Kishan S Parikh
Assistant Professor of Medicine
Duke University Medical Center
Duke Clinical Research Institute
Duke Clinical Research Institute
Current Research Interests
Pulmonary Hypertension
Heart Failure with Preserved Ejection Fraction
Heart Failure with Reduced Ejection Fraction
Precision Pharmacotherapy
Mobile Health
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2018
- Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2018
Contact Information
- 200 Morris St, Rm 6340, Durham, NC 27705
- P.O. Box 17969, 2400 Pratt St, Rm 0311 Terrace Level, Durham, NC 27705
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kishan.parikh@duke.edu
(919) 668-8820
- Background
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Education, Training, & Certifications
- Advanced Heart Failure, Mechanical Circulatory Support and Transplant Fellowship, Medicine, Duke University School of Medicine 2017 - 2018
- Cardiovascular Disease Fellowship, Medicine, Duke University School of Medicine 2013 - 2017
- Chief Resident, Medicine, University of Chicago 2012 - 2013
- Internal Medicine Residency, Medicine, University of Chicago 2009 - 2012
- M.D., Northwestern University Feinberg School of Medicine 2009
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Medical Licensure
- 2013-00285. North Carolina. 2013
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Leadership & Clinical Positions at Duke
- Director of Pulmonary Hypertension in Wake County
- Research
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Selected Grants
- REDUCE LAP-HF 2018 - 2026
- SPIRRIT - HFpEF awarded by National Institutes of Health 2018 - 2022
- Meteoric 2019 - 2021
- PAH trial of GB002 2019 - 2020
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Benza, Raymond L., Mark Doyle, David Lasorda, Kishan S. Parikh, Priscilla Correa-Jaque, Nima Badie, Greg Ginn, et al. “Monitoring Pulmonary Arterial Hypertension Using an Implantable Hemodynamic Sensor..” Chest 156, no. 6 (December 2019): 1176–86. https://doi.org/10.1016/j.chest.2019.06.010.Full Text Open Access Copy Link to Item
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Regan, Jessica A., Dalane W. Kitzman, Eric S. Leifer, William E. Kraus, Jerome L. Fleg, Daniel E. Forman, David J. Whellan, et al. “Impact of Age on Comorbidities and Outcomes in Heart Failure With Reduced Ejection Fraction..” Jacc Heart Fail 7, no. 12 (December 2019): 1056–65. https://doi.org/10.1016/j.jchf.2019.09.004.Full Text Link to Item
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Edmonston, Daniel L., Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis Abraham, Alexander Grabner, Matthew A. Sparks, and Myles Wolf. “Pulmonary Hypertension Subtypes and Mortality in CKD..” Am J Kidney Dis, November 12, 2019. https://doi.org/10.1053/j.ajkd.2019.08.027.Full Text Link to Item
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Shelburne, Nicholas J., Kishan S. Parikh, Karen Chiswell, Linda K. Shaw, Joseph Sivak, Kristine Arges, Jennifer Tomfohr, et al. “Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension..” Am J Cardiol 124, no. 8 (October 15, 2019): 1298–1304. https://doi.org/10.1016/j.amjcard.2019.07.026.Full Text Link to Item
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Awerbach, Jordan D., Kathryn A. Stackhouse, Joanne Lee, Talal Dahhan, Kishan S. Parikh, and Richard A. Krasuski. “Outcomes of lung disease-associated pulmonary hypertension and impact of elevated pulmonary vascular resistance..” Respir Med 150 (April 2019): 126–30. https://doi.org/10.1016/j.rmed.2019.03.004.Full Text Link to Item
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Parikh, Kishan S., Talal Dahhan, Leigh Nicholl, Nicole Ruopp, Gina-Maria Pomann, Terry Fortin, Victor F. Tapson, and Sudarshan Rajagopal. “Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension..” Sci Rep 9, no. 1 (March 11, 2019). https://doi.org/10.1038/s41598-019-40030-w.Full Text Open Access Copy Link to Item
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Parikh, Kishan S., Shubin Sheng, Bradley G. Hammill, Clyde W. Yancy, Gregg C. Fonarow, Adrian F. Hernandez, and Adam D. DeVore. “Characteristics of Acute Heart Failure Hospitalizations Based on Presenting Severity..” Circ Heart Fail 12, no. 1 (January 2019). https://doi.org/10.1161/CIRCHEARTFAILURE.118.005171.Full Text Link to Item
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Fudim, Marat, Kishan S. Parikh, Allison Dunning, Adam D. DeVore, Robert J. Mentz, Phillip J. Schulte, Paul W. Armstrong, et al. “Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF)..” Am J Cardiol 122, no. 9 (November 1, 2018): 1506–12. https://doi.org/10.1016/j.amjcard.2018.07.023.Full Text Link to Item
