Katherine J. Franz
Chair of the Department of Chemistry
Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use a combination of synthesis, spectroscopy, and biochemistry in our work. Please visit our group website to learn more about our research.
Current Appointments & Affiliations
- Chair of the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2017
- Professor in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
Contact Information
- 2103 French Science Center, 124 Science Drive, Durham, NC 27708
- 90346, Dept of Chemistry, 124 Science Dr., Durham, NC 27708-0346
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katherine.franz@duke.edu
(919) 660-1541
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Franz Research Group
- Background
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Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2000
- B.A., Wellesley College 1995
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Previous Appointments & Affiliations
- Alexander F. Hehmeyer Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2015 - 2019
- Associate Chair in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2016
- Associate Professor in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2010 - 2015
- Alexander F. Hehmeyer Associate Professor, Chemistry, Trinity College of Arts & Sciences 2014 - 2015
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2003 - 2010
- Recognition
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In the News
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APR 17, 2020 -
AUG 27, 2019 -
NOV 22, 2013 Duke Research Blog
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Awards & Honors
- Southern Chemists Award. Memphis Section of the American Chemical Society. 2022
- Charles H. Stone Award. Carolina Piedmont Section of the American Chemical Society. 2021
- ACS National Award for Encouraging Women in the Chemical Sciences. American Chemical Society. 2020
- Dean’s Diversity Award. Trinity College of Arts & Sciences, Duke University. 2020
- Dean’s Award for Excellence in Mentoring. Duke University Graduate School. 2016
- Camille Dreyfus Teacher-Scholar Award. The Camille and Henry Dreyfus Foundation. 2009
- Sloan Research Fellowship-Chemistry. Alfred P. Sloan Foundation. 2008
- Faculty Early Career Development (CAREER) Program. National Science Foundation. 2005
- Expertise
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Subject Headings
- Research
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Selected Grants
- Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program awarded by National Institutes of Health 2022 - 2027
- What Does This Goo Do With Cu? Discovery of a Specific Copper Binding Site in Gel-Forming Mucins awarded by US-Israel Binational Science Foundation 2022 - 2026
- Elucidating the Molecular Basis of Cellular Metal Stress by using Mass Spectrometry-Based Proteomic Methods awarded by National Institutes of Health 2022 - 2026
- MRI: Acquisition of a Microscale Thermophoresis System awarded by National Science Foundation 2022 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Duke University Program in Environmental Health awarded by National Institutes of Health 2019 - 2024
- Metals, Drugs and Fungal Pathogens awarded by National Institutes of Health 2008 - 2023
- Elucidating the Reactive Species Responsible for the Antifungal Activity of a Metallopeptide awarded by National Science Foundation 2018 - 2022
- Mapping the Fundamentals of Coordination Chemistry onto Mechanically Activated Pathways awarded by American Chemical Society 2017 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- GAANN - Department of Chemistry awarded by Department of Education 2015 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
- Acquisition of a MALDI-TOF Mass Spectrometer System at Duke University awarded by North Carolina Biotechnology Center 2017 - 2018
- Stimulus-Responsive Agents For Manipulating Cellular Copper awarded by National Science Foundation 2012 - 2016
- REU Site: Chemistry and Applications of Smart Molecules and Materials at Duke University awarded by National Science Foundation 2011 - 2016
- Structural Biology and Biophysics Training Program awarded by National Institutes of Health 1994 - 2015
- BioMetals 2014 Conference at Duke University awarded by National Institutes of Health 2014 - 2015
- High sensitivity multi-purpose electron paramagnetic resonance spectroscopy for biotechnological and biomedical research awarded by North Carolina Biotechnology Center 2014 - 2015
- Purchase of a Q-TOF LC/MS System awarded by National Institutes of Health 2010 - 2011
- Metal-Binding Studies of Phosporylated alpha-Synuclein Peptides awarded by National Science Foundation 2005 - 2010
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Fellowships, Supported Research, & Other Grants
- Seed Grant: MentorUp/MentorDown: Interactive workshops to strengthen mentoring relationships awarded by Duke Office of Faculty Advancement 2018
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External Relationships
- Alexion Pharmaceuticals, Inc.
