Kishan S Parikh | Scholars@Duke

Kishan S Parikh
Assistant Professor of Medicine

Duke University Medical Center
Duke Clinical Research Institute

Current Research Interests

Pulmonary Hypertension
Heart Failure with Preserved Ejection Fraction
Heart Failure with Reduced Ejection Fraction
Precision Pharmacotherapy
Mobile Health

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2018
Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2018

Contact Information

2400 Pratt St, Rm 0311 Terrace Level, Durham, NC 27705
P.O. Box 17969, 2400 Pratt St, Rm 0311 Terrace Level, Durham, NC 27705
kishan.parikh@duke.edu (919) 668-8820

Background
Education, Training, & Certifications
- Advanced Heart Failure, Mechanical Circulatory Support and Transplant Fellowship, Medicine, Duke University School of Medicine 2017 - 2018
- Cardiovascular Disease Fellowship, Medicine, Duke University School of Medicine 2013 - 2017
- Chief Resident, Medicine, University of Chicago 2012 - 2013
- Internal Medicine Residency, Medicine, University of Chicago 2009 - 2012
- M.D., Northwestern University Feinberg School of Medicine 2009
Medical Licensure
- 2013-00285. North Carolina. 2013
Leadership & Clinical Positions at Duke
- Director of Pulmonary Hypertension in Wake County
Research
Selected Grants
- REDUCE LAP-HF 2018 - 2026
- SPIRRIT - HFpEF awarded by National Institutes of Health 2018 - 2022
- PAH trial of GB002 2019 - 2020
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Shelburne, Nicholas J., Kishan S. Parikh, Karen Chiswell, Linda K. Shaw, Joseph Sivak, Kristine Arges, Jennifer Tomfohr, et al. “Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension..” Am J Cardiol, July 29, 2019. https://doi.org/10.1016/j.amjcard.2019.07.026.
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  - Benza, Raymond L., Mark Doyle, David Lasorda, Kishan S. Parikh, Priscilla Correa-Jaque, Nima Badie, Greg Ginn, et al. “Monitoring Pulmonary Arterial Hypertension Using an Implantable Hemodynamic Sensor..” Chest, June 29, 2019. https://doi.org/10.1016/j.chest.2019.06.010.
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  - Awerbach, Jordan D., Kathryn A. Stackhouse, Joanne Lee, Talal Dahhan, Kishan S. Parikh, and Richard A. Krasuski. “Outcomes of lung disease-associated pulmonary hypertension and impact of elevated pulmonary vascular resistance..” Respir Med 150 (April 2019): 126–30. https://doi.org/10.1016/j.rmed.2019.03.004.
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  - Parikh, Kishan S., Talal Dahhan, Leigh Nicholl, Nicole Ruopp, Gina-Maria Pomann, Terry Fortin, Victor F. Tapson, and Sudarshan Rajagopal. “Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension..” Sci Rep 9, no. 1 (March 11, 2019). https://doi.org/10.1038/s41598-019-40030-w.
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  - Parikh, Kishan S., Shubin Sheng, Bradley G. Hammill, Clyde W. Yancy, Gregg C. Fonarow, Adrian F. Hernandez, and Adam D. DeVore. “Characteristics of Acute Heart Failure Hospitalizations Based on Presenting Severity..” Circ Heart Fail 12, no. 1 (January 2019). https://doi.org/10.1161/CIRCHEARTFAILURE.118.005171.
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  - Fudim, Marat, Kishan S. Parikh, Allison Dunning, Adam D. DeVore, Robert J. Mentz, Phillip J. Schulte, Paul W. Armstrong, et al. “Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF)..” Am J Cardiol 122, no. 9 (November 1, 2018): 1506–12. https://doi.org/10.1016/j.amjcard.2018.07.023.
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  - Parikh, Kishan S., Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, et al. “Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials..” Jacc Heart Fail 6, no. 8 (August 2018): 619–32. https://doi.org/10.1016/j.jchf.2018.06.008.
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  - Parikh, Kishan S., Mona Fiuzat, Gordon Davis, Megan Neely, Penny Blain-Nelson, David J. Whellan, William T. Abraham, et al. “Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes..” Circ Genom Precis Med 11, no. 8 (August 2018). https://doi.org/10.1161/CIRCGEN.117.002210.
