communities are well-known features of the last deglaciation, the causal relationships between these phenomena are unclear. Using the dung fungus Sporormiella and other pal ... Full text Link to item Cite

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies

Journal article Chinese Journal of Evidence Based Medicine · August 28, 2009 Cite

Marketing off-label uses: Shady practices within a gray market

Journal article Psychiatric Times · August 1, 2009 Cite

Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions.

Journal article Allergy · May 2009 The GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) approach provides guidance to grading the quality of underlying evidence and the strength of recommendations in health care. The GRADE system's conceptual underpinnings allow for ... Full text Link to item Cite

IMPACT OF WEIGHT LOSS ON SEXUAL FUNCTION IN OBESE WOMEN

Conference The Journal of Urology · April 2009 Full text Cite

Did stress to the barrier influence the development of pigmentation in humans?

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 2009 Link to item Cite

How reviews covered the unfolding scientific story of gabapentin for bipolar disorder.

Journal article Gen Hosp Psychiatry · 2009 BACKGROUND: Despite the lack of randomized controlled trials (RCTs), gabapentin use increased rapidly in the 1990s for mental health conditions. Subsequent RCTs did not demonstrate efficacy for bipolar disorder (BD). We examined the characteristics of revi ... Full text Link to item Cite

Developing a national dissemination plan for collaborative care for depression: QUERI Series.

Journal article Implement Sci · December 31, 2008 Featured Publication BACKGROUND: Little is known about effective strategies for disseminating and implementing complex clinical innovations across large healthcare systems. This paper describes processes undertaken and tools developed by the U.S. Department of Veterans Affairs ... Full text Link to item Cite

RESPECT-Mil: feasibility of a systems-level collaborative care approach to depression and post-traumatic stress disorder in military primary care.

Journal article Mil Med · October 2008 BACKGROUND: U.S. military ground forces report high rates of war-related traumatic stressors, posttraumatic stress disorder (PTSD), and depression following deployment in support of recent armed conflicts in Iraq and Afghanistan. Affected service members d ... Full text Link to item Cite

Generation and Recombination Carrier Lifetimes in 4H SiC Epitaxial Wafers

Conference Materials Science Forum · September 26, 2008 Compared to silicon, there have been relatively few comparative studies of recombination and carrier lifetimes in SiC. For the first time, both generation and recombination carrier lifetimes are reported from the same areas in 20 m thick 4H SiC n- ... Full text Cite

Antibiotics for acute maxillary sinusitis.

Journal article Cochrane database of systematic reviews (Online) · June 17, 2008 BACKGROUND: Expert opinions vary on the appropriate role of antibiotics for sinusitis, one of the most commonly diagnosed conditions among adults in ambulatory care. OBJECTIVES: We examined whether antibiotics are effective in treating acute sinusitis, and ... Cite

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies.

Journal article BMJ · May 17, 2008 Featured Publication The GRADE system can be used to grade the quality of evidence and strength of recommendations for diagnostic tests or strategies. This article explains how patient-important outcomes are taken into account in this process ... Full text Link to item Cite

Comparison of approaches to shielding of ADR magnets

Conference Cryogenics · May 1, 2008 An important consideration in the use of magnets in adiabatic demagnetization refrigeration (ADR) applications is shielding of the other instruments in the vicinity of the superconducting magnets. Shielding without proper optimization can add unnecessary w ... Full text Cite

Influence of Microgravity Environment on Root Growth, Soluble Sugars, and Starch Concentration of Sweetpotato Stem Cuttings.

Journal article J Am Soc Hortic Sci · May 1, 2008 Because sweetpotato [Ipomoea batatas (L.) Lam.] stem cuttings regenerate very easily and quickly, a study of their early growth and development in microgravity could be useful to an understanding of morphological changes that might occur under such conditi ... Link to item Cite

Collaborative mental health and primary care for bipolar disorder.

Journal article J Psychiatr Pract · May 2008 This article discusses the use of integrated care models, in particular, collaborative care, in the treatment of bipolar disorder. Dr. Williams first discusses how care delivered via a collaboration between primary care and psychiatric providers has the po ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal article Cochrane Database Syst Rev · April 16, 2008 BACKGROUND: Expert opinions vary on the appropriate role of antibiotics for sinusitis, one of the most commonly diagnosed conditions among adults in ambulatory care. OBJECTIVES: We examined whether antibiotics are effective in treating acute sinusitis, and ... Full text Link to item Cite

Gabapentin in the treatment of mental illness: the echo chamber of the case series.

Journal article J Psychiatr Pract · March 2008 BACKGROUND: Bipolar disorder is a common and debilitating psychiatric illness. Several antiepileptic drugs (AEDs) have been approved for the treatment of bipolar disorder. Gabapentin gained a large market share of AED use in the late 1990s in spite of a la ... Full text Link to item Cite

Effectiveness of antiepileptic drugs for the treatment of bipolar disorder: findings from a systematic review.

Journal article J Psychiatr Pract · March 2008 Bipolar disorder is characterized by chronic and recurrent symptoms including mania, hypomania, and depressive and mixed episodes, with approximately 5.7 million Americans over age 18, or 2.6% of the U.S. population, suffering from the illness. The prevale ... Full text Link to item Cite

Leaf area index for northern and eastern North America at the Last Glacial Maximum: a data–model comparison

Journal article Global Ecology and Biogeography · January 2008 ABSTRACTAim  To estimate the effects of full‐glacial atmospheric CO2 concentrations and climate upon leaf area index (LAI), using both global vegetation models and palaeoecologica ... Full text Cite

AGRICULTURE

Book section · 2008 Link to item Cite

Perspectives on Energy-Fisheries in Cook Inlet: Audience Questions and Answers

Conference NORTH ALEUTIAN BASIN ENERGY-FISHERIES, WORKSHOP PROCEEDINGS · 2008 Link to item Cite

Benefits from the Oil Industry on the Kenai Peninsula

Conference NORTH ALEUTIAN BASIN ENERGY-FISHERIES, WORKSHOP PROCEEDINGS · 2008 Link to item Cite

Impact of pain on the outcomes of depression treatment: results from the RESPECT trial.

Journal article Pain · January 2008 OBJECTIVE: Pain is prevalent in patients with depression. The purpose of this study was to determine the impact of pain on depression treatment outcomes. METHODS: Data was analyzed from a randomized controlled trial comparing a collaborative care intervent ... Full text Link to item Cite

Identifying depressed older adults in primary care: a secondary analysis of a multisite randomized controlled trial.

Journal article Prim Care Companion J Clin Psychiatry · 2008 OBJECTIVE: To determine whether a subset of depressive symptoms could be identified to facilitate diagnosis of depression in older adults in primary care. METHOD: Secondary analysis was conducted on 898 participants aged 60 years or older with major depres ... Full text Link to item Cite

The challenges of multimorbidity from the patient perspective.

Journal article J Gen Intern Med · December 2007 BACKGROUND: Although multiple co-occurring chronic illnesses within the same individual are increasingly common, few studies have examined the challenges of multimorbidity from the patient perspective. OBJECTIVE: The aim of this study is to examine the sel ... Full text Link to item Cite

Novel climates, no-analog communities, and ecological surprises

Journal article Frontiers in Ecology and the Environment · November 2007 Full text Cite

Dementia and Activities of Daily Living—Reply

Journal article JAMA · October 3, 2007 Full text Cite

Screening for dementia in primary care

Journal article Journal of Clinical Outcomes Management · September 1, 2007 Cite

Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand.

Journal article Inorg Chem · July 23, 2007 The synthesis of bifunctional dinuclear platinum complexes, [{PtCl(dach)}(2)-mu-Y](n+)Cl(n) (1-3; Y = H(2)N(CH(2))(3)NH(2)(CH(2))(4)NH(2), H(2)N(CH(2))(6)NH(2)(CH(2))(6)NH(2), and H(2)N(CH(2))(6)NH(2)(CH(2))(2)NH(2)(CH(2))(6)NH(2), respectively; Figure 1) ... Full text Link to item Cite

Does this patient have dementia?

Journal article JAMA · June 6, 2007 CONTEXT: While as many as 5 million individuals in the United States have dementia, many others have memory complaints. Brief tests to screen for cognitive impairment could help guide dementia diagnosis. OBJECTIVE: To review the literature concerning the p ... Full text Link to item Cite

Best practices: comparing medication treatments in mental health: drug class reviews and policy challenges.

Journal article Psychiatr Serv · June 2007 Advances in the number and type of medications for psychiatric illness have substantially aided physicians. However, as the number of available medications within a class increases, so does the complexity in decision making for provider and patient. System ... Full text Link to item Cite

Projected distributions of novel and disappearing climates by 2100 AD.

Journal article Proc Natl Acad Sci U S A · April 3, 2007 Key risks associated with projected climate trends for the 21st century include the prospects of future climate states with no current analog and the disappearance of some extant climates. Because climate is a primary control on species distributions and e ... Full text Link to item Cite

Performance indicators for bipolar disorder: Development and feasibility testing

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2007 Link to item Cite

Sustainable impact of a primary care depression intervention.

Journal article J Am Board Fam Med · 2007 BACKGROUND: Re-Engineering Systems for Primary Care Treatment of Depression (RESPECT-D) sought to improve patient outcomes by disseminating the 3-component model of depression management. The purpose of this study was to determine whether an integrated mod ... Full text Link to item Cite

Systematic review of multifaceted interventions to improve depression care.

Journal article Gen Hosp Psychiatry · 2007 OBJECTIVE: Depression is a prevalent high-impact illness with poor outcomes in primary care settings. We performed a systematic review to determine to what extent multifaceted interventions improve depression outcomes in primary care and to define key elem ... Full text Link to item Cite

A fidelity measure for integrated management of depression in primary care.

Journal article Med Care · November 2006 BACKGROUND: Integrated models of primary care depression management improve outcomes. Subsequent dissemination efforts and their evaluation need a fidelity measure. OBJECTIVES: We sought to develop and validate a fidelity measure using data gathered during ... Full text Link to item Cite

Reducing suicidal ideation in depressed older primary care patients.

Journal article J Am Geriatr Soc · October 2006 OBJECTIVES: To determine the effect of a primary care-based collaborative care program for depression on suicidal ideation in older adults. DESIGN: Randomized, controlled trial. SETTING: Eighteen diverse primary care clinics. PARTICIPANTS: One thousand eig ... Full text Link to item Cite

Dissemination of evidence-based mental health interventions: importance to the trauma field.

Journal article J Trauma Stress · October 2006 Randomized controlled trials have established the efficacy of psychotherapy and medication treatments for posttraumatic stress disorder (PTSD). Despite these advancements, many individuals do not receive guideline-concordant PTSD care. In an effort to adva ... Full text Link to item Cite

Crack cocaine causing fatal vasoconstriction of the aorta.

Journal article J Emerg Med · August 2006 Cocaine is the most powerful central nervous stimulant found in nature. All forms of cocaine cause tachycardia and vasoconstriction. A smokable, rapidly reacting form of cocaine base, "crack," is highly addictive. Smoking crack introduces a high concentrat ... Full text Link to item Cite

Polyomavirus-associated nephropathy: update on antiviral strategies.

Conference Transpl Infect Dis · June 2006 Polyomavirus-associated nephropathy (PVAN) is a major complication of kidney transplantation. Many centers respond to PVAN by reducing immunosuppression. Concern over precipitating rejection, as well as situations in which some PVAN-afflicted individuals h ... Full text Link to item Cite

Telepathy: maximizing resident exposure to surgical pathology decision making.

