Kishan S Parikh | Scholars@Duke

Kishan S Parikh
Assistant Professor of Medicine

Duke University Medical Center
Duke Clinical Research Institute

Current Research Interests

Pulmonary Hypertension
Heart Failure with Preserved Ejection Fraction
Heart Failure with Reduced Ejection Fraction
Precision Pharmacotherapy
Mobile Health

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2018
Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2018

Contact Information

2400 Pratt St, Rm 0311 Terrace Level, Durham, NC 27705
P.O. Box 17969, 2400 Pratt St, Rm 0311 Terrace Level, Durham, NC 27705
kishan.parikh@duke.edu (919) 668-8820

Background
Education, Training, & Certifications
- Advanced Heart Failure, Mechanical Circulatory Support and Transplant Fellowship, Medicine, Duke University School of Medicine 2017 - 2018
- Cardiovascular Disease Fellowship, Medicine, Duke University School of Medicine 2013 - 2017
- Chief Resident, Medicine, University of Chicago 2012 - 2013
- Internal Medicine Residency, Medicine, University of Chicago 2009 - 2012
- M.D., Northwestern University Feinberg School of Medicine 2009
Medical Licensure
- 2013-00285. North Carolina. 2013
Leadership & Clinical Positions at Duke
- Director of Pulmonary Hypertension in Wake County
Research
Selected Grants
- SPIRRIT - HFpEF awarded by National Institutes of Health 2018 - 2022
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Parikh, KS, Dahhan, T, Nicholl, L, Ruopp, N, Pomann, G-M, Fortin, T, Tapson, VF, and Rajagopal, S. "Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension." Scientific Reports 9, no. 1 (March 11, 2019): 4061-null. Full Text
  - Parikh, KS, Sheng, S, Hammill, BG, Yancy, CW, Fonarow, GC, Hernandez, AF, and DeVore, AD. "Characteristics of Acute Heart Failure Hospitalizations Based on Presenting Severity." Circulation. Heart Failure 12, no. 1 (January 2019): e005171-null. Full Text
  - Fudim, M, Parikh, KS, Dunning, A, DeVore, AD, Mentz, RJ, Schulte, PJ, Armstrong, PW, Ezekowitz, JA, Tang, WHW, McMurray, JJV, Voors, AA, Drazner, MH, O'Connor, CM, Hernandez, AF, and Patel, CB. "Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF)." The American Journal of Cardiology 122, no. 9 (November 2018): 1506-1512. Full Text
  - Parikh, KS, Fiuzat, M, Davis, G, Neely, M, Blain-Nelson, P, Whellan, DJ, Abraham, WT, Adams, KF, Felker, GM, Liggett, SB, O'Connor, CM, and Bristow, MR. "Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes." Circulation. Genomic and Precision Medicine 11, no. 8 (August 2018): e002210-null. Full Text
  - Parikh, KS, Sharma, K, Fiuzat, M, Surks, HK, George, JT, Honarpour, N, Depre, C, Desvigne-Nickens, P, Nkulikiyinka, R, Lewis, GD, Gomberg-Maitland, M, O'Connor, CM, Stockbridge, N, Califf, RM, Konstam, MA, Januzzi, JL, Solomon, SD, Borlaug, BA, Shah, SJ, Redfield, MM, and Felker, GM. "Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials." Jacc. Heart Failure 6, no. 8 (August 2018): 619-632. (Review) Full Text Open Access Copy
  - Laffin, LJ, Patel, AV, Saha, N, Barbat, J, Hall, JK, Cain, M, Parikh, K, Shah, J, and Spencer, KT. "Focused cardiac ultrasound as a predictor of readmission in acute decompensated heart failure." The International Journal of Cardiovascular Imaging 34, no. 7 (July 2018): 1075-1079. Full Text
  - Patel, CB, and Parikh, KS. "Cardiac Rehabilitation After Ventricular Assist Device Implantation: A Worthwhile Exercise?." JACC. Heart failure 6, no. 2 (February 2018): 140-142. Full Text
