Kanecia Obie Zimmerman
Associate Professor of Pediatrics
Current Research Interests
Pharmacoepidemiology
Clinical Pharmacology
Drug Safety in Pediatric Critical Illness
Clinical Pharmacology
Drug Safety in Pediatric Critical Illness
Current Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2021
- Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2015
Contact Information
- 2400 Pratt Street, Durham, NC 27710
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kanecia.zimmerman@duke.edu
(919) 668-8651
- Background
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Education, Training, & Certifications
- Clinical Research Fellowship, Duke Clinical Research Institute, Duke University School of Medicine 2013 - 2015
- Critical Care Medicine Fellowship, Department Of Pediatrics, Duke University School of Medicine 2012 - 2015
- Medical Instructor, Department Of Medicine (Internal Med), Duke University School of Medicine 2011 - 2012
- Medical Instructor/Chief Resident, Department Of Pediatrics, Duke University School of Medicine 2011 - 2012
- Medicine-Pediatrics Residency Training, Pediatrics, Duke University 2007 - 2011
- M.D., Duke University School of Medicine 2007
- M.P.H., University of North Carolina - Chapel Hill 2006
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Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2019 - 2021
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2015 - 2019
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2011 - 2013
- Medical Instructor in the Department of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 2011 - 2012
- Recognition
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In the News
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SEP 16, 2022 School of Medicine Magnify -
AUG 2, 2022 Duke Health News -
MAR 10, 2022 Duke Health News -
OCT 8, 2021 Duke Health News -
JUN 30, 2021 Duke Health News -
JUN 30, 2021 -
FEB 11, 2021 School of Medicine Magnify -
JAN 27, 2021
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- Expertise
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Subject Headings
- Research
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Selected Grants
- Infrastructure for Musculoskeletal Pediatric Acute Care Clinical Trials (IMPACCT) awarded by Ann & Robert H Lurie Children's Hospital of Chicago 2021 - 2026
- 2/2 Kids MoD PAH Trial: Mono- vs. Duo-Therapy for Pediatric Pulmonary Arterial Hypertension-DCC awarded by National Institutes of Health 2021 - 2026
- PTN LAP01 Registry awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2021 - 2025
- PTN 2.0 TO 5 Modification awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- PTN TO: BPCA INNOVATIVE TRIAL DESIGNS FOR DOSING, SAFETY, and EFFICACY in PEDIATRIC THERAPEUTICS awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- PTN 2.0 TO #11: CUDDLE 2.0 awarded by National Institutes of Health 2021 - 2024
- Clinical Outcome Assessments for Acute Pain Therapeutics in Infants and your Children (COA APTIC) awarded by Food and Drug Administration 2019 - 2024
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- Duke Summer Training in Academic Research (Duke's STAR) awarded by National Institutes of Health 2018 - 2024
- Optimizing caffeine exposure to reduce post-cardiopulmonary bypass acute kidney injury in neonates awarded by Thrasher Research Fund 2022 - 2023
- Duke Summer Training in Academic Research (Duke's STAR) BIOGEN awarded by Biogen Foundation 2021 - 2023
- PTN TO# Anesthesia awarded by National Institutes of Health 2017 - 2023
- PTN 2.0 Task Order 7 HIV Lactation awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2023
- PTN Task Order 8 COVID-19 Studies awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2023
- Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT) awarded by National Institutes of Health 2016 - 2023
- PTN 2.0 TO1 Core Function Activities - Option 4 awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2022 - 2023
- RECOVER Infrastructure awarded by National Institutes of Health 2022 - 2023
- Duke Summer Training in Academic Research (Duke's STAR) BIOGEN awarded by Biogen Foundation 2022 - 2023
- Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2022
- Pediatric Critical Care Research Landscape - A National Expert Conference awarded by National Institutes of Health 2020 - 2022
- PTN2- TO# BPCA Pharmacology Studies awarded by National Institute for Child Health & Human Develo 2018 - 2022
- PTN TO48 - Pharmacokinetics of Anesthetics and Analgesics in Children and Adolescents Extension awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2022
- PTN 2.0 TO 1 Core Function Activities_Option 3.1 awarded by National Institutes of Health 2021 - 2022
- Investigating polypharmacy-related adverse events in critically ill children using electronic health records and simulated drug levels awarded by National Institutes of Health 2017 - 2021
- IMPACCT awarded by Ann & Robert H Lurie Children's Hospital of Chicago 2019 - 2021
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2020 - 2021
- PTN 2.0 TO 1 Core Function Activities_Option 2 awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2021
