Journal articleNat Neurosci · April 2026
Alzheimer's disease has widespread effects on brain structure, function and behavior, but we lack a systematic dissection of its impact across hundreds of forebrain and brainstem regions. Here, using diffusion tensor MRI at 25 µm, we mapped the global cons ...
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Journal articleSci Adv · May 2, 2025
Atlases of the brain are critical resources that make it possible to share data in a common reference frame. Unexpectedly, there is no three-dimensional (3D) stereotaxic atlas of the mouse brain that provides whole brain coverage at macro to single-cell le ...
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Journal articlePart Fibre Toxicol · May 1, 2025
BACKGROUND: Both excess brain Fe and air pollution (AP) exposures are associated with increased risk for multiple neurodegenerative disorders. Fe is a redox-active metal that is abundant in AP and even further elevated in U.S. subway systems. Exposures to ...
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Preprint · 2025
ABSTRACT Alzheimer’s disease (AD) affects brain regions with remarkable heterogeneity, but the precise impact of this disease on hundreds of small cortical, subcortical, and brainstem regions remains poorly defined. Here, as a prelude to testing ...
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Journal articleBehav Brain Funct · June 19, 2024
BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accompanied by repetitive behavior, and d ...
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Preprint · March 31, 2024
We have combined MR histology and light sheet microscopy (LSM) of five postmortem C57BL/6J mouse brains in a stereotaxic space based on micro-CT yielding a multimodal 3D atlas with the highest spatial and contrast resolution yet reported. Brains were image ...
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Journal articleProc Natl Acad Sci U S A · April 25, 2023
We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We start with MRH of the brain in the skull with gradient echo and diffusion tensor im ...
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Journal articleNMR Biomed · February 2023
The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ...
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Preprint · May 23, 2022
Here we study aspheric phase pattern geometric-phase lenses through the design of doublet lenses in Zemax Optic Studio and in MATLAB using a simple ray tracing code. The solutions developed use variable spacer distances and are solved monochromatically (at ...
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Journal articleNMR Biomed · January 2022
While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over extended periods. This mouse ...
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Preprint · 2022
ABSTRACT We have developed new imaging and computational workflows to produce accurately aligned multimodal 3D images of the mouse brain that exploit high resolution magnetic resonance histology (MRH) and light sheet microscopy (LSM) with fully r ...
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Journal articleApplied optics · July 2021
Over the last decade, the vector-apodizing phase plate (vAPP) coronagraph has been developed from concept to on-sky application in many high-contrast imaging systems on 8 m class telescopes. The vAPP is a geometric-phase patterned coronagraph that is inher ...
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Journal articleRadiol Imaging Cancer · May 2021
Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ...
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Preprint · 2021
Paul Lauterbur closed his seminal paper on MRI with the statement that “zeugmatographic (imaging) techniques should find many useful applications in studies of the internal structures, states and composition of microscopic objects” [1]. Magnetic resonance ...
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Preprint · 2020
ABSTRACT While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed ex-vivo tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over ex ...
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Journal articleOptical Materials Express · April 1, 2019
We present the technical design of the art installation Rainbow Station, that projects a 40-m diameter true-color rainbow. The core technology is comprised of a patterned polarization grating that produces the rainbow with the correct shape and correct col ...
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Journal articleJournal of the Optical Society of America B Optical Physics · January 1, 2019
Here we study birefringent films with highly customizable chromatic retardation spectra, using multi-twist liquid crystal (LC) films. These are made of two or more layers of chiral nematic LC polymer network materials, also known as reactive mesogens, whic ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2018
A prior simulation-only study of aspherical phase profiles [Hornburg et al, Proc SPIE 10743, 10743-4 (2018)] in geometric-phase lenses (GPLs) indicated that aspherical doublet lens systems should provide substantially improved off-axis performance than tho ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2018
In optical thin-films and surfaces, geometric phase is utilized to control the phase beyond that possible through optical path differences. Geometric-phase lenses, which are significantly thinner than refractive lenses for the same numerical aperture (NA), ...
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Journal articleMolecular Crystals and Liquid Crystals · April 13, 2017
Multi-Twist Retarders (MTRs) are a class of complex retarders created by stacking multiple layers of various polymerizable nematic liquid crystal mixtures, where a chiral dopant may be added to each layer to control its twisting power. MTRs have a set of t ...
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Journal articleAstrophysical Journal · January 10, 2017
We report on the performance of a vector apodizing phase plate coronagraph that operates over a wavelength range of 2-5 μm and is installed in MagAO/Clio2 at the 6.5 m Magellan Clay telescope at Las Campanas Observatory, Chile. The coronagraph manipulates ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2017
We report on the properties of a fast F/1.5 geometric-phase lens with a focal length of 37 mm at 633 nm and a 24.5 mm diameter. This lens employs photo-aligned liquid crystal layers to implement the spatially varying Pancharatnam-Berry phase, leading to th ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2015
We show how highly chromatic Multi-Twist Retarder (MTR) films can be used to create a single-film color filter wherein the color may be selected only by the MTR orientation angle. By this approach, we can create multi- color images with just an MTR between ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2014
We introduce and demonstrate an approach to create highly chromatic retardation spectra across various wave-lengths. The design approach is based on Multi-Twist Retarder (MTR) principle where multiple liquid crystal polymer layers are coated on top of each ...
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