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  - Laffin, Luke J., Amit V. Patel, Narayan Saha, Julian Barbat, James K. Hall, Matthew Cain, Kishan Parikh, Jay Shah, and Kirk T. Spencer. “Focused cardiac ultrasound as a predictor of readmission in acute decompensated heart failure..” Int J Cardiovasc Imaging 34, no. 7 (July 2018): 1075–79. https://doi.org/10.1007/s10554-018-1317-1.
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  - Patel, Chetan B., and Kishan S. Parikh. “Cardiac Rehabilitation After Ventricular Assist Device Implantation: A Worthwhile Exercise?.” Jacc Heart Fail 6, no. 2 (February 2018): 140–42. https://doi.org/10.1016/j.jchf.2017.12.009.
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  - Vemulapalli, Sreekanth, Kishan Parikh, Remy Coeytaux, Victor Hasselblad, Amanda McBroom, Abigail Johnston, Giselle Raitz, et al. “Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins..” Am Heart J 196 (February 2018): 131–43. https://doi.org/10.1016/j.ahj.2017.09.017.
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  - Parikh, Kishan S., Michael P. Gray, Lewis J. Rubin, David Badesch, and Richard A. Krasuski. “Overdue to understand anticoagulation in pulmonary arterial hypertension..” Pulm Circ 8, no. 1 (January 2018). https://doi.org/10.1177/2045893217743184.
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  - Parikh, Kishan S., and Jonathan P. Piccini. “Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure..” Curr Heart Fail Rep 14, no. 6 (December 2017): 529–35. https://doi.org/10.1007/s11897-017-0364-6.
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  - Parikh, Kishan S., Melissa A. Greiner, Wei Wang, Yuan-I Min, Adolfo Correa, Benjamin F. Banahan, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries..” Epidemiology 28, no. 5 (September 2017): 740–46. https://doi.org/10.1097/EDE.0000000000000689.
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  - Parikh, Kishan S., Kathryn A. Stackhouse, Stephen A. Hart, Thomas M. Bashore, and Richard A. Krasuski. “Health insurance and racial disparities in pulmonary hypertension outcomes..” Am J Manag Care 23, no. 8 (August 2017): 474–80.
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  - Parikh, Kishan S., Steven J. Lippmann, Melissa Greiner, Paul A. Heidenreich, Clyde W. Yancy, Gregg C. Fonarow, and Adrian F. Hernandez. “Scope of Sacubitril/Valsartan Eligibility After Heart Failure Hospitalization: Findings From the GWTG-HF Registry (Get With The Guidelines-Heart Failure)..” Circulation 135, no. 21 (May 23, 2017): 2077–80. https://doi.org/10.1161/CIRCULATIONAHA.117.027773.
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  - Luo, Nancy, Peter Merrill, Kishan S. Parikh, David J. Whellan, Ileana L. Piña, Mona Fiuzat, William E. Kraus, et al. “Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation..” J Am Coll Cardiol 69, no. 13 (April 4, 2017): 1683–91. https://doi.org/10.1016/j.jacc.2017.01.032.
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  - Parikh, Kishan S., Youlan Rao, Tariq Ahmad, Kai Shen, G Michael Felker, and Sudarshan Rajagopal. “Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis..” Pulm Circ 7, no. 2 (April 2017): 486–93. https://doi.org/10.1177/2045893217705891.
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  - Parikh, Kishan S., Melissa A. Greiner, Takeki Suzuki, Adam D. DeVore, Chad Blackshear, Joseph F. Maher, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study..” Jama Cardiol 2, no. 2 (February 1, 2017): 172–80. https://doi.org/10.1001/jamacardio.2016.3234.
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  - Parikh, Kishan S., Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, Ileana L. Piña, et al. “Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION)..” Am J Cardiol 118, no. 8 (October 15, 2016): 1211–16. https://doi.org/10.1016/j.amjcard.2016.07.040.
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  - Krishnamurthy, Yamini, Lauren B. Cooper, Kishan S. Parikh, G Michael Felker, Carmelo A. Milano, Joseph G. Rogers, Adrian F. Hernandez, and Chetan B. Patel. “Pulmonary Hypertension in the Era of Mechanical Circulatory Support..” Asaio J 62, no. 5 (September 2016): 505–12. https://doi.org/10.1097/MAT.0000000000000408.
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  - Sharma, Abhinav, Kishan S. Parikh, and Christopher B. Fordyce. “Active Engagement: A Fellow's Guide to Academic Conferences..” J Am Coll Cardiol 67, no. 19 (May 17, 2016): 2306–9. https://doi.org/10.1016/j.jacc.2016.03.503.
