Jyothi Poovandur Rao

Journal article J Am Med Inform Assoc · April 1, 2017 OBJECTIVE: We assessed the sensitivity and specificity of 8 electronic health record (EHR)-based phenotypes for diabetes mellitus against gold-standard American Diabetes Association (ADA) diagnostic criteria via chart review by clinical experts. MATERIALS ... Full text Link to item Cite

Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions.

Journal article Am J Hypertens · August 2015 BACKGROUND: The relative effectiveness of 3 approaches to blood pressure control-(i) an intensive lifestyle intervention (ILI) focused on weight loss, (ii) frequent goal-based monitoring of blood pressure with pharmacological management, and (iii) educatio ... Full text Link to item Cite

Human brain glycogen metabolism during and after hypoglycemia.

Journal article Diabetes · September 2009 OBJECTIVE: We tested the hypotheses that human brain glycogen is mobilized during hypoglycemia and its content increases above normal levels ("supercompensates") after hypoglycemia. RESEARCH DESIGN AND METHODS: We utilized in vivo (13)C nuclear magnetic re ... Full text Link to item Cite

Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function.

Journal article Diabetes · November 2008 OBJECTIVE: Long-standing type 1 diabetes is associated with deficits on neurocognitive testing that suggest central white matter dysfunction. This study investigated whether diffusion tensor imaging (DTI), a type of magnetic resonance imaging that measures ... Full text Link to item Cite

Effects of intensive glucose lowering in type 2 diabetes.

Journal article N Engl J Med · June 12, 2008 BACKGROUND: Epidemiologic studies have shown a relationship between glycated hemoglobin levels and cardiovascular events in patients with type 2 diabetes. We investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce ca ... Full text Link to item Cite

Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: Design and methods

Journal article American Journal of Cardiology · June 18, 2007 Most patients with type 2 diabetes mellitus develop cardiovascular disease (CVD), with substantial loss of life expectancy. Nonfatal CVD contributes greatly to excess healthcare costs and decreased quality of life in patients with diabetes. The current epi ... Full text Cite

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism.

Journal article Am J Physiol Endocrinol Metab · March 2007 The adult brain relies on glucose for its energy needs and stores it in the form of glycogen, primarily in astrocytes. Animal and culture studies indicate that brain glycogen may support neuronal function when the glucose supply from the blood is inadequat ... Full text Link to item Cite

Regulation of cerebral glucose metabolism.

Journal article Minerva Endocrinol · June 2006 The brain uses glucose as a primary fuel for energy generation. Glucose gains entry into the brain by facilitated diffusion across the blood-brain barrier. Glucose transport may adapt during changes in cerebral glucose metabolism, neural activation and cha ... Link to item Cite