- Prospect of Direct Benefit in Pediatric Reseach in Type 1 Diabetes (T1D) awarded by Juvenile Diabetes Research Foundation 2018 - 2021
- Pediatric Trials Network_ Task Order 1_ Core Function Activities Option Period 1 awarded by National Institute for Child Health & Human Develo 2019 - 2020
- Oxycontin Drug Utilization in Children awarded by Purdue Pharma 2019
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2017 - 2019
- Pediatric Trials Network_ Task Order 1_ Core Function Activities awarded by National Institute for Child Health & Human Develo 2018 - 2019
- Duke CTSA (KL2) awarded by National Institutes of Health 2013 - 2018
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Gerhart, Jacqueline G., Fernando O. Carreño, Matthew Shane Loop, Craig R. Lee, Andrea N. Edginton, Jaydeep Sinha, Karan R. Kumar, et al. “Use of Real-World Data and Physiologically-Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children With Obesity.” Clin Pharmacol Ther 112, no. 2 (August 2022): 391–403. https://doi.org/10.1002/cpt.2618.Full Text Link to Item
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Le, Jennifer, Rachel G. Greenberg, YoungJun Yoo, Reese H. Clark, Daniel K. Benjamin, Kanecia O. Zimmerman, Michael Cohen-Wolkowiez, Kelly C. Wade, and Kelly C. Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship.” J Perinatol 42, no. 7 (July 2022): 959–64. https://doi.org/10.1038/s41372-022-01344-2.Full Text Link to Item
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McLaughlin, Matthew J., Eric Caliendo, Ryan Lowder, William D. Watson, Brad Kurowski, Katherine T. Baum, Laura S. Blackwell, et al. “Prescribing Patterns of Amantadine During Pediatric Inpatient Rehabilitation After Traumatic Brain Injury: A Multicentered Retrospective Review From the Pediatric Brain Injury Consortium.” J Head Trauma Rehabil 37, no. 4 (July 2022): 240–48. https://doi.org/10.1097/HTR.0000000000000709.Full Text Link to Item
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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Moira Inkelas, M Alan Brookhart, Daniel K. Benjamin, Sabrina Butteris, Shawn Koval, et al. “School Masking Policies and Secondary SARS-CoV-2 Transmission.” Pediatrics 149, no. 6 (June 1, 2022). https://doi.org/10.1542/peds.2022-056687.Full Text Link to Item
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Gerhart, Jacqueline G., Fernando O. Carreño, Jennifer L. Ford, Andrea N. Edginton, Eliana M. Perrin, Kevin M. Watt, William J. Muller, et al. “Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity.” Cpt Pharmacometrics Syst Pharmacol 11, no. 6 (June 2022): 778–91. https://doi.org/10.1002/psp4.12793.Full Text Link to Item
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Kumar, Karan R., Antonina Flair, Elizabeth J. Thompson, Kanecia O. Zimmerman, Nicholas D. Andersen, Kevin D. Hill, and Christoph P. Hornik. “Association Between Digoxin Use and Cardiac Function in Infants With Single-Ventricle Congenital Heart Disease During the Interstage Period.” Pediatr Crit Care Med 23, no. 6 (June 1, 2022): 453–63. https://doi.org/10.1097/PCC.0000000000002946.Full Text Link to Item
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Zimmerman, Kanecia O., Brian Perry, Emily Hanlen-Rosado, Adora Nsonwu, Morgan D. Lane, Daniel K. Benjamin, Mara Becker, Amy Corneli, and Amy Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Developing lay summaries and thank you notes in paediatric pragmatic clinical trials.” Health Expect 25, no. 3 (June 2022): 1029–37. https://doi.org/10.1111/hex.13448.Full Text Link to Item
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Campbell, Melissa M., Daniel K. Benjamin, Tara Mann, Alex Fist, Hwasoon Kim, Laura Edwards, Zsolt Rak, et al. “Test-to-Stay After Exposure to SARS-CoV-2 in K-12 Schools.” Pediatrics 149, no. 5 (May 1, 2022). https://doi.org/10.1542/peds.2021-056045.Full Text Link to Item
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Job, Kathleen M., André Dallmann, Samuel Parry, George Saade, David M. Haas, Brenna Hughes, Pamela Berens, et al. “Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.” Clin Pharmacol Ther 111, no. 5 (May 2022): 1111–20. https://doi.org/10.1002/cpt.2530.Full Text Link to Item
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Thakkar, Pavan V., Kanecia O. Zimmerman, Daniel K. Benjamin, and Ibukunoluwa C. Kalu. “SARS-CoV-2 Infections and Incidence at a North Carolina Pre-Kindergarten-12 School During In-Person Education: August 2020 to January 2021.” J Sch Health 92, no. 5 (May 2022): 461–68. https://doi.org/10.1111/josh.13148.Full Text Link to Item
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Thakkar, Pavan V., Kanecia O. Zimmerman, M Alan Brookhart, Tyler R. Erickson, Daniel K. Benjamin, Ibukunoluwa C. Kalu, and Ibukunoluwa C. ABC Science Collaborative. “COVID-19 Incidence Among Sixth Through Twelfth Grade Students by Vaccination Status.” Pediatrics 149, no. 5 (May 1, 2022). https://doi.org/10.1542/peds.2022-056230.Full Text Link to Item
