John Wiley Williams Jr.

Journal article J Gen Intern Med · December 2017 Featured Publication BACKGROUND: New payments from Medicare encourage behavioral health services to be integrated into primary care practice activities. OBJECTIVE: To evaluate the financial impact for primary care practices of integrating behavioral health services. DESIGN: Mi ... Full text Link to item Cite

Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review.

Journal article Ann Intern Med · February 7, 2017 Featured Publication BACKGROUND: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these p ... Full text Link to item Cite

Reporting of Sex Effects by Systematic Reviews on Interventions for Depression, Diabetes, and Chronic Pain.

Journal article Ann Intern Med · August 2, 2016 Featured Publication Systematic reviews (SRs) have the potential to contribute uniquely to the evaluation of sex and gender differences (termed "sex effects"). This article describes the reporting of sex effects by SRs on interventions for depression, type 2 diabetes mellitus, ... Full text Link to item Cite

Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review.

Journal article Ann Intern Med · August 4, 2015 Featured Publication BACKGROUND: The use of electronic interventions (e-interventions) may improve treatment of alcohol misuse. PURPOSE: To characterize treatment intensity and systematically review the evidence for efficacy of e-interventions, relative to controls, for reduci ... Full text Link to item Cite

Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

Journal article Ann Intern Med · July 15, 2014 Featured Publication BACKGROUND: Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model ma ... Full text Link to item Cite

Does this patient have generalized anxiety or panic disorder?: The Rational Clinical Examination systematic review.

Journal article JAMA · July 2, 2014 Featured Publication IMPORTANCE: In primary care settings, generalized anxiety disorder (GAD) and panic disorder are common but underrecognized illnesses. Identifying accurate and feasible screening instruments for GAD and panic disorder has the potential to improve detection ... Full text Link to item Cite

The patient centered medical home. A systematic review.

Journal article Ann Intern Med · February 5, 2013 Featured Publication BACKGROUND: The patient-centered medical home (PCMH) describes mechanisms for organizing primary care to provide high quality care across the full range of individuals' health care needs.It is being widely implemented by provider organizations and third pa ... Full text Link to item Cite

Taking healthcare interventions from trial to practice.

Journal article BMJ · August 13, 2010 Featured Publication Full text Link to item Cite

Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

Journal article Ann Intern Med · August 3, 2010 Featured Publication BACKGROUND: Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline. PURPOSE: To summarize evidence about putative risk and protective factors for cognitive decline in older adults and t ... Full text Link to item Cite

Developing a national dissemination plan for collaborative care for depression: QUERI Series.

Journal article Implement Sci · December 31, 2008 Featured Publication BACKGROUND: Little is known about effective strategies for disseminating and implementing complex clinical innovations across large healthcare systems. This paper describes processes undertaken and tools developed by the U.S. Department of Veterans Affairs ... Full text Link to item Cite

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies.

Journal article BMJ · May 17, 2008 Featured Publication The GRADE system can be used to grade the quality of evidence and strength of recommendations for diagnostic tests or strategies. This article explains how patient-important outcomes are taken into account in this process ... Full text Link to item Cite

Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes and depression.

Journal article Diabetes Care · February 2006 Featured Publication OBJECTIVE: To determine the incremental cost-effectiveness and net benefit of a depression collaborative care program compared with usual care for patients with diabetes and depression. RESEARCH DESIGN AND METHODS: This article describes a preplanned subgr ... Full text Link to item Cite

Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system.

Journal article BMC Health Serv Res · March 23, 2005 Featured Publication BACKGROUND: Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key short ... Full text Link to item Cite

The effectiveness of depression care management on diabetes-related outcomes in older patients.

Journal article Ann Intern Med · June 15, 2004 Featured Publication BACKGROUND: Depression frequently occurs in combination with diabetes mellitus, adversely affecting the course of illness. OBJECTIVE: To determine whether enhancing care for depression improves affective and diabetic outcomes in older adults with diabetes ... Full text Link to item Cite

Going to scale: re-engineering systems for primary care treatment of depression.

Journal article Ann Fam Med · 2004 Featured Publication BACKGROUND: Recent trials have shown improved depression outcomes with chronic care models. We report the methods of a project that assesses the sustainability and transportability of a chronic care model for depression and change strategy. METHODS: In a r ... Full text Link to item Cite

Helping journalists get it right: a physicians's guide to improving health care reporting.

Journal article J Gen Intern Med · February 2003 Featured Publication News reports are the way that most people, including many physicians and scientists, first learn about new developments in medicine. Because these reports can raise awareness, influence behavior, and confer credibility, physicians should share responsibili ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal article Cochrane Database Syst Rev · 2003 Featured Publication BACKGROUND: For adults seeking care in ambulatory medical practices, sinusitis is the most common diagnosis treated with antibiotics. OBJECTIVES: We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are mos ... Full text Link to item Cite

Is this patient clinically depressed?

Journal article JAMA · March 6, 2002 Featured Publication CONTEXT: Depressive disorders are highly prevalent in the general population, but recognition and accurate diagnosis are made difficult by the lack of a simple confirmatory test. OBJECTIVE: To review the accuracy and precision of depression questionnaires ... Full text Link to item Cite

Treatment of dysthymia and minor depression in primary care: A randomized controlled trial in older adults.

Journal article JAMA · September 27, 2000 Featured Publication CONTEXT: Insufficient evidence exists for recommendation of specific effective treatments for older primary care patients with minor depression or dysthymia. OBJECTIVE: To compare the effectiveness of pharmacotherapy and psychotherapy in primary care setti ... Full text Link to item Cite