Kouros Owzar
Professor of Biostatistics & Bioinformatics
cancer pharmacogenomics
drug induced neuropathy, neutropenia and hypertension
statistical genetics
statistical methods for high-dimensional data
copulas
survival analysis
statistical computing
drug induced neuropathy, neutropenia and hypertension
statistical genetics
statistical methods for high-dimensional data
copulas
survival analysis
statistical computing
Current Appointments & Affiliations
- Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
- Director, DCI Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2013
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Contact Information
- 2424 Erwin Road, 8113 Hock Plaza, Durham, NC 27705
- Duke Box 2717, Durham, NC 27710
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kouros.owzar@duke.edu
(919) 681-1829
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2002
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Previous Appointments & Affiliations
- Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014 - 2020
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2012 - 2014
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2012
- Assistant Research Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2003 - 2007
- Instructor, Temporary of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2002
- Research
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Selected Grants
- New computational methods to dynamically pinpointing the subregions carrying disease-associated rare variants awarded by National Institutes of Health 2022 - 2026
- Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD awarded by National Institutes of Health 2015 - 2026
- Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer awarded by National Institutes of Health 2020 - 2025
- Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome awarded by National Institutes of Health 2020 - 2025
- Anti-PD1 in combination with an inhibitor of PCSK9 to increase MHC class I molecule expression on tumor cells as immunotherapy for NSCLC awarded by Department of Defense 2021 - 2024
- Quantitative Methods for HIV/AIDS Research awarded by National Institutes of Health 2018 - 2023
- Preoperative Breast Radiotherapy: A Tool to Provide Individualized and Biologically-Based Radiation Therapy awarded by Gateway for Cancer Research 2015 - 2023
- Ancestry-related RNA splicing and immune expression in metastatic breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2022
- Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer awarded by Department of Defense 2020 - 2022
- Home Transplant to Preserve the Microbiota and Decrease GVHD awarded by American Society of Hematology 2019 - 2022
- Race-related germline genetic variation and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer awarded by Department of Defense 2019 - 2022
- Health Disparity in African Americans: A Meta-analysis of Six Phase III Trials in Metastatic Castration-Resistant Prostate Cancer Men treated with Docetaxel awarded by Department of Defense 2015 - 2021
- Profiling the Adenosine Axis in Metastatic Colorectal Cancer awarded by MedImmune, Inc. 2018 - 2021
- Identification and validation of plasma-based protein biomarkers for cediranib and olaparib awarded by Leidos Biomedical Research, Inc. 2019 - 2020
- A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2020
- Pharmacogenomics of Microtubule Targeting Agents awarded by University of California - San Francisco 2015 - 2020
- Administrative Core awarded by University of North Carolina - Chapel Hill 2015 - 2020
- Computational Resources and Dissemination Core awarded by University of North Carolina - Chapel Hill 2015 - 2020
- Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2020
- Development of a Therapeutic for Brain Tumor Immunotherapy awarded by National Institutes of Health 2018 - 2019
- Identification of Genetic Determinates for Disparities in African American Patients with Non-Small Cell Lung Cancer awarded by V Foundation for Cancer Research 2016 - 2018
- Nanoplasmonics-based molecular analysis tool for molecular biomarkers of cancer awarded by National Institutes of Health 2015 - 2018
- Predictive value of the IL6 pathway to direct anti-angiogenic therapy in advanced ovarian cancer awarded by American Association of Obstetricians and Gynecologists Foundation 2017 - 2018
- Integration of CT imaging features with cell-free plasma DNA as biomarkers for early lung cancer detection in patients with indeterminate pulmonary nodules awarded by Society of Thoracic Radiology 2016 - 2018
- Pharmacogenomic Analysis of Alliance Breast Cancer Studies awarded by Alliance for Clinical Trials in Oncology Foundation 2015 - 2017
- National Clinical Trials Network - Network Group Statistics and DMCs awarded by Mayo Clinic 2014 - 2017
- (PQD5) A novel genetic strategy to predict efficacy of anti-CD20 antibodies awarded by Cornell University 2015 - 2017
- Biomarker Discovery to Direct Bevacizumab Therapy in Ovarian Cancer - Blood-based Angiome Profiling awarded by National Institutes of Health 2014 - 2017
- PAAR Pharmacogenomics of Anticancer Agents Research Group awarded by University of Chicago 2010 - 2015
- (PQD5) A novel genetic strategy to predict efficacy of anti-CD20 antibodies awarded by University of North Carolina - Chapel Hill 2014 - 2015
- Computational Resources and Dissemination Core awarded by University of North Carolina - Chapel Hill 2010 - 2015
- Poly-functional analyses of vaccine-induced T cell responses awarded by National Institutes of Health 2001 - 2012
- Cancer and Leukemia Group B Statistical Center awarded by National Institutes of Health 1982 - 2010
- mTOR Therapy in Prostate Cancer: Signatures of Response and Biology of Resistance awarded by National Institutes of Health 2007 - 2010
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External Relationships
- Gateway for Cancer Research https://www.gatewaycr.org/about-gateway/
- Mt Stephen LLC
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Fang, Jiyuan, Cliburn Chan, Kouros Owzar, Liuyang Wang, Diyuan Qin, Qi-Jing Li, and Jichun Xie. “Clustering Deviation Index (CDI): a robust and accurate internal measure for evaluating scRNA-seq data clustering.” Genome Biol 23, no. 1 (December 27, 2022): 269. https://doi.org/10.1186/s13059-022-02825-5.Full Text Link to Item
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Strand, Siri H., Belén Rivero-Gutiérrez, Kathleen E. Houlahan, Jose A. Seoane, Lorraine M. King, Tyler Risom, Lunden A. Simpson, et al. “Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.” Cancer Cell 40, no. 12 (December 12, 2022): 1521-1536.e7. https://doi.org/10.1016/j.ccell.2022.10.021.Full Text Link to Item
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Lidsky, Michael E., Zechen Wang, Min Lu, Annie Liu, S David Hsu, Shannon J. McCall, Zhecheng Sheng, et al. “Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies.” Npj Precis Oncol 6, no. 1 (October 23, 2022): 75. https://doi.org/10.1038/s41698-022-00320-5.Full Text Link to Item
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Lin, Kevin H., Justine C. Rutter, Abigail Xie, Shane T. Killarney, Camille Vaganay, Chaima Benaksas, Frank Ling, et al. “P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.” Nat Cancer 3, no. 7 (July 2022): 837–51. https://doi.org/10.1038/s43018-022-00394-x.Full Text Link to Item
