Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Research Fellowship, Duke Clinical Research Institute, Duke University School of Medicine 2013 - 2015
  • Critical Care Medicine Fellowship, Department Of Pediatrics, Duke University School of Medicine 2012 - 2015
  • Medical Instructor, Department Of Medicine (Internal Med), Duke University School of Medicine 2011 - 2012
  • Medical Instructor/Chief Resident, Department Of Pediatrics, Duke University School of Medicine 2011 - 2012
  • Medicine-Pediatrics Residency Training, Pediatrics, Duke University 2007 - 2011
  • M.D., Duke University School of Medicine 2007
  • M.P.H., University of North Carolina at Chapel Hill 2006
• 

  Duke Appointment History

  • Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2015 - 2019
  • Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2011 - 2013
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Primary Care Pediatrics, Pediatrics 2011 - 2012
• Expertise
• 

  Subject Headings

  • Pediatric intensive care
• Research
• 

  Selected Grants

  • Clinical Outcome Assessments for Pediatric Opioid-Sparing Trials (COA POST) awarded by Food and Drug Administration 2019 - 2024
  • PTN TO: BPCA INNOVATIVE TRIAL DESIGNS FOR DOSING, SAFETY, and EFFICACY in PEDIATRIC THERAPEUTICS 2019 - 2024
  • Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT) awarded by National Institutes of Health 2016 - 2023
  • Duke Summer Training in Academic Research (Duke's STAR) awarded by National Institutes of Health 2018 - 2023
  • PTN2- TO# BPCA Pharmacology Studies 2018 - 2022
  • Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2021
  • Investigating polypharmacy-related adverse events in critically ill children using electronic health records and simulated drug levels awarded by National Institutes of Health 2017 - 2021
  • Prospect of Direct Benefit in Pediatric Reseach in Type 1 Diabetes (T1D) 2018 - 2020
  • PTN TO# Anesthesia awarded by National Institutes of Health 2017 - 2020
  • IMPACCT awarded by Ann & Robert H. Lurie Children's Hospital of Chicago 2019 - 2020
  • UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2016 - 2020
  • Pediatric Trials Network_ Task Order 1_ Core Function Activities Option Period 1 2019 - 2020
  • Oxycontin Drug Utilization in Children 2019
  • UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2017 - 2019
  • Pediatric Trials Network_ Task Order 1_ Core Function Activities 2018 - 2019
  • Duke CTSA (KL2) awarded by National Institutes of Health 2013 - 2018
• 

