Kristin M. Schroeder

Journal article Neurooncol Pract · June 2026 BACKGROUND: Central nervous system (CNS) tumors are a significant cause of morbidity and mortality in Sub-Saharan Africa (SSA). This project aimed to assess and map out the current neuro-oncology capacity in SSA, brain tumor registries, and biobanks. METHO ... Full text Link to item Cite

Evaluating the Safety of a Ketamine Sedation Protocol In a Pediatric Oncology Population in Tanzania: A Quality Improvement Project.

Journal article AANA J · April 1, 2026 This project aimed to reintroduce and evaluate a pediatric ketamine sedation protocol at a Zonal Referral Center in Mwanza, Tanzania, where nonanesthesia clinicians provide sedation when trained anesthesia personnel are unavailable. The objectives were to ... Full text Link to item Cite

Overcoming Cancer Disparities Globally: Contributions of Norman Coleman.

Journal article Disaster Med Public Health Prep · March 24, 2026 Dr. C. Norman Coleman, a distinguished cancer specialist and researcher, brought a passion for addressing health disparities to all of his roles from being on the faculty as a Radiation Oncologist at Stanford, as Chair of the Joint Center for Radiation Onc ... Full text Link to item Cite

Implementation Science Methodology for the Successful Introduction of High-Dose Methotrexate for the Treatment of Pediatric Mature B-Cell Non-Hodgkin Lymphoma in a Resource-Limited Setting.

Journal article Pediatr Blood Cancer · March 2026 BACKGROUND: Despite the excellent outcomes achieved for pediatric mature B-cell non-Hodgkin lymphoma (MB-NHL) in high-income countries, outcomes remain very poor in low- and middle-income countries. High-dose methotrexate (HD-MTX), which is highly efficaci ... Full text Link to item Cite

Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania.

Journal article BMC Med · February 21, 2026 BACKGROUND: Burkitt Lymphoma (BL) is a prevalent and highly aggressive childhood cancer in sub-Saharan Africa (SSA). Outcomes are poor, due in part to delays or inaccuracies in diagnosis. Liquid biopsy (sequencing circulating tumour DNA from blood) is an a ... Full text Link to item Cite

Chemotherapy-Induced Toxicities in Pediatric Cancer Patients: A Cross-Sectional Survey Using a Child- and Caregiver-Reported Outcome Tool in Tanzania.

Journal article Drug Healthc Patient Saf · 2026 BACKGROUND: Chemotherapy remains the cornerstone of pediatric cancer treatment, yet its cytotoxic nature often results in chemotherapy-induced toxicities, adverse effects arising from damage to healthy, rapidly dividing cells. Data describing these toxicit ... Full text Link to item Cite

Patient Concerns on Access to Supportive Care Medicines and Symptom Management Outcomes Among Children with Cancer in Tanzania.

Journal article J Pediatr Hematol Oncol Nurs · 2026 BackgroundPediatric cancers cause significant morbidity and mortality among children in Tanzania. Chemotherapy remains the primary treatment, but it often leads to treatment-induced toxicities that necessitate supportive care medicines. This study assessed ... Full text Link to item Cite

The growing and urgent need for interventions to mitigate cancer-related stigma in sub-Saharan Africa.

Journal article Glob Ment Health (Camb) · 2026 Cancer stigma, both underaddressed and understudied, remains a pervasive challenge in sub-Saharan Africa. Currently, the region is experiencing rising cancer incidence alongside some of the lowest cancer survival rates worldwide. With complex and multiface ... Full text Link to item Cite

Prospective Psychometric Validation of the Swahili Translated and Adapted Pediatric Patient Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (Ped-PRO-CTCAE).

Journal article Meas Eval Cancer Care · December 2025 BACKGROUND: High quality clinical research is necessary in order to address the significant disparities in pediatric cancer outcomes seen in low- and middle-income countries (LMICs). Patient reported outcomes are now recognized as a critical part of many c ... Full text Link to item Cite

A peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial.

