Overview
cancer pharmacogenomics
drug induced neuropathy, neutropenia and hypertension
statistical genetics
statistical methods for high-dimensional data
copulas
survival analysis
statistical computing
drug induced neuropathy, neutropenia and hypertension
statistical genetics
statistical methods for high-dimensional data
copulas
survival analysis
statistical computing
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
·
2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Director, DCI Bioinformatics
·
2013 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Member of the Duke Cancer Institute
·
2013 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
A comprehensive, multi-center, immunogenomic analysis of melanoma brain metastases.
Journal Article Acta Neuropathol Commun · June 2, 2025 BACKGROUND: Melanoma brain metastases (MBM) have a unique molecular profile compared to extracranial metastases (ECM). Description of the biological features and clinical outcomes of MBM will facilitate the design of rational therapies. METHODS: We examine ... Full text Link to item CiteGenomic and immune profiling of breast cancer brain metastases.
Journal Article Acta Neuropathol Commun · May 12, 2025 BACKGROUND: Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic ... Full text Link to item CiteGenomic alterations are associated with response to aromatase inhibitor therapy for ER-positive postmenopausal ductal carcinoma in situ: (CALGB 40903, Alliance).
Journal Article Breast Cancer Res · February 20, 2025 PURPOSE: CALGB 40903 (Alliance) was a phase II single arm multicenter trial conducted in postmenopausal patients diagnosed with estrogen-receptor (ER) positive breast ductal carcinoma in situ (DCIS) without invasion. Patients were treated with the aromatas ... Full text Link to item CiteRecent Grants
Disparate Survival, Disparate Workforce: An Integrated Approach to Improving Head and Neck Cancer Outcomes and Diversity in the Oncology Workforce
ResearchBioinformatics Specialist · Awarded by National Institute of Dental and Craniofacial Research · 2024 - 2029Quantitative Methods for HIV/AIDS Research
Inst. Training Prgm or CMESteering Committee Member · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2028Single Cell and Spatial Analysis of Lethal Breast Cancers
ResearchCo Investigator · Awarded by Department of Defense · 2024 - 2028View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2002
Ph.D.