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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Daniel K. Benjamin, Gregory P. DeMuri, Ibukunoluwa C. Kalu, Michael J. Smith, Kathleen A. McGann, Shawn Koval, M Alan Brookhart, and Sabrina M. Butteris. “Secondary Transmission of COVID-19 in K-12 Schools: Findings From 2 States.” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268K.Full Text Link to Item
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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Daniel K. Benjamin, Kevin J. Chick, Jake Curtiss, and Tracy Beth Høeg. “Quarantine Elimination for K-12 Students With Mask-on-Mask Exposure to SARS-CoV-2.” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268L.Full Text Link to Item
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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Tara K. Mann, Ganga S. Moorthy, Ashley Blakemore, Kathleen A. McGann, Michael J. Smith, et al. “A School-Based SARS-CoV-2 Testing Program: Testing Uptake and Quarantine Length After In-School Exposures.” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268J.Full Text Link to Item
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Gerhart, Jacqueline G., Fernando O. Carreño, Andrea N. Edginton, Jaydeep Sinha, Eliana M. Perrin, Karan R. Kumar, Aruna Rikhi, et al. “Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.” Clin Pharmacokinet 61, no. 2 (February 2022): 307–20. https://doi.org/10.1007/s40262-021-01072-4.Full Text Link to Item
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Goldman, Jennifer L., Jennifer E. Schuster, Vanessa F. Maier, Rohit Anand, Elizabeth E. Hill, Sabrina M. Butteris, Gregory P. DeMuri, et al. “Urban Classification, Not COVID-19 Community Rates, Was Associated With Modes of Learning in US K-12 Schools?” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268M.Full Text Link to Item
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Moorthy, Ganga S., Tara K. Mann, Angelique E. Boutzoukas, Ashley Blakemore, M Alan Brookhart, Laura Edwards, Jennifer G. Jackman, et al. “Masking Adherence in K-12 Schools and SARS-CoV-2 Secondary Transmission.” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268I.Full Text Link to Item
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Zimmerman, Kanecia O., Jennifer G. Jackman, and Daniel K. Benjamin. “From Research to Policy: Reopening K-12 Schools in North Carolina During the COVID-19 Pandemic.” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268E.Full Text Link to Item
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Zimmerman, Kanecia O., Jennifer L. Goldman, Jennifer E. Schuster, Atenas Mena, Margo Quiriconi, Sabrina M. Butteris, Shawn Koval, et al. “Building a National Framework to Pair Scientists and Schools During a Global Pandemic.” Pediatrics 149, no. Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268D.Full Text Link to Item
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Knight, Lisa, Barbara A. Pahud, Margaret Scheffler, Joshua C. Euteneuer, Christine Allen, Judith Ross, Wail Ali, et al. “Capacity Building in a New Clinical Trials Network through Inter-Network Collaboration.” J Pediatr 240 (January 2022): 5–8. https://doi.org/10.1016/j.jpeds.2021.04.062.Full Text Link to Item
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Stark, Ashley, P Brian Smith, Christoph P. Hornik, Kanecia O. Zimmerman, Chi D. Hornik, Sidart Pradeep, Reese H. Clark, Daniel K. Benjamin, Matthew Laughon, and Rachel G. Greenberg. “Medication Use in the Neonatal Intensive Care Unit and Changes from 2010 to 2018.” J Pediatr 240 (January 2022): 66-71.e4. https://doi.org/10.1016/j.jpeds.2021.08.075.Full Text Link to Item
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Lane, Morgan D., Sujata Kishnani, Obianuju Udemadu, Samuel Eshun Danquah, Robert M. Treadway, Aaliyah Langman, Stephen Balevic, et al. “Comparative efficacy and safety of late surfactant preparations: a retrospective study.” J Perinatol 41, no. 11 (November 2021): 2639–44. https://doi.org/10.1038/s41372-021-01142-2.Full Text Link to Item
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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Daniel K. Benjamin, and Daniel K. ABC Science Collaborative. “School Safety, Masking, and the Delta Variant.” Pediatrics, October 8, 2021. https://doi.org/10.1542/peds.2021-054396.Full Text Link to Item
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Zimmerman, Kanecia O., M Alan Brookhart, Ibukunoluwa C. Kalu, Angelique E. Boutzoukas, Kathleen A. McGann, Michael J. Smith, Gabriela M. Maradiaga Panayotti, et al. “Community SARS-CoV-2 Surge and Within-School Transmission.” Pediatrics 148, no. 4 (October 2021). https://doi.org/10.1542/peds.2021-052686.Full Text Link to Item
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Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, William J. Muller, Janice E. Sullivan, Catherine M. T. Sherwin, Julie Autmizguine, et al. “Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity.” Paediatr Drugs 23, no. 5 (September 2021): 499–513. https://doi.org/10.1007/s40272-021-00460-4.Full Text Link to Item
