Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Advanced Heart Failure, Mechanical Circulatory Support and Transplant Fellowship, Medicine, Duke University School of Medicine 2017 - 2018
  • Cardiovascular Disease Fellowship, Medicine, Duke University School of Medicine 2013 - 2017
  • Chief Resident, Medicine, The University of Chicago 2012 - 2013
  • Internal Medicine Residency, Medicine, The University of Chicago 2009 - 2012
  • M.D., Northwestern University, Feinberg School of Medicine 2009
• 

  Medical Licensure

  • 2013-00285. North Carolina. 2013
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2018 - 2020
• 

  Leadership & Clinical Positions at Duke

  • Director of Pulmonary Hypertension in Wake County
• Research
• 

  Selected Grants

  • REDUCE LAP-HF awarded by Corvia Medical, Inc. 2018 - 2026
  • A Multicenter, Randomized, Double-blind, Placebo-controlled Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag SPHINX awarded by Janssen Research & Development, LLC 2021 - 2025
  • Complexa Prime Open Label extention awarded by Complexa, Inc 2020 - 2025
  • Pulmonary Hypertension Databank and Electronic Health Record Analysis awarded by Clinetic, Inc 2021 - 2023
  • Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction awarded by National Institutes of Health 2018 - 2022
  • Multicenter Exercise Tolerance Evaluation of Omecamtiv Mecarbil Related to Increased Contractility in Heart Failure awarded by Cytokinetics, Inc. 2019 - 2021
  • PAH trial of GB002 awarded by Gossamer Bio 2019 - 2021
  • Complexa PRIME - CXA-10-301 awarded by Complexa, Inc 2018 - 2020
  • Retrospective and prospective international EKoSoNic® registry Of the treatment and Clinical OUTcomes of patients with Pulmonary Embolism awarded by BTG International Inc 2018 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lekavich, Carolyn L., Dennis Abraham, Marat Fudim, Cynthia Green, Robert J. Mentz, Karol Harshaw-Ellis, Margaret Bowers, et al. “Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.” J Card Fail, May 7, 2021. https://doi.org/10.1016/j.cardfail.2021.03.013.
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    • Swaminathan, Aparna C., Hongmei Zhu, Victor Tapson, Yuliya Lokhnygina, Abby Poms, Zach Kelleher, Elijah Gaspard, et al. “Treatment-related biomarkers in pulmonary hypertension patients on oral therapies.” Respir Res 21, no. 1 (November 19, 2020): 304. https://doi.org/10.1186/s12931-020-01566-y.
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    • Egolum, Ugochukwu O., Kishan Parikh, Carolyn Lekavich, Jedrek Wosik, Camille Frazier-Mills, and Marat Fudim. “Applications of the Multisensor HeartLogic Heart Failure Monitoring Algorithm During the COVID-19 Global Pandemic.” Jacc Case Rep 2, no. 14 (November 18, 2020): 2265–69. https://doi.org/10.1016/j.jaccas.2020.09.035.
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    • DesJardin, Jacqueline T., Nicholas A. Kolaitis, Noah Kime, Richard A. Kronmal, Raymond L. Benza, Jean M. Elwing, Matthew R. Lammi, et al. “Age-related differences in hemodynamics and functional status in pulmonary arterial hypertension: Baseline results from the Pulmonary Hypertension Association Registry.” J Heart Lung Transplant 39, no. 9 (September 2020): 945–53. https://doi.org/10.1016/j.healun.2020.05.005.
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    • Edmonston, Daniel L., Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis Abraham, Alexander Grabner, Matthew A. Sparks, and Myles Wolf. “Pulmonary Hypertension Subtypes and Mortality in CKD.” Am J Kidney Dis 75, no. 5 (May 2020): 713–24. https://doi.org/10.1053/j.ajkd.2019.08.027.
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    • Parikh, Kishan S., Sean Doerfler, Nicholas Shelburne, Karla Kennedy, Jordan Whitson, Talal Dahhan, Terry Fortin, and Sudarshan Rajagopal. “Experience in Transitioning From Parenteral Prostacyclins to Selexipag in Pulmonary Arterial Hypertension.” J Cardiovasc Pharmacol 75, no. 4 (April 2020): 299–304. https://doi.org/10.1097/FJC.0000000000000800.
