Scholars@Duke

• Research
• 

  Selected Grants

  • Aging in 1000 healthy midlife adults: Phase 52 of the Dunedin Study awarded by National Institutes of Health 2009 - 2027
  • Validating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4x awarded by National Institutes of Health 2022 - 2026
  • Comprehensive portrait of long-term cannabis users: Are they ready for old age? awarded by National Institutes of Health 2020 - 2024
  • Social Relationship Qualities as Predictors of Health & Aging from Adolescence thru Midlife awarded by University of Virginia - Charlottesville 2018 - 2022
  • Midlife Pace of Aging in the Dunedin Study awarded by King's College London 2017 - 2021
• 

  External Relationships

  • TruDiagnostic LLC
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Sugden, Karen, Avshalom Caspi, Maxwell L. Elliott, Kyle J. Bourassa, Kartik Chamarti, David L. Corcoran, Ahmad R. Hariri, et al. “Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia.” Neurology, July 2022, 10.1212/WNL.0000000000200898. https://doi.org/10.1212/wnl.0000000000200898.
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    • Rasmussen, Line Jee Hartmann, Terrie E. Moffitt, Jesper Eugen-Olsen, Daniel W. Belsky, Andrea Danese, HonaLee Harrington, Renate M. Houts, et al. “Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.” Journal of Child Psychology and Psychiatry, and Allied Disciplines 60, no. 2 (February 2019): 199–208. https://doi.org/10.1111/jcpp.12928.
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    • Hannon, Eilis, Olivia Knox, Karen Sugden, Joe Burrage, Chloe C. Y. Wong, Daniel W. Belsky, David L. Corcoran, et al. “Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.” Plos Genetics 14, no. 8 (August 2018): e1007544. https://doi.org/10.1371/journal.pgen.1007544.
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    • Belsky, Daniel W., Terrie E. Moffitt, Alan A. Cohen, David L. Corcoran, Morgan E. Levine, Joseph A. Prinz, Jonathan Schaefer, et al. “Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?” American Journal of Epidemiology 187, no. 6 (June 2018): 1220–30. https://doi.org/10.1093/aje/kwx346.
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    • Marzi, Sarah J., Karen Sugden, Louise Arseneault, Daniel W. Belsky, Joe Burrage, David L. Corcoran, Andrea Danese, et al. “Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood.” The American Journal of Psychiatry 175, no. 6 (June 2018): 517–29. https://doi.org/10.1176/appi.ajp.2017.17060693.
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    • Wertz, J., A. Caspi, D. W. Belsky, A. L. Beckley, L. Arseneault, J. C. Barnes, D. L. Corcoran, et al. “Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior.” Psychological Science 29, no. 5 (May 2018): 791–803. https://doi.org/10.1177/0956797617744542.
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    • Baldwin, Jessie R., Louise Arseneault, Avshalom Caspi, Helen L. Fisher, Terrie E. Moffitt, Candice L. Odgers, Carmine Pariante, et al. “Childhood victimization and inflammation in young adulthood: A genetically sensitive cohort study.” Brain, Behavior, and Immunity 67 (January 2018): 211–17. https://doi.org/10.1016/j.bbi.2017.08.025.
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    • Reuben, Aaron, Avshalom Caspi, Daniel W. Belsky, Jonathan Broadbent, Honalee Harrington, Karen Sugden, Renate M. Houts, Sandhya Ramrakha, Richie Poulton, and Terrie E. Moffitt. “Association of Childhood Blood Lead Levels With Cognitive Function and Socioeconomic Status at Age 38 Years and With IQ Change and Socioeconomic Mobility Between Childhood and Adulthood.” Jama 317, no. 12 (March 2017): 1244–51. https://doi.org/10.1001/jama.2017.1712.
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    • Schaefer, Jonathan D., Avshalom Caspi, Daniel W. Belsky, Honalee Harrington, Renate Houts, Salomon Israel, Morgan E. Levine, et al. “Early-Life Intelligence Predicts Midlife Biological Age.” The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 71, no. 6 (November 2016): 968–77. https://doi.org/10.1093/geronb/gbv035.
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    • Belsky, Daniel W., Terrie E. Moffitt, David L. Corcoran, Benjamin Domingue, HonaLee Harrington, Sean Hogan, Renate Houts, et al. “The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development.” Psychological Science 27, no. 7 (July 2016): 957–72. https://doi.org/10.1177/0956797616643070.
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    • Sugden, Karen, Terrie E. Moffitt, Lauriane Pinto, Richie Poulton, Benjamin S. Williams, and Avshalom Caspi. “Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort.” Plos One 11, no. 2 (February 17, 2016). https://doi.org/10.1371/journal.pone.0148435.
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    • Sugden, Karen, Terrie E. Moffitt, Lauriane Pinto, Richie Poulton, Benjamin S. Williams, and Avshalom Caspi. “Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort.” Plos One 11, no. 2 (January 2016): e0148435. https://doi.org/10.1371/journal.pone.0148435.
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    • Moffitt, Terrie E., Renate Houts, Philip Asherson, Daniel W. Belsky, David L. Corcoran, Maggie Hammerle, HonaLee Harrington, et al. “Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study.” The American Journal of Psychiatry 172, no. 10 (October 2015): 967–77. https://doi.org/10.1176/appi.ajp.2015.14101266.
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    • Belsky, Daniel W., Avshalom Caspi, Renate Houts, Harvey J. Cohen, David L. Corcoran, Andrea Danese, HonaLee Harrington, et al. “Quantification of biological aging in young adults.” Proc Natl Acad Sci U S A 112, no. 30 (July 28, 2015): E4104–10. https://doi.org/10.1073/pnas.1506264112.
