Kevin Phillip Weinfurt

Journal article Psychooncology · June 2012 Featured Publication OBJECTIVE: We studied patients' experiences with oncology providers regarding communication about sexual issues during and after treatment for cancer. METHODS: During development of the Patient-Reported Outcomes Measurement Information System (PROMIS(®)) S ... Full text Link to item Cite

Relationships between changes in patient-reported health status and functional capacity in outpatients with heart failure.

Journal article Am Heart J · January 2012 Featured Publication BACKGROUND: Heart failure trials use a variety of measures of functional capacity and quality of life. Lack of formal assessments of the relationships between changes in multiple aspects of patient-reported health status and measures of functional capacity ... Full text Link to item Cite

Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research study.

Journal article J Med Syst · December 2011 Featured Publication New technologies may be required to integrate the National Institutes of Health's Patient Reported Outcome Management Information System (PROMIS) into multi-center clinical trials. To better understand this need, we identified likely PROMIS reporting forma ... Full text Link to item Cite

Sexual functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS®).

Journal article Psychooncology · April 2011 Featured Publication OBJECTIVE: Cancer and treatments for cancer affect specific aspects of sexual functioning and intimacy; however, limited qualitative work has been done in diverse cancer populations. As part of an effort to improve measurement of self-reported sexual funct ... Full text Link to item Cite

Developing a simplified consent form for biobanking.

Journal article PLoS One · October 8, 2010 Featured Publication BACKGROUND: Consent forms have lengthened over time and become harder for participants to understand. We sought to demonstrate the feasibility of creating a simplified consent form for biobanking that comprises the minimum information necessary to meet eth ... Full text Open Access Link to item Cite

Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)).

Journal article Psychooncology · October 2010 Featured Publication OBJECTIVE: Cancer and its treatments disturb sleep-wake functioning; however, there is little information available on the characteristics and consequences of sleep problems associated with cancer. As part of an effort to improve measurement of sleep-wake ... Full text Link to item Cite

Simplifying informed consent for biorepositories: stakeholder perspectives.

Journal article Genet Med · September 2010 Featured Publication PURPOSE: Complex and sometimes controversial information must be conveyed during the consent process for participation in biorepositories, and studies suggest that consent documents in general are growing in length and complexity. As a first step toward cr ... Full text Link to item Cite

The culture of faith and hope: patients' justifications for their high estimations of expected therapeutic benefit when enrolling in early phase oncology trials.

Journal article Cancer · August 1, 2010 Featured Publication BACKGROUND: Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity of informed consent. METHODS: The a ... Full text Link to item Cite

Oversight of financial conflicts of interest in commercially sponsored research in academic and nonacademic settings.

Journal article J Gen Intern Med · May 2010 Featured Publication BACKGROUND: Studies of conflicts of interest in clinical research have focused on academic centers, but most clinical research takes place in nonacademic settings. OBJECTIVE: To compare oversight and management of investigators' financial relationships in ... Full text Link to item Cite

Patient reactions to confidentiality, liability, and financial aspects of informed consent in cardiology research.

Journal article Circ Cardiovasc Qual Outcomes · March 2010 Featured Publication BACKGROUND: Although the informed consent process is supposed to help potential research participants make informed and voluntary decisions about participating in research, little is known about how participants react to language in the informed consent do ... Full text Link to item Cite

Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure.

Journal article Am Heart J · October 2009 Featured Publication BACKGROUND: Patient-reported outcomes are increasingly used to assess the efficacy of new treatments. Understanding relationships between these and clinical measures can facilitate their interpretation. We examined associations between patient-reported mea ... Full text Link to item Cite

Using cognitive interviews to evaluate items for measuring sexual functioning across cancer populations: improvements and remaining challenges.

Journal article Qual Life Res · October 2009 Featured Publication PURPOSE: One goal of the Patient-Reported Outcomes Measurement Information System (PROMIS) is to develop a measure of sexual functioning that broadens the definition of sexual activity and incorporates items that reflect constructs identified as important ... Full text Link to item Cite

Disclosure of financial relationships to participants in clinical research.