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    • Benza, Raymond L., Mark Doyle, David Lasorda, Kishan S. Parikh, Priscilla Correa-Jaque, Nima Badie, Greg Ginn, et al. “Monitoring Pulmonary Arterial Hypertension Using an Implantable Hemodynamic Sensor.” Chest 156, no. 6 (December 2019): 1176–86. https://doi.org/10.1016/j.chest.2019.06.010.
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    • Regan, Jessica A., Dalane W. Kitzman, Eric S. Leifer, William E. Kraus, Jerome L. Fleg, Daniel E. Forman, David J. Whellan, et al. “Impact of Age on Comorbidities and Outcomes in Heart Failure With Reduced Ejection Fraction.” Jacc Heart Fail 7, no. 12 (December 2019): 1056–65. https://doi.org/10.1016/j.jchf.2019.09.004.
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    • Wang, Ziyi, Elianna A. Bier, Aparna Swaminathan, Kishan Parikh, John Nouls, Mu He, Joseph G. Mammarappallil, Sheng Luo, Bastiaan Driehuys, and Sudarshan Rajagopal. “Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.” Eur Respir J 54, no. 6 (December 2019). https://doi.org/10.1183/13993003.00831-2019.
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    • Shelburne, Nicholas J., Kishan S. Parikh, Karen Chiswell, Linda K. Shaw, Joseph Sivak, Kristine Arges, Jennifer Tomfohr, et al. “Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension.” Am J Cardiol 124, no. 8 (October 15, 2019): 1298–1304. https://doi.org/10.1016/j.amjcard.2019.07.026.
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    • Awerbach, Jordan D., Kathryn A. Stackhouse, Joanne Lee, Talal Dahhan, Kishan S. Parikh, and Richard A. Krasuski. “Outcomes of lung disease-associated pulmonary hypertension and impact of elevated pulmonary vascular resistance.” Respir Med 150 (April 2019): 126–30. https://doi.org/10.1016/j.rmed.2019.03.004.
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    • Parikh, Kishan S., Talal Dahhan, Leigh Nicholl, Nicole Ruopp, Gina-Maria Pomann, Terry Fortin, Victor F. Tapson, and Sudarshan Rajagopal. “Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension.” Sci Rep 9, no. 1 (March 11, 2019): 4061. https://doi.org/10.1038/s41598-019-40030-w.
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    • Parikh, Kishan S., Shubin Sheng, Bradley G. Hammill, Clyde W. Yancy, Gregg C. Fonarow, Adrian F. Hernandez, and Adam D. DeVore. “Characteristics of Acute Heart Failure Hospitalizations Based on Presenting Severity.” Circ Heart Fail 12, no. 1 (January 2019): e005171. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005171.
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    • Fudim, Marat, Kishan S. Parikh, Allison Dunning, Adam D. DeVore, Robert J. Mentz, Phillip J. Schulte, Paul W. Armstrong, et al. “Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF).” Am J Cardiol 122, no. 9 (November 1, 2018): 1506–12. https://doi.org/10.1016/j.amjcard.2018.07.023.
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    • Parikh, Kishan S., Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, et al. “Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials.” Jacc Heart Fail 6, no. 8 (August 2018): 619–32. https://doi.org/10.1016/j.jchf.2018.06.008.
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    • Parikh, Kishan S., Mona Fiuzat, Gordon Davis, Megan Neely, Penny Blain-Nelson, David J. Whellan, William T. Abraham, et al. “Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.” Circ Genom Precis Med 11, no. 8 (August 2018): e002210. https://doi.org/10.1161/CIRCGEN.117.002210.
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    • Patel, Chetan B., and Kishan S. Parikh. “Cardiac Rehabilitation After Ventricular Assist Device Implantation: A Worthwhile Exercise?” Jacc Heart Fail 6, no. 2 (February 2018): 140–42. https://doi.org/10.1016/j.jchf.2017.12.009.
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    • Vemulapalli, Sreekanth, Kishan Parikh, Remy Coeytaux, Victor Hasselblad, Amanda McBroom, Abigail Johnston, Giselle Raitz, et al. “Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins.” Am Heart J 196 (February 2018): 131–43. https://doi.org/10.1016/j.ahj.2017.09.017.
