Kuo Du

Journal Article JCI Insight · May 19, 2026 Aging drives systemic metabolic dysfunction (SMD) and increases the risk of chronic illnesses such as metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD). However, mechanisms that connect aging to multi-organ d ... Full text Link to item Cite

Redefining senescence through hepatocyte fate changes in liver diseases.

Journal Article Trends Endocrinol Metab · April 2026 Hepatocyte senescence is increasingly recognized as a key contributor to liver pathophysiology. While traditionally viewed as a state of permanent growth arrest, hepatocyte senescence is now understood to be more dynamic and potentially reversible, particu ... Full text Link to item Cite

Age and sex influence transcriptomic responses to statin therapy that control liver aging during systemic metabolic dysfunction.

Journal Article Hepatology · February 2, 2026 BACKGROUND AND AIMS: Older age increases susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD), but whether it impacts response to therapies, and how the therapies impact regulators of biological aging, are poorly understood. S ... Full text Link to item Cite

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Recent Grants

Targeting Hepatocyte Senescence to Improve NAFLD

ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029

A multidisciplinary study of biological disparities in NASH progression and response to statins to inform personalized liver cancer chemoprevention in NAFLD

ResearchPostdoctoral Associate · Awarded by Department of Defense · 2020 - 2025

Hippo-Yap Pathway, Ferroptosis of Hepatic Stellate Cells and Liver Fibrosis

ResearchPI-Fellow · Awarded by American Association for the Study of Liver Diseases · 2021 - 2024

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Education

University of Kansas · 2017 Ph.D.