Scholarly Works - Preprints
Preprint
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2025
ABSTRACT Alzheimer’s disease (AD) affects brain regions with remarkable heterogeneity, but the precise impact of this disease on hundreds of small cortical, subcortical, and brainstem regions remains poorly defined. Here, as a prelude to testing ...
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Preprint
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March 31, 2024
We have combined MR histology and light sheet microscopy (LSM) of five postmortem C57BL/6J mouse brains in a stereotaxic space based on micro-CT yielding a multimodal 3D atlas with the highest spatial and contrast resolution yet reported. Brains were image ...
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Preprint
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May 23, 2022
Here we study aspheric phase pattern geometric-phase lenses through the design of doublet lenses in Zemax Optic Studio and in MATLAB using a simple ray tracing code. The solutions developed use variable spacer distances and are solved monochromatically (at ...
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Preprint
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2022
ABSTRACT We have developed new imaging and computational workflows to produce accurately aligned multimodal 3D images of the mouse brain that exploit high resolution magnetic resonance histology (MRH) and light sheet microscopy (LSM) with fully r ...
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Preprint
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2021
Paul Lauterbur closed his seminal paper on MRI with the statement that “zeugmatographic (imaging) techniques should find many useful applications in studies of the internal structures, states and composition of microscopic objects” [1]. Magnetic resonance ...
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Preprint
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2020
ABSTRACT While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed ex-vivo tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over ex ...
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