Kouros Owzar | Scholars@Duke

Kouros Owzar
Professor of Biostatistics and Bioinformatics

cancer pharmacogenomics
drug induced neuropathy, neutropenia and hypertension
statistical genetics
statistical methods for high-dimensional data
copulas
survival analysis
statistical computing

Current Appointments & Affiliations

Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

2424 Erwin Road Suite 1102, 11074 Hock Plaza, Durham, NC 27705
Duke Box 2721, Durham, NC 27710
kouros.owzar@duke.edu (919) 681-1829

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina at Chapel Hill 2002
Duke Appointment History
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2012 - 2014
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2012
- Assistant Research Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2003 - 2007
- Instructor, Temporary of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2002
Research
Selected Grants
- Race-related alternative splicing: novel targets in prostate cancer awarded by National Institutes of Health 2017 - 2022
- A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2019
- Health Disparity in African Americans: A Meta-analysis of Six Phase III Trials in Metastatic Castration-Resistant Prosta awarded by Department of Defense 2015 - 2018
- Nanoplasmonics-based molecular analysis tool for molecular biomarkers of cancer awarded by National Institutes of Health 2015 - 2018
- Predictive value of the IL6 pathway to direct anti-angiogenic therapy in advanced ovarian cancer awarded by American Association of Obstetricians and Gynecologists Foundation 2017 - 2018
- Administrative Core awarded by University of North Carolina - Chapel Hill 2015 - 2018
- Computational Resources and Dissemination Core awarded by University of North Carolina - Chapel Hill 2015 - 2018
- Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2018
- Integration of CT imaging features with cell-free plasma DNA as biomarkers for early lung cancer detection in patients with indeterminate pulmonary nodules awarded by Society of Thoracic Radiology 2016 - 2018
- Identification of Genetic Determinates for Disparities in African American Patients with Non-Small Cell Lung Cancer awarded by V Foundation for Cancer Research 2016 - 2017
- Immune signatures in metastatic colorectal cancer awarded by Genentech, Inc. 2017
- Pharmacogenomic Analysis of Alliance Breast Cancer Studies awarded by Alliance for Clinical Trials in Oncology Foundation 2015 - 2017
- Pharmacogenomics of Microtubule Targeting Agents awarded by University of California - San Francisco 2016 - 2017
- (PQD5) A novel genetic strategy to predict efficacy of anti-CD20 antibodies awarded by Cornell University 2015 - 2017
- Blood-based Angiome Profiling to Direct Bevacizumab Therapy in Ovarian Cancer awarded by National Institutes of Health 2014 - 2017
- National Clinical Trials Network - Network Group Statistics and DMCs awarded by Mayo Clinic 2014 - 2017
- Preoperative Breast Radiotherapy: A Tool to Provide Individualized and Biologically-Based Radiation Therapy awarded by Gateway for Cancer Research 2015 - 2016
- PAAR Pharmacogenomics of Anticancer Agents Research Group awarded by University of Chicago 2010 - 2015
- (PQD5) A novel genetic strategy to predict efficacy of anti-CD20 antibodies awarded by University of North Carolina - Chapel Hill 2014 - 2015
- Computational Resources and Dissemination Core awarded by University of North Carolina - Chapel Hill 2010 - 2015
- Poly-functional analyses of vaccine-induced T cell responses awarded by National Institutes of Health 2001 - 2012
- Cancer and Leukemia Group B Statistical Center awarded by National Institutes of Health 1982 - 2010
- mTOR Therapy in Prostate Cancer: Signatures of Response and Biology of Resistance awarded by National Institutes of Health 2007 - 2010
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Bahmani, A, Sibley, AB, Parsian, M, Owzar, K, and Mueller, F. "SparkScore: Leveraging apache spark for distributed genomic inference." July 18, 2016. Full Text
