Scholars@Duke
Kamrouz Ghadimi

Kamrouz Ghadimi

Adjunct Associate Professor in the Department of Anesthesiology
Anesthesiology, Cardiothoracic
kamrouz.ghadimi@duke.edu
40 Medicine Circle, Box 3094, Durham, NC 27710
2933 Woodstone Lane, Avon, OH 44011

Scholarly Works - Journal articles

The association of estimated citrate load with frozen plasma versus four-factor prothrombin complex concentrate for coagulopathy after cardiac surgery: a post hoc exploratory analysis of the FARES-II randomised controlled trial.

Journal article BJA Open · September 2026 BACKGROUND: Frozen plasma (FP) is the standard haemostatic therapy after cardiopulmonary bypass, but recent trials indicate that FP is inferior to four-factor prothrombin complex concentrate (PCC). Citrate content may contribute to this difference. We comp ... Full text Link to item Cite

Management of Shock After Cardiac Surgery.

Journal article Cardiol Clin · August 2026 Postcardiotomy shock (PCS) is a complex, high-mortality complication following cardiac surgery, driven by cardiopulmonary bypass-related inflammation, vasoplegia, myocardial dysfunction, and pulmonary hypertension. Conventional shock definitions are poorly ... Full text Link to item Cite

Frailty assessment and candidate optimization before cardiothoracic transplantation.

Journal article JHLT Open · May 2026 Frailty is an important syndrome in an aging thoracic transplant population, particularly in the context of end-stage cardiopulmonary disease. In this review, we discuss the core problem of lack of physiologic reserve in these patients and its relationship ... Full text Link to item Cite

A retrospective pilot crossover study of protocolized transition from inhaled nitric oxide to inhaled epoprostenol in adult cardiothoracic surgery.

Journal article JHLT Open · May 2026 INTRODUCTION: Inhaled pulmonary vasodilators (iPVDs), including inhaled nitric oxide (iNO) and inhaled epoprostenol (iEPO), are commonly used in the perioperative management of right ventricular dysfunction, pulmonary hypertension, and hypoxemia in cardiot ... Full text Link to item Cite

Variations in Intraoperative Opioid Use in Cardiac Surgical Patients With Midline Sternotomy.

Journal article Semin Cardiothorac Vasc Anesth · April 24, 2026 High-dose opioid use in cardiac anesthesia has been challenged due to its association with increased postoperative complications. We retrospectively compared postoperative opioid consumption in a cohort of adult cardiac surgery patients who received low, m ... Full text Link to item Cite

Management of Direct Oral Anticoagulants in Adult Patients Undergoing Cardiac Surgery: A Joint Consensus Statement by the Society of Cardiovascular Anesthesiologists and the Society of Thoracic Surgeons.

Journal article Anesth Analg · April 1, 2026 The Society of Cardiovascular Anesthesiologists (SCA) along with the Society of Thoracic Surgeons (STS) sought to improve the care of adult patients undergoing cardiac surgery who are taking direct oral anticoagulants (DOACs), such as factor Xa and direct ... Full text Link to item Cite

Management of Direct Oral Anticoagulants in Adult Patients Undergoing Cardiac Surgery: A Joint Consensus Statement by the Society of Cardiovascular Anesthesiologists and The Society of Thoracic Surgeons.

Journal article Ann Thorac Surg · April 2026 The Society of Cardiovascular Anesthesiologists (SCA) along with The Society of Thoracic Surgeons (STS) sought to improve the care of adult patients undergoing cardiac surgery who are taking direct oral anticoagulants (DOACs), such as factor Xa and direct ... Full text Link to item Cite

Outcomes of central versus peripheral arterial cannulation for intraoperative extracorporeal membrane oxygenation support in lung transplantation.

Journal article J Heart Lung Transplant · February 2026 BACKGROUND: Intraoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) is becoming the most common mode of extracorporeal life support (ECLS) in lung transplantation (LTx). We compared rates of primary graft dysfunction (PGD) and other perio ... Full text Link to item Cite

Perioperative use of factor concentrates and blood products-a survey of clinical practices in the United States: communication from the ISTH Subcommittee on Perioperative and Critical Care.

Journal article J Thromb Haemost · December 2025 BACKGROUND: Educational efforts to improve perioperative physician knowledge on managing bleeding and oral anticoagulants may have influenced clinical practice. This study evaluated management strategies for major bleeding and use of fibrinogen and prothro ... Full text Link to item Cite

Pain Trajectories After Cardiac Surgery Performed Via Midline Sternotomy.