- editorial board for Metallomics, a journal of the Oxford University Press
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Gao, Sean, Joanna X. Campbell, Terrence G. Oas, and Katherine J. Franz. “Multiple Modes of Zinc Binding to Histatin 5 Revealed by Buffer-Independent Thermodynamics.” Inorg Chem 62, no. 18 (May 8, 2023): 7087–96. https://doi.org/10.1021/acs.inorgchem.3c00608.Full Text Link to Item
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Robison, Amy T. R., Grace R. Sturrock, Jacqueline M. Zaengle-Barone, Nancy Wiebelhaus, Azim Dharani, Isabella G. Williams, Michael C. Fitzgerald, and Katherine J. Franz. “Analysis of copper-induced protein precipitation across the E. coli proteome.” Metallomics : Integrated Biometal Science 15, no. 1 (January 2023): mfac098. https://doi.org/10.1093/mtomcs/mfac098.Full Text
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Reznik, Nava, Annastassia D. Gallo, Katherine W. Rush, Gabriel Javitt, Yael Fridmann-Sirkis, Tal Ilani, Noa A. Nairner, et al. “Intestinal mucin is a chaperone of multivalent copper.” Cell 185, no. 22 (October 2022): 4206-4215.e11. https://doi.org/10.1016/j.cell.2022.09.021.Full Text
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Campbell, Joanna X., Sean Gao, Keerthi S. Anand, and Katherine J. Franz. “Zinc Binding Inhibits Cellular Uptake and Antifungal Activity of Histatin-5 in Candida albicans.” Acs Infectious Diseases 8, no. 9 (September 2022): 1920–34. https://doi.org/10.1021/acsinfecdis.2c00289.Full Text
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Hašková, Pavlína, Lenka Applová, Hana Jansová, Pavel Homola, Katherine J. Franz, Kateřina Vávrová, Jaroslav Roh, and Tomáš Šimůnek. “Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine.” Scientific Reports 12, no. 1 (June 2022): 9765. https://doi.org/10.1038/s41598-022-13554-x.Full Text
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Zhang, Tian, Julie Kephart, Elizabeth Bronson, Monika Anand, Christine Daly, Ivan Spasojevic, Subha Bakthavatsalam, et al. “Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer.” Prostate 82, no. 7 (May 2022): 858–66. https://doi.org/10.1002/pros.24329.Full Text Link to Item
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Ge, Eva J., Ashley I. Bush, Angela Casini, Paul A. Cobine, Justin R. Cross, Gina M. DeNicola, Q Ping Dou, et al. “Connecting copper and cancer: from transition metal signalling to metalloplasia.” Nature Reviews. Cancer 22, no. 2 (February 2022): 102–13. https://doi.org/10.1038/s41568-021-00417-2.Full Text
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Salcedo-Sora, Jesus Enrique, Amy T. R. Robison, Jacqueline Zaengle-Barone, Katherine J. Franz, and Douglas B. Kell. “Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli.” Molecules (Basel, Switzerland) 26, no. 19 (September 2021): 5826. https://doi.org/10.3390/molecules26195826.Full Text
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Hunsaker, Elizabeth W., Chen-Hsin Albert Yu, and Katherine J. Franz. “Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress.” G3 (Bethesda, Md.) 11, no. 4 (April 2021): jkab065. https://doi.org/10.1093/g3journal/jkab065.Full Text
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Razgoniaev, Anton O., Logan M. Glasstetter, Tatiana B. Kouznetsova, Kacey C. Hall, Matias Horst, Stephen L. Craig, and Katherine J. Franz. “Single-Molecule Activation and Quantification of Mechanically Triggered Palladium-Carbene Bond Dissociation.” Journal of the American Chemical Society 143, no. 4 (February 2021): 1784–89. https://doi.org/10.1021/jacs.0c13219.Full Text
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Jackson, Abigail C., Tyler B. J. Pinter, Daniel C. Talley, Adnan Baker-Agha, Dhruvil Patel, Paul J. Smith, and Katherine J. Franz. “Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-β-Lactamase NDM-1.” Chemmedchem 16, no. 4 (February 2021): 654–61. https://doi.org/10.1002/cmdc.202000607.Full Text
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Wiebelhaus, Nancy, Jacqueline M. Zaengle-Barone, Kevin K. Hwang, Katherine J. Franz, and Michael C. Fitzgerald. “Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli.” Acs Chemical Biology 16, no. 1 (January 2021): 214–24. https://doi.org/10.1021/acschembio.0c00900.Full Text
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Hunsaker, Elizabeth W., Katherine J. McAuliffe, and Katherine J. Franz. “Fluconazole analogues with metal-binding motifs impact metal-dependent processes and demonstrate antifungal activity in Candida albicans.” Journal of Biological Inorganic Chemistry : Jbic : A Publication of the Society of Biological Inorganic Chemistry 25, no. 5 (August 2020): 729–45. https://doi.org/10.1007/s00775-020-01796-x.Full Text
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Bakthavatsalam, Subha, Petpailin Wiangnak, Daniel J. George, Tian Zhang, and Katherine J. Franz. “Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer.” Bioorg Med Chem Lett 30, no. 11 (June 1, 2020): 127148. https://doi.org/10.1016/j.bmcl.2020.127148.Full Text Link to Item
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Jackson, Abigail C., Jacqueline M. Zaengle-Barone, Elena A. Puccio, and Katherine J. Franz. “A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-lactamase 1 without Removing Zinc.” Acs Infectious Diseases 6, no. 5 (May 2020): 1264–72. https://doi.org/10.1021/acsinfecdis.0c00083.Full Text
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Gallo, Annastassia D., and Katherine J. Franz. “Grab 'n Go: Siderophore-Binding Proteins Provide Pathogens a Quick Fix to Satisfy Their Hunger for Iron.” Acs Central Science 6, no. 4 (April 2020): 456–58. https://doi.org/10.1021/acscentsci.0c00179.Full Text
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Zaengle-Barone, Jacqueline M., Abigail C. Jackson, David M. Besse, Bradford Becken, Mehreen Arshad, Patrick C. Seed, and Katherine J. Franz. “Correction to Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.” Acs Infectious Diseases 6, no. 4 (April 2020): 759. https://doi.org/10.1021/acsinfecdis.0c00082.Full Text
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Garcia-Santamarina, Sarela, Corinna Probst, Richard A. Festa, Chen Ding, Aaron D. Smith, Steven E. Conklin, Søren Brander, et al. “A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis.” Nature Chemical Biology 16, no. 3 (March 2020): 337–44. https://doi.org/10.1038/s41589-019-0437-9.Full Text
