Kris Cameron Wood | Scholars@Duke

Kris Cameron Wood
Assistant Professor of Pharmacology & Cancer Biology

Current Appointments & Affiliations

Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012
Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018

Contact Information

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2007
- B.S., University of Kentucky at Lexington 2002
Duke Appointment History
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016 - 2019
Recognition
In the News
- OCT 3, 2018 Duke Med Alumni News
  
  From Innovation to Impact
- APR 9, 2018
  
  Faculty Startup Sold to Belgian Pharma for $30 Million
- OCT 25, 2017 Duke Cancer Institute
  
  Why Do Perfectly Good Cancer Treatments Suddenly Stop Working?
- NOV 19, 2015 Duke Research Blog
  
  The Challenges of Combating Cancer Drug Resistance
- JAN 5, 2015
  
  Researchers Map Paths to Cancer Drug Resistance
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- Computational Structure-Based Protein Design Non-competing Renewal (Yr. 10) awarded by National Institutes of Health 2008 - 2022
- Selectively targeting apoptosis in PIK3CA mutant colorectal cancers awarded by National Institutes of Health 2016 - 2021
- Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance awarded by National Institutes of Health 2017 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- High-throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity awarded by Celldom 2018 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Topological Methods for Morphology: Classifying Shape and Function via Dictionary Learning awarded by Columbia University 2016 - 2020
- Single cell functional dissection of tumor microenviornment-driven drug resistance awarded by National Institutes of Health 2018 - 2020
- Precision targeting of altered mitochondrial states in ovarian cancer awarded by Ovarian Cancer Research Fund, Inc. 2015 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Targeting the Hippo pathway in Ras-driven rhabdomyosarcoma awarded by V Foundation for Cancer Research 2016 - 2019
- Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
- Identification and validation of the PAX3-FOXO1 protein interactome awarded by St. Baldrick's Foundation 2018 - 2019
- Identification of synthetic lethal interactors in pancreatic cancer awarded by University of North Carolina - Chapel Hill 2015 - 2019
- Exploring BCL-XL addiction in pancreatic ductal adenocarcinoma awarded by National Institutes of Health 2016 - 2019
- RalA signal transduction awarded by National Institutes of Health 2002 - 2019
- Copy Number Alterations in Low Mutation Cancer awarded by National Institutes of Health 2018 - 2019
- Exploiting collateral sensitivity to target kinase inhibitor-resistant lung cancers awarded by Burroughs Wellcome Fund 2017 - 2018
- Unmasking targetable dependencies in cancer with intrinsic or acquired resistance to anti-cancer therapies awarded by National Institutes of Health 2017 - 2018
- Integration of signaling and metabolic pathways in the regulation of EMT awarded by US-Israel Binational Science Foundation 2016 - 2018
- Profiling Gene Interactions in the Human Kinome awarded by National Science Foundation 2015 - 2018
- Targeting undruggable oncogenes through the epigenome awarded by Element Genomics, Inc. 2017 - 2018
- Designing durable apoptosis-targeting therapies for acute myeloid leukemia awarded by National Institutes of Health 2016 - 2018
- Mapping the landscape of drug sensitizers in human cancers awarded by National Institutes of Health 2015 - 2017
- Genomic and Computational Approaches for Development of Novel Anticancer Therapies awarded by Schlumberger Foundation 2015 - 2017
- Systematic design of CDK4/6 inhibitor-based combination therapies awarded by G1 Therapeutics Inc. 2015 - 2016
- A Platform for Real-time Drug Profiling of Patient-Derived Melanomas awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Systematic dissection of the breast cancer microenvironment using the MicroSCALE Toolkit awarded by V Foundation for Cancer Research 2013 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lin, KH, Xie, A, Rutter, JC, Ahn, Y-R, Lloyd-Cowden, JM, Nichols, AG, Soderquist, RS, Koves, TR, Muoio, DM, MacIver, NJ, Lamba, JK, Pardee, TS, McCall, CM, Rizzieri, DA, and Wood, KC. "Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity." Cell Metabolism (February 5, 2019). Full Text