Journal article Nat Cancer · September 2025 The human cytomegalovirus (CMV) antigen pp65 is expressed in high-grade glioma (HGG) and medulloblastoma but not in the adjacent brain. This single-arm phase 1 trial ( NCT03299309 ) assessed the safety and immunogenicity of a peptide vaccine (PEP-CMV) targ ... Full text Open Access Link to item Cite

Nutritional Status and Chemotherapy-Induced Toxicities in Children with Cancer: Implications for Care in Low-Resource Settings

Journal article Bratislava Medical Journal · September 1, 2025 Background: Childhood cancer is an increasing public health issue, particularly in low- and middle-income countries, where over 80% of new cases arise. Malnutrition is common in these settings and may worsen chemotherapy-induced toxicities. This scoping re ... Full text Cite

Nutritional status and barriers to optimal nutrition among pediatric patients with cancer in tanzania: a quantitative analysis.

Journal article J Health Popul Nutr · June 5, 2025 BACKGROUND: Childhood cancer is a growing public health concern in low- and middle-income countries (LMICs), where over two-thirds of global pediatric cancer cases occur. Despite advances in diagnosis and treatment, malnutrition remains a major barrier to ... Full text Link to item Cite

Rituximab for children with EBV-positive Burkitt lymphoma in East Africa.

Journal article Blood Adv · May 27, 2025 The addition of rituximab to the chemotherapy backbone was shown to significantly improve outcomes of children with aggressive high-grade lymphomas in high-income countries. However, data on its safety and efficacy in children with Epstein-Barr virus (EBV) ... Full text Link to item Cite

Childhood Cancer Survivorship Care in Limited Resource Settings: A Narrative Review and Strategies to Promote Global Health Equity.

Journal article JCO Glob Oncol · February 2025 The WHO Global Initiative for Childhood Cancer, prompted by the marked inequity of survival across the globe, aims to increase survival rates in low- and middle-income countries to 60% by 2030. In tandem with this effort, implementing survivorship-focused ... Full text Link to item Cite

Targeted Next-Generation Sequencing of Cell-Free DNA to Detect MYC-Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa.

Journal article JCO Glob Oncol · January 2025 PURPOSE: Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) affects children in sub-Saharan Africa, but diagnosis via tissue biopsy is challenging. We explored a liquid biopsy approach using targeted next-generation sequencing to detect the MYC-immuno ... Full text Link to item Cite

Pharmacogenomics of Chemotherapies for Childhood Cancers in Africa: A Scoping Review.

Journal article Pharmgenomics Pers Med · 2025 BACKGROUND: Pharmacogenomics holds significant promise in improving the efficacy and safety of chemotherapy for childhood cancers. However, the field remains underexplored in Africa, where high genetic diversity and substantial disease burdens, including c ... Full text Link to item Cite

Prescription patterns of supportive care medications among children receiving chemotherapy treatments at a major referral hospital in Tanzania: where are we in managing chemotherapy-induced toxicities?

Journal article Front Oncol · 2025 BACKGROUND: Cancer chemotherapy is a treatment that systematically kills cancer cells but causes expected side effects, known as chemotherapy-induced toxicities. These toxicities are managed with supportive care medications. This study aimed to determine t ... Full text Link to item Cite

Sub-Saharan African experience of neurosurgical oncology care: challenges and barriers encountered at 7 cancer treatment centers.

Journal article J Neurosurg · December 1, 2024 OBJECTIVE: Wide disparities in neurosurgical oncology care and treatment outcomes exist globally despite recent improvements in diagnostics and cancer therapy. To better understand the challenges to neurosurgical oncology care in low-resource settings, the ... Full text Link to item Cite

The socio-cultural contexts shaping health-seeking behaviours among community members regarding childhood cancer in Tanzania: A qualitative study.