Journal article N Engl J Med · August 27, 2009 Featured Publication Full text Link to item Cite

Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.

Journal article JAMA · April 8, 2009 Featured Publication CONTEXT: Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. OBJECTIVE: To test the effects of exercise training on health status among patients with heart failure. DESIGN, SETTING, A ... Full text Link to item Cite

Initial report of the cancer Patient-Reported Outcomes Measurement Information System (PROMIS) sexual function committee: review of sexual function measures and domains used in oncology.

Journal article Cancer · March 15, 2009 Featured Publication For this report, the authors described the initial activities of the Cancer Patient-Reported Outcomes Measurement Information System (PROMIS)-Sexual Function domain group, which is part of the National Institutes of Health Roadmap Initiative to develop bri ... Full text Link to item Cite

Cancer patient preferences for quality and length of life.

Journal article Cancer · December 15, 2008 Featured Publication BACKGROUND: Optimal patient decision making requires integration of patient values, goals, and preferences with information received from the physician. In the case of a life-threatening illness such as cancer, the weights placed on quality of life (QOL) a ... Full text Link to item Cite

Improving health care efficiency and quality using tablet personal computers to collect research-quality, patient-reported data.

Journal article Health Serv Res · December 2008 Featured Publication OBJECTIVE: To determine whether e/Tablets (wireless tablet computers used in community oncology clinics to collect review of systems information at point of care) are feasible, acceptable, and valid for collecting research-quality data in academic oncology ... Full text Link to item Cite

Effects of disclosing financial interests on participation in medical research: a randomized vignette trial.

Journal article Am Heart J · October 2008 Featured Publication BACKGROUND: Little is known about the effects of investigators' financial disclosures on potential research participants. METHODS: We conducted a vignette trial in which 470 participants in a telephone survey were randomly assigned to receive a simulated i ... Full text Link to item Cite

Decisional conflict among patients who accept or decline participation in phase I oncology studies.

Journal article J Empir Res Hum Res Ethics · September 2008 Featured Publication WE COMPARED DECISIONAL CONFLICT among adults with advanced cancer who had accepted or declined participation in phase I cancer clinical trials. Respondents completed a 121-item questionnaire that included the Decisional Conflict Scale (DCS), which was desi ... Full text Link to item Cite

Effects of disclosing financial interests on attitudes toward clinical research.

Journal article J Gen Intern Med · June 2008 Featured Publication BACKGROUND: The effects of disclosing financial interests to potential research participants are not well understood. OBJECTIVE: To examine the effects of financial interest disclosures on potential research participants' attitudes toward clinical research ... Full text Link to item Cite

Consistency of financial interest disclosures in the biomedical literature: the case of coronary stents.

Journal article PLoS One · May 7, 2008 Featured Publication BACKGROUND: Disclosure of authors' financial interests has been proposed as a strategy for protecting the integrity of the biomedical literature. We examined whether authors' financial interests were disclosed consistently in articles on coronary stents pu ... Full text Open Access Link to item Cite

Expectations of benefit in early-phase clinical trials: implications for assessing the adequacy of informed consent.

Journal article Med Decis Making · 2008 Featured Publication BACKGROUND: Participants in early-phase clinical trials have reported high expectations of benefit from their participation. There is concern that participants misunderstand the trials to which they have consented, which is based on assumptions about what ... Full text Link to item Cite

Varieties of uncertainty and the validity of informed consent.

Journal article Clin Trials · 2008 Featured Publication Full text Link to item Cite

Using item banks to construct measures of patient reported outcomes in clinical trials: investigator perceptions.

Journal article Clin Trials · 2008 Featured Publication BACKGROUND: Item response theory (IRT) promises more sensitive and efficient measurement of patient-reported outcomes (PROs) than traditional approaches; however, the selection and use of PRO measures from IRT-based item banks differ from current methods o ... Full text Link to item Cite

Standardizing patient-reported outcomes assessment in cancer clinical trials: a patient-reported outcomes measurement information system initiative.