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Nixon, Andrew B., Alexander B. Sibley, Yingmiao Liu, Ace J. Hatch, Chen Jiang, Flora Mulkey, Mark D. Starr, et al. “Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance).” Clin Cancer Res 28, no. 13 (July 1, 2022): 2779–88. https://doi.org/10.1158/1078-0432.CCR-21-2389.Full Text Link to Item
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Brickey, W June, Michael A. Thompson, Zhecheng Sheng, Zhiguo Li, Kouros Owzar, and Jenny P. Y. Ting. “Re-Examination of the Exacerbating Effect of Inflammasome Components during Radiation Injury.” Radiat Res 197, no. 2 (February 1, 2022): 199–204. https://doi.org/10.1667/RADE-21-00142.1.Full Text Link to Item
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Quintanilha, Julia C. F., Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, et al. “Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.” Br J Cancer 126, no. 2 (February 2022): 265–74. https://doi.org/10.1038/s41416-021-01557-w.Full Text Link to Item
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Quintanilha, Julia C. F., Jin Wang, Alexander B. Sibley, Wei Xu, Osvaldo Espin-Garcia, Chen Jiang, Amy S. Etheridge, et al. “Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens.” Int J Cancer 150, no. 2 (January 15, 2022): 279–89. https://doi.org/10.1002/ijc.33810.Full Text Link to Item
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DiMarco, Ashley V., Xiaodi Qin, Brock J. McKinney, Nina Marie G. Garcia, Sarah C. Van Alsten, Elizabeth A. Mendes, Jeremy Force, et al. “APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses.” Cancer Immunol Res 10, no. 1 (January 2022): 70–86. https://doi.org/10.1158/2326-6066.CIR-21-0146.Full Text Link to Item
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Isaacs, James, Aaron C. Tan, Brent A. Hanks, Xiaofei Wang, Kouros Owzar, James E. Herndon, Scott J. Antonia, Steven Piantadosi, and Mustafa Khasraw. “Clinical Trials with Biologic Primary Endpoints in Immuno-oncology: Concepts and Usage.” Clin Cancer Res 28, no. 1 (January 1, 2022): 13–22. https://doi.org/10.1158/1078-0432.CCR-21-1593.Full Text Link to Item
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Quintanilha, Julia C. F., Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, et al. “Correction: Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.” Br J Cancer 126, no. 1 (January 2022): 162. https://doi.org/10.1038/s41416-021-01617-1.Full Text Link to Item
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Patel, Jai N., Chen Jiang, Kouros Owzar, Flora Mulkey, Jasmine A. Luzum, Harvey J. Mamon, Daniel G. Haller, et al. “Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).” Pharmacogenet Genomics 31, no. 9 (December 1, 2021): 215–20. https://doi.org/10.1097/FPC.0000000000000442.Full Text Link to Item
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Cobb, Lauren Patterson, Sharareh Siamakpour-Reihani, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Chunxiao Zhou, Thomas P. Conrads, et al. “Obesity and altered angiogenic-related gene expression in endometrial cancer.” Gynecol Oncol 163, no. 2 (November 2021): 320–26. https://doi.org/10.1016/j.ygyno.2021.08.010.Full Text Link to Item
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Telzrow, Calla L., Paul J. Zwack, Shannon Esher Righi, Fred S. Dietrich, Cliburn Chan, Kouros Owzar, J Andrew Alspaugh, and Joshua A. Granek. “Comparative analysis of RNA enrichment methods for preparation of Cryptococcus neoformans RNA sequencing libraries.” G3 (Bethesda) 11, no. 11 (October 19, 2021). https://doi.org/10.1093/g3journal/jkab301.Full Text Link to Item
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George, Daniel J., Susan Halabi, Elisabeth I. Heath, A Oliver Sartor, Guru P. Sonpavde, Devika Das, Rhonda L. Bitting, et al. “A prospective trial of abiraterone acetate plus prednisone in Black and White men with metastatic castrate-resistant prostate cancer.” Cancer 127, no. 16 (August 2021): 2954–65. https://doi.org/10.1002/cncr.33589.Full Text
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Lee, Chang-Lung, Kennedy D. Brock, Stephanie Hasapis, Dadong Zhang, Alexander B. Sibley, Xiaodi Qin, Jeremy S. Gresham, et al. “Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma.” Cancer Res 81, no. 14 (July 15, 2021): 3777–90. https://doi.org/10.1158/0008-5472.CAN-20-2823.Full Text Link to Item
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Choueiri, Toni K., Yousef Zakharia, Sumanta Pal, Judit Kocsis, Russell Pachynski, Alexandr Poprach, Andrew B. Nixon, et al. “Clinical Results and Biomarker Analyses of Axitinib and TRC105 versus Axitinib Alone in Patients with Advanced or Metastatic Renal Cell Carcinoma (TRAXAR).” Oncologist 26, no. 7 (July 2021): 560-e1103. https://doi.org/10.1002/onco.13777.Full Text Link to Item
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Al Abo, Muthana, Terry Hyslop, Xiaodi Qin, Kouros Owzar, Daniel J. George, Steven R. Patierno, and Jennifer A. Freedman. “Differential alternative RNA splicing and transcription events between tumors from African American and White patients in The Cancer Genome Atlas.” Genomics 113, no. 3 (May 2021): 1234–46. https://doi.org/10.1016/j.ygeno.2021.02.020.Full Text Link to Item
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Deveaux, April E., Tyler A. Allen, Muthana Al Abo, Xiaodi Qin, Dadong Zhang, Brendon M. Patierno, Lin Gu, et al. “RNA splicing and aggregate gene expression differences in lung squamous cell carcinoma between patients of West African and European ancestry.” Lung Cancer 153 (March 2021): 90–98. https://doi.org/10.1016/j.lungcan.2021.01.015.Full Text Link to Item
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Chen, Jing, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Jennifer J. McCann, and Michael B. Kastan. “DNA-Damage-Induced Alternative Splicing of p53.” Cancers (Basel) 13, no. 2 (January 12, 2021). https://doi.org/10.3390/cancers13020251.Full Text Link to Item
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Innocenti, Federico, Alexander B. Sibley, Sushant A. Patil, Amy S. Etheridge, Chen Jiang, Fang-Shu Ou, Stefanie D. Howell, et al. “Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 27, no. 1 (January 2021): 267–75. https://doi.org/10.1158/1078-0432.ccr-20-2021.Full Text
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Wisdom, Amy J., Yvonne M. Mowery, Cierra S. Hong, Jonathon E. Himes, Barzin Y. Nabet, Xiaodi Qin, Dadong Zhang, et al. “Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.” Nat Commun 11, no. 1 (December 17, 2020): 6410. https://doi.org/10.1038/s41467-020-19917-0.Full Text Link to Item
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Innocenti, F., J. Wang, A. Sibley, C. Jiang, A. Etheridge, F. Shen, J. Patel, et al. “Bevacizumab-induced hypertension and proteinuria: A genome-wide analysis of more than 1,000 patients.” European Journal of Cancer 138 (October 1, 2020): S9–10. https://doi.org/10.1016/S0959-8049(20)31090-X.Full Text
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Liu, Yingmiao, Jing Lyu, Kirsten Bell Burdett, Alexander B. Sibley, Ace J. Hatch, Mark D. Starr, John C. Brady, et al. “Prognostic and Predictive Biomarkers in Patients with Metastatic Colorectal Cancer Receiving Regorafenib.” Mol Cancer Ther 19, no. 10 (October 2020): 2146–54. https://doi.org/10.1158/1535-7163.MCT-20-0249.Full Text Link to Item
