Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Kansas 2017
• Research
• 

  Selected Grants

  • Hippo-Yap Pathway, Ferroptosis of Hepatic Stellate Cells and Liver Fibrosis awarded by American Association for the Study of Liver Diseases 2021 - 2024
  • A multidisciplinary study of biological disparities in NASH progression and response to statins to inform personalized liver cancer chemoprevention in NAFLD awarded by Department of Defense 2020 - 2024
  • Pathophysiological Role of Glutaminolysis in Human NAFLD Progression awarded by American Association for the Study of Liver Diseases 2018 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Du, Kuo, Seh Hoon Oh, Rajesh K. Dutta, Tianai Sun, Wen-Hsuan Yang, Jen-Tsan Chi, and Anna Mae Diehl. “Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.” Liver Int 41, no. 9 (September 2021): 2214–27. https://doi.org/10.1111/liv.14945.
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    • Nguyen, Nga T., Kuo Du, Jephte Y. Akakpo, David S. Umbaugh, Hartmut Jaeschke, and Anup Ramachandran. “Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.” Toxicol Lett 338 (March 1, 2021): 21–31. https://doi.org/10.1016/j.toxlet.2020.12.005.
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    • Hyun, Jeongeun, Zhaoli Sun, Ali Reza Ahmadi, Sushant Bangru, Ullas V. Chembazhi, Kuo Du, Tianyi Chen, et al. “Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.” J Clin Invest 130, no. 4 (April 1, 2020): 2129–45. https://doi.org/10.1172/JCI132691.
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    • Liu, Xue-Jing, Li Xie, Kuo Du, Chang Liu, Ning-Ping Zhang, Chen-Jian Gu, Ying Wang, et al. “Succinate-GPR-91 receptor signalling is responsible for nonalcoholic steatohepatitis-associated fibrosis: Effects of DHA supplementation.” Liver Int 40, no. 4 (April 2020): 830–43. https://doi.org/10.1111/liv.14370.
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    • Du, Kuo, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, et al. “Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.” Cell Mol Gastroenterol Hepatol 10, no. 1 (2020): 1–21. https://doi.org/10.1016/j.jcmgh.2019.12.006.
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    • Jewell, Mark L., Jason R. Gibson, Cynthia D. Guy, Jeongeun Hyun, Kuo Du, Seh-Hoon Oh, Richard T. Premont, et al. “Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.” The American Journal of Pathology 190, no. 1 (January 2020): 93–107. https://doi.org/10.1016/j.ajpath.2019.09.018.
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    • Du, Kuo, Anup Ramachandran, James L. Weemhoff, Benjamin L. Woolbright, Andrew H. Jaeschke, Xiaojuan Chao, Wen-Xing Ding, and Hartmut Jaeschke. “Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.” Arch Toxicol 93, no. 1 (January 2019): 163–78. https://doi.org/10.1007/s00204-018-2331-8.
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    • Du, Kuo, Anup Ramachandran, Mitchell R. McGill, Abdellah Mansouri, Tarik Asselah, Anwar Farhood, Benjamin L. Woolbright, Wen-Xing Ding, and Hartmut Jaeschke. “Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.” Food Chem Toxicol 108, no. Pt A (October 2017): 339–50. https://doi.org/10.1016/j.fct.2017.08.020.
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    • Duan, Luqi, John S. Davis, Benjamin L. Woolbright, Kuo Du, Mala Cahkraborty, James Weemhoff, Hartmut Jaeschke, and Mohammed Bourdi. “Corrigendum to "Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J" [Food and Chem. Toxicol. 98 (Part B) (2016) 107-118].” Food Chem Toxicol 103 (May 2017): 289. https://doi.org/10.1016/j.fct.2017.03.032.
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    • Bhushan, Bharat, Hemantkumar Chavan, Prachi Borude, Yuchao Xie, Kuo Du, Mitchell R. McGill, Margitta Lebofsky, Hartmut Jaeschke, Partha Krishnamurthy, and Udayan Apte. “Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.” Toxicol Sci 155, no. 2 (February 2017): 363–78. https://doi.org/10.1093/toxsci/kfw213.
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    • Du, Kuo, Anwar Farhood, and Hartmut Jaeschke. “Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.” Arch Toxicol 91, no. 2 (February 2017): 761–73. https://doi.org/10.1007/s00204-016-1692-0.
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    • Du, Kuo, Anup Ramachandran, James L. Weemhoff, Hemantkumar Chavan, Yuchao Xie, Partha Krishnamurthy, and Hartmut Jaeschke. “Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.” Toxicol Sci 154, no. 2 (December 2016): 214–26. https://doi.org/10.1093/toxsci/kfw158.
