Scholars@Duke
Katherine J. Franz

Katherine J. Franz

James B. Duke Distinguished Professor of Chemistry
Chemistry
90346, Dept of Chemistry, 124 Science Dr., Durham, NC 27708-0346
2103 French Science Center, 124 Science Drive, Durham, NC 27708

Featured Works

Fluconazole analogues with metal-binding motifs impact metal-dependent processes and demonstrate antifungal activity in Candida albicans.

Journal article Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · August 2020 Featured Publication Azole antifungals are an important class of antifungal drugs due to their low cost, ability to be administered orally, and broad-spectrum activity. However, their widespread and long-term use have given rise to adaptation mechanisms that render these compo ... Full text Cite

A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-lactamase 1 without Removing Zinc.

Journal article ACS infectious diseases · May 2020 Featured Publication Antibacterial drug resistance is a rapidly growing clinical threat, partially due to expression of β-lactamase enzymes, which confer resistance to bacteria by hydrolyzing and inactivating β-lactam antibiotics. The increasing prevalence of metallo-β-lactama ... Full text Cite

A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis.

Journal article Nature chemical biology · March 2020 Featured Publication Infection by the fungal pathogen Cryptococcus neoformans causes lethal meningitis, primarily in immune-compromised individuals. Colonization of the brain by C. neoformans is dependent on copper (Cu) acquisition from the host, which drives critical virulenc ... Full text Cite