Scholars@Duke
Kevin Dennis Hill

Kevin Dennis Hill

Professor of Pediatrics
Pediatrics, Cardiology
kevin.hill@duke.edu
DUMC Box 3090, Durham, NC 27710
Room 7506 - Duke Hospital North, DUMC Box 3090, Durham, NC 27710

Scholarly Works - Journal articles

A scoping review of the evidence supporting antiarrhythmic use after paediatric cardiac surgery.

Journal article Cardiol Young · July 3, 2026 BACKGROUND: Arrhythmias after paediatric cardiac surgery occur frequently and contribute to postoperative morbidity and mortality. There is limited literature assessing the safety and efficacy of common antiarrhythmics administered in this population. METH ... Full text Link to item Cite

Rethinking Neonatal Surgical Urgency: Effective Delay with Internal Flow Restrictors.

Journal article Ann Thorac Surg · June 23, 2026 BACKGROUND: Neonates with complex congenital heart disease frequently develop pulmonary overcirculation, but early surgical intervention may be poorly tolerated due to physiologic instability, prematurity, or comorbidities. Percutaneous internal pulmonary ... Full text Link to item Cite

Single-Ventricle Disease: Long-Term Outcomes and Global Morbidity in the Single Ventricle Reconstruction Trial.

Journal article J Am Coll Cardiol · June 9, 2026 BACKGROUND: In the Single Ventricle Reconstruction (SVR) trial, 1-year transplant-free survival favored the right ventricle-to-pulmonary artery shunt (RVPAS) over the modified Blalock-Taussig-Thomas shunt. However, this benefit diminished over time, and lo ... Full text Link to item Cite

Reexploring the STRESS Trial: Subgroup Postoperative Outcomes Following Methylprednisolone for Infant Heart Surgery.

Journal article Pediatr Cardiol · March 2026 UNLABELLED: Objective Assess the association between intraoperative methylprednisolone and specific postoperative outcomes among subgroups undergoing infant heart surgery. DESIGN: Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after ... Full text Link to item Cite

Predicting pulmonary hypertension in infants with bronchopulmonary dysplasia.

Journal article J Perinatol · February 16, 2026 OBJECTIVE: Develop and validate predictive models for pulmonary hypertension (PH) in high-risk infants. STUDY DESIGN: We trained logistic regression (LR) and long short-term memory (LSTM) models using a multicenter cohort study of infants 22-28 weeks gesta ... Full text Link to item Cite

A Bayesian re-analysis of the STRESS trial.

Journal article Am Heart J · February 2026 BACKGROUND: Prophylactic steroids are often used to reduce the systemic inflammatory response to cardiopulmonary bypass in infants undergoing heart surgery. The STRESS trial found that the odds of a worse outcome did not differ between infants randomized t ... Full text Link to item Cite

Health-Related Quality of Life in Children with Hypoplastic Left Heart Syndrome: Changes over Time and Associations with Neurodevelopmental and Clinical Factors.

Journal article J Pediatr · February 2026 OBJECTIVES: To evaluate changes in health-related quality of life (HRQOL) over time as perceived by parents and to examine associations between neurodevelopmental and clinical factors and patient-reported HRQOL in a large multicenter cohort of children wit ... Full text Link to item Cite

Chronic Lung Disease-Related Pulmonary Hypertension in Children.

Journal article Acta Paediatr · January 2026 AIM: Pulmonary hypertension (PH) is characterised by elevated pressures in the pulmonary arterial system. Despite its high mortality, paediatric PH has few approved treatments. Our aim was to review the latest diagnostic and treatment considerations for pa ... Full text Link to item Cite

Routine Use of Ultrasound in the Identification and Management of Thrombosis Following Pediatric Cardiac Catheterization.

Journal article Catheter Cardiovasc Interv · December 2025 BACKGROUND: Vessel occlusion post-catheterization is a common complication, yet there is no standard for diagnosis and treatment. As a result, there is variability in identification and management of post-catheterization thrombosis. AIMS: We aimed to (1) d ... Full text Link to item Cite

Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial.

Journal article J Am Heart Assoc · August 19, 2025 BACKGROUND: In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo2) at peak exercise. This disparate ... Full text Link to item Cite

Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.

Journal article Crit Care Med · July 1, 2025 OBJECTIVES: Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery. DESIGN: Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) ... Full text Link to item Cite

Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation.

Journal article J Am Heart Assoc · April 2025 BACKGROUND: There is significant interest in NO pathway modulators, specifically type 5 phosphodiesterase inhibitors (PDE5is), to treat patients with a Fontan circulation. Trials, however, have had mixed results. The relationship between the NO pathway and ... Full text Link to item Cite

National practice patterns for the use of regional anesthesia for pediatric cardiac surgery: An analysis of the Society of Thoracic Surgeons congenital heart surgery database.

Journal article J Clin Anesth · March 2025 BACKGROUND: Complications associated with suboptimal pain management after pediatric cardiac surgery have increased interest in regional anesthesia (RA). We sought to evaluate national trends and explore the association of RA with postoperative outcomes fo ... Full text Link to item Cite

A Bayesian Re-analysis of the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Trial.

Journal article medRxiv · February 12, 2025 BACKGROUND: Prophylactic steroids are often used to reduce the systemic inflammatory response to cardiopulmonary bypass in infants undergoing heart surgery. The STRESS trial found that the likelihood of a worse outcome did not differ between infants random ... Full text Link to item Cite

" Trying to Grab Pieces of Hope " : Exploring the Experiences of Black and Hispanic Parents following a Congenital Heart Disease Diagnosis.

Journal article AJP Rep · January 2025 Objective  Congenital heart disease (CHD) is an important contributor to pediatric morbidity and mortality. Unfortunately, disparities in the diagnosis and treatment of CHD exist across racial and ethnic groups. The objective of this study was to share the ... Full text Open Access Link to item Cite

Mobile health monitoring of children with CHDs.

Journal article Cardiol Young · November 2024 BACKGROUND: Mobile health has been shown to improve quality, access, and efficiency of health care in select populations. We sought to evaluate the benefits of mobile health monitoring using the KidsHeart app in an infant CHD population. METHODS: We review ... Full text Link to item Cite

Additive value of invasive haemodynamic assessment for predicting post-operative outcomes after Fontan.

Journal article Cardiol Young · October 2024 Routine pre-Fontan cardiac catheterization remains standard practice at most centres. However, with advances in non-invasive risk assessment, an invasive haemodynamic assessment may not be necessary for all patients.Using retrospective data from patients u ... Full text Link to item Cite

Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.

Journal article Cardiovasc Eng Technol · August 2024 PURPOSR: This study created 3D CFD models of the Norwood procedure for hypoplastic left heart syndrome (HLHS) using standard angiography and echocardiogram data to investigate the impact of shunt characteristics on pulmonary artery (PA) hemodynamics. Lever ... Full text Link to item Cite

Evaluating registry-based trial economics: Results from the STRESS clinical trial.

Journal article Contemp Clin Trials Commun · April 2024 BACKGROUND: Registry-based trials have the potential to reduce randomized clinical trial (RCT) costs. However, observed cost differences also may be achieved through pragmatic trial designs. A systematic comparison of trial costs across different designs h ... Full text Link to item Cite

Population Pharmacokinetics of Caffeine in Neonates with Congenital Heart Disease and Associations with Acute Kidney Injury.

Journal article J Clin Pharmacol · March 2024 Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in approximately 65% of neonates undergoing cardiac surgery on cardiopulmonary bypass and contributes to morbidity and mortality. Caffeine may reduce CS-AKI by counteracting adenosine receptor ... Full text Open Access Link to item Cite

Preoperative Hemodynamics Impact the Benefit of Fenestration on Fontan Postoperative Length of Stay.

Journal article JACC Adv · March 2024 BACKGROUND: Utilization of Fontan fenestration varies considerably by center. OBJECTIVES: Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use of Font ... Full text Link to item Cite

Outcomes of the Kawashima: A Society of Thoracic Surgeons Congenital Heart Surgery Database Analysis.

Journal article Ann Thorac Surg · February 2024 BACKGROUND: We aimed to evaluate the effect of age at operation on postoperative outcomes in children undergoing a Kawashima operation. METHODS: The Society of Thoracic Surgeons Congenital Heart Surgery Database was queried for Kawashima procedures from Ja ... Full text Link to item Cite

The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis.

Journal article Pediatr Cardiol · December 2023 The Pediatric Heart Network's Fontan Udenafil Exercise Longitudinal (FUEL) Trial (Mezzion Pharma Co. Ltd., NCT02741115) demonstrated improvements in some measures of exercise capacity and in the myocardial performance index following 6 months of treatment ... Full text Link to item Cite

Improving Outcomes for Infants After Cardiopulmonary Bypass Surgery for Congenital Heart Disease: A Commentary on Recent Randomized Controlled Trials.

Journal article Pediatr Crit Care Med · November 1, 2023 The recent NITRIC and STRESS trials demonstrate opportunities to perform pragmatic large randomized trials in congenital heart disease. We discuss lessons learnt from these trials which can inform future trial design and conduct in the field of pediatric h ... Full text Link to item Cite

Center-level factors associated with shorter length of stay following stage 1 palliation: An analysis of the national pediatric cardiology quality improvement collaborative registry.

Journal article Am Heart J · November 2023 BACKGROUND: Stage 1 single ventricle palliation (S1P) has the longest length of stay (LOS) of all benchmark congenital heart operations. Center-level factors contributing to prolonged hospitalization are poorly defined. METHODS: We analyzed data from infan ... Full text Link to item Cite

Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study.