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Huang, Jianguo, Mohit Sachdeva, Eric Xu, Timothy J. Robinson, Lixia Luo, Yan Ma, Nerissa T. Williams, et al. “The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways.” Mol Cancer Res 18, no. 10 (October 2020): 1534–44. https://doi.org/10.1158/1541-7786.MCR-19-1170.Full Text Link to Item
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Walens, Andrea, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, et al. “Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence.” Nature Communications 11, no. 1 (October 2020): 5017. https://doi.org/10.1038/s41467-020-18730-z.Full Text
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Chua, Katherina C., Chenling Xiong, Carol Ho, Taisei Mushiroda, Chen Jiang, Flora Mulkey, Dongbing Lai, et al. “Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.” Clin Pharmacol Ther 108, no. 3 (September 2020): 625–34. https://doi.org/10.1002/cpt.1958.Full Text Link to Item
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Wu, Yuan, Xiaofei Wang, Jiaxing Lin, Beilin Jia, and Kouros Owzar. “Predictive accuracy of markers or risk scores for interval censored survival data.” Stat Med 39, no. 18 (August 15, 2020): 2437–46. https://doi.org/10.1002/sim.8547.Full Text Link to Item
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Holstein, Sarah A., Vera J. Suman, Kouros Owzar, Katelyn Santo, Don M. Benson, Thomas C. Shea, Thomas Martin, et al. “Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma.” Biol Blood Marrow Transplant 26, no. 8 (August 2020): 1414–24. https://doi.org/10.1016/j.bbmt.2020.03.028.Full Text Link to Item
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Crawford, Bridget M., Hsin-Neng Wang, Christina Stolarchuk, Richard J. von Furstenberg, Pietro Strobbia, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Katherine S. Garman, and Tuan Vo-Dinh. “Plasmonic nanobiosensors for detection of microRNA cancer biomarkers in clinical samples.” The Analyst 145, no. 13 (July 2020): 4587–94. https://doi.org/10.1039/d0an00193g.Full Text
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Alvarez Secord, Angeles, Kirsten Bell Burdett, Kouros Owzar, David Tritchler, Alexander B. Sibley, Yingmiao Liu, Mark D. Starr, et al. “Predictive Blood-Based Biomarkers in Patients with Epithelial Ovarian Cancer Treated with Carboplatin and Paclitaxel with or without Bevacizumab: Results from GOG-0218.” Clin Cancer Res 26, no. 6 (March 15, 2020): 1288–96. https://doi.org/10.1158/1078-0432.CCR-19-0226.Full Text Link to Item
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Siamakpour-Reihani, Sharareh, Lauren Patterson Cobb, Chen Jiang, Dadong Zhang, Rebecca A. Previs, Kouros Owzar, Andrew B. Nixon, and Angeles Alvarez Secord. “Differential expression of immune related genes in high-grade ovarian serous carcinoma.” Gynecol Oncol 156, no. 3 (March 2020): 662–68. https://doi.org/10.1016/j.ygyno.2019.12.019.Full Text Link to Item
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Vij, Ravi, Jennifer Le-Rademacher, Kristina Laumann, Vera Hars, Kouros Owzar, Tsiporah Shore, Sumithira Vasu, et al. “A Phase II Multicenter Study of the Addition of Azacitidine to Reduced-Intensity Conditioning Allogeneic Transplant for High-Risk Myelodysplasia (and Older Patients with Acute Myeloid Leukemia): Results of CALGB 100801 (Alliance).” Biol Blood Marrow Transplant 25, no. 10 (October 2019): 1984–92. https://doi.org/10.1016/j.bbmt.2019.06.007.Full Text Link to Item
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Innocenti, Federico, Chen Jiang, Alexander B. Sibley, Stefanie Denning, Amy S. Etheridge, Dorothy Watson, Donna Niedzwiecki, et al. “An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance).” Pharmacogenet Genomics 29, no. 6 (August 2019): 123–31. https://doi.org/10.1097/FPC.0000000000000375.Full Text Link to Item
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Lee, Chang-Lung, Yvonne M. Mowery, Andrea R. Daniel, Dadong Zhang, Alexander B. Sibley, Joe R. Delaney, Amy J. Wisdom, et al. “Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.” Jci Insight 4, no. 13 (July 11, 2019). https://doi.org/10.1172/jci.insight.128698.Full Text Link to Item
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Lin, Jiaxing, Alexander Sibley, Ivo Shterev, Andrew Nixon, Federico Innocenti, Cliburn Chan, and Kouros Owzar. “fastJT: An R package for robust and efficient feature selection for machine learning and genome-wide association studies.” Bmc Bioinformatics 20, no. 1 (June 13, 2019): 333. https://doi.org/10.1186/s12859-019-2869-3.Full Text Link to Item
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Li, Zhiguo, Jiaxing Lin, Alexander B. Sibley, Tracy Truong, Katherina C. Chua, Yu Jiang, Janice McCarthy, Deanna L. Kroetz, Andrew Allen, and Kouros Owzar. “Efficient estimation of grouped survival models.” Bmc Bioinformatics 20, no. 1 (May 28, 2019): 269. https://doi.org/10.1186/s12859-019-2899-x.Full Text Link to Item
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Rashkin, Sara R., Katherina C. Chua, Carol Ho, Flora Mulkey, Chen Jiang, Tasei Mushiroda, Michiaki Kubo, et al. “A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).” Clin Pharmacol Ther 105, no. 3 (March 2019): 738–45. https://doi.org/10.1002/cpt.1241.Full Text Link to Item
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Brander, Danielle M., Daphne R. Friedman, Alicia D. Volkheimer, Dale J. Christensen, Laura Z. Rassenti, Thomas J. Kipps, Eross Guadalupe, et al. “SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia.” Br J Haematol 184, no. 4 (February 2019): 605–15. https://doi.org/10.1111/bjh.15677.Full Text Link to Item
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Hale, Laura P., Gowrisankar Rajam, George M. Carlone, Chen Jiang, Kouros Owzar, Greg Dugan, David Caudell, et al. “Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.” Plos One 14, no. 2 (2019): e0210663. https://doi.org/10.1371/journal.pone.0210663.Full Text Link to Item
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Li, Zhiguo, Xiaofei Wang, Yuan Wu, and Kouros Owzar. “Sample size calculation for studies with grouped survival data.” Stat Med 37, no. 27 (November 30, 2018): 3904–17. https://doi.org/10.1002/sim.7847.Full Text Open Access Copy Link to Item
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Innocenti, Federico, Chen Jiang, Alexander B. Sibley, Amy S. Etheridge, Ace J. Hatch, Stefanie Denning, Donna Niedzwiecki, et al. “Genetic variation determines VEGF-A plasma levels in cancer patients.” Sci Rep 8, no. 1 (November 5, 2018): 16332. https://doi.org/10.1038/s41598-018-34506-4.Full Text Link to Item
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Lin, Jiaxing, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S. Damrauer, Scott Floyd, et al. “bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens.” Bioinformatics 34, no. 20 (October 15, 2018): 3581–83. https://doi.org/10.1093/bioinformatics/bty402.Full Text Link to Item
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Li, Megan, Flora Mulkey, Chen Jiang, Bert H. O’Neil, Bryan P. Schneider, Fei Shen, Paula N. Friedman, et al. “Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance).” Clin Cancer Res 24, no. 19 (October 1, 2018): 4734–44. https://doi.org/10.1158/1078-0432.CCR-17-1523.Full Text Link to Item
