Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Michigan, Ann Arbor 1982
  • Ph.D., Cornell University 1982
• 

  Duke Appointment History

  • Assistant Research Professor of Cell Biology, Cell Biology, Basic Science Departments 1998 - 2003
• Recognition
• 

  In the News

  • MAY 28, 2020

    New Molecule Stops Drug Cravings in Mice With Fewer Side Effects
• Research
• 

  Selected Grants

  • Exploiting Biased Agonism at the Ghrelin Receptor (GHSR 1a) for Opioid Addiction awarded by National Institutes of Health 2020 - 2023
  • Managing L-­DOPA Induced Dyskinesias by Targeting Dopamine D1 Receptor Biased Signaling awarded by Michael J. Fox Foundation for Parkinson's Research 2019 - 2022
  • A novel functionally selective drug for the treatment of cocaine abuse by antagonism of the beta-arrestin signaling arm of the Ghrelin Receptor awarded by National Institutes of Health 2020 - 2021
  • Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders awarded by Sanford Burnham Prebys Medical Discovery Institute 2019 - 2021
  • Leveraging Functional Selectivity in the Neurotensin Receptor 1-Mediated Treatment of Addiction awarded by National Institutes of Health 2019 - 2021
  • Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior awarded by National Institutes of Health 2017 - 2020
  • Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health 2005 - 2020
  • Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy awarded by National Institutes of Health 2013 - 2019
  • Biased Agonism at Neurotensin Receptor 1 for the Treatment of Methamphetamine Addiction awarded by National Institutes of Health 2017 - 2019
  • Drug Abuse: Discovering Ligands for Pertinent GPCRs awarded by National Institutes of Health 2010 - 2019
  • A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes awarded by National Institutes of Health 2015 - 2018
  • Screening and identification of beta-arrestin biased dopamine receptor ligands for PD symptom therapy. awarded by Michael J. Fox Foundation for Parkinson's Research 2016
  • Beta-arrestin Regulation of Ghrelin Signaling in Modulating Addictive Behavior awarded by National Institutes of Health 2014 - 2016
  • Novel high-throughput screening for modifiers of TorsinA pathology awarded by National Institutes of Health 2013 - 2015
  • A Cancer Rainbow Mouse for the Simultaneous Assessment of Multiple Oncogenes awarded by National Institutes of Health 2012 - 2015
  • Discovering Ligands for a5-a3-b4 Nicotinic Acetylcholine Receptors. awarded by National Institutes of Health 2010 - 2014
  • Small molecule screen to enhance epithelial repair awarded by National Institutes of Health 2011 - 2012
  • Small Molecule Agonsists for the Neurotensin 1 Receptor awarded by National Institutes of Health 2009 - 2012
  • Drug Abuse: Discovering Ligands for Pertinent GPCRs awarded by National Institutes of Health 2006 - 2010
  • Innovative Assays for Oncogenic Hedgehog Signaling awarded by National Institutes of Health 2006 - 2010
  • Dopamine Receptors: Characterization And Regulation awarded by National Institutes of Health 1983 - 2008
  • Molecular fingerprinting of GPCR ligands in Cancer awarded by National Institutes of Health 2004 - 2006
  • Zeiss LSM510 META confocal-fluorescence spectroscopy awarded by National Institutes of Health 2003 - 2004
  • Same awarded by National Institutes of Health 1999 - 2004
  • Mechanisms Of Beta2-Adrenergic Receptor Internalization awarded by National Institutes of Health 1996 - 1999
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Slosky, Lauren M., Marc G. Caron, and Lawrence S. Barak. “Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.” Trends Pharmacol Sci 42, no. 4 (April 2021): 283–99. https://doi.org/10.1016/j.tips.2020.12.005.
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    • Monroe, Tanner O., Melanie E. Garrett, Maria Kousi, Ramona M. Rodriguiz, Sungjin Moon, Yushi Bai, Steven C. Brodar, et al. “PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.” Nat Commun 11, no. 1 (November 19, 2020): 5903. https://doi.org/10.1038/s41467-020-19637-5.
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    • Slosky, Lauren M., Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, et al. “β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.” Cell 181, no. 6 (June 11, 2020): 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053.
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    • Boone, Peter G., Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, et al. “A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.” Nat Commun 10, no. 1 (December 2, 2019): 5490. https://doi.org/10.1038/s41467-019-13330-y.
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    • Pinkerton, Anthony B., Satyamaheshwar Peddibhotla, Fusayo Yamamoto, Lauren M. Slosky, Yushi Bai, Patrick Maloney, Paul Hershberger, et al. “Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.” J Med Chem 62, no. 17 (September 12, 2019): 8357–63. https://doi.org/10.1021/acs.jmedchem.9b00340.
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    • Toth, Krisztian, Karim Nagi, Lauren M. Slosky, Lauren Rochelle, Caroline Ray, Suneet Kaur, Sudha K. Shenoy, Marc G. Caron, and Larry S. Barak. “Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs.” Acs Pharmacol Transl Sci 2, no. 4 (August 9, 2019): 230–46. https://doi.org/10.1021/acsptsci.9b00018.
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    • Caron, Marc G., and Lawrence S. Barak. “A Brief History of the β-Arrestins.” Methods Mol Biol 1957 (2019): 3–8. https://doi.org/10.1007/978-1-4939-9158-7_1.
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    • Toth, Krisztian, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter Boone, Lan Mao, Dennis Abraham, Marc G. Caron, and Lawrence S. Barak. “Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.” Synapse 72, no. 1 (January 2018). https://doi.org/10.1002/syn.22012.
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    • Fakhouri, Lara, Christopher D. Cook, Mohammed H. Al-Huniti, Linda M. Console-Bram, Dow P. Hurst, Michael B. S. Spano, Daniel J. Nasrallah, et al. “Design, synthesis and biological evaluation of GPR55 agonists.” Bioorg Med Chem 25, no. 16 (August 15, 2017): 4355–67. https://doi.org/10.1016/j.bmc.2017.06.016.
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    • Le Gonidec, Sophie, Carline Chaves-Almagro, Yushi Bai, Hye Jin Kang, Allyson Smith, Estelle Wanecq, Xi-Ping Huang, et al. “Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.” Faseb J 31, no. 6 (June 2017): 2507–19. https://doi.org/10.1096/fj.201601074R.
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    • Snyder, Joshua C., Lauren K. Rochelle, Caroline Ray, Thomas F. Pack, Cheryl B. Bock, Veronica Lubkov, H Kim Lyerly, Alan S. Waggoner, Larry S. Barak, and Marc G. Caron. “Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.” J Biol Chem 292, no. 17 (April 28, 2017): 7208–22. https://doi.org/10.1074/jbc.M116.756635.
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    • Ray, Caroline, Erik J. Soderblom, Yushi Bai, F Ivy Carroll, Marc G. Caron, and Larry S. Barak. “Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands.” Acs Chem Biol 12, no. 3 (March 17, 2017): 702–14. https://doi.org/10.1021/acschembio.6b01117.
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    • Mook, Robert A., Xiu-Rong Ren, Jiangbo Wang, Hailan Piao, Larry S. Barak, H. Kim Lyerly, and Wei Chen. “Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.” Bioorg Med Chem 25, no. 6 (March 15, 2017): 1804–16. https://doi.org/10.1016/j.bmc.2017.01.046.
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    • Barak, Larry S., Yushi Bai, Sean Peterson, Tama Evron, Nikhil M. Urs, Satyamaheshwar Peddibhotla, Michael P. Hedrick, et al. “ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.” Acs Chem Biol 11, no. 7 (July 15, 2016): 1880–90. https://doi.org/10.1021/acschembio.6b00291.
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    • Meza-Aviña, Maria Elena, Mary A. Lingerfelt, Linda M. Console-Bram, Thomas F. Gamage, Haleli Sharir, Kristen E. Gettys, Dow P. Hurst, et al. “Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.” Bioorg Med Chem Lett 26, no. 7 (April 1, 2016): 1827–30. https://doi.org/10.1016/j.bmcl.2016.02.030.
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    • Snyder, Joshua C., Thomas F. Pack, Lauren K. Rochelle, Subhasish K. Chakraborty, Ming Zhang, Andrew W. Eaton, Yushi Bai, et al. “A rapid and affordable screening platform for membrane protein trafficking.” Bmc Biol 13 (December 17, 2015): 107. https://doi.org/10.1186/s12915-015-0216-3.
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    • Ren, X. R., J. Wang, T. Osada, R. A. Mook, M. A. Morse, L. S. Barak, H. K. Lyerly, and W. Chen. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res 17, no. 1 (December 2015): 528. https://doi.org/10.1186/s13058-015-0528-9.
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    • Mook, Robert A., Jiangbo Wang, Xiu-Rong Ren, Minyong Chen, Ivan Spasojevic, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.” Bioorg Med Chem 23, no. 17 (September 1, 2015): 5829–38. https://doi.org/10.1016/j.bmc.2015.07.001.
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    • Snyder, Joshua C., Lauren K. Rochelle, Sébastien Marion, H Kim Lyerly, Larry S. Barak, and Marc G. Caron. “Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.” J Cell Sci 128, no. 6 (March 15, 2015): 1230–40. https://doi.org/10.1242/jcs.166322.
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    • Ren, Xiu-Rong, Jiangbo Wang, Takuya Osada, Robert A. Mook, Michael A. Morse, Larry S. Barak, Herbert Kim Lyerly, and Wei Chen. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res 17 (February 15, 2015): 20. https://doi.org/10.1186/s13058-015-0528-9.
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    • Burczyk, Martina, Martin D. Burkhalter, Tamara Blätte, Sabrina Matysik, Marc G. Caron, Lawrence S. Barak, and Melanie Philipp. “Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.” Biochemistry 54, no. 3 (January 27, 2015): 765–75. https://doi.org/10.1021/bi501061h.
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    • Evron, Tama, Sean M. Peterson, Nikhil M. Urs, Yushi Bai, Lauren K. Rochelle, Marc G. Caron, and Larry S. Barak. “G Protein and β-arrestin signaling bias at the ghrelin receptor.” J Biol Chem 289, no. 48 (November 28, 2014): 33442–55. https://doi.org/10.1074/jbc.M114.581397.
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    • Tadokoro, Tomomi, Yang Wang, Larry S. Barak, Yushi Bai, Scott H. Randell, and Brigid L. M. Hogan. “IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells.” Proc Natl Acad Sci U S A 111, no. 35 (September 2, 2014): E3641–49. https://doi.org/10.1073/pnas.1409781111.
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    • Hershberger, Paul M., Michael P. Hedrick, Satyamaheshwar Peddibhotla, Arianna Mangravita-Novo, Palak Gosalia, Yujie Li, Wilson Gray, et al. “Imidazole-derived agonists for the neurotensin 1 receptor.” Bioorg Med Chem Lett 24, no. 1 (January 1, 2014): 262–67. https://doi.org/10.1016/j.bmcl.2013.11.026.
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    • Snyder, J. C., L. K. Rochelle, L. S. Barak, and M. G. Caron. “Correction: The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment.” Plos One 9, no. 1 (2014). https://doi.org/10.1371/annotation/7f83735d-53d4-42f3-b3b2-b05dd5db059c.
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    • Kotsikorou, Evangelia, Haleli Sharir, Derek M. Shore, Dow P. Hurst, Diane L. Lynch, Karla E. Madrigal, Susanne Heynen-Genel, et al. “Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.” Biochemistry 52, no. 52 (December 31, 2013): 9456–69. https://doi.org/10.1021/bi4008885.
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    • Barak, Larry S., Yushi Bai, Joshua C. Snyder, Jiangbo Wang, Wei Chen, and Marc G. Caron. “Triphenylmethane dye activation of beta-arrestin.” Biochemistry 52, no. 32 (August 13, 2013): 5403–14. https://doi.org/10.1021/bi400217r.
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    • Peddibhotla, Satyamaheshwar, Michael P. Hedrick, Paul Hershberger, Patrick R. Maloney, Yujie Li, Monika Milewski, Palak Gosalia, et al. “Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.” Acs Med Chem Lett 4, no. 9 (July 20, 2013): 846–51. https://doi.org/10.1021/ml400176n.
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    • Thakur, Ganesh A., Shama Bajaj, Carol Paronis, Yan Peng, Anna L. Bowman, Lawrence S. Barak, Marc G. Caron, Demon Parrish, Jeffrey R. Deschamps, and Alexandros Makriyannis. “Novel adamantyl cannabinoids as CB1 receptor probes.” J Med Chem 56, no. 10 (May 23, 2013): 3904–21. https://doi.org/10.1021/jm4000775.
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    • Snyder, Joshua C., Lauren K. Rochelle, H Kim Lyerly, Marc G. Caron, and Lawrence S. Barak. “Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network.” J Biol Chem 288, no. 15 (April 12, 2013): 10286–97. https://doi.org/10.1074/jbc.M112.447540.
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    • Dray, Cédric, Yassine Sakar, Claire Vinel, Daniele Daviaud, Bernard Masri, Luc Garrigues, Estelle Wanecq, et al. “The intestinal glucose-apelin cycle controls carbohydrate absorption in mice.” Gastroenterology 144, no. 4 (April 2013): 771–80. https://doi.org/10.1053/j.gastro.2013.01.004.
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    • Mook, Robert A., Minyong Chen, Jiuyi Lu, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Small molecule modulators of Wnt/β-catenin signaling.” Bioorg Med Chem Lett 23, no. 7 (April 1, 2013): 2187–91. https://doi.org/10.1016/j.bmcl.2013.01.101.
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    • Evron, T., N. M. Urs, L. Sutton, Y. Bai, M. G. Caron, and L. S. Barak. “β-arrestin Regulation of Ghrelin Signaling in modulating Addictive Behavior,” January 1, 2013, 184. https://doi.org/10.1016/B978-0-12-800044-1.00167-7.
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    • Lu, Jiuyi, Minyong Chen, Xiu-Rong Ren, Jiangbo Wang, H Kim Lyerly, Larry Barak, and Wei Chen. “Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.” Plos One 8, no. 5 (2013): e63353. https://doi.org/10.1371/journal.pone.0063353.
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    • Snyder, Joshua C., Lauren K. Rochelle, Larry S. Barak, and Marc G. Caron. “The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.” Plos One 8, no. 12 (2013): e84476. https://doi.org/10.1371/journal.pone.0084476.
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    • Wang, Jiangbo, Robert A. Mook, Jiuyi Lu, David M. Gooden, Anthony Ribeiro, Anchen Guo, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.” Bioorg Med Chem 20, no. 22 (November 15, 2012): 6751–57. https://doi.org/10.1016/j.bmc.2012.09.030.
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    • Wang, Jiangbo, Jiuyi Lu, Robert A. Mook, Min Zhang, Shengli Zhao, Larry S. Barak, Jonathan H. Freedman, H Kim Lyerly, and Wei Chen. “The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.” Toxicol Sci 128, no. 2 (August 2012): 517–23. https://doi.org/10.1093/toxsci/kfs165.
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    • Ren, Xiu-Rong, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Wenle Xia, Neil Spector, et al. “Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.” Breast Cancer Res 14, no. 3 (June 7, 2012): R89. https://doi.org/10.1186/bcr3204.
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    • Frankowski, Kevin J., Michael P. Hedrick, Palak Gosalia, Kelin Li, Shenghua Shi, David Whipple, Partha Ghosh, et al. “Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.” Acs Chem Neurosci 3, no. 3 (March 21, 2012): 221–36. https://doi.org/10.1021/cn200128x.
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    • Barak, Larry S., and Sean Peterson. “Modeling of bias for the analysis of receptor signaling in biochemical systems.” Biochemistry 51, no. 6 (February 14, 2012): 1114–25. https://doi.org/10.1021/bi201308s.
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    • Salahpour, Ali, Stefano Espinoza, Bernard Masri, Vincent Lam, Larry S. Barak, and Raul R. Gainetdinov. “BRET biosensors to study GPCR biology, pharmacology, and signal transduction.” Front Endocrinol (Lausanne) 3 (2012): 105. https://doi.org/10.3389/fendo.2012.00105.
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    • Espinoza, Stefano, Ali Salahpour, Bernard Masri, Tatyana D. Sotnikova, Mirko Messa, Larry S. Barak, Marc G. Caron, and Raul R. Gainetdinov. “Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.” Mol Pharmacol 80, no. 3 (September 2011): 416–25. https://doi.org/10.1124/mol.111.073304.
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    • Salahpour, Ali, and Larry S. Barak. “Visualizing receptor endocytosis and trafficking.” Methods Mol Biol 756 (2011): 311–23. https://doi.org/10.1007/978-1-61779-160-4_18.
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    • Wang, Jiangbo, Larry S. Barak, Robert A. Mook, and Wei Chen. “Glucocorticoid hedgehog agonists in neurogenesis.” Vitam Horm 87 (2011): 207–15. https://doi.org/10.1016/B978-0-12-386015-6.00030-5.
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    • Sotnikova, Tatyana D., Jean-Martin Beaulieu, Stefano Espinoza, Bernard Masri, Xiaodong Zhang, Ali Salahpour, Larry S. Barak, Marc G. Caron, and Raul R. Gainetdinov. “The dopamine metabolite 3-methoxytyramine is a neuromodulator.” Plos One 5, no. 10 (October 18, 2010): e13452. https://doi.org/10.1371/journal.pone.0013452.
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    • Zhao, Pingwei, Haleli Sharir, Ankur Kapur, Alan Cowan, Ellen B. Geller, Martin W. Adler, Herbert H. Seltzman, et al. “Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.” Mol Pharmacol 78, no. 4 (October 2010): 560–68. https://doi.org/10.1124/mol.110.066746.
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    • Chen, Wei, Minyong Chen, and Larry S. Barak. “Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.” Am J Physiol Gastrointest Liver Physiol 299, no. 2 (August 2010): G293–300. https://doi.org/10.1152/ajpgi.00005.2010.
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    • Wang, Jiangbo, Jiuyi Lu, Michael C. Bond, Minyong Chen, Xiu-Rong Ren, H Kim Lyerly, Larry S. Barak, and Wei Chen. “Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.” Proc Natl Acad Sci U S A 107, no. 20 (May 18, 2010): 9323–28. https://doi.org/10.1073/pnas.0910712107.
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    • Chen, Minyong, Jiangbo Wang, Jiuyi Lu, Michael C. Bond, Xiu-Rong Ren, H Kim Lyerly, Larry S. Barak, and Wei Chen. “The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.” Biochemistry 48, no. 43 (November 3, 2009): 10267–74. https://doi.org/10.1021/bi9009677.
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    • Kapur, Ankur, Pingwei Zhao, Haleli Sharir, Yushi Bai, Marc G. Caron, Larry S. Barak, and Mary E. Abood. “Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.” J Biol Chem 284, no. 43 (October 23, 2009): 29817–27. https://doi.org/10.1074/jbc.M109.050187.
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    • Philipp, Melanie, Gregory B. Fralish, Alison R. Meloni, Wei Chen, Alyson W. MacInnes, Lawrence S. Barak, and Marc G. Caron. “Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.” Mol Biol Cell 19, no. 12 (December 2008): 5478–89. https://doi.org/10.1091/mbc.e08-05-0448.
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    • Barak, Larry S., Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron, and Raul R. Gainetdinov. “Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.” Mol Pharmacol 74, no. 3 (September 2008): 585–94. https://doi.org/10.1124/mol.108.048884.
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    • Ryu, H., J. K. L. Walker, S. Kim, N. Koo, L. S. Barak, T. Noguchi, B. Y. Kang, and K. -. M. Kim. “Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation.” Br J Pharmacol 154, no. 5 (July 2008): 1035–46. https://doi.org/10.1038/bjp.2008.148.
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    • Shenoy, Sudha K., Larry S. Barak, Kunhong Xiao, Seungkirl Ahn, Magali Berthouze, Arun K. Shukla, Louis M. Luttrell, and Robert J. Lefkowitz. “Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.” J Biol Chem 282, no. 40 (October 5, 2007): 29549–62. https://doi.org/10.1074/jbc.M700852200.
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    • Marion, Sébastien, Gregory B. Fralish, Stéphane Laporte, Marc G. Caron, and Larry S. Barak. “N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.” J Biol Chem 282, no. 26 (June 29, 2007): 18937–44. https://doi.org/10.1074/jbc.M700090200.
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    • Marion, Sébastien, Robert H. Oakley, Kyeong-Man Kim, Marc G. Caron, and Larry S. Barak. “A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.” J Biol Chem 281, no. 5 (February 3, 2006): 2932–38. https://doi.org/10.1074/jbc.M508074200.
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    • Barak, Larry S., Jacqueline Gilchrist, Jeffrey M. Becker, and Kyeong-Man Kim. “Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.” Biochem Biophys Res Commun 339, no. 2 (January 13, 2006): 695–700. https://doi.org/10.1016/j.bbrc.2005.11.070.
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    • Sotnikova, Tatyana D., Jean-Martin Beaulieu, Larry S. Barak, William C. Wetsel, Marc G. Caron, and Raul R. Gainetdinov. “Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.” Plos Biol 3, no. 8 (August 2005): e271. https://doi.org/10.1371/journal.pbio.0030271.
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    • Kim, Kyeong-Man, Raul R. Gainetdinov, Stephane A. Laporte, Marc G. Caron, and Larry S. Barak. “G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.” J Biol Chem 280, no. 13 (April 1, 2005): 12774–80. https://doi.org/10.1074/jbc.M408901200.
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    • Chen, Wei, Xiu-Rong Ren, Christopher D. Nelson, Larry S. Barak, James K. Chen, Philip A. Beachy, Frederic de Sauvage, and Robert J. Lefkowitz. “Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.” Science 306, no. 5705 (December 24, 2004): 2257–60. https://doi.org/10.1126/science.1104135.
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    • Wilbanks, Alyson M., Gregory B. Fralish, Margaret L. Kirby, Larry S. Barak, Yin-Xiong Li, and Marc G. Caron. “Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.” Science 306, no. 5705 (December 24, 2004): 2264–67. https://doi.org/10.1126/science.1104193.
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    • Hildreth, Kerry L., Jiao-Hui Wu, Larry S. Barak, Sabrina T. Exum, Luke K. Kim, Karsten Peppel, and Neil J. Freedman. “Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.” J Biol Chem 279, no. 40 (October 1, 2004): 41775–82. https://doi.org/10.1074/jbc.M403274200.