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Hunsaker, Elizabeth W., and Katherine J. Franz. “Candida albicans reprioritizes metal handling during fluconazole stress.” Metallomics : Integrated Biometal Science 11, no. 12 (December 2019): 2020–32. https://doi.org/10.1039/c9mt00228f.Full Text
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Hunsaker, Elizabeth W., and Katherine J. Franz. “Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit.” Inorganic Chemistry 58, no. 20 (October 2019): 13528–45. https://doi.org/10.1021/acs.inorgchem.9b01029.Full Text
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Hunsaker, Elizabeth W., and Katherine J. Franz. “Copper potentiates azole antifungal activity in a way that does not involve complex formation.” Dalton Transactions (Cambridge, England : 2003) 48, no. 26 (July 2019): 9654–62. https://doi.org/10.1039/c9dt00642g.Full Text
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Franz, Katherine J. “Metallomics: Emerging Investigators 2019.” Metallomics : Integrated Biometal Science 11, no. 1 (January 2019): 9–14. https://doi.org/10.1039/c8mt90047g.Full Text
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Franz, Katherine J., and Nils Metzler-Nolte. “Introduction: Metals in Medicine.” Chemical Reviews 119, no. 2 (January 2019): 727–29. https://doi.org/10.1021/acs.chemrev.8b00685.Full Text
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Wang, Qin, and Katherine J. Franz. “Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress.” Bioorganic & Medicinal Chemistry 26, no. 22 (December 2018): 5962–72. https://doi.org/10.1016/j.bmc.2018.11.004.Full Text
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Bakthavatsalam, Subha, Mark L. Sleeper, Azim Dharani, Daniel J. George, Tian Zhang, and Katherine J. Franz. “Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells.” Angew Chem Int Ed Engl 57, no. 39 (September 24, 2018): 12780–84. https://doi.org/10.1002/anie.201807582.Full Text Link to Item
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Zaengle-Barone, Jacqueline M., Abigail C. Jackson, David M. Besse, Bradford Becken, Mehreen Arshad, Patrick C. Seed, and Katherine J. Franz. “Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.” Acs Infect Dis 4, no. 6 (June 8, 2018): 1019–29. https://doi.org/10.1021/acsinfecdis.8b00037.Full Text Link to Item
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Hall, Kacey C., Andrew T. Franks, Rory C. McAtee, Michael S. Wang, Vivian I. Lu, and Katherine J. Franz. “Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics.” Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology 16, no. 11 (November 2017): 1604–12. https://doi.org/10.1039/c7pp00173h.Full Text
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Wang, Qin, and Katherine J. Franz. “The hydrolytic susceptibility of prochelator BSIH in aqueous solutions.” Bioorganic & Medicinal Chemistry Letters 27, no. 17 (September 2017): 4165–70. https://doi.org/10.1016/j.bmcl.2017.07.019.Full Text
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Conklin, S. E., E. C. Bridgman, Q. Su, P. Riggs-Gelasco, and K. J. Franz. “Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.” Biochemistry, August 1, 2017. https://doi.org/10.1021/acs.biochem.7b00348.Full Text Open Access Copy Link to Item
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Helsel, Marian E., Elizabeth J. White, Sayyeda Zeenat A. Razvi, Bruno Alies, and Katherine J. Franz. “Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans.” Metallomics : Integrated Biometal Science 9, no. 1 (January 2017): 69–81. https://doi.org/10.1039/c6mt00172f.Full Text
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Sansee, A., S. Meksawangwong, K. Chainok, K. J. Franz, M. Gál, L. -. O. Pålsson, W. Puniyan, R. Traiphol, R. Pal, and F. Kielar. “Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains.” Dalton Transactions (Cambridge, England : 2003) 45, no. 43 (November 2016): 17420–30. https://doi.org/10.1039/c6dt02776h.Full Text
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Wang, Qin, and Katherine J. Franz. “Stimulus-Responsive Prochelators for Manipulating Cellular Metals.” Accounts of Chemical Research 49, no. 11 (November 2016): 2468–77. https://doi.org/10.1021/acs.accounts.6b00380.Full Text
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Hašková, Pavlína, Hana Jansová, Jan Bureš, Miloslav Macháček, Anna Jirkovská, Katherine J. Franz, Petra Kovaříková, and Tomáš Šimůnek. “Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.” Toxicology 371 (September 2016): 17–28. https://doi.org/10.1016/j.tox.2016.10.004.Full Text
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Jansová, Hana, Jan Bureš, Miloslav Macháček, Pavlína Hašková, Anna Jirkovská, Jaroslav Roh, Qin Wang, Katherine J. Franz, Petra Kovaříková, and Tomáš Šimůnek. “Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.” Toxicology 350–352 (March 2016): 15–24. https://doi.org/10.1016/j.tox.2016.03.004.Full Text
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Franks, Andrew T., Qin Wang, and Katherine J. Franz. “A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.” Bioorganic & Medicinal Chemistry Letters 25, no. 21 (November 2015): 4843–47. https://doi.org/10.1016/j.bmcl.2015.06.048.Full Text
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Pushie, M Jake, Katharine Shaw, Katherine J. Franz, Jason Shearer, and Kathryn L. Haas. “Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.” Inorganic Chemistry 54, no. 17 (September 2015): 8544–51. https://doi.org/10.1021/acs.inorgchem.5b01162.Full Text
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Alies, Bruno, Jacob D. Wiener, and Katherine J. Franz. “A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity.” Chemical Science 6, no. 6 (June 2015): 3606–10. https://doi.org/10.1039/c5sc00602c.Full Text
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Crumbliss, Alvin L., Katherine J. Franz, and Dennis J. Thiele. “Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA.” Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 28, no. 3 (June 2015): 431. https://doi.org/10.1007/s10534-015-9854-8.Full Text
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Helsel, Marian E., and Katherine J. Franz. “Pharmacological activity of metal binding agents that alter copper bioavailability.” Dalton Transactions (Cambridge, England : 2003) 44, no. 19 (May 2015): 8760–70. https://doi.org/10.1039/c5dt00634a.Full Text