Journal article Circulation · October 24, 2023 OBJECTIVE: In the SVR trial (Single Ventricle Reconstruction), newborns with hypoplastic left heart syndrome were randomly assigned to receive a modified Blalock-Taussig-Thomas shunt (mBTTS) or a right ventricle-to-pulmonary artery shunt (RVPAS) at Norwood ... Full text Link to item Cite

Contemporary Patterns of Care in Tetralogy of Fallot: Analysis of The Society of Thoracic Surgeons Data.

Journal article Ann Thorac Surg · October 2023 BACKGROUND: Against the background of earlier studies, recent patterns in surgical management of tetralogy of Fallot (TOF) were assessed. METHODS: A retrospective review of The Society of Thoracic Surgeons (STS) Congenital Database (2010-2020) was performe ... Full text Link to item Cite

A point-of-care pharmacokinetic/pharmacodynamic trial in critically ill children: Study design and feasibility.

Journal article Contemp Clin Trials Commun · October 2023 BACKGROUND: High-quality, efficient, pharmacokinetic (PK), pharmacodynamic (PD), and safety studies in children are needed. Point-of-care trials in adults have facilitated clinical trial participation for patients and providers, minimized the disruption of ... Full text Link to item Cite

Development of a Novel Society of Thoracic Surgeons Adult Congenital Mortality Risk Model.

Journal article Ann Thorac Surg · August 2023 BACKGROUND: Operative mortality risk models for adults with congenital heart disease (ACHD) undergoing cardiac operations are essential, given the growing population of these patients, yet they are currently unavailable. Existing adult Society of Thoracic ... Full text Link to item Cite

Association of Urine Biomarkers With Acute Kidney Injury and Fluid Overload in Infants After Cardiac Surgery: A Single Center Ancillary Cohort of the Steroids to Reduce Systemic Inflammation After Infant Heart Surgery Trial.

Journal article Crit Care Explor · May 2023 UNLABELLED: To examine the association between three perioperative urine biomarker concentrations (urine cystatin C [uCysC], urine neutrophil gelatinase-associated lipocalin [uNGAL], and urine kidney injury molecule 1 [uKIM-1]), and cardiac surgery-associa ... Full text Link to item Cite

Prenatal Diagnosis, Management, and Treatment of Fetal Cardiac Disease.

Journal article Neoreviews · May 1, 2023 Prenatal diagnosis of congenital heart disease makes it possible to optimize and coordinate care of the fetus and pregnant person. Benefits encompass the full spectrum of pre- and perinatal care, from counseling to optimization of pregnancy care and fetal ... Full text Link to item Cite

Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study.

Journal article Diagnostics (Basel) · April 30, 2023 Patients with hypoplastic left heart syndrome who have been palliated with the Fontan procedure are at risk for adverse neurodevelopmental outcomes, lower quality of life, and reduced employability. We describe the methods (including quality assurance and ... Full text Link to item Cite

Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study.

Journal article medRxiv · April 17, 2023 UNLABELLED: Patients with hypoplastic left heart syndrome who have been palliated with the Fontan procedure are at risk for adverse neurodevelopmental outcomes, lower quality of life, and reduced employability. We describe the methods (including quality as ... Full text Link to item Cite

Variation in Case-Mix Across Hospitals: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · February 2023 BACKGROUND: The Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database was queried to document variation of patient characteristics, procedure types, and programmatic case-mix. METHODS: All index cardiac operations in patients less than 18 ye ... Full text Link to item Cite

Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates.

Journal article Congenit Heart Dis · 2023 BACKGROUND: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intraoperative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. METHODS ... Full text Link to item Cite

Methylprednisolone for Heart Surgery in Infants - A Randomized, Controlled Trial.

Journal article N Engl J Med · December 8, 2022 BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS: We conducted a multicenter, prospective, randomized, p ... Full text Link to item Cite

The pediatric heart network's study on long-term outcomes of children with HLHS and the impact of Norwood Shunt type in the single ventricle reconstruction trial cohort (SVRIII): Design and adaptations.

Journal article Am Heart J · December 2022 BACKGROUND: The Single Ventricle Reconstruction (SVR) Trial was the first randomized clinical trial of a surgical approach for treatment of congenital heart disease. Infants with hypoplastic left heart syndrome (HLHS) and other single right ventricle (RV) ... Full text Link to item Cite

Congenitally Corrected Transposition Cardiac Surgery: Society of Thoracic Surgeons Database Analysis.

Journal article Ann Thorac Surg · November 2022 BACKGROUND: Congenitally corrected transposition of the great arteries (ccTGA) has many management strategies, with the emergence of anatomic repair increasing the available surgical options. Contemporary surgical practices have not been described in multi ... Full text Link to item Cite

Acute Cardiac Care for Neonatal Heart Disease.

Journal article Pediatrics · November 1, 2022 This manuscript is one component of a larger series of articles produced by the Neonatal Cardiac Care Collaborative that are published in this supplement of Pediatrics. In this review article, we summarize the contemporary physiologic principles, evaluatio ... Full text Link to item Cite

Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider.

Journal article J Am Heart Assoc · September 6, 2022 The burden of patent ductus arteriosus (PDA) continues to be significant. In view of marked differences in preterm infants versus more mature, term counterparts (viewed on a continuum with adolescent and adult patients), mechanisms regulating ductal patenc ... Full text Link to item Cite

A systematic review of clinical study evidence for pulmonary vasodilator therapy following surgery with cardiopulmonary bypass in children with CHD.

Journal article Cardiol Young · September 2022 OBJECTIVES: Complications from pulmonary hypertension are one of the leading contributors to morbidity and mortality post-cardiopulmonary bypass surgery in children with CHD. Pulmonary vasodilator therapies are commonly used post-operatively, but the optim ... Full text Link to item Cite

Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease.

Journal article CJC Pediatr Congenit Heart Dis · August 2022 BACKGROUND: The impact of adjunctive anti-inflammatory treatment on outcomes for patients with Kawasaki disease (KD) and coronary artery aneurysms (CAAs) is unknown. METHODS: Using data from the International KD Registry in patients with ≥ medium CAA we ev ... Full text Link to item Cite

Postoperative Renal Failure, Shunt Type, and Mortality After Norwood Palliation.

Journal article Ann Thorac Surg · June 2022 BACKGROUND: The Single Ventricle Reconstruction Trial demonstrated increased risk of death or heart transplant 1 year after Norwood among subjects randomly assigned to modified Blalock-Taussig shunts compared with right ventricle to pulmonary artery (RV-PA ... Full text Link to item Cite

Association Between Digoxin Use and Cardiac Function in Infants With Single-Ventricle Congenital Heart Disease During the Interstage Period.

Journal article Pediatr Crit Care Med · June 1, 2022 OBJECTIVES: To examine the association between digoxin use and cardiac function assessed by echocardiographic indices in infants with single-ventricle (SV) congenital heart disease (CHD) during the interstage period. DESIGN: Retrospective cohort study. SET ... Full text Link to item Cite

Evolving Cost-Quality Relationship in Pediatric Heart Surgery.

Journal article Ann Thorac Surg · March 2022 BACKGROUND: For the more than 40,000 children in the United States undergoing congenital heart surgery annually, the relationship between hospital quality and costs remains unclear. Prior studies report conflicting results and clinical outcomes have contin ... Full text Link to item Cite

Variation in Pharmacologic Management of Patients with Kawasaki Disease with Coronary Artery Aneurysms.

Journal article J Pediatr · January 2022 OBJECTIVE: To evaluate practice variation in pharmacologic management in the International Kawasaki Disease Registry (IKDR). STUDY DESIGN: Practice variation in intravenous immunoglobulin (IVIG) therapy, anti-inflammatory agents, statins, beta-blockers, an ... Full text Link to item Cite

Association between Z-score for birth weight and postoperative outcomes in neonates and infants with congenital heart disease.

Journal article J Thorac Cardiovasc Surg · December 2021 OBJECTIVE: We hypothesized that infants with fetal growth restrictions have increased mortality and morbidity after congenital heart disease surgery. METHODS: The study included patients in The Society of Thoracic Surgeons Congenital Heart Surgery Database ... Full text Link to item Cite

Postoperative Hematocrit and Adverse Outcomes in Pediatric Cardiac Surgery Patients: A Cross-Sectional Study From the Society of Thoracic Surgeons and Congenital Cardiac Anesthesia Society Database Collaboration.

Journal article Anesth Analg · November 1, 2021 BACKGROUND: We sought to examine potential associations between pediatric postcardiac surgical hematocrit values and postoperative complications or mortality. METHODS: A retrospective, cross-sectional study from the Society of Thoracic Surgeons Congenital ... Full text Link to item Cite

Decline of increased risk donor offers increases waitlist mortality in paediatric heart transplantation.

Journal article Cardiol Young · August 2021 BACKGROUND: Increased risk donors in paediatric heart transplantation have characteristics that may increase the risk of infectious disease transmission despite negative serologic testing. However, the risk of disease transmission is low, and refusing an I ... Full text Link to item Cite

The Evolving Surgical Burden of Fontan Failure: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · July 2021 BACKGROUND: Fontan failure often requires surgical therapy in the form of Fontan revision or heart transplantation. We sought to characterize national trends in the surgical burden of Fontan failure and identify risk factors for adverse outcomes. METHODS: ... Full text Link to item Cite

Diaphragm Paralysis After Pediatric Cardiac Surgery: An STS Congenital Heart Surgery Database Study.

