Scholars@Duke
Kevin D. Welsher

Kevin D. Welsher

Robert R. & Katherine B. Penn Associate Professor
Chemistry
Box 90348, Durham, NC 27708
2213 French Science Center, Durham, NC 27705

Featured Works

Author Correction: Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA.

Journal article Nature communications · July 2020 Featured Publication An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Cite

Real-time 3D single molecule tracking.

Journal article Nature communications · July 2020 Featured Publication To date, single molecule studies have been reliant on tethering or confinement to achieve long duration and high temporal resolution measurements. Here, we present a 3D single-molecule active real-time tracking method (3D-SMART) which is capable of locking ... Full text Cite

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA.

Journal article Nature communications · February 2020 Featured Publication Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that incorporation of C-24 alkyl phytosterols into LNPs (eLNPs) enhances gene transfe ... Full text Cite