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Innocenti, F., K. Owzar, C. Jiang, A. S. Etheridge, R. Gordân, A. B. Sibley, F. Mulkey, et al. “The Vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.” Plos One 13, no. 8 (August 1, 2018). https://doi.org/10.1371/journal.pone.0202272.Full Text
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Duan, Bensong, Jiangfeng Hu, Hongliang Liu, Yanru Wang, Hongyu Li, Shun Liu, Jichun Xie, et al. “Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.” Int J Cancer 142, no. 7 (April 1, 2018): 1322–31. https://doi.org/10.1002/ijc.31171.Full Text Open Access Copy Link to Item
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Cline, John Mark, Greg Dugan, John Daniel Bourland, Donna L. Perry, Joel D. Stitzel, Ashley A. Weaver, Chen Jiang, et al. “Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.” Antioxidants (Basel) 7, no. 3 (March 7, 2018). https://doi.org/10.3390/antiox7030040.Full Text Link to Item
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Feng, Yun, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Kouros Owzar, Jichun Xie, et al. “Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.” Mol Carcinog 57, no. 2 (February 2018): 216–24. https://doi.org/10.1002/mc.22748.Full Text Open Access Copy Link to Item
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Sucheston-Campbell, Lara E., Alyssa I. Clay-Gilmour, William E. Barlow, G Thomas Budd, Daniel O. Stram, Christopher A. Haiman, Xin Sheng, et al. “Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.” Pharmacogenet Genomics 28, no. 2 (February 2018): 49–55. https://doi.org/10.1097/FPC.0000000000000318.Full Text Link to Item
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Sibley, Alexander, Zhiguo Li, Yu Jiang, Yi-Ju Li, Cliburn Chan, Andrew Allen, and Kouros Owzar. “Facilitating the Calculation of the Efficient Score Using Symbolic Computing.” Am Stat 72, no. 2 (2018): 199–205. https://doi.org/10.1080/00031305.2017.1392361.Full Text Link to Item
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Poe, Jonathan C., Wei Jia, Hsuan Su, Sarah Anand, Jeremy J. Rose, Prasanthi V. Tata, Amy N. Suthers, et al. “An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.” Blood 130, no. 19 (November 9, 2017): 2131–45. https://doi.org/10.1182/blood-2017-05-782466.Full Text Link to Item
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Acharya, Chaitanya R., Kouros Owzar, and Andrew S. Allen. “Mapping eQTL by leveraging multiple tissues and DNA methylation.” Bmc Bioinformatics 18, no. 1 (October 18, 2017): 455. https://doi.org/10.1186/s12859-017-1856-9.Full Text Link to Item
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Holstein, Sarah A., Sin-Ho Jung, Paul G. Richardson, Craig C. Hofmeister, David D. Hurd, Hani Hassoun, Sergio Giralt, et al. “Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial.” Lancet Haematol 4, no. 9 (September 2017): e431–42. https://doi.org/10.1016/S2352-3026(17)30140-0.Full Text Link to Item
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Chen, Jing, John Crutchley, Dadong Zhang, Kouros Owzar, and Michael B. Kastan. “Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.” Cancer Discov 7, no. 7 (July 2017): 766–81. https://doi.org/10.1158/2159-8290.CD-16-0908.Full Text Link to Item
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Heinrich, Michael C., Cathryn Rankin, Charles D. Blanke, George D. Demetri, Ernest C. Borden, Christopher W. Ryan, Margaret von Mehren, et al. “Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033.” Jama Oncol 3, no. 7 (July 1, 2017): 944–52. https://doi.org/10.1001/jamaoncol.2016.6728.Full Text Link to Item
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Yin, Jieyun, Hongliang Liu, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, et al. “Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.” Mol Carcinog 56, no. 6 (June 2017): 1663–72. https://doi.org/10.1002/mc.22622.Full Text Link to Item
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Han, Peng, Fengqin Gao, Hongliang Liu, Zhensheng Liu, Qiong Shi, Jesse D. Troy, Kouros Owzar, et al. “Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck.” Carcinogenesis 38, no. 5 (May 1, 2017): 504–10. https://doi.org/10.1093/carcin/bgx028.Full Text Link to Item
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Liu, Hongliang, Zhensheng Liu, Yanru Wang, Thomas E. Stinchcombe, Kouros Owzar, Younghun Han, Rayjean J. Hung, et al. “Functional variants in DCAF4 associated with lung cancer risk in European populations.” Carcinogenesis 38, no. 5 (May 1, 2017): 541–51. https://doi.org/10.1093/carcin/bgx033.Full Text Link to Item
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Pan, Yongchu, Hongliang Liu, Yanru Wang, Xiaozheng Kang, Zhensheng Liu, Kouros Owzar, Younghun Han, et al. “Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.” Sci Rep 7 (March 17, 2017): 44634. https://doi.org/10.1038/srep44634.Full Text Open Access Copy Link to Item
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Liu, Zhensheng, Hongliang Liu, Peng Han, Fengqin Gao, Kristina R. Dahlstrom, Guojun Li, Kouros Owzar, Jose P. Zevallos, Erich M. Sturgis, and Qingyi Wei. “Apoptotic capacity and risk of squamous cell carcinoma of the head and neck.” European Journal of Cancer (Oxford, England : 1990) 72 (February 2017): 166–76. https://doi.org/10.1016/j.ejca.2016.11.018.Full Text
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Longo, Thomas, Kathleen F. McGinley, Jennifer A. Freedman, Wiguins Etienne, Yuan Wu, Alexander Sibley, Kouros Owzar, et al. “Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer.” Eur Urol 70, no. 5 (November 2016): 714–17. https://doi.org/10.1016/j.eururo.2016.07.049.Full Text Link to Item
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Yuan, Hua, Hongliang Liu, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, et al. “A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.” Sci Rep 6 (October 7, 2016): 34234. https://doi.org/10.1038/srep34234.Full Text Open Access Copy Link to Item
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Hertz, Daniel L., Kouros Owzar, Sherrie Lessans, Claudia Wing, Chen Jiang, William Kevin Kelly, Jai Patel, et al. “Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.” Clin Cancer Res 22, no. 19 (October 1, 2016): 4890–4900. https://doi.org/10.1158/1078-0432.CCR-15-2823.Full Text Link to Item
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Hatch, Ace J., Alexander B. Sibley, Mark D. Starr, J Chris Brady, Chen Jiang, Jingquan Jia, Daniel L. Bowers, et al. “Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance).” Cancer Med 5, no. 9 (September 2016): 2249–60. https://doi.org/10.1002/cam4.806.Full Text Link to Item
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Friedman, Daphne R., Alexander B. Sibley, Kouros Owzar, Kari G. Chaffee, Susan Slager, Neil E. Kay, Curtis A. Hanson, et al. “Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study.” Am J Hematol 91, no. 7 (July 2016): 687–91. https://doi.org/10.1002/ajh.24376.Full Text Link to Item
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Acharya, Chaitanya R., Janice M. McCarthy, Kouros Owzar, and Andrew S. Allen. “Exploiting expression patterns across multiple tissues to map expression quantitative trait loci.” Bmc Bioinformatics 17 (June 24, 2016): 257. https://doi.org/10.1186/s12859-016-1123-5.Full Text Link to Item