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Bureš, Jan, Hana Jansová, Ján Stariat, Tomáš Filipský, Přemysl Mladěnka, Tomáš Šimůnek, Radim Kučera, et al. “LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).” Journal of Pharmaceutical and Biomedical Analysis 105 (February 2015): 55–63. https://doi.org/10.1016/j.jpba.2014.11.044.Full Text
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Safi, Rachid, Erik R. Nelson, Satish K. Chitneni, Katherine J. Franz, Daniel J. George, Michael R. Zalutsky, and Donald P. McDonnell. “Copper signaling axis as a target for prostate cancer therapeutics.” Cancer Res 74, no. 20 (October 15, 2014): 5819–31. https://doi.org/10.1158/0008-5472.CAN-13-3527.Full Text Open Access Copy Link to Item
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Franks, Andrew T., and Katherine J. Franz. “A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.” Chemical Communications (Cambridge, England) 50, no. 77 (October 2014): 11317–20. https://doi.org/10.1039/c4cc05076b.Full Text
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Jansová, Hana, Miloslav Macháček, Qin Wang, Pavlína Hašková, Anna Jirkovská, Eliška Potůčková, Filip Kielar, Katherine J. Franz, and Tomáš Simůnek. “Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.” Free Radical Biology & Medicine 74 (September 2014): 210–21. https://doi.org/10.1016/j.freeradbiomed.2014.06.019.Full Text
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Festa, Richard A., Marian E. Helsel, Katherine J. Franz, and Dennis J. Thiele. “Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.” Chemistry & Biology 21, no. 8 (August 2014): 977–87. https://doi.org/10.1016/j.chembiol.2014.06.009.Full Text
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Festa, R. A., M. E. Helsel, K. J. Franz, and D. J. Thiele. “Innate immune cell activation of a copper-dependent anti-cryptococcal agent.” Mycoses 57 (May 1, 2014): 56–57.Link to Item
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Franks, Andrew T., Degao Peng, Weitao Yang, and Katherine J. Franz. “Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties.” Inorganic Chemistry 53, no. 3 (February 2014): 1397–1405. https://doi.org/10.1021/ic402221x.Full Text
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Grant, Gerald A., Todd Hankinson, Carrie Muh, and Aaron Dumont. “The 62nd Annual Meeting of the Congress of Neurological Surgeons was held in Chicago, Illinois from October 6-10, 2012. Preface.” Neurosurgery 60 Suppl 1 (August 2013): v. https://doi.org/10.1227/NEU.0000000000000006.Full Text Link to Item
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Franz, Katherine J. “Clawing back: broadening the notion of metal chelators in medicine.” Current Opinion in Chemical Biology 17, no. 2 (April 2013): 143–49. https://doi.org/10.1016/j.cbpa.2012.12.021.Full Text
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Kumbhar, Anupa A., Andrew T. Franks, Raymond J. Butcher, and Katherine J. Franz. “Light uncages a copper complex to induce nonapoptotic cell death.” Chemical Communications (Cambridge, England) 49, no. 24 (March 2013): 2460–62. https://doi.org/10.1039/c3cc38927h.Full Text
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Folk, D. S., F. Kielar, and K. J. Franz. “Bioinorganic Neurochemistry” 3 (January 1, 2013): 207–40. https://doi.org/10.1016/B978-0-08-097774-4.00315-6.Full Text
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Kielar, Filip, Qin Wang, Paul D. Boyle, and Katherine J. Franz. “A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding.” Inorganica Chimica Acta 393 (December 2012): 294–303. https://doi.org/10.1016/j.ica.2012.06.011.Full Text
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Folk, Drew S., Justin C. Torosian, Sunhee Hwang, Dewey G. McCafferty, and Katherine J. Franz. “Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.” Angewandte Chemie (International Ed. in English) 51, no. 43 (October 2012): 10795–99. https://doi.org/10.1002/anie.201206673.Full Text
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Hyman, Lynne M., and Katherine J. Franz. “Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.” Coordination Chemistry Reviews 256, no. 19–20 (October 2012): 2333–56. https://doi.org/10.1016/j.ccr.2012.03.009.Full Text
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Kielar, Filip, Marian E. Helsel, Qin Wang, and Katherine J. Franz. “Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation.” Metallomics : Integrated Biometal Science 4, no. 9 (August 2012): 899–909. https://doi.org/10.1039/c2mt20069d.Full Text
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Franz, Katherine J. “Application of inorganic chemistry for non-cancer therapeutics.” Dalton Transactions (Cambridge, England : 2003) 41, no. 21 (June 2012): 6333–34. https://doi.org/10.1039/c2dt90061k.Full Text
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Rubino, Jeffrey T., and Katherine J. Franz. “Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function.” Journal of Inorganic Biochemistry 107, no. 1 (February 2012): 129–43. https://doi.org/10.1016/j.jinorgbio.2011.11.024.Full Text
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Hyman, Lynne M., and Katherine J. Franz. “A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence.” Inorganica Chimica Acta 380 (January 2012): 125–34. https://doi.org/10.1016/j.ica.2011.11.056.Full Text
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Leed, Marina G. D., Natalie Wolkow, David M. Pham, Catherine L. Daniel, Joshua L. Dunaief, and Katherine J. Franz. “Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.” Journal of Inorganic Biochemistry 105, no. 9 (September 2011): 1161–72. https://doi.org/10.1016/j.jinorgbio.2011.05.023.Full Text
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Haas, Kathryn L., Allison B. Putterman, Daniel R. White, Dennis J. Thiele, and Katherine J. Franz. “Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.” Journal of the American Chemical Society 133, no. 12 (March 2011): 4427–37. https://doi.org/10.1021/ja108890c.Full Text
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Ciesienski, Katie L., and Katherine J. Franz. “Keys for unlocking photolabile metal-containing cages.” Angewandte Chemie (International Ed. in English) 50, no. 4 (January 2011): 814–24. https://doi.org/10.1002/anie.201002542.Full Text
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Rubino, Jeffrey T., Michael P. Chenkin, Matthew Keller, Pamela Riggs-Gelasco, and Katherine J. Franz. “A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.” Metallomics : Integrated Biometal Science 3, no. 1 (January 2011): 61–73.
