Scholars@Duke
Kathryn Hornburg

Kathryn Hornburg

Data Administration Analyst
Radiology
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Selected Publications

Merged magnetic resonance and light sheet microscopy of the whole mouse brain.

Journal Article Proc Natl Acad Sci U S A · April 25, 2023 We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We start with MRH of the brain in the skull with gradient echo and diffusion tensor im ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal Article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year.

Journal Article NMR Biomed · January 2022 While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over extended periods. This mouse ... Full text Link to item Cite

Vector-apodizing phase plate coronagraph: design, current performance, and future development [Invited].

Journal Article Applied optics · July 2021 Over the last decade, the vector-apodizing phase plate (vAPP) coronagraph has been developed from concept to on-sky application in many high-contrast imaging systems on 8 m class telescopes. The vAPP is a geometric-phase patterned coronagraph that is inher ... Full text Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal Article Radiol Imaging Cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Link to item Cite

Producing true-color rainbows with patterned multi-layer liquid-crystal polarization gratings

Journal Article Optical Materials Express · April 1, 2019 We present the technical design of the art installation Rainbow Station, that projects a 40-m diameter true-color rainbow. The core technology is comprised of a patterned polarization grating that produces the rainbow with the correct shape and correct col ... Full text Cite

Highly chromatic retardation via multi-twist liquid crystal films

Journal Article Journal of the Optical Society of America B: Optical Physics · January 1, 2019 Here we study birefringent films with highly customizable chromatic retardation spectra, using multi-twist liquid crystal (LC) films. These are made of two or more layers of chiral nematic LC polymer network materials, also known as reactive mesogens, whic ... Full text Cite

Design and fabrication of an aspheric geometric-phase lens doublet

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2018 A prior simulation-only study of aspherical phase profiles [Hornburg et al, Proc SPIE 10743, 10743-4 (2018)] in geometric-phase lenses (GPLs) indicated that aspherical doublet lens systems should provide substantially improved off-axis performance than tho ... Full text Cite

Optimization of aspheric geometric-phase lenses for improved field-of-view

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2018 In optical thin-films and surfaces, geometric phase is utilized to control the phase beyond that possible through optical path differences. Geometric-phase lenses, which are significantly thinner than refractive lenses for the same numerical aperture (NA), ... Full text Cite

An experimental study of single-film wide gamut multi-twist retarders

Journal Article Molecular Crystals and Liquid Crystals · April 13, 2017 Multi-Twist Retarders (MTRs) are a class of complex retarders created by stacking multiple layers of various polymerizable nematic liquid crystal mixtures, where a chiral dopant may be added to each layer to control its twisting power. MTRs have a set of t ... Full text Cite

ON-SKY PERFORMANCE ANALYSIS of the VECTOR APODIZING PHASE PLATE CORONAGRAPH on MagAO/Clio2

Journal Article Astrophysical Journal · January 10, 2017 We report on the performance of a vector apodizing phase plate coronagraph that operates over a wavelength range of 2-5 μm and is installed in MagAO/Clio2 at the 6.5 m Magellan Clay telescope at Las Campanas Observatory, Chile. The coronagraph manipulates ... Full text Cite

Experimental characterization of a F/1.5 geometric-phase lens with high-achromatic efficiency and low aberration

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2017 We report on the properties of a fast F/1.5 geometric-phase lens with a focal length of 37 mm at 633 nm and a 24.5 mm diameter. This lens employs photo-aligned liquid crystal layers to implement the spatially varying Pancharatnam-Berry phase, leading to th ... Full text Cite

Wide-color gamut multi-twist retarders

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2015 We show how highly chromatic Multi-Twist Retarder (MTR) films can be used to create a single-film color filter wherein the color may be selected only by the MTR orientation angle. By this approach, we can create multi- color images with just an MTR between ... Full text Cite

Merged magnetic resonance and light sheet microscopy of the whole mouse brain.

