Karen Sugden

Journal Article Neurology · September 2022 Background and objectivesDNA methylation algorithms are increasingly used to estimate biological aging; however, how these proposed measures of whole-organism biological aging relate to aging in the brain is not known. We used data from the Alzhei ... Full text Cite

Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.

Journal Article Journal of child psychology and psychiatry, and allied disciplines · February 2019 BackgroundChildhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasmi ... Full text Cite

Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.

Journal Article PLoS genetics · August 2018 Variation in DNA methylation is being increasingly associated with health and disease outcomes. Although DNA methylation is hypothesized to be a mechanism by which both genetic and non-genetic factors can influence the regulation of gene expression, little ... Full text Cite

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Karen Sugden

Current Appointments & Affiliations

Recent Publications

Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia.

Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.

Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.

Recent Grants

Social Relationship Qualities as Predictors of Health & Aging from Adolescence thru Midlife

Aging in 1000 healthy midlife adults: Phase 52 of the Dunedin Study

Validating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4x