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Rubino, Jeffrey T., Michael P. Chenkin, Matthew Keller, Pamela Riggs-Gelasco, and Katherine J. Franz. “A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.” Metallomics : Integrated Biometal Science 3, no. 1 (January 2011): 61–73. https://doi.org/10.1039/c0mt00044b.Full Text
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Ciesienski, Katie L., Kathryn L. Haas, and Katherine J. Franz. “Development of next-generation photolabile copper cages with improved copper binding properties.” Dalton Transactions (Cambridge, England : 2003) 39, no. 40 (October 2010): 9538–46. https://doi.org/10.1039/c0dt00770f.Full Text Open Access Copy
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Rubino, Jeffrey T., Pamela Riggs-Gelasco, and Katherine J. Franz. “Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).” Journal of Biological Inorganic Chemistry : Jbic : A Publication of the Society of Biological Inorganic Chemistry 15, no. 7 (September 2010): 1033–49. https://doi.org/10.1007/s00775-010-0663-9.Full Text
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Ciesienski, Katie L., Lynne M. Hyman, Samir Derisavifard, and Katherine J. Franz. “Toward the detection of cellular copper(II) by a light-activated fluorescence increase.” Inorganic Chemistry 49, no. 15 (August 2010): 6808–10. https://doi.org/10.1021/ic1004165.Full Text Open Access Copy
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Folk, Drew S., and Katherine J. Franz. “A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.” Journal of the American Chemical Society 132, no. 14 (April 2010): 4994–95. https://doi.org/10.1021/ja100943r.Full Text Open Access Copy
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Franz, Katherine J., and Chuan He. “The highways and byways of bioinorganic chemistry.” Current Opinion in Chemical Biology 14, no. 2 (April 2010): 208–10. https://doi.org/10.1016/j.cbpa.2010.02.011.Full Text
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Perez, Lissette R., and Katherine J. Franz. “Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.” Dalton Transactions (Cambridge, England : 2003) 39, no. 9 (March 2010): 2177–87. https://doi.org/10.1039/b919237a.Full Text Open Access Copy
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Tangen, Espen, Jeanet Conradie, Katherine Franz, Simone Friedle, Joshua Telser, Stephen J. Lippard, and Abhik Ghosh. “Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand.” Inorganic Chemistry 49, no. 6 (March 2010): 2701–5. https://doi.org/10.1021/ic901860x.Full Text
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Crider, Sarah E., Robert J. Holbrook, and Katherine J. Franz. “Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.” Metallomics : Integrated Biometal Science 2, no. 1 (January 2010): 74–83. https://doi.org/10.1039/b916899k.Full Text Open Access Copy
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Dickens, Marina G., and Katherine J. Franz. “A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.” Chembiochem : A European Journal of Chemical Biology 11, no. 1 (January 2010): 59–62. https://doi.org/10.1002/cbic.200900597.Full Text
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Hyman, Lynne M., Clifton J. Stephenson, Marina G. Dickens, Ken D. Shimizu, and Katherine J. Franz. “Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.” Dalton Transactions (Cambridge, England : 2003), no. 2 (January 2010): 568–76. https://doi.org/10.1039/b914568k.Full Text
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Ciesienski, K. L., L. M. Hyman, D. T. Yang, K. L. Haas, M. G. Dickens, R. J. Holbrook, and K. J. Franz. “A photo-caged platinum(II) complex that increases cytotoxicity upon light activation.” European Journal of Inorganic Chemistry, no. 15 (January 1, 2010): 2224–28. https://doi.org/10.1002/ejic.201000098.Full Text
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Haas, Kathryn L., and Katherine J. Franz. “Application of metal coordination chemistry to explore and manipulate cell biology.” Chemical Reviews 109, no. 10 (October 2009): 4921–60. https://doi.org/10.1021/cr900134a.Full Text
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Palmer, Amy E., and Katherine J. Franz. “Introduction to "cellular metal homeostasis and trafficking".” Chemical Reviews 109, no. 10 (October 2009): 4533–35. https://doi.org/10.1021/cr900293t.Full Text
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Charkoudian, Louise K., Tzvete Dentchev, Nina Lukinova, Natalie Wolkow, Joshua L. Dunaief, and Katherine J. Franz. “Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.” Journal of Inorganic Biochemistry 102, no. 12 (December 2008): 2130–35. https://doi.org/10.1016/j.jinorgbio.2008.08.001.Full Text
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Ciesienski, Katie L., Kathryn L. Haas, Marina G. Dickens, Yohannes T. Tesema, and Katherine J. Franz. “A photolabile ligand for light-activated release of caged copper.” Journal of the American Chemical Society 130, no. 37 (September 2008): 12246–47. https://doi.org/10.1021/ja8047442.Full Text
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Franz, Katherine J. “Copper shares a piece of the pi.” Nature Chemical Biology 4, no. 2 (February 2008): 85–86. https://doi.org/10.1038/nchembio0208-85.Full Text
