Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Massachusetts Institute of Technology 2007
  • B.S., University of Kentucky at Lexington 2002
• 

  Duke Appointment History

  • Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016 - 2019
• Recognition
• 

  In the News

  • SEP 16, 2019

    Pratt School of Engineering

    Cancer Therapy Using Genetic Targeting and Gel Delivery Shows Promise

  • OCT 3, 2018

    Duke Med Alumni News

    From Innovation to Impact

  • APR 9, 2018

    Faculty Startup Sold to Belgian Pharma for $30 Million

  • OCT 25, 2017

    Duke Cancer Institute

    Why Do Perfectly Good Cancer Treatments Suddenly Stop Working?

  • NOV 19, 2015

    Duke Research Blog

    The Challenges of Combating Cancer Drug Resistance

  • JAN 5, 2015

    Researchers Map Paths to Cancer Drug Resistance
• Research
• 

  Selected Grants

  • Identification and Characterization of Novel Cis-Regulatory Elements Controlling PTEN Expression awarded by National Institutes of Health 2020 - 2022
  • Targeting tumor-specific apoptosis regulation in advanced ER+ breast cancer awarded by Department of Defense 2019 - 2022
  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
  • Computational Structure-Based Protein Design Non-competing Renewal (Yr. 10) awarded by National Institutes of Health 2008 - 2022
  • Selectively targeting apoptosis in PIK3CA mutant colorectal cancers awarded by National Institutes of Health 2016 - 2021
  • Decoding human genetic variation by functional dissection of beta2-adrenergic receptor signaling awarded by  American Heart Association 2019 - 2021
  • Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance awarded by National Institutes of Health 2017 - 2021
  • Determining the Sub-Cellular Organelles that Link Lipid Signaling and Epigenetics awarded by National Institutes of Health 2019 - 2021
  • High-throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity 2018 - 2020
  • Mechanisms of immune checkpoint resistance mediated by LKB1 tumor suppressor in lung cancer awarded by Department of Defense 2019 - 2020
  • Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
  • Topological Methods for Morphology: Classifying Shape and Function via Dictionary Learning awarded by Columbia University 2016 - 2020
  • Identification and validation of the PAX3-FOXO1 protein interactome 2018 - 2020
  • Single cell functional dissection of tumor microenviornment-driven drug resistance awarded by National Institutes of Health 2018 - 2020
  • Precision targeting of altered mitochondrial states in ovarian cancer 2015 - 2020
  • Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
  • Targeting the Hippo pathway in Ras-driven rhabdomyosarcoma awarded by V Foundation for Cancer Research 2016 - 2019
  • Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
  • Identification of synthetic lethal interactors in pancreatic cancer awarded by University of North Carolina - Chapel Hill 2015 - 2019
  • Exploring BCL-XL addiction in pancreatic ductal adenocarcinoma awarded by National Institutes of Health 2016 - 2019
  • RalA signal transduction awarded by National Institutes of Health 2002 - 2019
  • Copy Number Alterations in Low Mutation Cancer awarded by National Institutes of Health 2018 - 2019
  • Exploiting collateral sensitivity to target kinase inhibitor-resistant lung cancers awarded by Burroughs Wellcome Fund 2017 - 2018
  • Unmasking targetable dependencies in cancer with intrinsic or acquired resistance to anti-cancer therapies awarded by National Institutes of Health 2017 - 2018
  • Integration of signaling and metabolic pathways in the regulation of EMT 2016 - 2018
  • Profiling Gene Interactions in the Human Kinome awarded by  National Science Foundation 2015 - 2018
  • Targeting undruggable oncogenes through the epigenome 2017 - 2018
  • Designing durable apoptosis-targeting therapies for acute myeloid leukemia awarded by National Institutes of Health 2016 - 2018
  • Mapping the landscape of drug sensitizers in human cancers awarded by National Institutes of Health 2015 - 2017
  • Genomic and Computational Approaches for Development of Novel Anticancer Therapies 2015 - 2017
  • Systematic design of CDK4/6 inhibitor-based combination therapies 2015 - 2016
  • A Platform for Real-time Drug Profiling of Patient-Derived Melanomas awarded by National Institutes of Health 2014 - 2016
  • Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
  • Systematic dissection of the breast cancer microenvironment using the MicroSCALE Toolkit awarded by V Foundation for Cancer Research 2013 - 2015
• 