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    • Parikh, Kishan S., Michael P. Gray, Lewis J. Rubin, David Badesch, and Richard A. Krasuski. “Overdue to understand anticoagulation in pulmonary arterial hypertension.” Pulm Circ 8, no. 1 (January 2018): 2045893217743184. https://doi.org/10.1177/2045893217743184.
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    • Parikh, Kishan S., and Jonathan P. Piccini. “Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure.” Curr Heart Fail Rep 14, no. 6 (December 2017): 529–35. https://doi.org/10.1007/s11897-017-0364-6.
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    • Parikh, Kishan S., Melissa A. Greiner, Wei Wang, Yuan-I Min, Adolfo Correa, Benjamin F. Banahan, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries.” Epidemiology 28, no. 5 (September 2017): 740–46. https://doi.org/10.1097/EDE.0000000000000689.
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    • Parikh, Kishan S., Kathryn A. Stackhouse, Stephen A. Hart, Thomas M. Bashore, and Richard A. Krasuski. “Health insurance and racial disparities in pulmonary hypertension outcomes.” Am J Manag Care 23, no. 8 (August 2017): 474–80.
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    • Parikh, Kishan S., Steven J. Lippmann, Melissa Greiner, Paul A. Heidenreich, Clyde W. Yancy, Gregg C. Fonarow, and Adrian F. Hernandez. “Scope of Sacubitril/Valsartan Eligibility After Heart Failure Hospitalization: Findings From the GWTG-HF Registry (Get With The Guidelines-Heart Failure).” Circulation 135, no. 21 (May 23, 2017): 2077–80. https://doi.org/10.1161/CIRCULATIONAHA.117.027773.
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    • Luo, Nancy, Peter Merrill, Kishan S. Parikh, David J. Whellan, Ileana L. Piña, Mona Fiuzat, William E. Kraus, et al. “Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.” J Am Coll Cardiol 69, no. 13 (April 4, 2017): 1683–91. https://doi.org/10.1016/j.jacc.2017.01.032.
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    • Parikh, Kishan S., Youlan Rao, Tariq Ahmad, Kai Shen, G Michael Felker, and Sudarshan Rajagopal. “Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis.” Pulm Circ 7, no. 2 (April 2017): 486–93. https://doi.org/10.1177/2045893217705891.
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    • Parikh, Kishan S., Melissa A. Greiner, Takeki Suzuki, Adam D. DeVore, Chad Blackshear, Joseph F. Maher, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study.” Jama Cardiol 2, no. 2 (February 1, 2017): 172–80. https://doi.org/10.1001/jamacardio.2016.3234.
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    • Parikh, Kishan S., Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, Ileana L. Piña, et al. “Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).” Am J Cardiol 118, no. 8 (October 15, 2016): 1211–16. https://doi.org/10.1016/j.amjcard.2016.07.040.
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    • Krishnamurthy, Yamini, Lauren B. Cooper, Kishan S. Parikh, G Michael Felker, Carmelo A. Milano, Joseph G. Rogers, Adrian F. Hernandez, and Chetan B. Patel. “Pulmonary Hypertension in the Era of Mechanical Circulatory Support.” Asaio J 62, no. 5 (September 2016): 505–12. https://doi.org/10.1097/MAT.0000000000000408.
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    • Sharma, Abhinav, Kishan S. Parikh, and Christopher B. Fordyce. “Active Engagement: A Fellow's Guide to Academic Conferences.” J Am Coll Cardiol 67, no. 19 (May 17, 2016): 2306–9. https://doi.org/10.1016/j.jacc.2016.03.503.
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    • Czobor, Peter, Joseph M. Venturini, Kishan S. Parikh, Elizabeth M. Retzer, Janet Friant, Valluvan Jeevanandam, Mark J. Russo, et al. “Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Patients Treated With Percutaneous Veno-Arterial Extracorporeal Membrane Oxygenation.” J Invasive Cardiol 28, no. 4 (April 2016): 133–38.