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Miller, Laura E., Matthew M. Laughon, Reese H. Clark, Kanecia O. Zimmerman, Christoph P. Hornik, Samia Aleem, P. Brian Smith, and Rachel G. Greenberg. “Vasoactive medications in extremely low gestational age neonates during the first postnatal week.” J Perinatol 41, no. 9 (September 2021): 2330–36. https://doi.org/10.1038/s41372-021-01031-8.Full Text Link to Item
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Gates, Rachel M., Kaitlyn E. Haynes, Kyle J. Rehder, Kanecia O. Zimmerman, Alexandre T. Rotta, and Andrew G. Miller. “High-Flow Nasal Cannula in Pediatric Critical Asthma.” Respir Care 66, no. 8 (August 2021): 1240–46. https://doi.org/10.4187/respcare.08740.Full Text Link to Item
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Korlimarla, Aditi, Jeong-A Lim, Paul McIntosh, Kanecia Zimmerman, Baodong D. Sun, and Priya S. Kishnani. “New Insights into Gastrointestinal Involvement in Late-Onset Pompe Disease: Lessons Learned from Bench and Bedside.” J Clin Med 10, no. 15 (July 30, 2021). https://doi.org/10.3390/jcm10153395.Full Text Open Access Copy Link to Item
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Watson, William D., Stacy J. Suskauer, Gulce Askin, Sophie Nowak, Katherine T. Baum, Linda M. Gerber, Laura S. Blackwell, et al. “Cognitive Recovery During Inpatient Rehabilitation Following Pediatric Traumatic Brain Injury: A Pediatric Brain Injury Consortium Study.” J Head Trauma Rehabil 36, no. 4 (July 2021): 253–63. https://doi.org/10.1097/HTR.0000000000000650.Full Text Link to Item
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Corneli, Amy, Brian Perry, Daniel K. Benjamin, Kanecia O. Zimmerman, and Kanecia O. Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Pediatric Trials Network: Stakeholder views on thanking families and providing study findings on pragmatic pediatric clinical research.” Contemp Clin Trials Commun 22 (June 2021): 100792. https://doi.org/10.1016/j.conctc.2021.100792.Full Text Link to Item
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Le, Jennifer, Rachel G. Greenberg, Daniel K. Benjamin, YoungJun Yoo, Kanecia O. Zimmerman, Michael Cohen-Wolkowiez, Kelly C. Wade, and Kelly C. Administrative Core Committee of the Best Pharmaceuticals for Children Act–Pediatric Trials Network. “Prolonged Post-Discontinuation Antibiotic Exposure in Very Low Birth Weight Neonates at Risk for Early-Onset Sepsis.” J Pediatric Infect Dis Soc 10, no. 5 (May 28, 2021): 615–21. https://doi.org/10.1093/jpids/piaa172.Full Text Link to Item
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Garza, Maryam Y., Michael W. Rutherford, Bhargav Adagarla, Eric Eisenstein, Karan R. Kumar, Kanecia O. Zimmerman, Umit Topaloglu, and Meredith Zozus. “Evaluating Site-Level Implementations of the HL7 FHIR Standard to Support eSource Data Exchange in Clinical Research.” Stud Health Technol Inform 281 (May 27, 2021): 397–401. https://doi.org/10.3233/SHTI210188.Full Text Link to Item
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Abdel-Rahman, Susan M., Ian M. Paul, Chi Hornik, Janice E. Sullivan, Kelly Wade, Paula Delmore, Gaurav Sharma, Daniel K. Benjamin, and Kanecia O. Zimmerman. “Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act.” Pediatrics 147, no. 5 (May 2021). https://doi.org/10.1542/peds.2020-042903.Full Text Link to Item
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Boutzoukas, Angelique E., Daniel K. Benjamin, and Kanecia O. Zimmerman. “Remdesivir: Preliminary Data and Clinical Use Versus Recommended Use.” Pediatrics 147, no. 5 (May 2021). https://doi.org/10.1542/peds.2021-050212.Full Text Link to Item
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Aleem, Samia, Cliff Robbins, Brianna Murphy, Stephen Elliott, Christiana Akinyemi, Nicholas Paredes, Veeral N. Tolia, et al. “The use of supplemental hydrocortisone in the management of persistent pulmonary hypertension of the newborn.” J Perinatol 41, no. 4 (April 2021): 794–800. https://doi.org/10.1038/s41372-021-00943-9.Full Text Link to Item
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Zimmerman, Kanecia O., Ibukunoluwa C. Akinboyo, M Alan Brookhart, Angelique E. Boutzoukas, Kathleen A. McGann, Michael J. Smith, Gabriela Maradiaga Panayotti, et al. “Incidence and Secondary Transmission of SARS-CoV-2 Infections in Schools.” Pediatrics 147, no. 4 (April 2021). https://doi.org/10.1542/peds.2020-048090.Full Text Link to Item
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Commander, Sarah Jane, Huali Wu, Felix Boakye-Agyeman, Chiara Melloni, Chi Dang Hornik, Kanecia Zimmerman, Amira Al-Uzri, et al. “Pharmacokinetics of Hydrochlorothiazide in Children: A Potential Surrogate for Renal Secretion Maturation.” J Clin Pharmacol 61, no. 3 (March 2021): 368–77. https://doi.org/10.1002/jcph.1739.Full Text Link to Item
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Dorismond, Christina, Senyene E. Hunter, Peggy P. McNaull, Kanecia O. Zimmerman, Daniel K. Benjamin, Rachel G. Greenberg, Kristin M. Corey, Matthew M. Laughon, and Wesley M. Jackson. “Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.” J Perinatol 41, no. 3 (March 2021): 577–81. https://doi.org/10.1038/s41372-020-00864-z.Full Text Link to Item