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  - Czobor, Peter, Joseph M. Venturini, Kishan S. Parikh, Elizabeth M. Retzer, Janet Friant, Valluvan Jeevanandam, Mark J. Russo, et al. “Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Patients Treated With Percutaneous Veno-Arterial Extracorporeal Membrane Oxygenation..” J Invasive Cardiol 28, no. 4 (April 2016): 133–38.
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  - Parikh, Kishan S., Sudarshan Rajagopal, Terry Fortin, Victor F. Tapson, and Abby D. Poms. “Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension..” J Cardiovasc Pharmacol 67, no. 4 (April 2016): 322–25. https://doi.org/10.1097/FJC.0000000000000357.
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  - Zietlow, Kahli, Taylor C. Bazemore, and Kishan S. Parikh. “Diagnosing pulmonic valve infective endocarditis with positron emission tomography-CT..” Bmj Case Rep 2016 (February 1, 2016). https://doi.org/10.1136/bcr-2015-213491.
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  - Parikh, Kishan S., G Michael Felker, and Marco Metra. “Mode of Death After Acute Heart Failure Hospitalization　- A Clue to Possible Mechanisms..” Circ J 80, no. 1 (2016): 17–23. https://doi.org/10.1253/circj.CJ-15-1006.
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  - Parikh, Kishan S., Sudarshan Rajagopal, Kristine Arges, Tariq Ahmad, Joseph Sivak, Prashant Kaul, Svati H. Shah, et al. “Use of outcome measures in pulmonary hypertension clinical trials..” Am Heart J 170, no. 3 (September 2015): 419-29.e3. https://doi.org/10.1016/j.ahj.2015.06.010.
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  - Parikh, Kishan S., Tariq Ahmad, and Mona Fiuzat. “Potential applications of pharmacogenomics to heart failure therapies..” Heart Fail Clin 10, no. 4 (October 2014): 599–606. https://doi.org/10.1016/j.hfc.2014.07.007.
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  - Piao, Lin, Yong-Hu Fang, Kishan Parikh, John J. Ryan, Peter T. Toth, and Stephen L. Archer. “Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension..” J Mol Med (Berl) 91, no. 10 (October 2013): 1185–97. https://doi.org/10.1007/s00109-013-1064-7.
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  - Piao, Lin, Vaninder K. Sidhu, Yong-Hu Fang, John J. Ryan, Kishan S. Parikh, Zhigang Hong, Peter T. Toth, et al. “FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate..” J Mol Med (Berl) 91, no. 3 (March 2013): 333–46. https://doi.org/10.1007/s00109-012-0982-0.
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  - Parikh, Kishan S., Amit K. Mehrotra, Mark J. Russo, Roberto M. Lang, Allen Anderson, Valluvan Jeevanandam, Benjamin H. Freed, et al. “Percutaneous transcatheter aortic valve closure successfully treats left ventricular assist device-associated aortic insufficiency and improves cardiac hemodynamics..” Jacc Cardiovasc Interv 6, no. 1 (January 2013): 84–89. https://doi.org/10.1016/j.jcin.2012.08.021.
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  - Piao, Lin, Yong-Hu Fang, Kishan S. Parikh, John J. Ryan, Karen M. D’Souza, Tiju Theccanat, Peter T. Toth, et al. “GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension..” Circulation 126, no. 24 (December 11, 2012): 2859–69. https://doi.org/10.1161/CIRCULATIONAHA.112.109868.
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  - Parikh, Kishan S., Rajiv Agarwal, Amit K. Mehrotra, and Rajiv S. Swamy. “Wellens syndrome: a life-saving diagnosis..” Am J Emerg Med 30, no. 1 (January 2012): 255.e3-255.e5. https://doi.org/10.1016/j.ajem.2010.10.014.
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  - Patel, Ravi B., Jason Ng, Vikram Reddy, Moulin Chokshi, Kishan Parikh, Haris Subacius, Alawi A. Alsheikh-Ali, et al. “Early repolarization associated with ventricular arrhythmias in patients with chronic coronary artery disease..” Circ Arrhythm Electrophysiol 3, no. 5 (October 2010): 489–95. https://doi.org/10.1161/CIRCEP.109.921130.
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  - Somiari, Stella B., Craig D. Shriver, Jing He, Kishan Parikh, Rick Jordan, Jeffrey Hooke, Hai Hu, et al. “Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization..” Cancer Genet Cytogenet 155, no. 2 (December 2004): 108–18. https://doi.org/10.1016/j.cancergencyto.2004.02.023.