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Li, Zhiguo, and Kouros Owzar. “Fitting Cox Models with Doubly Censored Data Using Spline-Based Sieve Marginal Likelihood.” Scand Stat Theory Appl 43, no. 2 (June 2016): 476–86. https://doi.org/10.1111/sjos.12186.Full Text Link to Item
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Kang, Xiaozheng, Hongliang Liu, Mark W. Onaitis, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, et al. “Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.” Carcinogenesis 37, no. 3 (March 2016): 280–89. https://doi.org/10.1093/carcin/bgw014.Full Text Link to Item
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Devine, Steven M., Kouros Owzar, William Blum, Flora Mulkey, Richard M. Stone, Jack W. Hsu, Richard E. Champlin, et al. “Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502.” J Clin Oncol 33, no. 35 (December 10, 2015): 4167–75. https://doi.org/10.1200/JCO.2015.62.7273.Full Text Link to Item
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Dressler, Lynn G., Allison M. Deal, Kouros Owzar, Dorothy Watson, Katherine Donahue, Paula N. Friedman, Mark J. Ratain, and Howard L. McLeod. “Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance).” J Natl Cancer Inst 107, no. 10 (October 2015). https://doi.org/10.1093/jnci/djv188.Full Text Link to Item
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Siamakpour-Reihani, Sharareh, Kouros Owzar, Chen Jiang, Taylor Turner, Yiwen Deng, Sarah M. Bean, Janet K. Horton, et al. “Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.” Gynecol Oncol 139, no. 1 (October 2015): 23–29. https://doi.org/10.1016/j.ygyno.2015.08.001.Full Text Link to Item
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Jiang, Yu, Yujun Han, Slavé Petrovski, Kouros Owzar, David B. Goldstein, and Andrew S. Allen. “Incorporating Functional Information in Tests of Excess De Novo Mutational Load.” Am J Hum Genet 97, no. 2 (August 6, 2015): 272–83. https://doi.org/10.1016/j.ajhg.2015.06.013.Full Text Link to Item
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Glubb, Dylan M., Laia Paré-Brunet, Eloisa Jantus-Lewintre, Chen Jiang, Daniel Crona, Amy S. Etheridge, Osman Mirza, et al. “Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer.” J Thorac Oncol 10, no. 7 (July 2015): 1067–75. https://doi.org/10.1097/JTO.0000000000000549.Full Text Link to Item
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DeBo, Ryne J., Thomas C. Register, David L. Caudell, Gregory D. Sempowski, Gregory Dugan, Shauna Gray, Kouros Owzar, et al. “Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.” Int J Radiat Biol 91, no. 6 (June 2015): 510–18. https://doi.org/10.3109/09553002.2015.1028597.Full Text Link to Item
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Siamakpour-Reihani, Sharareh, Kouros Owzar, Chen Jiang, Peter M. Scarbrough, Oana I. Craciunescu, Janet K. Horton, Holly K. Dressman, Kimberly L. Blackwell, and Mark W. Dewhirst. “Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.” Int J Hyperthermia 31, no. 4 (June 2015): 386–95. https://doi.org/10.3109/02656736.2015.1016557.Full Text Link to Item
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Patel, Jai N., Chen Jiang, Daniel L. Hertz, Flora A. Mulkey, Kouros Owzar, Susan Halabi, Mark J. Ratain, et al. “Bevacizumab and the risk of arterial and venous thromboembolism in patients with metastatic, castration-resistant prostate cancer treated on Cancer and Leukemia Group B (CALGB) 90401 (Alliance).” Cancer 121, no. 7 (April 1, 2015): 1025–31. https://doi.org/10.1002/cncr.29169.Full Text Link to Item
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Cushman, Stephanie M., Chen Jiang, Ace J. Hatch, Ivo Shterev, Alexander B. Sibley, Donna Niedzwiecki, Alan P. Venook, Kouros Owzar, Herbert I. Hurwitz, and Andrew B. Nixon. “Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance).” Clin Cancer Res 21, no. 5 (March 1, 2015): 1078–86. https://doi.org/10.1158/1078-0432.CCR-14-2313.Full Text Link to Item
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Beumer, Jan H., Kouros Owzar, Lionel D. Lewis, Chen Jiang, Julianne L. Holleran, Susan M. Christner, William Blum, et al. “Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103).” Cancer Chemother Pharmacol 74, no. 5 (November 2014): 927–38. https://doi.org/10.1007/s00280-014-2571-0.Full Text Link to Item
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Wolpin, Brian M., Cosmeri Rizzato, Peter Kraft, Charles Kooperberg, Gloria M. Petersen, Zhaoming Wang, Alan A. Arslan, et al. “Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.” Nat Genet 46, no. 9 (September 2014): 994–1000. https://doi.org/10.1038/ng.3052.Full Text Link to Item
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Chhibber, A., J. Mefford, E. A. Stahl, S. A. Pendergrass, R. M. Baldwin, K. Owzar, M. Li, et al. “Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).” Pharmacogenomics J 14, no. 4 (August 2014): 336–42. https://doi.org/10.1038/tpj.2014.2.Full Text Link to Item
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Van Loon, Katherine, Kouros Owzar, Chen Jiang, Hedy L. Kindler, Mary F. Mulcahy, Donna Niedzwiecki, Eileen M. O’Reilly, et al. “25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance).” J Natl Cancer Inst 106, no. 8 (August 2014). https://doi.org/10.1093/jnci/dju185.Full Text Link to Item
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Corless, Christopher L., Karla V. Ballman, Cristina R. Antonescu, Violetta Kolesnikova, Robert G. Maki, Peter W. T. Pisters, Martin E. Blackstein, et al. “Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial.” J Clin Oncol 32, no. 15 (May 20, 2014): 1563–70. https://doi.org/10.1200/JCO.2013.51.2046.Full Text Link to Item
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Lento, William, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, et al. “Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration.” Genes Dev 28, no. 9 (May 1, 2014): 995–1004. https://doi.org/10.1101/gad.231944.113.Full Text Link to Item
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Ramírez, Jacqueline, Tae Won Kim, Wanqing Liu, Jamie L. Myers, Snezana Mirkov, Kouros Owzar, Dorothy Watson, et al. “A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.” Pharmacogenet Genomics 24, no. 2 (February 2014): 129–32. https://doi.org/10.1097/FPC.0000000000000023.Full Text Link to Item
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Agarwal, Pankaj, and Kouros Owzar. “Next generation distributed computing for cancer research.” Cancer Inform 13, no. Suppl 7 (2014): 97–109. https://doi.org/10.4137/CIN.S16344.Full Text Link to Item
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Chhibber, A., J. Mefford, E. A. Stahl, S. A. Pendergrass, R. M. Baldwin, K. Owzar, M. Li, et al. “Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).” Pharmacogenomics Journal 14, no. 4 (January 1, 2014): 336–42. https://doi.org/10.1038/tpj.2014.2.Full Text
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Davidson, Brittany Anne, Jennifer M. Rubatt, David L. Corcoran, Deanna K. Teoh, Marcus Q. Bernardini, Lisa A. Grace, William John Soper, et al. “Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines.” Front Oncol 4 (2014): 163. https://doi.org/10.3389/fonc.2014.00163.Full Text Link to Item
