Kanecia Obie Zimmerman
Assistant Professor of Pediatrics
Current Research Interests
Pharmacoepidemiology
Clinical Pharmacology
Drug Safety in Pediatric Critical Illness
Clinical Pharmacology
Drug Safety in Pediatric Critical Illness
Current Appointments & Affiliations
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2015
- Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2015
Contact Information
- 2400 Pratt Street, Durham, NC 27710
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kanecia.obie@duke.edu
(919) 668-8651
- Background
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Education, Training, & Certifications
- Clinical Research Fellowship, Duke Clinical Research Institute, Duke University School of Medicine 2013 - 2015
- Critical Care Medicine Fellowship, Department Of Pediatrics, Duke University School of Medicine 2012 - 2015
- Medical Instructor, Department Of Medicine (Internal Med), Duke University School of Medicine 2011 - 2012
- Medical Instructor/Chief Resident, Department Of Pediatrics, Duke University School of Medicine 2011 - 2012
- Medicine-Pediatrics Residency Training, Pediatrics, Duke University 2007 - 2011
- M.D., Duke University School of Medicine 2007
- M.P.H., University of North Carolina at Chapel Hill 2006
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Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2011 - 2013
- Medical Instructor in the Department of Pediatrics, Pediatrics, Primary Care Pediatrics, Pediatrics 2011 - 2012
- Expertise
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Subject Headings
- Research
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Selected Grants
- Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT) awarded by National Institutes of Health 2016 - 2023
- Duke Summer Training in Academic Research (Duke's STAR) awarded by National Institutes of Health 2018 - 2023
- PTN2- TO# BPCA Pharmacology Studies awarded by National Institute for Child Health & Human Develo 2018 - 2022
- Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2021
- Investigating polypharmacy-related adverse events in critically ill children using electronic health records and simulated drug levels awarded by National Institutes of Health 2017 - 2021
- Prospect of Direct Benefit in Pediatric Reseach in Type 1 Diabetes (T1D) awarded by Juvenile Diabetes Research Foundation 2018 - 2019
- PTN TO# Anesthesia awarded by National Institutes of Health 2017 - 2019
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2017 - 2019
- Pediatric Trials Network_ Task Order 1_ Core Function Activities awarded by National Institute for Child Health & Human Develo 2018 - 2019
- Duke CTSA (KL2) awarded by National Institutes of Health 2013 - 2018
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Zimmerman, KO, Smith, PB, McMahon, AW, Temeck, J, Avant, D, Murphy, D, and McCune, S. "Duration of Pediatric Clinical Trials Submitted to the US Food and Drug Administration." Jama Pediatrics (November 19, 2018). Full Text
- Wang, LA, Smith, PB, Laughon, M, Goldberg, RN, Ku, LC, Zimmerman, KO, Balevic, S, Clark, RH, Benjamin, DK, Greenberg, RG, and Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee, . "Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants." Early Human Development 125 (October 2018): 26-30. Full Text
- Ge, S, Beechinor, RJ, Hornik, CP, Standing, JF, Zimmerman, K, Cohen-Wolkowiez, M, Laughon, MM, Clark, R, and Gonzalez, D. "External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database." Antimicrobial Agents and Chemotherapy 62, no. 9 (September 2018). Full Text
- Heath, TS, Greenberg, RG, Hupp, SR, Turner, DA, Hornik, CP, and Zimmerman, KO. "Effects of Methadone on Corrected Q-T Interval Prolongation in Critically Ill Children." The Journal of Pediatric Pharmacology and Therapeutics : Jppt : the Official Journal of Ppag 23, no. 2 (March 2018): 119-124. Full Text
- Patel, RM, Zimmerman, K, Carlton, DP, Clark, R, Benjamin, DK, and Smith, PB. "Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants." The Journal of Pediatrics 190 (November 2017): 108-111.e1. Full Text
- Dallefeld, SH, Spears, TG, and Zimmerman, KO. "The Challenges of Identifying an Oxygenation Index Threshold for Increased Mortality in Pediatric Acute Respiratory Failure." Respiratory care 62, no. 10 (October 2017): 1375-1376. Full Text
