Kuo Du

Conference Hepatology · June 1, 2023 BACKGROUND AND AIMS: Liver fibrosis results from the accumulation of myofibroblasts (MFs) derived from quiescent HSCs, and yes-associated protein (YAP) controls this state transition. Although fibrosis is also influenced by HSC death and senescence, whethe ... Full text Open Access Link to item Cite

SMOOTHENED DEPENDENT HEDGEHOG SIGNALING ENSURES METABOLIC CONTROL BY MAINTAINING AUTOPHAGY AND PROTECTING AGAINST FERROPTOSIS

Conference GASTROENTEROLOGY · May 2023 Link to item Cite

Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease.

Conference Cell Mol Gastroenterol Hepatol · 2023 BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration. We a ... Full text Link to item Cite

PRE-TEENS EXPOSED PRENATALLY TO MATERNAL OBESITY EXHIBIT PERSISTENT DNA METHYLATION CHANGES THAT ASSOCIATE WITH METABOLIC ABNORMALITIES, INCLUDING HIGH LIVER FAT

Conference HEPATOLOGY · October 2022 Link to item Cite

HEPATOCYTE SPECIFIC DELETION OF caspase2 PROTECTS FROM HEPATIC STEATOSIS AND IMPROVES SYSTEMIC INSULIN RESISTANCE BY PROMOTING GLYCOLYSIS AND MITOCHONDRIAL BIOGENESIS

Conference HEPATOLOGY · October 2022 Link to item Cite

Aging reduces liver resiliency by dysregulating Hedgehog signaling.

Conference Aging Cell · February 2022 Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with critical m ... Full text Link to item Cite

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells and protects against liver fibrosis

Conference · 2019 Background and Aims Liver fibrosis develops in the context of excessive oxidative stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate cells (HSCs). Ferroptosis is a type of regulated cell death that can be ca ... Full text Cite

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Conference Gastroenterology · April 2018 BACKGROUND & AIMS: Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activating Yes ... Full text Link to item Cite