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    • Bohn, L. M., L. A. Dykstra, R. J. Lefkowitz, M. G. Caron, and L. S. Barak. “Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.” Mol Pharmacol 66, no. 1 (July 2004): 106–12. https://doi.org/10.1124/mol.66.1.106.
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    • Johnson, Erik C., Laura M. Bohn, Larry S. Barak, Ryan T. Birse, Dick R. Nässel, Marc G. Caron, and Paul H. Taghert. “Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.” J Biol Chem 278, no. 52 (December 26, 2003): 52172–78. https://doi.org/10.1074/jbc.M306756200.
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    • Bektas, Meryem, Larry S. Barak, Puneet S. Jolly, Hong Liu, Kevin R. Lynch, Emanuela Lacana, Ki-Beom Suhr, Sheldon Milstien, and Sarah Spiegel. “The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.” Biochemistry 42, no. 42 (October 28, 2003): 12181–91. https://doi.org/10.1021/bi035051y.
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    • Chen, Wei, Derk ten Berge, Jeff Brown, Seungkirl Ahn, Liaoyuan A. Hu, William E. Miller, Marc G. Caron, Larry S. Barak, Roel Nusse, and Robert J. Lefkowitz. “Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.” Science 301, no. 5638 (September 5, 2003): 1391–94. https://doi.org/10.1126/science.1082808.
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    • Barak, Larry S., Robert H. Oakley, and Michael A. Shetzline. “G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors.” Assay Drug Dev Technol 1, no. 3 (June 2003): 409–24. https://doi.org/10.1089/154065803322163722.
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    • Barak, Larry S., Alyson M. Wilbanks, and Marc G. Caron. “Constitutive desensitization: a new paradigm for g protein-coupled receptor regulation.” Assay Drug Dev Technol 1, no. 2 (April 2003): 339–46. https://doi.org/10.1089/15406580360545152.
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    • Richardson, Ricardo M., Robin J. Marjoram, Larry S. Barak, and Ralph Snyderman. “Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation.” J Immunol 170, no. 6 (March 15, 2003): 2904–11. https://doi.org/10.4049/jimmunol.170.6.2904.
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    • Richardson, Mark D., Anastasia M. Balius, Keisuke Yamaguchi, Emily R. Freilich, Larry S. Barak, and Madan M. Kwatra. “Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.” J Neurochem 84, no. 4 (February 2003): 854–63. https://doi.org/10.1046/j.1471-4159.2003.01577.x.
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    • Wilbanks, Alyson M., Stéphane A. Laporte, Laura M. Bohn, Larry S. Barak, and Marc G. Caron. “Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.” Biochemistry 41, no. 40 (October 8, 2002): 11981–89. https://doi.org/10.1021/bi020275m.
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    • Naga Prasad, Sathyamangla V., Stéphane A. Laporte, Dean Chamberlain, Marc G. Caron, Larry Barak, and Howard A. Rockman. “Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.” J Cell Biol 158, no. 3 (August 5, 2002): 563–75. https://doi.org/10.1083/jcb.200202113.
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    • Kim, You-Me, Larry S. Barak, Marc G. Caron, and Jeffrey L. Benovic. “Regulation of arrestin-3 phosphorylation by casein kinase II.” J Biol Chem 277, no. 19 (May 10, 2002): 16837–46. https://doi.org/10.1074/jbc.M201379200.
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    • Shetzline, M. A., R. H. Oakley, M. G. Caron, and L. S. Barak. “Quantitative evaluation of CCK-B receptor regulation using an arrestin/green fluorescent protein biosensor: A novel technology for the determination of serum gastrin bioactivity.” Gastroenterology 122, no. 4 (April 1, 2002): A523–A523.
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    • Prasad, S. V. N., L. S. Barak, K. V. V. Woo, and H. A. Rockman. “Identification of the amino acid domain involved in the beta ARK/PI3K interaction and its role in beta AR sequestration.” Circulation 104, no. 17 (October 23, 2001): 144–144.
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    • Kim, K. M., K. J. Valenzano, S. R. Robinson, W. D. Yao, L. S. Barak, and M. G. Caron. “Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.” J Biol Chem 276, no. 40 (October 5, 2001): 37409–14. https://doi.org/10.1074/jbc.M106728200.
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    • Naga Prasad, S. V., L. S. Barak, A. Rapacciuolo, M. G. Caron, and H. A. Rockman. “Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.” J Biol Chem 276, no. 22 (June 1, 2001): 18953–59. https://doi.org/10.1074/jbc.M102376200.
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    • Oakley, R. H., S. A. Laporte, J. A. Holt, L. S. Barak, and M. G. Caron. “Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.” J Biol Chem 276, no. 22 (June 1, 2001): 19452–60. https://doi.org/10.1074/jbc.M101450200.
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    • Hobson, J. P., H. M. Rosenfeldt, L. S. Barak, A. Olivera, S. Poulton, M. G. Caron, S. Milstien, and S. Spiegel. “Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.” Science 291, no. 5509 (March 2, 2001): 1800–1803. https://doi.org/10.1126/science.1057559.
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    • Barak, L. S., R. H. Oakley, S. A. Laporte, and M. G. Caron. “Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.” Proc Natl Acad Sci U S A 98, no. 1 (January 2, 2001): 93–98. https://doi.org/10.1073/pnas.011303698.
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    • Prasad, S. V. N., L. S. Barak, A. Rapacciuolo, M. G. Caron, and H. A. Rockman. “beta-Adrenergic receptor kinase 1 mediated phosphoinositide-3-kinase translocation: A process linked to receptor internalization.” Circulation 102, no. 18 (October 31, 2000): 222–222.
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    • Laporte, S. A., R. H. Oakley, J. A. Holt, L. S. Barak, and M. G. Caron. “The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.” J Biol Chem 275, no. 30 (July 28, 2000): 23120–26. https://doi.org/10.1074/jbc.M002581200.
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    • Oakley, R. H., S. A. Laporte, J. A. Holt, M. G. Caron, and L. S. Barak. “Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.” J Biol Chem 275, no. 22 (June 2, 2000): 17201–10. https://doi.org/10.1074/jbc.M910348199.
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    • Carman, C. V., L. S. Barak, C. Chen, L. Y. Liu-Chen, J. J. Onorato, S. P. Kennedy, M. G. Caron, and J. L. Benovic. “Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.” J Biol Chem 275, no. 14 (April 7, 2000): 10443–52. https://doi.org/10.1074/jbc.275.14.10443.
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    • Jones, S. R., J. D. Joseph, L. S. Barak, M. G. Caron, and R. M. Wightman. “Dopamine neuronal transport kinetics and effects of amphetamine.” J Neurochem 73, no. 6 (December 1999): 2406–14. https://doi.org/10.1046/j.1471-4159.1999.0732406.x.
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    • Oakley, R. H., S. A. Laporte, J. A. Holt, L. S. Barak, and M. G. Caron. “Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization.” J Biol Chem 274, no. 45 (November 5, 1999): 32248–57. https://doi.org/10.1074/jbc.274.45.32248.
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    • Walker, J. K., R. T. Premont, L. S. Barak, M. G. Caron, and M. A. Shetzline. “Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.” J Biol Chem 274, no. 44 (October 29, 1999): 31515–23. https://doi.org/10.1074/jbc.274.44.31515.
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    • Zhang, J., L. S. Barak, P. H. Anborgh, S. A. Laporte, M. G. Caron, and S. S. Ferguson. “Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.” J Biol Chem 274, no. 16 (April 16, 1999): 10999–6. https://doi.org/10.1074/jbc.274.16.10999.
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    • Laporte, S. A., R. H. Oakley, J. Zhang, J. A. Holt, S. S. Ferguson, M. G. Caron, and L. S. Barak. “The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.” Proc Natl Acad Sci U S A 96, no. 7 (March 30, 1999): 3712–17. https://doi.org/10.1073/pnas.96.7.3712.
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    • Barak, L. S., K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra. “Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.” J Biol Chem 274, no. 11 (March 12, 1999): 7565–69. https://doi.org/10.1074/jbc.274.11.7565.
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    • Mhaouty-Kodja, S., L. S. Barak, A. Scheer, L. Abuin, D. Diviani, M. G. Caron, and S. Cotecchia. “Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.” Mol Pharmacol 55, no. 2 (February 1999): 339–47. https://doi.org/10.1124/mol.55.2.339.
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    • Barak, L. S., J. Zhang, S. S. Ferguson, S. A. Laporte, and M. G. Caron. “Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates.” Methods Enzymol 302 (1999): 153–71. https://doi.org/10.1016/s0076-6879(99)02016-9.
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    • Zhang, J., S. S. Ferguson, P. Y. Law, L. S. Barak, and M. G. Caron. “Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.” J Recept Signal Transduct Res 19, no. 1–4 (January 1999): 301–13. https://doi.org/10.3109/10799899909036653.
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    • Zhang, J., S. S. Ferguson, L. S. Barak, S. R. Bodduluri, S. A. Laporte, P. Y. Law, and M. G. Caron. “Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness.” Proc Natl Acad Sci U S A 95, no. 12 (June 9, 1998): 7157–62. https://doi.org/10.1073/pnas.95.12.7157.
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    • Pitcher, J. A., R. A. Hall, Y. Daaka, J. Zhang, S. S. Ferguson, S. Hester, S. Miller, M. G. Caron, R. J. Lefkowitz, and L. S. Barak. “The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.” J Biol Chem 273, no. 20 (May 15, 1998): 12316–24. https://doi.org/10.1074/jbc.273.20.12316.
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    • Feng, X., J. Zhang, L. S. Barak, T. Meyer, M. G. Caron, and Y. A. Hannun. “Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.” J Biol Chem 273, no. 17 (April 24, 1998): 10755–62. https://doi.org/10.1074/jbc.273.17.10755.
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    • Hall, R. A., R. T. Premont, C. W. Chow, J. T. Blitzer, J. A. Pitcher, A. Claing, R. H. Stoffel, et al. “The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.” Nature 392, no. 6676 (April 9, 1998): 626–30. https://doi.org/10.1038/33458.
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    • Ferguson, S. S., J. Zhang, L. S. Barak, and M. G. Caron. “Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.” Adv Pharmacol 42 (1998): 420–24. https://doi.org/10.1016/s1054-3589(08)60778-4.
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    • Ferguson, S. S., J. Zhang, L. S. Barak, and M. G. Caron. “Molecular mechanisms of G protein-coupled receptor desensitization and resensitization.” Life Sci 62, no. 17–18 (1998): 1561–65. https://doi.org/10.1016/s0024-3205(98)00107-6.
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    • Barak, L. S., J. Zhang, S. S. G. Ferguson, S. Miller, S. Hester, and M. G. Caron. “Association of beta adrenergic receptor kinase 1 with tubulin and mitochondrial membranes in living cells.” Molecular Biology of the Cell 8 (November 1, 1997): 265–265.
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    • Barak, L. S., S. S. Ferguson, J. Zhang, and M. G. Caron. “A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.” J Biol Chem 272, no. 44 (October 31, 1997): 27497–500. https://doi.org/10.1074/jbc.272.44.27497.