Journal article Ann Thorac Surg · July 2021 BACKGROUND: Previous single-center studies of diaphragm paralysis (DP) after pediatric cardiac surgery report incidence of 0.3% to 12.8% and associate DP with respiratory complications, prolonged ventilation and length of stay, and mortality. To better def ... Full text Link to item Cite

Transition to Ductal Stenting for Single Ventricle Patients Led to Improved Survival: An Institutional Case Series.

Journal article World J Pediatr Congenit Heart Surg · July 2021 BACKGROUND: The use of systemic-to-pulmonary shunts (SPS) in neonates with single ventricle heart defects and ductal-dependent pulmonary blood flow (ddPBF) was historically associated with high morbidity and mortality at our center. As a result, we transit ... Full text Link to item Cite

A systematic review of the evidence supporting post-operative medication use in congenital heart disease.

Journal article Cardiol Young · May 2021 BACKGROUND: Targeted drug development efforts in patients with CHD are needed to standardise care, improve outcomes, and limit adverse events in the post-operative period. To identify major gaps in knowledge that can be addressed by drug development effort ... Full text Link to item Cite

A systematic review of the evidence supporting post-operative diuretic use following cardiopulmonary bypass in children with Congenital Heart Disease.

Journal article Cardiol Young · May 2021 BACKGROUND: Paediatric cardiac surgery on cardiopulmonary bypass induces substantial physiologic changes that contribute to post-operative morbidity and mortality. Fluid overload and oedema are prevalent complications, routinely treated with diuretics. The ... Full text Link to item Cite

Tracheal surgery for airway anomalies associated with increased mortality in pediatric patients undergoing heart surgery: Society of Thoracic Surgeons Database analysis.

Journal article J Thorac Cardiovasc Surg · March 2021 OBJECTIVES: Airway anomalies are common in children with cardiac disease but with an unquantified impact on outcomes. We sought to define the association between airway anomalies and tracheal surgery with cardiac surgery outcomes using the Society of Thora ... Full text Link to item Cite

Updating an Empirically Based Tool for Analyzing Congenital Heart Surgery Mortality.

Journal article World J Pediatr Congenit Heart Surg · March 2021 OBJECTIVES: STAT Mortality Categories (developed 2009) stratify congenital heart surgery procedures into groups of increasing mortality risk to characterize case mix of congenital heart surgery providers. This update of the STAT Mortality Score and Categor ... Full text Link to item Cite

Comparison Between Currently Recommended Long-Term Medical Management of Coronary Artery Aneurysms After Kawasaki Disease and Actual Reported Management in the Last Two Decades.

Journal article Pediatr Cardiol · March 2021 In the 2017 American Heart Association (AHA) Kawasaki disease (KD) guidelines, risk levels (RLs) for long-term management are defined by both maximal and current coronary artery (CA) dimensions normalized as z-scores. We sought to determine the degree to w ... Full text Link to item Cite

Outcomes of Operator-Directed Sedation and Anesthesiologist Care in the Pediatric/Congenital Catheterization Laboratory: A Study Utilizing Data From the IMPACT Registry.

Journal article JACC Cardiovasc Interv · February 22, 2021 OBJECTIVES: The objective of this study was to assess contemporary use of operator directed sedation (ODS) and anesthesiologist care (AC) in the pediatric/congenital cardiac catheterization laboratory (PCCL), specifically evaluating whether the use of oper ... Full text Link to item Cite

An evidence-based review of the use of vasoactive and inotropic medications in post-operative paediatric patients after cardiac surgery with cardiopulmonary bypass from 2000 to 2020.

Journal article Cardiol Young · December 2020 BACKGROUND: Infants with moderate-to-severe CHD frequently undergo cardiopulmonary bypass surgery in childhood. Morbidity and mortality are highest in those who develop post-operative low cardiac output syndrome. Vasoactive and inotropic medications are ma ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2020 Update on Outcomes and Research.

Journal article Ann Thorac Surg · December 2020 The Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database (CHSD) continues to be a highly regarded, comprehensive clinical outcomes database that captures more than 90% of all congenital heart surgery cases in the United States and has more ... Full text Link to item Cite

National Variation in Congenital Heart Surgery Outcomes.

Journal article Circulation · October 6, 2020 BACKGROUND: Optimal strategies to improve national congenital heart surgery outcomes and reduce variability across hospitals remain unclear. Many policy and quality improvement efforts have focused primarily on higher-risk patients and mortality alone. Imp ... Full text Link to item Cite

Estimating Resource Utilization in Congenital Heart Surgery.

Journal article Ann Thorac Surg · September 2020 BACKGROUND: Optimal methods to assess resource utilization in congenital heart surgery remain unclear. We compared traditional cost-to-charge ratio methods with newer standardized cost methods that aim to more directly assess resources consumed. METHODS: C ... Full text Link to item Cite

A Randomized, Controlled Pharmacokinetic and Pharmacodynamics Trial of Ambrisentan After Fontan Surgery.

Journal article Pediatr Crit Care Med · September 2020 OBJECTIVES: To determine the pharmacokinetics, pharmacodynamics, and safety of the hepatically metabolized endothelin receptor antagonist, ambrisentan in children after Fontan surgery. DESIGN: Prospective, randomized, double-blind, placebo-controlled pharm ... Full text Link to item Cite

Medium-Term Complications Associated With Coronary Artery Aneurysms After Kawasaki Disease: A Study From the International Kawasaki Disease Registry.

Journal article J Am Heart Assoc · August 4, 2020 Background Coronary artery aneurysms (CAAs) may occur after Kawasaki disease (KD) and lead to important morbidity and mortality. As CAA in patients with KD are rare and heterogeneous lesions, prognostication and risk stratification are difficult. We sought ... Full text Link to item Cite

Overcoming underpowering: Trial simulations and a global rank end point to optimize clinical trials in children with heart disease.

Journal article Am Heart J · August 2020 BACKGROUND: Randomized controlled trials (RCTs) in children with heart disease are challenging and therefore infrequently performed. We sought to improve feasibility of perioperative RCTs for this patient cohort using data from a large, multicenter clinica ... Full text Link to item Cite

Palliating Premature Infants With Obstructed Total Anomalous Pulmonary Venous Connection via Catheterization.

Journal article World J Pediatr Congenit Heart Surg · July 2020 Obstructed total anomalous pulmonary venous connection (TAPVC) involves anomalous drainage of all pulmonary veins to a location other than the left atrium and typically causes significant respiratory symptoms requiring urgent surgical repair. Premature inf ... Full text Link to item Cite

Associations between anthropometric indices and outcomes of congenital heart operations in infants and young children: An analysis of data from the Society of Thoracic Surgeons Database.

Journal article Am Heart J · June 2020 BACKGROUND: Children with congenital heart disease are at risk for growth failure due to inadequate nutrient intake and increased metabolic demands. We examined the relationship between anthropometric indices of nutrition (height-for-age z-score [HAZ], wei ... Full text Link to item Cite

Registry-based trials: a potential model for cost savings?

Journal article Cardiol Young · June 2020 BACKGROUND/AIMS: Registry-based trials have emerged as a potentially cost-saving study methodology. Early estimates of cost savings, however, conflated the benefits associated with registry utilisation and those associated with other aspects of pragmatic t ... Full text Link to item Cite

Preprocedural three-dimensional planning aids in transcatheter ductal stent placement: A single-center experience.

Journal article Catheter Cardiovasc Interv · May 1, 2020 OBJECTIVES: Describe the use of three-dimensional (3D) patent ductus arteriosus (PDA) modeling to better define ductal anatomy to improve preprocedural planning for ductal stent placement. BACKGROUND: Ductal stenting is an alternative to surgical shunting ... Full text Link to item Cite

Pulmonary Valve Endocarditis: The Potential Utility of Multimodal Imaging Prior to Surgery.

Journal article World J Pediatr Congenit Heart Surg · March 2020 BACKGROUND: The presence of echocardiographic (echo) evidence is a major criterion for the diagnosis of infective endocarditis (IE) by modified Duke criteria. Pulmonary valve (PV) IE, however, can be challenging to identify by echo. We sought to evaluate t ... Full text Link to item Cite

Results of the FUEL Trial.

Journal article Circulation · February 25, 2020 BACKGROUND: The Fontan operation creates a total cavopulmonary connection, a circulation in which the importance of pulmonary vascular resistance is magnified. Over time, this circulation leads to deterioration of cardiovascular efficiency associated with ... Full text Link to item Cite

Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial.

Journal article Am Heart J · February 2020 For decades, physicians have administered corticosteroids in the perioperative period to infants undergoing heart surgery with cardiopulmonary bypass (CPB) to reduce the postoperative systemic inflammatory response to CPB. Some question this practice becau ... Full text Link to item Cite

Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass.

Journal article CPT Pharmacometrics Syst Pharmacol · December 2019 Methylprednisolone is used in neonates to modulate cardiopulmonary bypass (CPB)-induced inflammation, but optimal dosing and exposure are unknown. We used plasma methylprednisolone and interleukin (IL)-6 and IL-10 concentrations from neonates enrolled in a ... Full text Link to item Cite

Estimating radiation exposure during paediatric cardiac catheterisation: a potential for radiation reduction with air gap technique.

Journal article Cardiol Young · December 2019 INTRODUCTION: The air gap technique (AGT) is an approach to radiation dose optimisation during fluoroscopy where an "air gap" is used in place of an anti-scatter grid to reduce scatter irradiation. The AGT is effective in adults but remains largely unteste ... Full text Link to item Cite

Management of Pulmonary Arterial Hypertension in the Pediatric Patient.

