Katherine J. Franz | Scholars@Duke

Katherine J. Franz
Alexander F. Hehmeyer Professor of Chemistry

Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use a combination of synthesis, spectroscopy, and biochemistry in our work. Please visit our group website to learn more about our research.

Current Appointments & Affiliations

Alexander F. Hehmeyer Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2015 - 2019
Chair of the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
Professor in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2015

Contact Information

2103 French Science Center, 124 Science Drive, Durham, NC 27708
90346, Dept Of Chemistry, 124 Science Dr., Durham, NC 27708-0346
katherine.franz@duke.edu (919) 660-1541
Franz Research Group

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2000
- B.A., Wellesley College 1995
Duke Appointment History
- Associate Chair in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2016
- Associate Professor in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2010 - 2015
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2003 - 2010
Recognition
In the News
- NOV 22, 2013 Duke Research Blog
  
  Not Your Mama's Chem Lab: Energy Science in the French Center Basement
Awards & Honors
- Sloan Research Fellowship-Chemistry. Alfred P. Sloan Foundation. 2008
- Faculty Early Career Development (CAREER) Program. National Science Foundation. 2005
Research
Selected Grants
- Metals, Drugs and Fungal Pathogens awarded by National Institutes of Health 2008 - 2022
- Elucidating the Reactive Species Responsible for the Antifungal Activity of a Metallopeptide awarded by National Science Foundation 2018 - 2021
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Mapping the Fundamentals of Coordination Chemistry onto Mechanically Activated Pathways awarded by American Chemical Society 2017 - 2019
- GAANN - Department of Chemistry awarded by Department of Education 2015 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Molecular Mycology and Pathogenesis Training Program awarded by National Institutes of Health 2002 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
- Acquisition of a MALDI-TOF Mass Spectrometer System at Duke University awarded by North Carolina Biotechnology Center 2017 - 2018
- Stimulus-Responsive Agents For Manipulating Cellular Copper awarded by National Science Foundation 2012 - 2016
- REU Site: Chemistry and Applications of Smart Molecules and Materials at Duke University awarded by National Science Foundation 2011 - 2016
- Structural Biology and Biophysics Training Program awarded by National Institutes of Health 1994 - 2015
- BioMetals 2014 Conference at Duke University awarded by National Institutes of Health 2014 - 2015
- High sensitivity multi-purpose electron paramagnetic resonance spectroscopy for biotechnological and biomedical research awarded by North Carolina Biotechnology Center 2014 - 2015
- Purchase of a Q-TOF LC/MS System awarded by National Institutes of Health 2010 - 2011
- Metal-Binding Studies of Phosporylated alpha-Synuclein Peptides awarded by National Science Foundation 2005 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Franz, KJ, and Metzler-Nolte, N. "Introduction: Metals in Medicine." Chemical Reviews 119, no. 2 (January 23, 2019): 727-729. Full Text
  - Franz, KJ. "Metallomics: Emerging Investigators 2019." Metallomics : Integrated Biometal Science 11, no. 1 (January 2019): 9-14. Full Text
  - Wang, Q, and Franz, KJ. "Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress." Bioorganic & Medicinal Chemistry 26, no. 22 (December 2018): 5962-5972. Full Text
  - Bakthavatsalam, S, Sleeper, ML, Dharani, A, George, DJ, Zhang, T, and Franz, KJ. "Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells." Angewandte Chemie (International Ed. in English) 57, no. 39 (September 2018): 12780-12784. Full Text
  - Zaengle-Barone, JM, Jackson, AC, Besse, DM, Becken, B, Arshad, M, Seed, PC, and Franz, KJ. "Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria." Acs Infectious Diseases 4, no. 6 (June 2018): 1019-1029. Full Text