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Tesema, Yohannes T., David M. Pham, and Katherine J. Franz. “Counterions influence reactivity of metal ions with cysteinyldopa model compounds.” Inorganic Chemistry 47, no. 3 (February 2008): 1087–95. https://doi.org/10.1021/ic701889w.Full Text
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Charkoudian, Louise K., David M. Pham, Ashley M. Kwon, Abbey D. Vangeloff, and Katherine J. Franz. “Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.” Dalton Transactions (Cambridge, England : 2003), no. 43 (November 2007): 5031–42. https://doi.org/10.1039/b705199a.Full Text
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Liu, Lucy L., and Katherine J. Franz. “Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.” Journal of Biological Inorganic Chemistry : Jbic : A Publication of the Society of Biological Inorganic Chemistry 12, no. 2 (February 2007): 234–47. https://doi.org/10.1007/s00775-006-0181-y.Full Text
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Charkoudian, Louise K., David M. Pham, and Katherine J. Franz. “A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.” Journal of the American Chemical Society 128, no. 38 (September 2006): 12424–25. https://doi.org/10.1021/ja064806w.Full Text
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Tesema, Yohannes T., David M. Pham, and Katherine J. Franz. “Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin.” Inorganic Chemistry 45, no. 16 (August 2006): 6102–4. https://doi.org/10.1021/ic060262n.Full Text
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Charkoudian, Louise K., and Katherine J. Franz. “Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid.” Inorganic Chemistry 45, no. 9 (May 2006): 3657–64. https://doi.org/10.1021/ic060014r.Full Text
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Jiang, Jianfeng, Istvan A. Nadas, M Alison Kim, and Katherine J. Franz. “A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.” Inorganic Chemistry 44, no. 26 (December 2005): 9787–94. https://doi.org/10.1021/ic051180m.Full Text
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Liu, Lucy L., and Katherine J. Franz. “Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.” Journal of the American Chemical Society 127, no. 27 (July 2005): 9662–63. https://doi.org/10.1021/ja043247v.Full Text
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Nitz, Mark, Manashi Sherawat, Katherine J. Franz, Ezra Peisach, Karen N. Allen, and Barbara Imperiali. “Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide.” Angewandte Chemie (International Ed. in English) 43, no. 28 (July 2004): 3682–85. https://doi.org/10.1002/anie.200460028.Full Text
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Wöhnert, Jens, Katherine J. Franz, Mark Nitz, Barbara Imperiali, and Harald Schwalbe. “Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings.” Journal of the American Chemical Society 125, no. 44 (November 2003): 13338–39. https://doi.org/10.1021/ja036022d.Full Text
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Franz, Katherine J., Mark Nitz, and Barbara Imperiali. “Lanthanide-binding tags as versatile protein coexpression probes.” Chembiochem : A European Journal of Chemical Biology 4, no. 4 (April 2003): 265–71. https://doi.org/10.1002/cbic.200390046.Full Text
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Nitz, Mark, Katherine J. Franz, Rebecca L. Maglathlin, and Barbara Imperiali. “A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides.” Chembiochem : A European Journal of Chemical Biology 4, no. 4 (April 2003): 272–76. https://doi.org/10.1002/cbic.200390047.Full Text
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Franz, K. J., L. H. Doerrer, B. Spingler, and S. J. Lippard. “Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds.” Inorganic Chemistry 40, no. 15 (July 2001): 3774–80. https://doi.org/10.1021/ic010181l.Full Text
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Franz, K. J., N. Singh, B. Spingler, and S. J. Lippard. “Aminotroponiminates as ligands for potential metal-based nitric oxide sensors.” Inorganic Chemistry 39, no. 18 (September 2000): 4081–92. https://doi.org/10.1021/ic000344q.Full Text
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Franz, K. J., and S. J. Lippard. “Nitrosyl transfer from manganese to iron in tropocoronand complexes.” Inorganic Chemistry 39, no. 16 (August 2000): 3722–23. https://doi.org/10.1021/ic000360n.Full Text
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Franz, K. J., N. Singh, and S. J. Lippard. “Metal-based NO sensing by selective ligand dissociation.” Angewandte Chemie International Edition 39, no. 12 (2000): 2120–22. https://doi.org/10.1002/1521-3773(20000616)39:12<2120::AID-ANIE2120>3.0.CO;2-M.Full Text
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Franz, K. J., and S. J. Lippard. “NO disproportionation reactivity of Fe tropocoronand complexes.” Journal of the American Chemical Society 121, no. 45 (November 17, 1999): 10504–12. https://doi.org/10.1021/ja991664f.Full Text
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Franz, K. J., S. J. Lippard, D. Marlin, and P. Mascharak. “Disproportionation of nitric oxide promoted by a Mn tropocoronand.” Chemtracts 12, no. 2 (February 1, 1999): 135–40.