Journal article Curr Cardiol Rep · November 28, 2019 PURPOSE OF REVIEW: Pediatric pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality. Herein we review the diagnosis and classification for pediatric PAH and detail the current therapeutic options available for use in t ... Full text Link to item Cite

A Genocentric Approach to Discovery of Mendelian Disorders.

Journal article Am J Hum Genet · November 7, 2019 The advent of inexpensive, clinical exome sequencing (ES) has led to the accumulation of genetic data from thousands of samples from individuals affected with a wide range of diseases, but for whom the underlying genetic and molecular etiology of their cli ... Full text Open Access Link to item Cite

Congenital Heart Surgery Outcomes in Turner Syndrome: The Society of Thoracic Surgeons Database Analysis.

Journal article Ann Thorac Surg · November 2019 BACKGROUND: Turner syndrome (TS) is a genetic syndrome characterized by monosomy X (45,XO) in phenotypic females and is commonly associated with congenital heart disease. We sought to describe the distribution, mortality, and morbidity of congenital heart ... Full text Link to item Cite

A Study of Practice Behavior for Endotracheal Intubation Site for Children With Congenital Heart Disease Undergoing Surgery: Impact of Endotracheal Intubation Site on Perioperative Outcomes-An Analysis of the Society of Thoracic Surgeons Congenital Cardiac Anesthesia Society Database.

Journal article Anesth Analg · October 2019 BACKGROUND: In adults undergoing cardiopulmonary bypass surgery, oral intubation is typically preferred over nasal intubation due to reduced risk of sinusitis and infection. In children, nasal intubation is more common and sometimes preferred due to percei ... Full text Open Access Link to item Cite

Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial.

Journal article Cardiol Young · October 2019 BACKGROUND: While echocardiographic parameters are used to quantify ventricular function in infants with single ventricle physiology, there are few data comparing these to invasive measurements. This study correlates echocardiographic measures of diastolic ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2019 Update on Research.

Journal article Ann Thorac Surg · September 2019 As the largest congenital and pediatric cardiac surgical clinical data registry in the world, The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) serves as a platform for reporting of outcomes and for quality improvement. In addit ... Full text Link to item Cite

Refining The Society of Thoracic Surgeons Congenital Heart Surgery Database Mortality Risk Model With Enhanced Risk Adjustment for Chromosomal Abnormalities, Syndromes, and Noncardiac Congenital Anatomic Abnormalities.

Journal article Ann Thorac Surg · August 2019 BACKGROUND: The Society of Thoracic Surgeons Congenital Heart Surgery Database Mortality Risk Model adjusts not only for procedure and age group pairings but also for additional patient factors, including the binary presence or absence of a chromosomal abn ... Full text Link to item Cite

Cardiac Surgery in Patients With Trisomy 13 and 18: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article J Am Heart Assoc · July 2, 2019 Background Congenital heart disease is common in patients with Trisomy 13 (T13) and Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We describe the landscape of surgical management across the United States, perioper ... Full text Link to item Cite

Readmission After Pediatric Cardiothoracic Surgery: An Analysis of The Society of Thoracic Surgeons Database.

Journal article Ann Thorac Surg · June 2019 BACKGROUND: Hospital readmission after pediatric cardiac surgery is incompletely understood. This study analyzed data from The Society of Thoracic Surgeons Congenital Heart Surgery Database to determine prevalence, to describe patient characteristics, and ... Full text Link to item Cite

Postoperative Transcatheter Interventions in Children Undergoing Congenital Heart Surgery.

Journal article Circ Cardiovasc Interv · June 2019 Background Postoperative transcatheter interventions (TCIs) are performed after congenital heart surgery to treat residual or recurrent anatomic lesions. We used the Society of Thoracic Surgeons Congenital Heart Surgery Database to evaluate rates of postop ... Full text Link to item Cite

Prenatal Diagnosis Influences Preoperative Status in Neonates with Congenital Heart Disease: An Analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Pediatr Cardiol · March 2019 The early postnatal course for a newborn with critical congenital heart disease (CHD) can be negatively impacted if diagnosis is delayed. Despite this, there continues to be inconsistent evidence regarding potential benefits associated with prenatal diagno ... Full text Link to item Cite

Routine postprocedure ultrasound increases rate of detection of femoral arterial thrombosis in infants after cardiac catheterization.

Journal article Catheter Cardiovasc Interv · March 1, 2019 OBJECTIVES: To examine the effect of implementing postcatheterization ultrasound (US) on femoral arterial thrombosis detection rates and factors associated with thrombosis in infants. BACKGROUND: Although femoral arterial thrombosis is an uncommon complica ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2019 Update on Outcomes and Quality.

Journal article Ann Thorac Surg · March 2019 The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive clinical outcomes registry that captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of Th ... Full text Link to item Cite

The Congenital Heart Technical Skill Study: Rationale and Design.

Journal article World J Pediatr Congenit Heart Surg · March 2019 BACKGROUND: We report the rationale and design for a peer-evaluation protocol of attending congenital heart surgeon technical skill using direct video observation. METHODS: All surgeons contributing data to The Society of Thoracic Surgeons-Congenital Heart ... Full text Link to item Cite

Development of a Congenital Heart Surgery Composite Quality Metric: Part 2-Analytic Methods.

Journal article Ann Thorac Surg · February 2019 BACKGROUND: We describe the statistical methods and results related to development of the first congenital heart surgery composite quality measure. METHODS: The composite measure was developed using The Society of Thoracic Surgeons Congenital Heart Surgery ... Full text Link to item Cite

Development of a Congenital Heart Surgery Composite Quality Metric: Part 1-Conceptual Framework.

Journal article Ann Thorac Surg · February 2019 BACKGROUND: Current pediatric and congenital heart surgery quality measures focus on operative mortality, and numerous stakeholders are interested in more comprehensive measures. This report describes the background, rationale, and conceptual framework rel ... Full text Link to item Cite

Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.

Journal article Am J Hum Genet · January 3, 2019 The use of whole-exome and whole-genome sequencing has been a catalyst for a genotype-first approach to diagnostics. Under this paradigm, we have implemented systematic sequencing of neonates and young children with a suspected genetic disorder. Here, we r ... Full text Open Access Link to item Cite

Validation and refinement of the catheterization RISk score for pediatrics (CRISP score): An analysis from the congenital cardiac interventional study consortium.

Journal article Catheter Cardiovasc Interv · January 1, 2019 OBJECTIVES: To externally validate the CRISP score, and determine if refinements might improve clinical utility. BACKGROUND: The CRISP score estimates risk of serious adverse events (SAEs) for pediatric catheterization. METHODS: Pediatric (age < 18) proced ... Full text Link to item Cite

The Prevalence and Impact of Congenital Diaphragmatic Hernia Among Patients Undergoing Surgery for Congenital Heart Disease.

Journal article Semin Thorac Cardiovasc Surg · 2019 There has not been a multicenter investigation to elucidate the prevalence and impact of congenital diaphragmatic hernia (CDH) on children undergoing cardiac surgery. We investigated the prevalence of CDH across congenital cardiac diagnostic and procedural ... Full text Link to item Cite

Variability in radiation dose and image quality: A comparison across fluoroscopy-system vendors, generations of equipment and institutions.

Journal article Catheter Cardiovasc Interv · December 1, 2018 OBJECTIVES: To evaluate differences in radiation dose and image quality across institutions, fluoroscope vendors and generations of fluoroscopes for pediatric cardiac catheterization. BACKGROUND: Increased recognition of the potentially harmful effects of ... Full text Link to item Cite

National Benchmarks for Proportions of Patients Receiving Blood Transfusions During Pediatric and Congenital Heart Surgery: An Analysis of the STS Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · October 2018 BACKGROUND: To determine national benchmarks and assess variability across centers, The Society of Thoracic Surgeons Congenital Heart Surgery Database was analyzed to document proportions of patients receiving intraoperative transfusion of packed red blood ... Full text Link to item Cite

Surgical Management and Outcomes of Ebstein Anomaly in Neonates and Infants: A Society of Thoracic Surgeons Congenital Heart Surgery Database Analysis.

Journal article Ann Thorac Surg · September 2018 BACKGROUND: Ebstein anomaly (EA) encompasses a broad spectrum of morphology and clinical presentation. Those who are symptomatic early in infancy are generally at highest risk, but there are limited data regarding multicentric practice patterns and outcome ... Full text Link to item Cite

Clinical pharmacology considerations for children supported with ventricular assist devices.

Journal article Cardiol Young · September 2018 The ventricular assist device is being increasingly used as a "bridge-to-transplant" option in children with heart failure who have failed medical management. Care for this medically complex population must be optimised, including through concomitant pharm ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2018 Update on Research.

Journal article Ann Thorac Surg · September 2018 The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) is the largest congenital and pediatric cardiac surgical clinical data registry in the world. The most recent biannual feedback report to participants includes analysis of data s ... Full text Link to item Cite

Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery.

Journal article JAMA Pediatr · July 1, 2018 IMPORTANCE: Acute kidney injury (AKI) is a common and serious complication for pediatric cardiac surgery patients associated with increased morbidity, mortality, and length of stay. Current strategies focus on risk reduction and early identification becaus ... Full text Link to item Cite

Hybrid Palliation: Outcomes After the Comprehensive Stage 2 Procedure.