Journal article Am J Surg · April 2006 BACKGROUND: General surgery residents are often not present for the critical intraoperative discussion between surgeon and pathologist regarding surgical pathology findings. METHODS: A prospective pilot study analyzed general surgery resident exposure to s ... Full text Link to item Cite

Living donor liver transplantation for hepatitis C-related cirrhosis: no difference in histological recurrence when compared to deceased donor liver transplantation recipients.

Conference Liver Transpl · April 2006 The question of possible earlier and more aggressive recurrence of hepatitis C virus (HCV) infection after living donor liver transplantation (LDLT) compared to deceased donor liver transplantation (DDLT) remains unanswered. To address this issue we retros ... Full text Link to item Cite

Observed Vegetation–Climate Feedbacks in the United States*

Journal article Journal of Climate · March 1, 2006 AbstractObserved vegetation feedbacks on temperature and precipitation are assessed across the United States using satellite-based fraction of photosynthetically active radiation (FPAR) and monthly climate d ... Full text Cite

Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care.

Journal article BMJ · February 4, 2006 OBJECTIVE: To determine the long term effectiveness of collaborative care management for depression in late life. DESIGN: Two arm, randomised, clinical trial; intervention one year and follow-up two years. SETTING: 18 primary care clinics in eight US healt ... Full text Link to item Cite

Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes and depression.

Journal article Diabetes Care · February 2006 Featured Publication OBJECTIVE: To determine the incremental cost-effectiveness and net benefit of a depression collaborative care program compared with usual care for patients with diabetes and depression. RESEARCH DESIGN AND METHODS: This article describes a preplanned subgr ... Full text Link to item Cite

The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report.

Journal article J Clin Psychopharmacol · February 2006 OBJECTIVE: Although a growing body of research suggests that atypical neuroleptic medications are efficacious in the treatment of cocaine addiction among individuals with schizophrenia, more rigorously controlled trials are needed. To extend this research, ... Full text Link to item Cite

Concurrent antiviral and immunosuppressive activities of leflunomide in vivo.

Conference Am J Transplant · January 2006 We previously reported that the immunosuppressive malononitrileamides leflunomide and FK778 exert antiviral activity against cytomegalovirus (CMV). In the current investigation, we tested the hypothesis that leflunomide exerts concurrent antiviral activity ... Full text Link to item Cite

Assessment of uterine wall thickness and position of the vascular plexus in the deep myometrium: implications for the measurement of depth of myometrial invasion of endometrial carcinomas.

Journal article Int J Gynecol Pathol · January 2006 Accurate discrimination between FIGO stages IB and IC endometrial carcinomas has important prognostic and therapeutic implications, but depth of invasion as a percentage of myometrial thickness can be difficult to ascertain. In such cases, pathologists oft ... Full text Link to item Cite

Polyoma virus infection of renal allografts: relationships of the distribution of viral infection, tubulointerstitial inflammation, and fibrosis suggesting viral interstitial nephritis in untreated disease.

Journal article Hum Pathol · December 2005 Whether polyoma virus (PV) infection of renal allografts induces an antiviral or antigraft immune reaction is unclear. By examination of the relationships of tubular PV to graft inflammation and scarring, this study sought histological evidence of viral in ... Full text Link to item Cite

Cost-effectiveness of improving primary care treatment of late-life depression.

Journal article Arch Gen Psychiatry · December 2005 CONTEXT: Depression is a leading cause of functional impairment in elderly individuals and is associated with high medical costs, but there are large gaps in quality of treatment in primary care. OBJECTIVE: To determine the incremental cost-effectiveness o ... Full text Link to item Cite

Simulated 21st century changes in regional water balance of the Great Lakes region and links to changes in global temperature and poleward moisture transport

Journal article Geophysical Research Letters · September 2005 Simulations from eight climate models and two greenhouse gas emission scenarios are used to investigate changes in the hydrologic budget of the Great Lakes region of North America and the links to large‐scale hemispheric/global changes. The ensembl ... Full text Cite

Diversity and productivity of plant communities across the Inland Northwest, USA.

Journal article Oecologia · May 2005 No definitive explanation for the form of the relationship between species diversity and ecosystem productivity exists nor is there agreement on the mechanisms linking diversity and productivity across scales. Here, we examine changes in the form of the di ... Full text Link to item Cite

The use of leflunomide in virally infected transplant patients.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 2005 Link to item Cite

Improving depression care for older, minority patients in primary care.

Journal article Med Care · April 2005 OBJECTIVE: Few older minorities receive adequate treatment of depression in primary care. This study examines whether a collaborative care model for depression in primary care is as effective in older minorities as it is in nonminority elderly patients in ... Full text Link to item Cite

Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system.

Journal article BMC Health Serv Res · March 23, 2005 Featured Publication BACKGROUND: Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key short ... Full text Link to item Cite

Leflunomide for polyomavirus type BK nephropathy.

Journal article N Engl J Med · March 17, 2005 Full text Link to item Cite

Anthropogenic impacts upon plant species richness and net primary productivity in California

Journal article Ecology Letters · February 2005 AbstractWe assess the importance of anthropogenic land‐use, altered productivity, and species invasions for observed productivity–richness relationships in California. To this end, we model net primary productivity (NPP) Full text Cite

Adherence to mental health treatment in a primary care clinic.

Journal article J Am Board Fam Pract · 2005 BACKGROUND: Patient nonadherence is common for the standard mental health treatments in primary care: antidepressants and referrals to specialty mental health treatment. This is one of few studies to prospectively identify predictors of nonadherence. METHO ... Full text Link to item Cite

Suicidal ideation and risk levels among primary care patients with uncomplicated depression.

Journal article Ann Fam Med · 2005 PURPOSE: We investigated the prevalence, severity, and course of passive and active suicidal ideation occurring in primary care patients with an uncomplicated depressive disorder. METHODS: We studied suicidal ideation experienced by patients recruited in 6 ... Full text Link to item Cite

Impact of comorbid panic and posttraumatic stress disorder on outcomes of collaborative care for late-life depression in primary care.

Journal article Am J Geriatr Psychiatry · January 2005 OBJECTIVE: Comorbid anxiety disorders may result in worse depression treatment outcomes. The authors evaluated the effect of comorbid panic disorder and posttraumatic stress disorder (PTSD) on response to a collaborative-care intervention for late-life dep ... Full text Link to item Cite

Improving depression outcomes in older adults with comorbid medical illness.

Journal article Gen Hosp Psychiatry · 2005 BACKGROUND: Depression is common in older adults and often coexists with multiple chronic diseases, which may complicate its diagnosis and treatment. OBJECTIVE: To determine whether or not the presence of multiple comorbid medical illnesses affects patient ... Full text Link to item Cite

Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group

Journal article BMC health services research · December 22, 2004 BACKGROUND: A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and comm ... Cite

Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group.

Journal article BMC Health Serv Res · December 22, 2004 BACKGROUND: A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and comm ... Full text Link to item Cite

Rapid responses from bmj.com

Journal article BMJ · December 11, 2004 Full text Cite

Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection.

Journal article Bone Marrow Transplant · December 2004 Ganciclovir-resistant cytomegalovirus (CMV) infection is an emerging problem in transplant recipients. Foscarnet resistance and cidofovir resistance have also been described, but no previous reports have suggested treatment regimens for patients with CMV r ... Full text Link to item Cite

Common comorbidity scales were similar in their ability to predict health care costs and mortality.

Journal article J Clin Epidemiol · October 2004 OBJECTIVE: To compare the ability of commonly used measures of medical comorbidity (ambulatory care groups [ACGs], Charlson comorbidity index, chronic disease score, number of prescribed medications, and number of chronic diseases) to predict mortality and ... Full text Link to item Cite

Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trial.

Journal article BMJ · September 11, 2004 OBJECTIVE: To test the effectiveness of an evidence based model for management of depression in primary care with support from quality improvement resources. DESIGN: Cluster randomised controlled trial. SETTING: Five healthcare organisations in the United ... Full text Link to item Cite

A double-blind placebo-controlled pilot study of risperidone for decreasing cue-elicited craving in recently withdrawn cocaine dependent patients.

Journal article J Subst Abuse Treat · July 2004 Cocaine use causes an initial increase in dopamine and serotonin neurotransmission that is largely responsible for the pleasurable and reinforcing effects of the drug. Dysregulation of these neurotransmitters during withdrawal plays an important role in cr ... Full text Link to item Cite

Grading quality of evidence and strength of recommendations.

Journal article BMJ · June 19, 2004 Users of clinical practice guidelines and other recommendations need to know how much confidence they can place in the recommendations. Systematic and explicit methods of making judgments can reduce errors and improve communication. We have developed a sys ... Full text Link to item Cite

The effectiveness of depression care management on diabetes-related outcomes in older patients.

Journal article Ann Intern Med · June 15, 2004 Featured Publication BACKGROUND: Depression frequently occurs in combination with diabetes mellitus, adversely affecting the course of illness. OBJECTIVE: To determine whether enhancing care for depression improves affective and diabetic outcomes in older adults with diabetes ... Full text Link to item Cite

MODERN ANALOGS IN QUATERNARY PALEOECOLOGY: Here Today, Gone Yesterday, Gone Tomorrow?

Journal article Annual Review of Earth and Planetary Sciences · May 19, 2004 ▪ Abstract  Modern analog analysis, the comparison of Quaternary fossil pollen assemblages with modern assemblages, has long been a mainstay of paleoecological and paleoclimatic inference. The logic of analogical inference involves a comparative el ... Full text Cite

The door handle sign

Journal article BMJ · May 15, 2004 Full text Cite

Assessment and management of depression in older adults

Journal article Primary Psychiatry · May 1, 2004 Approximately 5% to 10% of older patients who visit a primary care provider suffer from clinically significant depression. Making the diagnosis in the older population can be challenging, as the cardinal symptom of depression, depressed mood, is less promi ... Cite

Re-engineering systems for the primary care treatment of depression.

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2004 Link to item Cite

Collaborative care for late-life depression

Conference PSYCHOSOMATICS · March 1, 2004 Link to item Cite

LATE‐QUATERNARY VEGETATION DYNAMICS IN NORTH AMERICA: SCALING FROM TAXA TO BIOMES

Journal article Ecological Monographs · February 2004 This paper integrates recent efforts to map the distribution of biomes for the late Quaternary with the detailed evidence that plant species have responded individualistically to climate change at millennial timescales. Using a fossil‐pollen data s ... Full text Cite

Treatment of recurrent hepatitis C infection after liver transplantation with combination of pegylated interferon alpha2b and ribavirin: an open-label series.

Journal article Transplantation · January 27, 2004 BACKGROUND: Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) is universal. We aimed to evaluate the efficacy and safety of pegylated interferon (PEG-IFN) and ribavirin (RIB) in the treatment of post-OLT HCV recurrence. METHOD ... Full text Link to item Cite

Low yield of thyroid-stimulating hormone testing in elderly patients with depression.

Journal article Gen Hosp Psychiatry · 2004 Although hypothyroidism is purportedly an important cause of depression, prior studies have involved small samples of young people and produced conflicting results. We examined the yield of thyroid-stimulating hormone (TSH) testing in a large group of elde ... Full text Link to item Cite

The 13- and 20-item Hopkins Symptom Checklist Depression Scale: psychometric properties in primary care patients with minor depression or dysthymia.

Journal article Int J Psychiatry Med · 2004 OBJECTIVE: Depression scales that are responsive to changes in clinical symptoms are important for clinical monitoring and outcomes assessment in longitudinal studies. We evaluated the psychometric properties and responsiveness to clinical change of the 13 ... Full text Link to item Cite

Depression and comorbid illness in elderly primary care patients: impact on multiple domains of health status and well-being.