  - Wang, X, Owzar, K, Gupta, P, Larson, RA, Mulkey, F, Miller, AA, Lewis, LD, Hurd, D, Vij, R, Ratain, MJ, and Murry, D. "VATALANIB POPULATION PHARMACOKINETICS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME: CALGB 10105 (ALLIANCE)." February 2013. Link to Item
- Journal Articles
  - Holstein, SA, Jung, S-H, Richardson, PG, Hofmeister, CC, Hurd, DD, Hassoun, H, Giralt, S, Stadtmauer, EA, Weisdorf, DJ, Vij, R, Moreb, JS, Callander, NS, van Besien, K, Gentile, TG, Isola, L, Maziarz, RT, Bashey, A, Landau, H, Martin, T, Qazilbash, MH, Rodriguez, C, McClune, B, Schlossman, RL, Smith, SE, Hars, V, Owzar, K, Jiang, C, Boyd, M, Schultz, C, Wilson, M, Hari, P, Pasquini, MC, Horowitz, MM, Shea, TC, Devine, SM, Linker, C, Anderson, KC, and McCarthy, PL. "Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial." The Lancet. Haematology 4, no. 9 (September 2017): e431-e442. Full Text
  - Chen, J, Crutchley, J, Zhang, D, Owzar, K, and Kastan, MB. "Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers." Cancer discovery 7, no. 7 (July 2017): 766-781. Full Text
  - Yin, J, Liu, H, Liu, Z, Owzar, K, Han, Y, Su, L, Wei, Y, Hung, RJ, Brhane, Y, McLaughlin, J, Brennan, P, Bickeboeller, H, Rosenberger, A, Houlston, RS, Caporaso, N, Landi, MT, Heinrich, J, Risch, A, Christiani, DC, Amos, CI, and Wei, Q. "Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus." Molecular carcinogenesis 56, no. 6 (June 2017): 1663-1672. Full Text
  - Han, P, Gao, F, Liu, H, Liu, Z, Shi, Q, Troy, JD, Owzar, K, Lee, W, Zevallos, JP, Sturgis, EM, and Wei, Q. "Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck." Carcinogenesis 38, no. 5 (May 2017): 504-510. Full Text
  - Liu, H, Liu, Z, Wang, Y, Stinchcombe, TE, Owzar, K, Han, Y, Hung, RJ, Brhane, Y, McLaughlin, J, Brennan, P, Bickeböller, H, Rosenberger, A, Houlston, RS, Caporaso, N, Landi, MT, Brüske, I, Risch, A, Wu, X, Ye, Y, Christiani, DC, Amos, CI, Wei, Q, and Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team, . "Functional variants in DCAF4 associated with lung cancer risk in European populations." Carcinogenesis 38, no. 5 (May 2017): 541-551. Full Text
  - Pan, Y, Liu, H, Wang, Y, Kang, X, Liu, Z, Owzar, K, Han, Y, Su, L, Wei, Y, Hung, RJ, Brhane, Y, McLaughlin, J, Brennan, P, Bickeböller, H, Rosenberger, A, Houlston, RS, Caporaso, N, Teresa Landi, M, Heinrich, J, Risch, A, Wu, X, Ye, Y, Christiani, DC, Amos, CI, and Wei, Q. "Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs." Scientific reports 7 (March 17, 2017): 44634-. Full Text
  - Liu, Z, Liu, H, Han, P, Gao, F, Dahlstrom, KR, Li, G, Owzar, K, Zevallos, JP, Sturgis, EM, and Wei, Q. "Apoptotic capacity and risk of squamous cell carcinoma of the head and neck." European journal of cancer (Oxford, England : 1990) 72 (February 2017): 166-176. Full Text
  - Longo, T, McGinley, KF, Freedman, JA, Etienne, W, Wu, Y, Sibley, A, Owzar, K, Gresham, J, Moy, C, Szabo, S, Greshock, J, Zhou, H, Bai, Y, and Inman, BA. "Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer." European urology 70, no. 5 (November 2016): 714-717. Full Text
  - Acharya, CR, McCarthy, JM, Owzar, K, and Allen, AS. "Exploiting expression patterns across multiple tissues to map expression quantitative trait loci." BMC bioinformatics 17 (June 24, 2016): 257-. Full Text
  - Li, Z, and Owzar, K. "Fitting Cox Models with Doubly Censored Data Using Spline-Based Sieve Marginal Likelihood." Scandinavian journal of statistics, theory and applications 43, no. 2 (June 2016): 476-486. Full Text
  - Devine, SM, Owzar, K, Blum, W, Mulkey, F, Stone, RM, Hsu, JW, Champlin, RE, Chen, Y-B, Vij, R, Slack, J, Soiffer, RJ, Larson, RA, Shea, TC, Hars, V, Sibley, AB, Giralt, S, Carter, S, Horowitz, MM, Linker, C, and Alyea, EP. "Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 33, no. 35 (December 2015): 4167-4175. Full Text
