Scholars@Duke

• Background
• 

  Education, Training, and Certifications

  • Ph.D., Massachusetts Institute of Technology 2007
  • B.S., University of Kentucky at Lexington 2002
• Recognition
• 

  In the News

  • NOV 19, 2015

    Duke Research Blog

    The Challenges of Combating Cancer Drug Resistance

  • JAN 5, 2015

    Researchers Map Paths to Cancer Drug Resistance
• Research
• 

  Selected Grants

  • Selectively targeting apoptosis in PIK3CA mutant colorectal cancers  awarded by National Institutes of Health 2016 - 2021
  • Bioinformatics and Computational Biology Training Program  awarded by National Institutes of Health 2005 - 2021
  • Genetics Training Grant  awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure  awarded by National Institutes of Health 1975 - 2020
  • Pharmacological Sciences Training Program  awarded by National Institutes of Health 1975 - 2020
  • Topological Methods for Morphology: Classifying Shape and Function via Dictionary Learning  awarded by Columbia University 2016 - 2020
  • Pharmacology Industry Internships for Ph.D. Students  awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
  • Targeting the Hippo pathway in Ras-driven rhabdomyosarcoma  awarded by V Foundation for Cancer Research 2016 - 2019
  • Targeting differential apoptosis regulation in triple negative breast cancer  awarded by Department of Defense 2016 - 2019
  • Exploring BCL-XL addiction in pancreatic ductal adenocarcinoma  awarded by National Institutes of Health 2016 - 2019
  • RalA signal transduction  awarded by National Institutes of Health 2002 - 2019
  • Integration of signaling and metabolic pathways in the regulation of EMT  awarded by US-Israel Binational Science Foundation 2016 - 2018
  • Profiling Gene Interactions in the Human Kinome  awarded by  National Science Foundation 2015 - 2018
  • Targeting undruggable oncogenes through the epigenome  awarded by Element Genomics, Inc. 2017 - 2018
  • Designing durable apoptosis-targeting therapies for acute myeloid leukemia  awarded by National Institutes of Health 2016 - 2018
  • Mapping the landscape of drug sensitizers in human cancers  awarded by National Institutes of Health 2015 - 2018
  • Defining new combination therapies for high-grade serous ovarian cancer  awarded by Ovarian Cancer Research Fund, Inc. 2015 - 2018
  • Genomic and Computational Approaches for Development of Novel Anticancer Therapies  awarded by Schlumberger Foundation 2015 - 2017
  • Identification of synthetic lethal interactors in pancreatic cancer  awarded by University of North Carolina - Chapel Hill 2015 - 2017
  • Medical Scientist Training Program  awarded by National Institutes of Health 1997 - 2017
  • Systematic design of CDK4/6 inhibitor-based combination therapies  awarded by G1 Therapeutics Inc. 2015 - 2016
  • A Platform for Real-time Drug Profiling of Patient-Derived Melanomas  awarded by National Institutes of Health 2014 - 2016
  • Cancer Biology Training Grant  awarded by National Cancer Institute 1993 - 2016
  • Systematic dissection of the breast cancer microenvironment using the MicroSCALE Toolkit  awarded by V Foundation for Cancer Research 2013 - 2015
• Publications and Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Wood, KC. "Suppressing oncogenic transcription with a little healthy competition." Science translational medicine 9, no. 374 (January 2017).  Full Text
    • Anderson, GR, Wardell, SE, Cakir, M, Crawford, L, Leeds, JC, Nussbaum, DP, Shankar, PS, Soderquist, RS, Stein, EM, Tingley, JP, Winter, PS, Zieser-Misenheimer, EK, Alley, HM, Yllanes, A, Haney, V, Blackwell, KL, McCall, SJ, McDonnell, DP, and Wood, KC. "PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation." Science translational medicine 8, no. 369 (December 2016): 369ra175-.  Full Text  Open Access Copy
    • Wood, KC. "An EXITS strategy for decreasing cancer risk in women." Science translational medicine 8, no. 368 (December 2016): 368ec197-.  Full Text
    • Wood, KC. "Hacking T cells with synthetic circuits to program antitumor responses." Science Translational Medicine 8, no. 362 (October 26, 2016): 362ec172-362ec172.  Full Text
    • Wood, KC. "Mapping a path for precision cancer therapies." Science Translational Medicine 8, no. 348 (July 20, 2016): 348ec115-348ec115.  Full Text
    • Singleton, KR, and Wood, KC. "Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes." Genes & cancer 7, no. 7-8 (July 2016): 218-228. (Review)  Open Access Copy
    • Wood, KC. "Targeting the cancer cells that just wont go away." Science Translational Medicine 8, no. 344 (June 22, 2016): 344ec101-344ec101.  Full Text
    • Lin, KH, Winter, PS, Xie, A, Roth, C, Martz, CA, Stein, EM, Anderson, GR, Tingley, JP, and Wood, KC. "Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia." Scientific reports 6 (June 10, 2016): 27696-.  Full Text