Journal article Ann Fam Med · 2004 PURPOSE: Our objective was to examine the relative association of depression severity and chronicity, other comorbid psychiatric conditions, and coexisting medical illnesses with multiple domains of health status among primary care patients with clinical d ... Full text Link to item Cite

Going to scale: re-engineering systems for primary care treatment of depression.

Journal article Ann Fam Med · 2004 Featured Publication BACKGROUND: Recent trials have shown improved depression outcomes with chronic care models. We report the methods of a project that assesses the sustainability and transportability of a chronic care model for depression and change strategy. METHODS: In a r ... Full text Link to item Cite

Hispanic ethnicity, language, and depression: physician-patient communication and patient use of alternative treatments.

Journal article Int J Psychiatry Med · 2004 OBJECTIVE: To examine the relationship between Hispanic ethnicity and language spoken with physician communication about depression and patient use of alternative treatments for depression. METHOD: This is a secondary data analysis from a trial of depressi ... Full text Link to item Cite

Preventing suicide in primary care patients: the primary care physician's role.

Journal article Gen Hosp Psychiatry · 2004 Suicide is a critical public health problem that primary care physicians potentially can help address given that distressed patients frequently visit them in the weeks and months preceding the successful suicide. This article considers factors placing the ... Full text Link to item Cite

Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial.

Journal article JAMA · November 12, 2003 CONTEXT: Depression and arthritis are disabling and common health problems in late life. Depression is also a risk factor for poor health outcomes among arthritis patients. OBJECTIVE: To determine whether enhancing care for depression improves pain and fun ... Full text Link to item Cite

Injury in junior Australian Rules footballers.

Journal article J Sci Med Sport · September 2003 This paper reports on injuries sustained by Australian Rules footballers aged seven to 17 years, who played a full season of junior South Australia National Football League (SANFL) affiliated school or club competition in 2000. 697 boys provided informatio ... Full text Link to item Cite

Dissemination to community-based practices

Conference Journal of Psychosomatic Research · August 2003 Full text Cite

A statistical approach to evaluating distance metrics and analog assignments for pollen records

Journal article Quaternary Research · July 2003 AbstractThe modern analog technique typically uses a distance metric to determine the dissimilarity between fossil and modern biological assemblages. Despite this quantitative approach, interpretation of distance metrics is ... Full text Cite

Depression care attitudes and practices of newer obstetrician-gynecologists: a national survey.

Journal article Am J Obstet Gynecol · July 2003 OBJECTIVE: The study was undertaken to assess attitudes and behavior of newer obstetricians/gynecologists in depression care. STUDY DESIGN: One thousand randomly selected physicians in their final year of training or recent practice received a survey about ... Full text Link to item Cite

Palynological and AVHRR observations of modern vegetational gradients in eastern North America

Journal article The Holocene · May 2003 Both fossil pollen records and satellite-based instruments are remote sensors of Earth's vegetation with complementary properties. Satellites supply spatially continuous and highly resolved images for the past several decades, whereas pollen recor ... Full text Cite

Depression treatment in a sample of 1,801 depressed older adults in primary care.

Journal article J Am Geriatr Soc · April 2003 OBJECTIVES: To examine rates and predictors of lifetime and recent depression treatment in a sample of 1,801 depressed older primary care patients DESIGN: Cross sectional survey data collected from 1999 to 2001 as part of a treatment effectiveness trial. S ... Full text Link to item Cite

Antidepressant therapy in primary care: Does patient preference affect response?

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2003 Link to item Cite

Helping journalists get it right: a physicians's guide to improving health care reporting.

Journal article J Gen Intern Med · February 2003 Featured Publication News reports are the way that most people, including many physicians and scientists, first learn about new developments in medicine. Because these reports can raise awareness, influence behavior, and confer credibility, physicians should share responsibili ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal article Cochrane database of systematic reviews (Online) · 2003 BACKGROUND: For adults seeking care in ambulatory medical practices, sinusitis is the most common diagnosis treated with antibiotics. OBJECTIVES: We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are mos ... Cite

Variations in tree cover in North America since the last glacial maximum

Journal article Global and Planetary Change · January 2003 Full text Cite

Clinical findings and risk factors for Candida esophagitis in outpatients.

Journal article Dis Esophagus · 2003 We retrospectively reviewed 18 patients with endoscopically discovered Candida esophagitis to more fully characterize this entity and identify predisposing conditions. Candida esophagitis was defined by the presence of fungal mycelia on brush cytology. Onl ... Full text Link to item Cite

Lichen planus esophagitis: report of three patients treated with oral tacrolimus or intraesophageal corticosteroid injections or both.

Journal article Dis Esophagus · 2003 Clinically significant involvement of the esophagus is uncommon in patients who have lichen planus, a common disorder of squamous epithelium. In three patients who had oral, cutaneous, and esophageal lichen planus, endoscopic intralesional esophageal injec ... Full text Link to item Cite

Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression.

Journal article J Am Board Fam Pract · 2003 BACKGROUND: Dysthymia and minor depression are common problems in primary care, but it is not known how patient health beliefs shape response to antidepressant treatment of these less severe forms of depression. METHODS: Three hundred thirty-three primary ... Full text Link to item Cite

Management of allergic rhinitis in the working-age population.

Journal article Evid Rep Technol Assess (Summ) · January 2003 Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal article Cochrane Database Syst Rev · 2003 Featured Publication BACKGROUND: For adults seeking care in ambulatory medical practices, sinusitis is the most common diagnosis treated with antibiotics. OBJECTIVES: We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are mos ... Full text Link to item Cite

Impacting late life depression: integrating a depression intervention into primary care.

Journal article Psychiatr Q · 2003 groups and semi-structured individual interviews with all Depression Clinical Specialists (DCSs) working with Project IMPACT (Improving Mood: Promoting Access to Collaborative Treatment), a study testing a collaborative care intervention for late life depr ... Full text Link to item Cite

Antibiotic Treatment for Acute Maxillary Sinusitis

Journal article Annals of Emergency Medicine · January 1, 2003 Full text Cite

Cognitive disparity in schizophrenics with and without cocaine dependency.

Journal article J Subst Abuse Treat · January 2003 Although cognition has been investigated in individuals with schizophrenia and in non-schizophrenic cocaine abusers, few studies have focused on cocaine-abusing schizophrenics. Previous studies have shown contradictory results despite the fact that individ ... Full text Link to item Cite

Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial.

Journal article JAMA · December 11, 2002 CONTEXT: Few depressed older adults receive effective treatment in primary care settings. OBJECTIVE: To determine the effectiveness of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) collaborative care management program for late-li ... Full text Link to item Cite

An analysis of cue reactivity among persons with and without schizophrenia who are addicted to cocaine.

Journal article Psychiatr Serv · December 2002 OBJECTIVE: Persons with schizophrenia who are addicted to cocaine experience more psychiatric and substance abuse relapses and worse long-term outcomes than persons with only one of these conditions. This study examined whether individuals with cocaine dep ... Full text Link to item Cite

How a rare diagnosis caused me to sprain my ankle

Journal article BMJ · November 2, 2002 Full text Cite

The relation between methods and recommendations in clinical practice guidelines for hypertension and hyperlipidemia.

Journal article J Fam Pract · November 2002 OBJECTIVE: To assess the association between methods used to develop clinical practice guidelines and the recommendations that are made. STUDY DESIGN: Systematic review of clinical practice guidelines for hypertension or hyperlipidemia. OUTCOMES MEASURED: ... Link to item Cite

Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence.

Journal article Can J Psychiatry · September 2002 OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence. METHOD: We conducted a 6-week, open-label pilot stu ... Full text Link to item Cite

Improving care for late life depression.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2002 Link to item Cite

Low yield of TSH testing in elderly patients with depression.

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2002 Link to item Cite

Rational treatment choices for non-major depressions in primary care: an evidence-based review.

Journal article J Gen Intern Med · April 2002 OBJECTIVE: This review synthesizes available evidence for managing clinically significant dysphoric symptoms encountered in primary care, when formal criteria for major depression or dysthymia are not met. Discussion is focused on premenstrual dysphoric di ... Full text Link to item Cite

Identifying patients with major depression in primary care.

Journal article JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2002 Link to item Cite

Efficacy of intranasal corticosteroids for acute sinusitis - Reply

Journal article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · March 13, 2002 Link to item Cite

Is this patient clinically depressed?

Journal article JAMA · March 6, 2002 Featured Publication CONTEXT: Depressive disorders are highly prevalent in the general population, but recognition and accurate diagnosis are made difficult by the lack of a simple confirmatory test. OBJECTIVE: To review the accuracy and precision of depression questionnaires ... Full text Link to item Cite

Experiences with leflunomide in solid organ transplantation.

Journal article Transplantation · February 15, 2002 BACKGROUND: Leflunomide (Arava), a drug widely used for treatment of rheumatoid arthritis, has a very promising background in experimental transplantation. Its activity in experimental models of chronic rejection, its synergy with calcineurin phosphatase i ... Full text Link to item Cite

A three-component model for reengineering systems for the treatment of depression in primary care.

Journal article Psychosomatics · 2002 Depression in primary care is a chronic disease. As with most chronic diseases, long-term adherence to treatment plans is problematic. Evidence-based systems of care address this problem, but persistence and dissemination of systems after testing is a new ... Full text Link to item Cite

Correlates of remission in primary care patients treated for minor depression.

Journal article Gen Hosp Psychiatry · 2002 As minor depression is perhaps the most common form of mood disorder seen in primary care, we sought to explore the effects of both pharmacologic and psychosocial interventions for primary care patients with this condition. Three hundred and eighteen prima ... Full text Link to item Cite

Identifying depression in primary care: a literature synthesis of case-finding instruments.

Journal article Gen Hosp Psychiatry · 2002 We evaluated the usefulness of case-finding instruments for identifying patients with major depression or dysthymia in primary care settings using English language literature from Medline, a specialized trials registry and bibliographies of selected papers ... Full text Link to item Cite

Predictors of nonresponse to treatment in primary care patients with dysthymia.

Journal article Gen Hosp Psychiatry · 2002 Dysthymia is one of the most prevalent problems in primary care, especially in the elderly. In this study, we evaluated the demographic and clinical predictors of nonresponse to treatment in primary care patients with dysthymia. The study sample consisted ... Full text Link to item Cite

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.

Other Anesth Analg · January 2002 UNLABELLED: Neurocognitive dysfunction is a common complication after cardiac surgery. We evaluated in this prospective study the effect of rewarming rate on neurocognitive outcome after hypothermic cardiopulmonary bypass (CPB). After IRB approval and info ... Full text Link to item Cite

Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial.

Journal article JAMA · December 26, 2001 CONTEXT: It is not known whether intranasal corticosteroids are beneficial to treat acute rhinosinusitis in patients with a history of chronic or recurrent sinus symptoms. OBJECTIVE: To assess whether the addition of an intranasal corticosteroid to antibio ... Full text Link to item Cite

Treatment of depression.

Journal article J Fam Pract · December 2001 Link to item Cite

Strategies for diagnosing and treating suspected acute bacterial sinusitis: a cost-effectiveness analysis.

Journal article J Gen Intern Med · October 2001 OBJECTIVE: Symptoms suggestive of acute bacterial sinusitis are common. Available diagnostic and treatment options generate substantial costs with uncertain benefits. We assessed the cost-effectiveness of alternative management strategies to identify the o ... Full text Link to item Cite

Identifying physicians likely to benefit from depression education: a challenge for health care organizations.