  - Dressler, LG, Deal, AM, Owzar, K, Watson, D, Donahue, K, Friedman, PN, Ratain, MJ, and McLeod, HL. "Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance)." Journal of the National Cancer Institute 107, no. 10 (October 2015). Full Text
  - Siamakpour-Reihani, S, Owzar, K, Jiang, C, Turner, T, Deng, Y, Bean, SM, Horton, JK, Berchuck, A, Marks, JR, Dewhirst, MW, and Alvarez Secord, A. "Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma." Gynecologic oncology 139, no. 1 (October 2015): 23-29. Full Text
  - Jiang, Y, Han, Y, Petrovski, S, Owzar, K, Goldstein, DB, and Allen, AS. "Incorporating Functional Information in Tests of Excess De Novo Mutational Load." American Journal of Human Genetics 97, no. 2 (August 6, 2015): 272-283. Full Text
  - Jiang, Y, Han, Y, Petrovski, S, Owzar, K, Goldstein, DB, and Allen, AS. "Incorporating Functional Information in Tests of Excess De Novo Mutational Load." American Journal of Human Genetics 97, no. 2 (August 2015): 272-283. Full Text
  - Glubb, DM, Paré-Brunet, L, Jantus-Lewintre, E, Jiang, C, Crona, D, Etheridge, AS, Mirza, O, Zhang, W, Seiser, EL, Rzyman, W, Jassem, J, Auman, T, Hirsch, FR, Owzar, K, Camps, C, Dziadziuszko, R, and Innocenti, F. "Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 10, no. 7 (July 2015): 1067-1075. Full Text
  - DeBo, RJ, Register, TC, Caudell, DL, Sempowski, GD, Dugan, G, Gray, S, Owzar, K, Jiang, C, Bourland, JD, Chao, NJ, and Cline, JM. "Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques." International journal of radiation biology 91, no. 6 (June 2015): 510-518. Full Text
  - Siamakpour-Reihani, S, Owzar, K, Jiang, C, Scarbrough, PM, Craciunescu, OI, Horton, JK, Dressman, HK, Blackwell, KL, and Dewhirst, MW. "Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival." International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 31, no. 4 (June 2015): 386-395. Full Text
  - Patel, JN, Jiang, C, Hertz, DL, Mulkey, FA, Owzar, K, Halabi, S, Ratain, MJ, Friedman, PN, Small, EJ, Carducci, MA, Mahoney, JF, Kelley, MJ, Morris, MJ, Kelly, WK, and McLeod, HL. "Bevacizumab and the risk of arterial and venous thromboembolism in patients with metastatic, castration-resistant prostate cancer treated on Cancer and Leukemia Group B (CALGB) 90401 (Alliance)." Cancer 121, no. 7 (April 2015): 1025-1031. Full Text
  - Cushman, SM, Jiang, C, Hatch, AJ, Shterev, I, Sibley, AB, Niedzwiecki, D, Venook, AP, Owzar, K, Hurwitz, HI, and Nixon, AB. "Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 5 (March 2015): 1078-1086. Full Text
  - Siamakpour-Reihani, S, Owzar, K, Jiang, C, Turner, T, Deng, Y, Bean, SM, Horton, JK, Berchuck, A, Marks, JR, Dewhirst, MW, and Secord, AA. "Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma." Gynecologic Oncology 139, no. 1 (2015): 23-29. Full Text
  - Beumer, JH, Owzar, K, Lewis, LD, Jiang, C, Holleran, JL, Christner, SM, Blum, W, Devine, S, Kolitz, JE, Linker, C, Vij, R, Alyea, EP, Larson, RA, Ratain, MJ, and Egorin, MJ. "Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103)." Cancer chemotherapy and pharmacology 74, no. 5 (November 2014): 927-938. Full Text
  - Wang, X, Owzar, K, Gupta, P, Larson, RA, Mulkey, F, Miller, AA, Lewis, LD, Hurd, D, Vij, R, Ratain, MJ, Murry, DJ, and Oncology, ACT. "Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome: CALGB 10105 (Alliance)." BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 78, no. 5 (November 2014): 1005-1013. Full Text Link to Item
  - Wolpin, BM, Rizzato, C, Kraft, P, Kooperberg, C, Petersen, GM, Wang, Z, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, J, Canzian, F, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Jacobs, EJ, Kamineni, A, Klein, AP, Kolonel, LN, Kulke, MH, Li, D, Malats, N, Olson, SH, Risch, HA, Sesso, HD, Visvanathan, K, White, E, Zheng, W, Abnet, CC, Albanes, D, Andreotti, G, Austin, MA, Barfield, R, Basso, D, Berndt, SI, Boutron-Ruault, M-C, Brotzman, M, Büchler, MW, and Bueno-de-Mesquita, HB et al. "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer." Nature genetics 46, no. 9 (September 2014): 994-1000. Full Text