Journal article J Cardiothorac Vasc Anesth · December 2025 OBJECTIVES: Acute pain after cardiac surgery performed via midline sternotomy is reported to be moderate to severe in intensity in up to three-quarters of patients in the early postoperative period. This work was designed to describe different pain traject ... Full text Link to item Cite

Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anaesthesia (THRIVE) randomised controlled trial in the USA: A protocol.

Journal article BMJ Open · September 14, 2025 INTRODUCTION: Millions of patients receive general anaesthesia every year with either propofol total intravenous anaesthesia (TIVA) or inhaled volatile anaesthesia (INVA). It is currently unknown which of these techniques is superior in relation to patient ... Full text Link to item Cite

Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.

Journal article JAMA · May 27, 2025 IMPORTANCE: Excessive bleeding is a common and prognostically important complication of cardiac surgery. For bleeding related to coagulation factor deficiency, frozen plasma is the most used therapy. Preliminary trials indicate that 4-factor prothrombin co ... Full text Open Access Link to item Cite

Perioperative Bleeding Risk in Lung Transplantation After Previous Cardiothoracic Surgery.

Journal article Clin Transplant · April 2025 INTRODUCTION: Previous cardiothoracic surgery (CTS) is associated with a significant risk of perioperative bleeding in lung transplantation (LT). The types of prior surgery have not been well-defined. We aimed to quantify the risk of perioperative bleeding ... Full text Link to item Cite

Clinician attitudes, opinions and practice patterns regarding inotrope use for cardiac surgery in the USA: a multicentre mixed methods study protocol.

Journal article BMJ Open · March 27, 2025 INTRODUCTION: Cardiac inotrope medications administered to cardiac surgical patients carry steep risk-benefit trade-offs, yet wide inter-institutional variation exists in inotrope practices. Despite known wide variation in use of any inotrope for cardiac s ... Full text Open Access Link to item Cite

Thrombin generation after prothrombin complex concentrate or plasma transfusion during cardiac surgery.

Journal article J Thromb Thrombolysis · February 2025 Thrombin generation (TG) is reduced after cardiac surgery using cardiopulmonary bypass (CPB), contributing to coagulopathy and bleeding. Plasma transfusion or four-factor prothrombin complex concentrate (PCC) are commonly used to treat coagulopathic bleedi ... Full text Link to item Cite

Heart failure diagnostic accuracy, intraoperative fluid management, and postoperative acute kidney injury: a single-centre prospective observational study.

Journal article Br J Anaesth · January 2025 BACKGROUND: The accurate diagnosis of heart failure (HF) before major noncardiac surgery is frequently challenging. The impact of diagnostic accuracy for HF on intraoperative practice patterns and clinical outcomes remains unknown. METHODS: We performed an ... Full text Open Access Link to item Cite

Correction

Journal article Journal of the American College of Cardiology · December 2024 Full text Cite

2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal article Circulation · November 5, 2024 AIM: The "2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery" provides recommendations to guide clinicians in the perioperative cardiovascular evaluation and management of adult patients ... Full text Open Access Link to item Cite

2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal article J Am Coll Cardiol · November 5, 2024 AIM: The "2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery" provides recommendations to guide clinicians in the perioperative cardiovascular evaluation and management of adult patients ... Full text Open Access Link to item Cite

A multicenter analysis of lung transplantation outcomes comparing donation after circulatory death and donation after brain death.

Journal article JHLT Open · November 2024 BACKGROUND: Donor organ shortage is a barrier to lung transplantation. Donation after circulatory death (DCD) may offer a solution, although it is underutilized. The objective of this study was to compare survival and other postoperative outcomes between D ... Full text Open Access Link to item Cite

Trends in the Utilization of Multiorgan Support Among Adults Undergoing High-risk Cardiac Surgery in the United States.

Journal article J Cardiothorac Vasc Anesth · September 2024 OBJECTIVES: To examine trends in the prevalence of multiorgan dysfunction (MODS), utilization of multi-organ support (MOS), and mortality among patients undergoing cardiac surgery with MODS who received MOS in the United States. DESIGN: Retrospective cohor ... Full text Link to item Cite

A Multi-Center International Analysis of Lung Transplantation Outcomes in Patients With COVID-19.