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Parikh, Kishan S., Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, et al. “Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials..” Jacc Heart Fail 6, no. 8 (August 2018): 619–32. https://doi.org/10.1016/j.jchf.2018.06.008.Full Text Open Access Copy Link to Item
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Parikh, Kishan S., Mona Fiuzat, Gordon Davis, Megan Neely, Penny Blain-Nelson, David J. Whellan, William T. Abraham, et al. “Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes..” Circ Genom Precis Med 11, no. 8 (August 2018). https://doi.org/10.1161/CIRCGEN.117.002210.Full Text Link to Item
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Laffin, Luke J., Amit V. Patel, Narayan Saha, Julian Barbat, James K. Hall, Matthew Cain, Kishan Parikh, Jay Shah, and Kirk T. Spencer. “Focused cardiac ultrasound as a predictor of readmission in acute decompensated heart failure..” Int J Cardiovasc Imaging 34, no. 7 (July 2018): 1075–79. https://doi.org/10.1007/s10554-018-1317-1.Full Text Link to Item
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Patel, Chetan B., and Kishan S. Parikh. “Cardiac Rehabilitation After Ventricular Assist Device Implantation: A Worthwhile Exercise?.” Jacc Heart Fail 6, no. 2 (February 2018): 140–42. https://doi.org/10.1016/j.jchf.2017.12.009.Full Text Link to Item
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Vemulapalli, Sreekanth, Kishan Parikh, Remy Coeytaux, Victor Hasselblad, Amanda McBroom, Abigail Johnston, Giselle Raitz, et al. “Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins..” Am Heart J 196 (February 2018): 131–43. https://doi.org/10.1016/j.ahj.2017.09.017.Full Text Link to Item
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Parikh, Kishan S., Michael P. Gray, Lewis J. Rubin, David Badesch, and Richard A. Krasuski. “Overdue to understand anticoagulation in pulmonary arterial hypertension..” Pulm Circ 8, no. 1 (January 2018). https://doi.org/10.1177/2045893217743184.Full Text Open Access Copy Link to Item
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Parikh, Kishan S., and Jonathan P. Piccini. “Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure..” Curr Heart Fail Rep 14, no. 6 (December 2017): 529–35. https://doi.org/10.1007/s11897-017-0364-6.Full Text Link to Item
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Parikh, Kishan S., Melissa A. Greiner, Wei Wang, Yuan-I Min, Adolfo Correa, Benjamin F. Banahan, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries..” Epidemiology 28, no. 5 (September 2017): 740–46. https://doi.org/10.1097/EDE.0000000000000689.Full Text Link to Item
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Parikh, Kishan S., Kathryn A. Stackhouse, Stephen A. Hart, Thomas M. Bashore, and Richard A. Krasuski. “Health insurance and racial disparities in pulmonary hypertension outcomes..” Am J Manag Care 23, no. 8 (August 2017): 474–80.Open Access Copy Link to Item
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Parikh, Kishan S., Steven J. Lippmann, Melissa Greiner, Paul A. Heidenreich, Clyde W. Yancy, Gregg C. Fonarow, and Adrian F. Hernandez. “Scope of Sacubitril/Valsartan Eligibility After Heart Failure Hospitalization: Findings From the GWTG-HF Registry (Get With The Guidelines-Heart Failure)..” Circulation 135, no. 21 (May 23, 2017): 2077–80. https://doi.org/10.1161/CIRCULATIONAHA.117.027773.Full Text Link to Item
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Luo, Nancy, Peter Merrill, Kishan S. Parikh, David J. Whellan, Ileana L. Piña, Mona Fiuzat, William E. Kraus, et al. “Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation..” J Am Coll Cardiol 69, no. 13 (April 4, 2017): 1683–91. https://doi.org/10.1016/j.jacc.2017.01.032.Full Text Link to Item
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Parikh, Kishan S., Youlan Rao, Tariq Ahmad, Kai Shen, G Michael Felker, and Sudarshan Rajagopal. “Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis..” Pulm Circ 7, no. 2 (April 2017): 486–93. https://doi.org/10.1177/2045893217705891.Full Text Link to Item
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Parikh, Kishan S., Melissa A. Greiner, Takeki Suzuki, Adam D. DeVore, Chad Blackshear, Joseph F. Maher, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study..” Jama Cardiol 2, no. 2 (February 1, 2017): 172–80. https://doi.org/10.1001/jamacardio.2016.3234.Full Text Link to Item
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Parikh, Kishan S., Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, Ileana L. Piña, et al. “Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION)..” Am J Cardiol 118, no. 8 (October 15, 2016): 1211–16. https://doi.org/10.1016/j.amjcard.2016.07.040.Full Text Link to Item