  - Van Loon, K, Owzar, K, Jiang, C, Kindler, HL, Mulcahy, MF, Niedzwiecki, D, O'Reilly, EM, Fuchs, C, Innocenti, F, Venook, AP, and Alliance for Clinical Trials in Oncology, . "25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance)." Journal of the National Cancer Institute 106, no. 8 (August 6, 2014). Full Text
  - Chhibber, A, Mefford, J, Stahl, EA, Pendergrass, SA, Baldwin, RM, Owzar, K, Li, M, Winer, EP, Hudis, CA, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, HL, Ratain, MJ, Shulman, LN, Ritchie, MD, Plenge, RM, Witte, JS, and Kroetz, DL. "Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance)." The pharmacogenomics journal 14, no. 4 (August 2014): 336-342. Full Text
  - Corless, CL, Ballman, KV, Antonescu, CR, Kolesnikova, V, Maki, RG, Pisters, PWT, Blackstein, ME, Blanke, CD, Demetri, GD, Heinrich, MC, von Mehren, M, Patel, S, McCarter, MD, Owzar, K, and DeMatteo, RP. "Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 15 (May 2014): 1563-1570. Full Text
  - Lento, W, Ito, T, Zhao, C, Harris, JR, Huang, W, Jiang, C, Owzar, K, Piryani, S, Racioppi, L, Chao, N, and Reya, T. "Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration." Genes & development 28, no. 9 (May 2014): 995-1004. Full Text
  - Ramírez, J, Kim, TW, Liu, W, Myers, JL, Mirkov, S, Owzar, K, Watson, D, Mulkey, F, Gamazon, ER, Stock, W, Undevia, S, Innocenti, F, and Ratain, MJ. "A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469." Pharmacogenet Genomics 24, no. 2 (February 2014): 129-132. Full Text Link to Item
  - Ramírez, J, Kim, TW, Liu, W, Myers, JL, Mirkov, S, Owzar, K, Watson, D, Mulkey, F, Gamazon, ER, Stock, W, Undevia, S, Innocenti, F, and Ratain, MJ. "A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469." Pharmacogenetics and Genomics 24, no. 2 (February 1, 2014): 129-132. Full Text
  - Gauter-Fleckenstein, B, Reboucas, JS, Fleckenstein, K, Tovmasyan, A, Owzar, K, Jiang, C, Batinic-Haberle, I, and Vujaskovic, Z. "Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+)." Redox biology 2 (January 9, 2014): 400-410. Full Text
  - Beumer, JH, Owzar, K, Lewis, LD, Jiang, C, Holleran, JL, Christner, SM, Blum, W, Devine, S, Kolitz, JE, Linker, C, Vij, R, Alyea, EP, Larson, RA, Ratain, MJ, and Egorin, MJ. "Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; An alliance study (CALGB 10503, 19808, and 100103)." Cancer Chemotherapy and Pharmacology 74, no. 5 (January 1, 2014): 927-938. Full Text
  - Chhibber, A, Mefford, J, Stahl, EA, Pendergrass, SA, Baldwin, RM, Owzar, K, Li, M, Winer, EP, Hudis, CA, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, HL, Ratain, MJ, Shulman, LN, Ritchie, MD, Plenge, RM, Witte, JS, and Kroetz, DL. "Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance)." Pharmacogenomics Journal 14, no. 4 (January 1, 2014): 336-342. Full Text
  - Davidson, BA, Rubatt, JM, Corcoran, DL, Teoh, DK, Bernardini, MQ, Grace, LA, Soper, WJ, Berchuck, A, Siamakpour-Reihani, S, Chen, W, Owzar, K, Murphy, SK, and Secord, AA. "Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines." Frontiers in oncology 4 (January 2014): 163-. Full Text
  - Gauter-Fleckenstein, B, Reboucas, JS, Fleckenstein, K, Tovmasyan, A, Owzar, K, Jiang, C, Batinic-Haberle, I, and Vujaskovic, Z. "Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP⁵⁺." Redox Biology 2, no. 1 (January 1, 2014): 400-410. Full Text
  - Fingerlin, TE, Murphy, E, Zhang, W, Peljto, AL, Brown, KK, Steele, MP, Loyd, JE, Cosgrove, GP, Lynch, D, Groshong, S, Collard, HR, Wolters, PJ, Bradford, WZ, Kossen, K, Seiwert, SD, du Bois, RM, Garcia, CK, Devine, MS, Gudmundsson, G, Isaksson, HJ, Kaminski, N, Zhang, Y, Gibson, KF, Lancaster, LH, Cogan, JD, Mason, WR, Maher, TM, Molyneaux, PL, Wells, AU, Moffatt, MF, Selman, M, Pardo, A, Kim, DS, Crapo, JD, Make, BJ, Regan, EA, Walek, DS, Daniel, JJ, Kamatani, Y, Zelenika, D, and Smith, K et al. "Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis." Nat Genet 45, no. 11 (November 2013): 1409-. Full Text Link to Item