  - Ding, Y, Gong, C, Huang, D, Chen, R, Sui, P, Lin, KH, Liang, G, Yuan, L, Xiang, H, Chen, J, Yin, T, Alexander, PB, Wang, Q-F, Song, E-W, Li, Q-J, Wood, KC, and Wang, X-F. "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers." Nature Communications 9, no. 1 (October 15, 2018): 4274-null. Full Text
  - Soderquist, RS, Crawford, L, Liu, E, Lu, M, Agarwal, A, Anderson, GR, Lin, KH, Winter, PS, Cakir, M, and Wood, KC. "Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity." Nature Communications 9, no. 1 (August 29, 2018): 3513-null. Full Text
  - Ohiri, KA, Kelly, ST, Motschman, JD, Lin, KH, Wood, KC, and Yellen, BB. "An acoustofluidic trap and transfer approach for organizing a high density single cell array." Lab on a Chip 18, no. 14 (July 2018): 2124-2133. Full Text Open Access Copy
  - Winter, PS, and Wood, KC. "Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers." Trends in Cancer 4, no. 5 (May 2018): 333-335. Full Text
  - Anderson, GR, Wardell, SE, Cakir, M, Yip, C, Ahn, Y-R, Ali, M, Yllanes, AP, Chao, CA, McDonnell, DP, and Wood, KC. "Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors." Nature Communications 9, no. 1 (April 26, 2018): 1677-null. Full Text
  - Crawford, L, Wood, KC, Zhou, X, and Mukherjee, S. "Bayesian Approximate Kernel Regression with Variable Selection." Journal of the American Statistical Association 113, no. 524 (January 2018): 1710-1721. Full Text
  - Singleton, KR, Crawford, L, Tsui, E, Manchester, HE, Maertens, O, Liu, X, Liberti, MV, Magpusao, AN, Stein, EM, Tingley, JP, Frederick, DT, Boland, GM, Flaherty, KT, McCall, SJ, Krepler, C, Sproesser, K, Herlyn, M, Adams, DJ, Locasale, JW, Cichowski, K, Mukherjee, S, and Wood, KC. "Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence." Cell Reports 21, no. 10 (December 2017): 2796-2812. Full Text
  - Anderson, GR, Winter, PS, Lin, KH, Nussbaum, DP, Cakir, M, Stein, EM, Soderquist, RS, Crawford, L, Leeds, JC, Newcomb, R, Stepp, P, Yip, C, Wardell, SE, Tingley, JP, Ali, M, Xu, M, Ryan, M, McCall, SJ, McRee, AJ, Counter, CM, Der, CJ, and Wood, KC. "A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution." Cell Reports 20, no. 4 (July 2017): 999-1015. Full Text
  - Ali, M, Kaltenbrun, E, Anderson, GR, Stephens, SJ, Arena, S, Bardelli, A, Counter, CM, and Wood, KC. "Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance." Nature Communications 8 (June 8, 2017): 15617-null. Full Text
  - Price, AM, Dai, J, Bazot, Q, Patel, L, Nikitin, PA, Djavadian, R, Winter, PS, Salinas, CA, Barry, AP, Wood, KC, Johannsen, EC, Letai, A, Allday, MJ, and Luftig, MA. "Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection." Elife 6 (April 20, 2017). Full Text Open Access Copy
  - Wood, KC. "Suppressing oncogenic transcription with a little healthy competition." Science Translational Medicine 9, no. 374 (January 2017). Full Text
  - Anderson, GR, Wardell, SE, Cakir, M, Crawford, L, Leeds, JC, Nussbaum, DP, Shankar, PS, Soderquist, RS, Stein, EM, Tingley, JP, Winter, PS, Zieser-Misenheimer, EK, Alley, HM, Yllanes, A, Haney, V, Blackwell, KL, McCall, SJ, McDonnell, DP, and Wood, KC. "PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation." Science Translational Medicine 8, no. 369 (December 2016): 369ra175-null. Full Text Open Access Copy
  - Wood, KC. "An EXITS strategy for decreasing cancer risk in women." Science translational medicine 8, no. 368 (December 2016): 368ec197-. Full Text
  - Wood, KC. "Hacking T cells with synthetic circuits to program antitumor responses." Science Translational Medicine 8, no. 362 (October 26, 2016). Full Text
  - Wood, KC. "Two faces of circulating breast cancer cells." Science Translational Medicine 8, no. 356 (September 14, 2016). Full Text
  - Wood, KC. "Mapping a path for precision cancer therapies." Science Translational Medicine 8, no. 348 (July 20, 2016): 348ec115-348ec115. Full Text
  - Singleton, KR, and Wood, KC. "Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes." Genes & cancer 7, no. 7-8 (July 2016): 218-228. (Review) Full Text Open Access Copy
  - Wood, KC. "Targeting the cancer cells that just won't go away." Science Translational Medicine 8, no. 344 (June 22, 2016). Full Text
  - Lin, KH, Winter, PS, Xie, A, Roth, C, Martz, CA, Stein, EM, Anderson, GR, Tingley, JP, and Wood, KC. "Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia." Scientific Reports 6 (June 10, 2016): 27696-null. Full Text
  - Cribb, JA, Osborne, LD, Beicker, K, Psioda, M, Chen, J, O'Brien, ET, Taylor Ii, RM, Vicci, L, Hsiao, JP-L, Shao, C, Falvo, M, Ibrahim, JG, Wood, KC, Blobe, GC, and Superfine, R. "An Automated High-throughput Array Microscope for Cancer Cell Mechanics." Scientific Reports 6 (June 6, 2016): 27371-null. Full Text