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Loehlin, J. H., K. J. Franz, L. Gist, and R. H. Moore. “Supramolecular Alcohol-Amine Crystals and Their Hydrogen-Bond Patterns.” Acta Crystallographica Section B: Structural Science 54, no. 5 (October 1, 1998): 695–704. https://doi.org/10.1107/S0108768198003231.Full Text
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Franz, K. J., and S. J. Lippard. “Disproportionation of nitric oxide promoted by a Mn tropocoronand.” Journal of the American Chemical Society 120, no. 35 (September 9, 1998): 9034–40. https://doi.org/10.1021/ja981410e.Full Text
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Huang, S. P., K. J. Franz, E. H. Arnold, J. Devenyi, and R. H. Fish. “Polymer pendant ligand chemistry-5. The selective and competitive removal of Ag+, Hg2+, Cu2+, Pb2+ and Cd2+ ions from aqueous solution utilizing a N-sulfonylethylenebis(dithiocarbamate) ligand anchored on macroporous polystyrene-divinylbenzene beads.” Polyhedron 15, no. 23 (September 6, 1996): 4241–54. https://doi.org/10.1016/0277-5387(96)00171-4.Full Text
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Huang, S. P., K. J. Franz, M. M. Olmstead, and R. H. Fish. “Synthetic and Structural Studies of a Linear Bis-Catechol Amide, N,N′-Bis(2,3-dihydroxybenzoyl)-1,7-diazaheptane (5-LICAM), and Its Complexes with Ni2+ and Co2+: Utilization of a Polymer-Supported, Sulfonated Analog, 5-LICAMS, as a Biomimetic Ligand for Divalent Metal Ion Removal from Aqueous Solution.” Inorganic Chemistry 34, no. 11 (May 1, 1995): 2820–25. https://doi.org/10.1021/ic00115a007.Full Text
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Huang, S. P., W. Li, K. J. Franz, R. L. Albright, and R. H. Fish. “Polymer Pendant Ligand Chemistry. 3. A Biomimetic Approach to Selective Metal Ion Removal and Recovery from Aqueous Solution with Polymer-Supported Sulfonated Catechol and Linear Catechol Amide Ligands.” Inorganic Chemistry 34, no. 11 (May 1, 1995): 2813–19. https://doi.org/10.1021/ic00115a006.Full Text
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Book Sections
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Wang, Q., and K. J. Franz. “Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes.” In Inorganic Chemical Biology: Principles, Techniques and Applications, 9781118510025:233–74, 2014. https://doi.org/10.1002/9781118682975.ch8.Full Text
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Conference Papers
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Franz, Katherine J. “Chemical Approaches for Manipulating Microbial Metals.” In Journal of Biological Inorganic Chemistry, 22:S215–S215. SPRINGER, 2017.Link to Item
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Franz, Katherine J. “Manipulating metals at the host-pathogen interface.” In Abstracts of Papers of the American Chemical Society, Vol. 247. AMER CHEMICAL SOC, 2014.Link to Item
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Franks, Andrew, Marian Helsel, and Katherine J. Franz. “Development of stimulus-responsive metal chelation with novel fluorescence reporting.” In Abstracts of Papers of the American Chemical Society, Vol. 245. AMER CHEMICAL SOC, 2013.Link to Item
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Folk, Drew S., Justin Torosian, and Katherine J. Franz. “BACE activated prochelator mediates A beta-Cu toxicity in an Alzheimer's disease cell model.” In Abstracts of Papers of the American Chemical Society, Vol. 243. AMER CHEMICAL SOC, 2012.Link to Item
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Franz, Katherine J. “Optimizing prochelators to bind metal ions in response to disease-associated stimuli[p].” In Abstracts of Papers of the American Chemical Society, Vol. 243. AMER CHEMICAL SOC, 2012.Link to Item
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Zielonka, Jacek, Filip Kielar, Adam Sikora, Katherine J. Franz, and Balaraman Kalyanaraman. “Dual Antioxidant Activity of Boronate-Based Prochelators: Scavenging Peroxynitrite and Metal Ion Chelation.” In Free Radical Biology and Medicine, 51:S100–101. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.480.Full Text
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Franz, Katherine J. “Design of prochelators that bind cellular metal ions in response to diverse stimuli.” In Abstracts of Papers of the American Chemical Society, Vol. 242. AMER CHEMICAL SOC, 2011.Link to Item
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Franz, Katherine J., and Kathryn L. Haas. “Insights into the role of histidine in Ctr1-dependent copper uptake.” In Abstracts of Papers of the American Chemical Society, Vol. 240. AMER CHEMICAL SOC, 2010.Link to Item
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Hyman, Lynne M., and Katherine J. Franz. “Development of triggereable chelating agents as probes for metal-induced oxidative stress.” In Abstracts of Papers of the American Chemical Society, Vol. 240. AMER CHEMICAL SOC, 2010.Link to Item
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Franz, Katherine J. “Recent developments in the design of triggerable chelating agents for altering metal coordination in biological settings.” In Abstracts of Papers of the American Chemical Society, Vol. 239. AMER CHEMICAL SOC, 2010.Link to Item
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Dickens, Marina G., Catherine L. Daniel, David M. Pham, and Katherine J. Franz. “Synthesis of masked bidentate and hexadentate iron chelators designed to reduce oxidative stress.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.Link to Item
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Franz, Katherine J. “Design of triggerable ligands for altering metal coordination in biological settings.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.Link to Item
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Haas, Kathryn L., Daniel R. White, and Katherine J. Franz. “Spectroscopic studies of N-terminal Cu(II)- and Cu(I)-binding hCtrl model peptides.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.Link to Item
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Rubino, Jeffrey T., and Katherine J. Franz. “Characterization of thioether-only Cu(I) binding by Ctr1 methionine motifs.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.Link to Item
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Ciesienski, Katie L., Kathryn L. Haas, Marina G. Dickens, and Katherine J. Franz. “Photolabile ligand for light-activated release of caged copper.” In Abstracts of Papers of the American Chemical Society, Vol. 237. AMER CHEMICAL SOC, 2009.Link to Item