Journal article Ann Thorac Surg · May 2018 BACKGROUND: The comprehensive stage 2 procedure (CS2) follows initial hybrid stage 1 palliation for patients with single-ventricle physiology. The goal of this study was to describe CS2 outcomes and differences between survivors of CS2 (s-CS2) and nonsurvi ... Full text Link to item Cite

Associations Between Unplanned Cardiac Reinterventions and Outcomes After Pediatric Cardiac Operations.

Journal article Ann Thorac Surg · April 2018 BACKGROUND: After pediatric heart operations, we sought to determine the incidence of unplanned cardiac reinterventions during the same hospitalization, assess risk factors for these reinterventions, and explore associations between reinterventions and out ... Full text Link to item Cite

Shunt Failure-Risk Factors and Outcomes: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · March 2018 BACKGROUND: Systemic-to-pulmonary shunt failure is a potentially catastrophic complication. We analyzed a large multicenter clinical registry to describe the prevalence and evaluate risk factors. METHODS: Infants (aged ≤365 days) undergoing shunt operation ... Full text Link to item Cite

Rapid regression of large cardiac rhabdomyomas in neonates after sirolimus therapy.

Journal article Cardiol Young · March 2018 Cardiac rhabdomyomas are the most common tumours in children and are typically seen in association with the tuberous sclerosis complex. Although benign and often associated with spontaneous regression, in rare circumstances surgical resection is indicated ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2018 Update on Outcomes and Quality.

Journal article Ann Thorac Surg · March 2018 The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive registry of clinical outcomes that captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of ... Full text Link to item Cite

Image Gently Have-A-Heart Campaign.

Journal article J Am Coll Radiol · February 2018 Full text Link to item Cite

Radiation dose management for pediatric cardiac computed tomography: a report from the Image Gently 'Have-A-Heart' campaign.

Journal article Pediatr Radiol · January 2018 Children with congenital or acquired heart disease can be exposed to relatively high lifetime cumulative doses of ionizing radiation from necessary medical imaging procedures including radiography, fluoroscopic procedures including diagnostic and intervent ... Full text Link to item Cite

The Use of Echocardiography for Pediatric Patients Presenting with Syncope.

Journal article J Pediatr · November 2017 OBJECTIVES: To assess the frequency, yield, and cost of echocardiograms meeting "rarely appropriate" criteria. STUDY DESIGN: Retrospective, single-center study of pediatric patients presenting with syncope. Patients were categorized according to the approp ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2017 Update on Research.

Journal article Ann Thorac Surg · September 2017 The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) is the largest congenital and pediatric cardiac surgical clinical data registry in the world. It contains data pertaining to more than 435,000 total operations. The most recent b ... Full text Link to item Cite

Post-market surveillance to detect adverse events associated with Melody® valve implantation.

Journal article Cardiol Young · August 2017 OBJECTIVE: The aim of this study was to describe previously unrecognised or under-recognised adverse events associated with Melody® valve implantation. BACKGROUND: In rare diseases and conditions, it is typically not feasible to conduct large-scale safety ... Full text Link to item Cite

The impact of femoral arterial thrombosis in paediatric cardiac catheterisation: a national study.

Journal article Cardiol Young · July 2017 BACKGROUND: Previous studies have identified risk factors for femoral arterial thrombosis after paediatric cardiac catheterisation, but none of them have evaluated the clinical and economic significance of this complication at the population level. Therefo ... Full text Link to item Cite

Evaluating Appropriate Use of Pediatric Echocardiograms for Chest Pain in Outpatient Clinics.

Journal article J Am Soc Echocardiogr · July 2017 BACKGROUND: Echocardiography is often used in the evaluation of pediatric chest pain, but the incidence of cardiac pathology is low. In 2014, the American College of Cardiology published appropriate use criteria (AUC) for echocardiography including recomme ... Full text Link to item Cite

Radiation Safety in Children With Congenital and Acquired Heart Disease: A Scientific Position Statement on Multimodality Dose Optimization From the Image Gently Alliance.

Journal article JACC Cardiovasc Imaging · July 2017 There is a need for consensus recommendations for ionizing radiation dose optimization during multimodality medical imaging in children with congenital and acquired heart disease (CAHD). These children often have complex diseases and may be exposed to a re ... Full text Link to item Cite

Association of Surgeon Age and Experience With Congenital Heart Surgery Outcomes.

Journal article Circ Cardiovasc Qual Outcomes · July 2017 BACKGROUND: Surgeon experience concerns both families of children with congenital heart disease and medical providers. Relationships between surgeon seniority and patient outcomes are often assumed, yet there are little data. METHODS AND RESULTS: This nati ... Full text Link to item Cite

Comparison of right ventricle-pulmonary artery shunt position in the Single Ventricle Reconstruction trial.

Journal article J Thorac Cardiovasc Surg · June 2017 OBJECTIVE: Placement of a right ventricle-pulmonary artery shunt to the left or right of the neoaorta may influence reinterventions, pulmonary artery development, and survival after the Norwood procedure because of differences in shunt and pulmonary artery ... Full text Link to item Cite

Trends in infective endocarditis hospitalisations at United States children's hospitals from 2003 to 2014: impact of the 2007 American Heart Association antibiotic prophylaxis guidelines.

Journal article Cardiol Young · May 2017 OBJECTIVE: National organisations in several countries have recently released more restrictive guidelines for infective endocarditis prophylaxis, including the American Heart Association 2007 guidelines. Initial studies demonstrated no change in infective ... Full text Link to item Cite

Impact of imaging approach on radiation dose and associated cancer risk in children undergoing cardiac catheterization.

Journal article Catheter Cardiovasc Interv · April 2017 OBJECTIVES: To quantify the impact of image optimization on absorbed radiation dose and associated risk in children undergoing cardiac catheterization. BACKGROUND: Various imaging and fluoroscopy system technical parameters including camera magnification, ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2017 Update on Outcomes and Quality.

Journal article Ann Thorac Surg · March 2017 The Society of Thoracic Surgeons Congenital Heart Surgery Database is the largest congenital and pediatric cardiac surgical clinical data registry in the world. It is the platform for all activities of The Society of Thoracic Surgeons related to the analys ... Full text Link to item Cite

Congenital Heart Disease in Premature Infants 25-32 Weeks' Gestational Age.

Journal article J Pediatr · February 2017 OBJECTIVE: To determine the birth prevalence of congenital heart defects (CHDs) across the spectrum of common defects in very/extremely premature infants and to compare mortality rates between premature infants with and without CHDs. STUDY DESIGN: The Kids ... Full text Link to item Cite

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.

Journal article Ther Drug Monit · February 2017 BACKGROUND: Drugs that exhibit close margins between therapeutic and toxic blood concentrations are considered to have a narrow therapeutic index (NTI). The Food and Drug Administration has proposed that NTI drugs should have more stringent bioequivalence ... Full text Link to item Cite

Academic Outcomes in Children With Congenital Heart Defects: A Population-Based Cohort Study.

Journal article Circ Cardiovasc Qual Outcomes · February 2017 BACKGROUND: Most studies evaluating neurocognitive outcomes in children with congenital heart defects (CHD) have focused on high-risk patients or used specialized, resource-intensive testing. To determine the association of CHD with academic outcomes and c ... Full text Link to item Cite

Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012.

Journal article Cardiol Young · January 2017 OBJECTIVE: The aim of the study was to evaluate the trends in respiratory syncytial virus-related hospitalisations and associated outcomes in children with haemodynamically significant heart disease in the United States of America. Study design The Kids' I ... Full text Link to item Cite

Assessment of Growth 6 Years after the Norwood Procedure.

Journal article J Pediatr · January 2017 UNLABELLED: At 6 years of age, patients with hypoplastic left heart syndrome had mean age-adjusted z-scores for weight and height below the normative population, and body mass index was similar to the normative population. Males had the greatest increase i ... Full text Link to item Cite

Characteristics of pediatric pulmonary hypertension trials registered on ClinicalTrials.gov.

Journal article Pulm Circ · 2017 The investigation of pediatric pulmonary hypertension (PH) drugs has been identified as a high priority by the United States National Institutes of Health (NIH). Studying pediatric PH is challenging due to the rare and heterogeneous nature of the disease. ... Full text Open Access Link to item Cite

Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine.

Journal article Ther Drug Monit · December 2016 BACKGROUND: Defining a drug's therapeutic index (TI) is important for patient safety and regulating the development of generic drugs. For many drugs, the TI is unknown. A systematic approach was developed to characterize the TI of a drug using therapeutic ... Full text Link to item Cite

Abstract 12670: Variability in Radiation Dose and Image Quality: A Comparison Across Fluoroscopy-system Vendors and Generations of Equipment.

Journal article Circulation · November 11, 2016 INTRODUCTION: Increased recognition of the potentially harmful effects of ionizing radiation has spurred technological advances to reduce exposure during fluoroscopy. However there is currently little understanding of the dose-image quality (IQ) relationsh ... Link to item Cite

Prevalence of Noncardiac and Genetic Abnormalities in Neonates Undergoing Cardiac Operations: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · November 2016 BACKGROUND: Among patients with congenital heart disease (CHD), the coexistence of noncardiac congenital anatomic abnormalities (NC), genetic abnormalities (GA), and syndromes (S) may influence therapeutic strategies and outcomes. The appreciated prevalenc ... Full text Link to item Cite

Congenital Heart Surgery Case Mix Across North American Centers and Impact on Performance Assessment.