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    • Du, Kuo, Anup Ramachandran, and Hartmut Jaeschke. “Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential.” Redox Biol 10 (December 2016): 148–56. https://doi.org/10.1016/j.redox.2016.10.001.
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    • Duan, Luqi, John S. Davis, Benjamin L. Woolbright, Kuo Du, Mala Cahkraborty, James Weemhoff, Hartmut Jaeschke, and Mohammed Bourdi. “Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.” Food Chem Toxicol 98, no. Pt B (December 2016): 107–18. https://doi.org/10.1016/j.fct.2016.10.021.
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    • Ni, Hong-Min, Mitchell R. McGill, Xiaojuan Chao, Kuo Du, Jessica A. Williams, Yuchao Xie, Hartmut Jaeschke, and Wen-Xing Ding. “Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.” J Hepatol 65, no. 2 (August 2016): 354–62. https://doi.org/10.1016/j.jhep.2016.04.025.
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    • Du, Kuo, and Hartmut Jaeschke. “Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?” World J Gastroenterol 22, no. 11 (March 21, 2016): 3302–4. https://doi.org/10.3748/wjg.v22.i11.3302.
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    • Du, Kuo, Mitchell R. McGill, Yuchao Xie, and Hartmut Jaeschke. “Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.” Food Chem Toxicol 86 (December 2015): 253–61. https://doi.org/10.1016/j.fct.2015.10.016.
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    • McGill, Mitchell R., Kuo Du, James L. Weemhoff, and Hartmut Jaeschke. “Critical review of resveratrol in xenobiotic-induced hepatotoxicity.” Food Chem Toxicol 86 (December 2015): 309–18. https://doi.org/10.1016/j.fct.2015.11.003.
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    • Xie, Yuchao, Mitchell R. McGill, Kuo Du, Kenneth Dorko, Sean C. Kumer, Timothy M. Schmitt, Wen-Xing Ding, and Hartmut Jaeschke. “Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.” Toxicol Appl Pharmacol 289, no. 2 (December 1, 2015): 213–22. https://doi.org/10.1016/j.taap.2015.09.022.
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    • Jaeschke, Hartmut, and Kuo Du. “Benzyl Alcohol: A novel treatment for acetaminophen overdose?” Hepatology 62, no. 5 (November 2015): 1641–42. https://doi.org/10.1002/hep.27786.
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    • Du, Kuo, Mitchell R. McGill, Yuchao Xie, Mary Lynn Bajt, and Hartmut Jaeschke. “Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.” Food Chem Toxicol 81 (July 2015): 62–70. https://doi.org/10.1016/j.fct.2015.04.014.
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    • McGill, Mitchell R., Kuo Du, Yuchao Xie, Mary Lynn Bajt, Wen-Xing Ding, and Hartmut Jaeschke. “The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.” Xenobiotica 45, no. 5 (May 2015): 442–49. https://doi.org/10.3109/00498254.2014.986250.
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    • Du, Kuo, Yuchao Xie, Mitchell R. McGill, and Hartmut Jaeschke. “Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.” Expert Opin Drug Metab Toxicol 11, no. 11 (2015): 1769–79. https://doi.org/10.1517/17425255.2015.1071353.
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    • Du, Kuo, C David Williams, Mitchell R. McGill, and Hartmut Jaeschke. “Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.” Toxicol Appl Pharmacol 281, no. 1 (November 15, 2014): 58–66. https://doi.org/10.1016/j.taap.2014.09.002.
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    • Du, Kuo, C David Williams, Mitchell R. McGill, Yuchao Xie, Anwar Farhood, Mathieu Vinken, and Hartmut Jaeschke. “The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.” Toxicol Appl Pharmacol 273, no. 3 (December 15, 2013): 484–91. https://doi.org/10.1016/j.taap.2013.09.010.
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    • Ni, Hong-Min, Kuo Du, Min You, and Wen-Xing Ding. “Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity.” Am J Pathol 183, no. 6 (December 2013): 1815–25. https://doi.org/10.1016/j.ajpath.2013.08.011.
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  • Conference Papers

    • Du, Kuo, Jeongeun Hyun, Richard T. Premont, Steve S. Choi, Gregory A. Michelotti, Marzena Swiderska-Syn, George D. Dalton, et al. “Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.” In Gastroenterology, 154:1465-1479.e13, 2018. https://doi.org/10.1053/j.gastro.2017.12.022.
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