Journal article Med Care · August 2001 BACKGROUND: Few methods exist to identify physicians who might benefit from depression education. OBJECTIVES: To develop a measure of physicians' confidence or self-efficacy in caring for depressed patients and assess it's reliability and validity. RESEARC ... Full text Link to item Cite

Improving primary care for depression in late life: the design of a multicenter randomized trial.

Journal article Med Care · August 2001 BACKGROUND: Late life depression can be successfully treated with antidepressant medications or psychotherapy, but few depressed older adults receive effective treatment. RESEARCH DESIGN: A randomized controlled trial of a disease management program for la ... Full text Link to item Cite

Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection.

Journal article Transplantation · June 15, 2001 BACKGROUND: T-cell activation and the subsequent induction of effector functions require not only the recognition of antigen peptides bound to MHC molecules by T-cell receptor (TCR) for antigen but also a costimulatory signal provided by antigen presenting ... Full text Link to item Cite

Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection.

Journal article Transplantation · May 27, 2001 BACKGROUND: The objective of this study was to evaluate the role of anti-Gal Abs and non-anti-Gal Abs in hyperacute rejection (HAR) of concordant pancreas xenografts compared with heart xenografts. In addition, we tested whether rejection of Lewis rat panc ... Full text Link to item Cite

Treatment of dysthymia and minor depression in primary care: a randomized trial in patients aged 18 to 59 years.

Journal article J Fam Pract · May 2001 OBJECTIVE: The researchers evaluated the effectiveness of paroxetine and Problem-Solving Treatment for Primary Care (PST-PC) for patients with minor depression or dysthymia. STUDY DESIGN: This was an 11-week randomized placebo-controlled trial conducted in ... Link to item Cite

Journals of the Century in Social Work

Journal article The Serials Librarian · March 19, 2001 Full text Cite

Seventh Day Syndrome--acute hepatocyte apoptosis associated with a unique syndrome of graft loss following liver transplantation.

Conference Liver · February 2001 AIM: The aim of this study is to describe a unique 7th day syndrome (7DS), quite different from other causes of post-transplantation allograft dysfunction in a group of orthotopic liver transplant (OLT) patients who needed retransplantation. METHODS: A ret ... Full text Link to item Cite

Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide.

Journal article Transplantation · January 15, 2001 BACKGROUND: Despite advances in antiviral chemotherapy, herpes simplex virus type 1 (HSV-1), continues to complicate the clinical course of many allograft recipients. We have previously demonstrated that the experimental immunosuppressive agent leflunomide ... Full text Link to item Cite

Status of minor depression or dysthymia in primary care following a randomized controlled treatment.

Journal article Gen Hosp Psychiatry · 2001 This report describes the rates of recovery and remission from minor depression or dysthymia in primary care patients three months after completing a randomized controlled treatment trial. The subjects were primary care patients who received > or =4 treatm ... Full text Link to item Cite

Treatment of depression [2] multiple letters

Journal article Journal of Family Practice · January 1, 2001 Cite

Efficacy of newer medications for treating depression in primary care patients

Journal article British Journal of Clinical Governance · January 1, 2001 Cite

Treatment of mild depression in elderly patients - Reply

Journal article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · December 20, 2000 Link to item Cite

Treatment of mild depression in elderly patients.

Journal article JAMA · December 20, 2000 Link to item Cite

Treatment of mild depression in elderly patients.

Journal article JAMA · December 20, 2000 Link to item Cite

Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice.

Journal article Xenotransplantation · November 2000 The anti-galactose-alpha1,3-galactose (Gal) antibody (Ab) response following pig-to-human transplantation is vigorous and largely resistant to currently available immunosuppression. The recent generation of GT-Ko mice provides a unique opportunity to study ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis

Journal article Praxis · September 28, 2000 Cite

Treatment of dysthymia and minor depression in primary care: A randomized controlled trial in older adults.

Journal article JAMA · September 27, 2000 Featured Publication CONTEXT: Insufficient evidence exists for recommendation of specific effective treatments for older primary care patients with minor depression or dysthymia. OBJECTIVE: To compare the effectiveness of pharmacotherapy and psychotherapy in primary care setti ... Full text Link to item Cite

Users' guides to the medical literature: XXIV. How to use an article on the clinical manifestations of disease. Evidence-Based Medicine Working Group.

Journal article JAMA · August 16, 2000 Clinicians rely on knowledge about the clinical manifestations of disease to make clinical diagnoses. Before using research on the frequency of clinical features found in patients with a disease, clinicians should appraise the evidence for its validity, re ... Full text Link to item Cite

Erratum

Journal article Quaternary Research · July 2000 Full text Cite

Anti-galactose-alpha(1,3) galactose antibody production in alpha1,3-galactosyltransferase gene knockout mice after xeno and allo transplantation.

Journal article Transpl Immunol · June 2000 Antibodies (Abs) that mediate the hyperacute rejection and acute vascular rejection/delayed xenograft rejection of pig organs in humans and Old World primates are predominantly directed at a single carbohydrate epitope, galactose-alpha1,3-galactose (alpha1 ... Full text Link to item Cite

A systematic review of newer pharmacotherapies for depression in adults: evidence report summary.

Journal article Ann Intern Med · May 2, 2000 BACKGROUND: Depressive disorders are persistent, recurring illnesses that cause great suffering for patients and their families. PURPOSE: To evaluate the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders ... Full text Link to item Cite

Late Quaternary biomes of Canada and the eastern United States

Journal article Journal of Biogeography · May 2000 AbstractPollen data have been used to construct biome maps for today, 6000 14C yr bpand 18,000 14C yr bpfor Canada and the eastern United State ... Full text Cite

Pollen‐based biomes for Beringia 18,000, 6000 and 0 14C yr †

Journal article Journal of Biogeography · May 2000 AbstractThe objective biomization method developed by Prentice et al. (1996) for Europe was extende ... Full text Cite

Tolerance of T-independent xeno-antibody responses in the hamster-to-rat xenotransplantation model is species-restricted but not tissue-specific.

Journal article Xenotransplantation · February 2000 Control of early acute xenograft rejection xenoreactions in the hamster-to-Lewis rat xenotransplantation model with cyclosporine (CsA) and leflunomide subdues early T-independent xenoreactivity and uncovers a late immune response that can be controlled by ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal article Cochrane database of systematic reviews (Online) · 2000 OBJECTIVES: For adults seeking care in ambulatory practices, sinusitis is the most common diagnosis treated with antibiotics. We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are most effective. SEARCH ... Cite

The jejunal pouch as a rectal substitute after proctocolectomy.

Journal article J Gastrointest Surg · 2000 Our hypothesis was that a jejunal pouch used as a rectal substitute after proctocolectomy would slow enteric transit, delay defecation, and decrease stool frequency compared to an ileal pouch so used. Twelve dogs underwent proctocolectomy; six had a jejuna ... Full text Link to item Cite

Approach to depressive disorders - Reply

Journal article ARCHIVES OF FAMILY MEDICINE · January 2000 Link to item Cite

Referrals to psychiatrists. Assessing the communication interface between psychiatry and primary care.

Journal article Psychosomatics · 2000 The Study of Outpatient Referral Patterns was conducted in 1998 to examine the nature of the communication relationship between psychiatrists and primary care physicians regarding outpatient referrals. Nationally representative psychiatrists were surveyed ... Full text Link to item Cite

The relationship of aging and dysthymia in primary care.

Journal article Am J Geriatr Psychiatry · 2000 The authors compared symptomatic and functional characteristics between older (age > or =60; n=91) and younger (age 18-59; n=125) primary care patients with dysthymia. Three of six significantly different depression symptoms were of moderate-to-large effec ... Link to item Cite

Efficacy of newer medications for treating depression in primary care patients.

Journal article Am J Med · January 2000 PURPOSE: Several medications have recently been introduced for the treatment of depression. We reviewed the literature to summarize their efficacy in the treatment of depression in adult patients in primary care settings. METHODS: We searched the literatur ... Full text Link to item Cite

Health promotion research with mexican american elders: Matching approaches to settings at the mediator- and micro-levels of recruitment

Journal article Journal of Mental Health and Aging · January 1, 2000 Minority elders are inadequately represented in health promotion research. A contributing factor may be that recruitment approaches have not been well adapted to the life experiences of these populations. This article examines recruitment approaches used i ... Cite

Transcriptional regulation of Fas gene expression by GA-binding protein and AP-1 in T cell antigen receptor.CD3 complex-stimulated T cells.

Journal article J Biol Chem · December 3, 1999 Fas (CD95 or APO-1), a transmembrane cell surface receptor of the tumor necrosis factor receptor family, is up-regulated in activated T lymphocytes. Our present study identified an upstream enhancer element (between nucleotide positions -862 and -682) cont ... Full text Link to item Cite

In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action.

Journal article Biochem Pharmacol · November 1, 1999 Leflunomide, a novel immunomodulatory drug, has two biochemical activities: inhibition of tyrosine phosphorylation and inhibition of pyrimidine nucleotide synthesis. In the present study, we first showed that A77 1726 [N-(4-trifluoromethylphenyl-2-cyano-3- ... Full text Link to item Cite

The portosystemic shunt protects liver against ischemic reperfusion injury.

Journal article Transplantation · October 15, 1999 BACKGROUND: The goal of this study was to characterize the importance of splanchnic viscera in liver ischemic reperfusion injury and to enhance the tolerance of liver to warm ischemia injury with portosystemic shunt. METHODS: The hepatic blood flow of male ... Full text Link to item Cite

Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide.

Conference Transplantation · September 27, 1999 BACKGROUND: Despite progress in antiviral chemotherapy, cytomegalovirus (CMV) remains a major cause of morbidity and mortality among pharmacologically immunosuppressed organ transplant recipients, frequently engaging the clinician in a struggle to balance ... Full text Link to item Cite

Treatment of depression--newer pharmacotherapies.

Journal article Evid Rep Technol Assess (Summ) · March 1999 Link to item Cite

Extracorporeal liver perfusion.

Journal article Lancet · January 9, 1999 Full text Link to item Cite

Characterizing the referral interface between psychiatry and primary care

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1999 Link to item Cite

Efficient gene transfer and expression in islets by an adenoviral vector that lacks all viral genes.

Journal article Cell Transplant · 1999 Although adenoviral vector-mediated gene transfer has significant potential for gene therapy, host immune responses to virally expressed proteins and small insert capacity may limit its clinical application. In order to overcome these disadvantages, a new ... Full text Link to item Cite

Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide.

Conference Intervirology · 1999 Despite progress in antiviral chemotherapy, cytomegalovirus (CMV) remains a major cause of morbidity and mortality among pharmacologically immunosuppressed transplant recipients, frequently engaging the clinician in a struggle to balance graft preservation ... Full text Link to item Cite

The treatment effectiveness project. A comparison of the effectiveness of paroxetine, problem-solving therapy, and placebo in the treatment of minor depression and dysthymia in primary care patients: background and research plan.

Journal article Gen Hosp Psychiatry · 1999 This report describes the background, rationale, and research plan for a comparative treatment trial of the effectiveness of paroxetine, problem-solving therapy (PST-PC), and placebo in the treatment of minor depression and dysthymia in primary care patien ... Full text Link to item Cite

Primary care physicians' approach to depressive disorders. Effects of physician specialty and practice structure.