  - Garman, KS, Owzar, K, Hauser, ER, Westfall, K, Anderson, BR, Souza, RF, Diehl, AM, Provenzale, D, and Shaheen, NJ. "MicroRNA expression differentiates squamous epithelium from barrett's esophagus and esophageal cancer." Digestive Diseases and Sciences 58, no. 11 (November 1, 2013): 3178-3188. Full Text
  - Garman, KS, Owzar, K, Hauser, ER, Westfall, K, Anderson, BR, Souza, RF, Diehl, AM, Provenzale, D, and Shaheen, NJ. "MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer." Dig Dis Sci 58, no. 11 (November 2013): 3178-3188. Full Text Link to Item
  - Gupta, P, Mulkey, F, Hasserjian, RP, Sanford, BL, Vij, R, Hurd, DD, Odenike, OM, Bloomfield, CD, Owzar, K, Stone, RM, Larson, RA, and Alliance for Clinical Trials in Oncology, . "A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance)." Invest New Drugs 31, no. 5 (October 2013): 1311-1320. Full Text Link to Item
  - DeMatteo, RP, Ballman, KV, Antonescu, CR, Corless, C, Kolesnikova, V, von Mehren, M, McCarter, MD, Norton, J, Maki, RG, Pisters, PWT, Demetri, GD, Brennan, MF, Owzar, K, and American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team for the Alliance for Clinical Trials in Oncology, . "Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor: ACOSOG Z9000 (Alliance) intergroup phase 2 trial." Ann Surg 258, no. 3 (September 2013): 422-429. Full Text Link to Item
  - Patel, JN, Fuchs, CS, Owzar, K, Chen, Z, and McLeod, HL. "Gastric cancer pharmacogenetics: progress or old tripe?." Pharmacogenomics 14, no. 9 (July 2013): 1053-1064. (Review) Full Text Link to Item
  - Kelsey, CR, Jackson, IL, Langdon, S, Owzar, K, Hubbs, J, Vujaskovic, Z, Das, S, and Marks, LB. "Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin." Clin Lung Cancer 14, no. 3 (May 2013): 267-274. Full Text Link to Item
  - Wheeler, HE, Gamazon, ER, Wing, C, Njiaju, UO, Njoku, C, Baldwin, RM, Owzar, K, Jiang, C, Watson, D, Shterev, I, Kubo, M, Zembutsu, H, Winer, EP, Hudis, CA, Shulman, LN, Nakamura, Y, Ratain, MJ, Kroetz, DL, Cancer and Leukemia Group B, , Cox, NJ, and Dolan, ME. "Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy." Clin Cancer Res 19, no. 2 (January 15, 2013): 491-499. Full Text Link to Item
  - DeMatteo, RP, Ballman, KV, Antonescu, CR, Corless, C, Kolesnikova, V, Mehren, MV, McCarter, MD, Norton, J, Maki, RG, Pisters, PWT, Demetri, GD, Brennan, MF, and Owzar, K. "Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor: ACOSOG Z9000 (Alliance) intergroup phase 2 trial." Annals of Surgery 258, no. 3 (2013): 422-428. Full Text
  - Gupta, P, Mulkey, F, Hasserjian, RP, Sanford, BL, Vij, R, Hurd, DD, Odenike, OM, Bloomfield, CD, Owzar, K, Stone, RM, and Larson, RA. "A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance)." Investigational New Drugs 31, no. 5 (2013): 1311-1320. Full Text
  - Lewis, LD, Miller, AA, Owzar, K, Bies, RR, Markova, S, Jiang, C, Kroetz, DL, Egorin, MJ, McLeod, HL, Ratain, MJ, and Alliance for Clinical Trials in Oncology, . "The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)." Pharmacogenet Genomics 23, no. 1 (January 2013): 29-33. Full Text Link to Item
  - Lewis, LD, Miller, AA, Owzar, K, Bies, RR, Markova, S, Jiang, C, Kroetz, DL, Egorin, MJ, McLeod, HL, and Ratain, MJ. "The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)." Pharmacogenetics and Genomics 23, no. 1 (2013): 29-33. Full Text
  - Baldwin, RM, Owzar, K, Zembutsu, H, Chhibber, A, Kubo, M, Jiang, C, Watson, D, Eclov, RJ, Mefford, J, McLeod, HL, Friedman, PN, Hudis, CA, Winer, EP, Jorgenson, EM, Witte, JS, Shulman, LN, Nakamura, Y, Ratain, MJ, and Kroetz, DL. "A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101." Clin Cancer Res 18, no. 18 (September 15, 2012): 5099-5109. Full Text Link to Item