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Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, Julie Autmizguine, Rohit Kalra, Amira Al-Uzri, Catherine M. T. Sherwin, et al. “Population pharmacokinetics of olanzapine in children.” Br J Clin Pharmacol 87, no. 2 (February 2021): 542–54. https://doi.org/10.1111/bcp.14414.Full Text Link to Item
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Hutchins, L. M., A. Shipman, K. O. Zimmerman, and T. S. Heath. “Evaluation of qtc interval effects of antipsychotic medications for intensive care unit delirium in pediatric patients.” Journal of Pediatric Pharmacology and Therapeutics 26, no. 1 (January 1, 2021): 87–91. https://doi.org/10.5863/1551-6776-26.1.87.Full Text
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McMichael, Ali B. V., Kanecia O. Zimmerman, Karan R. Kumar, and Caroline P. Ozment. “Evaluation of effect of scheduled fresh frozen plasma on ECMO circuit life: A randomized pilot trial.” Transfusion 61, no. 1 (January 2021): 42–51. https://doi.org/10.1111/trf.16164.Full Text Link to Item
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Polcwiartek, Laura Bech, P Brian Smith, Daniel K. Benjamin, Kanecia Zimmerman, Alycia Love, Lance Tiu, Sylvia Murray, et al. “Early-onset sepsis in term infants admitted to neonatal intensive care units (2011-2016).” J Perinatol 41, no. 1 (January 2021): 157–63. https://doi.org/10.1038/s41372-020-00860-3.Full Text Link to Item
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Salerno, Sara N., Andrea Edginton, Jacqueline G. Gerhart, Matthew M. Laughon, Namasivayam Ambalavanan, Gregory M. Sokol, Chi D. Hornik, et al. “Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants.” Clin Pharmacol Ther 109, no. 1 (January 2021): 253–62. https://doi.org/10.1002/cpt.1990.Full Text Link to Item
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King, Caitlin E., Elizabeth J. Thompson, Henry P. Foote, Kanecia O. Zimmerman, Kevin D. Hill, Reid Chamberlain, and Christoph P. Hornik. “An evidence-based review of the use of vasoactive and inotropic medications in post-operative paediatric patients after cardiac surgery with cardiopulmonary bypass from 2000 to 2020.” Cardiol Young 30, no. 12 (December 2020): 1757–71. https://doi.org/10.1017/S1047951120004151.Full Text Link to Item
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Maharaj, Anil R., Huali Wu, Christoph P. Hornik, Stephen J. Balevic, Chi D. Hornik, P Brian Smith, Daniel Gonzalez, et al. “Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.” Jama Pediatr 174, no. 10 (October 1, 2020): e202422. https://doi.org/10.1001/jamapediatrics.2020.2422.Full Text Link to Item
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Wolf, Mattie F., Julie Childers, Keyaria D. Gray, Caroline Chivily, Mike Glenn, Laila Jones, Mini Kpa, et al. “Exchange transfusion safety and outcomes in neonatal hyperbilirubinemia.” J Perinatol 40, no. 10 (October 2020): 1506–12. https://doi.org/10.1038/s41372-020-0642-0.Full Text Link to Item
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Miller, Andrew G., Kaitlyn E. Haynes, Rachel M. Gates, Kanecia O. Zimmerman, Kathleen W. Bartlett, Heather S. McLean, and Kyle J. Rehder. “Initial Modified Pulmonary Index Score Predicts Hospital Length of Stay for Asthma Subjects Admitted to the Pediatric Intensive Care Unit.” Respir Care 65, no. 9 (September 2020): 1227–32. https://doi.org/10.4187/respcare.07396.Full Text Link to Item
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Korlimarla, Aditi, Gail A. Spiridigliozzi, Kelly Crisp, Mrudu Herbert, Steven Chen, Michael Malinzak, Mihaela Stefanescu, et al. “Novel approaches to quantify CNS involvement in children with Pompe disease.” Neurology 95, no. 6 (August 11, 2020): e718–32. https://doi.org/10.1212/WNL.0000000000009979.Full Text Open Access Copy Link to Item
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Jackson, Wesley, Genevieve Taylor, Nicolas A. Bamat, Kanecia Zimmerman, Reese Clark, Daniel K. Benjamin, Matthew M. Laughon, Rachel G. Greenberg, and Christoph P. Hornik. “Outcomes associated with surfactant in more mature and larger premature infants with respiratory distress syndrome.” J Perinatol 40, no. 8 (August 2020): 1171–77. https://doi.org/10.1038/s41372-020-0625-1.Full Text Link to Item
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Gray, Keyaria D., Julia A. Messina, Christopher Cortina, Tanasha Owens, Madeline Fowler, Matthew Foster, Simi Gbadegesin, et al. “Probiotic Use and Safety in the Neonatal Intensive Care Unit: A Matched Cohort Study.” J Pediatr 222 (July 2020): 59-64.e1. https://doi.org/10.1016/j.jpeds.2020.03.051.Full Text Link to Item
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Scott, Briana L., Chi D. Hornik, and Kanecia Zimmerman. “Pharmacokinetic, efficacy, and safety considerations for the use of antifungal drugs in the neonatal population.” Expert Opin Drug Metab Toxicol 16, no. 7 (July 2020): 605–16. https://doi.org/10.1080/17425255.2020.1773793.Full Text Link to Item