Journal article Arch Fam Med · 1999 BACKGROUND: Because primary care physicians (PCPs) are the initial health care contact for most patients with depression, they are in a unique position to provide early detection and integrated care for persons with depression and coexisting medical illnes ... Full text Link to item Cite

Case-finding for depression in primary care: a randomized trial.

Journal article Am J Med · January 1999 PURPOSE: Depression is a highly prevalent, morbid, and costly illness that is often unrecognized and inadequately treated. Because depression questionnaires have the potential to improve recognition, we evaluated the accuracy and effects on primary care of ... Full text Link to item Cite

The best evidence from ACP Journal Club for general internal medicine, 1999.

Journal article ACP Journal Club · January 1, 1999 Cite

Evidence report on: Treatment of depression - Newer pharmacotherapies

Journal article Psychopharmacology Bulletin · December 1, 1998 Objectives: Depressive disorders are persistent, recurring illnesses that impose enormous personal suffering on individuals and their families. Major depression alone is estimated as the fourth most important cause of worldwide loss in disability-adjusted ... Cite

FK506 treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation.

Journal article Transplantation · October 15, 1998 BACKGROUND: In the experiment described here, we investigated the effects of the immunosuppressants FK506 and leflunomide (Lef) on the survival of hamster hearts and liver xenografts in Lewis rats. METHODS: Lewis rats were used as recipients of hamster hea ... Full text Link to item Cite

Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation.

Journal article Transplantation · September 27, 1998 BACKGROUND: Chronic allograft rejection remains a major barrier to successful long-term allograft transplantation in humans. Chronic allograft rejection is characterized by the appearance of arterial lesions with concentric intimal thickening. This study i ... Full text Link to item Cite

Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model.

Journal article J Immunol · August 15, 1998 The combination of two immunosuppressants, leflunomide and cyclosporin A (CsA), completely inhibits immune xenoreactions in the hamster-to-Lewis rat xenotransplantation model. In addition, the control of acute xenograft rejection with this combination of i ... Link to item Cite

Targeting depression interviewing.

Journal article J Gen Intern Med · August 1998 Full text Link to item Cite

Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats.

Journal article Transplantation · July 27, 1998 BACKGROUND: Ischemic-preconditioning is a process whereby a brief ischemic episode confers a state of protection against subsequent long-term ischemia-reperfusion injury. Ischemic preconditioning has been studied in heart and liver ischemia-reperfusion inj ... Full text Link to item Cite

Anti-CD4 therapy in combined heart-kidney, heart-liver, and heart-small bowel allotransplants in high-responder rats.

Journal article Transplantation · July 15, 1998 BACKGROUND: In these experiments, we studied the role of anti-CD4 (Ox38) monoclonal antibody in the induction of allograft unresponsiveness in high-responder Lewis rats in the single liver, kidney, small bowel, and heart versus the combined heart-kidney, h ... Full text Link to item Cite

Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice.

Journal article Transplantation · May 27, 1998 BACKGROUND: We and others have reported previously that the immunosuppressant, leflunomide (Lef), can prevent allogeneic and xenogeneic islet graft rejection in streptozocin (STZ)-induced diabetic animals. However, whether Lef required to prevent islet gra ... Full text Link to item Cite

Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production.

Journal article J Immunol · February 15, 1998 Leflunomide is an immunosuppressive drug capable of inhibiting T and B cell responses in vivo. A number of studies demonstrate that leflunomide functions both as a pyrimidine synthesis inhibitor and as a tyrosine kinase inhibitor. We previously reported th ... Link to item Cite

In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium.

Journal article J Immunol · January 15, 1998 Intracellular pyrimidine nucleotides (PyN) can be synthesized de novo from glutamine, CO2, and ATP, or they can be salvaged from preformed pyrimidine nucleosides. The antiproliferative and immunosuppressive activities of brequinar sodium (BQR) are thought ... Link to item Cite

Identifying physicians most likely to benefit from depression education

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1998 Link to item Cite

Newer pharmacotherapies for depression in primary care: A literature synthesis

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1998 Link to item Cite

Assessing the referral interface and communication between psychiatry and primary care

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1998 Link to item Cite

The course of depression in primary care.

Conference JOURNAL OF INVESTIGATIVE MEDICINE · January 1, 1998 Link to item Cite

Meeting the needs of primary care physicians: a guide to content for programs on depression.

Journal article Int J Psychiatry Med · 1998 OBJECTIVE: The purpose of this article is to identify literature-based content for the design of educational programs on depression for practicing primary care physicians. METHODS: A MEDLINE search was conducted of English-language medical literature publi ... Full text Link to item Cite

Treatment of depression--newer pharmacotherapies.

Journal article Psychopharmacol Bull · 1998 OBJECTIVES: Depressive disorders are persistent, recurring illnesses that impose enormous personal suffering on individuals and their families. Major depression alone is estimated as the fourth most important cause of worldwide loss in disability-adjusted ... Link to item Cite

Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts.

Conference Transplantation · December 27, 1997 BACKGROUND: Vigorous antibody-mediated responses prevent the successful engraftment of hamster hearts transplanted into Lewis rats. Early antibody responses mediating acute rejection of the xenograft are T cell-independent and resistant to the T-cell immun ... Full text Link to item Cite

Serials Cataloging, 1991-1996

Journal article The Serials Librarian · November 3, 1997 Full text Cite

Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action.

Journal article J Pharmacol Exp Ther · November 1997 Brequinar sodium (BQR) was originally developed as an antitumor drug and subsequently as an immunosuppressant for controlling transplant rejection. It has been widely accepted that the antitumor and immunosuppressive activities of BQR are dependent on its ... Link to item Cite

Quantitation of the changes in splenic architecture during the rejection of cardiac allografts or xenografts.

Journal article Transplantation · August 15, 1997 BACKGROUND: The spleen plays a central role in the generation of both cellular and antibody responses during graft rejection. Although changes in lymphocyte function have been extensively analyzed in vitro, there have been limited attempts at quantitating ... Full text Link to item Cite

Effect of anti-CD4 monoclonal antibody combined with human CTLA4Ig on the survival of hamster liver and heart xenografts in Lewis rats.

Journal article Transplantation · July 27, 1997 We investigated the effects of pretransplant anti-CD4 monoclonal antibody (mAb) combined with human (h) CTLA4Ig on the survival of hamster heart and liver xenografts. Pretransplant anti-CD4 mAb (5 mg/kg x 4 days) or hCTLA4Ig (0.5 mg/rat on days 1, 3, and 5 ... Full text Link to item Cite

The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms.

Journal article J Immunol · July 1, 1997 The immunosuppressive metabolite of leflunomide, A77 1726, inhibits the enzymatic activity of protein tyrosine kinases and of dihydro-orotic acid dehydrogenase, an enzyme involved in pyrimidine biosynthesis. Here murine CTLL cell lines were studied to dete ... Link to item Cite

In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.

Journal article J Immunol · July 1, 1997 Two activities have been identified for the immunosuppressive metabolite of leflunomide, A77 1726: inhibition of dihydroorotate dehydrogenase (DHO-DHase), an enzyme involved in the biosynthesis of pyrimidine nucleotides (PyN); and inhibition of protein tyr ... Link to item Cite

Prediction of abstinence from ethanol in alcoholic recipients following liver transplantation.

Journal article Hepatology · June 1997 The prediction of abstinence from ethanol may be crucial to the optimal selection of liver transplantation candidates with alcoholism. Of 84 consecutive end-stage alcoholic patients who underwent transplantation (1986-1994) at our institution, we analyzed ... Full text Link to item Cite

In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function.

Journal article Transplantation · March 15, 1997 Leflunomide (Lef) is a novel immunosuppressant that can prevent islet allograft and xenograft rejection. In this study, we investigated the in vivo effects of Lef on the function of normal pancreatic islets and syngeneic islet grafts in rats and compared i ... Full text Link to item Cite

Prolongation of rat islet allograft survival by the immunosuppressive agent leflunomide.

Journal article Transplantation · March 15, 1997 The purpose of this study was to investigate the effect of Leflunomide (Lef), alone or in combination with a suboptimal dose of cyclosporine (CsA), on rat allogeneic islet transplantation. Two thousands islets were transplanted under the left kidney capsul ... Full text Link to item Cite

A practical guide for the diagnosis and treatment of acute sinusitis.

Journal article CMAJ · March 15, 1997 OBJECTIVE: To develop guidelines for the diagnosis and management of acute sinusitis. OPTIONS: Diagnostic clinical criteria and imaging techniques, the role of antimicrobial therapy and duration of treatment, and the role of adjunct therapy, including deco ... Link to item Cite

Banff schema for grading liver allograft rejection: an international consensus document.

Journal article Hepatology · March 1997 A panel of recognized experts in liver transplantation pathology, hepatology, and surgery was convened for the purpose of developing a consensus document for the grading of acute liver allograft rejection that is scientifically correct, simple, and reprodu ... Full text Link to item Cite

Knowledge and attitudes about depression among non-generalists and generalists.

Journal article J Fam Pract · February 1997 BACKGROUND: The purpose of this study was to learn more about barriers to managing depression by comparing knowledge and attitudes about depression among physicians, internists, obstetrician-gynecologists, and a reference group of psychiatrists. Among the ... Link to item Cite

Reduced blue cone electroretinogram in cocaine-withdrawn patients.

Journal article Arch Gen Psychiatry · February 1997 BACKGROUND: The main reinforcing effect of cocaine is alteration of dopaminergic neurotransmission in the brain reward systems. Since dopamine is found in high concentrations in the retina, we investigated whether cocaine dependence may be associated with ... Full text Link to item Cite

The relationship of age to dysthymia in primary care

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1997 Link to item Cite

A practical guide for the diagnosis and treatment of acute sinusitis

Journal article CANADIAN MEDICAL ASSOCIATION JOURNAL · January 1, 1997 Link to item Cite

General internists influence students to choose primary care careers: the power of role modeling.

Journal article Am J Med · December 1996 PURPOSE: To determine whether medical students supervised by general internist attendings during the third-year medicine clerkship are more likely to choose primary care careers than students supervised by subspecialist attendings. METHODS: One hundred for ... Full text Link to item Cite

Renal transplantation without sutures using the vascular clipping system for renal artery and vein anastomosis--a new technique.

Journal article Transplantation · October 27, 1996 A cadaveric renal transplant was performed on a 63-year-old woman. The donor renal artery and vein were anastomosed to the recipient external iliac vessels using the vascular clipping system. These vascular anastomoses were performed with four stay sutures ... Full text Link to item Cite

Introduction

Journal article The Serials Librarian · July 1996 Full text Cite

Granulocyte colony-stimulating factor immunomodulation in the rat cardiac transplantation model.

Journal article Transplantation · April 15, 1996 Granulocyte colony-stimulating factor (G-CSF) administration decreases tumor necrosis factor(TNF) release, an important mechanism in allograft rejection. to study G-CSF's possible antirejection effects, 30 Lewis rats underwent heart transplantation using B ... Full text Link to item Cite

Regulation of B cell function by the immunosuppressive agent leflunomide.

Journal article Transplantation · February 27, 1996 Leflunomide is an immunosuppressive drug capable of inhibiting cellular and humoral mediated responses in vivo. The mechanism responsible for suppression of B cell antibody responses in vivo has not been identified. In this study we demonstrate that leflun ... Full text Link to item Cite

Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro.

Journal article Transplantation · January 15, 1996 Leflunomide and its active metabolite, A771726, are structurally unrelated to immunosuppressive agents currently under investigation. Previous in vitro studies have revealed that leflunomide primarily inhibits interleukin-2-stimulated T cell proliferation. ... Full text Link to item Cite

Ultraviolet-B irradiation of leukapheresis. Products: dose-response relationship with the mixed lymphocyte reaction.