  - Owzar, K, Li, Z, Cox, N, and Jung, S-H. "Power and sample size calculations for SNP association studies with censored time-to-event outcomes." Genet Epidemiol 36, no. 6 (September 2012): 538-548. Full Text Link to Item
  - McCarthy, PL, Owzar, K, Hofmeister, CC, Hurd, DD, Hassoun, H, Richardson, PG, Giralt, S, Stadtmauer, EA, Weisdorf, DJ, Vij, R, Moreb, JS, Callander, NS, Van Besien, K, Gentile, T, Isola, L, Maziarz, RT, Gabriel, DA, Bashey, A, Landau, H, Martin, T, Qazilbash, MH, Levitan, D, McClune, B, Schlossman, R, Hars, V, Postiglione, J, Jiang, C, Bennett, E, Barry, S, Bressler, L, Kelly, M, Seiler, M, Rosenbaum, C, Hari, P, Pasquini, MC, Horowitz, MM, Shea, TC, Devine, SM, Anderson, KC, and Linker, C. "Lenalidomide after stem-cell transplantation for multiple myeloma." N Engl J Med 366, no. 19 (May 10, 2012): 1770-1781. Full Text Link to Item
  - Kelsey, CR, Jackson, L, Langdon, S, Owzar, K, Hubbs, J, Vujaskovic, Z, Das, S, and Marks, LB. "A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint." Int J Radiat Oncol Biol Phys 82, no. 2 (February 1, 2012): e247-e255. Full Text Link to Item
  - Innocenti, F, Owzar, K, Cox, NL, Evans, P, Kubo, M, Zembutsu, H, Jiang, C, Hollis, D, Mushiroda, T, Li, L, Friedman, P, Wang, L, Glubb, D, Hurwitz, H, Giacomini, KM, McLeod, HL, Goldberg, RM, Schilsky, RL, Kindler, HL, Nakamura, Y, and Ratain, MJ. "A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303." Clin Cancer Res 18, no. 2 (January 15, 2012): 577-584. Full Text Link to Item
  - Roberts, AS, Campa, MJ, Gottlin, EB, Jiang, C, Owzar, K, Kindler, HL, Venook, AP, Goldberg, RM, O'Reilly, EM, and Patz, EF. "Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303)." Cancer 118, no. 2 (January 15, 2012): 571-578. Full Text Link to Item
  - McCarthy, PL, Owzar, K, and Anderson, KC. "Dr. McCarthy and colleagues reply." New England Journal of Medicine 367, no. 6 (2012): 574-575. Full Text
  - Lewis, DA, Stashenko, GJ, Akay, OM, Price, LI, Owzar, K, Ginsburg, GS, Chi, J-T, and Ortel, TL. "Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism." Thromb Res 128, no. 6 (December 2011): 536-540. Full Text Link to Item
  - Owzar, K, Barry, WT, and Jung, S-H. "Statistical considerations for analysis of microarray experiments." Clin Transl Sci 4, no. 6 (December 2011): 466-477. (Review) Full Text Link to Item
  - McCarthy, PL, Owzar, K, and Anderson, K. ""Sowing dragon's teeth?" Myeloma and AML." Blood 118, no. 15 (October 13, 2011): 4008-4009. Full Text Link to Item
  - Shea, T, Johnson, J, Westervelt, P, Farag, S, McCarty, J, Bashey, A, Isola, L, Baxter-Lowe, L-A, Kelly, M, Owzar, K, Linker, C, and Cancer and Leukemia Group B, . "Reduced-intensity allogeneic transplantation provides high event-free and overall survival in patients with advanced indolent B cell malignancies: CALGB 109901." Biol Blood Marrow Transplant 17, no. 9 (September 2011): 1395-1403. Full Text Link to Item
  - Klymenko, SV, Belyi, DA, Ross, JR, Owzar, K, Jiang, C, Li, Z, N Minchenko, J, N Kovalenko, A, Bebeshko, VG, and J Chao, N. "Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident." Int J Radiat Biol 87, no. 8 (August 2011): 846-850. Full Text Link to Item
  - Sohn, I, Owzar, K, Lim, J, George, SL, Mackey Cushman, S, and Jung, S-H. "Multiple testing for gene sets from microarray experiments. (Published online)" BMC Bioinformatics 12 (May 26, 2011): 209-. Full Text Open Access Copy Link to Item
  - Frahm, M, Goswami, ND, Owzar, K, Hecker, E, Mosher, A, Cadogan, E, Nahid, P, Ferrari, G, and Stout, JE. "Discriminating between latent and active tuberculosis with multiple biomarker responses." Tuberculosis (Edinb) 91, no. 3 (May 2011): 250-256. Full Text Link to Item
