Scholars@Duke
Kim G Johnson

Kim G Johnson

Associate Professor of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
kim.g.johnson@duke.edu
932 Morreene Road, Durham, NC 27514
932 Morreene Road, Durham, NC 27514

Scholarly Works - Journal articles

Clinical Practice Outcomes With Lecanemab for Alzheimer Disease

Journal article Neurology Open Access · September 2026 Full text Cite

Projected effect of a high performing blood test on wait times for determination of Alzheimer's disease pathology in the United States.

Journal article J Alzheimers Dis · July 16, 2026 BackgroundBlood tests for Alzheimer's disease (AD) are emerging as alternative to amyloid positron emission tomography (PET) scans and analysis of cerebrospinal fluid (CSF). However, their effect on clinical decision-making and subsequent wait times in the ... Full text Link to item Cite

Evaluating the Duke Iterative Cognitive Examination Against the Montreal Cognitive Assessment: Validity and Clinical Utility.

Journal article Neurol Clin Pract · June 2026 BACKGROUND AND OBJECTIVES: Rapid and valid cognitive screening tools are a mainstay of clinical practice in the assessment of mild cognitive impairment and dementia. Although there are several available tools, there is concern for reduced sensitivity over ... Full text Link to item Cite

Cerebrospinal fluid amyloid-β 42/40 ratio is associated with ganglion cell-inner plexiform layer thinning in individuals with and without amyloid pathology.

Journal article J Alzheimers Dis · April 2026 BackgroundRetinal imaging offers a noninvasive window into neurodegenerative changes, yet its relationship with established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) remains poorly understood. This study addresses a critical gap by e ... Full text Link to item Cite

Comparison of Longitudinal Retinal and Choroidal Imaging Findings in Patients With Mild Cognitive Impairment and Cognitively Normal Control Participants

Journal article Journal of Vitreoretinal Diseases · January 1, 2026 Purpose: To compare longitudinal retinal and choroidal imaging findings in patients with mild cognitive impairment and cognitively normal control participants. Methods: Eyes of patients with mild cognitive impairment and cognitively normal controls were im ... Full text Cite

Recommended approaches to sharing individual research results in Alzheimer's disease research: A multidisciplinary expert Delphi consensus.

Journal article J Alzheimers Dis · November 2025 BackgroundAs criteria for diagnosing Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) evolves, AD-related biological measures of biomarkers (e.g., amyloid, tau) and genetic status (e.g., APOE) have gained heightened value in research ... Full text Link to item Cite

Sex Differences in Mortality and Health Care Utilization After Dementia Diagnosis.

Journal article JAMA Neurol · October 1, 2025 IMPORTANCE: Sex differences may contribute to disparities in dementia outcomes. OBJECTIVE: To understand the association between sex and mortality and health care services use after dementia diagnosis. DESIGN, SETTING, AND PARTICIPANTS: This nationwide coh ... Full text Link to item Cite

Implementation of an Alzheimer's Disease Blood Test: Adoption Experience by Memory Care Specialists in a Multi-Center Study.

Journal article J Pers Med · October 1, 2025 Background/Objectives: A high-performing blood biomarker (BBM) test for Alzheimer's disease (AD) represents an accurate, accessible, and scalable tool to aid healthcare professionals (HCPs) evaluating patients presenting with signs or symptoms of mild cogn ... Full text Link to item Cite

Estimation of the value-based price of a blood test for Alzheimer's disease pathology in primary and specialty care in the U.S.

Journal article J Prev Alzheimers Dis · August 2025 BACKGROUND: Blood tests for the pathology of Alzheimer's disease (AD) are emerging as alternative to amyloid PET scans and analysis of cerebrospinal fluid. (CSF). However, their economic value, which depends on test accuracy as well as effect on clinical d ... Full text Link to item Cite

Correlating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer's disease and amnestic mild cognitive impairment.

Journal article BMC Ophthalmol · July 1, 2025 BACKGROUND: We assess the relationships between retinal and choroidal structural and microvascular parameters and brain volumetric magnetic resonance imaging (MRI) parameters in individuals with amnestic mild cognitive impairment (aMCI) and Alzheimer's dis ... Full text Link to item Cite

Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.

Journal article Brain Struct Funct · March 19, 2025 Alzheimer's disease currently has no cure and is usually detected too late for interventions to be effective. In this study we have focused on cognitively normal subjects to study the impact of risk factors on their long-range brain connections. To detect ... Full text Link to item Cite

Genetic and biomarker disclosure process in a memory and aging study.