  - Hall, KC, Franks, AT, McAtee, RC, Wang, MS, Lu, VI, and Franz, KJ. "Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics." Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 16, no. 11 (November 2017): 1604-1612. Full Text
  - Wang, Q, and Franz, KJ. "The hydrolytic susceptibility of prochelator BSIH in aqueous solutions." Bioorganic & Medicinal Chemistry Letters 27, no. 17 (September 2017): 4165-4170. Full Text
  - Conklin, SE, Bridgman, EC, Su, Q, Riggs-Gelasco, P, Haas, KL, and Franz, KJ. "Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans." Biochemistry 56, no. 32 (August 2017): 4244-4255. Full Text Open Access Copy
  - Helsel, ME, White, EJ, Razvi, SZA, Alies, B, and Franz, KJ. "Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans." Metallomics : Integrated Biometal Science 9, no. 1 (January 2017): 69-81. Full Text
  - Sansee, A, Meksawangwong, S, Chainok, K, Franz, KJ, Gál, M, Pålsson, L-O, Puniyan, W, Traiphol, R, Pal, R, and Kielar, F. "Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains." Dalton Transactions (Cambridge, England : 2003) 45, no. 43 (November 2016): 17420-17430. Full Text
  - Wang, Q, and Franz, KJ. "Stimulus-Responsive Prochelators for Manipulating Cellular Metals." Accounts of Chemical Research 49, no. 11 (November 2016): 2468-2477. Full Text
  - Hašková, P, Jansová, H, Bureš, J, Macháček, M, Jirkovská, A, Franz, KJ, Kovaříková, P, and Šimůnek, T. "Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury." Toxicology 371 (September 2016): 17-28. Full Text
  - Jansová, H, Bureš, J, Macháček, M, Hašková, P, Jirkovská, A, Roh, J, Wang, Q, Franz, KJ, Kovaříková, P, and Šimůnek, T. "Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products." Toxicology 350-352 (March 2016): 15-24. Full Text
  - Franks, AT, Wang, Q, and Franz, KJ. "A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress." Bioorganic & Medicinal Chemistry Letters 25, no. 21 (November 2015): 4843-4847. Full Text
  - Pushie, MJ, Shaw, K, Franz, KJ, Shearer, J, and Haas, KL. "Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1." Inorganic Chemistry 54, no. 17 (September 2015): 8544-8551. Full Text
  - Alies, B, Wiener, JD, and Franz, KJ. "A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity." Chemical Science 6, no. 6 (June 2015): 3606-3610. Full Text
  - Crumbliss, AL, Franz, KJ, and Thiele, DJ. "Preface." Biometals 28, no. 3 (June 2015): 431-431. Full Text
  - Crumbliss, AL, Franz, KJ, and Thiele, DJ. "Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA." Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 28, no. 3 (June 2015): 431-null. Full Text
  - Helsel, ME, and Franz, KJ. "Pharmacological activity of metal binding agents that alter copper bioavailability." Dalton Transactions (Cambridge, England : 2003) 44, no. 19 (May 2015): 8760-8770. Full Text
  - Bureš, J, Jansová, H, Stariat, J, Filipský, T, Mladěnka, P, Šimůnek, T, Kučera, R, Klimeš, J, Wang, Q, Franz, KJ, and Kovaříková, P. "LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)." Journal of Pharmaceutical and Biomedical Analysis 105 (February 2015): 55-63. Full Text
  - Franks, AT, Wang, Q, and Franz, KJ. "A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress." Bioorganic and Medicinal Chemistry Letters 25, no. 21 (2015): 4843-4847. Full Text
  - Franks, AT, and Franz, KJ. "A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting." Chemical communications (Cambridge, England) 50, no. 77 (October 2014): 11317-11320. Full Text
  - Safi, R, Nelson, ER, Chitneni, SK, Franz, KJ, George, DJ, Zalutsky, MR, and McDonnell, DP. "Copper signaling axis as a target for prostate cancer therapeutics." Cancer Research 74, no. 20 (October 2014): 5819-5831. Full Text Open Access Copy
  - Jansová, H, Macháček, M, Wang, Q, Hašková, P, Jirkovská, A, Potůčková, E, Kielar, F, Franz, KJ, and Simůnek, T. "Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury." Free Radical Biology & Medicine 74 (September 2014): 210-221. Full Text