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Gauter-Fleckenstein, B., J. S. Reboucas, K. Fleckenstein, A. Tovmasyan, K. Owzar, C. Jiang, I. Batinic-Haberle, and Z. Vujaskovic. “Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+.” Redox Biology 2, no. 1 (January 1, 2014): 400–410. https://doi.org/10.1016/j.redox.2013.12.017.Full Text
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Gauter-Fleckenstein, Benjamin, Julio S. Reboucas, Katharina Fleckenstein, Artak Tovmasyan, Kouros Owzar, Chen Jiang, Ines Batinic-Haberle, and Zeljko Vujaskovic. “Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).” Redox Biol 2 (2014): 400–410. https://doi.org/10.1016/j.redox.2013.12.017.Full Text Link to Item
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Fingerlin, T. E., E. Murphy, W. Zhang, A. L. Peljto, K. K. Brown, M. P. Steele, J. E. Loyd, et al. “Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.” Nat Genet 45, no. 11 (November 2013): 1409. https://doi.org/10.1038/ng1113-1409a.Full Text Link to Item
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Garman, Katherine S., Kouros Owzar, Elizabeth R. Hauser, Kristen Westfall, Blair R. Anderson, Rhonda F. Souza, Anna Mae Diehl, Dawn Provenzale, and Nicholas J. Shaheen. “MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer.” Dig Dis Sci 58, no. 11 (November 2013): 3178–88. https://doi.org/10.1007/s10620-013-2806-7.Full Text Link to Item
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Gupta, Pankaj, Flora Mulkey, Robert P. Hasserjian, Ben L. Sanford, Ravi Vij, David D. Hurd, Olatoyosi M. Odenike, et al. “A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance).” Invest New Drugs 31, no. 5 (October 2013): 1311–20. https://doi.org/10.1007/s10637-013-9978-z.Full Text Link to Item
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DeMatteo, Ronald P., Karla V. Ballman, Cristina R. Antonescu, Christopher Corless, Violetta Kolesnikova, Margaret von Mehren, Martin D. McCarter, et al. “Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor: ACOSOG Z9000 (Alliance) intergroup phase 2 trial.” Ann Surg 258, no. 3 (September 2013): 422–29. https://doi.org/10.1097/SLA.0b013e3182a15eb7.Full Text Link to Item
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Patel, Jai N., Charles S. Fuchs, Kouros Owzar, Zihua Chen, and Howard L. McLeod. “Gastric cancer pharmacogenetics: progress or old tripe?” Pharmacogenomics 14, no. 9 (July 2013): 1053–64. https://doi.org/10.2217/pgs.13.88.Full Text Link to Item
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Kelsey, Chris R., Isabel L. Jackson, Scott Langdon, Kouros Owzar, Jessica Hubbs, Zeljko Vujaskovic, Shiva Das, and Lawrence B. Marks. “Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin.” Clin Lung Cancer 14, no. 3 (May 2013): 267–74. https://doi.org/10.1016/j.cllc.2012.10.006.Full Text Link to Item
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Wheeler, Heather E., Eric R. Gamazon, Claudia Wing, Uchenna O. Njiaju, Chidiamara Njoku, Robert Michael Baldwin, Kouros Owzar, et al. “Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.” Clin Cancer Res 19, no. 2 (January 15, 2013): 491–99. https://doi.org/10.1158/1078-0432.CCR-12-2618.Full Text Link to Item
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Lewis, Lionel D., Antonius A. Miller, Kouros Owzar, Robert R. Bies, Svetlana Markova, Chen Jiang, Deanna L. Kroetz, et al. “The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).” Pharmacogenet Genomics 23, no. 1 (January 2013): 29–33. https://doi.org/10.1097/FPC.0b013e32835b16d8.Full Text Link to Item
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Baldwin, R Michael, Kouros Owzar, Hitoshi Zembutsu, Aparna Chhibber, Michiaki Kubo, Chen Jiang, Dorothy Watson, et al. “A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.” Clin Cancer Res 18, no. 18 (September 15, 2012): 5099–5109. https://doi.org/10.1158/1078-0432.CCR-12-1590.Full Text Link to Item
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Owzar, Kouros, Zhiguo Li, Nancy Cox, and Sin-Ho Jung. “Power and sample size calculations for SNP association studies with censored time-to-event outcomes.” Genet Epidemiol 36, no. 6 (September 2012): 538–48. https://doi.org/10.1002/gepi.21645.Full Text Link to Item
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McCarthy, P. L., K. Owzar, and K. C. Anderson. “Dr. McCarthy and colleagues reply.” New England Journal of Medicine 367, no. 6 (August 9, 2012): 574–75. https://doi.org/10.1056/NEJMc1206734.Full Text
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McCarthy, Philip L., Kouros Owzar, Craig C. Hofmeister, David D. Hurd, Hani Hassoun, Paul G. Richardson, Sergio Giralt, et al. “Lenalidomide after stem-cell transplantation for multiple myeloma.” N Engl J Med 366, no. 19 (May 10, 2012): 1770–81. https://doi.org/10.1056/NEJMoa1114083.Full Text Link to Item
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Kelsey, Chris R., Lauren Jackson, Scott Langdon, Kouros Owzar, Jessica Hubbs, Zeljko Vujaskovic, Shiva Das, and Lawrence B. Marks. “A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint.” Int J Radiat Oncol Biol Phys 82, no. 2 (February 1, 2012): e247–55. https://doi.org/10.1016/j.ijrobp.2011.02.064.Full Text Link to Item
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Innocenti, Federico, Kouros Owzar, Nancy L. Cox, Patrick Evans, Michiaki Kubo, Hitoshi Zembutsu, Chen Jiang, et al. “A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.” Clin Cancer Res 18, no. 2 (January 15, 2012): 577–84. https://doi.org/10.1158/1078-0432.CCR-11-1387.Full Text Link to Item
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Roberts, Andrew S., Michael J. Campa, Elizabeth B. Gottlin, Chen Jiang, Kouros Owzar, Hedy L. Kindler, Alan P. Venook, Richard M. Goldberg, Eileen M. O’Reilly, and Edward F. Patz. “Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303).” Cancer 118, no. 2 (January 15, 2012): 571–78. https://doi.org/10.1002/cncr.26270.Full Text Link to Item
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Owzar, Kouros, William T. Barry, and Sin-Ho Jung. “Statistical considerations for analysis of microarray experiments.” Clin Transl Sci 4, no. 6 (December 2011): 466–77. https://doi.org/10.1111/j.1752-8062.2011.00309.x.Full Text Link to Item
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Lewis, Deborah A., Gregg J. Stashenko, Olga M. Akay, Lulit I. Price, Kouros Owzar, Geoffrey S. Ginsburg, Jen-Tsan Chi, and Thomas L. Ortel. “Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism.” Thromb Res 128, no. 6 (December 2011): 536–40. https://doi.org/10.1016/j.thromres.2011.06.003.Full Text Link to Item
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McCarthy, Philip L., Kouros Owzar, and Kenneth Anderson. “"Sowing dragon's teeth?" Myeloma and AML.” Blood 118, no. 15 (October 13, 2011): 4008–9. https://doi.org/10.1182/blood-2011-08-372243.Full Text Link to Item
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Shea, Thomas, Jeffrey Johnson, Peter Westervelt, Sherif Farag, John McCarty, Asad Bashey, Luis Isola, et al. “Reduced-intensity allogeneic transplantation provides high event-free and overall survival in patients with advanced indolent B cell malignancies: CALGB 109901.” Biol Blood Marrow Transplant 17, no. 9 (September 2011): 1395–1403. https://doi.org/10.1016/j.bbmt.2011.01.016.Full Text Link to Item
