Skip to main content

Michael S. Krangel

George Barth Geller Distinguished Professor of Immunology
Integrative Immunobiology
Duke Box 3010, Durham, NC 27710
318 Jones Bldg, Durham, NC 27710

Scholarly Works - Book sections


Organization and Rearrangement of TCR loci

Book section · January 1, 2025 The adaptive immune response in vertebrates relies on the expression of antigen-specific receptors on lymphocytes to recognize a myriad of different molecules produced by pathogens and cancer cells. The antigen T-cell receptor (TCR) genes are organized in ... Full text Cite

Allelic Exclusion, Isotypic Exclusion, and the Developmental Regulation of V(D)J Recombination

Book section · January 1, 2004 This chapter focuses on the various mechanisms that impart developmental control to V(D)J recombination and that yield allelically and isotypically excluded antigen receptor repertoires. The lymphoid specificity of V(D)J recombination reflects the regulate ... Full text Cite