Journal article Pediatr Blood Cancer · November 2024 BACKGROUND: Timely diagnosis of childhood cancer, early hospital presentation and completion of treatment significantly improve outcomes. Unfortunately, in Tanzania, thousands of children die of cancer each year without ever being diagnosed or treated. To ... Full text Link to item Cite

Retrospective analysis of pediatric patients with Burkitt lymphoma treated in Tanzania following the implementation of the 2016 National Treatment Guidelines: Poor outcomes to current standard-of-care therapy.

Journal article Pediatr Blood Cancer · September 2024 BACKGROUND: Despite the excellent outcomes achieved in the treatment of pediatric Burkitt lymphoma (BL) in high-income countries (HICs), outcomes remain poor in low- and middle-income countries (LMICs). Efforts to improve BL outcomes in Tanzania included t ... Full text Link to item Cite

Immunohistochemistry effect on diagnostic reliability for paediatric cancer at Mwanza region, Tanzania: a laboratory descriptive study.

Journal article Ecancermedicalscience · 2024 INTRODUCTION: In nations with poor and intermediate incomes, cancer is one of the main causes of mortality. Immunohistochemistry (IHC) is crucial for an accurate cancer evaluation, prognosis and treatment decision-making. To use IHC, a significant amount o ... Full text Link to item Cite

Establishment of a brain tumor consortium of Africa: Advancing collaborative research and advocacy for brain tumors in Africa.

Journal article Neurooncol Adv · 2024 BACKGROUND: Brain tumors represent a significant global health challenge, with rising incidence and mortality impacting individuals worldwide and contributing to cancer-related morbidity and mortality. In Africa, this burden is exacerbated by limited acces ... Full text Link to item Cite

Wilms tumor treatment protocol compliance and the influence on outcomes for children in Tanzania.

Journal article Pediatr Blood Cancer · December 2023 BACKGROUND: Standardized Wilms tumor treatment protocols exist for low- and middle-income countries, but outcomes equivalent to high-income countries are not achieved outside of clinical trials. As Wilms tumor treatment protocols in Africa shift with incre ... Full text Link to item Cite

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.

Journal article Lancet Child Adolesc Health · July 2023 BACKGROUND: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel approach for treatment of recurrent paediatric ... Full text Link to item Cite

Swahili translation and cultural adaptation of the pediatric patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE).

Journal article J Patient Rep Outcomes · June 12, 2023 BACKGROUND: The pediatric patient-reported outcomes version of the common terminology criteria for adverse event measure was developed and validated for use in pediatric cancer clinical trials to better capture the symptom experiences through direct self-r ... Full text Link to item Cite

Childhood and Adolescent Cancer Care at a Tertiary Hospital in Northern Tanzania: A Retrospective Study.

Journal article JCO Glob Oncol · June 2023 PURPOSE: Over 400,000 children are diagnosed with cancer around the world each year, with over 80% of these children residing in low- and middle-income countries. This study aims to summarize the epidemiology and care patterns of newly diagnosed childhood ... Full text Link to item Cite

Use of Trametinib in Children and Young Adults With Progressive Low-grade Glioma and Glioneuronal Tumors.

Journal article J Pediatr Hematol Oncol · May 1, 2023 Low-grade gliomas/glioneuronal tumors comprise one-third of all pediatric-type CNS tumors. These tumors are generally caused by activating mutations in the mitogen-activated protein kinase (MAPK) pathway. Targeted drugs, such as trametinib, have shown prom ... Full text Link to item Cite

Access to essential cancer medicines for children: a comparative mixed-methods analysis of availability, price, and health-system determinants in east Africa.

Journal article Lancet Oncol · May 2023 BACKGROUND: Access to essential childhood cancer medicines is a core determinant of childhood cancer outcomes. Available evidence, although scarce, suggests that access to these medicines is highly variable across countries, particularly in low-income and ... Full text Link to item Cite

Delays in cancer care for children in low-income and middle-income countries: development of a composite vulnerability index.