Journal article Ann Thorac Surg · November 2016 BACKGROUND: Performance assessment in congenital heart surgery is challenging due to the wide heterogeneity of disease. We describe current case mix across centers, evaluate methodology inclusive of all cardiac operations versus the more homogeneous subset ... Full text Link to item Cite

Delayed Sternal Closure in Infant Heart Surgery-The Importance of Where and When: An Analysis of the STS Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · November 2016 BACKGROUND: Delayed sternal closure (DSC) is commonly used to optimize hemodynamic stability after neonatal and infant heart surgery. We hypothesized that duration of sternum left open (SLO) was associated with rate of infection complications, and that loc ... Full text Link to item Cite

Critical Care Nursing's Impact on Pediatric Patient Outcomes.

Journal article Ann Thorac Surg · October 2016 BACKGROUND: Previous studies have demonstrated the effect of adult nursing skill mix, staffing ratios, and level of education on patient deaths, complication rates, and failure to rescue (FTR). To date, only one known study had examined the effect of nursi ... Full text Link to item Cite

Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients.

Journal article Ther Drug Monit · October 2016 BACKGROUND: Sirolimus, an immunosuppressive agent used in renal transplantation, can prevent allograft rejection. Identification of the therapeutic index (the ratio of minimum toxic concentration to minimum therapeutic concentration) for immunosuppresants ... Full text Link to item Cite

Cardiopulmonary resuscitation in hospitalized infants.

Journal article Early Hum Dev · October 2016 BACKGROUND: Hospitalized infants requiring cardiopulmonary resuscitation (CPR) represent a high-risk group. Recent data on risk factors for mortality following CPR in this population are lacking. AIMS: We hypothesized that infant demographic characteristic ... Full text Link to item Cite

Mortality Trends in Pediatric and Congenital Heart Surgery: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · October 2016 BACKGROUND: Previous analyses of The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database have demonstrated a reduction over time of risk-adjusted operative mortality after coronary artery bypass grafting. The STS Congenital Heart Surgery Data ... Full text Link to item Cite

Early Extubation After Repair of Tetralogy of Fallot and the Fontan Procedure: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · September 2016 BACKGROUND: There is increasing interest in reducing the duration of mechanical ventilation after pediatric cardiac operations. However, the contemporary use of an early extubation strategy and its effect on clinical outcomes is poorly understood. METHODS: ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2016 Update on Research.

Journal article Ann Thorac Surg · September 2016 The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) is the largest congenital and pediatric cardiac surgical clinical data registry in the world. With more than 400,000 total operations from nearly all centers performing pediatric ... Full text Link to item Cite

The Perioperative Use of Dexmedetomidine in Pediatric Patients with Congenital Heart Disease: An Analysis from the Congenital Cardiac Anesthesia Society-Society of Thoracic Surgeons Congenital Heart Disease Database.

Journal article Anesth Analg · September 2016 BACKGROUND: Dexmedetomidine is a selective α-2 receptor agonist with a sedative and cardiopulmonary profile that makes it an attractive anesthetic for pediatric patients with congenital heart disease (CHD). Although several smaller, single-center studies s ... Full text Link to item Cite

Variation in Perfusion Strategies for Neonatal and Infant Aortic Arch Repair: Contemporary Practice in the STS Congenital Heart Surgery Database.

Journal article World J Pediatr Congenit Heart Surg · September 2016 BACKGROUND: Regional cerebral perfusion (RCP) is used as an adjunct or alternative to deep hypothermic circulatory arrest (DHCA) for neonates and infants undergoing aortic arch repair. Clinical studies have not demonstrated clear superiority of either stra ... Full text Link to item Cite

Surgical Valvotomy Versus Balloon Valvuloplasty for Congenital Aortic Valve Stenosis: A Systematic Review and Meta-Analysis.

Journal article J Am Heart Assoc · August 8, 2016 BACKGROUND: Optimal initial treatment for congenital aortic valve stenosis in children remains unclear between balloon aortic valvuloplasty (BAV) and surgical aortic valvotomy (SAV). METHODS AND RESULTS: We performed a contemporary systematic review and me ... Full text Open Access Link to item Cite

Maladaptive aortic properties after the Norwood procedure: An angiographic analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial.

Journal article J Thorac Cardiovasc Surg · August 2016 OBJECTIVES: Aortic arch reconstruction in children with single ventricle lesions may predispose to circulatory inefficiency and maladaptive physiology leading to increased myocardial workload. We sought to describe neoaortic anatomy and physiology, risk fa ... Full text Link to item Cite

Transcatheter pulmonary embolectomy after fontan.

Journal article Catheter Cardiovasc Interv · April 2016 Pulmonary embolism (PE) is a significant cause of morbidity and mortality among hospitalized patients, and thrombolytics are the mainstay of treatment. However, for patients who fail or have contraindications to thrombolytic therapy, catheter-based therapi ... Full text Link to item Cite

Assessment of Quality of Life in Young Patients with Single Ventricle after the Fontan Operation.

Journal article J Pediatr · March 2016 OBJECTIVES: To assess self-reported quality of life (QOL) in a large multicenter cohort of adolescent and young adults surviving Fontan. STUDY DESIGN: Cross-sectional. The Pediatric Quality of Life Inventory (PedsQL) was administered to 408 survivors of Fo ... Full text Link to item Cite

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2016 Update on Outcomes and Quality.

Journal article Ann Thorac Surg · March 2016 The Society of Thoracic Surgeons Congenital Heart Surgery Database is the largest congenital and pediatric cardiac surgical clinical data registry in the world. It is the platform for all activities of The Society of Thoracic Surgeons related to the analys ... Full text Link to item Cite

Pharmacokinetics of intravenous sildenafil in children with palliated single ventricle heart defects: effect of elevated hepatic pressures.

Journal article Cardiol Young · February 2016 UNLABELLED: Aims Sildenafil is frequently prescribed to children with single ventricle heart defects. These children have unique hepatic physiology with elevated hepatic pressures, which may alter drug pharmacokinetics. We sought to determine the impact of ... Full text Link to item Cite

New approaches to reduce radiation exposure.

Journal article Trends Cardiovasc Med · January 2016 Exposure to ionizing radiation is associated with a long-term risk of health effects, including cancer. Radiation exposure to the U.S. population from cardiac imaging has increased markedly over the past three decades. Initiatives to reduce radiation expos ... Full text Link to item Cite

Differences in Eccentricity Index and Systolic-Diastolic Ratio in Extremely Low-Birth-Weight Infants with Bronchopulmonary Dysplasia at Risk of Pulmonary Hypertension.

Journal article Am J Perinatol · January 2016 OBJECTIVE: To compare the left ventricular eccentricity index (EI) and tricuspid valve systolic-diastolic (SD) ratio in infants at risk of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). STUDY DESIGN: Review of echocardiograms performed o ... Full text Link to item Cite

Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach.

Journal article Clin Neuropharmacol · 2016 OBJECTIVES: Our study aimed to determine whether data obtained from the medical literature can be used to estimate the therapeutic index of 5 antiepileptic drugs (AEDs): carbamazepine, lamotrigine, phenobarbital, phenytoin, and valproate. METHODS: We perfo ... Full text Link to item Cite

Characterization of MOSFET Dosimeter Angular Response Using a Spherical Phantom for Fluoroscopic Dosimetry.

Journal article Health Phys · January 2016 Metal-Oxide Semiconductor Field-Effect Transistor (MOSFET) dosimeters, placed in anthropomorphic phantoms, are a standard method for organ dosimetry in medical x-ray imaging applications. However, many x-ray applications, particularly fluoroscopy procedure ... Full text Link to item Cite

Coarctation of the aorta: Management from infancy to adulthood.

Journal article World J Cardiol · November 26, 2015 Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical sy ... Full text Link to item Cite

Estimating Mortality Risk for Adult Congenital Heart Surgery: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · November 2015 BACKGROUND: Adjustment for case mix is critical to accurate outcomes analysis in congenital heart surgery. Established tools encompass all age groups and are not specific to the growing population of adults undergoing congenital heart operations. We derive ... Full text Link to item Cite

Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants.

Journal article Pediatrics · August 2015 BACKGROUND AND OBJECTIVE: Prenatal diagnosis allows improved perioperative outcomes for fetuses with certain forms of congenital heart disease (CHD). Variability in prenatal diagnosis has been demonstrated in other countries, leading to efforts to improve ... Full text Link to item Cite

Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute.

Journal article Cardiol Young · August 2015 In the United States alone, ∼14,000 children are hospitalised annually with acute heart failure. The science and art of caring for these patients continues to evolve. The International Pediatric Heart Failure Summit of Johns Hopkins All Children's Heart In ... Full text Link to item Cite

Drug Dosing and Pharmacokinetics in Children With Obesity: A Systematic Review.

Journal article JAMA Pediatr · July 2015 IMPORTANCE: Obesity affects nearly one-sixth of US children and results in alterations to body composition and physiology that can affect drug disposition, possibly leading to therapeutic failure or toxic side effects. The depth of available literature reg ... Full text Link to item Cite

Benchmark Outcomes for Pulmonary Valve Replacement Using The Society of Thoracic Surgeons Databases.

Journal article Ann Thorac Surg · July 2015 BACKGROUND: As less invasive alternatives to surgical pulmonary valve replacement (PVR) are being refined and evaluated, there is a need for benchmark data concerning outcomes from surgical PVR. METHODS: We examined in-hospital outcomes from surgical PVR i ... Full text Link to item Cite

Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease.

