Kathryn Hornburg

Journal article Nat Neurosci · April 2026 Alzheimer's disease has widespread effects on brain structure, function and behavior, but we lack a systematic dissection of its impact across hundreds of forebrain and brainstem regions. Here, using diffusion tensor MRI at 25 µm, we mapped the global cons ... Full text Link to item Cite

The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain.

Journal article Sci Adv · May 2, 2025 Atlases of the brain are critical resources that make it possible to share data in a common reference frame. Unexpectedly, there is no three-dimensional (3D) stereotaxic atlas of the mouse brain that provides whole brain coverage at macro to single-cell le ... Full text Link to item Cite

Brain iron accumulation in neurodegenerative disorders: Does air pollution play a role?

Journal article Part Fibre Toxicol · May 1, 2025 BACKGROUND: Both excess brain Fe and air pollution (AP) exposures are associated with increased risk for multiple neurodegenerative disorders. Fe is a redox-active metal that is abundant in AP and even further elevated in U.S. subway systems. Exposures to ... Full text Link to item Cite

Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability.

Journal article Behav Brain Funct · June 19, 2024 BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accompanied by repetitive behavior, and d ... Full text Link to item Cite

Merged magnetic resonance and light sheet microscopy of the whole mouse brain.

Journal article Proc Natl Acad Sci U S A · April 25, 2023 We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We start with MRH of the brain in the skull with gradient echo and diffusion tensor im ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year.

Journal article NMR Biomed · January 2022 While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over extended periods. This mouse ... Full text Link to item Cite

Vector-apodizing phase plate coronagraph: design, current performance, and future development [Invited].

Journal article Applied optics · July 2021 Over the last decade, the vector-apodizing phase plate (vAPP) coronagraph has been developed from concept to on-sky application in many high-contrast imaging systems on 8 m class telescopes. The vAPP is a geometric-phase patterned coronagraph that is inher ... Full text Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal article Radiol Imaging Cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Link to item Cite

Producing true-color rainbows with patterned multi-layer liquid-crystal polarization gratings

Journal article Optical Materials Express · April 1, 2019 We present the technical design of the art installation Rainbow Station, that projects a 40-m diameter true-color rainbow. The core technology is comprised of a patterned polarization grating that produces the rainbow with the correct shape and correct col ... Full text Cite

Highly chromatic retardation via multi-twist liquid crystal films

Journal article Journal of the Optical Society of America B Optical Physics · January 1, 2019 Here we study birefringent films with highly customizable chromatic retardation spectra, using multi-twist liquid crystal (LC) films. These are made of two or more layers of chiral nematic LC polymer network materials, also known as reactive mesogens, whic ... Full text Cite

An experimental study of single-film wide gamut multi-twist retarders

Journal article Molecular Crystals and Liquid Crystals · April 13, 2017 Multi-Twist Retarders (MTRs) are a class of complex retarders created by stacking multiple layers of various polymerizable nematic liquid crystal mixtures, where a chiral dopant may be added to each layer to control its twisting power. MTRs have a set of t ... Full text Cite

ON-SKY PERFORMANCE ANALYSIS of the VECTOR APODIZING PHASE PLATE CORONAGRAPH on MagAO/Clio2

Journal article Astrophysical Journal · January 10, 2017 We report on the performance of a vector apodizing phase plate coronagraph that operates over a wavelength range of 2-5 μm and is installed in MagAO/Clio2 at the 6.5 m Magellan Clay telescope at Las Campanas Observatory, Chile. The coronagraph manipulates ... Full text Cite