Journal article J Clin Apher · 1996 Ultraviolet-B (UVB) irradiation of blood constituents intensifies their anti-rejection effect in pretransplant donor-specific transfusions. UVB-induced inhibition of the mixed lymphocyte reaction (MLR) between UVB-irradiated donor cells and prospective rec ... Full text Link to item Cite

Siloxane polymers with pendant metal carbonyl groups

Conference METAL-CONTAINING POLYMERIC MATERIALS · 1996 Link to item Cite

BECK DEPRESSION INVENTORY (VOL 122, PG 913, 1995)

Journal article ANNALS OF INTERNAL MEDICINE · December 15, 1995 Link to item Cite

Pharmacologically induced regression of chronic transplant rejection.

Journal article Transplantation · November 27, 1995 Chronic rejection, characterized by a progressive obliterative arteriopathy, is a major cause of graft failure in long-surviving human transplants for which there is no effective treatment. Leflunomide, an isoxazol derivative, has been shown to be a novel ... Full text Link to item Cite

Three vs 10 Days of Trimethoprim/Sulfamethoxazole for Acute Maxillary Sinusitis-Reply

Journal article JAMA: The Journal of the American Medical Association · November 1, 1995 Full text Cite

The use of granulocyte colony-stimulating factor after liver transplantation.

Journal article Transplantation · June 15, 1995 Granulocyte colony-stimulating factor (G-CSF) increases the number of circulating granulocytes and decreases TNF production while improving survival in sepsis models. To study the effects of G-CSF administration on sepsis and rejection, 37 primary liver al ... Link to item Cite

Case-finding instruments for depression in primary care settings.

Journal article Ann Intern Med · June 15, 1995 OBJECTIVE: To evaluate the usefulness of case-finding instruments for identifying patients with major depression in primary care settings. DATA SOURCES: A MEDLINE search of the English-language medical literature; bibliographies of selected papers; and exp ... Full text Link to item Cite

Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide.

Journal article J Biol Chem · May 26, 1995 Leflunomide, a novel immunosuppressive drug, is able to prevent and reverse allograft and xenograft rejection in rodents, dogs, and monkeys. It is also effective in the treatment of several rodent models of arthritis and autoimmune disease. In vitro studie ... Full text Link to item Cite

Users' Guides to the Medical Literature

Journal article JAMA · May 24, 1995 Full text Cite

Randomized controlled trial of 3 vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis.

Journal article JAMA · April 5, 1995 OBJECTIVE: To compare 14-day outcomes and relapse and recurrence rates among patients with acute maxillary sinusitis randomized to 3-day (3D) vs 10-day (10D) treatment with trimethoprim/sulfamethoxazole (TMP/SMX). SETTING: University-affiliated Veterans Af ... Link to item Cite

Measuring shoulder function with the Shoulder Pain and Disability Index.

Journal article J Rheumatol · April 1995 OBJECTIVE: To extend the validity of the Shoulder Pain and Disability Index (SPADI) by (1) making it suitable for telephone administration; (2) determining its convergent validity with other health status measures; and (3) assessing the responsiveness of t ... Link to item Cite

Usual care and outcomes in patients with sinus complaints and normal results of sinus roentgenography.

Journal article Arch Fam Med · March 1995 OBJECTIVE: To describe the usual care and outcomes of patients with sinus symptoms and normal sinus roentgenograms. DESIGN: Prospective cohort with 60-day follow-up. SETTING: Medical outpatient clinics at a university-affiliated Veterans Affairs medical ce ... Full text Link to item Cite

Depressive disorders in primary care: prevalence, functional disability, and identification.

Journal article J Gen Intern Med · January 1995 OBJECTIVES: To assess the relative prevalence of subsyndromal depression (SubD) and major depression (MDD) in primary care patients and describe their associated functional impairments, and to define the operating characteristics of a short depression scre ... Full text Link to item Cite

Users' Guides to the Medical Literature

Journal article JAMA · November 2, 1994 Full text Cite

Leflunomide controls rejection in hamster to rat cardiac xenografts.

Journal article Transplantation · October 15, 1994 Leflunomide is an isoxazole derivative that has the ability to prevent acute rejection of cardiac, renal, and skin transplants in strongly rejecting rat models. Furthermore, leflunomide is able to interact synergistically with CsA to inhibit allograft reje ... Link to item Cite

Performance of case-finding tools for depression in the nursing home: influence of clinical and functional characteristics and selection of optimal threshold scores.

Journal article J Am Geriatr Soc · October 1994 OBJECTIVE: To compare case-finding tools for depression in the nursing home setting and to evaluate effects of subject function, cognition, and disease number on test performance. DESIGN: Cross-sectional survey. SETTING: One academic and four community hom ... Full text Link to item Cite

SILOXANE POLYMERS WITH PENDANT METAL-CARBONYL GROUPS

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 21, 1994 Link to item Cite

Users' Guides to the Medical Literature

Journal article JAMA · July 20, 1994 Full text Cite

An evaluation of leflunomide in the canine renal transplantation model.

Journal article Transplantation · June 27, 1994 Leflunomide is an isoxazole with newly discovered immunosuppressive properties. Its mechanism of action operates later in the cell cycle than cyclosporine and appears to interfere with lymphocyte IL-2 responsiveness. With the encouraging results from in vi ... Link to item Cite

Splanchnic transplantation.

Conference Transplant Proc · June 1994 Link to item Cite

Users' Guides to the Medical Literature

Journal article JAMA · May 25, 1994 Full text Cite

Leflunomide in experimental transplantation. Control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporine.

Journal article Transplantation · April 27, 1994 Leflunomide is a compound recently shown to reduce T and B cell-mediated responses in a number of experimental rat, mouse, and human systems. To explore its potential as an immunosuppressant, we studied leflunomide in 128 Brown-Norway/Lewis cardiac transpl ... Link to item Cite

Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin's disease: association with mixed cellularity subtype and Hispanic American ethnicity.

Journal article Blood · March 15, 1994 One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected ... Link to item Cite

In Reply

Journal article JAMA the Journal of the American Medical Association · February 16, 1994 Full text Cite

DOES THIS PATIENT HAVE SINUSITIS - REPLY

Journal article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · February 16, 1994 Link to item Cite

Users' Guides to the Medical Literature

Journal article JAMA · January 5, 1994 Full text Cite

Current diagnosis and management of sinusitis.

Journal article J Gen Intern Med · January 1994 Full text Link to item Cite

Users' Guides to the Medical Literature

Journal article JAMA · December 1, 1993 Full text Cite

WANTED - SUBMISSIONS FOR THE DEFINITIVE BOOK OF MEDICAL RECORDS

Journal article ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE · November 1993 Link to item Cite

Wanted: Submissions for the Definitive Book of Medical Records

Journal article Archives of Internal Medicine · July 26, 1993 Full text Cite

Wanted: Submissions for the definitive book of medical records

Journal article The American Journal of Medicine · July 1993 Full text Cite

Diagnosing sinusitis.

Journal article Ann Intern Med · July 1, 1993 Full text Link to item Cite

Diagnosing Sinusitis

Journal article Annals of Internal Medicine · July 1, 1993 Full text Cite

Leflunomide, a novel immunosuppressive agent. The mechanism of inhibition of T cell proliferation.

Journal article Transplantation · June 1993 Leflunomide is a novel immunomodulating drug that has recently been demonstrated to prevent acute rejection and reverse ongoing rejection of kidney and cardiac allografts in rats. In vitro studies here demonstrate that leflunomide suppresses proliferation ... Full text Link to item Cite

SOCIAL NEEDS AND SUBTHRESHOLD DEPRESSION

Conference CLINICAL RESEARCH · April 1, 1993 Link to item Cite

GODFREY, ILLINOIS - ESTABLISHING A NEW CITY (A CASE-STUDY)

Conference 10TH CONFERENCE ON THE SMALL CITY AND REGIONAL COMMUNITY · 1993 Link to item Cite

Serials Cataloging, 1985- 1990

Journal article The Serials Librarian · November 9, 1992 Full text Cite

Introduction

Journal article The Serials Librarian · November 9, 1992 Full text Cite

Clinical evaluation for sinusitis. Making the diagnosis by history and physical examination.

Journal article Ann Intern Med · November 1, 1992 OBJECTIVE: To identify the most useful clinical examination findings for the diagnosis of acute and subacute sinusitis. DESIGN: Prospective comparison of clinical findings with radiographs. SETTING: General medicine clinics at a university-affiliated Veter ... Full text Link to item Cite

In Reply

Journal article JAMA the Journal of the American Medical Association · October 28, 1992 Full text Cite

Argon laser treatment of trichiasis.

Journal article Am J Ophthalmol · September 15, 1992 Full text Link to item Cite

Percutaneous interstitial laser therapy of a patient with recurrent hepatoma in a transplanted liver.

Journal article Surgery · September 1992 We report in situ treatment, by focal hyperthermia, of a recurrent hepatoma in the transplanted liver of a 53-year-old man. Hyperthermia was generated by neodymium-yttrium-aluminum-garnet laser, which was delivered through a fiber placed inside a 19-gauge ... Link to item Cite

The role of ultraviolet B-irradiated leukocyte transfusions and cyclosporine in intestinal transplantation.

Journal article Transplantation · July 1992 To explore the efficacy of ultraviolet B-irradiated donor-specific leukocyte transfusions (UV-DSLT) with short-term cyclosporine to control intestinal allograft rejection, 75 adult Lewis (RT1l) rats underwent total small-intestinal transplantation from Bro ... Full text Link to item Cite

Prospective analysis of mental status progression in ethanol-intoxicated patients.

Journal article Am J Emerg Med · July 1992 Distinguishing patients with uncomplicated ethanol intoxication from intoxicated patients with other causes of mental status depression is a common clinical dilemma. The authors serially tested mental status in a group of ethanol-intoxicated patients to de ... Full text Link to item Cite

Central venous catheterization in patients with coagulopathy.

Journal article Arch Surg · March 1992 To explore the risk of bleeding complications during percutaneous central venous catheterization in patients with coagulopathy, 40 liver transplant recipients underwent 259 percutaneous central venous catheterizations. Two hundred two catheterizations were ... Full text Link to item Cite

Role of liver allograft biopsy in patient management.

Journal article Semin Liver Dis · February 1992 Acute rejection is the end result of progressive accumulation (most prominently in portal tracts) of mononuclear cells, PMNs, and eosinophils. The anatomic location of these cells, such as outside the limiting plate, in the venous endothelium or biliary ep ... Full text Link to item Cite

Diagnosing sinusitis by X-ray: is a single Waters view adequate?

Journal article J Gen Intern Med · 1992 OBJECTIVE: To determine whether a single Waters view (occipito-mental) radiograph could be substituted for a four-view sinus series to diagnose sinusitis, and to determine the inter- and intraobserver variabilities for sinus radiography. DESIGN: Radiograph ... Full text Link to item Cite

The rational clinical examination [1]

Journal article Journal of the American Medical Association · 1992 Full text Cite

Ultrasonic diagnosis of appendicitis.

Journal article Br J Hosp Med · October 1991 Link to item Cite

Renal colic. Utility of the plain abdominal roentgenogram.