Journal article Clin Transplant · September 2024 INTRODUCTION: Lung transplantation has become increasingly utilized in patients with COVID-19. While several single-center and UNOS database studies have been published on lung transplants (LTs) for end-stage lung disease (ESLD) from Coronavirus disease 20 ... Full text Open Access Link to item Cite

Finding a common definition of heparin resistance in adult cardiac surgery: communication from the ISTH SSC subcommittee on perioperative and critical care thrombosis and hemostasis.

Journal article J Thromb Haemost · April 2024 Ensuring adequate anticoagulation for patients requiring cardiac surgery and cardiopulmonary bypass (CPB) is important due to the adverse consequences of inadequate anticoagulation with respect to bleeding and thrombosis. When target anticoagulation is not ... Full text Open Access Link to item Cite

Defining heparin resistance: communication from the ISTH SSC Subcommittee of Perioperative and Critical Care Thrombosis and Hemostasis.

Journal article J Thromb Haemost · December 2023 The term heparin resistance (HR) is used by clinicians without specific criteria. We performed a literature search and surveyed our SSC membership to better define the term when applied to medical and intensive care unit patients. The most common heparin d ... Full text Open Access Link to item Cite

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery.

Journal article Circulation · October 24, 2023 Featured Publication BACKGROUND: Right ventricular failure (RVF) is a leading driver of morbidity and death after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation. Inhaled pulmonary-sel ... Full text Open Access Link to item Cite

Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation.

Journal article J Cardiothorac Vasc Anesth · September 2023 OBJECTIVES: The development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product trans ... Full text Open Access Link to item Cite

What's fishy about protamine? Clinical use, adverse reactions, and potential alternatives.

Journal article J Thromb Haemost · July 2023 Protamine, a highly basic protein isolated from salmon sperm, is the only clinically available agent to reverse the anticoagulation of unfractionated heparin. Following intravenous administration, protamine binds to heparin in a nonspecific electrostatic i ... Full text Open Access Link to item Cite

Perioperative Considerations in Management of the Severely Bleeding Coagulopathic Patient.

Journal article Anesthesiology · May 1, 2023 Featured Publication Inherited and acquired coagulopathy are frequently associated with major bleeding in severe trauma, cardiac surgery with cardiopulmonary bypass, and postpartum hemorrhage. Perioperative management is multifactorial and includes preoperative optimization an ... Full text Open Access Link to item Cite

Evaluation and Management of Pulmonary Hypertension in Noncardiac Surgery: A Scientific Statement From the American Heart Association.

Journal article Circulation · April 25, 2023 Featured Publication Pulmonary hypertension, defined as an elevation in blood pressure in the pulmonary arteries, is associated with an increased risk of death. The prevalence of pulmonary hypertension is increasing, with an aging population, a rising prevalence of heart and l ... Full text Open Access Link to item Cite

The impact of race on utilization of durable left ventricular assist device therapy in patients with advanced heart failure.

Journal article J Card Surg · November 2022 BACKGROUND: Heart failure affects >6 million people in the United States alone and is most prevalent in Black patients who suffer the highest mortality risk. Yet prior studies have suggested that Black patients are less likely to receive advanced heart fai ... Full text Open Access Link to item Cite

Hydroxocobalamin or Methylene Blue for Vasoplegic Syndrome in Adult Cardiothoracic Surgery.

Journal article J Cardiothorac Vasc Anesth · February 2022 Featured Publication OBJECTIVE: To compare hydroxocobalamin and methylene blue for the treatment of vasopressor-refractory vasoplegic syndrome (VS) after adult cardiac surgery with cardiopulmonary bypass (CPB). DESIGN: A retrospective, propensity-matched, cohort study was perf ... Full text Open Access Link to item Cite

The Year in Cardiothoracic Critical Care: Selected Highlights from 2019.

Journal article J Cardiothorac Vasc Anesth · January 2022 In 2019, cardiothoracic and vascular critical care remained an important focus and subspecialty. This article continues the annual series to review relevant contributions in postoperative critical care that may affect the cardiac anesthesiologist. Herein, ... Full text Link to item Cite

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.

Journal article JAMA Surg · January 1, 2022 Featured Publication IMPORTANCE: Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhaled epoprostenol (iEPO) has been introduced worldwide as a cost-saving alterna ... Full text Open Access Link to item Cite

COVID-19: Thrombosis, thromboinflammation, and anticoagulation considerations.