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- Conference Papers
  - Awerbach, Jordan, Kathryn A. Stackhouse, Joanne Lee, Kishan Parikh, Mouhammad Fathallah, and Richard Krasuski. “OUTCOME OF LUNG DISEASE-RELATED PULMONARY HYPERTENSION AND IMPACT OF VASOREACTIVITY.” In Journal of the American College of Cardiology, 71:A1954–A1954. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)32495-1.
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  - Bazemore, Taylor, Kahli Zietlow, and Kishan Parikh. “DIAGNOSIS OF PULMONIC VALVE INFECTIVE ENDOCARDITIS WITH THE USE OF POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY SCAN.” In Journal of the American College of Cardiology, 67:1031–1031. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)31032-4.
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  - Parikh, K. S., Y. Rao, K. Shen, and S. Rajagopal. “Patient Characteristic Cluster Analysis Predicts Response To Therapy To Oral Treprostinil In Pulmonary Arterial Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Swaminathan, A. C., A. Poms, K. Kennedy, H. Zhu, E. Gaspard, T. A. Fortin, J. Senick, et al. “Toward Theranostic Biomarkers In Pulmonary Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Mentz, Robert J., Kishan Parikh, Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, et al. “Implications of Angina Pectoris on Quality of Life, Functional Capacity and Clinical Outcomes in Chronic Heart Failure Patients: Insights From HF-ACTION.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Parikh, Kishan S., Mona Fiuzat, Megan Neely, Tariq Ahmad, G Michael Felker, Ileana Pina, Kirkwood Adams, et al. “ADRENERGIC RECEPTOR POLYMORPHISMS INTERACT WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES ESPECIALLY IN BLACK RACE: RESULTS FROM HF-ACTION DNA SUBSTUDY.” In Journal of the American College of Cardiology, 65:A794–A794. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)60794-x.
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  - Parikh, Kishan S., Mona Fiuzat, Megan Neely, Tariq Ahmad, G Michael Felker, Ileana Pina, Kirkwood Adams, et al. “ALPHA-2C ADRENERGIC RECEPTOR POLYMORPHISM INTERACTS WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES DIFFERENTLY IN BLACK RACE: RESULTS FROM THE HF-ACTION DNA SUBSTUDY.” In Journal of the American College of Cardiology, 65:A964–A964. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)60964-0.
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  - Laffin, Luke J., Amit Patel, Narayan Saha, Julian Barbat, James K. Hall, Matthew Cain, Kishan Parikh, Jay Shah, and Kirk Spencer. “INFERIOR VENA CAVA MEASUREMENT BY FOCUSED CARDIAC ULTRASOUND IN ACUTE DECOMPENSATED HEART FAILURE PREVENTS HOSPITAL READMISSIONS.” In Journal of the American College of Cardiology, 63:A542–A542. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)60542-8.
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  - Czobor, Peter, Kishan Parikh, Sandeep Nathan, Janet Karol, and Atman P. Shah. “Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Venoarterial Extracorporeal Membrane Oxygenation.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Piao, Lin, Yong-Hu Fang, Kishan Parikh, Peter T. Toth, Glenn Marsboom, and Stephen L. Archer. “A First Description of Increased Glutaminolysis in Experimental Right Ventricular Hypertrophy; Association With Ischemia-Induced Activation of cMyc.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Parikh, Kishan, Eugene Greenstein, Jason Ng, Haris Subacius, and Alan Kadish. “J Point ST Elevation Does Not Predict Arrhythmic Events in Dilated Cardiomyopathy.” In Journal of the American College of Cardiology, 53:A120–21. ELSEVIER SCIENCE INC, 2009.
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Scholarly, Clinical, & Service Activities
Clinical Activities
- Pulmonary Vascular Disease Center
  Advanced Heart Failure and Cardiac Transplantation Program
  Wake County Pulmonary Hypertension and Dyspnea Clinic

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Education, Training, & Certifications

Medical Licensure

Leadership & Clinical Positions at Duke

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Clinical Activities