Scholars@Duke
Kingshuk Roy Choudhury

Kingshuk Roy Choudhury

Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
kingshuk@duke.edu
Duke Box 2721, Durham, NC 27710
2424 Erwin Road Suite 302, 3063 Hock Plaza, Durham, NC 27705

Featured Works

Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.

Journal article Ir J Med Sci · December 2011 Featured Publication BACKGROUND: Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool. METHODS: We performed three experiments to elucidate ME ... Full text Link to item Cite

CT screening and follow-up of lung nodules: effects of tube current-time setting and nodule size and density on detectability and of tube current-time setting on apparent size.

Journal article AJR Am J Roentgenol · September 2011 Featured Publication OBJECTIVE: The purpose of the study was to quantify and compare the effect of CT dose and of size and density of nodules on the detectability of lung nodules and to quantify the influence of CT dose on the size of the nodules. MATERIALS AND METHODS: From 5 ... Full text Link to item Cite

Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models.

Journal article Stat Med · October 15, 2010 Featured Publication Xenograft trials allow tumor growth in human cell lines to be monitored over time in a mouse model. We consider the problem of inferring the effect of treatment combinations on tumor growth. A piecewise quadratic model with flexible phase change locations ... Full text Link to item Cite

Hypothesis testing for neural cell growth experiments using a hybrid branching process model.

Journal article Biostatistics · October 2010 Featured Publication Neuron branching patterns can characterize neural cell types and act as markers for neurodegenerative disease and neural development. We develop a hybrid Markovian model for neural branching that extends previously published models by (i) using a discretiz ... Full text Link to item Cite

Assessing operating characteristics of CAD algorithms in the absence of a gold standard.

Journal article Med Phys · April 2010 Featured Publication PURPOSE: The authors examine potential bias when using a reference reader panel as "gold standard" for estimating operating characteristics of CAD algorithms for detecting lesions. As an alternative, the authors propose latent class analysis (LCA), which d ... Full text Link to item Cite

A robust automated measure of average antibody staining in immunohistochemistry images.

Journal article J Histochem Cytochem · February 2010 Featured Publication Identifying and scoring cancer markers plays a key role in oncology, helping to characterize the tumor and predict the clinical course of the disease. The current method for scoring immunohistochemistry (IHC) slides is labor intensive and has inherent issu ... Full text Link to item Cite

Morphometric analysis for early detection of changes in cellular structure in a toxicological experiment.

Journal article Stat Med · December 20, 2007 Featured Publication This paper presents a method for semi-automatic analysis of morphometry in image cytometry studies. We examine morphological changes in neuroblastoma cells caused by a toxin. Nuclei are automatically recognized from images using a constrained seeded region ... Full text Link to item Cite

Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis.

Journal article Eur J Nucl Med Mol Imaging · September 2002 Featured Publication In a retrospective analysis of patients with sarcoma who underwent fluorodeoxyglucose positron emission tomography (FDG PET) imaging, tumor maximum FDG uptake was analyzed for ability to predict patient survival and disease-free interval. Two hundred and n ... Full text Link to item Cite

Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study.

Journal article Hepatology · January 2000 Featured Publication The aim of this study was to determine the variation in hepatitis C viral load over an extended period of patient follow up. Serum samples were collected from 49 female individuals who were identified as having been infected from the same source of hepatit ... Full text Link to item Cite