Journal article Int J Lab Hematol · July 2021 Featured Publication Vascular endothelial injury is a hallmark of acute infection at both the microvascular and macrovascular levels. The hallmark of SARS-CoV-2 infection is the current COVID-19 clinical sequelae of the pathophysiologic responses of hypercoagulability and thro ... Full text Open Access Link to item Cite

Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

Journal article J Aerosol Med Pulm Drug Deliv · June 2021 Featured Publication Rationale: There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). Objectives: To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 ... Full text Open Access Link to item Cite

Reducing Intubation Time in Adult Cardiothoracic Surgery Patients With a Fast-track Extubation Protocol.

Journal article Crit Care Nurse · June 1, 2021 BACKGROUND: Prolonged intubation after cardiac surgery increases the risk of morbidity and mortality and lengthens hospital stays. Factors that influence the ability to extubate patients with speed and efficiency include the operation, the patient's baseli ... Full text Open Access Link to item Cite

Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.

Journal article J Cardiothorac Vasc Anesth · May 2021 OBJECTIVE: Conventional ultrafiltration (CUF) during cardiopulmonary bypass (CPB) serves to hemoconcentrate blood volume to avoid allogeneic blood transfusions. Previous studies have determined CUF volumes as a continuous variable are associated with posto ... Full text Open Access Link to item Cite

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation.

Journal article Blood Adv · February 9, 2021 Featured Publication Disseminated intravascular coagulation (DIC) is a pathological coagulopathy associated with infection that increases mortality. In DIC, excessive thrombin generation causes symptoms from formation of microthrombi to multiorgan failure; bleeding risks can a ... Full text Open Access Link to item Cite

Clinical outcomes of cardiac surgery patients undergoing therapeutic plasma exchange for heparin-induced thrombocytopenia.

Journal article Vox Sang · February 2021 BACKGROUND AND OBJECTIVES: Heparin-induced thrombocytopenia (HIT) is an antibody-mediated condition that leads to thrombocytopenia and possible thrombosis. Patients with HIT who require cardiac surgery pose a challenge as high doses of heparin or heparin a ... Full text Open Access Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

Journal article J Cardiovasc Transl Res · December 2020 COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbid ... Full text Open Access Link to item Cite

Percutaneous Intervention for Left Ventricular Assist Device Outflow Obstruction.

Journal article Heart Lung Circ · March 2020 Left ventricular assist devices (LVADs) are used to support patients with advanced systolic heart failure (HF). These patients might develop LVAD dysfunction and consequent HF symptoms. Occasionally, outflow graft obstruction is responsible for LVAD dysfun ... Full text Link to item Cite

Using Plasma and Prothrombin Complex Concentrates.

Journal article Semin Thromb Hemost · February 2020 Surgical patients, following procedural interventions or traumatic injury, often bleed due to ongoing blood loss or coagulopathy. Volume resuscitation and transfusion management are critical for the massively bleeding patient. While transfusions may correc ... Full text Link to item Cite

Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician.

Journal article Curr Anesthesiol Rep · 2020 PURPOSE OF REVIEW: This review will illustrate the importance of heparin-induced thrombocytopenia in the intraoperative and critical care settings. RECENT FINDINGS: Heparin-induced thrombocytopenia (HIT) occurs more frequently in surgical patients compared ... Full text Open Access Link to item Cite

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Journal article J Cardiothorac Vasc Anesth · May 2019 The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary f ... Full text Open Access Link to item Cite

Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an algorithmic approach to haemostasis.

Journal article Vox Sang · May 2019 Featured Publication BACKGROUND/OBJECTIVES: Prothrombin complex concentrates (PCC) are increasingly administered off-label in the United States to treat bleeding in cardiovascular surgical patients and carry the potential risk for acquired thromboembolic side-effects after sur ... Full text Open Access Link to item Cite

Renal Angina Is a Sensitive, but Nonspecific Identifier of Postcardiac Surgery Acute Kidney Injury.

Journal article J Cardiothorac Vasc Anesth · February 2019 OBJECTIVES: Acute kidney injury (AKI) is a common complication of cardiac surgery, and early detection is difficult. This study was performed to determine the sensitivity, specificity, positive predictive value, negative predictive value, and statistical p ... Full text Link to item Cite

Heparin-Induced Thrombocytopenia: A Review for Cardiac Anesthesiologists and Intensivists.