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    • Parikh, Kishan S., Sudarshan Rajagopal, Terry Fortin, Victor F. Tapson, and Abby D. Poms. “Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension.” J Cardiovasc Pharmacol 67, no. 4 (April 2016): 322–25. https://doi.org/10.1097/FJC.0000000000000357.
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    • Zietlow, Kahli, Taylor C. Bazemore, and Kishan S. Parikh. “Diagnosing pulmonic valve infective endocarditis with positron emission tomography-CT.” Bmj Case Rep 2016 (February 1, 2016). https://doi.org/10.1136/bcr-2015-213491.
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    • Parikh, Kishan S., G Michael Felker, and Marco Metra. “Mode of Death After Acute Heart Failure Hospitalization　- A Clue to Possible Mechanisms.” Circ J 80, no. 1 (2016): 17–23. https://doi.org/10.1253/circj.CJ-15-1006.
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    • Parikh, Kishan S., Sudarshan Rajagopal, Kristine Arges, Tariq Ahmad, Joseph Sivak, Prashant Kaul, Svati H. Shah, et al. “Use of outcome measures in pulmonary hypertension clinical trials.” Am Heart J 170, no. 3 (September 2015): 419-29.e3. https://doi.org/10.1016/j.ahj.2015.06.010.
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    • Parikh, Kishan S., Tariq Ahmad, and Mona Fiuzat. “Potential applications of pharmacogenomics to heart failure therapies.” Heart Fail Clin 10, no. 4 (October 2014): 599–606. https://doi.org/10.1016/j.hfc.2014.07.007.
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    • Piao, Lin, Yong-Hu Fang, Kishan Parikh, John J. Ryan, Peter T. Toth, and Stephen L. Archer. “Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension.” J Mol Med (Berl) 91, no. 10 (October 2013): 1185–97. https://doi.org/10.1007/s00109-013-1064-7.
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    • Piao, Lin, Vaninder K. Sidhu, Yong-Hu Fang, John J. Ryan, Kishan S. Parikh, Zhigang Hong, Peter T. Toth, et al. “FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.” J Mol Med (Berl) 91, no. 3 (March 2013): 333–46. https://doi.org/10.1007/s00109-012-0982-0.
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    • Parikh, Kishan S., Amit K. Mehrotra, Mark J. Russo, Roberto M. Lang, Allen Anderson, Valluvan Jeevanandam, Benjamin H. Freed, et al. “Percutaneous transcatheter aortic valve closure successfully treats left ventricular assist device-associated aortic insufficiency and improves cardiac hemodynamics.” Jacc Cardiovasc Interv 6, no. 1 (January 2013): 84–89. https://doi.org/10.1016/j.jcin.2012.08.021.
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    • Piao, Lin, Yong-Hu Fang, Kishan S. Parikh, John J. Ryan, Karen M. D’Souza, Tiju Theccanat, Peter T. Toth, et al. “GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.” Circulation 126, no. 24 (December 11, 2012): 2859–69. https://doi.org/10.1161/CIRCULATIONAHA.112.109868.
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    • Parikh, Kishan S., Rajiv Agarwal, Amit K. Mehrotra, and Rajiv S. Swamy. “Wellens syndrome: a life-saving diagnosis.” Am J Emerg Med 30, no. 1 (January 2012): 255.e3-255.e5. https://doi.org/10.1016/j.ajem.2010.10.014.
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    • Patel, Ravi B., Jason Ng, Vikram Reddy, Moulin Chokshi, Kishan Parikh, Haris Subacius, Alawi A. Alsheikh-Ali, et al. “Early repolarization associated with ventricular arrhythmias in patients with chronic coronary artery disease.” Circ Arrhythm Electrophysiol 3, no. 5 (October 2010): 489–95. https://doi.org/10.1161/CIRCEP.109.921130.
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    • Somiari, Stella B., Craig D. Shriver, Jing He, Kishan Parikh, Rick Jordan, Jeffrey Hooke, Hai Hu, et al. “Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization.” Cancer Genet Cytogenet 155, no. 2 (December 2004): 108–18. https://doi.org/10.1016/j.cancergencyto.2004.02.023.
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  • Conference Papers