Journal article J Clin Oncol · November 10, 2007 Featured Publication Patient-reported outcomes (PROs), such as symptom scales or more broad-based health-related quality-of-life measures, play an important role in oncology clinical trials. They frequently are used to help evaluate cancer treatments, as well as for supportive ... Full text Link to item Cite

Documenting the rationale and psychometric characteristics of patient reported outcomes for labeling and promotional claims: the PRO Evidence Dossier.

Journal article Qual Life Res · May 2007 Featured Publication The Food and Drug Administration (FDA) and European Medicines Agency (EMEA) are willing to consider including information on patient reported outcomes (PROs) in product labeling and advertising. Pharmaceutical industry researchers must provide sufficient e ... Full text Link to item Cite

Value of high-cost cancer care: a behavioral science perspective.

Journal article J Clin Oncol · January 10, 2007 Featured Publication Concerns about the high costs of cancer care have led to a renewed interest in understanding how patients value the outcomes of care. Psychologists, economists, and others have highlighted some of the ways in which patients and caregivers perceive and make ... Full text Link to item Cite

Developing model language for disclosing financial interests to potential clinical research participants.

Journal article IRB · 2007 Featured Publication Link to item Cite

Use and perceptions of clinical practice guidelines by internal medicine physicians.

Journal article Am J Med Qual · 2007 Featured Publication The authors sought to explore the use and perceptions of clinical practice guidelines among internal medicine physicians. Through a Web-based survey, 201 board-certified internal medicine physicians rated their opinions on several statements using 7-point ... Full text Link to item Cite

Perspectives of clinical research coordinators on disclosing financial conflicts of interest to potential research participants.

Journal article Clin Trials · 2007 Featured Publication BACKGROUND: Disclosing financial interests to potential research participants during the informed consent process is one strategy for managing conflicts of interest. Given that clinical research coordinators are typically charged with administering the inf ... Full text Link to item Cite

Measuring trust in medical researchers.

Journal article Med Care · November 2006 Featured Publication BACKGROUND: Concern is widespread that the public's and participants' trust in medical research is threatened, but few empirical measures of research trust exist. This project aims to enable more rigorous study of researcher trust by developing and testing ... Full text Link to item Cite

Views of potential research participants on financial conflicts of interest: barriers and opportunities for effective disclosure.

Journal article J Gen Intern Med · September 2006 Featured Publication BACKGROUND: There is little guidance regarding how to disclose researchers' financial interests to potential research participants. OBJECTIVE: To determine what potential research participants want to know about financial interests, their capacity to under ... Full text Link to item Cite

Effect of zoledronic acid on pain associated with bone metastasis in patients with prostate cancer.

Journal article Ann Oncol · June 2006 Featured Publication BACKGROUND: Zoledronic acid reduces skeletal-related events associated with prostate cancer and has long-term efficacy in pain outcomes. Findings of treatment group differences in pain early in treatment are less reliable. We used a recently recommended an ... Full text Link to item Cite

Policies of academic medical centers for disclosing financial conflicts of interest to potential research participants.

Journal article Acad Med · February 2006 Featured Publication PURPOSE: To document the current state of institutional review board (IRB) and conflict of interest committee policies regarding disclosures of financial conflicts of interest to potential research participants, and to use this information to identify and ... Full text Link to item Cite

Disclosing conflicts of interest in clinical research: views of institutional review boards, conflict of interest committees, and investigators.

Journal article J Law Med Ethics · 2006 Featured Publication Strategies for disclosing investigators' financial interests to potential research participants have been adopted by many research institutions. However, little is known about how decisions are made regarding disclosures of financial interests to potential ... Full text Link to item Cite

The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer.

Journal article Ann Oncol · April 2005 Featured Publication BACKGROUND: We examined the clinical relevance of skeletal-related events (SREs) for health state preferences, pain and health-related quality of life in patients with advanced prostate cancer and a history of bone metastases. PATIENTS AND METHODS: Data we ... Full text Link to item Cite

Women's resources and use of strategies as risk and protective factors for reabuse over time.