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    • Sugden, Karen, Andrea Danese, Idan Shalev, Benjamin S. Williams, and Avshalom Caspi. “Blood Substrate Collection and Handling Procedures under Pseudo-Field Conditions: Evaluation of Suitability for Inflammatory Biomarker Measurement.” Biodemography and Social Biology 61, no. 3 (January 2015): 273–84. https://doi.org/10.1080/19485565.2015.1062717.
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    • Shalev, I., T. E. Moffitt, A. W. Braithwaite, A. Danese, N. I. Fleming, S. Goldman-Mellor, H. L. Harrington, et al. “Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder.” Molecular Psychiatry 19, no. 11 (November 2014): 1163–70. https://doi.org/10.1038/mp.2013.183.
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    • Shalev, Idan, Avshalom Caspi, Antony Ambler, Daniel W. Belsky, Simon Chapple, Harvey Jay Cohen, Salomon Israel, et al. “Perinatal complications and aging indicators by midlife.” Pediatrics 134, no. 5 (November 2014): e1315–23. https://doi.org/10.1542/peds.2014-1669.
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    • Belsky, Daniel W., Idan Shalev, Malcolm R. Sears, Robert J. Hancox, Hona Lee Harrington, Renate Houts, Terrie E. Moffitt, et al. “Is chronic asthma associated with shorter leukocyte telomere length at midlife?” American Journal of Respiratory and Critical Care Medicine 190 (August 2014): 384–91. https://doi.org/10.1164/rccm.201402-0370OC.
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    • Belsky, Daniel W., Terrie E. Moffitt, Timothy B. Baker, Andrea K. Biddle, James P. Evans, HonaLee Harrington, Renate Houts, et al. “Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.” Jama Psychiatry 70, no. 5 (May 2013): 534–42. https://doi.org/10.1001/jamapsychiatry.2013.736.
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    • Shalev, I., T. E. Moffitt, K. Sugden, B. Williams, R. M. Houts, A. Danese, J. Mill, L. Arseneault, and A. Caspi. “Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study.” Molecular Psychiatry 18, no. 5 (May 2013): 576–81. https://doi.org/10.1038/mp.2012.32.
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    • Belsky, Daniel W., Terrie E. Moffitt, Karen Sugden, Benjamin Williams, Renate Houts, Jeanette McCarthy, and Avshalom Caspi. “Development and evaluation of a genetic risk score for obesity.” Biodemography & Social Biology 59 (May 2013): 85–100.
    • Belsky, Daniel W., Malcolm R. Sears, Robert J. Hancox, Honalee Harrington, Renate Houts, Terrie E. Moffitt, Karen Sugden, Benjamin Williams, Richie Poulton, and Avshalom Caspi. “Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.” The Lancet Respiratory Medicine 1 (2013): 453–361. https://doi.org/10.1016/S2213-2600(13)70101-2.
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    • Belsky, Daniel W., Terrie E. Moffitt, Renate Houts, Gary G. Bennett, Andrea K. Biddle, James A. Blumenthal, James P. Evans, et al. “Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study.” Arch Pediatr Adolesc Med 166, no. 6 (June 1, 2012): 515–21. https://doi.org/10.1001/archpediatrics.2012.131.
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    • Gunduz Cinar, O., K. P. Macpherson, R. Cinar, J. Gamble George, K. Sugden, B. Williams, G. Godlewski, et al. “Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.” Molecular Psychiatry, 2012. https://doi.org/10.1038/mp.2012.72.
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    • Uher, Rudolf, Avshalom Caspi, Renate Houts, Karen Sugden, Benjamin Williams, Richie Poulton, and Terrie E. Moffitt. “Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.” Journal of Affective Disorders 135, no. 1–3 (December 2011): 56–65. https://doi.org/10.1016/j.jad.2011.03.010.
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    • Danese, A., A. Caspi, B. Williams, A. Ambler, K. Sugden, J. Mika, H. Werts, et al. “Biological embedding of stress through inflammation processes in childhood.” Molecular Psychiatry 16, no. 3 (March 2011): 244–46. https://doi.org/10.1038/mp.2010.5.
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    • Sugden, Karen, Louise Arseneault, HonaLee Harrington, Terrie E. Moffitt, Benjamin Williams, and Avshalom Caspi. “Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization.” Journal of the American Academy of Child and Adolescent Psychiatry 49, no. 8 (August 2010): 830–40. https://doi.org/10.1016/j.jaac.2010.01.024.
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    • Polanczyk, Guilherme, Avshalom Caspi, Benjamin Williams, Thomas S. Price, Andrea Danese, Karen Sugden, Rudolf Uher, Richie Poulton, and Terrie E. Moffitt. “Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.” Archives of General Psychiatry 66, no. 9 (September 2009): 978–85. https://doi.org/10.1001/archgenpsychiatry.2009.114.
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    • Caspi, Avshalom, Karen Sugden, Terrie E. Moffitt, Alan Taylor, Ian W. Craig, HonaLee Harrington, Joseph McClay, et al. “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Science (New York, N.Y.) 301, no. 5631 (July 2003): 386–89. https://doi.org/10.1126/science.1083968.
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    • Mill, J. S., A. Caspi, J. McClay, K. Sugden, S. Purcell, P. Asherson, I. Craig, et al. “The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study.” Molecular Psychiatry 7, no. 4 (January 2002): 383–91. https://doi.org/10.1038/sj.mp.4000984.
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