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    • Zhang, J., L. S. Barak, K. E. Winkler, M. G. Caron, and S. S. Ferguson. “A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.” J Biol Chem 272, no. 43 (October 24, 1997): 27005–14. https://doi.org/10.1074/jbc.272.43.27005.
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    • Ménard, L., S. S. Ferguson, J. Zhang, F. T. Lin, R. J. Lefkowitz, M. G. Caron, and L. S. Barak. “Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.” Mol Pharmacol 51, no. 5 (May 1997): 800–808.
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    • Barak, L. S., S. S. Ferguson, J. Zhang, C. Martenson, T. Meyer, and M. G. Caron. “Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.” Mol Pharmacol 51, no. 2 (February 1997): 177–84. https://doi.org/10.1124/mol.51.2.177.
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    • Ferguson, S. S. G., J. Zhang, L. S. Barak, and M. G. Caron. “Pleiotropic role for GRKs and β-arrestins in receptor regulation.” News in Physiological Sciences 12, no. 4 (January 1, 1997): 145–51. https://doi.org/10.1152/physiologyonline.1997.12.4.145.
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    • Zhang, J., S. S. Ferguson, L. S. Barak, M. J. Aber, B. Giros, R. J. Lefkowitz, and M. G. Caron. “Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.” Recept Channels 5, no. 3–4 (1997): 193–99.
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    • Barak, L. S., J. Zhang, S. S. G. Ferguson, and M. G. Caron. “Characterization of a green fluorescent protein conjugated Beta(2)-adrenergic receptor.” Molecular Biology of the Cell 7 (December 1, 1996): 2484–2484.
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    • Caron, M. G., J. Zhang, L. S. Barak, and S. S. G. Ferguson. “Molecular determinants of G protein-coupled receptor internalization: A mechanism of resensitization.” Molecular Biology of the Cell 7 (December 1, 1996): 973–973.
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    • Zhang, J., S. S. G. Ferguson, L. S. Barak, and M. G. Caron. “Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor endocytosis.” Molecular Biology of the Cell 7 (December 1, 1996): 485–485.
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    • Ferguson, S. S., J. Zhang, L. S. Barak, and M. G. Caron. “G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration.” Biochem Soc Trans 24, no. 4 (November 1996): 953–59. https://doi.org/10.1042/bst0240953.
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    • Ferguson, S. S., L. S. Barak, J. Zhang, and M. G. Caron. “G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins.” Can J Physiol Pharmacol 74, no. 10 (October 1996): 1095–1110. https://doi.org/10.1139/cjpp-74-10-1095.
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    • Zhang, J., S. S. Ferguson, L. S. Barak, L. Ménard, and M. G. Caron. “Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization.” J Biol Chem 271, no. 31 (August 2, 1996): 18302–5. https://doi.org/10.1074/jbc.271.31.18302.
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    • Ménard, L., S. S. Ferguson, L. S. Barak, L. Bertrand, R. T. Premont, A. M. Colapietro, R. J. Lefkowitz, and M. G. Caron. “Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.” Biochemistry 35, no. 13 (April 2, 1996): 4155–60. https://doi.org/10.1021/bi952961+.
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    • Ferguson, S. S., W. E. Downey, A. M. Colapietro, L. S. Barak, L. Ménard, and M. G. Caron. “Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.” Science 271, no. 5247 (January 19, 1996): 363–66. https://doi.org/10.1126/science.271.5247.363.
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    • Barak, L. S., L. Ménard, S. S. Ferguson, A. M. Colapietro, and M. G. Caron. “The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.” Biochemistry 34, no. 47 (November 28, 1995): 15407–14. https://doi.org/10.1021/bi00047a003.
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    • Ferguson, S. S., L. Ménard, L. S. Barak, W. J. Koch, A. M. Colapietro, and M. G. Caron. “Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.” J Biol Chem 270, no. 42 (October 20, 1995): 24782–89. https://doi.org/10.1074/jbc.270.42.24782.
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    • FERGUSON, S. S. G., L. MENARD, L. S. BARAK, A. M. COLAPIETRO, W. J. KOCH, and M. G. CARON. “A ROLE OF PHOSPHORYLATION IN AGONIST-PROMOTED SEQUESTRATION IMPLICATED BY THE RESCUE OF A SEQUESTRATION-DEFECTIVE BETA(2)-ADRENERGIC RECEPTOR MUTANT BY BETA-ARK1.” Faseb Journal 9, no. 6 (April 24, 1995): A1412–A1412.
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    • Barak, L. S., and M. G. Caron. “Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors.” J Recept Signal Transduct Res 15, no. 1–4 (January 1995): 677–90. https://doi.org/10.3109/10799899509045248.
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    • Barak, L. S., M. Tiberi, N. J. Freedman, M. M. Kwatra, R. J. Lefkowitz, and M. G. Caron. “A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.” J Biol Chem 269, no. 4 (January 28, 1994): 2790–95.
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    • CARON, M. G., M. TIBERI, and L. S. BARAK. “CATECHOLAMINE RECEPTORS - MOLECULAR CHARACTERIZATION AND PHYSIOLOGICAL IMPLICATIONS.” Neuropsychopharmacology 9, no. 2 (September 1, 1993): S35–36.
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    • BARAK, L. S., M. M. KWATRA, R. J. LEFKOWITZ, and M. G. CARON. “A HIGHLY CONSERVED MOTIF IN THE 7 TRANSMEMBRANE REGION OF THE BETA-2 ADRENERGIC-RECEPTOR DIRECTS RECEPTOR SEQUESTRATION.” Clinical Research 41, no. 2 (April 1, 1993): A258–A258.