Journal article J Alzheimers Dis · March 2025 Despite growing awareness that disclosing biomarker results to research participants is aligned with ethical principles of researcher-participant partnership, there are currently no widely adopted guidelines for this disclosure in Alzheimer's disease resea ... Full text Link to item Cite

Neuropsychiatric Comorbidities and Psychotropic Medication Use in Medicare Beneficiaries With Dementia by Sex and Race.

Journal article J Geriatr Psychiatry Neurol · January 2025 BACKGROUND: Neuropsychiatric symptoms affect the majority of dementia patients. Past studies report high rates of potentially inappropriate prescribing of psychotropic medications in this population. We investigate differences in neuropsychiatric diagnoses ... Full text Link to item Cite

Racial Disparities in Low-Value Care in the Last Year of Life for Medicare Beneficiaries With Neurodegenerative Disease.

Journal article Neurol Clin Pract · April 2024 BACKGROUND AND OBJECTIVES: There are racial disparities in health care services received by patients with neurodegenerative diseases, but little is known about disparities in the last year of life, specifically in high-value and low-value care utilization. ... Full text Link to item Cite

Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer's disease.

Journal article Cereb Cortex · January 31, 2024 In addition to amyloid beta plaques and neurofibrillary tangles, Alzheimer's disease (AD) has been associated with elevated iron in deep gray matter nuclei using quantitative susceptibility mapping (QSM). However, only a few studies have examined cortical ... Full text Open Access Link to item Cite

Differences in Retinal and Choroidal Microvasculature and Structure in Dementia With Lewy Bodies Compared With Normal Cognition.

Journal article J Vitreoretin Dis · 2024 Purpose: To evaluate the retinal and choroidal microvasculature and structure in individuals with dementia with Lewy bodies (DLB) compared with controls with normal cognition using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: An ... Full text Open Access Link to item Cite

Clinician's perspectives on gene therapy for Alzheimer's disease: A qualitative study.

Journal article PLoS One · 2024 INTRODUCTION: We aimed to understand clinician views regarding gene therapy as a future treatment for Alzheimer's disease (AD) and potential barriers and facilitators to its use. METHODS: We interviewed ten clinicians who treat patients with AD. Clinicians ... Full text Open Access Link to item Cite

Angioarchitectural alterations in the retina and choroid in frontotemporal dementia.

Journal article PLoS One · 2024 OBJECTIVE: Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder that affects the frontal and temporal lobes of the brain, leading to cognitive decline and personality changes. The objective of this cross-sectional study was to characte ... Full text Open Access Link to item Cite

A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment.

Journal article Ann Clin Transl Neurol · October 2023 OBJECTIVE: The objective of this study was to examine clinicians' patient selection and result interpretation of a clinically validated mass spectrometry test measuring amyloid beta and ApoE blood biomarkers combined with patient age (PrecivityAD® blood te ... Full text Open Access Link to item Cite

Identifying vulnerable brain networks associated with Alzheimer's disease risk.

Journal article Cereb Cortex · April 25, 2023 The selective vulnerability of brain networks in individuals at risk for Alzheimer's disease (AD) may help differentiate pathological from normal aging at asymptomatic stages, allowing the implementation of more effective interventions. We used a sample of ... Full text Open Access Link to item Cite

Clozapine in the Geriatric Patient With Neuropsychiatric Comorbidities.

Journal article Prim Care Companion CNS Disord · October 20, 2022 Full text Link to item Cite

Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease.

Journal article Ophthalmol Sci · December 2021 PURPOSE: To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition. DESIGN: Cross-sectional. PARTICIPANTS: Patients with a clinical ... Full text Open Access Link to item Cite

Advances in Pharmacotherapy of Late-Life Depression.

Journal article Curr Psychiatry Rep · April 7, 2018 UNLABELLED: This paper reviews recent research on late-life depression (LLD) pharmacotherapy, focusing on updated information for monotherapy and augmentation treatments. We then review new research on moderators of clinical response and how to use the inf ... Full text Link to item Cite

Discharge Plans for Geriatric Inpatients with Delirium: A Plan to Stop Antipsychotics?

Journal article J Am Geriatr Soc · October 2017 BACKGROUND: Studies show inpatient geriatric patients with reversible conditions like delirium may continue on antipsychotic medications without clear indications after hospital discharge. We conducted this study to determine how often geriatric patients w ... Full text Link to item Cite

Re-emergence of Post-traumatic Stress Disorder Nightmares With Nursing Home Admission: Treatment With Prazosin

Journal article Journal of the American Medical Directors Association · February 1, 2013 Open Access Cite