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Krishnamurthy, Yamini, Lauren B. Cooper, Kishan S. Parikh, G Michael Felker, Carmelo A. Milano, Joseph G. Rogers, Adrian F. Hernandez, and Chetan B. Patel. “Pulmonary Hypertension in the Era of Mechanical Circulatory Support..” Asaio J 62, no. 5 (September 2016): 505–12. https://doi.org/10.1097/MAT.0000000000000408.Full Text Link to Item
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Sharma, Abhinav, Kishan S. Parikh, and Christopher B. Fordyce. “Active Engagement: A Fellow's Guide to Academic Conferences..” J Am Coll Cardiol 67, no. 19 (May 17, 2016): 2306–9. https://doi.org/10.1016/j.jacc.2016.03.503.Full Text Link to Item
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Czobor, Peter, Joseph M. Venturini, Kishan S. Parikh, Elizabeth M. Retzer, Janet Friant, Valluvan Jeevanandam, Mark J. Russo, et al. “Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Patients Treated With Percutaneous Veno-Arterial Extracorporeal Membrane Oxygenation..” J Invasive Cardiol 28, no. 4 (April 2016): 133–38.Link to Item
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Parikh, Kishan S., Sudarshan Rajagopal, Terry Fortin, Victor F. Tapson, and Abby D. Poms. “Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension..” J Cardiovasc Pharmacol 67, no. 4 (April 2016): 322–25. https://doi.org/10.1097/FJC.0000000000000357.Full Text Link to Item
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Zietlow, Kahli, Taylor C. Bazemore, and Kishan S. Parikh. “Diagnosing pulmonic valve infective endocarditis with positron emission tomography-CT..” Bmj Case Rep 2016 (February 1, 2016). https://doi.org/10.1136/bcr-2015-213491.Full Text Link to Item
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Parikh, Kishan S., G Michael Felker, and Marco Metra. “Mode of Death After Acute Heart Failure Hospitalization - A Clue to Possible Mechanisms..” Circ J 80, no. 1 (2016): 17–23. https://doi.org/10.1253/circj.CJ-15-1006.Full Text Link to Item
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Parikh, Kishan S., Sudarshan Rajagopal, Kristine Arges, Tariq Ahmad, Joseph Sivak, Prashant Kaul, Svati H. Shah, et al. “Use of outcome measures in pulmonary hypertension clinical trials..” Am Heart J 170, no. 3 (September 2015): 419-29.e3. https://doi.org/10.1016/j.ahj.2015.06.010.Full Text Link to Item
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Parikh, Kishan S., Tariq Ahmad, and Mona Fiuzat. “Potential applications of pharmacogenomics to heart failure therapies..” Heart Fail Clin 10, no. 4 (October 2014): 599–606. https://doi.org/10.1016/j.hfc.2014.07.007.Full Text Link to Item
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Piao, Lin, Yong-Hu Fang, Kishan Parikh, John J. Ryan, Peter T. Toth, and Stephen L. Archer. “Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension..” J Mol Med (Berl) 91, no. 10 (October 2013): 1185–97. https://doi.org/10.1007/s00109-013-1064-7.Full Text Link to Item
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Piao, Lin, Vaninder K. Sidhu, Yong-Hu Fang, John J. Ryan, Kishan S. Parikh, Zhigang Hong, Peter T. Toth, et al. “FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate..” J Mol Med (Berl) 91, no. 3 (March 2013): 333–46. https://doi.org/10.1007/s00109-012-0982-0.Full Text Link to Item
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Parikh, Kishan S., Amit K. Mehrotra, Mark J. Russo, Roberto M. Lang, Allen Anderson, Valluvan Jeevanandam, Benjamin H. Freed, et al. “Percutaneous transcatheter aortic valve closure successfully treats left ventricular assist device-associated aortic insufficiency and improves cardiac hemodynamics..” Jacc Cardiovasc Interv 6, no. 1 (January 2013): 84–89. https://doi.org/10.1016/j.jcin.2012.08.021.Full Text Link to Item
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Piao, Lin, Yong-Hu Fang, Kishan S. Parikh, John J. Ryan, Karen M. D’Souza, Tiju Theccanat, Peter T. Toth, et al. “GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension..” Circulation 126, no. 24 (December 11, 2012): 2859–69. https://doi.org/10.1161/CIRCULATIONAHA.112.109868.Full Text Link to Item
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Parikh, Kishan S., Rajiv Agarwal, Amit K. Mehrotra, and Rajiv S. Swamy. “Wellens syndrome: a life-saving diagnosis..” Am J Emerg Med 30, no. 1 (January 2012): 255.e3-255.e5. https://doi.org/10.1016/j.ajem.2010.10.014.Full Text Link to Item
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Patel, Ravi B., Jason Ng, Vikram Reddy, Moulin Chokshi, Kishan Parikh, Haris Subacius, Alawi A. Alsheikh-Ali, et al. “Early repolarization associated with ventricular arrhythmias in patients with chronic coronary artery disease..” Circ Arrhythm Electrophysiol 3, no. 5 (October 2010): 489–95. https://doi.org/10.1161/CIRCEP.109.921130.Full Text Link to Item
