Kevin Maurice Coleman

Journal article Biochem Biophys Res Commun · October 8, 2004 The ability of steroid receptor RNA activator (SRA), an AF-1 coactivator, to contribute to differences in estrogen receptor (ER)-alpha and ERbeta transcriptional activity was tested. In transient transfections, SRA expression increased ERalpha- and ERbeta- ... Full text Link to item Cite

Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s).

Journal article J Biol Chem · April 11, 2003 Although increases in intracellular cAMP can stimulate estrogen receptor-alpha (ER alpha) activity in the absence of exogenous hormone, no studies have addressed whether ER beta can be similarly regulated. In transient transfections, forskolin plus 3-isobu ... Full text Link to item Cite

Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors.

Journal article Front Biosci · October 1, 2001 Recognition of the complexity of estrogen and estrogen receptor (ER) signaling has substantially increased in the last several years. In their genomic role, estrogens enter the cell and bind to ERs which are members of a superfamily of ligand-regulated tra ... Full text Link to item Cite

A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha.

Journal article Endocrinology · September 2001 It has previously been demonstrated that 19-nor contraceptive progestins undergo in vivo and in vitro enzyme-mediated A-ring double bond hydrogenation. Bioconversion of 19-nor progestins to their corresponding tetrahydro derivatives results in the loss of ... Full text Link to item Cite