  - Vemulapalli, S, Parikh, K, Coeytaux, R, Hasselblad, V, McBroom, A, Johnston, A, Raitz, G, Crowley, MJ, Lallinger, KR, Jones, WS, and Sanders, GD. "Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins." American Heart Journal 196 (February 2018): 131-143. Full Text
  - Parikh, KS, Gray, MP, Rubin, LJ, Badesch, D, and Krasuski, RA. "Overdue to understand anticoagulation in pulmonary arterial hypertension." Pulmonary Circulation 8, no. 1 (January 2018): 2045893217743184-null. (Letter) Full Text Open Access Copy
  - Parikh, KS, and Piccini, JP. "Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure." Current heart failure reports 14, no. 6 (December 2017): 529-535. (Review) Full Text
  - Parikh, KS, Greiner, MA, Wang, W, Min, Y-I, Correa, A, Banahan, BF, Curtis, LH, Hernandez, AF, O'Brien, EC, and Mentz, RJ. "Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries." Epidemiology (Cambridge, Mass.) 28, no. 5 (September 2017): 740-746. Full Text
  - Parikh, KS, Stackhouse, KA, Hart, SA, Bashore, TM, and Krasuski, RA. "Health insurance and racial disparities in pulmonary hypertension outcomes." The American journal of managed care 23, no. 8 (August 2017): 474-480. Open Access Copy
  - Parikh, KS, Lippmann, SJ, Greiner, M, Heidenreich, PA, Yancy, CW, Fonarow, GC, and Hernandez, AF. "Scope of Sacubitril/Valsartan Eligibility After Heart Failure Hospitalization: Findings From the GWTG-HF Registry (Get With The Guidelines-Heart Failure)." Circulation 135, no. 21 (May 2017): 2077-2080. (Letter) Full Text
  - Luo, N, Merrill, P, Parikh, KS, Whellan, DJ, Piña, IL, Fiuzat, M, Kraus, WE, Kitzman, DW, Keteyian, SJ, O'Connor, CM, and Mentz, RJ. "Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation." Journal of the American College of Cardiology 69, no. 13 (April 2017): 1683-1691. Full Text
  - Parikh, KS, Rao, Y, Ahmad, T, Shen, K, Felker, GM, and Rajagopal, S. "Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis." Pulmonary circulation 7, no. 2 (April 2017): 486-493. Full Text
  - Parikh, KS, Greiner, MA, Suzuki, T, DeVore, AD, Blackshear, C, Maher, JF, Curtis, LH, Hernandez, AF, O'Brien, EC, and Mentz, RJ. "Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study." Jama Cardiology 2, no. 2 (February 2017): 172-180. Full Text
  - Parikh, KS, Coles, A, Schulte, PJ, Kraus, WE, Fleg, JL, Keteyian, SJ, Piña, IL, Fiuzat, M, Whellan, DJ, O'Connor, CM, and Mentz, RJ. "Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION)." The American Journal of Cardiology 118, no. 8 (October 2016): 1211-1216. Full Text
  - Krishnamurthy, Y, Cooper, LB, Parikh, KS, Felker, GM, Milano, CA, Rogers, JG, Hernandez, AF, and Patel, CB. "Pulmonary Hypertension in the Era of Mechanical Circulatory Support." Asaio Journal (American Society for Artificial Internal Organs : 1992) 62, no. 5 (September 2016): 505-512. (Review) Full Text
  - Sharma, A, Parikh, KS, and Fordyce, CB. "Active Engagement: A Fellow's Guide to Academic Conferences." Journal of the American College of Cardiology 67, no. 19 (May 2016): 2306-2309. Full Text
  - Czobor, P, Venturini, JM, Parikh, KS, Retzer, EM, Friant, J, Jeevanandam, V, Russo, MJ, Uriel, N, Paul, JD, Blair, JE, Nathan, S, and Shah, AP. "Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Patients Treated With Percutaneous Veno-Arterial Extracorporeal Membrane Oxygenation." The Journal of invasive cardiology 28, no. 4 (April 2016): 133-138.