  Industry Relationships

  • Celldom, Inc.
  • Element Genomics
  • Tavros Therapeutics
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zhong, Zheng, Sugunavathi Sepramaniam, Xin Hui Chew, Kris Wood, May Ann Lee, Babita Madan, and David M. Virshup. “PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers..” Oncogene 38, no. 40 (October 2019): 6662–77. https://doi.org/10.1038/s41388-019-0908-1.
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    • Manzari, Mandana T., Grace R. Anderson, Kevin H. Lin, Ryan S. Soderquist, Merve Çakir, Mitchell Zhang, Chandler E. Moore, et al. “Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models..” Sci Adv 5, no. 9 (September 2019). https://doi.org/10.1126/sciadv.aaw9162.
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    • Cakir, Merve, Sayan Mukherjee, and Kris C. Wood. “Label propagation defines signaling networks associated with recurrently mutated cancer genes..” Sci Rep 9, no. 1 (June 28, 2019). https://doi.org/10.1038/s41598-019-45603-3.
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    • Lin, Kevin H., Abigail Xie, Justine C. Rutter, Yeong-Ran Ahn, Julia M. Lloyd-Cowden, Amanda G. Nichols, Ryan S. Soderquist, et al. “Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity..” Cell Metab 29, no. 5 (May 7, 2019): 1217-1231.e7. https://doi.org/10.1016/j.cmet.2019.01.011.
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    • Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer..” Plos One 14, no. 5 (2019). https://doi.org/10.1371/journal.pone.0216934.
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    • Ding, Yi, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H. Lin, Gehao Liang, et al. “Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers..” Nat Commun 9, no. 1 (October 15, 2018). https://doi.org/10.1038/s41467-018-06651-x.
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    • Soderquist, Ryan S., Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir, and Kris C. Wood. “Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity..” Nat Commun 9, no. 1 (August 29, 2018). https://doi.org/10.1038/s41467-018-05815-z.
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    • Ohiri, Korine A., Sean T. Kelly, Jeffrey D. Motschman, Kevin H. Lin, Kris C. Wood, and Benjamin B. Yellen. “An acoustofluidic trap and transfer approach for organizing a high density single cell array..” Lab Chip 18, no. 14 (July 10, 2018): 2124–33. https://doi.org/10.1039/c8lc00196k.
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    • Winter, Peter S., and Kris C. Wood. “Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers..” Trends Cancer 4, no. 5 (May 2018): 333–35. https://doi.org/10.1016/j.trecan.2018.02.004.
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    • Anderson, Grace R., Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-Ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell, and Kris C. Wood. “Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors..” Nat Commun 9, no. 1 (April 26, 2018). https://doi.org/10.1038/s41467-018-04033-x.
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    • Crawford, Lorin, Kris C. Wood, Xiang Zhou, and Sayan Mukherjee. “Bayesian Approximate Kernel Regression with Variable Selection..” J Am Stat Assoc 113, no. 524 (2018): 1710–21. https://doi.org/10.1080/01621459.2017.1361830.
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    • Singleton, Katherine R., Lorin Crawford, Elizabeth Tsui, Haley E. Manchester, Ophelia Maertens, Xiaojing Liu, Maria V. Liberti, et al. “Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence..” Cell Rep 21, no. 10 (December 5, 2017): 2796–2812. https://doi.org/10.1016/j.celrep.2017.11.022.
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    • Anderson, Grace R., Peter S. Winter, Kevin H. Lin, Daniel P. Nussbaum, Merve Cakir, Elizabeth M. Stein, Ryan S. Soderquist, et al. “A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution..” Cell Rep 20, no. 4 (July 25, 2017): 999–1015. https://doi.org/10.1016/j.celrep.2017.07.006.
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    • Ali, Moiez, Erin Kaltenbrun, Grace R. Anderson, Sarah Jo Stephens, Sabrina Arena, Alberto Bardelli, Christopher M. Counter, and Kris C. Wood. “Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance..” Nat Commun 8 (June 8, 2017). https://doi.org/10.1038/ncomms15617.
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    • Price, Alexander M., Joanne Dai, Quentin Bazot, Luv Patel, Pavel A. Nikitin, Reza Djavadian, Peter S. Winter, et al. “Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection..” Elife 6 (April 20, 2017). https://doi.org/10.7554/eLife.22509.
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    • Wood, Kris C. “Suppressing oncogenic transcription with a little healthy competition..” Sci Transl Med 9, no. 374 (January 25, 2017). https://doi.org/10.1126/scitranslmed.aal5000.
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    • Anderson, Grace R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, et al. “PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation..” Sci Transl Med 8, no. 369 (December 14, 2016). https://doi.org/10.1126/scitranslmed.aae0348.
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    • Wood, Kris C. “An EXITS strategy for decreasing cancer risk in women..” Sci Transl Med 8, no. 368 (December 7, 2016). https://doi.org/10.1126/scitranslmed.aal2806.
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    • Wood, K. C. “Hacking T cells with synthetic circuits to program antitumor responses.” Science Translational Medicine 8, no. 362 (October 26, 2016). https://doi.org/10.1126/scitranslmed.aai9170.
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    • Wood, K. C. “Two faces of circulating breast cancer cells.” Science Translational Medicine 8, no. 356 (September 14, 2016). https://doi.org/10.1126/scitranslmed.aah7023.
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    • Wood, K. C. “Mapping a path for precision cancer therapies.” Science Translational Medicine 8, no. 348 (July 20, 2016). https://doi.org/10.1126/scitranslmed.aah4512.
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    • Singleton, Katherine R., and Kris C. Wood. “Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes..” Genes Cancer 7, no. 7–8 (July 2016): 218–28. https://doi.org/10.18632/genesandcancer.112.