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Klymenko, Sergiy V., David A. Belyi, Joel R. Ross, Kouros Owzar, Chen Jiang, Zhiguo Li, Janna N Minchenko, Aleksandr N Kovalenko, Volodymyr G. Bebeshko, and Nelson J Chao. “Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident.” Int J Radiat Biol 87, no. 8 (August 2011): 846–50. https://doi.org/10.3109/09553002.2011.560995.Full Text Link to Item
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Sohn, Insuk, Kouros Owzar, Johan Lim, Stephen L. George, Stephanie Mackey Cushman, and Sin-Ho Jung. “Multiple testing for gene sets from microarray experiments.” Bmc Bioinformatics 12 (May 26, 2011): 209. https://doi.org/10.1186/1471-2105-12-209.Full Text Open Access Copy Link to Item
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Frahm, Marc, Neela D. Goswami, Kouros Owzar, Emily Hecker, Ann Mosher, Emily Cadogan, Payam Nahid, Guido Ferrari, and Jason E. Stout. “Discriminating between latent and active tuberculosis with multiple biomarker responses.” Tuberculosis (Edinb) 91, no. 3 (May 2011): 250–56. https://doi.org/10.1016/j.tube.2011.02.006.Full Text Link to Item
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Bashey, Asad, Kouros Owzar, Jeffrey L. Johnson, Peggy S. Edwards, Michael Kelly, Lee-Ann Baxter-Lowe, Steven Devine, et al. “Reduced-intensity conditioning allogeneic hematopoietic cell transplantation for patients with hematologic malignancies who relapse following autologous transplantation: a multi-institutional prospective study from the Cancer and Leukemia Group B (CALGB trial 100002).” Biol Blood Marrow Transplant 17, no. 4 (April 2011): 558–65. https://doi.org/10.1016/j.bbmt.2010.07.015.Full Text Link to Item
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Mitha, Faheem, Herodotos Herodotou, Nedyalko Borisov, Chen Jiang, Josh Yoder, and Kouros Owzar. “SNPpy--database management for SNP data from genome wide association studies.” Plos One 6, no. 10 (2011): e24982. https://doi.org/10.1371/journal.pone.0024982.Full Text Open Access Copy Link to Item
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Sohn, Insuk, Kouros Owzar, Stephen L. George, Sujong Kim, and Sin-Ho Jung. “Robust test method for time-course microarray experiments.” Bmc Bioinformatics 11 (July 22, 2010): 391. https://doi.org/10.1186/1471-2105-11-391.Full Text Open Access Copy Link to Item
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Shterev, Ivo D., Sin-Ho Jung, Stephen L. George, and Kouros Owzar. “permGPU: Using graphics processing units in RNA microarray association studies.” Bmc Bioinformatics 11 (June 16, 2010): 329. https://doi.org/10.1186/1471-2105-11-329.Full Text Open Access Copy Link to Item
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Chen, Benny J., Divino Deoliveira, Ivan Spasojevic, Gregory D. Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, et al. “Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.” Plos One 5, no. 6 (June 16, 2010): e11056. https://doi.org/10.1371/journal.pone.0011056.Full Text Open Access Copy Link to Item
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Gauter-Fleckenstein, Benjamin, Katharina Fleckenstein, Kouros Owzar, Chen Jiang, Júlio S. Rebouças, Ines Batinic-Haberle, and Zeljko Vujaskovic. “Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage.” Free Radic Biol Med 48, no. 8 (April 15, 2010): 1034–43. https://doi.org/10.1016/j.freeradbiomed.2010.01.020.Full Text Link to Item
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Halabi, Susan, and Kouros Owzar. “The importance of identifying and validating prognostic factors in oncology.” Semin Oncol 37, no. 2 (April 2010): e9-18. https://doi.org/10.1053/j.seminoncol.2010.04.001.Full Text Link to Item
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Civantos, Francisco J., Robert P. Zitsch, David E. Schuller, Amit Agrawal, Russell B. Smith, Richard Nason, Guy Petruzelli, et al. “Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial.” J Clin Oncol 28, no. 8 (March 10, 2010): 1395–1400. https://doi.org/10.1200/JCO.2008.20.8777.Full Text Link to Item
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Sohn, Insuk, Kouros Owzar, Stephen L. George, Sujong Kim, and Sin-Ho Jung. “A permutation-based multiple testing method for time-course microarray experiments.” Bmc Bioinformatics 10 (October 15, 2009): 336. https://doi.org/10.1186/1471-2105-10-336.Full Text Link to Item
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Linker, C. A., K. Owzar, B. Powell, D. Hurd, L. E. Damon, L. E. Archer, R. A. Larson, and R. A. Cancer and Leukemia Group B. “Auto-SCT for AML in second remission: CALGB study 9620.” Bone Marrow Transplant 44, no. 6 (September 2009): 353–59. https://doi.org/10.1038/bmt.2009.36.Full Text Link to Item
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Halabi, Susan, Nicholas J. Vogelzang, San-San Ou, Kouros Owzar, Laura Archer, and Eric J. Small. “Progression-free survival as a predictor of overall survival in men with castrate-resistant prostate cancer.” J Clin Oncol 27, no. 17 (June 10, 2009): 2766–71. https://doi.org/10.1200/JCO.2008.18.9159.Full Text Link to Item
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Lambotte, Olivier, Guido Ferrari, Christiane Moog, Nicole L. Yates, Hua-Xin Liao, Robert J. Parks, Charles B. Hicks, et al. “Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers.” Aids 23, no. 8 (May 15, 2009): 897–906. https://doi.org/10.1097/QAD.0b013e328329f97d.Full Text Link to Item
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Miller, Antonius A., Daryl J. Murry, Kouros Owzar, Donna R. Hollis, Erin B. Kennedy, Ghassan Abou-Alfa, Apurva Desai, et al. “Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301.” J Clin Oncol 27, no. 11 (April 10, 2009): 1800–1805. https://doi.org/10.1200/JCO.2008.20.0931.Full Text Link to Item
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Dematteo, Ronald P., Karla V. Ballman, Cristina R. Antonescu, Robert G. Maki, Peter W. T. Pisters, George D. Demetri, Martin E. Blackstein, et al. “Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial.” Lancet 373, no. 9669 (March 28, 2009): 1097–1104. https://doi.org/10.1016/S0140-6736(09)60500-6.Full Text Link to Item
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Demark-Wahnefried, Wendy, Thomas J. Polascik, Stephen L. George, Boyd R. Switzer, John F. Madden, Mack T. Ruffin, Denise C. Snyder, et al. “Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.” Cancer Epidemiol Biomarkers Prev 17, no. 12 (December 2008): 3577–87. https://doi.org/10.1158/1055-9965.EPI-08-0008.Full Text Link to Item
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Owzar, K., and S. H. Jung. “Authors' response.” Clinical Trials 5, no. 3 (December 1, 2008): 223–24. https://doi.org/10.1177/17407745080050031102.Full Text
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Heinrich, Michael C., Kouros Owzar, Christopher L. Corless, Donna Hollis, Ernest C. Borden, Christopher D. M. Fletcher, Christopher W. Ryan, et al. “Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.” J Clin Oncol 26, no. 33 (November 20, 2008): 5360–67. https://doi.org/10.1200/JCO.2008.17.4284.Full Text Link to Item
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Owzar, Kouros, William T. Barry, Sin-Ho Jung, Insuk Sohn, and Stephen L. George. “Statistical challenges in preprocessing in microarray experiments in cancer.” Clin Cancer Res 14, no. 19 (October 1, 2008): 5959–66. https://doi.org/10.1158/1078-0432.CCR-07-4532.Full Text Link to Item