Journal article Lancet Glob Health · April 2023 BACKGROUND: Early access to diagnosis and care is essential to improve rates of survival from childhood cancer, particularly in low-income and middle-income countries (LMICs). Composite indices are increasingly used to compare country performance in many h ... Full text Link to item Cite

Determinants of delayed childhood cancer care in low- and middle-income countries: A systematic review.

Journal article Pediatr Blood Cancer · March 2023 Early access to care is essential to improve survival rates for childhood cancer. This study evaluates the determinants of delays in childhood cancer care in low- and middle-income countries (LMICs) through a systematic review of the literature. We propose ... Full text Link to item Cite

Outcomes from 8 years of cervical cancer screening at a rural screen-and-treat site in northern Tanzania.

Journal article Int J Gynaecol Obstet · February 2023 OBJECTIVE: To examine screening outcomes for a rural screen-and-treat site as well as the referral completion rate, outreach programming, and screening costs. METHODS: A retrospective cross-sectional analysis of demographic information and screening outcom ... Full text Link to item Cite

Pediatric cancer outcomes after the implementation of a residential hostel in Tanzania.

Journal article Pediatr Blood Cancer · October 2022 BACKGROUND: A large survival disparity exists for pediatric cancer patients in low- and middle-income countries compared with high-income countries. A variety of factors contribute to this gap, including late-stage disease at presentation, high rates of ab ... Full text Link to item Cite

Factors contributing to delayed childhood cancer care in low- and middle-income countries: A systematic review protocol.

Journal article Pediatr Blood Cancer · May 2022 BACKGROUND: Significant disparities exist for timely access to cancer care for children, with the highest disparities in low- and middle-income countries (LMICs). This study aims to conduct a systematic review that identifies the factors contributing to de ... Full text Link to item Cite

Assessing the cost and economic impact of tertiary-level pediatric cancer care in Tanzania.

Journal article PLoS One · 2022 BACKGROUND: Worldwide, an estimated 400,000 children develop cancer each year. The bulk of the mortalities from these cases occur in low-and-middle-income countries (LMICs). In Sub-Saharan Africa, there is a tremendous need to strengthen the capacity of he ... Full text Link to item Cite

Caregiver Acceptability of Mobile Phone Use for Pediatric Cancer Care in Tanzania: Cross-sectional Questionnaire Study.

Journal article JMIR Pediatr Parent · December 8, 2021 BACKGROUND: There is a 60% survival gap between children diagnosed with cancer in low- and middle-income countries (LMICs) and those in high-income countries. Low caregiver knowledge about childhood cancer and its treatment results in presentation delays a ... Full text Link to item Cite

Parental limited English proficiency in pediatric stem cell transplantation: Clinical impact and health care utilization.

Journal article Pediatr Blood Cancer · September 2021 BACKGROUND: Limited English proficiency (LEP) is associated with adverse clinical outcomes. The clinical impact of LEP in hematopoietic stem cell transplant (HSCT) has not been studied. The objectives of this study were to compare HSCT outcomes and health ... Full text Link to item Cite

Integration of cancer registry and electronic health record data to construct a childhood cancer survivorship cohort, facilitate risk stratification for late effects, and assess appropriate follow-up care.

Journal article Pediatr Blood Cancer · June 2021 BACKGROUND: This retrospective study harnessed an institutional cancer registry to construct a childhood cancer survivorship cohort, integrate electronic health record (EHR) and geospatial data to stratify survivors based on late-effect risk, analyze follo ... Full text Link to item Cite

The cost-effectiveness of treating childhood cancer in 4 centers across sub-Saharan Africa.

Journal article Cancer · March 1, 2021 BACKGROUND: The treatment of childhood cancer often is assumed to be costly in African settings, thereby limiting advocacy and policy efforts. The authors determined the cost and cost-effectiveness of maintaining childhood cancer centers across 4 hospitals ... Full text Link to item Cite

Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).