  - Festa, RA, Helsel, ME, Franz, KJ, and Thiele, DJ. "Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection." Chemistry & Biology 21, no. 8 (August 2014): 977-987. Full Text
  - Festa, RA, Helsel, ME, Franz, KJ, and Thiele, DJ. "Innate immune cell activation of a copper-dependent anti-cryptococcal agent." MYCOSES 57 (May 2014): 56-57. Link to Item
  - Franks, AT, Peng, D, Yang, W, and Franz, KJ. "Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties." Inorganic Chemistry 53, no. 3 (February 2014): 1397-1405. Full Text
  - Folk, DS, Kielar, F, and Franz, KJ. "Bioinorganic Neurochemistry." 3 (August 1, 2013): 207-240. (Chapter) Full Text
  - Grant, GA, Hankinson, T, Muh, C, and Dumont, A. "The 62nd Annual Meeting of the Congress of Neurological Surgeons was held in Chicago, Illinois from October 6-10, 2012. Preface." Neurosurgery 60 Suppl 1 (August 2013): v-. Full Text
  - Franz, KJ. "Clawing back: broadening the notion of metal chelators in medicine." Current Opinion in Chemical Biology 17, no. 2 (April 2013): 143-149. (Review) Full Text
  - Kumbhar, AA, Franks, AT, Butcher, RJ, and Franz, KJ. "Light uncages a copper complex to induce nonapoptotic cell death." Chem Commun (Camb) 49, no. 24 (March 25, 2013): 2460-2462. Full Text Link to Item
  - Franz, KJ. "Clawing back: Broadening the notion of metal chelators in medicine." Current Opinion in Chemical Biology 17, no. 2 (2013): 143-149. Full Text
  - Kielar, F, Wang, Q, Boyle, PD, and Franz, KJ. "A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding." Inorganica Chimica Acta 393 (December 2012): 294-303. Full Text
  - Folk, DS, Torosian, JC, Hwang, S, McCafferty, DG, and Franz, KJ. "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe." Angew Chem Int Ed Engl 51, no. 43 (October 22, 2012): 10795-10799. Full Text Link to Item
  - Hyman, LM, and Franz, KJ. "Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols." Coordination Chemistry Reviews 256, no. 19-20 (October 2012): 2333-2356. Full Text
  - Kielar, F, Helsel, ME, Wang, Q, and Franz, KJ. "Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation." Metallomics : Integrated Biometal Science 4, no. 9 (August 2012): 899-909. Full Text
  - Rubino, JT, and Franz, KJ. "Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function." Journal of Inorganic Biochemistry 107, no. 1 (February 2012): 129-143. (Review) Full Text
  - Hyman, LM, and Franz, KJ. "A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence." Inorganica Chim Acta 380 (January 15, 2012): 125-134. Full Text Link to Item
  - Franz, KJ. "Application of inorganic chemistry for non-cancer therapeutics." Dalton Transactions 41, no. 21 (2012): 6333-6334. Full Text
  - Leed, MGD, Wolkow, N, Pham, DM, Daniel, CL, Dunaief, JL, and Franz, KJ. "Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress." J Inorg Biochem 105, no. 9 (September 2011): 1161-1172. Full Text Link to Item
  - Haas, KL, Putterman, AB, White, DR, Thiele, DJ, and Franz, KJ. "Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1." Journal of the American Chemical Society 133, no. 12 (March 4, 2011): 4427-4437. Full Text
  - Ciesienski, KL, and Franz, KJ. "Keys for unlocking photolabile metal-containing cages." Angew Chem Int Ed Engl 50, no. 4 (January 24, 2011): 814-824. (Review) Full Text Link to Item
  - Rubino, JT, Chenkin, MP, Keller, M, Riggs-Gelasco, P, and Franz, KJ. "A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments." Metallomics 3, no. 1 (January 2011): 61-73. Link to Item
  - Rubino, JT, Chenkin, MP, Keller, M, Riggs-Gelasco, P, and Franz, KJ. "A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments." Metallomics 3, no. 1 (January 2011): 61-73. Full Text Link to Item
  - Ciesienski, KL, Haas, KL, and Franz, KJ. "Development of next-generation photolabile copper cages with improved copper binding properties." Dalton Trans 39, no. 40 (October 28, 2010): 9538-9546. Full Text Open Access Copy Link to Item
  - Rubino, JT, Riggs-Gelasco, P, and Franz, KJ. "Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I)." J Biol Inorg Chem 15, no. 7 (September 2010): 1033-1049. Full Text Link to Item
  - Ciesienski, KL, Hyman, LM, Derisavifard, S, and Franz, KJ. "Toward the detection of cellular copper(II) by a light-activated fluorescence increase." Inorg Chem 49, no. 15 (August 2, 2010): 6808-6810. Full Text Open Access Copy Link to Item
  - Ciesienski, KL, Hyman, LM, Yang, DT, Haas, KL, Dickens, MG, Holbrook, RJ, and Franz, KJ. "A photo-caged platinum(II) complex that increases cytotoxicity upon light activation." European Journal of Inorganic Chemistry , no. 15 (May 1, 2010): 2224-2228. Full Text
  - Folk, DS, and Franz, KJ. "A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation." Journal of the American Chemical Society 132, no. 14 (April 2010): 4994-4995. Full Text Open Access Copy
  - Perez, LR, and Franz, KJ. "Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease." Dalton Trans 39, no. 9 (March 7, 2010): 2177-2187. Full Text Open Access Copy Link to Item
  - Tangen, E, Conradie, J, Franz, K, Friedle, S, Telser, J, Lippard, SJ, and Ghosh, A. "Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand." Inorganic Chemistry 49, no. 6 (March 2010): 2701-2705. Full Text
  - Hyman, LM, Stephenson, CJ, Dickens, MG, Shimizu, KD, and Franz, KJ. "Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress." Dalton Trans , no. 2 (January 14, 2010): 568-576. Full Text Link to Item
  - Dickens, MG, and Franz, KJ. "A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation." Chembiochem 11, no. 1 (January 4, 2010): 59-62. Full Text Link to Item
  - Crider, SE, Holbrook, RJ, and Franz, KJ. "Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1." Metallomics : Integrated Biometal Science 2, no. 1 (January 2010): 74-83. Full Text Open Access Copy
  - Franz, KJ, and He, C. "The highways and byways of bioinorganic chemistry." Current Opinion in Chemical Biology 14, no. 2 (2010): 208-210. Full Text
  - Haas, KL, and Franz, KJ. "Application of metal coordination chemistry to explore and manipulate cell biology." Chemical Reviews 109, no. 10 (October 2009): 4921-4960. (Review) Full Text
  - Palmer, AE, and Franz, KJ. "Introduction to cellular metal homeostasis and trafficking." Chemical Reviews 109, no. 10 (2009): 4533-4535. Full Text
  - Charkoudian, LK, Dentchev, T, Lukinova, N, Wolkow, N, Dunaief, JL, and Franz, KJ. "Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide." J Inorg Biochem 102, no. 12 (December 2008): 2130-2135. Full Text Link to Item
  - Ciesienski, KL, Haas, KL, Dickens, MG, Tesema, YT, and Franz, KJ. "A photolabile ligand for light-activated release of caged copper." J Am Chem Soc 130, no. 37 (September 17, 2008): 12246-12247. Full Text Link to Item
  - Tesema, YT, Pham, DM, and Franz, KJ. "Counterions influence reactivity of metal ions with cysteinyldopa model compounds." Inorg Chem 47, no. 3 (February 4, 2008): 1087-1095. Full Text Link to Item
  - Franz, KJ. "Copper shares a piece of the π." Nature Chemical Biology 4, no. 2 (2008): 85-86. Full Text
  - Charkoudian, LK, Pham, DM, Kwon, AM, Vangeloff, AD, and Franz, KJ. "Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress." Dalton Trans , no. 43 (November 21, 2007): 5031-5042. Full Text Link to Item
  - Liu, LL, and Franz, KJ. "Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments." J Biol Inorg Chem 12, no. 2 (February 2007): 234-247. Full Text Link to Item
  - Charkoudian, LK, Pham, DM, and Franz, KJ. "A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation." J Am Chem Soc 128, no. 38 (September 27, 2006): 12424-12425. Full Text Link to Item
  - Tesema, YT, Pham, DM, and Franz, KJ. "Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin." Inorg Chem 45, no. 16 (August 7, 2006): 6102-6104. Full Text Link to Item
  - Charkoudian, LK, and Franz, KJ. "Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid." Inorganic Chemistry 45, no. 9 (May 2006): 3657-3664. Full Text
  - Jiang, J, Nadas, IA, Kim, MA, and Franz, KJ. "A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination." Inorg Chem 44, no. 26 (December 26, 2005): 9787-9794. Full Text Link to Item
