Kanecia Obie Zimmerman | Scholars@Duke

Kanecia Obie Zimmerman
Associate Professor of Pediatrics

Current Research Interests

Pharmacoepidemiology
Clinical Pharmacology
Drug Safety in Pediatric Critical Illness

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2019
Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2015

Contact Information

2400 Pratt Street, Durham, NC 27710
kanecia.zimmerman@duke.edu (919) 668-8651

Background
Education, Training, & Certifications
- Clinical Research Fellowship, Duke Clinical Research Institute, Duke University School of Medicine 2013 - 2015
- Critical Care Medicine Fellowship, Department Of Pediatrics, Duke University School of Medicine 2012 - 2015
- Medical Instructor, Department Of Medicine (Internal Med), Duke University School of Medicine 2011 - 2012
- Medical Instructor/Chief Resident, Department Of Pediatrics, Duke University School of Medicine 2011 - 2012
- Medicine-Pediatrics Residency Training, Pediatrics, Duke University 2007 - 2011
- M.D., Duke University School of Medicine 2007
- M.P.H., University of North Carolina - Chapel Hill 2006
Duke Appointment History
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2015 - 2019
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2011 - 2013
- Medical Instructor in the Department of Pediatrics, Pediatrics, Primary Care Pediatrics, Pediatrics 2011 - 2012
Expertise
Subject Headings
- Pediatric intensive care
Research
Selected Grants
- Overcoming barriers to addressing childhood opioid exposure: Developing Standard Clinical Outcome Assessments for Pediatric Trials of Opioid-Sparing Drugs for Acute Pain awarded by Food and Drug Administration 2019 - 2024
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- PTN TO: BPCA INNOVATIVE TRIAL DESIGNS FOR DOSING, SAFETY, and EFFICACY in PEDIATRIC THERAPEUTICS 2019 - 2024
- Duke Summer Training in Academic Research (Duke's STAR) awarded by National Institutes of Health 2018 - 2023
- PTN2- TO# BPCA Pharmacology Studies 2018 - 2022
- Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2021
- Investigating polypharmacy-related adverse events in critically ill children using electronic health records and simulated drug levels awarded by National Institutes of Health 2017 - 2021
- Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT) awarded by National Institutes of Health 2016 - 2021
- PTN 2.0 TO 1 Core Function Activities_Option 2 2020 - 2021
- Pediatric Critical Care Research Landscape - A National Expert Conference awarded by National Institutes of Health 2020 - 2021
- Prospect of Direct Benefit in Pediatric Reseach in Type 1 Diabetes (T1D) 2018 - 2020
- PTN TO# Anesthesia awarded by National Institutes of Health 2017 - 2020
- IMPACCT awarded by Ann & Robert H. Lurie Children's Hospital of Chicago 2019 - 2020
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2016 - 2020
- Pediatric Trials Network_ Task Order 1_ Core Function Activities Option Period 1 2019 - 2020
- Oxycontin Drug Utilization in Children 2019
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2017 - 2019
- Pediatric Trials Network_ Task Order 1_ Core Function Activities 2018 - 2019
- Duke CTSA (KL2) awarded by National Institutes of Health 2013 - 2018
External Relationships
- Purdue Pharma L.P.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gray, Keyaria D., Julia A. Messina, Christopher Cortina, Tanasha Owens, Madeline Fowler, Matthew Foster, Simi Gbadegesin, et al. “Probiotic Use and Safety in the Neonatal Intensive Care Unit: A Matched Cohort Study.” J Pediatr 222 (July 2020): 59-64.e1. https://doi.org/10.1016/j.jpeds.2020.03.051.
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  - Wolf, Mattie F., Julie Childers, Keyaria D. Gray, Caroline Chivily, Mike Glenn, Laila Jones, Mini Kpa, et al. “Authors' response to thrombocytopenia following exchange transfusion in neonates.” J Perinatol 40, no. 7 (July 2020): 1119. https://doi.org/10.1038/s41372-020-0687-0.
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  - Scott, Briana L., Chi D. Hornik, and Kanecia O. Zimmerman. “Pharmacokinetic, efficacy, and safety considerations for the use of antifungal drugs in the neonatal population.” Expert Opin Drug Metab Toxicol, June 7, 2020, 1–12. https://doi.org/10.1080/17425255.2020.1773793.
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  - Maharaj, Anil R., Huali Wu, Christoph P. Hornik, Stephen J. Balevic, Chi D. Hornik, P Brian Smith, Daniel Gonzalez, et al. “Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.” Jama Pediatr, June 5, 2020, e202422. https://doi.org/10.1001/jamapediatrics.2020.2422.
