Kelly Hogan

Conference Annals of the New York Academy of Sciences · January 2001 In this paper we report on studies of platelet adhesion to several fibrinogen gamma chain variants under physiological flow conditions. Reduced platelet adhesion was found to patient dysfibrinogen Vlissingen and its recombinant form (deletion of gamma 319- ... Full text Cite

The formation of beta fibrin requires a functional a site.

Conference Annals of the New York Academy of Sciences · January 2001 We used recombinant fibrinogens in which the a site is disrupted to examine beta-fibrin formation in the absence of a functional a site. Our variants have only b sites available, and they showed no evidence of fibrin polymer formation after cleavage of FpB ... Full text Cite

Synthesis of a mouse model of the dysfibrinogen Vlissingen/Frankfurt IV.

Conference Annals of the New York Academy of Sciences · January 2001 The dysfibrinogen Vlissingen/Frankfurt IV is characterized as a deletion of Asn319 and Asp320 from the C-terminus of the gamma-chain of fibrinogen. This dysfibrinogen, which was identified in several family members that are all heterozygous for the in-fram ... Full text Cite

Polymerization site a function dependence on structural integrity of its nearby calcium binding site.

Conference Annals of the New York Academy of Sciences · January 2001 To explore the functional relationship between the polymerization site a and the nearby high affinity calcium binding site, we analyzed four variant fibrinogens with substitutions at these sites: gamma D364A in the a site and gamma D318A, gamma D320A, and ... Full text Cite