Journal article Violence Against Women · March 2005 Featured Publication Using a longitudinal and ecological approach, we investigated the relationships between women's material and emotional resources and strategies and their ability to stay safe over time in a sample of 406 help-seeking African American women. The multivariat ... Full text Link to item Cite

Understanding of an aggregate probability statement by patients who are offered participation in Phase I clinical trials.

Journal article Cancer · January 1, 2005 Featured Publication BACKGROUND: There is concern that patients with poor numeracy may have difficulty understanding the information necessary to make informed treatment decisions. The authors sought to characterize a special form of numeracy among patients with advanced cance ... Full text Link to item Cite

Health-related quality of life among patients with breast cancer receiving zoledronic acid or pamidronate disodium for metastatic bone lesions.

Journal article Med Care · February 2004 Featured Publication BACKGROUND: Research on individual differences in health-related quality of life (HRQOL) can identify intervention targets and important covariates in analyses of treatment outcomes. OBJECTIVES: The objectives of this study were to describe HRQOL trajector ... Full text Link to item Cite

The correlation between patient characteristics and expectations of benefit from Phase I clinical trials.

Journal article Cancer · July 1, 2003 Featured Publication BACKGROUND: Patients in Phase I clinical trials sometimes report high expectations regarding the benefit of treatment. The authors examined a range of patient characteristics to determine which factors were associated with greater expectations of benefit f ... Full text Link to item Cite

Patient expectations of benefit from phase I clinical trials: linguistic considerations in diagnosing a therapeutic misconception.

Journal article Theor Med Bioeth · 2003 Featured Publication The ethical treatment of cancer patients participating in clinical trials requires that patients are well-informed about the potential benefits and risks associated with participation. When patients enrolled in phase I clinical trials report that their cha ... Full text Link to item Cite

Measuring agreement between patient and proxy responses to multidimensional health-related quality-of-life measures in clinical trials. An application of psychometric profile analysis.

Journal article J Clin Epidemiol · June 2002 Featured Publication When patients cannot provide responses to health-related quality-of-life (HRQOL) measures in clinical trials, family or friends may be asked to respond. We present a simple, comprehensive method for assessing agreement between patients with head injury and ... Full text Link to item Cite

Culture and social distance: a case study of methodological cautions.

Journal article J Soc Psychol · February 2001 Featured Publication The authors presented, as a case study of methodological challenges in cross-cultural research, E. S. Bogardus's (1925) Social Distance Scale, which requires respondents to indicate the social distance between themselves and others. The meaningfulness of t ... Full text Link to item Cite

Relationship between CD4 count, viral burden, and quality of life over time in HIV-1-infected patients.

Journal article Med Care · April 2000 Featured Publication BACKGROUND: Although surrogate markers such as CD4 counts and viral burden (HIV-1 RNA) are predictive of AIDS-related disease progression, little is known about the relationship between changes in surrogate markers and health-related quality of life (HRQOL ... Full text Link to item Cite

ACI-TIPI clinical trial. Acute cardiac ischemia time-insensitive predictive instrument.

Journal article Ann Intern Med · September 21, 1999 Featured Publication Full text Link to item Cite

Towards a composite scoring solution for the Neurobehavioral Functioning Inventory.

Journal article Qual Life Res · 1999 Featured Publication Little research has been conducted towards the development and evaluation of a measure of quality of life specific to head/brain injury populations. Accordingly, we examined responses to the Neurobehavioral Functioning Inventory in the context of a clinica ... Full text Link to item Cite

Contradictory subject response in longitudinal research.

Journal article J Stud Alcohol · May 1996 Featured Publication OBJECTIVE: This study investigated the prevalence of logical and estimation errors in a 4-year longitudinal survey of substance abuse for elementary and junior high school students. Logical errors occur when a subject reports having used a substance on one ... Full text Link to item Cite