Journal article J Cardiothorac Vasc Anesth · February 2019 Patients undergoing cardiovascular surgery may be exposed to heparin before surgery, during cardiopulmonary bypass (CPB), or in the immediate postoperative period. For this reason, cardiovascular surgery patients are at increased risk for heparin-induced t ... Full text Link to item Cite

Aortic Regurgitation in Acute Type-A Aortic Dissection: A Clinical Classification for the Perioperative Echocardiographer in the Era of the Functional Aortic Annulus.

Journal article J Cardiothorac Vasc Anesth · February 2018 The functional aortic annulus offers a clinical approach for the perioperative echocardiographer to classify the mechanisms of aortic regurgitation in acute type-A dissection. Comprehensive examination of the functional aortic annulus in this setting using ... Full text Link to item Cite

Intraoperative vasoplegia: methylene blue to the rescue!

Journal article Curr Opin Anaesthesiol · February 2018 PURPOSE OF REVIEW: To evaluate the efficacy, dosing, and safety of methylene blue (MTB) in perioperative vasoplegic syndrome (VS). RECENT FINDINGS: Vasoplegic syndrome is a state of persistent hypotension with elevated cardiac output, low filling pressures ... Full text Open Access Link to item Cite

Adjuncts to Blood Component Therapies for the Treatment of Bleeding in the Intensive Care Unit.

Journal article Transfus Med Rev · October 2017 Patients who are critically ill following surgical or traumatic injury often present with coagulopathy as a component of the complex multisystem dysfunction that clinicians must rapidly diagnose and treat in the intensive care environment. Failure to recog ... Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

Assessment of Paravalvular Leak After Transcatheter Aortic Valve Replacement: Transesophageal Echocardiography Compared With Transthoracic Echocardiography.

Journal article J Cardiothorac Vasc Anesth · August 2017 OBJECTIVES: Determine whether moderate or greater paravalvular leak (PVL) after transcatheter aortic valve replacement quantified using intraoperative transesophageal echocardiography (TEE) is associated with mortality and investigate the correlation betwe ... Full text Link to item Cite

Perioperative management of the bleeding patient.

Journal article Br J Anaesth · December 2016 Featured Publication Perioperative bleeding remains a major complication during and after surgery, resulting in increased morbidity and mortality. The principal causes of non-vascular sources of haemostatic perioperative bleeding are a preexisting undetected bleeding disorder, ... Full text Open Access Link to item Cite

Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting.

Journal article Anesth Analg · May 2016 Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore deficient coagulation factor co ... Full text Open Access Link to item Cite

Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.

Journal article Can J Anaesth · April 2016 BACKGROUND: We characterized cardiac surgery-induced dynamic changes of the corrected QT (QTc) interval and tested the hypothesis that genetic factors are associated with perioperative QTc prolongation independent of clinical and procedural factors. METHOD ... Full text Open Access Link to item Cite

Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation.

Journal article Expert Rev Hematol · 2016 Andexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity. In ex vivo, animal ... Full text Open Access Link to item Cite

Sodium bicarbonate use and the risk of hypernatremia in thoracic aortic surgical patients with metabolic acidosis following deep hypothermic circulatory arrest.

Journal article Ann Card Anaesth · 2016 OBJECTIVE: Metabolic acidosis after deep hypothermic circulatory arrest (DHCA) for thoracic aortic operations is commonly managed with sodium bicarbonate (NaHCO 3 ). The purpose of this study was to determine the relationships between total NaHCO 3 dose an ... Full text Link to item Cite

Severity and Duration of Metabolic Acidosis After Deep Hypothermic Circulatory Arrest for Thoracic Aortic Surgery.

Journal article J Cardiothorac Vasc Anesth · December 2015 OBJECTIVE: To determine the severity, duration, and contributing factors for metabolic acidosis after deep hypothermic circulatory arrest (DHCA). DESIGN: Retrospective observational study. SETTING: University hospital. PATIENTS: Eighty-seven consecutive pa ... Full text Link to item Cite

Update on perioperative care of the cardiac patient for noncardiac surgery.

Journal article Curr Opin Anaesthesiol · June 2015 PURPOSE OF REVIEW: The current review will address key topics and recommendations of the recent 2014 update of the American College of Cardiology and American Heart Association clinical practice guideline for the perioperative cardiovascular evaluation and ... Full text Link to item Cite

The functional aortic annulus in the 3D era: focus on transcatheter aortic valve replacement for the perioperative echocardiographer.