    • Awerbach, Jordan, Kathryn A. Stackhouse, Joanne Lee, Kishan Parikh, Mouhammad Fathallah, and Richard Krasuski. “OUTCOME OF LUNG DISEASE-RELATED PULMONARY HYPERTENSION AND IMPACT OF VASOREACTIVITY.” In Journal of the American College of Cardiology, 71:A1954–A1954. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)32495-1.
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    • Parikh, Kishan S., Steven Lippmann, Melissa Greiner, Paul A. Heidenreich, Clyde W. Yancy, Gregg C. Fonarow, and Adrian F. Hernandez. “The Scope of Sacubitril/Valsartan Eligibility Post-Heart Failure Hospitalization: Findings From the Get With the Guidelines-Heart Failure Registry.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Bazemore, Taylor, Kahli Zietlow, and Kishan Parikh. “DIAGNOSIS OF PULMONIC VALVE INFECTIVE ENDOCARDITIS WITH THE USE OF POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY SCAN.” In Journal of the American College of Cardiology, 67:1031–1031. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)31032-4.
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    • Parikh, K. S., Y. Rao, K. Shen, and S. Rajagopal. “Patient Characteristic Cluster Analysis Predicts Response To Therapy To Oral Treprostinil In Pulmonary Arterial Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • Swaminathan, A. C., A. Poms, K. Kennedy, H. Zhu, E. Gaspard, T. A. Fortin, J. Senick, et al. “Toward Theranostic Biomarkers In Pulmonary Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • Mentz, Robert J., Kishan Parikh, Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, et al. “Implications of Angina Pectoris on Quality of Life, Functional Capacity and Clinical Outcomes in Chronic Heart Failure Patients: Insights From HF-ACTION.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Parikh, Kishan S., Mona Fiuzat, Megan Neely, Tariq Ahmad, G Michael Felker, Ileana Pina, Kirkwood Adams, et al. “ADRENERGIC RECEPTOR POLYMORPHISMS INTERACT WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES ESPECIALLY IN BLACK RACE: RESULTS FROM HF-ACTION DNA SUBSTUDY.” In Journal of the American College of Cardiology, 65:A794–A794. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)60794-x.
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    • Parikh, Kishan S., Mona Fiuzat, Megan Neely, Tariq Ahmad, G Michael Felker, Ileana Pina, Kirkwood Adams, et al. “ALPHA-2C ADRENERGIC RECEPTOR POLYMORPHISM INTERACTS WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES DIFFERENTLY IN BLACK RACE: RESULTS FROM THE HF-ACTION DNA SUBSTUDY.” In Journal of the American College of Cardiology, 65:A964–A964. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)60964-0.
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    • Laffin, Luke J., Amit Patel, Narayan Saha, Julian Barbat, James K. Hall, Matthew Cain, Kishan Parikh, Jay Shah, and Kirk Spencer. “INFERIOR VENA CAVA MEASUREMENT BY FOCUSED CARDIAC ULTRASOUND IN ACUTE DECOMPENSATED HEART FAILURE PREVENTS HOSPITAL READMISSIONS.” In Journal of the American College of Cardiology, 63:A542–A542. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)60542-8.
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    • Czobor, Peter, Kishan Parikh, Sandeep Nathan, Janet Karol, and Atman P. Shah. “Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Venoarterial Extracorporeal Membrane Oxygenation.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Piao, Lin, Yong-Hu Fang, Kishan Parikh, Peter T. Toth, Glenn Marsboom, and Stephen L. Archer. “A First Description of Increased Glutaminolysis in Experimental Right Ventricular Hypertrophy; Association With Ischemia-Induced Activation of cMyc.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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    • Parikh, Kishan, Eugene Greenstein, Jason Ng, Haris Subacius, and Alan Kadish. “J Point ST Elevation Does Not Predict Arrhythmic Events in Dilated Cardiomyopathy.” In Journal of the American College of Cardiology, 53:A120–21. ELSEVIER SCIENCE INC, 2009.
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• Scholarly, Clinical, & Service Activities
• 

  Clinical Activities

  • Pulmonary Vascular Disease Center
    Advanced Heart Failure and Cardiac Transplantation Program
    Wake County Pulmonary Hypertension and Dyspnea Clinic

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