  - Wood, KC. "Collaborating tumor cells overcome multitargeted antiangiogenic therapies." Science Translational Medicine 8, no. 338 (May 11, 2016). Full Text
  - Park, S, Chang, C-Y, Safi, R, Liu, X, Baldi, R, Jasper, JS, Anderson, GR, Liu, T, Rathmell, JC, Dewhirst, MW, Wood, KC, Locasale, JW, and McDonnell, DP. "ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer." Cell Reports 15, no. 2 (April 2016): 323-335. Full Text
  - Wood, KC. "Intercepting reversible drug tolerance to improve targeted therapy." Science Translational Medicine 8, no. 332 (March 30, 2016): 332ec52-332ec52. Full Text
  - Son, S, Stevens, MM, Chao, HX, Thoreen, C, Hosios, AM, Schweitzer, LD, Weng, Y, Wood, K, Sabatini, D, Vander Heiden, MG, and Manalis, S. "Cooperative nutrient accumulation sustains growth of mammalian cells." Scientific reports 5 (December 2015): 17401-. Full Text
  - Wood, KC. "Mapping the Pathways of Resistance to Targeted Therapies." Cancer research 75, no. 20 (October 2015): 4247-4251. (Review) Full Text
  - Misale, S, Bozic, I, Tong, J, Peraza-Penton, A, Lallo, A, Baldi, F, Lin, KH, Truini, M, Trusolino, L, Bertotti, A, Di Nicolantonio, F, Nowak, MA, Zhang, L, Wood, KC, and Bardelli, A. "Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers." Nature Communications 6 (September 22, 2015): 8305-null. Full Text
  - Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of Clinical Investigation 125, no. 1 (January 2015): 194-207. Full Text Open Access Copy
  - Martz, CA, Ottina, KA, Singleton, KR, Jasper, JS, Wardell, SE, Peraza-Penton, A, Anderson, GR, Winter, PS, Wang, T, Alley, HM, Kwong, LN, Cooper, ZA, Tetzlaff, M, Chen, P-L, Rathmell, JC, Flaherty, KT, Wargo, JA, McDonnell, DP, Sabatini, DM, and Wood, KC. "Systematic identification of signaling pathways with potential to confer anticancer drug resistance." Science Signaling 7, no. 357 (December 23, 2014): ra121-null. Full Text
  - Winter, PS, Sarosiek, KA, Lin, KH, Meggendorfer, M, Schnittger, S, Letai, A, and Wood, KC. "RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis." Science Signaling 7, no. 357 (December 23, 2014): ra122-null. Full Text
  - Wood, KB, Wood, KC, Nishida, S, and Cluzel, P. "Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells." Cell Reports 6, no. 6 (March 6, 2014): 1073-1084. Full Text
  - Wood, KC, and VanHook, AM. "Science signaling podcast: 23 December 2014." Science Signaling 7, no. 357 (January 1, 2014). (Review) Full Text
  - Wood, KC, Konieczkowski, DJ, Johannessen, CM, Boehm, JS, Tamayo, P, Botvinnik, OB, Mesirov, JP, Hahn, WC, Root, DE, Garraway, LA, and Sabatini, DM. "MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma." Science Signaling 5, no. 224 (May 15, 2012): rs4-null. Full Text
  - Wood, KC, and Sabatini, DM. "Growth Signaling at the Nexus of Stem Cell Life and Death." Cell Stem Cell 5, no. 3 (2009): 232-234. Full Text
  - Wood, KC, Azarin, SM, Arap, W, Pasqualini, R, Langer, R, and Hammond, PT. "Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide." Bioconjugate Chemistry 19, no. 2 (2008): 403-405. Full Text
  - Wood, KC, Zacharia, NS, Schmidt, DJ, Wrightman, SN, Andaya, BJ, and Hammond, PT. "Electroactive controlled release thin films." Proceedings of the National Academy of Sciences of the United States of America 105, no. 7 (2008): 2280-2285. Full Text
  - Wood, KC, Chuang, HF, Batten, RD, Lynn, DM, and Hammond, PT. "Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films." Proceedings of the National Academy of Sciences of the United States of America 103, no. 27 (July 4, 2006): 10207-10212. Full Text
  - Wood, KC, Boedicker, JQ, Lynn, DM, and Hammond, PT. "Tunable drug release from hydrolytically degradable layer-by-layer thin films." Langmuir 21, no. 4 (February 15, 2005): 1603-1609. Full Text
  - Wood, KC, Little, SR, Langer, R, and Hammond, PT. "A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery." Angewandte Chemie - International Edition 44, no. 41 (2005): 6704-6708. Full Text
  - Meyer, DE, Wood, K, Bachas, LG, and Bhattacharyya, D. "Degradation of chlorinated organics by membrane-immobilized nanosized metals." Environmental Progress 23, no. 3 (October 1, 2004): 232-242. Full Text
- Conference Papers
  - Wood, KC. "Leveraging Synthetic Lethality to Target Convergent Therapeutic Resistance." Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting. Chicago, IL. April 22, 2017 - April 26, 2017.: FEDERATION AMER SOC EXP BIOL, April 1, 2017. Link to Item
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses