Kris Cameron Wood | Scholars@Duke

Kris Cameron Wood
Assistant Professor of Pharmacology & Cancer Biology

Current Appointments & Affiliations

Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012

Contact Information

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2007
- B.S., University of Kentucky at Lexington 2002
Recognition
In the News
- NOV 19, 2015 Duke Research Blog
  
  The Challenges of Combating Cancer Drug Resistance
- JAN 5, 2015
  
  Researchers Map Paths to Cancer Drug Resistance
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Selectively targeting apoptosis in PIK3CA mutant colorectal cancers awarded by National Institutes of Health 2016 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Topological Methods for Morphology: Classifying Shape and Function via Dictionary Learning awarded by Columbia University 2016 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
- Exploring BCL-XL addiction in pancreatic ductal adenocarcinoma awarded by National Institutes of Health 2016 - 2019
- Integration of signaling and metabolic pathways in the regulation of EMT awarded by US-Israel Binational Science Foundation 2016 - 2018
- Profiling Gene Interactions in the Human Kinome awarded by National Science Foundation 2015 - 2018
- Targeting undruggable oncogenes through the epigenome awarded by Element Genomics, Inc. 2017 - 2018
- Designing durable apoptosis-targeting therapies for acute myeloid leukemia awarded by National Institutes of Health 2016 - 2018
- Mapping the landscape of drug sensitizers in human cancers awarded by National Institutes of Health 2015 - 2018
- Defining new combination therapies for high-grade serous ovarian cancer awarded by Ovarian Cancer Research Fund, Inc. 2015 - 2018
- Genomic and Computational Approaches for Development of Novel Anticancer Therapies awarded by Schlumberger Foundation 2015 - 2017
- Identification of synthetic lethal interactors in pancreatic cancer awarded by University of North Carolina - Chapel Hill 2015 - 2017
- Systematic design of CDK4/6 inhibitor-based combination therapies awarded by G1 Therapeutics Inc. 2015 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Systematic dissection of the breast cancer microenvironment using the MicroSCALE Toolkit awarded by V Foundation for Cancer Research 2013 - 2015
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Anderson, GR, Winter, PS, Lin, KH, Nussbaum, DP, Cakir, M, Stein, EM, Soderquist, RS, Crawford, L, Leeds, JC, Newcomb, R, Stepp, P, Yip, C, Wardell, SE, Tingley, JP, Ali, M, Xu, M, Ryan, M, McCall, SJ, McRee, AJ, Counter, CM, Der, CJ, and Wood, KC. "A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution." Cell reports 20, no. 4 (July 2017): 999-1015. Full Text
  - Ali, M, Kaltenbrun, E, Anderson, GR, Stephens, SJ, Arena, S, Bardelli, A, Counter, CM, and Wood, KC. "Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance." Nature communications 8 (June 8, 2017): 15617-. Full Text
  - Price, AM, Dai, J, Bazot, Q, Patel, L, Nikitin, PA, Djavadian, R, Winter, PS, Salinas, CA, Barry, AP, Wood, KC, Johannsen, EC, Letai, A, Allday, MJ, and Luftig, MA. "Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection." eLife 6 (April 20, 2017). Full Text Open Access Copy
  - Wood, KC. "Suppressing oncogenic transcription with a little healthy competition." Science translational medicine 9, no. 374 (January 2017). Full Text
  - Anderson, GR, Wardell, SE, Cakir, M, Crawford, L, Leeds, JC, Nussbaum, DP, Shankar, PS, Soderquist, RS, Stein, EM, Tingley, JP, Winter, PS, Zieser-Misenheimer, EK, Alley, HM, Yllanes, A, Haney, V, Blackwell, KL, McCall, SJ, McDonnell, DP, and Wood, KC. "PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation." Science translational medicine 8, no. 369 (December 2016): 369ra175-. Full Text Open Access Copy
  - Wood, KC. "An EXITS strategy for decreasing cancer risk in women." Science translational medicine 8, no. 368 (December 2016): 368ec197-. Full Text
  - Wood, KC. "Hacking T cells with synthetic circuits to program antitumor responses." Science Translational Medicine 8, no. 362 (October 26, 2016): 362ec172-362ec172. Full Text
  - Wood, KC. "Mapping a path for precision cancer therapies." Science Translational Medicine 8, no. 348 (July 20, 2016): 348ec115-348ec115. Full Text
  - Singleton, KR, and Wood, KC. "Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes." Genes & cancer 7, no. 7-8 (July 2016): 218-228. (Review) Open Access Copy
  - Wood, KC. "Targeting the cancer cells that just wont go away." Science Translational Medicine 8, no. 344 (June 22, 2016): 344ec101-344ec101. Full Text