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Wolf, Mattie F., Julie Childers, Keyaria D. Gray, Caroline Chivily, Mike Glenn, Laila Jones, Mini Kpa, et al. “Authors' response to thrombocytopenia following exchange transfusion in neonates.” J Perinatol 40, no. 7 (July 2020): 1119. https://doi.org/10.1038/s41372-020-0687-0.Full Text Link to Item
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Funk, Ryan S., Nasreen J. Talib, Kanecia O. Zimmerman, Leon van Haandel, and Mara L. Becker. “Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.” J Pediatr 221 (June 2020): 235–39. https://doi.org/10.1016/j.jpeds.2020.01.032.Full Text Link to Item
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Donoghue, Aaron J., Maybelle Kou, Grace L. Good, Carmel Eiger, Mark Nash, Fred M. Henretig, Helen Stacks, et al. “Impact of Personal Protective Equipment on Pediatric Cardiopulmonary Resuscitation Performance: A Controlled Trial.” Pediatr Emerg Care 36, no. 6 (June 2020): 267–73. https://doi.org/10.1097/PEC.0000000000002109.Full Text Link to Item
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Khan, Aleena A., Laura E. Case, Mrudu Herbert, Stephanie DeArmey, Harrison Jones, Kelly Crisp, Kanecia Zimmerman, Mai K. ElMallah, Sarah P. Young, and Priya S. Kishnani. “Higher dosing of alglucosidase alfa improves outcomes in children with Pompe disease: a clinical study and review of the literature.” Genet Med 22, no. 5 (May 2020): 898–907. https://doi.org/10.1038/s41436-019-0738-0.Full Text Link to Item
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Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, David G. Speicher, Janice E. Sullivan, Kevin Watt, Amira Al-Uzri, et al. “Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis.” J Clin Pharmacol 60, no. 5 (May 2020): 636–47. https://doi.org/10.1002/jcph.1562.Full Text Link to Item
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Puia-Dumitrescu, Mihai, Noelle Younge, Daniel K. Benjamin, Katie Lawson, Cordelia Hume, Kennedy Hill, Jonathan Mengistu, et al. “Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.” J Perinatol 40, no. 5 (May 2020): 781–89. https://doi.org/10.1038/s41372-020-0614-4.Full Text Link to Item
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Dallefeld, Samantha H., Jennifer Sherwin, Kanecia O. Zimmerman, and Kevin M. Watt. “Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study.” Perfusion 35, no. 3 (April 2020): 209–16. https://doi.org/10.1177/0267659119868062.Full Text Link to Item
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Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Response to Zhang et al.” Genet Med 22, no. 3 (March 2020): 662. https://doi.org/10.1038/s41436-019-0690-z.Full Text Link to Item
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Ji, Dabin, P Brian Smith, Reese H. Clark, Kanecia O. Zimmerman, Matthew Laughon, Lawrence Ku, and Rachel G. Greenberg. “Wide variation in caffeine discontinuation timing in premature infants.” J Perinatol 40, no. 2 (February 2020): 288–93. https://doi.org/10.1038/s41372-019-0561-0.Full Text Link to Item
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Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Detection of iron deficiency in children with Down syndrome.” Genet Med 22, no. 2 (February 2020): 317–25. https://doi.org/10.1038/s41436-019-0637-4.Full Text Link to Item
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Puia-Dumitrescu, Mihai, Daniel K. Benjamin, P Brian Smith, Rachel G. Greenberg, Nada Abuzaid, Winsome Andrews, Kris Chellani, et al. “Impact of Gastrostomy Tube Placement on Short-Term Weight Gain in Hospitalized Premature Infants.” Jpen J Parenter Enteral Nutr 44, no. 2 (February 2020): 355–60. https://doi.org/10.1002/jpen.1539.Full Text Link to Item
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Dallefeld, S. H., P. B. Smith, E. G. Crenshaw, K. R. Daniel, M. L. Gilleskie, D. S. Smith, S. Balevic, et al. “Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants.” J Neonatal Perinatal Med 13, no. 2 (2020): 159–65. https://doi.org/10.3233/NPM-190214.Full Text Link to Item
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Zimmerman, Kanecia O., Samantha H. Dallefeld, Christoph P. Hornik, and Kevin M. Watt. “Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.” J Pediatr Pharmacol Ther 25, no. 8 (2020): 675–88. https://doi.org/10.5863/1551-6776-25.8.675.Full Text Link to Item
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Ciociola, Elizabeth C., Karan R. Kumar, Kanecia O. Zimmerman, Elizabeth J. Thompson, Melissa Harward, Laura N. Sullivan, Joseph W. Turek, and Christoph P. Hornik. “Association between preoperative respiratory support and outcomes in paediatric cardiac surgery.” Cardiol Young 30, no. 1 (January 2020): 66–73. https://doi.org/10.1017/S1047951119002786.Full Text Open Access Copy Link to Item
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Thompson, Elizabeth J., Daniel K. Benjamin, Rachel G. Greenberg, Karan R. Kumar, Kanecia O. Zimmerman, Matthew Laughon, Reese H. Clark, P Brian Smith, and Christoph P. Hornik. “Pharmacoepidemiology of Furosemide in the Neonatal Intensive Care Unit.” Neonatology 117, no. 6 (2020): 780–84. https://doi.org/10.1159/000510657.Full Text Link to Item