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  - Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, Julie Autmizguine, Rohit Kalra, Amira Al-Uzri, Catherine M. T. Sherwin, et al. “Population pharmacokinetics of olanzapine in children.” Br J Clin Pharmacol, June 4, 2020. https://doi.org/10.1111/bcp.14414.
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  - Donoghue, Aaron J., Maybelle Kou, Grace L. Good, Carmel Eiger, Mark Nash, Fred M. Henretig, Helen Stacks, et al. “Impact of Personal Protective Equipment on Pediatric Cardiopulmonary Resuscitation Performance: A Controlled Trial.” Pediatr Emerg Care 36, no. 6 (June 2020): 267–73. https://doi.org/10.1097/PEC.0000000000002109.
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  - Funk, Ryan S., Nasreen J. Talib, Kanecia O. Zimmerman, Leon van Haandel, and Mara L. Becker. “Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.” J Pediatr 221 (June 2020): 235–39. https://doi.org/10.1016/j.jpeds.2020.01.032.
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  - Khan, Aleena A., Laura E. Case, Mrudu Herbert, Stephanie DeArmey, Harrison Jones, Kelly Crisp, Kanecia Zimmerman, Mai K. ElMallah, Sarah P. Young, and Priya S. Kishnani. “Higher dosing of alglucosidase alfa improves outcomes in children with Pompe disease: a clinical study and review of the literature.” Genet Med 22, no. 5 (May 2020): 898–907. https://doi.org/10.1038/s41436-019-0738-0.
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  - Dallefeld, Samantha H., Jennifer Sherwin, Kanecia O. Zimmerman, and Kevin M. Watt. “Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study.” Perfusion 35, no. 3 (April 2020): 209–16. https://doi.org/10.1177/0267659119868062.
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  - Wolf, Mattie F., Julie Childers, Keyaria D. Gray, Caroline Chivily, Mike Glenn, Laila Jones, Mini Kpa, et al. “Exchange transfusion safety and outcomes in neonatal hyperbilirubinemia.” J Perinatol, March 9, 2020. https://doi.org/10.1038/s41372-020-0642-0.
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  - Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Response to Zhang et al.” Genet Med 22, no. 3 (March 2020): 662. https://doi.org/10.1038/s41436-019-0690-z.
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  - Jackson, Wesley, Genevieve Taylor, Nicolas A. Bamat, Kanecia Zimmerman, Reese Clark, Daniel K. Benjamin, Matthew M. Laughon, Rachel G. Greenberg, and Christoph P. Hornik. “Outcomes associated with surfactant in more mature and larger premature infants with respiratory distress syndrome.” J Perinatol, February 20, 2020. https://doi.org/10.1038/s41372-020-0625-1.
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  - Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Detection of iron deficiency in children with Down syndrome.” Genet Med 22, no. 2 (February 2020): 317–25. https://doi.org/10.1038/s41436-019-0637-4.
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  - Ji, Dabin, P Brian Smith, Reese H. Clark, Kanecia O. Zimmerman, Matthew Laughon, Lawrence Ku, and Rachel G. Greenberg. “Wide variation in caffeine discontinuation timing in premature infants.” J Perinatol 40, no. 2 (February 2020): 288–93. https://doi.org/10.1038/s41372-019-0561-0.
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  - Puia-Dumitrescu, Mihai, Daniel K. Benjamin, P Brian Smith, Rachel G. Greenberg, Nada Abuzaid, Winsome Andrews, Kris Chellani, et al. “Impact of Gastrostomy Tube Placement on Short-Term Weight Gain in Hospitalized Premature Infants.” Jpen J Parenter Enteral Nutr 44, no. 2 (February 2020): 355–60. https://doi.org/10.1002/jpen.1539.
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  - Dallefeld, S. H., P. B. Smith, E. G. Crenshaw, K. R. Daniel, M. L. Gilleskie, D. S. Smith, S. Balevic, et al. “Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants.” J Neonatal Perinatal Med 13, no. 2 (2020): 159–65. https://doi.org/10.3233/NPM-190214.
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  - Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, David G. Speicher, Janice E. Sullivan, Kevin Watt, Amira Al-Uzri, et al. “Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis.” J Clin Pharmacol, December 8, 2019. https://doi.org/10.1002/jcph.1562.