  Industry Relationships

  • Purdue Pharma L.P.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, David G. Speicher, Janice E. Sullivan, Kevin Watt, Amira Al-Uzri, et al. “Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis..” J Clin Pharmacol, December 8, 2019. https://doi.org/10.1002/jcph.1562.
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    • Ji, Dabin, P Brian Smith, Reese H. Clark, Kanecia O. Zimmerman, Matthew Laughon, Lawrence Ku, and Rachel G. Greenberg. “Wide variation in caffeine discontinuation timing in premature infants..” J Perinatol, November 22, 2019. https://doi.org/10.1038/s41372-019-0561-0.
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    • Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Response to Zhang et al..” Genet Med, November 12, 2019. https://doi.org/10.1038/s41436-019-0690-z.
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    • Miller, Andrew G., Kaitlyn E. Haynes, Rachel M. Gates, Kanecia O. Zimmerman, Travis S. Heath, Kathleen W. Bartlett, Heather S. McLean, and Kyle J. Rehder. “A Respiratory Therapist-Driven Asthma Pathway Reduced Hospital Length of Stay in the Pediatric Intensive Care Unit..” Respir Care 64, no. 11 (November 2019): 1325–32. https://doi.org/10.4187/respcare.06626.
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    • Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants..” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.
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    • Dallefeld, Samantha H., Jennifer Sherwin, Kanecia O. Zimmerman, and Kevin M. Watt. “Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study..” Perfusion, August 21, 2019. https://doi.org/10.1177/0267659119868062.
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    • Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Detection of iron deficiency in children with Down syndrome..” Genet Med, August 16, 2019. https://doi.org/10.1038/s41436-019-0637-4.
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    • Zimmerman, Kanecia O., Daniel K. Benjamin, and Mara L. Becker. “Neonatal Therapeutics: Considerations for Dosing..” Am J Perinatol 36, no. S 02 (July 2019): S18–21. https://doi.org/10.1055/s-0039-1691772.
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    • Tang, Monica, Kanecia O. Zimmerman, and Jason E. Lang. “Severe childhood asthma exacerbations: Is treatment response variability in the genes?.” Pediatr Pulmonol 54, no. 6 (June 2019): 680–82. https://doi.org/10.1002/ppul.24309.
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    • Puia-Dumitrescu, Mihai, Daniel K. Benjamin, P Brian Smith, Rachel G. Greenberg, Nada Abuzaid, Winsome Andrews, Kris Chellani, et al. “Impact of Gastrostomy Tube Placement on Short-Term Weight Gain in Hospitalized Premature Infants..” Jpen J Parenter Enteral Nutr, March 25, 2019. https://doi.org/10.1002/jpen.1539.
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    • Zimmerman, Kanecia O., P Brian Smith, Ann W. McMahon, Jean Temeck, Debbie Avant, Dianne Murphy, and Susan McCune. “Duration of Pediatric Clinical Trials Submitted to the US Food and Drug Administration..” Jama Pediatr 173, no. 1 (January 1, 2019): 60–67. https://doi.org/10.1001/jamapediatrics.2018.3227.
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    • Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants..” Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.
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    • Ge, Shufan, Ryan J. Beechinor, Christoph P. Hornik, Joseph F. Standing, Kanecia Zimmerman, Michael Cohen-Wolkowiez, Matthew M. Laughon, Reese Clark, and Daniel Gonzalez. “External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database..” Antimicrob Agents Chemother 62, no. 9 (September 2018). https://doi.org/10.1128/AAC.00669-18.
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    • Zimmerman, Kanecia O., Huali Wu, Matthew Laughon, Rachel G. Greenberg, Richard Walczak, Scott R. Schulman, P Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass..” Anesth Analg, August 22, 2018. https://doi.org/10.1213/ANE.0000000000003700.
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    • Heath, Travis S., Rachel G. Greenberg, Susan R. Hupp, David A. Turner, Christoph P. Hornik, and Kanecia O. Zimmerman. “Effects of Methadone on Corrected Q-T Interval Prolongation in Critically Ill Children..” J Pediatr Pharmacol Ther 23, no. 2 (March 2018): 119–24. https://doi.org/10.5863/1551-6776-23.2.119.
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    • Patel, Ravi M., Kanecia Zimmerman, David P. Carlton, Reese Clark, Daniel K. Benjamin, and P Brian Smith. “Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants..” J Pediatr 190 (November 2017): 108-111.e1. https://doi.org/10.1016/j.jpeds.2017.07.006.
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    • Dallefeld, Samantha H., Tracy G. Spears, and Kanecia O. Zimmerman. “The Challenges of Identifying an Oxygenation Index Threshold for Increased Mortality in Pediatric Acute Respiratory Failure..” Respir Care 62, no. 10 (October 2017): 1375–76. https://doi.org/10.4187/respcare.05863.
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    • Greenberg, Rachel G., Huali Wu, Matthew Laughon, Edmund Capparelli, Stevie Rowe, Kanecia O. Zimmerman, P Brian Smith, and Michael Cohen-Wolkowiez. “Population Pharmacokinetics of Dexmedetomidine in Infants..” J Clin Pharmacol 57, no. 9 (September 2017): 1174–82. https://doi.org/10.1002/jcph.904.