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    • Wood, K. C. “Targeting the cancer cells that just won't go away.” Science Translational Medicine 8, no. 344 (June 22, 2016). https://doi.org/10.1126/scitranslmed.aag2112.
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    • Lin, Kevin H., Peter S. Winter, Abigail Xie, Cullen Roth, Colin A. Martz, Elizabeth M. Stein, Grace R. Anderson, Jennifer P. Tingley, and Kris C. Wood. “Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia..” Sci Rep 6 (June 10, 2016). https://doi.org/10.1038/srep27696.
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    • Cribb, Jeremy A., Lukas D. Osborne, Kellie Beicker, Matthew Psioda, Jian Chen, E Timothy O’Brien, Russell M. Taylor Ii, et al. “An Automated High-throughput Array Microscope for Cancer Cell Mechanics..” Sci Rep 6 (June 6, 2016). https://doi.org/10.1038/srep27371.
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    • Wood, K. C. “Collaborating tumor cells overcome multitargeted antiangiogenic therapies.” Science Translational Medicine 8, no. 338 (May 11, 2016). https://doi.org/10.1126/scitranslmed.aaf9190.
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    • Park, Sunghee, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, et al. “ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer..” Cell Rep 15, no. 2 (April 12, 2016): 323–35. https://doi.org/10.1016/j.celrep.2016.03.026.
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    • Wood, K. C. “Intercepting reversible drug tolerance to improve targeted therapy.” Science Translational Medicine 8, no. 332 (March 30, 2016). https://doi.org/10.1126/scitranslmed.aaf6467.
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    • Son, Sungmin, Mark M. Stevens, Hui Xiao Chao, Carson Thoreen, Aaron M. Hosios, Lawrence D. Schweitzer, Yaochung Weng, et al. “Cooperative nutrient accumulation sustains growth of mammalian cells..” Sci Rep 5 (December 1, 2015). https://doi.org/10.1038/srep17401.
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    • Wood, Kris C. “Mapping the Pathways of Resistance to Targeted Therapies..” Cancer Res 75, no. 20 (October 15, 2015): 4247–51. https://doi.org/10.1158/0008-5472.CAN-15-1248.
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    • Misale, Sandra, Ivana Bozic, Jingshan Tong, Ashley Peraza-Penton, Alice Lallo, Federica Baldi, Kevin H. Lin, et al. “Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers..” Nat Commun 6 (September 22, 2015). https://doi.org/10.1038/ncomms9305.
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    • Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation..” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.
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    • Martz, Colin A., Kathleen A. Ottina, Katherine R. Singleton, Jeff S. Jasper, Suzanne E. Wardell, Ashley Peraza-Penton, Grace R. Anderson, et al. “Systematic identification of signaling pathways with potential to confer anticancer drug resistance..” Sci Signal 7, no. 357 (December 23, 2014). https://doi.org/10.1126/scisignal.aaa1877.
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    • Winter, Peter S., Kristopher A. Sarosiek, Kevin H. Lin, Manja Meggendorfer, Susanne Schnittger, Anthony Letai, and Kris C. Wood. “RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis..” Sci Signal 7, no. 357 (December 23, 2014). https://doi.org/10.1126/scisignal.2005301.
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    • Wood, Kevin B., Kris C. Wood, Satoshi Nishida, and Philippe Cluzel. “Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells..” Cell Rep 6, no. 6 (March 27, 2014): 1073–84. https://doi.org/10.1016/j.celrep.2014.02.007.
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    • Wood, K. C., and A. M. VanHook. “Science signaling podcast: 23 December 2014.” Science Signaling 7, no. 357 (January 1, 2014). https://doi.org/10.1126/scisignal.aaa4213.
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    • Wood, Kris C., David J. Konieczkowski, Cory M. Johannessen, Jesse S. Boehm, Pablo Tamayo, Olga B. Botvinnik, Jill P. Mesirov, et al. “MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma..” Sci Signal 5, no. 224 (May 15, 2012). https://doi.org/10.1126/scisignal.2002612.
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    • Wood, Kris C., and David M. Sabatini. “Growth signaling at the nexus of stem cell life and death..” Cell Stem Cell 5, no. 3 (September 4, 2009): 232–34. https://doi.org/10.1016/j.stem.2009.08.008.
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    • Wood, Kris C., Nicole S. Zacharia, Daniel J. Schmidt, Stefani N. Wrightman, Brian J. Andaya, and Paula T. Hammond. “Electroactive controlled release thin films..” Proc Natl Acad Sci U S A 105, no. 7 (February 19, 2008): 2280–85. https://doi.org/10.1073/pnas.0706994105.
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    • Wood, Kris C., Samira M. Azarin, Wadih Arap, Renata Pasqualini, Robert Langer, and Paula T. Hammond. “Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide..” Bioconjug Chem 19, no. 2 (February 2008): 403–5. https://doi.org/10.1021/bc700408r.
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    • Wood, K. C., H. F. Chuang, R. D. Batten, D. M. Lynn, and P. T. Hammond. “Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films.” Proceedings of the National Academy of Sciences of the United States of America 103, no. 27 (July 4, 2006): 10207–12. https://doi.org/10.1073/pnas.0602884103.
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    • Wood, Kris C., Steven R. Little, Robert Langer, and Paula T. Hammond. “A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery..” Angew Chem Int Ed Engl 44, no. 41 (October 21, 2005): 6704–8. https://doi.org/10.1002/anie.200502152.
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    • Wood, K. C., J. Q. Boedicker, D. M. Lynn, and P. T. Hammond. “Tunable drug release from hydrolytically degradable layer-by-layer thin films.” Langmuir 21, no. 4 (February 15, 2005): 1603–9. https://doi.org/10.1021/la0476480.
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    • Meyer, D. E., K. Wood, L. G. Bachas, and D. Bhattacharyya. “Degradation of chlorinated organics by membrane-immobilized nanosized metals.” Environmental Progress 23, no. 3 (October 1, 2004): 232–42. https://doi.org/10.1002/ep.10031.
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  • Conference Papers