    • Cribb, JA, Osborne, LD, Beicker, K, Psioda, M, Chen, J, O'Brien, ET, Taylor Ii, RM, Vicci, L, Hsiao, JP-L, Shao, C, Falvo, M, Ibrahim, JG, Wood, KC, Blobe, GC, and Superfine, R. "An Automated High-throughput Array Microscope for Cancer Cell Mechanics." Scientific reports 6 (June 6, 2016): 27371-.  Full Text
    • Wood, KC. "Collaborating tumor cells overcome multitargeted antiangiogenic therapies." Science Translational Medicine 8, no. 338 (May 11, 2016).
    • Park, S, Chang, C-Y, Safi, R, Liu, X, Baldi, R, Jasper, JS, Anderson, GR, Liu, T, Rathmell, JC, Dewhirst, MW, Wood, KC, Locasale, JW, and McDonnell, DP. "ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer." Cell reports 15, no. 2 (April 2016): 323-335.  Full Text
    • Wood, KC. "Intercepting reversible drug tolerance to improve targeted therapy." Science Translational Medicine 8, no. 332 (March 30, 2016): 332ec52-332ec52.  Full Text
    • Wood, KC. "Mapping the Pathways of Resistance to Targeted Therapies." Cancer research 75, no. 20 (October 2015): 4247-4251. (Review)  Full Text
    • Misale, S, Bozic, I, Tong, J, Peraza-Penton, A, Lallo, A, Baldi, F, Lin, KH, Truini, M, Trusolino, L, Bertotti, A, Di Nicolantonio, F, Nowak, MA, Zhang, L, Wood, KC, and Bardelli, A. "Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers." Nature communications 6 (September 22, 2015): 8305-.  Full Text
    • Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of clinical investigation 125, no. 1 (January 2015): 194-207.  Full Text  Open Access Copy
    • Martz, CA, Ottina, KA, Singleton, KR, Jasper, JS, Wardell, SE, Peraza-Penton, A, Anderson, GR, Winter, PS, Wang, T, Alley, HM, Kwong, LN, Cooper, ZA, Tetzlaff, M, Chen, P-L, Rathmell, JC, Flaherty, KT, Wargo, JA, McDonnell, DP, Sabatini, DM, and Wood, KC. "Systematic identification of signaling pathways with potential to confer anticancer drug resistance." Science signaling 7, no. 357 (December 23, 2014): ra121-.  Full Text
    • Winter, PS, Sarosiek, KA, Lin, KH, Meggendorfer, M, Schnittger, S, Letai, A, and Wood, KC. "RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis." Science signaling 7, no. 357 (December 23, 2014): ra122-.  Full Text
    • Wood, KC, and VanHook, AM. "Science Signaling Podcast: 23 December 2014." Science Signaling 7, no. 357 (December 23, 2014): pc33-pc33.  Full Text
    • Wood, KB, Wood, KC, Nishida, S, and Cluzel, P. "Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells." Cell reports 6, no. 6 (March 6, 2014): 1073-1084.  Full Text
    • Wood, KC, Konieczkowski, DJ, Johannessen, CM, Boehm, JS, Tamayo, P, Botvinnik, OB, Mesirov, JP, Hahn, WC, Root, DE, Garraway, LA, and Sabatini, DM. "MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma." Science Signaling 5, no. 224 (2012).  Full Text
    • Wood, KC, and Sabatini, DM. "Growth Signaling at the Nexus of Stem Cell Life and Death." Cell Stem Cell 5, no. 3 (2009): 232-234.  Full Text
    • Wood, KC, Azarin, SM, Arap, W, Pasqualini, R, Langer, R, and Hammond, PT. "Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide." Bioconjugate Chemistry 19, no. 2 (2008): 403-405.  Full Text
    • Wood, KC, Zacharia, NS, Schmidt, DJ, Wrightman, SN, Andaya, BJ, and Hammond, PT. "Electroactive controlled release thin films." Proceedings of the National Academy of Sciences of the United States of America 105, no. 7 (2008): 2280-2285.  Full Text
    • Wood, KC, Chuang, HF, Batten, RD, Lynn, DM, and Hammond, PT. "Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films." Proceedings of the National Academy of Sciences of the United States of America 103, no. 27 (2006): 10207-10212.  Full Text
    • Wood, KC, Boedicker, JQ, Lynn, DM, and Hammond, PT. "Tunable drug release from hydrolytically degradable layer-by-layer thin films." Langmuir 21, no. 4 (2005): 1603-1609.  Full Text
    • Wood, KC, Little, SR, Langer, R, and Hammond, PT. "A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery." Angewandte Chemie - International Edition 44, no. 41 (2005): 6704-6708.  Full Text
    • Meyer, DE, Wood, K, Bachas, LG, and Bhattacharyya, D. "Degradation of chlorinated organics by membrane-immobilized nanosized metals." Environmental Progress 23, no. 3 (2004): 232-242.  Full Text
• Teaching and Mentoring
• 

  Recent Courses

  • MOLCAN 818: Molecular Mechanisms of Oncogenesis 2017
  • PHARM 393: Research Independent Study 2017
  • PHARM 394: Research Independent Study 2017
  • PHARM 493: Research Independent Study 2017
  • PHARM 494: Research Independent Study 2017
  • PHARM 818: Molecular Mechanisms of Oncogenesis 2017
  • MOLCAN 780: Graduate Student Seminar 2016
  • PHARM 780S: Graduate Student Seminar 2016

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