  - Liu, LL, and Franz, KJ. "Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding." J Am Chem Soc 127, no. 27 (July 13, 2005): 9662-9663. Full Text Link to Item
  - Nitz, M, Sherawat, M, Franz, KJ, Peisach, E, Allen, KN, and Imperiali, B. "Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide." Angewandte Chemie (International Ed. in English) 43, no. 28 (July 2004): 3682-3685. Full Text
  - Franz, KJ, Nitz, M, and Imperiali, B. "Lanthanide-binding tags as versatile protein coexpression probes." Chembiochem : a European Journal of Chemical Biology 4, no. 4 (April 2003): 265-271. Full Text
  - Nitz, M, Franz, KJ, Maglathlin, RL, and Imperiali, B. "A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides." ChemBioChem 4, no. 4 (2003): 272-276. Full Text
  - Wöhnert, J, Franz, KJ, Nitz, M, Imperiali, B, and Schwalbe, H. "Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings." Journal of the American Chemical Society 125, no. 44 (2003): 13338-13339. Full Text
  - Franz, KJ, Doerrer, LH, Spingler, B, and Lippard, SJ. "Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds." INORGANIC CHEMISTRY 40, no. 15 (July 16, 2001): 3774-3780. Full Text Link to Item
  - Franz, KJ, Doerrer, LH, Spingler, B, and Lippard, SJ. "Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds." Inorganic Chemistry 40, no. 15 (2001): 3774-3780. Full Text
  - Franz, KJ, Singh, N, Spingler, B, and Lippard, SJ. "Aminotroponiminates as ligands for potential metal-based nitric oxide sensors." Inorganic Chemistry 39, no. 18 (September 2000): 4081-4092. Full Text
  - Franz, KJ, Singh, N, and Lippard, SJ. "Metal-based NO sensing by selective ligand dissociation." Angewandte Chemie International Edition 39, no. 12 (June 16, 2000): 2120-2122. Full Text
  - Franz, KJ, Singh, N, and Lippard, SJ. "Metal-based NO sensing by selective ligand dissociation." Angewandte Chemie International Edition 39, no. 12 (2000): 2120-2122. Full Text
  - Franz, KJ, and Lippard, SJ. "Nitrosyl transfer from manganese to iron in tropocoronand complexes." Inorganic Chemistry 39, no. 16 (2000): 3722-3723. Full Text
  - Franz, KJ, and Lippard, SJ. "NO disproportionation reactivity of Fe tropocoronand complexes." Journal of the American Chemical Society 121, no. 45 (November 17, 1999): 10504-10512. Full Text
  - Franz, KJ, Lippard, SJ, Marlin, D, and Mascharak, P. "Disproportionation of nitric oxide promoted by a Mn tropocoronand." Chemtracts 12, no. 2 (February 1, 1999): 135-140.
  - Loehlin, JH, Franz, KJ, Gist, L, and Moore, RH. "Supramolecular Alcohol–Amine Crystals and Their Hydrogen-Bond Patterns." Acta Crystallographica Section B Structural Science 54, no. 5 (October 1, 1998): 695-704. Full Text
  - Franz, KJ, and Lippard, SJ. "Disproportionation of nitric oxide promoted by a Mn tropocoronand." Journal of the American Chemical Society 120, no. 35 (September 9, 1998): 9034-9040. Full Text
  - Huang, SP, Franz, KJ, Arnold, EH, Devenyi, J, and Fish, RH. "Polymer pendant ligand chemistry-5. The selective and competitive removal of Ag⁺, Hg²⁺, Cu²⁺, Pb²⁺and Cd²⁺ions from aqueous solution utilizing a N-sulfonylethylenebis(dithiocarbamate) ligand anchored on macroporous polystyrene-divinylbenzene beads." Polyhedron 15, no. 23 (September 6, 1996): 4241-4254. Full Text
  - Huang, SP, Franz, KJ, Olmstead, MM, and Fish, RH. "Synthetic and Structural Studies of a Linear Bis-Catechol Amide, N,N′-Bis(2,3-dihydroxybenzoyl)-1,7-diazaheptane (5-LICAM), and Its Complexes with Ni²⁺ and Co²⁺: Utilization of a Polymer-Supported, Sulfonated Analog, 5-LICAMS, as a Biomimetic Ligand for Divalent Metal Ion Removal from Aqueous Solution." Inorganic Chemistry 34, no. 11 (May 1, 1995): 2820-2825. Full Text
  - Huang, SP, Li, W, Franz, KJ, Albright, RL, and Fish, RH. "Polymer Pendant Ligand Chemistry. 3. A Biomimetic Approach to Selective Metal Ion Removal and Recovery from Aqueous Solution with Polymer-Supported Sulfonated Catechol and Linear Catechol Amide Ligands." Inorganic Chemistry 34, no. 11 (May 1, 1995): 2813-2819. Full Text