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    • Ericson, Jessica E., Kanecia O. Zimmerman, Daniel Gonzalez, Chiara Melloni, Jeffrey T. Guptill, Kevin D. Hill, Huali Wu, and Michael Cohen-Wolkowiez. “A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation..” Ther Drug Monit 39, no. 1 (February 2017): 13–20. https://doi.org/10.1097/FTD.0000000000000364.
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    • Ku, Lawrence C., Kanecia Zimmerman, Daniel K. Benjamin, Reese H. Clark, Christoph P. Hornik, P Brian Smith, and P Brian Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Safety of Enalapril in Infants Admitted to the Neonatal Intensive Care Unit..” Pediatr Cardiol 38, no. 1 (January 2017): 155–61. https://doi.org/10.1007/s00246-016-1496-2.
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    • Zimmerman, Kanecia O., P Brian Smith, Daniel K. Benjamin, Matthew Laughon, Reese Clark, Chani Traube, Til Stürmer, and Christoph P. Hornik. “Sedation, Analgesia, and Paralysis during Mechanical Ventilation of Premature Infants..” J Pediatr 180 (January 2017): 99-104.e1. https://doi.org/10.1016/j.jpeds.2016.07.001.
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    • Zimmerman, Kanecia O., Huali Wu, Rachel Greenberg, Jeffrey T. Guptill, Kevin Hill, Uptal D. Patel, Lawrence Ku, et al. “Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients..” Ther Drug Monit 38, no. 5 (October 2016): 600–606. https://doi.org/10.1097/FTD.0000000000000313.
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    • Zimmerman, Kanecia, Martin Putera, Christoph P. Hornik, P. Brian Smith, Daniel K. Benjamin, Yeruk Mulugeta, Gilbert J. Burckart, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval..” Clin Ther 38, no. 9 (September 2016): 1995–2005. https://doi.org/10.1016/j.clinthera.2016.06.003.
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    • Zimmerman, Kanecia, Daniel Gonzalez, Geeta K. Swamy, and Michael Cohen-Wolkowiez. “Pharmacologic studies in vulnerable populations: Using the pediatric experience..” Semin Perinatol 39, no. 7 (November 2015): 532–36. https://doi.org/10.1053/j.semperi.2015.08.007.
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    • Rehder, Kyle J., Elizabeth A. Wilson, Kanecia O. Zimmerman, Coleen K. Cunningham, and David A. Turner. “Detection of Multiple Respiratory Viruses Associated With Mortality and Severity of Illness in Children..” Pediatr Crit Care Med 16, no. 7 (September 2015): e201–6. https://doi.org/10.1097/PCC.0000000000000492.
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    • Zimmerman, Kanecia O., Christoph P. Hornik, Lawrence Ku, Kevin Watt, Matthew M. Laughon, Margarita Bidegain, Reese H. Clark, and P Brian Smith. “Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life..” J Pediatr 167, no. 2 (August 2015): 299-304.e3. https://doi.org/10.1016/j.jpeds.2015.04.059.
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    • Johnson, David P., Kanecia Zimmerman, Betty Staples, Kathleen A. McGann, Karen Frush, and David A. Turner. “Multicenter development, implementation, and patient safety impacts of a simulation-based module to teach handovers to pediatric residents..” Hosp Pediatr 5, no. 3 (March 2015): 154–59. https://doi.org/10.1542/hpeds.2014-0050.
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    • Gonzalez, Daniel, Chiara Melloni, Brenda B. Poindexter, Ram Yogev, Andrew M. Atz, Janice E. Sullivan, Susan R. Mendley, et al. “Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots..” Bioanalysis 7, no. 9 (2015): 1137–49. https://doi.org/10.4155/bio.15.38.
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    • Anderson, Anna W., P Brian Smith, Kristin M. Corey, Kevin D. Hill, Kanecia O. Zimmerman, Reese H. Clark, and Christoph P. Hornik. “Clinical outcomes in very low birth weight infants with major congenital heart defects..” Early Hum Dev 90, no. 12 (December 2014): 791–95. https://doi.org/10.1016/j.earlhumdev.2014.09.006.
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    • Zimmerman, Kanecia O., Susan R. Hupp, Ali Bourguet-Vincent, Erin A. Bressler, Eileen M. Raynor, David A. Turner, and Kyle J. Rehder. “Acute upper-airway obstruction by a lingual thyroglossal duct cyst and implications for advanced airway management..” Respir Care 59, no. 7 (July 2014): e98–102. https://doi.org/10.4187/respcare.02513.
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    • Zimmerman, K. O., and P. B. Smith. “Current epidemiology and management of invasive candidiasis in infants.” Current Fungal Infection Reports 8, no. 1 (January 1, 2014): 1–11. https://doi.org/10.1007/s12281-013-0167-5.
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    • Zimmerman, K. O., and P. B. Smith. “Erratum to Current Epidemiology and Management of Invasive Candidiasis in Infants [Current Fungal Infection Reports(2014), 8,1-11, 10.1007/s12281-013-0167-5].” Current Fungal Infection Reports 8, no. 3 (January 1, 2014). https://doi.org/10.1007/s12281-014-0187-9.
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  • Book Sections

    • Zimmerman, K., and D. K. Benjamin. “Necrotizing Enterocolitis.” In Principles and Practice of Pediatric Infectious Diseases, 394-397.e2, 2018. https://doi.org/10.1016/B978-0-323-40181-4.00058-X.
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