Journal article Am J Perinatol · June 2015 OBJECTIVE: Infants with congenital heart disease (CHD) receiving prostaglandins (PGEs) may be at an increased risk for necrotizing enterocolitis (NEC). Enteral feeding may further increase the risk of NEC in these patients. We evaluated the incidence of NE ... Full text Link to item Cite

Adverse cardiac events in children with Williams syndrome undergoing cardiovascular surgery: An analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article J Thorac Cardiovasc Surg · June 2015 OBJECTIVE: Patients with Williams syndrome (WS) undergoing cardiac surgery are at risk for major adverse cardiac events (MACE). Prevalence and risk factors for such events have not been well described. We sought to define frequency and risk of MACE in pati ... Full text Link to item Cite

Treatment of supraventricular tachycardia in infants: Analysis of a large multicenter database.

Journal article Early Hum Dev · June 2015 OBJECTIVE: Supraventricular tachycardia (SVT) is the most common arrhythmia in infants. Infants are typically treated with antiarrhythmic medications, but there is a lack of evidence guiding management, thus exposing infants to risks of both inadequate the ... Full text Link to item Cite

Contemporary Outcomes of Surgical Repair of Total Anomalous Pulmonary Venous Connection in Patients With Heterotaxy Syndrome.

Journal article Ann Thorac Surg · June 2015 BACKGROUND: Total anomalous pulmonary venous connection (TAPVC) is prevalent in patients with atriovisceral heterotaxy. Although functionally univentricular heart defects are common in heterotaxy syndromes, the extent to which this association influences o ... Full text Link to item Cite

Stage 1 hybrid palliation for hypoplastic left heart syndrome--assessment of contemporary patterns of use: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article J Thorac Cardiovasc Surg · January 2015 OBJECTIVE: Hybrid palliation is an alternative to Norwood stage 1 for the initial management of hypoplastic left heart syndrome. Contemporary multicenter hybrid use and institutional/patient factors associated with hybrid use relative to the Norwood have n ... Full text Link to item Cite

Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension.

Journal article Drug Healthc Patient Saf · 2015 Sildenafil is a phosphodiesterase type-5 inhibitor approved for treatment of pulmonary arterial hypertension (PAH) in adults. Data from pediatric trials demonstrate a similar acute safety profile to the adult population but have raised concerns regarding t ... Full text Open Access Link to item Cite

A Novel early pregnancy assessment unit/Gynaecology assessment unit dashboard: An experience from a UK district general hospital.

Journal article J Obstet Gynaecol · 2015 The establishment of early pregnancy assessment units (EPAUs)/Gynaecology assessment units (GAUs) started more than 20 years ago in the UK to decrease hospital admissions of patients with early pregnancy problems. However, there are still wide variations i ... Full text Link to item Cite

Contemporary outcomes of complete atrioventricular septal defect repair: analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article J Thorac Cardiovasc Surg · December 2014 OBJECTIVE: Contemporary outcomes data for complete atrioventricular septal defect (CAVSD) repair are limited. We sought to describe early outcomes of CAVSD repair across a large multicenter cohort, and explore potential associations with patient characteri ... Full text Link to item Cite

Epidemiology and outcomes after in-hospital cardiac arrest after pediatric cardiac surgery.

Journal article Ann Thorac Surg · December 2014 BACKGROUND: Multicenter data regarding cardiac arrest in children undergoing heart operations are limited. We describe epidemiology and outcomes associated with postoperative cardiac arrest in a large multiinstitutional cohort. METHODS: Patients younger th ... Full text Link to item Cite

Clinical outcomes in very low birth weight infants with major congenital heart defects.

Journal article Early Hum Dev · December 2014 BACKGROUND: The combination of major congenital heart disease (CHD) and prematurity is associated with poor prognosis, but previous studies have not fully characterized morbidity and mortality in this population. We conducted a retrospective cohort study o ... Full text Link to item Cite

Cardiopulmonary Resuscitation in Hospitalized Infants

Journal article CIRCULATION · November 25, 2014 Link to item Cite

Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial.

Journal article J Am Coll Cardiol · November 11, 2014 BACKGROUND: In children with single right ventricular (RV) anomalies, changes in RV size and function may be influenced by shunt type chosen at the time of the Norwood procedure. OBJECTIVES: The study sought to identify shunt-related differences in echocar ... Full text Link to item Cite

Technical performance score is associated with outcomes after the Norwood procedure.

Journal article J Thorac Cardiovasc Surg · November 2014 OBJECTIVES: The technical performance score (TPS) has been reported in a single center study to predict the outcomes after congenital cardiac surgery. We sought to determine the association of the TPS with outcomes in patients undergoing the Norwood proced ... Full text Link to item Cite

Excess costs associated with complications and prolonged length of stay after congenital heart surgery.

Journal article Ann Thorac Surg · November 2014 BACKGROUND: While there is an increasing emphasis on both optimizing quality of care and reducing health care costs, there are limited data regarding how to best achieve these goals for common and resource-intense conditions such as congenital heart diseas ... Full text Link to item Cite

Impact of pre-stage II hemodynamics and pulmonary artery anatomy on 12-month outcomes in the Pediatric Heart Network Single Ventricle Reconstruction trial.

Journal article J Thorac Cardiovasc Surg · October 2014 OBJECTIVE: To compare the interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for the Pediatric Heart Network Single Ventricle Reconstruction trial. The trial, which randomized subjects to a modified Blalock-Taussig ... Full text Link to item Cite

Congenital heart operations performed in the first year of life: does geographic variation exist?

Journal article Ann Thorac Surg · September 2014 BACKGROUND: Geographic variations associated with surgical intervention for congenital heart disease are ill defined. This study uses a large clinical registry to assess frequency of surgical intervention for various infant congenital heart diseases overal ... Full text Link to item Cite

Surgeon and center volume influence on outcomes after arterial switch operation: analysis of the STS Congenital Heart Surgery Database.

Journal article Ann Thorac Surg · September 2014 BACKGROUND: The relative impact of center volume and of surgeon volume on early outcomes after the arterial switch operation (ASO) is incompletely understood. METHODS: Neonates in the Society of Thoracic Surgeons Congenital Heart Surgery Database (2005-201 ... Full text Link to item Cite

Cumulative radiation exposure and cancer risk estimation in children with heart disease.

Journal article Circulation · July 8, 2014 BACKGROUND: Children with heart disease are frequently exposed to imaging examinations that use ionizing radiation. Although radiation exposure is potentially carcinogenic, there are limited data on cumulative exposure and the associated cancer risk. We ev ... Full text Link to item Cite

Gestational age at birth and outcomes after neonatal cardiac surgery: an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal article Circulation · June 17, 2014 BACKGROUND: Gestational age at birth is a potentially important modifiable risk factor in neonates with congenital heart disease. We evaluated the relationship between gestational age and outcomes in a multicenter cohort of neonates undergoing cardiac surg ... Full text Link to item Cite

Characteristics of pediatric cardiovascular clinical trials registered on ClinicalTrials.gov.

Journal article Am Heart J · June 2014 BACKGROUND: ClinicalTrials.gov is an National Institutes of Health-sponsored registry of federally and privately funded trials. We sought to determine fundamental characteristics of registered pediatric cardiovascular trials (PCVTs). METHODS: A data set in ... Full text Link to item Cite

Risk factors for prolonged length of stay after the stage 2 procedure in the single-ventricle reconstruction trial.

Journal article J Thorac Cardiovasc Surg · June 2014 BACKGROUND: The single-ventricle reconstruction trial randomized patients with single right ventricle lesions to a modified Blalock-Taussig or right ventricle-to-pulmonary artery shunt at the Norwood. This analysis describes outcomes at the stage 2 procedu ... Full text Link to item Cite

Anti-hypertensive drugs in children and adolescents.

Journal article World J Cardiol · May 26, 2014 Worldwide the prevalence of essential hypertension in children and adolescents continues to increase. Traditionally providers have used "off-label" drugs to treat pediatric hypertension, meaning that rigorous clinical trials of these drugs have not been sp ... Full text Link to item Cite

Procedure-based complications to guide informed consent: analysis of society of thoracic surgeons-congenital heart surgery database.

Journal article Ann Thorac Surg · May 2014 BACKGROUND: Informed consent refers to the process by which physicians and patients engage in a dialogue to explain and comprehend the nature, alternatives, and risks of a procedure or course of therapy. The goal of this study is to better "inform the proc ... Full text Link to item Cite

The relationship of patient medical and laboratory characteristics to changes in functional health status in children and adolescents after the Fontan procedure.

Journal article Pediatr Cardiol · April 2014 Despite hypothesized concerns about deterioration beginning in adolescence, longitudinal data and associated factors regarding standardized assessment of physical functioning are not available for Fontan patients. Parents who participated in the Fontan Cro ... Full text Link to item Cite

Variation in congenital heart surgery costs across hospitals.

Journal article Pediatrics · March 2014 BACKGROUND: A better understanding of costs associated with common and resource-intense conditions such as congenital heart disease has become increasingly important as children's hospitals face growing pressure to both improve quality and reduce costs. We ... Full text Link to item Cite

Reoperations for pediatric and congenital heart disease: an analysis of the Society of Thoracic Surgeons (STS) congenital heart surgery database.

Journal article Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu · 2014 In this descriptive analysis, data in the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database pertaining to patients who underwent reoperative cardiac surgery were analyzed. Practice patterns and outcomes are described. Reoperative cardiac ... Full text Link to item Cite

Sildenafil exposure and hemodynamic effect after Fontan surgery.

