Scholars@Duke
Karen P. Flores Rosario

Karen P. Flores Rosario

Assistant Professor of Medicine
Medicine, Cardiology

Scholarly Works

Bridging the Gap Between Genetic Cardiomyopathies and Pregnancy.

Journal article JACC Adv · June 2026 Genetic testing is increasingly common for people with cardiomyopathies and arrhythmias, with cascade screening recommended for first-degree relatives of those carrying pathogenic or likely pathogenic variants. Consequently, a growing number of women of ch ... Full text Link to item Cite

Listing patterns at the highest volume heart transplant centers: Multiple roads to transplant.

Journal article JHLT Open · February 2026 The current heart transplantation (HT) allocation system added additional progressive statuses to differentiate the highest risk patients and decrease waitlist mortality. We analyzed United Network for Organ Sharing thoracic organ data (10/18/2018-6/30/202 ... Full text Link to item Cite

Smartwatch bradycardia alarms leading to a diagnosis of lamin A/C cardiomyopathy: a case report.

Journal article Eur Heart J Case Rep · September 2025 BACKGROUND: Genetic aetiologies of early-onset arrhythmias and cardiomyopathy (CM) are common, but timely diagnosis requires a high index of suspicion. CASE SUMMARY: An asymptomatic 47-year-old man presented to cardiology clinic for smartwatch low-rate ala ... Full text Open Access Link to item Cite

Hispanic/Latino ethnic background and genetic ancestry in relation to atherosclerotic cardiovascular disease risk estimation: Findings from the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal article Am J Prev Cardiol · September 2025 BACKGROUND: Hispanics/Latinos are a heterogenous population with no validated atherosclerotic cardiovascular disease (ASCVD) risk estimation tool. We examined performance of the pooled cohort equation (PCE) across Hispanic/Latino background groups and quan ... Full text Link to item Cite

Pregnancy and Delivery Care for a Patient With a HeartMate 3.

Journal article JACC Case Rep · June 4, 2025 BACKGROUND: The limited available data on pregnancies among patients with left ventricular assist devices (LVADs) in situ shows elevated rates of maternal and fetal/neonatal morbidity and mortality. The first fully magnetically levitated device providing c ... Full text Open Access Link to item Cite

SMARTWATCH ALERTS LEADING TO DIAGNOSIS OF GENETIC DILATED CARDIOMYOPATHY

Conference JACC-JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · April 1, 2025 Link to item Cite

Patient Perceptions and Knowledge Surrounding Pregnancy After Heart Transplantation: A Multicenter Study.

Journal article Circ Heart Fail · August 2024 BACKGROUND: More women of childbearing age are surviving after heart transplantation (HT), many of whom have a desire to become pregnant. Limited data exist evaluating patients' perspectives, receipt of counseling, and knowledge surrounding contraception, ... Full text Link to item Cite

Multimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions.

Journal article Circ Cardiovasc Imaging · February 2024 Innovations in cardiac imaging have fundamentally advanced the understanding and treatment of cardiovascular disease. These advances in noninvasive cardiac imaging have also expanded the role of the cardiac imager and dramatically increased the demand for ... Full text Link to item Cite

Induced Abortion for Maternal Cardiac Indication: 2 Cases of Unintended Pregnancy With LVAD.

Journal article JACC Case Rep · December 6, 2023 We present 2 cases of patients with left ventricular assist device who underwent an induced abortion in the first and second trimester, respectively. Comprehensive counseling is critical for this patient population, and close coordination of interdisciplin ... Full text Link to item Cite

Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States.

Journal article JACC Heart Fail · December 2023 BACKGROUND: Improved survival following heart transplantation (HT) has led to more recipients contemplating pregnancy, but data on outcomes are limited. OBJECTIVES: The authors used a national data set to investigate and describe outcomes of pregnancies an ... Full text Link to item Cite

LMNA Cardiomyopathy: Important Considerations for the Heart Failure Clinician.

Journal article J Card Fail · December 2023 BACKGROUND: A diagnosis of Lamin proteins A and C cardiomyopathy (LMNA-CM) not only impacts disease prognosis, but also leads to specific guideline-recommended treatment options for these patients. This etiology is fundamentally different from other geneti ... Full text Link to item Cite

Incidence and Predictors of Relapse After Weaning Immune Suppressive Therapy in Cardiac Sarcoidosis.

Journal article Am J Cardiol · October 1, 2023 Cardiac sarcoidosis (CS) is a relapsing-remitting disease, and immune suppression (IS) is the mainstay of therapy. Predictors of relapse for patients with CS in remission are not well characterized. We assessed incidence of relapse in consecutive patients ... Full text Link to item Cite

MIMICKING THE GREAT MIMICKER: LMNA CARDIOMYOPATHY PRESENTING AS ISOLATED CARDIAC SARCOIDOSIS

Conference Journal of the American College of Cardiology · March 2023 Full text Cite

Cardiac Sarcoidosis: Current Approaches to Diagnosis and Management.

Journal article Curr Allergy Asthma Rep · December 2022 PURPOSE OF REVIEW: Cardiac sarcoidosis (CS) is an important cause of non-ischemic cardiomyopathy and has specific diagnostic and therapeutic considerations. With advances in imaging techniques and treatment approaches, the approach to monitoring disease pr ... Full text Link to item Cite

Cutaneous Vasculitis and Central Nervous System Infarctions due to Varicella Zoster Virus Vasculopathy in an Immunocompromised Patient.

Journal article Case Rep Transplant · 2020 Varicella zoster virus (VZV) infection commonly presents as varicella during childhood, and zoster, later in life. Here, we present a rare and interesting case of VZV infection that manifested with both cerebral and spinal infarctions and cutaneous vasculi ... Full text Link to item Cite

The impact of erythropoietin and iron status on brain myelination in the newborn rat.

Journal article J Neurosci Res · September 2018 Erythropoietin (Epo) drives iron (Fe) utilization for erythropoiesis, but the potentially resultant tissue iron deficiency (ID) can also impede brain development. Conversely, Epo binds to Epo receptors (EpoR) on immature brain oligodendrocytes and neurons, ... Full text Link to item Cite

Acute Kidney Injury in Heart Failure Revisited-The Ameliorating Impact of "Decongestive Diuresis" on Renal Dysfunction in Type 1 Acute Cardiorenal Syndrome: Accelerated Rising Pro B Naturetic Peptide Is a Predictor of Good Renal Prognosis.

Journal article J Clin Med · August 29, 2017 There is mounting evidence that forward heart failure as manifested by low cardiac output alone does not define the degree of renal dysfunction in cardiorenal syndrome. As a result, the term "congestive renal failure" was coined in 2012 by Ross to depict t ... Full text Link to item Cite