Kuo Du

Journal Article J Hepatol · January 2026 Obesity, metabolic syndrome, and aging are major contributors to the rising global burden of chronic liver diseases. Among these, aging remains an often underrecognised driver that intersects with other metabolic and environmental insults to exacerbate liv ... Full text Link to item Cite

Redefining senescence through hepatocyte fate changes in liver diseases.

Journal Article Trends Endocrinol Metab · August 28, 2025 Hepatocyte senescence is increasingly recognized as a key contributor to liver pathophysiology. While traditionally viewed as a state of permanent growth arrest, hepatocyte senescence is now understood to be more dynamic and potentially reversible, particu ... Full text Link to item Cite

WSTF nuclear autophagy regulates chronic but not acute inflammation.

Journal Article Nature · August 2025 Acute inflammation is an essential response that our bodies use to combat infections1. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmu ... Full text Open Access Link to item Cite

View All Publications

Recent Grants

Targeting Hepatocyte Senescence to Improve NAFLD

ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029

A multidisciplinary study of biological disparities in NASH progression and response to statins to inform personalized liver cancer chemoprevention in NAFLD

ResearchPostdoctoral Associate · Awarded by Department of Defense · 2020 - 2025

Hippo-Yap Pathway, Ferroptosis of Hepatic Stellate Cells and Liver Fibrosis

ResearchPI-Fellow · Awarded by American Association for the Study of Liver Diseases · 2021 - 2024

View All Grants

Education, Training & Certifications

University of Kansas · 2017 Ph.D.