Journal articleArthritis Res Ther · April 21, 2026
BACKGROUND: In patients with rheumatoid arthritis (RA), the immunoglobulin G (IgG) glycome is altered and characterized by decreased galactosylation. The goals of our exploratory study were to identify (1) alterations in the IgG and plasma glycome and Glyc ...
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Journal articleACR Open Rheumatol · December 2025
OBJECTIVE: To evaluate the long-term impacts of a 16-week remotely supervised exercise and weight loss intervention for rheumatoid arthritis (Supervised Weight Loss and Exercise Training in Rheumatoid Arthritis [SWET-RA]). METHODS: In total, 21 older adult ...
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Journal articleBMC Prim Care · October 27, 2025
BACKGROUND: The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a large-scale research study aimed at elucidating the effects of exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activi ...
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Journal articleSports Med Health Sci · September 2025
PURPOSE: The purpose of this narrative review is to: 1) summarize findings from the three Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) randomized trials regarding the differential effects of exercise amount, intensit ...
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Journal articleJ Appl Physiol (1985) · June 1, 2025
Assess the cumulative effects of different weekly exercise energy expenditures, with similar total program volume and intensity, on cardiorespiratory fitness (CRF) and metabolic syndrome (MetS). Following the 9-mo Studies of a Targeted Risk Reduction Inter ...
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Journal articleCirculation · March 11, 2025
Introduction:
Attending cardiac rehabilitation (CR) improves fitness and quality of life and decreases the risk of future death from heart disease. Unfortunately, once an individual finishes a CR prog ...
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Journal articleTransl J Am Coll Sports Med · 2025
INTRODUCTION: This study aimed to identify barriers and predictors of self-reported physical activity (PA) maintenance 10 yr following the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE I) randomized trial among young o ...
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Journal articleCirculation · November 12, 2024
Background:
While exercise training elicits substantial health benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining if a relatively modest duration of exerc ...
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Journal articleCirculation · November 12, 2024
Background:
While cardiometabolic disease (CMD) is the top cause of death for US women, age at onset is 10-20 years after that of men largely due to menopausal estrogen loss. Along with premenopausal ...
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Journal articleHealth Psychol · October 2024
OBJECTIVE: Low neuroticism, high extraversion, and high conscientiousness are related to physical activity (PA). We tested whether the small size and heterogeneity of these relationships result because personality traits influence one another as well as be ...
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Journal articleJ Appl Physiol (1985) · September 1, 2024
Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of these molecular r ...
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Journal articleAnn Behav Med · April 11, 2024
BACKGROUND: Despite the benefits of exercise, many individuals are unable or unwilling to adopt an exercise intervention. PURPOSE: The purpose of this analysis was to identify putative genetic variants associated with dropout from exercise training interve ...
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Journal articleCirculation · March 19, 2024
Introduction:
Individuals with rheumatoid arthritis (RA) have an increased risk for cardiometabolic disease. By improving traditional markers of cardiometabolic health, interventions that induce weigh ...
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Journal articleCirculation · November 7, 2023
Introduction:
STRRIDE I (Studies of Targeting Risk Reduction Interventions through Defined Exercise) was an 8-month exercise intervention conducted from 1998-2003. Participants were randomized to an i ...
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Journal articleJ Cardiopulm Rehabil Prev · May 1, 2023
PURPOSE: Suboptimal adherence is a major limitation to achieving the benefits of exercise interventions, and our ability to predict and improve adherence is limited. The purpose of this analysis was to identify baseline clinical and demographic characteris ...
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Journal articleObesity (Silver Spring) · February 2023
OBJECTIVE: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. M ...
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Journal articleTransl J Am Coll Sports Med · 2023
PURPOSE: To identify baseline demographic, clinical, and psychosocial predictors of exercise intervention adherence in the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trials. METHODS: A total of 947 adults with dysl ...
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Journal articleFront Sports Act Living · 2023
PURPOSE: To determine if race and sex differences exist in determinants and timing of dropout among individuals enrolled in an exercise and/or caloric restriction intervention. METHODS: A total of 947 adults with dyslipidemia (STRRIDE I, STRRIDE AT/RT) or ...
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Journal articleFront Physiol · 2023
The purpose of this secondary analysis was to determine what portion of the effects of a Diabetes Prevention Program-like intervention on metabolic syndrome (MetS) could be achieved with exercise alone, as well as to determine the relative importance of ex ...
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Journal articleFront Aging · 2023
Introduction: Klotho is a protein associated with protection from aging-related diseases and health conditions. Obesity is associated with lower Klotho concentrations. Thus, this secondary analysis of adults with obesity examined 1) the change in serum Klo ...
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Journal articleSports Med Open · July 14, 2022
As type 2 diabetes remains a leading cause of morbidity and mortality, identifying the most appropriate preventive treatment early in the development of disease is an important public health matter. In general, lifestyle interventions incorporating exercis ...
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Journal articleBMJ Open Diabetes Res Care · January 2022
INTRODUCTION: To determine the relative contributions of various amounts and intensities of exercise alone to a combined lifestyle intervention on health-related quality of life (HrQoL) measures. RESEARCH DESIGN AND METHODS: Participants (n=162) were seden ...
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Journal articleTransl J Am Coll Sports Med · 2022
PURPOSE: This study aimed to characterize the timing and self-reported determinants of exercise dropout among sedentary adults with overweight or obesity. We also sought to explore variations in adherence among individuals who completed a 6- to 8-month str ...
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Journal articleObesity (Silver Spring) · March 2021
OBJECTIVE: This study examined the feasibility and comparison of two styles of yoga within the context of a standard behavioral weight-loss intervention (SBWI). METHODS: Fifty adults with obesity (BMI: 31.3 ± 3.8 kg/m2 ) participated in this 6-month study ...
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Journal articleFront Sports Act Living · 2020
Purpose: The main purpose of this study was to determine the differential effects of aerobic training (AT), resistance training (RT), and a combination of aerobic and resistance training (AT/RT) on changes in self-rated HrQoL measures, including the Short- ...
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Journal articleTranslational Journal of the American College of Sports Medicine · 2020
ABSTRACTCommercial programs are effective for reducing body weight and cardiometabolic risk factors. However, there are limited data on the additional health benefits that may result from weight loss achieved thr ...
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Journal articleMed Sci Sports Exerc · June 2019
PURPOSE: To conduct a systematic literature review to determine if physical activity is associated with prevention of weight gain in adults. METHODS: The primary literature search was conducted for the 2018 Physical Activity Guidelines Advisory Committee a ...
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Journal articleClin Chem · January 2018
BACKGROUND: Overweight and obesity are significant public health concerns that are linked to numerous negative health consequences. Physical activity is an important lifestyle behavior that contributes to body weight regulation. CONTENT: Physical activity ...
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