- Greenberg, RG, Wu, H, Laughon, M, Capparelli, E, Rowe, S, Zimmerman, KO, Smith, PB, and Cohen-Wolkowiez, M. "Population Pharmacokinetics of Dexmedetomidine in Infants." Journal of clinical pharmacology 57, no. 9 (September 2017): 1174-1182. Full Text
- Ericson, JE, Zimmerman, KO, Gonzalez, D, Melloni, C, Guptill, JT, Hill, KD, Wu, H, and Cohen-Wolkowiez, M. "A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation." Therapeutic Drug Monitoring 39, no. 1 (February 2017): 13-20. (Review) Full Text
- Ku, LC, Zimmerman, K, Benjamin, DK, Clark, RH, Hornik, CP, Smith, PB, and Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee, . "Safety of Enalapril in Infants Admitted to the Neonatal Intensive Care Unit." Pediatric Cardiology 38, no. 1 (January 2017): 155-161. Full Text
- Zimmerman, KO, Smith, PB, Benjamin, DK, Laughon, M, Clark, R, Traube, C, Stürmer, T, and Hornik, CP. "Sedation, Analgesia, and Paralysis during Mechanical Ventilation of Premature Infants." The Journal of Pediatrics 180 (January 2017): 99-104.e1. Full Text
- Zimmerman, KO, Wu, H, Greenberg, R, Guptill, JT, Hill, K, Patel, UD, Ku, L, Gonzalez, D, Hornik, C, Jiang, W, Zheng, N, Melloni, C, and Cohen-Wolkowiez, M. "Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients." Therapeutic Drug Monitoring 38, no. 5 (October 2016): 600-606. Full Text
- Zimmerman, K, Putera, M, Hornik, CP, Brian Smith, P, Benjamin, DK, Mulugeta, Y, Burckart, GJ, Cohen-Wolkowiez, M, and Gonzalez, D. "Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval." Clinical therapeutics 38, no. 9 (September 2016): 1995-2005. (Review) Full Text
- Zimmerman, K, Gonzalez, D, Swamy, GK, and Cohen-Wolkowiez, M. "Pharmacologic studies in vulnerable populations: Using the pediatric experience." Seminars in Perinatology 39, no. 7 (November 2015): 532-536. (Review) Full Text
- Rehder, KJ, Wilson, EA, Zimmerman, KO, Cunningham, CK, and Turner, DA. "Detection of Multiple Respiratory Viruses Associated With Mortality and Severity of Illness in Children." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 16, no. 7 (September 2015): e201-e206. Full Text
- Zimmerman, KO, Hornik, CP, Ku, L, Watt, K, Laughon, MM, Bidegain, M, Clark, RH, and Smith, PB. "Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life." The Journal of pediatrics 167, no. 2 (August 2015): 299-304.e3. Full Text
- Johnson, DP, Zimmerman, K, Staples, B, McGann, KA, Frush, K, and Turner, DA. "Multicenter development, implementation, and patient safety impacts of a simulation-based module to teach handovers to pediatric residents." Hospital pediatrics 5, no. 3 (March 2015): 154-159. Full Text
- Gonzalez, D, Melloni, C, Poindexter, BB, Yogev, R, Atz, AM, Sullivan, JE, Mendley, SR, Delmore, P, Delinsky, A, Zimmerman, K, Lewandowski, A, Harper, B, Lewis, KC, Benjamin, DK, Cohen-Wolkowiez, M, and Best Pharmaceuticals for Children Act--Pediatric Trials Network Administrative Core Committee, . "Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots." Bioanalysis 7, no. 9 (January 2015): 1137-1149. Full Text
- Anderson, AW, Smith, PB, Corey, KM, Hill, KD, Zimmerman, KO, Clark, RH, and Hornik, CP. "Clinical outcomes in very low birth weight infants with major congenital heart defects." Early human development 90, no. 12 (December 2014): 791-795. Full Text
- Zimmerman, KO, and Smith, PB. "Erratum to: Current Epidemiology and Management of Invasive Candidiasis in Infants." Current Fungal Infection Reports 8, no. 3 (September 2014): 242-242. Full Text
- Zimmerman, KO, Hupp, SR, Bourguet-Vincent, A, Bressler, EA, Raynor, EM, Turner, DA, and Rehder, KJ. "Acute upper-airway obstruction by a lingual thyroglossal duct cyst and implications for advanced airway management." Respiratory Care 59, no. 7 (July 2014): e98-e102. Full Text
- Zimmerman, KO, and Smith, PB. "Current Epidemiology and Management of Invasive Candidiasis in Infants." Current Fungal Infection Reports 8, no. 1 (March 2014): 1-11. Full Text
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Book Sections
- Zimmerman, K, and Benjamin, DK. "Necrotizing Enterocolitis." In Principles and Practice of Pediatric Infectious Diseases, 394-397.e2.: Elsevier, 2018. Full Text
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