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Owzar, Kouros. “Alternate statistical tools and limitations in genetic marker association studies in single-arm drug cancer trials.” J Clin Oncol 26, no. 9 (March 20, 2008): 1400–1401. https://doi.org/10.1200/JCO.2007.14.7306.Full Text Link to Item
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Gauter-Fleckenstein, Benjamin, Katharina Fleckenstein, Kouros Owzar, Chen Jiang, Ines Batinic-Haberle, and Zeljko Vujaskovic. “Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.” Free Radic Biol Med 44, no. 6 (March 15, 2008): 982–89. https://doi.org/10.1016/j.freeradbiomed.2007.10.058.Full Text Link to Item
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Owzar, Kouros, and Sin-Ho Jung. “Designing phase II studies in cancer with time-to-event endpoints.” Clin Trials 5, no. 3 (2008): 209–21. https://doi.org/10.1177/1740774508091748.Full Text Link to Item
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Owzar, Kouros, Sin-Ho Jung, and Pranab Kumar Sen. “A copula approach for detecting prognostic genes associated with survival outcome in microarray studies.” Biometrics 63, no. 4 (December 2007): 1089–98. https://doi.org/10.1111/j.1541-0420.2007.00802.x.Full Text Link to Item
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Miller, Antonius A., Daryl J. Murry, Kouros Owzar, Donna R. Hollis, Lionel D. Lewis, Hedy L. Kindler, John L. Marshall, et al. “Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101.” J Clin Oncol 25, no. 21 (July 20, 2007): 3055–60. https://doi.org/10.1200/JCO.2007.11.6210.Full Text Link to Item
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Jung, S. H., K. Owzar, S. L. George, and T. Lee. “Rejoinder.” Journal of Biopharmaceutical Statistics 16, no. 6 (December 1, 2006): 781–83. https://doi.org/10.1080/10543400600954452.Full Text
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Sicklick, Jason K., Yin-Xiong Li, Aruna Jayaraman, Rajesh Kannangai, Yi Qi, Perumal Vivekanandan, John W. Ludlow, et al. “Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.” Carcinogenesis 27, no. 4 (April 2006): 748–57. https://doi.org/10.1093/carcin/bgi292.Full Text Link to Item
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Jung, Sin-Ho, Kouros Owzar, Stephen L. George, and Taiyeong Lee. “P-value calculation for multistage phase II cancer clinical trials.” J Biopharm Stat 16, no. 6 (2006): 765–75. https://doi.org/10.1080/10543400600825645.Full Text Link to Item
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Roalf, David R., Bruce I. Turetsky, Kiana Owzar, Catherine C. Balderston, Sarah C. Johnson, Colleen M. Brensinger, Raquel E. Gur, Steven J. Siegel, and Paul J. Moberg. “Unirhinal olfactory function in schizophrenia patients and first-degree relatives.” J Neuropsychiatry Clin Neurosci 18, no. 3 (2006): 389–96. https://doi.org/10.1176/jnp.2006.18.3.389.Full Text Link to Item
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Jung, Sin-Ho, Kouros Owzar, and Stephen L. George. “A multiple testing procedure to associate gene expression levels with survival.” Stat Med 24, no. 20 (October 30, 2005): 3077–88. https://doi.org/10.1002/sim.2179.Full Text Link to Item
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Skinner, Michael A., Jeffrey A. Moley, William G. Dilley, Kouros Owzar, Mary K. Debenedetti, and Samuel A. Wells. “Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A.” N Engl J Med 353, no. 11 (September 15, 2005): 1105–13. https://doi.org/10.1056/NEJMoa043999.Full Text Link to Item
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Owzar, K., and P. K. Sen. “Copulas: Concepts and novel applications.” Metron 61, no. 3 (December 1, 2003): 323–53.
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Turetsky, Bruce I., Paul J. Moberg, Kiana Owzar, Sarah C. Johnson, Richard L. Doty, and Raquel E. Gur. “Physiologic impairment of olfactory stimulus processing in schizophrenia.” Biol Psychiatry 53, no. 5 (March 1, 2003): 403–11. https://doi.org/10.1016/s0006-3223(02)01865-6.Full Text Link to Item
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Conference Papers
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Patierno, Brendon M., Wen-Chi Foo, Tyler Allen, Jason A. Somarelli, Kathryn E. Ware, Santosh Gupta, Sandra Wise, et al. “Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.” In Prostate Cancer Prostatic Dis, 25:513–23, 2022. https://doi.org/10.1038/s41391-021-00460-y.Full Text Open Access Copy Link to Item
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Innocenti, F., C. Jiang, A. B. Sibley, S. Denning, A. S. Etheridge, D. Watson, D. Niedzwiecki, et al. “A genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients.” In Ann Oncol, 29 Suppl 8:viii661–62, 2018. https://doi.org/10.1093/annonc/mdy303.038.Full Text Link to Item
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Bahmani, A., A. B. Sibley, M. Parsian, K. Owzar, and F. Mueller. “SparkScore: Leveraging apache spark for distributed genomic inference.” In Proceedings 2016 Ieee 30th International Parallel and Distributed Processing Symposium, Ipdps 2016, 435–42, 2016. https://doi.org/10.1109/IPDPSW.2016.6.Full Text
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Wang, Xiaofeng, Kouros Owzar, Pankaj Gupta, Richard A. Larson, Flora Mulkey, Antonius A. Miller, Lionel D. Lewis, et al. “Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome: CALGB 10105 (Alliance).” In Br J Clin Pharmacol, 78:1005–13, 2014. https://doi.org/10.1111/bcp.12427.Full Text Link to Item
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- Teaching & Mentoring
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Advising & Mentoring
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Master of Biostatistics, Duke University
- Li Liu MB Committee, Duke Biostatistics (2018-Present)
- Qi Gao MB Committee, Duke Biostatistics (2017-2018; joined PhD program of Biostatistics at Duke in Fall 2018)
- Xi Wang MB Committee, Duke Biostatistics (2017-2018; joined PhD program of Biostatistics at Penn State in Fall 2018)
- Yang Ou MB Committee, Duke Biostatistics (2017-2018; joined PhD program of Biostatistics at University of Pittsburg in Fall 2018)
- Tianhui Zhou MB Committee, Duke Biostatistics (2017-2018; joined PhD program of Biostatistics at Duke in Fall 2017)
- Beilin Jia MB Committee, Duke Biostatistics (2016-2017; joined PhD program of Biostatistics at University of North Carolina at Chapel Hill in Fall 2017)
- Kirsten Bell MB Committee, Duke Biostatistics (2016-2017; joined Northwestern University as Biostatistician in 2018)
- Xuechan Li MB Committee, Duke Biostatistics (2014-2016; joined PhD program in Biostatistics at Duke in Fall 2017)
- Tracy Truong, MB Committee, Duke Biostatistics (2013-2014; joined Duke Biostatistics Core in 2014)
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Master of Biostatistics, Duke University
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Teaching Activities
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BIOSTAT 905, Spring 2017, 2018, 2019
BIOSTAT 824, Spring 2019
BIOSTAT 704, Spring 2012, 2013, 2014, 2016
BIOSTAT 707, Fall 2012, 2013, 2014, 2015
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BIOSTAT 905, Spring 2017, 2018, 2019
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