  - Bashey, A, Owzar, K, Johnson, JL, Edwards, PS, Kelly, M, Baxter-Lowe, L-A, Devine, S, Farag, S, Hurd, D, Ball, E, McCarthy, P, Lister, J, Shea, TC, and Linker, C. "Reduced-intensity conditioning allogeneic hematopoietic cell transplantation for patients with hematologic malignancies who relapse following autologous transplantation: a multi-institutional prospective study from the Cancer and Leukemia Group B (CALGB trial 100002)." Biol Blood Marrow Transplant 17, no. 4 (April 2011): 558-565. Full Text Link to Item
  - Mitha, F, Herodotou, H, Borisov, N, Jiang, C, Yoder, J, and Owzar, K. "SNPpy--database management for SNP data from genome wide association studies." PLoS One 6, no. 10 (2011): e24982-. Full Text Open Access Copy Link to Item
  - Sohn, I, Owzar, K, George, SL, Kim, S, and Jung, S-H. "Robust test method for time-course microarray experiments. (Published online)" BMC Bioinformatics 11 (July 22, 2010): 391-. Full Text Open Access Copy Link to Item
  - Chen, BJ, Deoliveira, D, Spasojevic, I, Sempowski, GD, Jiang, C, Owzar, K, Wang, X, Gesty-Palmer, D, Cline, JM, Bourland, JD, Dugan, G, Meadows, SK, Daher, P, Muramoto, G, Chute, JP, and Chao, NJ. "Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. (Published online)" PLoS One 5, no. 6 (June 16, 2010): e11056-. Full Text Open Access Copy Link to Item
  - Shterev, ID, Jung, S-H, George, SL, and Owzar, K. "permGPU: Using graphics processing units in RNA microarray association studies. (Published online)" BMC Bioinformatics 11 (June 16, 2010): 329-. Full Text Open Access Copy Link to Item
  - Gauter-Fleckenstein, B, Fleckenstein, K, Owzar, K, Jiang, C, Rebouças, JS, Batinic-Haberle, I, and Vujaskovic, Z. "Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage." Free Radic Biol Med 48, no. 8 (April 15, 2010): 1034-1043. Full Text Link to Item
  - Halabi, S, and Owzar, K. "The importance of identifying and validating prognostic factors in oncology." Semin Oncol 37, no. 2 (April 2010): e9-18. (Review) Full Text Link to Item
  - Civantos, FJ, Zitsch, RP, Schuller, DE, Agrawal, A, Smith, RB, Nason, R, Petruzelli, G, Gourin, CG, Wong, RJ, Ferris, RL, El Naggar, A, Ridge, JA, Paniello, RC, Owzar, K, McCall, L, Chepeha, DB, Yarbrough, WG, and Myers, JN. "Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial." J Clin Oncol 28, no. 8 (March 10, 2010): 1395-1400. Full Text Link to Item
  - Sohn, I, Owzar, K, George, SL, Kim, S, and Jung, S-H. "A permutation-based multiple testing method for time-course microarray experiments. (Published online)" BMC Bioinformatics 10 (October 15, 2009): 336-. Full Text Link to Item
  - Linker, CA, Owzar, K, Powell, B, Hurd, D, Damon, LE, Archer, LE, Larson, RA, and Cancer and Leukemia Group B, . "Auto-SCT for AML in second remission: CALGB study 9620." Bone Marrow Transplant 44, no. 6 (September 2009): 353-359. Full Text Link to Item
  - Halabi, S, Vogelzang, NJ, Ou, S-S, Owzar, K, Archer, L, and Small, EJ. "Progression-free survival as a predictor of overall survival in men with castrate-resistant prostate cancer." J Clin Oncol 27, no. 17 (June 10, 2009): 2766-2771. Full Text Link to Item
  - Lambotte, O, Ferrari, G, Moog, C, Yates, NL, Liao, H-X, Parks, RJ, Hicks, CB, Owzar, K, Tomaras, GD, Montefiori, DC, Haynes, BF, and Delfraissy, J-F. "Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers." AIDS 23, no. 8 (May 15, 2009): 897-906. Full Text Link to Item
  - Miller, AA, Murry, DJ, Owzar, K, Hollis, DR, Kennedy, EB, Abou-Alfa, G, Desai, A, Hwang, J, Villalona-Calero, MA, Dees, EC, Lewis, LD, Fakih, MG, Edelman, MJ, Millard, F, Frank, RC, Hohl, RJ, and Ratain, MJ. "Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301." J Clin Oncol 27, no. 11 (April 10, 2009): 1800-1805. Full Text Link to Item
  - Dematteo, RP, Ballman, KV, Antonescu, CR, Maki, RG, Pisters, PWT, Demetri, GD, Blackstein, ME, Blanke, CD, von Mehren, M, Brennan, MF, Patel, S, McCarter, MD, Polikoff, JA, Tan, BR, Owzar, K, and American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team, . "Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial." Lancet 373, no. 9669 (March 28, 2009): 1097-1104. Full Text Link to Item