  - Parikh, KS, Rajagopal, S, Fortin, T, Tapson, VF, and Poms, AD. "Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension." Journal of cardiovascular pharmacology 67, no. 4 (April 2016): 322-325. Full Text
  - Zietlow, K, Bazemore, TC, and Parikh, KS. "Diagnosing pulmonic valve infective endocarditis with positron emission tomography-CT." BMJ case reports 2016 (February 2016). Full Text
  - Parikh, KS, Felker, GM, and Metra, M. "Mode of Death After Acute Heart Failure Hospitalization　- A Clue to Possible Mechanisms." Circulation journal : official journal of the Japanese Circulation Society 80, no. 1 (January 2016): 17-23. (Review) Full Text
  - Parikh, KS, Rajagopal, S, Arges, K, Ahmad, T, Sivak, J, Kaul, P, Shah, SH, Tapson, V, Velazquez, EJ, Douglas, PS, and Samad, Z. "Use of outcome measures in pulmonary hypertension clinical trials." American heart journal 170, no. 3 (September 2015): 419-29.e3. (Review) Full Text
  - Parikh, KS, Ahmad, T, and Fiuzat, M. "Potential applications of pharmacogenomics to heart failure therapies." Heart failure clinics 10, no. 4 (October 2014): 599-606. (Review) Full Text
  - "Potential Applications of Pharmacogenomics to Heart Failure Therapies." Heart Failure Clinics 10, no. 4 (January 1, 2014): 599-606. (Review) Full Text
  - Piao, L, Fang, Y-H, Parikh, K, Ryan, JJ, Toth, PT, and Archer, SL. "Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension." Journal of Molecular Medicine (Berlin, Germany) 91, no. 10 (October 2013): 1185-1197. Full Text
  - Piao, L, Sidhu, VK, Fang, Y-H, Ryan, JJ, Parikh, KS, Hong, Z, Toth, PT, Morrow, E, Kutty, S, Lopaschuk, GD, and Archer, SL. "FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate." Journal of Molecular Medicine (Berlin, Germany) 91, no. 3 (March 2013): 333-346. Full Text
  - Parikh, KS, Mehrotra, AK, Russo, MJ, Lang, RM, Anderson, A, Jeevanandam, V, Freed, BH, Paul, JD, Karol, J, Nathan, S, and Shah, AP. "Percutaneous transcatheter aortic valve closure successfully treats left ventricular assist device-associated aortic insufficiency and improves cardiac hemodynamics." Jacc. Cardiovascular Interventions 6, no. 1 (January 2013): 84-89. Full Text
  - Piao, L, Fang, Y-H, Parikh, KS, Ryan, JJ, D'Souza, KM, Theccanat, T, Toth, PT, Pogoriler, J, Paul, J, Blaxall, BC, Akhter, SA, and Archer, SL. "GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension." Circulation 126, no. 24 (December 2012): 2859-2869. Full Text
  - Parikh, KS, Agarwal, R, Mehrotra, AK, and Swamy, RS. "Wellens syndrome: a life-saving diagnosis." The American journal of emergency medicine 30, no. 1 (January 2012): 255.e3-255.e5. Full Text
  - Patel, RB, Ng, J, Reddy, V, Chokshi, M, Parikh, K, Subacius, H, Alsheikh-Ali, AA, Nguyen, T, Link, MS, Goldberger, JJ, Ilkhanoff, L, and Kadish, AH. "Early repolarization associated with ventricular arrhythmias in patients with chronic coronary artery disease." Circulation. Arrhythmia and Electrophysiology 3, no. 5 (October 2010): 489-495. Full Text
  - Somiari, SB, Shriver, CD, He, J, Parikh, K, Jordan, R, Hooke, J, Hu, H, Deyarmin, B, Lubert, S, Malicki, L, Heckman, C, and Somiari, RI. "Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization." Cancer genetics and cytogenetics 155, no. 2 (December 2004): 108-118. Full Text
- Conference Papers
  - Awerbach, J, Stackhouse, KA, Lee, J, Parikh, K, Fathallah, M, and Krasuski, R. "OUTCOME OF LUNG DISEASE-RELATED PULMONARY HYPERTENSION AND IMPACT OF VASOREACTIVITY." : Elsevier BV, March 2018. Full Text