- Book Sections
  - Wang, Q, and Franz, KJ. "Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes." In Inorganic Chemical Biology: Principles, Techniques and Applications, 233-274. June 23, 2014. Full Text
- Conference Papers
  - Franz, KJ. "Chemical Approaches for Manipulating Microbial Metals." July 2017. Link to Item
  - Franz, KJ. "Manipulating metals at the host-pathogen interface." March 16, 2014. Link to Item
  - Franks, A, Helsel, M, and Franz, KJ. "Development of stimulus-responsive metal chelation with novel fluorescence reporting." April 7, 2013. Link to Item
  - Folk, DS, Torosian, J, and Franz, KJ. "BACE activated prochelator mediates A beta-Cu toxicity in an Alzheimer's disease cell model." March 25, 2012. Link to Item
  - Franz, KJ. "Optimizing prochelators to bind metal ions in response to disease-associated stimuli[p]." March 25, 2012. Link to Item
  - Zielonka, J, Kielar, F, Sikora, A, Franz, KJ, and Kalyanaraman, B. "Dual Antioxidant Activity of Boronate-Based Prochelators: Scavenging Peroxynitrite and Metal Ion Chelation." : Elsevier BV, November 2011. Full Text
  - Franz, KJ. "Design of prochelators that bind cellular metal ions in response to diverse stimuli." August 28, 2011. Link to Item
  - Franz, KJ, and Haas, KL. "Insights into the role of histidine in Ctr1-dependent copper uptake." August 22, 2010. Link to Item
  - Hyman, LM, and Franz, KJ. "Development of triggereable chelating agents as probes for metal-induced oxidative stress." August 22, 2010. Link to Item
  - Franz, KJ. "Recent developments in the design of triggerable chelating agents for altering metal coordination in biological settings." March 21, 2010. Link to Item
  - Dickens, MG, Daniel, CL, Pham, DM, and Franz, KJ. "Synthesis of masked bidentate and hexadentate iron chelators designed to reduce oxidative stress." August 16, 2009. Link to Item
  - Franz, KJ. "Design of triggerable ligands for altering metal coordination in biological settings." August 16, 2009. Link to Item
  - Haas, KL, White, DR, and Franz, KJ. "Spectroscopic studies of N-terminal Cu(II)- and Cu(I)-binding hCtrl model peptides." August 16, 2009. Link to Item
  - Rubino, JT, and Franz, KJ. "Characterization of thioether-only Cu(I) binding by Ctr1 methionine motifs." August 16, 2009. Link to Item
  - Ciesienski, KL, Haas, KL, Dickens, MG, and Franz, KJ. "Photolabile ligand for light-activated release of caged copper." March 22, 2009. Link to Item
  - Crider, SE, and Franz, KJ. "INOR 277-Interactions of cisplatin and methionine-rich peptide domains of the human high-affinity copper transporter Ctr1." April 6, 2008. Link to Item
  - Hunt, LM, and Franz, KJ. "INOR 273-Development of prochelators as probes of iron-induced oxidative stress." April 6, 2008. Link to Item
  - Franz, KJ, and Charkoudian, LK. "INOR 916-A pro-chelator strategy for inhibiting metal-catalyzed oxidative stress." August 19, 2007. Link to Item
  - Charkoudian, LK, and Franz, KJ. "INOR 614-Development of iron chelators triggered by reactive oxygen species." September 10, 2006. Link to Item
  - Franz, KJ, Haas, K, Rubino, J, and Pham, D. "INOR 1011-Copper(I) binding by methionine-rich domains of copper transport proteins." September 10, 2006. Link to Item
  - Liu, LL, and Franz, KJ. "Characterization of metal binding sites in a synthetic phosphorylated alpha-synuclein peptide fragment." March 13, 2005. Link to Item
  - Franz, KJ, Nitz, M, Lukovic, E, and Imperiali, B. "Development of lanthanide-binding peptides as natively expressed protein probes." July 2003. Full Text
Teaching & Mentoring
Recent Courses
- CHEM 393: Research Independent Study 2019
- CHEM 394: Research Independent Study 2019
- CHEM 493: Research Independent Study 2019
- CHEM 494: Research Independent Study 2019
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Service to the Profession

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses

Presentations & Appearances

Service to the Profession