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    • Gieron, M. A., L. S. Barak, and J. Estrada. “Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors.” J Neurooncol 6, no. 1 (1988): 29–30. https://doi.org/10.1007/BF00163537.
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    • Tank, D. W., W. J. Fredericks, L. S. Barak, and W. W. Webb. “Electric field-induced redistribution and postfield relaxation of low density lipoprotein receptors on cultured human fibroblasts.” J Cell Biol 101, no. 1 (July 1985): 148–57. https://doi.org/10.1083/jcb.101.1.148.
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    • Barak, L. S., and W. W. Webb. “Diffusion of low density lipoprotein-receptor complex on human fibroblasts.” J Cell Biol 95, no. 3 (December 1982): 846–52. https://doi.org/10.1083/jcb.95.3.846.
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    • Barak, L. S., and W. W. Webb. “Fluorescent low density lipoprotein for observation of dynamics of individual receptor complexes on cultured human fibroblasts.” J Cell Biol 90, no. 3 (September 1981): 595–604. https://doi.org/10.1083/jcb.90.3.595.
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    • Carley, W. W., L. S. Barak, and W. W. Webb. “F-actin aggregates in transformed cells.” J Cell Biol 90, no. 3 (September 1981): 797–802. https://doi.org/10.1083/jcb.90.3.797.
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    • Barak, L. S., E. A. Nothnagel, E. F. DeMarco, and W. W. Webb. “Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement?” Proc Natl Acad Sci U S A 78, no. 5 (May 1981): 3034–38. https://doi.org/10.1073/pnas.78.5.3034.
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    • Barak, L. S., R. R. Yocum, and W. W. Webb. “In vivo staining of cytoskeletal actin by autointernalization of nontoxic concentrations of nitrobenzoxadiazole-phallacidin.” J Cell Biol 89, no. 2 (May 1981): 368–72. https://doi.org/10.1083/jcb.89.2.368.
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    • Nothnagel, E. A., L. S. Barak, J. W. Sanger, and W. W. Webb. “Fluorescence studies on modes of cytochalasin B and phallotoxin action on cytoplasmic streaming in Chara.” J Cell Biol 88, no. 2 (February 1981): 364–72. https://doi.org/10.1083/jcb.88.2.364.
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    • BARAK, L. S., and W. W. WEBB. “MOLECULAR-MOTION OF INDIVIDUAL LDL MOLECULES ON CELL-MEMBRANES.” Biophysical Journal 33, no. 2 (January 1, 1981): A74–A74.
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    • Barak, L. S., and R. R. Yocum. “7-Nitrobenz-2-oxa-1,3-diazole (NBD)--phallacidin: synthesis of a fluorescent actin probe.” Anal Biochem 110, no. 1 (January 1, 1981): 31–38. https://doi.org/10.1016/0003-2697(81)90107-x.
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    • WEBB, W. W., L. S. BARAK, D. W. TANK, and E. S. WU. “DIFFUSIBILITY OF CELL-SURFACE PROTEINS-RELEASE OF CONSTRAINTS.” Journal of Cell Biology 91, no. 2 (January 1, 1981): A107–A107.
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    • Webb, W. W., L. S. Barak, D. W. Tank, and E. S. Wu. “Molecular mobility on the cell surface.” Biochem Soc Symp, no. 46 (1981): 191–205.
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    • Barak, L. S., R. R. Yocum, E. A. Nothnagel, and W. W. Webb. “Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin.” Proc Natl Acad Sci U S A 77, no. 2 (February 1980): 980–84. https://doi.org/10.1073/pnas.77.2.980.
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    • BARAK, L. S. “CORRECTION.” Proceedings of the National Academy of Sciences of the United States of America Biological Sciences 77, no. 6 (January 1, 1980): 3747–48.
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    • BARAK, L. S., and W. W. WEBB. “INVIVO LABELING OF CYTOSKELETAL ACTIN BY NBD-PHALLACIDIN.” Journal of Cell Biology 87, no. 2 (January 1, 1980): A214–A214.
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    • Schlessinger, J., L. S. Barak, G. G. Hammes, K. M. Yamada, I. Pastan, W. W. Webb, and E. L. Elson. “Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components.” Proc Natl Acad Sci U S A 74, no. 7 (July 1977): 2909–13. https://doi.org/10.1073/pnas.74.7.2909.
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    • Fahey, P. F., D. E. Koppel, L. S. Barak, D. E. Wolf, E. L. Elson, and W. W. Webb. “Lateral diffusion in planar lipid bilayers.” Science 195, no. 4275 (January 21, 1977): 305–6. https://doi.org/10.1126/science.831279.
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  • Conference Papers

    • Mook, Robert A., Minyong Chen, Jiuyi Lu, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Abstract 5681: Modulation of Wnt/β-catenin signaling by niclosamide and related derivatives.” In Cancer Chemistry. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-5681.
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    • Masri, B., L. S. Barak, Y. Bai, B. Knibiehler, M. G. Caron, and Y. Audigier. “Identification and pharmacological properties of an antagonist of apelin receptors.” In Regul Pept, 164:26, 2010. https://doi.org/10.1016/j.regpep.2010.07.057.
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    • Exum, S. T., K. Peppel, L. S. Barak, R. T. Premont, L. S. Zhang, and N. J. Freedman. “Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinases in smooth muscle cells and fibroblasts: Evidence for kinase specificity.” In Circulation, 110:255–255. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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    • Zhang, J., S. S. G. Ferguson, L. S. Barak, M. J. Aber, B. Giros, R. J. Lefkowitz, and M. G. Caron. “Mini-Review - Molecular mechanisms of G protein-coupled receptor signaling: Role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.” In Receptors & Channels, 5:193–99. HARWOOD ACAD PUBL GMBH, 1997.
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