Journal article Arch Intern Med · August 1991 We conducted a retrospective cohort study of 85 consecutive symptomatic patients to evaluate the sensitivity, specificity, and predictive value of plain abdominal roentgenography (PAR) compared with clinical evaluation alone in diagnosis and treatment of r ... Full text Link to item Cite

MEDICAL WASTE-DISPOSAL IN THE HOME CARE SETTING

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · August 1, 1991 Link to item Cite

A comparison of Collins and UW solutions for cold ischemic preservation of the rat liver.

Journal article J Surg Res · July 1991 A new solution which can extend successful preservation times for hepatic allografts was recently developed at the University of Wisconsin (UW). To examine the mechanism of improved viability using this solution, we developed a model of orthotopic hepatic ... Full text Link to item Cite

Serials Cataloging in 1989

Journal article The Serials Librarian · June 1991 Full text Cite

Eosinophil cationic protein's role in human hepatic allograft rejection.

Journal article Hepatology · June 1991 Although it is known that eosinophils consistently infiltrate rejecting human liver allografts, their function is unknown. Infiltrating eosinophils can release a cytotoxic substance, eosinophil cationic protein. Furthermore, eosinophil cationic protein may ... Link to item Cite

Morphometric inflammatory cell analysis of human liver allograft biopsies.

Journal article Transplantation · April 1991 To quantitate the inflammatory cell response within the portal tracts of liver allografts during acute rejection, we retrospectively and in a blinded fashion reviewed 431 biweekly, protocol, core allograft biopsies in 58 consecutive adult recipients. Follo ... Full text Link to item Cite

Reversal of cardiac dysfunction secondary to type 1 primary hyperoxaluria after combined liver-kidney transplantation.

Journal article Am J Med · April 1991 A 23-year-old man with type 1 primary hyperoxaluria, renal failure, and oxalosis developed a severe cardiomyopathy while awaiting combined liver-kidney transplantation. This manifested as radiographic cardiomegaly, a dilated hypokinetic left ventricle with ... Link to item Cite

LACK OF SEASONAL VARIABILITY FOR ACUTE AND SUBACUTE SINUSITIS

Journal article CLINICAL RESEARCH · April 1, 1991 Link to item Cite

Technique for splanchnic transplantation.

Journal article J Pediatr Surg · January 1991 The combination of short-bowel syndrome and liver failure in infancy is inevitably fatal. We describe the details of a technique for simultaneous implantation of both the bowel and the liver that leaves the native bowel undisturbed and avoids entering the ... Full text Link to item Cite

Serials Cataloging Trends and Developments

Journal article The Serials Librarian · August 2, 1990 Full text Cite

Diagnosis of major depression in cancer patients according to four sets of criteria.

Journal article Am J Psychiatry · August 1990 Diagnoses of major depression in 152 cancer patients differed as much as 13% depending on the diagnostic system used. The Beck Depression Inventory and the Hamilton Rating Scale for Depression were useful tools for screening patients with depressive sympto ... Full text Link to item Cite

Effect of imuthiol on Biver cells and lymphocytes proliferation

Conference European Journal of Pharmacology · July 1990 Full text Cite

Case of the month. A Chinese puzzle.

Journal article Br J Radiol · May 1990 Full text Link to item Cite

Liver transplantation. New hope for many patients.

Journal article Postgrad Med · February 1, 1990 Because of the broad range of physiologic problems and the many potential sources of complications, liver transplantation patients require contributions from virtually the complete spectrum of medical science. The evolving specialty of liver transplantatio ... Full text Link to item Cite

Distress associated with cancer as measured by the illness distress scale.

Journal article Psychosomatics · 1990 Over 400 cancer patients were given the Illness Distress Scale (IDS), a brief measure of the physical and emotional distress related to serious illness. Physical manifestations of the disease proved to be the source of greatest discomfort among these patie ... Full text Link to item Cite

Transplantation of Abdominal Viscera-Reply

Journal article JAMA: The Journal of the American Medical Association · September 1, 1989 Full text Cite

CORRECTION

Journal article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · July 14, 1989 Link to item Cite

In vitro evidence for B cell dysfunction in patients with chronic liver disease.

Journal article J Clin Lab Immunol · April 1989 Patients with chronic liver disease have been reported to have multiple immunologic abnormalities. We evaluated immune function in 40 such patients. The patient group had a decreased proportion of CD3 positive cells compared to controls (54.2 +/- 13.2 vs 6 ... Link to item Cite

Splanchnic transplantation. An approach to the infant dependent on parenteral nutrition who develops irreversible liver disease.

Journal article JAMA · March 10, 1989 Two infants with short-bowel syndrome and liver failure associated with obligatory parenteral nutrition received a composite allograft that consisted of en bloc liver, stomach, duodenum, pancreas, jejunum, and ileum. Solutions to the fatal complications in ... Full text Link to item Cite

Hemodynamic study following liver transplantation.

Journal article Transplant Proc · February 1989 Link to item Cite

An analysis of the determinants of hepatic allograft rejection using stepwise logistic regression.

Journal article Transplantation · January 1989 Hepatic allograft rejection is currently diagnosed using both histologic and clinical criteria. The purpose of this study is to extract data from the allograft biopsy, which can establish the diagnosis of rejection with more precision. A total of 566 allog ... Full text Link to item Cite

Blood and graft eosinophilia as predictors of rejection in human liver transplantation.

Journal article Transplantation · January 1989 This study attempts to define the relationship of blood and graft eosinophilia to acute hepatic allograft rejection. Sixty liver transplant patients were studied for the first 30 days postoperatively, with daily serum bilirubin and liver enzyme levels, whi ... Full text Link to item Cite

Serials Cataloging in 1987

Journal article The Serials Librarian · November 1988 Full text Cite

TECHNOLOGY-TRANSFER - FROM NON-PROFIT RESEARCH TO PROFIT - INDUSTRY VIEW

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · September 25, 1988 Link to item Cite

MULTI-SPECIALTY MANAGEMENT OF LOWER-EXTREMITY AMPUTEE UTILIZING SCIATIC BLOCK

Conference ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION · September 1988 Link to item Cite

Effect of pretransplant graft irradiation on canine intestinal transplantation.

Journal article Surg Gynecol Obstet · September 1988 This study was done to define the tolerance of ex vivo administered irradiation to intestinal allograft and to assess the effect of irradiation on the incidence and severity of rejection and graft versus host disease after intestinal transplantation in dog ... Link to item Cite

Growth hormone deficiency and the measurement of somatomedin C/IGF-I: the influence of sexual maturation.

Journal article Clin Endocrinol (Oxf) · April 1988 Fifty-nine short children 2-19 years, 25 females and 34 males, were studied for clinical and biochemical evidence of growth hormone deficiency (GHD). Group 1 (n = 32), mean height SDS -3.26 +/- 1.5, mean retardation of bone age 2 years, had a mean peak GH ... Full text Link to item Cite

Effects of continuous arteriovenous hemofiltration on cardiopulmonary abnormalities during anesthesia for orthotopic liver transplantation.

Journal article Anesth Analg · April 1988 Orthotopic liver transplantation (OLT) often involves large blood loss and replacement, as well as administration of large amounts of blood products to correct coagulation defects. Renal free water excretion is often impaired in end-stage liver disease and ... Link to item Cite

Serials Cataloging in 1986

Journal article The Serials Librarian · November 1987 Full text Cite

Socioeconomic aspects of hepatic transplantation.

Journal article Am J Gastroenterol · November 1987 The outcome, cost, length of hospital stay, and extent of rehabilitation were assessed in a series of 55 consecutive patients who received hepatic transplants between May 1982 and June 1985. In the same geographic region, medical costs for patients dying o ... Link to item Cite

ACUTE REJECTION FOLLOWING HEPATIC TRANSPLANTATION

Conference AMERICAN JOURNAL OF GASTROENTEROLOGY · September 1987 Link to item Cite

Serials Cataloging with AACR2

Journal article The Serials Librarian · August 24, 1987 Full text Cite

Current status of liver transplantation.

Journal article Hosp Pract (Off Ed) · July 15, 1987 Full text Link to item Cite

Long-term effects of cyclosporine on renal function in liver transplant recipients.

Journal article Transplantation · May 1987 The long-term effects of cyclosporine on renal function were evaluated in eleven liver transplant recipients over a 6-26-month follow-up period. Renal hemodynamic function (glomerular filtration rate [GFR], effective renal plasma flow [ERPF]) fell 60% post ... Full text Link to item Cite

STRUCTURE-ACTIVITY-RELATIONSHIPS OF INSECTICIDES UTILIZING AN NMR METHOD FOR ESTIMATING SIGMA-STAR

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 5, 1987 Link to item Cite

Congenital cystic adenomatoid malformation of the lung associated with prune belly syndrome.

Journal article J Pediatr Surg · April 1987 A case of the rare association of congenital cystic adenomatoid malformation of the lung with prune belly syndrome and brief comments on its pathogenesis is presented. ... Full text Link to item Cite

Requirements for primary T cell activation.

Journal article Transplant Proc · February 1987 Link to item Cite

Correction: Author's Name Omitted

Journal article Annals of Internal Medicine · September 1, 1986 Full text Cite

HEPATIC-DYSFUNCTION FOLLOWING HEPATIC TRANSPLANTATION

Conference AMERICAN JOURNAL OF GASTROENTEROLOGY · September 1986 Link to item Cite

Serial immunologic studies in recipients of hepatic allografts.

Journal article Clin Immunol Immunopathol · August 1986 Thirty recipients of hepatic allografts had serial immunologic evaluations. Prior to transplant, patients had marked depression of lymphocyte subsets and impaired in vitro immunoglobulin synthesis, while phytohemagglutinin responsiveness was similar to tha ... Full text Link to item Cite

Survival following hepatic transplantation in the cyclosporine era.

Journal article Am Surg · June 1986 In a series of 50 consecutive patients receiving 55 hepatic transplants, the 6-month survival was 76 per cent. Mortality was considerably higher in patients with complications of advanced liver failure (56%) than in patients that were not hospital-confined ... Link to item Cite

A technique for safe, frequent biopsy of the liver after hepatic transplantation.

Journal article Surg Gynecol Obstet · June 1986 Valuable information can be obtained from the hepatic biopsy in patients undergoing hepatic transplantation. Biopsy of the liver can be repeatedly performed safely even in patients with severely deranged clotting function by using the technique described h ... Link to item Cite

Biliary excretion of aluminum in aluminum osteodystrophy with liver disease.

Journal article Ann Intern Med · June 1986 Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary an ... Full text Link to item Cite

Cholestatic jaundice after hepatic transplantation. A nonimmunologically mediated event.

Journal article Am J Surg · January 1986 Serial liver biopsy and close clinical monitoring in 55 consecutive hepatic allografts have disclosed a syndrome of cholestatic jaundice that simulates rejection. This syndrome is associated with distinct histologic findings and resolves spontaneously with ... Full text Link to item Cite

Cyclosporine disposition in the dog. Comparison of radioimmunoassay with high-performance liquid chromatographic assay and pharmacokinetics following intravenous administration.

Journal article Transplantation · November 1985 Radioimmunoassay (RIA) and high performance liquid chromatography (HPLC) with ultraviolet absorbance detection have been compared as potential tools for cyclosporine pharmacokinetic studies in dogs. RIA clearly affords greater assay sensitivity, although c ... Link to item Cite

Autotransfusion in hepatic transplantation.

Journal article Am Surg · November 1985 Hepatic transplantation is often accompanied by a large volume of intraoperative blood loss which may place extraordinary transfusion demands on a community blood bank. In an effort to conserve blood bank resources, intraoperative autotransfusion has recen ... Link to item Cite

Methyldopa therapy and outcome in cadaveric renal transplantation.