Journal Article Proc Natl Acad Sci U S A · April 25, 2023 We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We start with MRH of the brain in the skull with gradient echo and diffusion tensor im ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal Article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year.

Journal Article NMR Biomed · January 2022 While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over extended periods. This mouse ... Full text Link to item Cite

Vector-apodizing phase plate coronagraph: design, current performance, and future development [Invited].

Journal Article Applied optics · July 2021 Over the last decade, the vector-apodizing phase plate (vAPP) coronagraph has been developed from concept to on-sky application in many high-contrast imaging systems on 8 m class telescopes. The vAPP is a geometric-phase patterned coronagraph that is inher ... Full text Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal Article Radiol Imaging Cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Link to item Cite

Producing true-color rainbows with patterned multi-layer liquid-crystal polarization gratings

Journal Article Optical Materials Express · April 1, 2019 We present the technical design of the art installation Rainbow Station, that projects a 40-m diameter true-color rainbow. The core technology is comprised of a patterned polarization grating that produces the rainbow with the correct shape and correct col ... Full text Cite

Highly chromatic retardation via multi-twist liquid crystal films

Journal Article Journal of the Optical Society of America B: Optical Physics · January 1, 2019 Here we study birefringent films with highly customizable chromatic retardation spectra, using multi-twist liquid crystal (LC) films. These are made of two or more layers of chiral nematic LC polymer network materials, also known as reactive mesogens, whic ... Full text Cite

Design and fabrication of an aspheric geometric-phase lens doublet

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2018 A prior simulation-only study of aspherical phase profiles [Hornburg et al, Proc SPIE 10743, 10743-4 (2018)] in geometric-phase lenses (GPLs) indicated that aspherical doublet lens systems should provide substantially improved off-axis performance than tho ... Full text Cite

Optimization of aspheric geometric-phase lenses for improved field-of-view

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2018 In optical thin-films and surfaces, geometric phase is utilized to control the phase beyond that possible through optical path differences. Geometric-phase lenses, which are significantly thinner than refractive lenses for the same numerical aperture (NA), ... Full text Cite

An experimental study of single-film wide gamut multi-twist retarders

Journal Article Molecular Crystals and Liquid Crystals · April 13, 2017 Multi-Twist Retarders (MTRs) are a class of complex retarders created by stacking multiple layers of various polymerizable nematic liquid crystal mixtures, where a chiral dopant may be added to each layer to control its twisting power. MTRs have a set of t ... Full text Cite

ON-SKY PERFORMANCE ANALYSIS of the VECTOR APODIZING PHASE PLATE CORONAGRAPH on MagAO/Clio2

Journal Article Astrophysical Journal · January 10, 2017 We report on the performance of a vector apodizing phase plate coronagraph that operates over a wavelength range of 2-5 μm and is installed in MagAO/Clio2 at the 6.5 m Magellan Clay telescope at Las Campanas Observatory, Chile. The coronagraph manipulates ... Full text Cite

Experimental characterization of a F/1.5 geometric-phase lens with high-achromatic efficiency and low aberration

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2017 We report on the properties of a fast F/1.5 geometric-phase lens with a focal length of 37 mm at 633 nm and a 24.5 mm diameter. This lens employs photo-aligned liquid crystal layers to implement the spatially varying Pancharatnam-Berry phase, leading to th ... Full text Cite

Wide-color gamut multi-twist retarders

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2015 We show how highly chromatic Multi-Twist Retarder (MTR) films can be used to create a single-film color filter wherein the color may be selected only by the MTR orientation angle. By this approach, we can create multi- color images with just an MTR between ... Full text Cite

Multiband retardation control using multi-twist retarders

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2014 We introduce and demonstrate an approach to create highly chromatic retardation spectra across various wave-lengths. The design approach is based on Multi-Twist Retarder (MTR) principle where multiple liquid crystal polymer layers are coated on top of each ... Full text Cite