Journal article J Clin Oncol · March 1, 2021 PURPOSE: SJMB03 (ClinicalTrials.gov identifier: NCT00085202) was a phase III risk-adapted trial that aimed to determine the frequency and clinical significance of biological variants and genetic alterations in medulloblastoma. PATIENTS AND METHODS: Patient ... Full text Link to item Cite

Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma.

Journal article J Clin Oncol · March 1, 2021 PURPOSE: We sought to investigate clinical outcomes of relapsed medulloblastoma and to compare molecular features between patient-matched diagnostic and relapsed tumors. METHODS: Children and infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00 ... Full text Link to item Cite

Caregiver Acceptability of Mobile Phone Use for Pediatric Cancer Care in Tanzania: Cross-sectional Questionnaire Study (Preprint)

Journal article · February 16, 2021 BACKGROUNDThere is a 60% survival gap between children diagnosed with cancer in low- and middle-income countries (LMICs) and those in high-income countries. Low caregiver knowledge about ... Full text Cite

Capturing Acquired Wisdom, Enabling Healthful Aging, and Building Multinational Partnerships Through Senior Global Health Mentorship.

Journal article Glob Health Sci Pract · December 23, 2020 The undeniable benefit of mentorship by experience senior mentors can meaningfully increase the breadth of their experience and contributions to society as well as address the dire inequality in global health. This model captures wisdom lost to retirement, ... Full text Link to item Cite

Delays Experienced by Patients With Pediatric Cancer During the Health Facility Referral Process: A Study in Northern Tanzania.

Journal article JCO Glob Oncol · November 2020 PURPOSE: It is estimated that 50%-80% of patients with pediatric cancer in sub-Saharan Africa present at an advanced stage. Delays can occur at any time during the care-seeking process from symptom onset to treatment initiation. Referral delay, the time fr ... Full text Link to item Cite

Cancer incidence and treatment utilization patterns at a regional cancer center in Tanzania from 2008-2016: Initial report of 2,772 cases.

Journal article Cancer Epidemiol · August 2020 PURPOSE: To describe cancer incidence and treatment utilization patterns at the regional cancer referral center for the Lake Zone of northwestern Tanzania from 2008 to 2016. METHODS: This descriptive, retrospective study reviewed all cancer cases recorded ... Full text Link to item Cite

Using digital health to facilitate compliance with standardized pediatric cancer treatment guidelines in Tanzania: protocol for an early-stage effectiveness-implementation hybrid study.

Journal article BMC Cancer · March 29, 2020 BACKGROUND: In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make ... Full text Link to item Cite

The whole-genome landscape of Burkitt lymphoma subtypes.

Journal article Blood · November 7, 2019 Burkitt lymphoma (BL) is an aggressive, MYC-driven lymphoma comprising 3 distinct clinical subtypes: sporadic BLs that occur worldwide, endemic BLs that occur predominantly in sub-Saharan Africa, and immunodeficiency-associated BLs that occur primarily in ... Full text Link to item Cite

Pediatric Cancer in Northern Tanzania: Evaluation of Diagnosis, Treatment, and Outcomes.

Journal article J Glob Oncol · September 2018 PURPOSE: The majority of new diagnoses of pediatric cancer are made in resource-poor countries, where survival rates range from 5% to 25% compared with 80% in high-resource countries. Multiple factors, including diagnostic and treatment capacities and comp ... Full text Link to item Cite

Qualitative Analysis of Palliative Care for Pediatric Patients With Cancer at Bugando Medical Center: An Evaluation of Barriers to Providing End-of-Life Care in a Resource-Limited Setting.

Journal article J Glob Oncol · July 2018 Purpose Palliative care remains an urgent, neglected need in the developing world. Global disparities in end-of-life care for children, such as those with advanced cancers, result from barriers that are complex and largely unstudied. This study describes t ... Full text Open Access Link to item Cite

Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies.

