Scholars@Duke
Madan Mohan Kwatra

Madan Mohan Kwatra

Associate Professor in Anesthesiology
Anesthesiology
madan.kwatra@duke.edu
Box 3094 Med Ctr, Durham, NC 27710
146 Sands Bldg, Durham, NC 27710

Featured Works

Delirium in older persons.

Journal article N Engl J Med · June 8, 2006 Featured Publication Link to item Cite

Prevention of atrial fibrillation following cardiac surgery.

Journal article JAMA · May 17, 2006 Featured Publication Full text Link to item Cite

Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.

Journal article Cancer Chemother Pharmacol · December 2005 Featured Publication Substance P receptor (SPR), a G protein-coupled receptor (GPCR), is found in human glioblastomas, and has been implicated in their growth. Consistent with a role for SPR in cell growth, activation of SPR in U373 MG human glioblastoma cells leads to the pho ... Full text Link to item Cite

G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta.

Journal article J Mol Cell Cardiol · February 2005 Featured Publication Cardiac G alpha(q)-coupled receptors (such as endothelin, angiotensin, and alpha1-adrenergic receptors) mediate cardiac inotropy and chronotropy, as well as the development of hypertrophy. These receptors signal through protein kinase C (PKC), a family of ... Full text Link to item Cite

Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.

Journal article Anesthesiology · February 2003 Featured Publication BACKGROUND: Cardiopulmonary bypass (CPB) has been implicated in the development of organ injury associated with cardiac surgery. At the molecular level, CPB is accompanied by a pronounced proinflammatory response including an increase in plasma interleukin ... Full text Link to item Cite

Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.

Journal article Mol Pharmacol · May 1999 Featured Publication Substance P receptor (SPR), which plays a key role in pain transmission, is known to undergo rapid agonist-dependent desensitization and internalization. The present study shows that human SPR undergoes agonist-dependent phosphorylation in intact cells. Im ... Link to item Cite

Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o).

Journal article FEBS Lett · May 29, 1998 Featured Publication Substance P receptor (SPR) stably expressed in Chinese hamster ovary (CHO) cells stimulates at least three second messenger systems including phosphoinositide hydrolysis, cyclic AMP (cAMP) formation, and arachidonic acid release. Whether these second messe ... Full text Link to item Cite

Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes.

Journal article Biochemistry · February 3, 1998 Featured Publication G protein-coupled receptor kinases (GRKs) phosphorylate agonist-occupied G protein-coupled receptors (GPCRs), resulting in GPCR desensitization. GRK2 is one of the better studied of the six known GRKs and phosphorylates several GPCRs. In a previous study, ... Full text Link to item Cite

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.

Journal article J Biol Chem · May 5, 1993 Featured Publication The agonist-occupied forms of several G-protein-coupled receptors that modulate the activity of adenylycyclase via Gs (e.g. beta 2-adrenergic) or Gi (e.g. alpha 2-adrenergic and cardiac muscarinic) are phosphorylated by beta-adrenergic receptor kinases (be ... Link to item Cite

The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization.

Journal article Biochim Biophys Acta · March 16, 1992 Featured Publication To examine the role of the ligand binding domain of epidermal growth factor receptor in its dimerization, we studied the dimerization of a truncated form of the receptor that resembles v-erbB in that it lacks a ligand binding domain. Receptor dimerization ... Full text Link to item Cite

The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor.

Journal article Mol Pharmacol · May 1989 Featured Publication Recently we showed that the chick heart muscarinic acetylcholine receptor is a phosphoprotein in intact cells and that treatment with agonists results in a striking increase in receptor phosphorylation [J. Biol. Chem. 261:12429-12432 (1986)]. Furthermore, ... Link to item Cite

Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.

Journal article J Biol Chem · December 5, 1987 Featured Publication We have determined whether the process of agonist-mediated phosphorylation of the muscarinic receptor correlates with the process of muscarinic receptor desensitization in chick cardiac tissue. Exposure of ventricular slices to the agonist carbachol under ... Link to item Cite

Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.

Journal article J Biol Chem · September 25, 1986 Featured Publication We have tested the possibility that regulation of cardiac muscarinic receptor function may involve receptor phosphorylation. Chick heart muscarinic receptors were purified from relatively small amounts of tissue to near homogeneity using a three-step chrom ... Link to item Cite