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Somiari, Stella B., Craig D. Shriver, Jing He, Kishan Parikh, Rick Jordan, Jeffrey Hooke, Hai Hu, et al. “Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization..” Cancer Genet Cytogenet 155, no. 2 (December 2004): 108–18. https://doi.org/10.1016/j.cancergencyto.2004.02.023.Full Text Link to Item
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Conference Papers
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Awerbach, Jordan, Kathryn A. Stackhouse, Joanne Lee, Kishan Parikh, Mouhammad Fathallah, and Richard Krasuski. “OUTCOME OF LUNG DISEASE-RELATED PULMONARY HYPERTENSION AND IMPACT OF VASOREACTIVITY.” In Journal of the American College of Cardiology, 71:A1954–A1954. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)32495-1.Full Text
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Bazemore, Taylor, Kahli Zietlow, and Kishan Parikh. “DIAGNOSIS OF PULMONIC VALVE INFECTIVE ENDOCARDITIS WITH THE USE OF POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY SCAN.” In Journal of the American College of Cardiology, 67:1031–1031. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)31032-4.Full Text
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Parikh, K. S., Y. Rao, K. Shen, and S. Rajagopal. “Patient Characteristic Cluster Analysis Predicts Response To Therapy To Oral Treprostinil In Pulmonary Arterial Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.Link to Item
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Swaminathan, A. C., A. Poms, K. Kennedy, H. Zhu, E. Gaspard, T. A. Fortin, J. Senick, et al. “Toward Theranostic Biomarkers In Pulmonary Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.Link to Item
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Mentz, Robert J., Kishan Parikh, Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, et al. “Implications of Angina Pectoris on Quality of Life, Functional Capacity and Clinical Outcomes in Chronic Heart Failure Patients: Insights From HF-ACTION.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.Link to Item
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Parikh, Kishan S., Mona Fiuzat, Megan Neely, Tariq Ahmad, G Michael Felker, Ileana Pina, Kirkwood Adams, et al. “ADRENERGIC RECEPTOR POLYMORPHISMS INTERACT WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES ESPECIALLY IN BLACK RACE: RESULTS FROM HF-ACTION DNA SUBSTUDY.” In Journal of the American College of Cardiology, 65:A794–A794. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)60794-x.Full Text
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Parikh, Kishan S., Mona Fiuzat, Megan Neely, Tariq Ahmad, G Michael Felker, Ileana Pina, Kirkwood Adams, et al. “ALPHA-2C ADRENERGIC RECEPTOR POLYMORPHISM INTERACTS WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES DIFFERENTLY IN BLACK RACE: RESULTS FROM THE HF-ACTION DNA SUBSTUDY.” In Journal of the American College of Cardiology, 65:A964–A964. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)60964-0.Full Text
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Laffin, Luke J., Amit Patel, Narayan Saha, Julian Barbat, James K. Hall, Matthew Cain, Kishan Parikh, Jay Shah, and Kirk Spencer. “INFERIOR VENA CAVA MEASUREMENT BY FOCUSED CARDIAC ULTRASOUND IN ACUTE DECOMPENSATED HEART FAILURE PREVENTS HOSPITAL READMISSIONS.” In Journal of the American College of Cardiology, 63:A542–A542. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)60542-8.Full Text
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Czobor, Peter, Kishan Parikh, Sandeep Nathan, Janet Karol, and Atman P. Shah. “Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Venoarterial Extracorporeal Membrane Oxygenation.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Piao, Lin, Yong-Hu Fang, Kishan Parikh, Peter T. Toth, Glenn Marsboom, and Stephen L. Archer. “A First Description of Increased Glutaminolysis in Experimental Right Ventricular Hypertrophy; Association With Ischemia-Induced Activation of cMyc.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.Link to Item
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Parikh, Kishan, Eugene Greenstein, Jason Ng, Haris Subacius, and Alan Kadish. “J Point ST Elevation Does Not Predict Arrhythmic Events in Dilated Cardiomyopathy.” In Journal of the American College of Cardiology, 53:A120–21. ELSEVIER SCIENCE INC, 2009.Link to Item
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- Scholarly, Clinical, & Service Activities
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Clinical Activities
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Pulmonary Vascular Disease Center
Advanced Heart Failure and Cardiac Transplantation Program
Wake County Pulmonary Hypertension and Dyspnea Clinic
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Pulmonary Vascular Disease Center
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