Journal article South Med J · September 1985 Methyldopa therapy for hypertension after renal transplantation could affect graft outcome adversely, since methyldopa inhibits suppressor cells. To study effects of methyldopa on transplant outcome, we analyzed prospective data on 1,648 hypertensive, firs ... Full text Link to item Cite

Biopsy-directed immunosuppression following hepatic transplantation in man.

Journal article Transplantation · June 1985 Patients undergoing orthotopic hepatic transplantation were studied with routinely available liver function studies and serial hepatic biopsies. Rejection was diagnosed only if confirmed histologically. Cyclosporine and a rapidly decreasing dose of cortico ... Full text Link to item Cite

Liver transplantation with cyclosporine and low-dose corticosteroids.

Journal article Am Surg · March 1985 Twenty consecutive patients receiving 21 hepatic transplants were treated with cyclosporine and low-dose corticosteroids. Survival was 80 per cent at 30 days, 75 per cent at 6 months, and 65% in the 6-17 months follow-up period. Compared with earlier serie ... Link to item Cite

MYOFIBRILLAR ULTRASTRUCTURE AND MORPHOMETRY IN POULTRY

Conference JOURNAL OF ELECTRON MICROSCOPY TECHNIQUE · 1985 Link to item Cite

Bacterial removal of mercury from sewage.

Journal article Biotechnol Bioeng · November 1984 Mercury-resistant bacteria, which are able to reduce mercuric ion (Hg(2+)) to metallic mercury (Hg(0)), were examined for their ability to remove mercury from waste-water aerobically. Growth studies in artificial medium indicated that mercury increases the ... Full text Link to item Cite

Portal vein obstruction in patients requiring hepatic resection or transplantation.

Journal article Am Surg · September 1984 Four patients with chronic portal vein occlusion (or near occlusion) who required major hepatic resection or transplantation are described. In each case, portal vein patency was restored, and objective evidence of long-term patency is presented in three pa ... Link to item Cite

Pre-1950 Serials in OCLC

Journal article The Serials Librarian · May 7, 1984 Full text Cite

The distal splenorenal shunt in alcoholic patients. A training program's experience.

Journal article Am Surg · January 1984 Eighteen alcoholic patients who had bled from esophageal varices underwent elective distal splenorenal shunt. None died in surgery, and morbidity was minimal. Two-year survival for the group was 84 per cent. All five patients who have abstained from alcoho ... Link to item Cite

Splenectomy and death in renal transplant patients.

Journal article Arch Surg · July 1983 To determine any association of splenectomy and death, 191 recipients of a single renal transplant were reviewed. Pretransplant splenectomy was performed in 90(47%) patients and the spleen was retained ("spleen-retaining") in 101 (53%). Sixty-eight patient ... Full text Link to item Cite

Cyclosporine in transplantation of the liver in the dog.

Journal article Surg Gynecol Obstet · June 1983 Orthotopic hepatic transplantation was performed upon 29 dogs. Four dogs received no immunosuppressant, 12 received cyclosporine and 13 received azathioprine. Dogs treated with cyclosporine at a dose of 20 milligrams per kilogram yielded histologic and fun ... Link to item Cite

The structure of films formed by γ-aminopropyltriethoxysilane adsorbed onto copper

Journal article Journal of Colloid and Interface Science · February 1983 Full text Cite

TO SERVE WITH HONOR - GABRIEL,RA

Journal article JOURNAL OF POLITICAL & MILITARY SOCIOLOGY · 1983 Link to item Cite

BEYOND THE BATTLEFIELD - THE NEW MILITARY PROFESSIONALISM - SARKESIAN,SC

Journal article JOURNAL OF POLITICAL & MILITARY SOCIOLOGY · 1983 Link to item Cite

Asymptomatic pulmonary embolism. A common event in high risk patients.

Journal article Ann Surg · March 1982 Ventilation and perfusion lung scans were obtained before and at weekly intervals following hip surgery or major amputation in 158 patients. Pulmonary arteriograms were obtained in 21 of 33 patients developing perfusion patterns strongly suggesting embolis ... Full text Link to item Cite

Ultrasound measurement of contraction response of the gallbladder: comparison with the radionuclide test for cystic duct patency.

Journal article Clin Nucl Med · March 1982 Two tests of cystic duct patency were compared in 37 patients with suspected acute cholecystitis. Ultrasound (US) measurement of gallbladder contraction induced by 40 Ivy dog units of cholecystokinin (CCK) was followed by the radionuclide (RN) test for cys ... Full text Link to item Cite

ADSORPTION OF GAMMA-AMINOPROPYLTRIETHOXYSILANE ONTO COPPER

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 1982 Link to item Cite

Current Challenges in Educating for Parenthood

Journal article Family Relations · October 1981 Full text Cite

Structure and properties of organosilane primers for adhesive bonding

Journal article Applications of Surface Science · January 1981 Full text Cite

Serum dehydroepiandrosterone (DHA) and sulphate (DHAS) after acute growth hormone therapy.

Journal article Acta Paediatr Scand · May 1980 To test the hypothesis that growth hormone (hGH) may increase adrenal androgen production dehydroepiandrosterone (DHA) and its sulphate (DHAS) concentrations were measured by radioimmunoassay in the serum from 7 children with growth hormone deficiency, 2 o ... Full text Link to item Cite

HARVEST OF DRY BEANS IN THE PRE-DRY STAGE OF DEVELOPMENT - EFFECT ON YIELD AND PROCESSED PRODUCT QUALITY

Journal article JOURNAL OF THE AMERICAN SOCIETY FOR HORTICULTURAL SCIENCE · 1980 Link to item Cite

Regeneration of the uterine mucosa after delivery, with especial reference to the placental site

Journal article American Journal of Obstetrics and Gynecology · July 1979 Full text Cite

Linear integral equations with singular normal kernels of class I

Journal article Journal of Mathematical Analysis and Applications · April 1979 Full text Cite

EFFECTS OF CULTIVAR, IRRIGATION, ETHEPHON, AND HARVEST DATE ON THE YIELD AND QUALITY OF PROCESSING TOMATOES

Journal article JOURNAL OF THE AMERICAN SOCIETY FOR HORTICULTURAL SCIENCE · 1979 Link to item Cite

Failure of low dose heparin to prevent pulmonary embolism after hip surgery or above the knee amputation.

Journal article Ann Surg · October 1978 In a randomized, double-blind trial, 5,000 USP units of sodium heparin or saline were give subcutaneously at least two hours before surgery and at 12 hour intervals thereafter to patients requiring total hip replacement, surgical correction of hip fracture ... Full text Link to item Cite

Antagonism by indomethacin of neurogenic hyperthermia produced by unilateral puncture of the anterior hypothalamic/preoptic region.

Journal article J Physiol · November 1977 1. In unanaesthetized rats, restrained at an ambient temperature of 24 degrees C, the anterior hypothalamic/preoptic (AH/PO) region was lesioned unilaterally by acute mechanical puncture.2. In control (no pre-treatment) rats, unilateral AH/PO puncture prod ... Full text Link to item Cite

Nyctohemeral secretion of growth hormone in normal children of short stature and in children with hypopituitarism and intrauterine growth retardation.

Journal article Clin Endocrinol (Oxf) · May 1977 A continuous blood sampling technique has been used to monitor human growth hormone (GH) during sleep in fourteen normal short children (age range 6.5-15.0 years), twelve hypopituitary children (2.8-17.3 years), three children with psychosocial GH deficien ... Full text Link to item Cite

An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia.

Journal article Brain Res · January 21, 1977 Experiments designed to ascertain the site or sites within the brain where prostaglandins act to evoke hyperthermia were carried out. At an ambient temperature of 20 degrees C, microinjections of PGE1 (50-100 ng) or saline vehicle were made in restrained r ... Full text Link to item Cite

FOR PROCESSING - SAVOY OR SMOOTH LEAF SPINACH

Journal article ARKANSAS FARM RESEARCH · 1977 Link to item Cite

RESPONSE OF TOMATO CULTIVARS TO ETHEPHON

Journal article ARKANSAS FARM RESEARCH · 1977 Link to item Cite

A study of pituitary function in patients with idiopathic hemochromatosis.

Journal article J Clin Endocrinol Metab · October 1976 Pituitary function was assessed in twelve male patients with idiopathic hemochromatosis. Though clinical features suggestive of hypogonadism were noted in nine cases, impaired pituitary function was demonstrated in only two instances. Our findings suggest ... Full text Link to item Cite

Luteinizing release hormone tests in impotent diabetic males.

Journal article Diabetes · October 1976 Assessment of pituitary-gonadal function was made in impotent diabetic males using luteinizing hormone-release hormone tests. Serum testosterone, sex-hormone-binding globulin capacity, and basal and incremental gonadotrophin concentrations in the impotent ... Full text Link to item Cite

The control of gonadotrophin release in women with hyperprolactinaemic amenorrhoea: effect of oestrogen and progesterone on the LH and FSH response to LHRH.

Journal article Clin Endocrinol (Oxf) · September 1976 The effect of the administration of oestradiol benzoate and of progesterone on the subsequent response to LHRH has been investigated in women with hyperprolactinaemia. There was an amplification in the release of LH in four out of ten patients and of FSH i ... Full text Link to item Cite

Basal serum prolactin values and responses to the administration of thyrotrophin releasing hormone (TRH) in women with amenorrhoea.

Journal article Br J Obstet Gynaecol · June 1976 Basal prolactin concentrations were measured in 77 patients presenting with amenorrhoea; 17 per cent were found to have hyperprolactinaemia. The release of prolactin in response to a standard dose of thyrotrophin releasing hormone for amenorrhoeic subjects ... Full text Link to item Cite

A radioimmunoassay for the estimation of serum dehydroepiandrosterone sulphate in normal and pathological sera.

Journal article Clin Chim Acta · November 15, 1975 A radioimmunoassay is described for the measurement of dehydroepiandrosterone sulphate in serum. The method requires 0.1 ml of serum that needs no purification other than a single ether extraction. It is both rapid and economical, procedural losses are sma ... Full text Link to item Cite

Venous thrombosis and pulmonary embolism.

Journal article Surg Gynecol Obstet · October 1975 Link to item Cite

Sex hormone levels and gonadotrophin release in the polycystic ovary syndrome.

Journal article Clin Endocrinol (Oxf) · May 1975 The response to synthetic luteinizing hormone-releasing hormone was studied in eighteen patients with the polycystic ovary syndrome. The release of follicle-stimulating hormone was similar to that found in normal women. The mean response of luteinizing hor ... Full text Link to item Cite

Diurnal variation in algal acetylene reduction (nitrogen fixation) in situ.

Journal article Plant Physiol · February 1975 Diurnal variation in algal nitrogen fixation was studied in Lake Mendota, Wisconsin, during the summers of 1971 to 1973. Approximately two-thirds of the daily acetylene reduction in the surface decimeter occurred before noon. The decline in acetylene reduc ... Full text Link to item Cite

Pulmonary embolism after amputation of the lower extremity.

Journal article Surg Gynecol Obstet · February 1975 Patients requiring amputation of the lower extremity for arteriosclerosis are at high risk for the development of venous thrombosis and pulmonary embolism. Inapparent venous thrombosis was discovered in the amputated leg at operation in eight patients. Pul ... Link to item Cite

O-Benzylmonoperoxycarbonic acid. New oxygenating reagent

Journal article The Journal of Organic Chemistry · October 1974 Full text Cite

Maturity Cards: An Alternative to the Letter Grade System

Journal article The Journal of Higher Education · November 1973 Full text Cite