Scholars@Duke
Edith Lacey Washington

Edith Lacey Washington

Associate Professor of Radiology
Radiology, Cardiothoracic Imaging
lacey.washington@duke.edu
Box 3808 Med Ctr, Durham, NC 27710
Dept of Radiology, Durham, NC 27710

Scholarly Works - Journal articles

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

Journal article J Allergy Clin Immunol · June 2018 BACKGROUND: Eosinophilic airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting potential shared mechanisms with eosinophilic asthma. However, there is no ... Full text Link to item Cite

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.

Journal article Chest · January 2018 BACKGROUND: Emphysema has considerable variability in its regional distribution. Craniocaudal emphysema distribution is an important predictor of the response to lung volume reduction. However, there is little consensus regarding how to define upper lobe-p ... Full text Link to item Cite

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Journal article PLoS Genet · August 2016 Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental variations contribute to phenotypic di ... Full text Link to item Cite

Clinical and Radiologic Disease in Smokers With Normal Spirometry.

Journal article JAMA Intern Med · September 2015 IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE: To identify clinical and r ... Full text Link to item Cite

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.

Journal article Am J Respir Cell Mol Biol · November 2014 Hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among patien ... Full text Link to item Cite

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.

Journal article Ann Am Thorac Soc · November 2014 RATIONALE: The demographic, physiological, and computed tomography (CT) features associated with pneumothorax in smokers with and without chronic obstructive pulmonary disease (COPD) are not clearly defined. OBJECTIVES: We evaluated the hypothesis that pne ... Full text Link to item Cite

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.

Journal article BMC Pulm Med · October 24, 2014 BACKGROUND: Chronic obstructive pulmonary disease (COPD) has been classically divided into blue bloaters and pink puffers. The utility of these clinical subtypes is unclear. However, the broader distinction between airway-predominant and emphysema-predomin ... Full text Link to item Cite

Prediction of acute respiratory disease in current and former smokers with and without COPD.

Journal article Chest · October 2014 BACKGROUND: The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown. METHODS: Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epid ... Full text Link to item Cite

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.

Journal article Respir Res · September 21, 2014 BACKGROUND: Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and to assess for genetic differences ... Full text Link to item Cite

Imaging of complications of thoracic and cardiovascular surgery.

Journal article Radiol Clin North Am · September 2014 Iatrogenic complications of thoracic and cardiovascular surgery are relatively uncommon, but contribute to potentially significant patient morbidity and mortality. The incidence of iatrogenic disease reflects the complexity of surgical procedures, includin ... Full text Link to item Cite

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.

Journal article Respir Res · August 6, 2014 BACKGROUND: Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies invest ... Full text Link to item Cite

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

Journal article Respiratory Research · August 6, 2014 Background: Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mor ... Full text Cite

Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study.

Journal article Respir Res · April 27, 2014 BACKGROUND: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more ... Full text Link to item Cite

Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study

Journal article Respiratory Research · April 27, 2014 Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more ... Full text Cite

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Journal article Lancet Respir Med · March 2014 BACKGROUND: The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified by genome-wide association studies in larger cohorts or specific subg ... Full text Link to item Cite

Preliminary evaluation of biplane correlation (BCI) stereographic imaging for lung nodule detection.

Journal article J Digit Imaging · February 2013 A biplane correlation (BCI) imaging system obtains images that can be viewed in stereo, thereby minimizing overlapping structures. This study investigated whether using stereoscopic visualization provides superior lung nodule detection compared to standard ... Full text Link to item Cite

The effects of ambient lighting in chest radiology reading rooms.

Journal article J Digit Imaging · August 2012 Under typical dark chest radiography reading room conditions, a radiologist's pupils contract and dilate as their visual focus intermittently shifts between the high luminance monitor and the darker background wall, resulting in increased visual fatigue an ... Full text Link to item Cite

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease.

Journal article Thorax · May 2012 BACKGROUND: The value of quantitative CT (QCT) to identify chronic obstructive pulmonary disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Q ... Full text Link to item Cite

Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.

Journal article Chest · April 2012 BACKGROUND: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV(1). We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) ... Full text Link to item Cite

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation.

Journal article COPD · April 2012 UNLABELLED: The purposes of this study were: to describe chest CT findings in normal non-smoking controls and cigarette smokers with and without COPD; to compare the prevalence of CT abnormalities with severity of COPD; and to evaluate concordance between ... Full text Link to item Cite

Genome-wide association study of smoking behaviours in patients with COPD.

Journal article Thorax · October 2011 Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the numb ... Full text Link to item Cite

The clinical features of the overlap between COPD and asthma.

Journal article Respir Res · September 27, 2011 BACKGROUND: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. METHODS: We performed a cross-sec ... Full text Link to item Cite

Bronchial artery arising from the left vertebral artery: case report and review of the literature.

Journal article J Clin Imaging Sci · 2011 Knowledge of bronchial artery anatomy, including the possible locations of anomalous origin, is essential for complete catheter directed embolization for massive hemoptysis. Undetected anomalous bronchial arteries can be a source of failed bronchial artery ... Full text Link to item Cite

The role of biomarkers in thoracic imaging

Journal article Imaging in Medicine · October 1, 2010 Thoracic imaging plays an essential role in understanding and diagnosing chest disease. It has traditionally relied on conventional anatomic and morphologic imaging, but as technology evolves, novel diagnostic strategies have the potential to improve accur ... Full text Cite

Nonsurgical extracardiac vascular shunts in the thorax: clinical and imaging characteristics.

Journal article Radiographics · September 2010 Extracardiac nonsurgical vascular shunts in the thorax are a group of well-recognized heterogeneous conditions, frequently symptomatic, in which there is diversion of blood flow from one vessel to another or from a vessel to a cardiac chamber. The authors ... Full text Link to item Cite

ACR Appropriateness Criteria on acute respiratory illness.

Journal article J Am Coll Radiol · October 2009 Featured Publication In a patient with acute respiratory illness (cough, sputum production, chest pain, and/or dyspnea), the need for chest imaging depends on the severity of illness, age of the patient, clinical history, physical and laboratory findings, and other risk factor ... Full text Link to item Cite

Design and Development of a New Multi-Projection X-Ray System for Chest Imaging.

Journal article IEEE Trans Nucl Sci · February 2009 Overlapping anatomical structures may confound the detection of abnormal pathology, including lung nodules, in conventional single-projection chest radiography. To minimize this fundamental limiting factor, a dedicated digital multi-projection system for c ... Full text Link to item Cite

Imaging appearances of the sternum and sternoclavicular joints.

Journal article Radiographics · 2009 Featured Publication The sternum and sternoclavicular joints--critical structures of the anterior chest wall--may be affected by various anatomic anomalies and pathologic processes, some of which require treatment. Pectus excavatum and pectus carinatum are common congenital an ... Full text Link to item Cite

Imaging of bacterial pulmonary infection in the immunocompetent patient.

Journal article Semin Roentgenol · April 2007 Featured Publication Pulmonary infection is a common reason for imaging of the lung and a common incidental finding in immunocompetent patients. Findings on chest radiography are nonspecific in defining acute infection; however, the radiologist should be aware of classically d ... Full text Link to item Cite

Imaging manifestations of blastomycosis: a pulmonary infection with potential dissemination.

Journal article Radiographics · 2007 Featured Publication Pulmonary blastomycosis is an uncommon pathologic condition that is endemic to Canada and the upper Midwest of the United States. Blastomycosis has a variety of radiologic manifestations, including airspace consolidation, focal masses, intermediate-sized n ... Full text Link to item Cite

Incidence and management of occult hemothoraces.

Journal article Am J Surg · December 2006 BACKGROUND: Little is known about the incidence of and associated management outcomes of occult hemothorax in blunt trauma patients. The increased use of computed thoracic tomography for the evaluation of the multiply injured blunt trauma patient has led t ... Full text Link to item Cite

Inherent variability of CT lung nodule measurements in vivo using semiautomated volumetric measurements.

Journal article AJR Am J Roentgenol · April 2006 Featured Publication OBJECTIVE: The objective of our study was to evaluate repeatability and reproducibility of lung nodule volume measurements using volumetric nodule-sizing software. MATERIALS AND METHODS: Fifty nodules, less than 20 mm in diameter, in 29 patients were scann ... Full text Link to item Cite

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Journal article American Journal of Roentgenology · December 1, 2005 Cite

CT of deep venous thrombosis and pulmonary embolus: does iso-osmolar contrast agent improve vascular opacification?

Journal article Radiology · March 2005 Featured Publication PURPOSE: To prospectively compare the vascular attenuation achieved with the iso-osmolar dimeric contrast agent iodixanol with that achieved with the nonionic monomeric contrast agent iohexol for computed tomographic (CT) venography after CT pulmonary angi ... Full text Link to item Cite

Clinicians' response to radiologists' reports of isolated subsegmental pulmonary embolism or inconclusive interpretation of pulmonary embolism using MDCT.

Journal article AJR Am J Roentgenol · February 2005 Featured Publication OBJECTIVE: The purpose of our study was to investigate clinician response and patient outcome associated with the radiologist's report of isolated subsegmental pulmonary emboli (ISSPE) or indeterminate or inconclusive results on MDCT for venous thromboembo ... Full text Link to item Cite

Incidence of asymptomatic pulmonary embolism in moderately to severely injured trauma patients.

Journal article J Trauma · April 2004 BACKGROUND: Chest computed tomographic (CT) scanning is used frequently to evaluate symptomatic patients for pulmonary embolus (PE). The incidence of PE diagnosed by helical CT scanning in asymptomatic patients is unknown. METHODS: Asymptomatic trauma pati ... Full text Link to item Cite

Venous thromboembolic disease: where does multidetector computed tomography fit?

Journal article Cardiol Clin · November 2003 Introduction of helical CT started a new era in the diagnosis of PE. It is noninvasive and readily available. Developments in helical CT technology (particularly introduction of multidetector scanners) improved image quality by decreasing the scanning time ... Full text Link to item Cite

CT for thromboembolic disease.

Journal article Curr Probl Diagn Radiol · 2003 Pulmonary embolism (PE) and deep venous thrombosis (DVT) constitute the two clinical manifestations of venous thromboembolic disease (VTE). The recent innovation of computed tomography venography (CTV) in conjunction with CT pulmonary arteriography (CTPA) ... Full text Link to item Cite

CT for thromboembolic disease.

Journal article Radiol Clin North Am · July 2002 CTPA has dramatically changed the diagnostic approach to PE in the last decade. The addition of CTV has created a single diagnostic test that can evaluate for both important components of venous thromboembolic disease. Newer, multislice scanners will provi ... Full text Link to item Cite

Indirect CT venography following CT pulmonary angiography: spectrum of CT findings.

Journal article J Thorac Imaging · January 2002 Pulmonary embolism (PE) and deep venous thrombosis (DVT) represent two manifestations of the same syndrome, venous thromboembolism. Contrast-enhanced computed tomography (CT) angiography is a practical, efficient alternative to conventional imaging for PE. ... Full text Link to item Cite

Mycobacterial infection in immunocompromised patients.

Journal article J Thorac Imaging · October 1998 Mycobacterial infection, including both tuberculosis and nontuberculous mycobacterial infection, is an important cause of morbidity and mortality in immunocompromised patients, particularly those who are infected with the human immunodeficiency virus. When ... Full text Link to item Cite