Journal article J Exp Med · August 7, 2017 A subset of characterized HIV-1 broadly neutralizing antibodies (bnAbs) are polyreactive with additional specificities for self-antigens and it has been proposed immunological tolerance may present a barrier to their participation in protective humoral imm ... Full text Link to item Cite

Immunological tolerance as a barrier to protective HIV humoral immunity.

Journal article Curr Opin Immunol · August 2017 HIV-1 infection typically eludes antibody control by our immune system and is not yet prevented by a vaccine. While many viral features contribute to this immune evasion, broadly neutralizing antibodies (bnAbs) against HIV-1 are often autoreactive and it h ... Full text Link to item Cite

Validation and Quality Assessment of the Kilimanjaro Cancer Registry.

Journal article J Glob Oncol · December 2016 PURPOSE: Global cancer burden has increasingly shifted to low- and middle-income countries and is particularly pronounced in Africa. There remains a lack of comprehensive cancer information as a result of limited cancer registry development. In Moshi, Tanz ... Full text Open Access Link to item Cite

Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.

Journal article Cell Rep · August 2, 2016 Chikungunya virus (CHIKV) and related alphaviruses cause epidemics of acute and chronic musculoskeletal disease. To investigate the mechanisms underlying the failure of immune clearance of CHIKV, we studied mice infected with an attenuated CHIKV strain (18 ... Full text Link to item Cite

PEDIATRIC ONCOLOGY IN THE LAKE REGION OF TANZANIA: EVALUATION OF CLINICAL DIAGNOSIS, TREATMENT AND OUTCOMES

Journal article PEDIATRIC BLOOD & CANCER · November 1, 2015 Link to item Cite

A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.

Journal article PLoS One · 2015 Diffuse intrinsic pontine gliomas (DIPGs) represent a particularly lethal type of pediatric brain cancer with no effective therapeutic options. Our laboratory has previously reported the development of genetically engineered DIPG mouse models using the RCA ... Full text Open Access Link to item Cite

Molecular variants and mutations in medulloblastoma.

Journal article Pharmgenomics Pers Med · 2014 Medulloblastoma is the commonest malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved outcomes in recent years, but patients are frequently left with devastating neurocognitive and other sequelae following s ... Full text Open Access Link to item Cite

Central nervous system tumor distribution at a tertiary referral center in Uganda.

Journal article World Neurosurg · 2014 Full text Link to item Cite

Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology.

Journal article Pediatr Res · January 2014 Diffuse intrinsic pontine glioma (DIPG) is a high-grade glioma that originates in the pons and is seen exclusively in children. Despite numerous efforts to improve treatment, DIPG remains incurable with 90% of children dying within 2 y of diagnosis, making ... Full text Link to item Cite

The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.

Journal article Autoimmunity · March 2013 The formation of antibodies against double-stranded (ds)DNA is considered to be the serologic hallmark of systemic lupus erythematosus (SLE) and anti-dsDNA antibodies play an important role in the pathogenesis of the disease. Anti-dsDNA antibodies from lup ... Full text Link to item Cite

Predictors of relapse during treatment and treatment completion among marijuana-dependent adolescents in an intensive outpatient substance abuse program.

Journal article Subst Abus · March 2004 The present study assessed possible predictors of relapse while in treatment and treatment completion among marijuana-dependent adolescents (N = 59) in an intensive outpatient substance abuse treatment program. Comorbid depression was associated with an in ... Full text Link to item Cite

Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4.

Journal article J Immunol · April 15, 2001 To explore an approach for death receptor targeting in cancer, we developed murine mAbs to human death receptor 4 (DR4). The mAb 4H6 (IgG1) competed with Apo2L/TNF-related apoptosis-inducing ligand (DR4's ligand) for binding to DR4, whereas mAb 4G7 (IgG2a) ... Full text Link to item Cite