Scholars@Duke
Kent James Weinhold

Kent James Weinhold

Joseph W. and Dorothy W. Beard Distinguished Professor Emeritus of Experimental Surgery
Surgery, Surgical Sciences
kent.weinhold@duke.edu
Box 2926 Med Ctr, Durham, NC 27710
204 Surg Oncol Res Fac, Durham, NC 27710

Scholarly Works - Other

Supplementary Figure S1 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S1. A) UMAP visualization of scRNA-seq data colored by patient identity. B) UMAP visualization of scRNA-seq data colored by timepoint (T1 = pre-abemaciclib and ET, T2 = post-abemaciclib and ET). C) Dot plot of proportion ... Full text Cite

Supplementary Figure S10 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplemental Figure 10. Kaplan-Meier plots showing association of (A) myeloid cluster gene signatures and (B) relative cell type deconvolution fraction with survival in metastatic patients in the AURORA (<i>n</i> = 34 patients) ... Full text Cite

Supplementary Figure S5 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S5. Line plot depicting change in proportion of lymphoid cells identified as cluster 6: CTLA4 Tregs for each patient from T1 to T2.</p> ... Full text Cite

Supplementary Figure S9 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S9. A) Heatmap of top 20 differentially expressed genes between myeloid cluster 0: APOC1 TAMs, myeloid cluster 5: TREM2 TAMs, and cluster 7: APOC2 TAMs. B) Heatmap of top 20 enriched pathways derived from genes identifie ... Full text Cite

Supplementary Figure S3 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S3. A) UMAP visualization of G1/S CDKs, CDK4, CDK6, and CDK2. B) C) Heatmap depicting differential expression of CDK4/6 target genes and proliferation markers in each cluster grouped by response. Color indicates average ... Full text Cite

Supplementary Figure S2 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S2. A) UMAP visualization of lymphoid marker genes. B) Relative proportions of lymphoid clusters per patient per timepoint per metastasis site. C) Relative proportions of lymphoid clusters per patient per timepoint per r ... Full text Cite

Supplementary Figure S7 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S7. A) UMAP visualization of G1/S CDKs, CDK4, CDK6, and CDK2. B) C) Heatmap depicting differential expression of CDK4/6 target genes and proliferation markers in each cluster grouped by response. Color indicates average ... Full text Cite

Supplementary Figure S6 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S6. A) UMAP visualization of myeloid cell type markers for macrophages (CD68), M2-like macrophages (CD163), antigen-presenting cells (HLA-DRA), monocytes (CD14), dendritic cells (CD1C), and mast cells (KIT). B) Relative ... Full text Cite

Supplementary Figure S4 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S4. A) Box plot of IFNG expression at T1 and T2 for each T cell cluster grouped by response. Median expression is indicated by green line. Statistical significance determined by two-way ANOVA with post-hoc Tukey-HSD test ... Full text Cite

Supplementary Tables S2-S12 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Table S2. Patient characteristics and number of cells analyzed. Supplementary Table S3. Marker genes for each cluster Supplementary Table S4. ANOVA with Tukey HSD multiple test correction results for cell type population size ... Full text Cite

Supplementary Figure S8 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <p>Supplementary Fig. S8. Heatmap depicting gene set enrichment results identified from genes that were differentially expressed between T1 and T2 for each myeloid cluster in each response group. Color indicates normalized enrichment score wh ... Full text Cite

Data from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Other · August 3, 2026 <div>Abstract Purpose:<p>In advanced estrogen receptor (ER)–positive/human epidermal growth factor receptor 2 (HER2)–negative breast cancer, the combination of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) with endocrine therapy ... Full text Cite

Cellular and humoral immune responses to a canarypox vaccine containing human immunodeficiency virus type 1 Env, Gag, and Pro in combination with rgp120.

Other J Infect Dis · February 15, 2001 Elicitation of both memory cytotoxic T cell responses and human immunodeficiency virus (HIV)-neutralizing antibodies are desirable characteristics of an HIV vaccine regimen. We studied a combination vaccine regimen consisting of a canarypox (CP) vector con ... Full text Link to item Cite

Cytokine profiles in seronegative volunteers immunized with a recombinant canarypox and gp120 prime-boost HIV-1 vaccine. NIAID AIDS Vaccine Evaluation Group.

Other AIDS · July 7, 2000 OBJECTIVES: To study memory T cell proliferative responses and cytokine profiles induced in HIV-1 seronegative volunteers immunized with a live recombinant canarypox vector expressing HIV-1 antigens (ALVAC-HIV) and boosted with a recombinant gp120 subunit ... Full text Link to item Cite

HIV-1MN recombinant glycoprotein 160 vaccine-induced cellular and humoral immunity boosted by HIV-1MN recombinant glycoprotein 120 vaccine. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.

Other AIDS Res Hum Retroviruses · January 20, 1999 We evaluated prime-boost immunization with two recombinant envelope glycoprotein subunit vaccines (HIV-1MN recombinant gp160 vaccine in alum adjuvant [MN rgp160] and HIV-1MN recombinant gp120 vaccine in alum adjuvant [MN rgp120]) for safety and immunogenic ... Full text Link to item Cite

Modulation of immunologic responses to HIV-1MN recombinant gp160 vaccine by dose and schedule of administration. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.

Other Vaccine · March 1998 The safety and immunogenicity of HIV-1MN recombinant gp160 (MN rgp160) vaccine in healthy, uninfected volunteers was tested in a double-blind study with a factorial design. By random assignment, 20 volunteers received three 200 micrograms doses of MN rgp16 ... Full text Link to item Cite

Prospects for development of a vaccine against HIV-related disorders

Other Clinical Immunology Newsletter · January 1, 1987 Full text Cite