  - Bazemore, T, Zietlow, K, and Parikh, K. "DIAGNOSIS OF PULMONIC VALVE INFECTIVE ENDOCARDITIS WITH THE USE OF POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY SCAN." April 2016. Full Text
  - Parikh, KS, Rao, Y, Shen, K, and Rajagopal, S. "Patient Characteristic Cluster Analysis Predicts Response To Therapy To Oral Treprostinil In Pulmonary Arterial Hypertension." International Conference of the American-Thoracic-Society (ATS). San Francisco, CA. May 13, 2016 - May 18, 2016.: AMER THORACIC SOC, January 1, 2016. Link to Item
  - Swaminathan, AC, Poms, A, Kennedy, K, Zhu, H, Gaspard, E, Fortin, TA, Senick, J, Parikh, K, Kelleher, ZT, Fee, B, Rajagopal, S, Murray, K, Tapson, V, McMahon, TJ, and Circulation, P. "Toward Theranostic Biomarkers In Pulmonary Hypertension." 2016. Link to Item
  - Mentz, RJ, Parikh, K, Coles, A, Schulte, PJ, Kraus, WE, Fleg, JL, Keteyian, SJ, Pina, IL, Fiuzat, M, Whellan, DJ, and O'Connor, CM. "Implications of Angina Pectoris on Quality of Life, Functional Capacity and Clinical Outcomes in Chronic Heart Failure Patients: Insights From HF-ACTION." : LIPPINCOTT WILLIAMS & WILKINS, November 10, 2015. Link to Item
  - Parikh, KS, Fiuzat, M, Neely, M, Ahmad, T, Felker, GM, Pina, I, Adams, K, Donahue, M, Kraus, W, Whellan, D, and O’Connor, C. "ADRENERGIC RECEPTOR POLYMORPHISMS INTERACT WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES ESPECIALLY IN BLACK RACE: RESULTS FROM HF-ACTION DNA SUBSTUDY." March 2015. Full Text
  - Parikh, KS, Fiuzat, M, Neely, M, Ahmad, T, Felker, GM, Pina, I, Adams, K, Donahue, M, Kraus, W, Whellan, D, and O’Connor, C. "ALPHA-2C ADRENERGIC RECEPTOR POLYMORPHISM INTERACTS WITH BETA-BLOCKER DOSE EFFECT ON HEART FAILURE OUTCOMES DIFFERENTLY IN BLACK RACE: RESULTS FROM THE HF-ACTION DNA SUBSTUDY." March 2015. Full Text
  - Laffin, LJ, Patel, A, Saha, N, Barbat, J, Hall, JK, Cain, M, Parikh, K, Shah, J, and Spencer, K. "INFERIOR VENA CAVA MEASUREMENT BY FOCUSED CARDIAC ULTRASOUND IN ACUTE DECOMPENSATED HEART FAILURE PREVENTS HOSPITAL READMISSIONS." April 2014. Full Text
  - Czobor, P, Parikh, K, Nathan, S, Karol, J, and Shah, AP. "Sequential Organ Failure Assessment Score at Presentation Predicts Survival in Venoarterial Extracorporeal Membrane Oxygenation." Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX. November 16, 2013 - November 17, 2013.: LIPPINCOTT WILLIAMS & WILKINS, November 26, 2013. Link to Item
  - Piao, L, Fang, Y-H, Parikh, K, Toth, PT, Marsboom, G, and Archer, SL. "A First Description of Increased Glutaminolysis in Experimental Right Ventricular Hypertrophy; Association With Ischemia-Induced Activation of cMyc." : LIPPINCOTT WILLIAMS & WILKINS, November 22, 2011. Link to Item
  - Parikh, K, Greenstein, E, Ng, J, Subacius, H, and Kadish, A. "J Point ST Elevation Does Not Predict Arrhythmic Events in Dilated Cardiomyopathy." 58th Annual Scientific Session of the American-College-of-Cardiology. Orlando, FL. March 28, 2009 - March 31, 2009.: ELSEVIER SCIENCE INC, March 10, 2009. Link to Item
Scholarly, Clinical, & Service Activities
Clinical Activities
- Pulmonary Vascular Disease Center
  Advanced Heart Failure and Cardiac Transplantation Program
  Wake County Pulmonary Hypertension and Dyspnea Clinic

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Education, Training, & Certifications

Medical Licensure

Leadership & Clinical Positions at Duke

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Clinical Activities