Scholars@Duke
Kathleen Ann Cooney

Kathleen Ann Cooney

George Barth Geller Distinguished Professor of Medicine
Medicine, Medical Oncology
kathleen.cooney@duke.edu
DUMC 3703, Duke North Hospital Suite 1102, Durham, NC 27710
40 Duke Medicine Circle, Davison Bldg, Suite 401, 401A, Durham, NC 27710

Scholarly Works - Conferences

Association between the rs72725854(A>T) allele and prostate cancer in males of African ancestry in a US population-based database.

Conference Journal of Clinical Oncology · June 1, 2026 10504Background: Black males have a 70% excess incidence of and two-fold higher morta ... Full text Cite

Abstract 3517: A germline variant at 8q24 contributes to familial clustering of prostate cancer in men of African ancestry

Conference Cancer Research · August 15, 2020 AbstractGermline variation at 8q24 is the strongest risk factor for prostate cancer (PCa) across all racial and ethnic populations. While most 8q24 associations have been observed across populations, rs72725 ... Full text Cite

Prevalence of pathogenic germline variants in DNA repair by race, age, and ethnicity in men with prostate cancer.

Conference Journal of Clinical Oncology · May 20, 2019 5062 Background: Patients with advanced prostate cancer (PC) frequently harbor pathogenic or likely pathogenic (P/LP) germline variants (GVs) in mismatch repair (MMR) and homologous repair (HR) enzymes which have clinical and tre ... Full text Cite

Abstract B40: Rare variant discovery in known cancer genes from whole-exome sequencingof African American hereditary prostate cancer families

Conference Cancer Epidemiology, Biomarkers & Prevention · March 1, 2016 AbstractAfrican American Hereditary Prostate Cancer Study (AAHPC) was developed as a national collaboration to explore the role of genetics in the causation of hereditary prostate cancer (HPC) in African Ame ... Full text Cite

Abstract 1585: Application of a graphene oxide based microfluidic device (GO Chip) to prostate cancer circulating tumor cell capture and analysis

Conference Cancer Research · August 1, 2015 AbstractOne in seven men in the United States will be diagnosed with prostate cancer in his life time, in part because of the prevalence of screening for serum levels of prostate specific antigen (PSA). Howe ... Full text Cite

Abstract 2564: Identification of a novel SPOP missense mutation from targeted next-generation sequencing of men with chromosome 17-q linkage.

Conference Cancer Research · April 15, 2013 AbstractSpeckle-type POZ protein (SPOP), located on chromosome 17q21, encodes the substrate-binding subunit of a Cullin-based E3 ubiquitin ligase gene. The SPOP gene has been shown to be one of the most comm ... Full text Cite

Abstract 1642: Rare missense variants in MAP3K14 and ARHGAP27 in men with hereditary prostate cancer

Conference Cancer Research · April 15, 2012 AbstractBackground: Linkage studies have consistently identified the 17q21-22 chromosomal region to be important in hereditary prostate cancer, although no known causal variant has yet been identified. Three ... Full text Cite

National Cancer Institute Prostate Cancer Genetics Workshop.

Conference Cancer Res · May 15, 2011 Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It re ... Full text Link to item Cite

Abstract 5569: The association between statin use and risk of biochemical recurrence in men treated with radical prostatectomy in a cohort of men with inherited forms of prostate cancer

Conference Cancer Research · April 15, 2011 AbstractBackground: Evidence exists that statin medications are associated with decreased risk of advanced prostate cancer. The risk factors for prostate cancer are increasing age, African-American race and ... Full text Cite

Family history of prostate cancer and relapse after definitive external beam radiation therapy.

Conference Int J Radiat Oncol Biol Phys · October 1, 2003 PURPOSE: The influence of family history on outcome after definitive therapy for prostate cancer has been disputed. One series reported increased relapse rates in men with a positive family history of prostate cancer treated with radical prostatectomy or r ... Full text Link to item Cite

Evaluating the utility of available differential diagnosis systems

Conference Proceedings Annual Symposium on Computer Applications in Medical Care · November 1, 1988 Results of an evaluation testing the accuracy and performance of two differential diagnosis systems, Meditel and DXplain, obtained by utilizing 103 consecutive clinical cases culled from the Internal Medicine Service at the University of Michigan, are pres ... Cite