Journal article J Cardiothorac Vasc Anesth · February 2015 The functional aortic annulus represents a sound clinical framework for understanding the components of the aortic root complex. Recent three-dimensional imaging analysis has demonstrated that the aortic annulus frequently is elliptical rather than circula ... Full text Link to item Cite

Advancing extubation time for cardiac surgery patients using lean work design.

Journal article J Cardiothorac Vasc Anesth · December 2014 Featured Publication BACKGROUND: Early extubation in select cardiac surgery patients reduces tracheal intubation times, intensive care unit length of stay, and hospital length of stay. While there is good evidence in the literature to support early extubation, there is very li ... Full text Link to item Cite

New frontiers in aortic therapy: focus on deep hypothermic circulatory arrest.

Journal article J Cardiothorac Vasc Anesth · August 2014 There is currently a paradigm shift in the conduct of adult aortic arch repair. Although deep hypothermic circulatory arrest has been the classic perfusion platform for adult aortic arch repair, recent developments have challenged this aortic arch paradigm ... Full text Link to item Cite

Incidental moderate mitral regurgitation in patients undergoing coronary artery bypass grafting: update on guidelines and key randomized trials.

Journal article J Cardiothorac Vasc Anesth · February 2014 Incidental moderate mitral regurgitation (MR) in patients presenting for coronary artery bypass grafting (CABG) is not only common but also probably adversely affects clinical outcome. The echocardiographic evaluation of incidental MR must be comprehensive ... Full text Link to item Cite

The year in cardiothoracic and vascular anesthesia: selected highlights from 2013.

Journal article J Cardiothorac Vasc Anesth · February 2014 This article reviewed selected research highlights of 2013 that pertain to the specialty of cardiothoracic and vascular anesthesia. The first major theme is the commemoration of the sixtieth anniversary of the first successful cardiac surgical procedure wi ... Full text Link to item Cite

Major themes for 2013 in cardiothoracic and vascular anaesthesia and intensive care.

Journal article Heart Lung Vessel · 2014 There has been significant progress throughout 2013 in cardiothoracic and vascular anaesthesia and intensive care. There has been a revolution in the medical and interventional management of atrial fibrillation. The medical advances include robust clinical ... Open Access Link to item Cite

Practice variations in the conduct of hypothermic circulatory arrest for adult aortic arch repair: focus on an emerging European paradigm.

Journal article Heart Lung Vessel · 2014 INTRODUCTION: Hypothermic circulatory arrest for adult aortic arch repair is still high-risk. Despite decades of clinical experience, significant practice variations exist around the world. These practice variations in hypothermic circulatory arrest may of ... Open Access Link to item Cite

Perioperative conduction disturbances after transcatheter aortic valve replacement.

Journal article J Cardiothorac Vasc Anesth · December 2013 Cardiac conduction disturbances after transcatheter aortic valve replacement (TAVR) are common and important. The risk factors and outcome effects of atrial fibrillation after TAVR recently have been appreciated. The paucity of clinical trials has resulted ... Full text Link to item Cite

The year in cardiothoracic and vascular anesthesia: selected highlights from 2012.

Journal article J Cardiothorac Vasc Anesth · February 2013 Cardiothoracic and vascular critical care has emerged as a subspecialty due to procedural breakthroughs, an aging population, and a multidisciplinary collaboration. This subspecialty now has a dedicated professional society, recently published guidelines, ... Full text Link to item Cite

Challenges after the first decade of transcatheter aortic valve replacement: focus on vascular complications, stroke, and paravalvular leak.

Journal article J Cardiothorac Vasc Anesth · February 2013 Transcatheter aortic valve replacement (TAVR) is entering its second decade. Three major clinical challenges have emerged from the first decade of experience: vascular complications, stroke, and paravalvular leak (PVL). Major vascular complications remain ... Full text Link to item Cite

Current conduct of deep hypothermic circulatory arrest in China.

Journal article HSR Proc Intensive Care Cardiovasc Anesth · 2013 INTRODUCTION: Deep hypothermic circulatory arrest for adult aortic arch repair is still associated with significant mortality and morbidity. Furthermore, there is still significant variation in the conduct of this complex perioperative technique. This vari ... Open Access Link to item Cite