Journal article Pediatr Crit Care Med · January 2014 OBJECTIVE: Determine sildenafil exposure and hemodynamic effect in children after Fontan single-ventricle surgery. DESIGN: Prospective dose-escalation trial. SETTING: Single-center pediatric catheterization laboratory. PATIENTS: Nine children post Fontan s ... Full text Link to item Cite

Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat.

Journal article J Vet Cardiol · September 2013 A hybrid surgical approach and balloon dilatation were performed successfully in a cat with cor triatriatum sinister and clinical signs of congestive heart failure. Left lateral thoracotomy was used to access the heart and cutting balloon followed by stand ... Full text Link to item Cite

Intervention for recoarctation in the single ventricle reconstruction trial: incidence, risk, and outcomes.

Journal article Circulation · August 27, 2013 BACKGROUND: Recoarctation after the Norwood procedure increases risk for mortality. The Single Ventricle Reconstruction (SVR) trial randomized subjects with a single right ventricle undergoing a Norwood procedure to a modified Blalock-Taussig shunt or a ri ... Full text Link to item Cite

Hospital variation in postoperative infection and outcome after congenital heart surgery.

Journal article Ann Thorac Surg · August 2013 BACKGROUND: Several initiatives aim to reduce postoperative infection across a variety of surgical patients as a means to improve overall quality of care and reduce variation across centers. However, the association of infection rates with hospital-level o ... Full text Link to item Cite

Sildenafil exposure and hemodynamic effect after stage II single-ventricle surgery.

Journal article Pediatr Crit Care Med · July 2013 OBJECTIVES: To determine sildenafil exposure and hemodynamic effect in children after stage II single-ventricle surgery. DESIGN: Prospective, dose escalation trial. SETTING: Single-center, pediatric catheterization laboratory. PATIENTS: Twelve children pos ... Full text Link to item Cite

A strategy for atrial septal defect closure in small children that eliminates long-term wall erosion risk.

Journal article Catheter Cardiovasc Interv · March 2013 Featured Publication OBJECTIVES: To evaluate feasibility, efficacy, and safety of an approach to atrial septal defect (ASD) occlusion in children ≤20 kg that eliminates cardiac wall erosion risk. BACKGROUND: Cardiac wall erosion is a potentially catastrophic complication of AS ... Full text Link to item Cite

Percutaneous interventions in high-risk patients following Mustard repair of transposition of the great arteries.

Journal article Catheter Cardiovasc Interv · November 15, 2012 Featured Publication OBJECTIVES: To assess safety, efficacy, and intermediate term outcomes of percutaneous interventions in Mustard patients. BACKGROUND: Baffle leaks and obstruction are present in 20% of Mustard survivors. Surgical reintervention is associated with high mort ... Full text Link to item Cite

Evaluation of pediatric near-infrared cerebral oximeter for cardiac disease.

Journal article Ann Thorac Surg · November 2012 BACKGROUND: Cerebral hypoxia-ischemia remains a complication in children with congenital heart disease. Near-infrared spectroscopy can be utilized at the bedside to detect cerebral hypoxia-ischemia. This study aimed to calibrate and validate an advanced te ... Full text Link to item Cite

Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial.

Journal article J Thorac Cardiovasc Surg · October 2012 Featured Publication OBJECTIVE: For infants with single ventricle malformations undergoing staged repair, interstage mortality is reported at 2% to 20%. The Single Ventricle Reconstruction trial randomized subjects with a single morphologic right ventricle undergoing a Norwood ... Full text Link to item Cite

Cause, timing, and location of death in the Single Ventricle Reconstruction trial.

Journal article J Thorac Cardiovasc Surg · October 2012 OBJECTIVES: The Single Ventricle Reconstruction trial randomized 555 subjects with a single right ventricle undergoing the Norwood procedure at 15 North American centers to receive either a modified Blalock-Taussig shunt or right ventricle-to-pulmonary art ... Full text Link to item Cite

Percutaneous pulmonary valve replacement

Journal article Progress in Pediatric Cardiology · May 1, 2012 Each year in the United States more than 4000 newborns are diagnosed with complex congenital heart disease involving right ventricular outflow tract obstruction. Despite advances in surgical techniques with right ventricle to pulmonary artery conduits, pro ... Full text Cite

Safety of cardiac devices in children

Journal article Progress in Pediatric Cardiology · May 1, 2012 Implanted cardiac devices have improved and prolonged the lives of countless children. Some of these devices have undergone vigorous pre-market assessment and are US Food and Drug Administration (FDA) approved for use in children; however, many devices are ... Full text Cite

Introduction

Journal article Progress in Pediatric Cardiology · May 1, 2012 Full text Cite

Isolated right subclavian artery arising from the right pulmonary artery via a right-sided ductus arteriosus with associated pulmonary steal phenomenon.

Journal article Cardiol Young · April 2012 Featured Publication We present a patient with DiGeorge syndrome and an isolated right subclavian artery arising from the right pulmonary artery via a right-sided ductus arteriosus. The patient showed a subclavian and pulmonary steal with perfusion of the right arm and right l ... Full text Link to item Cite

Percutaneous vascular stent implantation as treatment for central vascular obstruction due to fibrosing mediastinitis.

Journal article Circulation · April 5, 2011 Featured Publication BACKGROUND: Fibrosing Mediastinitis (FM) is a rare complication of infection with Histoplasma capsulatum that can lead to obstruction of pulmonary and systemic vasculature and large airways, often resulting in significant morbidity and mortality. Medical t ... Full text Link to item Cite

Complete resolution of systemic venous baffle obstruction and baffle leak using the Gore Excluder covered stent in two patients with transposition of the great arteries and prior Mustard procedure.

Journal article Catheter Cardiovasc Interv · November 15, 2010 Featured Publication We present two patients with a history of Mustard repair of transposition of the great arteries. Both patients presented with exertional limitation and demonstrated superior systemic venous baffle obstruction as well as multiple baffle leaks. In both patie ... Full text Link to item Cite

Assessment of pulmonary hypertension in the pediatric catheterization laboratory: current insights from the Magic registry.

Journal article Catheter Cardiovasc Interv · November 15, 2010 Featured Publication OBJECTIVES: To assess protocols, demographics, and hemodynamics in pediatric patients undergoing catheterization for pulmonary hypertension (PH). BACKGROUND: Pediatric specific data is limited on PH. METHODS: Review of the Mid-Atlantic Group of Interventio ... Full text Link to item Cite

Novel transatrial septoplasty technique for neonates with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum.

Journal article Pediatr Cardiol · May 2010 Featured Publication Two patients born with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum requiring emergent intervention are presented. For both patients, rapid septoplasty was performed using a hybrid approach involving direct atrial punct ... Full text Link to item Cite

Routine performance of endomyocardial biopsy decreases the incidence of orthotopic heart transplant for myocarditis.

Journal article J Heart Lung Transplant · December 2009 Featured Publication BACKGROUND: In critically ill children presenting with dilated cardiomyopathy (DCM), the presence of myocarditis predicts an improved chance of myocardial recovery. Noninvasive differentiation of myocarditis from other causes of DCM is difficult. However, ... Full text Link to item Cite

Pulmonary venous wedge pressure provides a safe and accurate estimate of pulmonary arterial pressure in children with shunt-dependent pulmonary blood flow.

Journal article Catheter Cardiovasc Interv · November 1, 2009 Featured Publication OBJECTIVES: To compare two methods of pulmonary arterial pressure measurement in children with shunt-dependent pulmonary blood flow. BACKGROUND: In children with shunt-dependent pulmonary blood flow, direct assessment of pulmonary arterial pressure require ... Full text Link to item Cite

Right-sided pulmonary venous obstruction between a right aortic arch and an amplatzer septal occlusion device following closure of a secundum atrial septal defect.

Journal article Pediatr Cardiol · August 2009 Featured Publication Right-sided pulmonary venous obstruction between a right aortic arch and an Amplatzer Septal Occluder device developed following closure of a large secundum atrial septal defect. The obstruction was not apparent on postprocedure transesophageal echocardiog ... Full text Link to item Cite

Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome.

Journal article Diabetes Care · May 2009 Featured Publication OBJECTIVE: This study tested the hypothesis that phosphodiesterase 5 inhibition alone or in combination with ACE inhibition improves glucose homeostasis and fibrinolysis in individuals with metabolic syndrome. RESEARCH DESIGN AND METHODS: Insulin sensitivi ... Full text Open Access Link to item Cite

Pediatric cardiomyopathies related to fatty acid metabolism

Journal article Progress in Pediatric Cardiology · April 1, 2008 Inborn errors of metabolism affecting the fatty acid ß-oxidation pathway lead to cardiomyopathy, arrhythmia, and sudden death. In this article, an overview of the clinical presentations, diagnosis, treatment, and long-term outcome is provided with an empha ... Full text Cite

Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition.

Journal article Hypertension · February 2008 To test the hypothesis that the bradykinin receptor 2 (BDKRB2) BE1+9/-9 polymorphism affects vascular responses to bradykinin, we measured the effect of intra-arterial bradykinin on forearm blood flow and tissue-type plasminogen activator (t-PA) release in ... Full text Link to item Cite

Low plasma concentrations of retinol and alpha-tocopherol in hematopoietic stem cell transplant recipients: the effect of mucositis and the risk of infection.

Journal article Am J Clin Nutr · December 2002 BACKGROUND: Although vitamin deficiencies are rare in the United States, acute reductions in concentrations of plasma retinol (vitamin A) or alpha-tocopherol (vitamin E) have been associated with impaired immune responses in some clinical settings. OBJECTI ... Full text Link to item Cite