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Crider, Sarah E., and Katherine J. Franz. “INOR 277-Interactions of cisplatin and methionine-rich peptide domains of the human high-affinity copper transporter Ctr1.” In Abstracts of Papers of the American Chemical Society, Vol. 235. AMER CHEMICAL SOC, 2008.Link to Item
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Hunt, Lynne M., and Kathenine J. Franz. “INOR 273-Development of prochelators as probes of iron-induced oxidative stress.” In Abstracts of Papers of the American Chemical Society, Vol. 235. AMER CHEMICAL SOC, 2008.Link to Item
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Franz, Katherine J., and Louise K. Charkoudian. “INOR 916-A pro-chelator strategy for inhibiting metal-catalyzed oxidative stress.” In Abstracts of Papers of the American Chemical Society, Vol. 234. AMER CHEMICAL SOC, 2007.Link to Item
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Charkoudian, Louise K., and Katherine J. Franz. “INOR 614-Development of iron chelators triggered by reactive oxygen species.” In Abstracts of Papers of the American Chemical Society, Vol. 232. AMER CHEMICAL SOC, 2006.Link to Item
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Franz, Katherine J., Kathryn Haas, Jeffrey Rubino, and David Pham. “INOR 1011-Copper(I) binding by methionine-rich domains of copper transport proteins.” In Abstracts of Papers of the American Chemical Society, Vol. 232. AMER CHEMICAL SOC, 2006.Link to Item
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Liu, L. L., and K. J. Franz. “Characterization of metal binding sites in a synthetic phosphorylated alpha-synuclein peptide fragment.” In Abstracts of Papers of the American Chemical Society, 229:U1080–81. AMER CHEMICAL SOC, 2005.Link to Item
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Franz, Katherine J., Mark Nitz, Elvedin Lukovic, and Barbara Imperiali. “Development of lanthanide-binding peptides as natively expressed protein probes.” In Journal of Inorganic Biochemistry, 96:131–131. Elsevier BV, 2003. https://doi.org/10.1016/s0162-0134(03)80614-1.Full Text
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- Teaching & Mentoring
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Recent Courses
- CHEM 393: Research Independent Study 2023
- CHEM 394: Research Independent Study 2023
- CHEM 493: Research Independent Study 2023
- CHEM 494: Research Independent Study 2023
- CHEM 393: Research Independent Study 2022
- CHEM 394: Research Independent Study 2022
- CHEM 493: Research Independent Study 2022
- CHEM 494: Research Independent Study 2022
- CHEM 393: Research Independent Study 2021
- CHEM 394: Research Independent Study 2021
- CHEM 493: Research Independent Study 2021
- CHEM 494: Research Independent Study 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- ICBIC 16, Keynote address; International Conference on Bioinorganic Chemistry. July 1, 2013 2013
- CanBIC, 4th Georgian Bay International Conference on Bioinorganic Chemistry. May 1, 2013 2013
- Plenary talk in the bio-inorganic chemistry and inorganic biochemistry"" symposium ". 96th Canadian Chemistry Conference. May 1, 2013 2013
- Pratt School of Engineering BioE Seminar Series. November 2011 2011
- Unknown. September 2011 2011
- International Conference on Bioinorganic Chemistry. August 2011 2011
- Metals in Cell Biology Gordon Conference. August 2011 2011
- University of North Carolina Wilmington. April 1, 2011 2011
- 14th International Conference on Biological Inorganic Chemistry (ICBIC 14). January 8, 2009 2009
- ACS National Meeting: invited speaker for special symposium “New Faces of Biomimetic Coordination Chemistry. January 8, 2009 2009
- Boston University. January 8, 2009 2009
- First International Conference in Metal-Chelation in Biology and Medicine. January 8, 2009 2009
- Lycoming College: The Willam and Barbara Haller Endowed Lectureship in Biology and Chemistry. January 8, 2009 2009
- NC State University. January 8, 2009 2009
- Stanford University. January 8, 2009 2009
- UC Berkeley. January 8, 2009 2009
- UC Irvine. January 8, 2009 2009
- Synta Pharmaceuticals. October 10, 2008 2008
- University of Massachusetts. October 9, 2008 2008
- Smith College. October 8, 2008 2008
- University of North Carolina. September 30, 2008 2008
- Old Dominion University. September 19, 2008 2008
- Northwestern University. April 18, 2008 2008
- Western Carolina University. April 4, 2008 2008
- University of North Carolina. March 17, 2008 2008
- Johns Hopkins University. February 19, 2008 2008
- Metals in Biology Gordon Conference. January 1, 2008 2008
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Service to the Profession
- Associate Editor. Metallomics. 2020 2020
- Editorial Advisory Board : Inorganic Chemistry. January 15, 2014 2014
- ACS Inorganic Chemistry Exam Committee. 2013 - 2014 2013 - 2014
- Co-vice chair elect : Metals in Medicine Gordon Research Conference. 2013 2013
- Organizing committee : 9th International BioMetals Symposium. 2013 2013
- Editorial Advisory Board : Metallomics. 2012 2012
- Elected : SBIC Council Member (Society of Biological Inorganic Chemistry). 2012 2012
- Appeared in ACS Publications “Why I…” publicity campaign. Photo ad appeared in C&EN News and Science, video clip ran at the ACS National Meeting in D. December 21, 2011 2011
- Guest Editor for special Themed Issue of Dalton Transactions entitled 'Application of Inorganic Chemistry for non-Cancer Therapeutics'. December 21, 2011 2011
- Panelist for “ACS On Campus” event at UNC Chapel Hill, Feb 2011. Session on "Women in Academia: Finding that Work/Life Balance.". December 21, 2011 2011
- Peer Reviewer for: JACS, Inorganic Chemistry, Dalton Transactions, Chemical Communications, Angewandte Chemie, Chemical Science, Journal of Inorganic. December 21, 2011 2011
- Peer Reviewer for: Research Corporation, National Cancer Institute, Alzheimer’s Foundation, National Science Foundation. December 21, 2011 2011
- Ad Hoc Reviewer for National Science Foundation, ACS Petroleum Research Fund, and the National Institutes of Health. January 8, 2009 2009
- Reviewer : Journal of the American Chemical Society, Inorganic Chemistry, Chemical Communications, Angewandte Chemie, Nature Protocols, Journal of Proteome Resea. January 8, 2009 2009
- Guest Co-Editor : Chemical Reviews, thematic issue on “Cellular Metal Trafficking and Regulation. 2009 2009
- Guest Co-Editor : Current Opinion in Chemical Biology, Bioinorganic Section. 2009 2009
- Peer review panelist : NSF Review Panel. January 7, 2008 2008
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