  - Demark-Wahnefried, W, Polascik, TJ, George, SL, Switzer, BR, Madden, JF, Ruffin, MT, Snyder, DC, Owzar, K, Hars, V, Albala, DM, Walther, PJ, Robertson, CN, Moul, JW, Dunn, BK, Brenner, D, Minasian, L, Stella, P, and Vollmer, RT. "Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery." Cancer Epidemiol Biomarkers Prev 17, no. 12 (December 2008): 3577-3587. Full Text Link to Item
  - Heinrich, MC, Owzar, K, Corless, CL, Hollis, D, Borden, EC, Fletcher, CDM, Ryan, CW, von Mehren, M, Blanke, CD, Rankin, C, Benjamin, RS, Bramwell, VH, Demetri, GD, Bertagnolli, MM, and Fletcher, JA. "Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group." J Clin Oncol 26, no. 33 (November 20, 2008): 5360-5367. Full Text Link to Item
  - Owzar, K, Barry, WT, Jung, S-H, Sohn, I, and George, SL. "Statistical challenges in preprocessing in microarray experiments in cancer." Clin Cancer Res 14, no. 19 (October 1, 2008): 5959-5966. (Review) Full Text Link to Item
  - Owzar, K. "Alternate statistical tools and limitations in genetic marker association studies in single-arm drug cancer trials." J Clin Oncol 26, no. 9 (March 20, 2008): 1400-1401. Full Text Link to Item
  - Gauter-Fleckenstein, B, Fleckenstein, K, Owzar, K, Jiang, C, Batinic-Haberle, I, and Vujaskovic, Z. "Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection." Free Radic Biol Med 44, no. 6 (March 15, 2008): 982-989. Full Text Link to Item
  - Owzar, K, and Jung, S-H. "Authors' response." Clinical Trials 5, no. 3 (2008): 223-224. Full Text
  - Owzar, K, and Jung, S-H. "Designing phase II studies in cancer with time-to-event endpoints." Clin Trials 5, no. 3 (2008): 209-221. Full Text Link to Item
  - Owzar, K, Jung, S-H, and Sen, PK. "A copula approach for detecting prognostic genes associated with survival outcome in microarray studies." Biometrics 63, no. 4 (December 2007): 1089-1098. Full Text Link to Item
  - Miller, AA, Murry, DJ, Owzar, K, Hollis, DR, Lewis, LD, Kindler, HL, Marshall, JL, Villalona-Calero, MA, Edelman, MJ, Hohl, RJ, Lichtman, SM, and Ratain, MJ. "Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101." J Clin Oncol 25, no. 21 (July 20, 2007): 3055-3060. Full Text Link to Item
  - Sicklick, JK, Li, Y-X, Jayaraman, A, Kannangai, R, Qi, Y, Vivekanandan, P, Ludlow, JW, Owzar, K, Chen, W, Torbenson, MS, and Diehl, AM. "Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis." Carcinogenesis 27, no. 4 (April 2006): 748-757. Full Text Link to Item
  - Jung, S-H, Owzar, K, George, SL, and Lee, T. "P-value calculation for multistage phase II cancer clinical trials." J Biopharm Stat 16, no. 6 (2006): 765-775. Full Text Link to Item
  - Jung, S-H, Owzar, K, George, SL, and Lee, T. "Rejoinder." Journal of Biopharmaceutical Statistics 16, no. 6 (2006): 781-783. Full Text
  - Roalf, DR, Turetsky, BI, Owzar, K, Balderston, CC, Johnson, SC, Brensinger, CM, Gur, RE, Siegel, SJ, and Moberg, PJ. "Unirhinal olfactory function in schizophrenia patients and first-degree relatives." J Neuropsychiatry Clin Neurosci 18, no. 3 (2006): 389-396. Full Text Link to Item
  - Jung, S-H, Owzar, K, and George, SL. "A multiple testing procedure to associate gene expression levels with survival." Stat Med 24, no. 20 (October 30, 2005): 3077-3088. Full Text Link to Item
  - Skinner, MA, Moley, JA, Dilley, WG, Owzar, K, Debenedetti, MK, and Wells, SA. "Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A." N Engl J Med 353, no. 11 (September 15, 2005): 1105-1113. Full Text Link to Item
  - Owzar, K, and Sen, PK. "Copulas: Concepts and novel applications." Metron 61, no. 3 (December 1, 2003): 323-353.
  - Turetsky, BI, Moberg, PJ, Owzar, K, Johnson, SC, Doty, RL, and Gur, RE. "Physiologic impairment of olfactory stimulus processing in schizophrenia." Biol Psychiatry 53, no. 5 (March 1, 2003): 403-411. Link to Item
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Conference Papers

Journal Articles

Recent Courses