    • Wood, Kris C. “Leveraging Synthetic Lethality to Target Convergent Therapeutic Resistance.” In Faseb Journal, Vol. 31. FEDERATION AMER SOC EXP BIOL, 2017.
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• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 394: Research Independent Study 2020
  • PHARM 494: Research Independent Study 2020
  • PHARM 495: Research Independent Study 2020
  • BIOLOGY 728A: University Program in Genetics and Genomics Biological Solutions Module I 2019
  • CMB 710E: Cell & Molecular Biology Module V 2019
  • CMB 778A: University Program in Genetics and Genomics Biological Solutions Module I 2019
  • MGM 778A: University Program in Genetics and Genomics Biological Solutions Module I 2019
  • MOLCAN 818: Molecular Mechanisms of Oncogenesis 2019
  • PHARM 393: Research Independent Study 2019
  • PHARM 493: Research Independent Study 2019
  • PHARM 818: Molecular Mechanisms of Oncogenesis 2019
  • UPGEN 778A: University Program in Genetics and Genomics Biological Solutions Module I 2019
  • BIOLOGY 728E: University Program in Genetics and Genomics Biological Solutions Module V 2018
  • CMB 710D: Cell & Molecular Biology Module IV 2018
  • CMB 778E: University Program in Genetics and Genomics Biological Solutions Module V 2018
  • MGM 778E: University Program in Genetics and Genomics Biological Solutions Module V 2018
  • UPGEN 778E: University Program in Genetics and Genomics Biological Solutions Module V 2018

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.