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  - Zimmerman, Kanecia O., Huali Wu, Matthew Laughon, Rachel G. Greenberg, Richard Walczak, Scott R. Schulman, P Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.” Anesth Analg 129, no. 6 (December 2019): 1519–28. https://doi.org/10.1213/ANE.0000000000003700.
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  - Miller, Andrew G., Kaitlyn E. Haynes, Rachel M. Gates, Kanecia O. Zimmerman, Travis S. Heath, Kathleen W. Bartlett, Heather S. McLean, and Kyle J. Rehder. “A Respiratory Therapist-Driven Asthma Pathway Reduced Hospital Length of Stay in the Pediatric Intensive Care Unit.” Respir Care 64, no. 11 (November 2019): 1325–32. https://doi.org/10.4187/respcare.06626.
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  - Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants.” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.
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  - Zimmerman, Kanecia O., Daniel K. Benjamin, and Mara L. Becker. “Neonatal Therapeutics: Considerations for Dosing.” Am J Perinatol 36, no. S 02 (July 2019): S18–21. https://doi.org/10.1055/s-0039-1691772.
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  - Tang, Monica, Kanecia O. Zimmerman, and Jason E. Lang. “Severe childhood asthma exacerbations: Is treatment response variability in the genes?” Pediatr Pulmonol 54, no. 6 (June 2019): 680–82. https://doi.org/10.1002/ppul.24309.
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  - Zimmerman, Kanecia O., P Brian Smith, Ann W. McMahon, Jean Temeck, Debbie Avant, Dianne Murphy, and Susan McCune. “Duration of Pediatric Clinical Trials Submitted to the US Food and Drug Administration.” Jama Pediatr 173, no. 1 (January 1, 2019): 60–67. https://doi.org/10.1001/jamapediatrics.2018.3227.
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  - Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.” Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.
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  - Ge, Shufan, Ryan J. Beechinor, Christoph P. Hornik, Joseph F. Standing, Kanecia Zimmerman, Michael Cohen-Wolkowiez, Matthew M. Laughon, Reese Clark, and Daniel Gonzalez. “External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.” Antimicrob Agents Chemother 62, no. 9 (September 2018). https://doi.org/10.1128/AAC.00669-18.
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  - Heath, Travis S., Rachel G. Greenberg, Susan R. Hupp, David A. Turner, Christoph P. Hornik, and Kanecia O. Zimmerman. “Effects of Methadone on Corrected Q-T Interval Prolongation in Critically Ill Children.” J Pediatr Pharmacol Ther 23, no. 2 (March 2018): 119–24. https://doi.org/10.5863/1551-6776-23.2.119.
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  - Patel, Ravi M., Kanecia Zimmerman, David P. Carlton, Reese Clark, Daniel K. Benjamin, and P Brian Smith. “Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants.” J Pediatr 190 (November 2017): 108-111.e1. https://doi.org/10.1016/j.jpeds.2017.07.006.
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  - Dallefeld, Samantha H., Tracy G. Spears, and Kanecia O. Zimmerman. “The Challenges of Identifying an Oxygenation Index Threshold for Increased Mortality in Pediatric Acute Respiratory Failure.” Respir Care 62, no. 10 (October 2017): 1375–76. https://doi.org/10.4187/respcare.05863.
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  - Greenberg, Rachel G., Huali Wu, Matthew Laughon, Edmund Capparelli, Stevie Rowe, Kanecia O. Zimmerman, P Brian Smith, and Michael Cohen-Wolkowiez. “Population Pharmacokinetics of Dexmedetomidine in Infants.” J Clin Pharmacol 57, no. 9 (September 2017): 1174–82. https://doi.org/10.1002/jcph.904.
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  - Ericson, Jessica E., Kanecia O. Zimmerman, Daniel Gonzalez, Chiara Melloni, Jeffrey T. Guptill, Kevin D. Hill, Huali Wu, and Michael Cohen-Wolkowiez. “A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.” Ther Drug Monit 39, no. 1 (February 2017): 13–20. https://doi.org/10.1097/FTD.0000000000000364.
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  - Ku, Lawrence C., Kanecia Zimmerman, Daniel K. Benjamin, Reese H. Clark, Christoph P. Hornik, P Brian Smith, and P Brian Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Safety of Enalapril in Infants Admitted to the Neonatal Intensive Care Unit.” Pediatr Cardiol 38, no. 1 (January 2017): 155–61. https://doi.org/10.1007/s00246-016-1496-2.