  - Lin, KH, Winter, PS, Xie, A, Roth, C, Martz, CA, Stein, EM, Anderson, GR, Tingley, JP, and Wood, KC. "Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia." Scientific Reports 6 (June 10, 2016): 27696-. Full Text
  - Cribb, JA, Osborne, LD, Beicker, K, Psioda, M, Chen, J, O'Brien, ET, Taylor Ii, RM, Vicci, L, Hsiao, JP-L, Shao, C, Falvo, M, Ibrahim, JG, Wood, KC, Blobe, GC, and Superfine, R. "An Automated High-throughput Array Microscope for Cancer Cell Mechanics." Scientific Reports 6 (June 6, 2016): 27371-. Full Text
  - Wood, KC. "Collaborating tumor cells overcome multitargeted antiangiogenic therapies." Science Translational Medicine 8, no. 338 (May 11, 2016).
  - Park, S, Chang, C-Y, Safi, R, Liu, X, Baldi, R, Jasper, JS, Anderson, GR, Liu, T, Rathmell, JC, Dewhirst, MW, Wood, KC, Locasale, JW, and McDonnell, DP. "ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer." Cell reports 15, no. 2 (April 2016): 323-335. Full Text
  - Wood, KC. "Intercepting reversible drug tolerance to improve targeted therapy." Science Translational Medicine 8, no. 332 (March 30, 2016): 332ec52-332ec52. Full Text
  - Wood, KC. "Mapping the Pathways of Resistance to Targeted Therapies." Cancer research 75, no. 20 (October 2015): 4247-4251. (Review) Full Text
  - Misale, S, Bozic, I, Tong, J, Peraza-Penton, A, Lallo, A, Baldi, F, Lin, KH, Truini, M, Trusolino, L, Bertotti, A, Di Nicolantonio, F, Nowak, MA, Zhang, L, Wood, KC, and Bardelli, A. "Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers." Nature communications 6 (September 22, 2015): 8305-. Full Text
  - Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of clinical investigation 125, no. 1 (January 2015): 194-207. Full Text Open Access Copy
  - Martz, CA, Ottina, KA, Singleton, KR, Jasper, JS, Wardell, SE, Peraza-Penton, A, Anderson, GR, Winter, PS, Wang, T, Alley, HM, Kwong, LN, Cooper, ZA, Tetzlaff, M, Chen, P-L, Rathmell, JC, Flaherty, KT, Wargo, JA, McDonnell, DP, Sabatini, DM, and Wood, KC. "Systematic identification of signaling pathways with potential to confer anticancer drug resistance." Science signaling 7, no. 357 (December 23, 2014): ra121-. Full Text
  - Winter, PS, Sarosiek, KA, Lin, KH, Meggendorfer, M, Schnittger, S, Letai, A, and Wood, KC. "RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis." Science signaling 7, no. 357 (December 23, 2014): ra122-. Full Text
  - Wood, KC, and VanHook, AM. "Science Signaling Podcast: 23 December 2014." Science Signaling 7, no. 357 (December 23, 2014): pc33-pc33. Full Text
  - Wood, KB, Wood, KC, Nishida, S, and Cluzel, P. "Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells." Cell reports 6, no. 6 (March 6, 2014): 1073-1084. Full Text
  - Wood, KC, Konieczkowski, DJ, Johannessen, CM, Boehm, JS, Tamayo, P, Botvinnik, OB, Mesirov, JP, Hahn, WC, Root, DE, Garraway, LA, and Sabatini, DM. "MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma." Science Signaling 5, no. 224 (2012). Full Text
  - Wood, KC, and Sabatini, DM. "Growth Signaling at the Nexus of Stem Cell Life and Death." Cell Stem Cell 5, no. 3 (2009): 232-234. Full Text
  - Wood, KC, Azarin, SM, Arap, W, Pasqualini, R, Langer, R, and Hammond, PT. "Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide." Bioconjugate Chemistry 19, no. 2 (2008): 403-405. Full Text
  - Wood, KC, Zacharia, NS, Schmidt, DJ, Wrightman, SN, Andaya, BJ, and Hammond, PT. "Electroactive controlled release thin films." Proceedings of the National Academy of Sciences of the United States of America 105, no. 7 (2008): 2280-2285. Full Text
  - Wood, KC, Chuang, HF, Batten, RD, Lynn, DM, and Hammond, PT. "Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films." Proceedings of the National Academy of Sciences of the United States of America 103, no. 27 (2006): 10207-10212. Full Text
  - Wood, KC, Boedicker, JQ, Lynn, DM, and Hammond, PT. "Tunable drug release from hydrolytically degradable layer-by-layer thin films." Langmuir 21, no. 4 (2005): 1603-1609. Full Text
  - Wood, KC, Little, SR, Langer, R, and Hammond, PT. "A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery." Angewandte Chemie - International Edition 44, no. 41 (2005): 6704-6708. Full Text
  - Meyer, DE, Wood, K, Bachas, LG, and Bhattacharyya, D. "Degradation of chlorinated organics by membrane-immobilized nanosized metals." Environmental Progress 23, no. 3 (2004): 232-242. Full Text
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

In the News

Selected Grants

Selected Publications

Journal Articles

Recent Courses