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Zimmerman, Kanecia O., Huali Wu, Matthew Laughon, Rachel G. Greenberg, Richard Walczak, Scott R. Schulman, P Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.” Anesth Analg 129, no. 6 (December 2019): 1519–28. https://doi.org/10.1213/ANE.0000000000003700.Full Text Link to Item
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Miller, Andrew G., Kaitlyn E. Haynes, Rachel M. Gates, Kanecia O. Zimmerman, Travis S. Heath, Kathleen W. Bartlett, Heather S. McLean, and Kyle J. Rehder. “A Respiratory Therapist-Driven Asthma Pathway Reduced Hospital Length of Stay in the Pediatric Intensive Care Unit.” Respir Care 64, no. 11 (November 2019): 1325–32. https://doi.org/10.4187/respcare.06626.Full Text Open Access Copy Link to Item
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Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants.” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.Full Text Link to Item
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Zimmerman, Kanecia O., Daniel K. Benjamin, and Mara L. Becker. “Neonatal Therapeutics: Considerations for Dosing.” Am J Perinatol 36, no. S 02 (July 2019): S18–21. https://doi.org/10.1055/s-0039-1691772.Full Text Link to Item
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Tang, Monica, Kanecia O. Zimmerman, and Jason E. Lang. “Severe childhood asthma exacerbations: Is treatment response variability in the genes?” Pediatr Pulmonol 54, no. 6 (June 2019): 680–82. https://doi.org/10.1002/ppul.24309.Full Text Link to Item
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Zimmerman, Kanecia O., P Brian Smith, Ann W. McMahon, Jean Temeck, Debbie Avant, Dianne Murphy, and Susan McCune. “Duration of Pediatric Clinical Trials Submitted to the US Food and Drug Administration.” Jama Pediatr 173, no. 1 (January 1, 2019): 60–67. https://doi.org/10.1001/jamapediatrics.2018.3227.Full Text Link to Item
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Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.” Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.Full Text Link to Item
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Ge, Shufan, Ryan J. Beechinor, Christoph P. Hornik, Joseph F. Standing, Kanecia Zimmerman, Michael Cohen-Wolkowiez, Matthew M. Laughon, Reese Clark, and Daniel Gonzalez. “External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.” Antimicrob Agents Chemother 62, no. 9 (September 2018). https://doi.org/10.1128/AAC.00669-18.Full Text Link to Item
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Heath, Travis S., Rachel G. Greenberg, Susan R. Hupp, David A. Turner, Christoph P. Hornik, and Kanecia O. Zimmerman. “Effects of Methadone on Corrected Q-T Interval Prolongation in Critically Ill Children.” J Pediatr Pharmacol Ther 23, no. 2 (March 2018): 119–24. https://doi.org/10.5863/1551-6776-23.2.119.Full Text Link to Item
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Patel, Ravi M., Kanecia Zimmerman, David P. Carlton, Reese Clark, Daniel K. Benjamin, and P Brian Smith. “Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants.” J Pediatr 190 (November 2017): 108-111.e1. https://doi.org/10.1016/j.jpeds.2017.07.006.Full Text Link to Item
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Dallefeld, Samantha H., Tracy G. Spears, and Kanecia O. Zimmerman. “The Challenges of Identifying an Oxygenation Index Threshold for Increased Mortality in Pediatric Acute Respiratory Failure.” Respir Care 62, no. 10 (October 2017): 1375–76. https://doi.org/10.4187/respcare.05863.Full Text Link to Item
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Greenberg, Rachel G., Huali Wu, Matthew Laughon, Edmund Capparelli, Stevie Rowe, Kanecia O. Zimmerman, P Brian Smith, and Michael Cohen-Wolkowiez. “Population Pharmacokinetics of Dexmedetomidine in Infants.” J Clin Pharmacol 57, no. 9 (September 2017): 1174–82. https://doi.org/10.1002/jcph.904.Full Text Link to Item
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Ericson, Jessica E., Kanecia O. Zimmerman, Daniel Gonzalez, Chiara Melloni, Jeffrey T. Guptill, Kevin D. Hill, Huali Wu, and Michael Cohen-Wolkowiez. “A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.” Ther Drug Monit 39, no. 1 (February 2017): 13–20. https://doi.org/10.1097/FTD.0000000000000364.Full Text Link to Item
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Zimmerman, Kanecia O., P Brian Smith, Daniel K. Benjamin, Matthew Laughon, Reese Clark, Chani Traube, Til Stürmer, and Christoph P. Hornik. “Sedation, Analgesia, and Paralysis during Mechanical Ventilation of Premature Infants.” J Pediatr 180 (January 2017): 99-104.e1. https://doi.org/10.1016/j.jpeds.2016.07.001.Full Text Link to Item
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Ku, Lawrence C., Kanecia Zimmerman, Daniel K. Benjamin, Reese H. Clark, Christoph P. Hornik, P Brian Smith, and P Brian Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Safety of Enalapril in Infants Admitted to the Neonatal Intensive Care Unit.” Pediatr Cardiol 38, no. 1 (January 2017): 155–61. https://doi.org/10.1007/s00246-016-1496-2.Full Text Link to Item
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Zimmerman, Kanecia O., Huali Wu, Rachel Greenberg, Jeffrey T. Guptill, Kevin Hill, Uptal D. Patel, Lawrence Ku, et al. “Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients.” Ther Drug Monit 38, no. 5 (October 2016): 600–606. https://doi.org/10.1097/FTD.0000000000000313.Full Text Link to Item
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Zimmerman, Kanecia, Martin Putera, Christoph P. Hornik, P. Brian Smith, Daniel K. Benjamin, Yeruk Mulugeta, Gilbert J. Burckart, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval.” Clin Ther 38, no. 9 (September 2016): 1995–2005. https://doi.org/10.1016/j.clinthera.2016.06.003.Full Text Link to Item
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Zimmerman, Kanecia, Daniel Gonzalez, Geeta K. Swamy, and Michael Cohen-Wolkowiez. “Pharmacologic studies in vulnerable populations: Using the pediatric experience.” Semin Perinatol 39, no. 7 (November 2015): 532–36. https://doi.org/10.1053/j.semperi.2015.08.007.Full Text Link to Item
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Rehder, Kyle J., Elizabeth A. Wilson, Kanecia O. Zimmerman, Coleen K. Cunningham, and David A. Turner. “Detection of Multiple Respiratory Viruses Associated With Mortality and Severity of Illness in Children.” Pediatr Crit Care Med 16, no. 7 (September 2015): e201–6. https://doi.org/10.1097/PCC.0000000000000492.Full Text Link to Item
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Zimmerman, Kanecia O., Christoph P. Hornik, Lawrence Ku, Kevin Watt, Matthew M. Laughon, Margarita Bidegain, Reese H. Clark, and P Brian Smith. “Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life.” J Pediatr 167, no. 2 (August 2015): 299-304.e3. https://doi.org/10.1016/j.jpeds.2015.04.059.Full Text Link to Item
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Johnson, David P., Kanecia Zimmerman, Betty Staples, Kathleen A. McGann, Karen Frush, and David A. Turner. “Multicenter development, implementation, and patient safety impacts of a simulation-based module to teach handovers to pediatric residents.” Hosp Pediatr 5, no. 3 (March 2015): 154–59. https://doi.org/10.1542/hpeds.2014-0050.Full Text Link to Item
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Gonzalez, Daniel, Chiara Melloni, Brenda B. Poindexter, Ram Yogev, Andrew M. Atz, Janice E. Sullivan, Susan R. Mendley, et al. “Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots.” Bioanalysis 7, no. 9 (2015): 1137–49. https://doi.org/10.4155/bio.15.38.Full Text Link to Item
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Anderson, Anna W., P Brian Smith, Kristin M. Corey, Kevin D. Hill, Kanecia O. Zimmerman, Reese H. Clark, and Christoph P. Hornik. “Clinical outcomes in very low birth weight infants with major congenital heart defects.” Early Hum Dev 90, no. 12 (December 2014): 791–95. https://doi.org/10.1016/j.earlhumdev.2014.09.006.Full Text Link to Item
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Zimmerman, Kanecia O., Susan R. Hupp, Ali Bourguet-Vincent, Erin A. Bressler, Eileen M. Raynor, David A. Turner, and Kyle J. Rehder. “Acute upper-airway obstruction by a lingual thyroglossal duct cyst and implications for advanced airway management.” Respir Care 59, no. 7 (July 2014): e98–102. https://doi.org/10.4187/respcare.02513.Full Text Link to Item
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Zimmerman, K. O., and P. B. Smith. “Current epidemiology and management of invasive candidiasis in infants.” Current Fungal Infection Reports 8, no. 1 (March 1, 2014): 1–11. https://doi.org/10.1007/s12281-013-0167-5.Full Text
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Book Sections
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Zimmerman, K., and D. K. Benjamin. “Necrotizing Enterocolitis.” In Principles and Practice of Pediatric Infectious Diseases, 394-397.e2, 2018. https://doi.org/10.1016/B978-0-323-40181-4.00058-X.Full Text
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Conference Papers
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Ganguly, Samit, Andrea N. Edginton, Jacqueline G. Gerhart, Michael Cohen-Wolkowiez, Rachel G. Greenberg, Daniel Gonzalez, and Daniel Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants.” In Clin Pharmacokinet, 60:1591–1604, 2021. https://doi.org/10.1007/s40262-021-01046-6.Full Text Link to Item
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Commander, S. J., D. Gonzalez, K. R. Kumar, T. Spears, M. Cohen-Wolkowiez, K. O. Zimmerman, S. J. Balevic, and C. P. Hornik. “The relationship between simulated milrinone exposure and hypotension in children.” In Cardiology in the Young, 2021. https://doi.org/10.1017/S1047951121003103.Full Text
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Garza, Maryam Y., Michael Rutherford, Sahiti Myneni, Susan Fenton, Anita Walden, Umit Topaloglu, Eric Eisenstein, et al. “Evaluating the Coverage of the HL7 ® FHIR ® Standard to Support eSource Data Exchange Implementations for use in Multi-Site Clinical Research Studies.” In Amia Annu Symp Proc, 2020:472–81, 2020.Link to Item
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