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  - Zimmerman, Kanecia O., P Brian Smith, Daniel K. Benjamin, Matthew Laughon, Reese Clark, Chani Traube, Til Stürmer, and Christoph P. Hornik. “Sedation, Analgesia, and Paralysis during Mechanical Ventilation of Premature Infants.” J Pediatr 180 (January 2017): 99-104.e1. https://doi.org/10.1016/j.jpeds.2016.07.001.
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  - Zimmerman, Kanecia O., Huali Wu, Rachel Greenberg, Jeffrey T. Guptill, Kevin Hill, Uptal D. Patel, Lawrence Ku, et al. “Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients.” Ther Drug Monit 38, no. 5 (October 2016): 600–606. https://doi.org/10.1097/FTD.0000000000000313.
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  - Zimmerman, Kanecia, Martin Putera, Christoph P. Hornik, P. Brian Smith, Daniel K. Benjamin, Yeruk Mulugeta, Gilbert J. Burckart, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval.” Clin Ther 38, no. 9 (September 2016): 1995–2005. https://doi.org/10.1016/j.clinthera.2016.06.003.
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  - Zimmerman, Kanecia, Daniel Gonzalez, Geeta K. Swamy, and Michael Cohen-Wolkowiez. “Pharmacologic studies in vulnerable populations: Using the pediatric experience.” Semin Perinatol 39, no. 7 (November 2015): 532–36. https://doi.org/10.1053/j.semperi.2015.08.007.
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  - Rehder, Kyle J., Elizabeth A. Wilson, Kanecia O. Zimmerman, Coleen K. Cunningham, and David A. Turner. “Detection of Multiple Respiratory Viruses Associated With Mortality and Severity of Illness in Children.” Pediatr Crit Care Med 16, no. 7 (September 2015): e201–6. https://doi.org/10.1097/PCC.0000000000000492.
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  - Zimmerman, Kanecia O., Christoph P. Hornik, Lawrence Ku, Kevin Watt, Matthew M. Laughon, Margarita Bidegain, Reese H. Clark, and P Brian Smith. “Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life.” J Pediatr 167, no. 2 (August 2015): 299-304.e3. https://doi.org/10.1016/j.jpeds.2015.04.059.
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  - Johnson, David P., Kanecia Zimmerman, Betty Staples, Kathleen A. McGann, Karen Frush, and David A. Turner. “Multicenter development, implementation, and patient safety impacts of a simulation-based module to teach handovers to pediatric residents.” Hosp Pediatr 5, no. 3 (March 2015): 154–59. https://doi.org/10.1542/hpeds.2014-0050.
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  - Gonzalez, Daniel, Chiara Melloni, Brenda B. Poindexter, Ram Yogev, Andrew M. Atz, Janice E. Sullivan, Susan R. Mendley, et al. “Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots.” Bioanalysis 7, no. 9 (2015): 1137–49. https://doi.org/10.4155/bio.15.38.
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  - Anderson, Anna W., P Brian Smith, Kristin M. Corey, Kevin D. Hill, Kanecia O. Zimmerman, Reese H. Clark, and Christoph P. Hornik. “Clinical outcomes in very low birth weight infants with major congenital heart defects.” Early Hum Dev 90, no. 12 (December 2014): 791–95. https://doi.org/10.1016/j.earlhumdev.2014.09.006.
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  - Zimmerman, Kanecia O., Susan R. Hupp, Ali Bourguet-Vincent, Erin A. Bressler, Eileen M. Raynor, David A. Turner, and Kyle J. Rehder. “Acute upper-airway obstruction by a lingual thyroglossal duct cyst and implications for advanced airway management.” Respir Care 59, no. 7 (July 2014): e98–102. https://doi.org/10.4187/respcare.02513.
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  - Zimmerman, K. O., and P. B. Smith. “Current epidemiology and management of invasive candidiasis in infants.” Current Fungal Infection Reports 8, no. 1 (January 1, 2014): 1–11. https://doi.org/10.1007/s12281-013-0167-5.
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  - Zimmerman, K. O., and P. B. Smith. “Erratum to Current Epidemiology and Management of Invasive Candidiasis in Infants [Current Fungal Infection Reports(2014), 8,1-11, 10.1007/s12281-013-0167-5].” Current Fungal Infection Reports 8, no. 3 (January 1, 2014). https://doi.org/10.1007/s12281-014-0187-9.
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- Book Sections
  - Zimmerman, K., and D. K. Benjamin. “Necrotizing Enterocolitis.” In Principles and Practice of Pediatric Infectious Diseases, 394-397.e2, 2018. https://doi.org/10.1016/B978-0-323-40181-4.00058-X.
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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections