Nwora Lance Okeke | Scholars@Duke

Nwora Lance Okeke
Assistant Professor of Medicine

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2021
Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2020

Contact Information

Dept of Medicine, Box 31255, Durham, NC 27710
lance.okeke@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- Infectious Diseases Fellowship, Medicine, Duke University School of Medicine 2011 - 2015
- M.P.H., University of North Carolina - Chapel Hill 2015
- Internal Medicine Resdency, Medicine, Duke University School of Medicine 2007 - 2010
- M.D., Stanford University, School of Medicine 2007
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2017 - 2020
- Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2015 - 2017
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2010 - 2011
Recognition
In the News
- OCT 30, 2020 School of Medicine Magnify
  
  Clinical Researchers Seek Ways to Lessen the Severity of COVID-19
- APR 25, 2016
  
  Tracking the Spread of HIV's Resistance in NC
- MAR 23, 2016
  
  Collaborative Grants Encourage UNC and Duke Researchers to Leave Rivalry on the Court
Research
Selected Grants
- Mechanisms of HIV persistence in the kidney (R01) awarded by National Institutes of Health 2022 - 2027
- Leveraging Local Health System Electronic Health Record Data to Enhance PrEP Access in Southeastern Louisiana: A Community-Informed Approach (R01) awarded by National Institutes of Health 2022 - 2027
- The development and validation of a scale to measure Treatment Regimen Fatigue among older adults living with HIV awarded by National Institutes of Health 2022 - 2026
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- EJAF HIV CME Training Development awarded by Elton John AIDS Foundation 2022 - 2025
- A nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention (EXTRA-CVD) awarded by University of Washington 2021 - 2023
- Randomized Trial to Prevent Vascular Events in HIV- REPRIEVE (A5332) awarded by Massachusetts General Hospital 2015 - 2023
- Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID (ACTIV-2/A5401)) - SAB awarded by PPD Investigator Services, LLC 2021 - 2023
- Pathways to cardiovascular disease prevention and impact of specialty referral in under-represented racial/ethnic minorities with HIV awarded by National Institutes of Health 2018 - 2023
- Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID (ACTIV-2/A5401)) - Astrazeneca awarded by PPD Investigator Services, LLC 2021 - 2023
- Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID (ACTIV-2/A5401)) - Sagent Camostat awarded by PPD Investigator Services, LLC 2021 - 2023
- Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID (ACTIV-2/A5401)) - Brii awarded by PPD Investigator Services, LLC 2021 - 2023
- Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID (ACTIV-2/A5401)) - Synairgen awarded by PPD Investigator Services, LLC 2022 - 2023
- A Multidisciplinary Approach to Primary Cardiovascular Disease Prevention in HIV-infected (K23) awarded by National Institutes of Health 2018 - 2022
- Evidence2Practice: Leveraging implementation science to recruit HBCU/MSI students into careers in HIV research (CFAR CDEIPI Supplement) awarded by The George Washington University 2021 - 2022
- Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2022
- Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID (ACTIV-2/A5401)) awarded by PPD Investigator Services, LLC 2020 - 2022
- Adapt Out COVID (ACTIV-2/A5401) - BMS awarded by PPD Investigator Services, LLC 2021 - 2022
- A nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention (EXTRA-CVD) awarded by Case Western Reserve University 2018 - 2022
- Bringing PrEP to Campus: Examining Strategies for PrEP Delivery to Historically Black College and Universities (HBCU) awarded by National Institutes of Health 2005 - 2020
- 6510 HIV-HCV SWITCH - (337-1834) awarded by Duke Clinical Research Institute 2016 - 2019
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
External Relationships
- Gilead Sciences, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mitchell, John T., Charles M. Burns, Breyah Atkinson, Mackenzie Cottrell, Justin K. Frye, Mehri S. McKellar, Angela D. M. Kashuba, F Joseph McClernon, and Nwora Lance Okeke. “Feasibility, Acceptability, and Preliminary Efficacy of a Gamified Mobile Health Contingency Management Intervention for PrEP Adherence Among Black MSM.” Aids Behav 26, no. 10 (October 2022): 3311–24. https://doi.org/10.1007/s10461-022-03675-9.
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  - Vasudevan, Lavanya, Rebecca Bruening, Anna Hung, Sandra Woolson, Adrian Brown, Susan N. Hastings, Tammy Linton, et al. “COVID-19 vaccination intention and activation among health care system employees: A mixed methods study.” Vaccine 40, no. 35 (August 19, 2022): 5141–52. https://doi.org/10.1016/j.vaccine.2022.07.010.
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  - Muiruri, Charles, Amy Corneli, Linda Cooper, Carrie Dombeck, Shamea Gray, Chris T. Longenecker, Eric G. Meissner, et al. “Perspectives of HIV specialists and cardiologists on the specialty referral process for people living with HIV: a qualitative descriptive study.” Bmc Health Serv Res 22, no. 1 (May 9, 2022): 623. https://doi.org/10.1186/s12913-022-08015-0.
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  - Mitchell, John T., Charles M. Burns, Breyah Atkinson, Mackenzie Cottrell, Justin K. Frye, Mehri S. McKellar, Angela D. M. Kashuba, F Joseph McClernon, and Nwora Lance Okeke. “Correction to: Feasibility, Acceptability, and Preliminary Efficacy of a Gamified Mobile Health Contingency Management Intervention for PrEP Adherence Among Black MSM.” Aids Behav, May 4, 2022. https://doi.org/10.1007/s10461-022-03698-2.
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  - Burns, Charles M., Monica Borges, Justin Frye, Kathryn Keicher, Scotty Elliott, Sheila Schwartz, Kenneth Shipp, Nwora Lance Okeke, and Mehri S. McKellar. “Understanding Retention in Pre-Exposure Prophylaxis Care in the South: Insights from an Academic HIV Prevention Clinic.” Aids Res Hum Retroviruses 38, no. 4 (April 2022): 306–12. https://doi.org/10.1089/AID.2021.0177.
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  - Narayanasamy, Shanti, Ahmad Mourad, Nicholas A. Turner, Thuy Le, Robert J. Rolfe, Nwora Lance Okeke, Sean M. O’Brien, et al. “COVID-19 Trials: Who Participates and Who Benefits?” South Med J 115, no. 4 (April 2022): 256–61. https://doi.org/10.14423/SMJ.0000000000001374.
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  - Bloomfield, Gerald S., Fawaz Alenezi, Karen Chiswell, Allison Dunning, Nwora Lance Okeke, and Eric J. Velazquez. “Progression of cardiac structure and function in people with human immunodeficiency virus.” Echocardiography 39, no. 2 (February 2022): 268–77. https://doi.org/10.1111/echo.15302.
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  - Manavalan, Preeti, Deng Buok Madut, Julian Thornton Hertz, Nathan Maclyn Thielman, Nwora Lance Okeke, Blandina Theophil Mmbaga, and Melissa Harper Watt. “Hypertension among adults enrolled in HIV care in northern Tanzania: comorbidities, cardiovascular risk, and knowledge, attitudes and practices.” Pan Afr Med J 41 (2022): 285. https://doi.org/10.11604/pamj.2022.41.285.26952.
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  - Prattipati, Sainikitha, Francis M. Sakita, Tumsifu G. Tarimo, Godfrey L. Kweka, Jerome J. Mlangi, Amedeus V. Maro, Lauren A. Coaxum, et al. “Prevalence and Correlates of Ischemic ECG Findings among Adults With and Without HIV in Tanzania.” Glob Heart 17, no. 1 (2022): 38. https://doi.org/10.5334/gh.1127.
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  - Kileel, Emma M., Janet Lo, Carlos Malvestutto, Kathleen V. Fitch, Markella V. Zanni, Carl J. Fichtenbaum, Edgar T. Overton, et al. “Assessment of Obesity and Cardiometabolic Status by Integrase Inhibitor Use in REPRIEVE: A Propensity-Weighted Analysis of a Multinational Primary Cardiovascular Prevention Cohort of People With Human Immunodeficiency Virus.” Open Forum Infect Dis 8, no. 12 (December 2021): ofab537. https://doi.org/10.1093/ofid/ofab537.
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  - Okeke, Nwora Lance, Tony McLaurin, Ruth Gilliam-Phillips, David H. Wagner, Valerie J. Barnwell, Yolanda M. Johnson, Osaffo James, et al. “Awareness and acceptability of HIV pre-exposure prophylaxis (PrEP) among students at two historically Black universities (HBCU): a cross-sectional survey.” Bmc Public Health 21, no. 1 (May 19, 2021): 943. https://doi.org/10.1186/s12889-021-10996-2.
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  - Mourad, Ahmad, Nicholas A. Turner, Arthur W. Baker, Nwora Lance Okeke, Shanti Narayanasamy, Robert Rolfe, John J. Engemann, Gary M. Cox, and Jason E. Stout. “Social Disadvantage, Politics, and Severe Acute Respiratory Syndrome Coronavirus 2 Trends: A County-level Analysis of United States Data.” Clin Infect Dis 72, no. 10 (May 18, 2021): e604–7. https://doi.org/10.1093/cid/ciaa1374.
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  - Axfors, Cathrine, Andreas M. Schmitt, Perrine Janiaud, Janneke Van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, et al. “Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.” Nat Commun 12, no. 1 (May 14, 2021): 3001. https://doi.org/10.1038/s41467-021-23559-1.
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  - Axfors, Cathrine, Andreas M. Schmitt, Perrine Janiaud, Janneke Van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, et al. “Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.” Nat Commun 12, no. 1 (April 15, 2021): 2349. https://doi.org/10.1038/s41467-021-22446-z.
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  - Clement, Meredith Edwards, Mira Nicchitta, Ying Sun, Alicia Ellis, Hrishikesh Chakraborty, Kara McGee, Cedar Eagle, et al. “Preexposure Prophylaxis Outcomes in an Urban Community in North Carolina: Discontinuation of Care and Sexually Transmitted Infections.” Sex Transm Dis 48, no. 3 (March 1, 2021): 183–88. https://doi.org/10.1097/OLQ.0000000000001288.
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  - Seidelman, Jessica, Molly Fleece, Allison Bloom, Emily Lydon, Wesley Yang, Christopher Arnold, David J. Weber, and Nwora Lance Okeke. “Endogenous Candida endophthalmitis: Who is really at risk?” J Infect 82, no. 2 (February 2021): 276–81. https://doi.org/10.1016/j.jinf.2020.12.032.
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  - Mkumba, Laura, Charles Muiruri, Keva Garg, Melissa H. Watt, and Nwora Lance Okeke. “Perspectives of Chronic Disease Management Among Persons with HIV: A Qualitative Study.” Patient Prefer Adherence 15 (2021): 49–55. https://doi.org/10.2147/PPA.S287325.
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  - Webel, Allison R., Julie Schexnayder, C Robin Rentrope, Hayden B. Bosworth, Corrilynn O. Hileman, Nwora Lance Okeke, Rajesh Vedanthan, and Chris T. Longenecker. “The influence of healthcare financing on cardiovascular disease prevention in people living with HIV.” Bmc Public Health 20, no. 1 (November 23, 2020): 1768. https://doi.org/10.1186/s12889-020-09896-8.
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  - Okeke, Nwora Lance, Katherine R. Schafer, Eric G. Meissner, Jan Ostermann, Ansal D. Shah, Brian Ostasiewski, Evan Phelps, et al. “Cardiovascular Disease Risk Management in Persons With HIV: Does Clinician Specialty Matter?” Open Forum Infect Dis 7, no. 9 (September 2020): ofaa361. https://doi.org/10.1093/ofid/ofaa361.
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  - Manavalan, Preeti, Deng B. Madut, Julian T. Hertz, Nathan M. Thielman, Nwora Lance Okeke, Blandina T. Mmbaga, and Melissa H. Watt. “Hypertension burden and challenges across the hypertension treatment cascade among adults enrolled in HIV care in northern Tanzania.” J Clin Hypertens (Greenwich) 22, no. 8 (August 2020): 1518–22. https://doi.org/10.1111/jch.13929.
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  - Perfect, Chelsea, Lindsay Wilson, David Wohl, Nwora Lance Okeke, Aroonsiri Sangarlangkarn, and Sue Tolleson-Rinehart. “Improving Care for Older Adults with HIV: Identifying Provider Preferences and Priorities.” J Am Geriatr Soc 68, no. 4 (April 2020): 891–92. https://doi.org/10.1111/jgs.16296.
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  - Aifah, Angela, Nwora Lance Okeke, Cynthia R. Rentrope, Julie Schexnayder, Gerald S. Bloomfield, Hayden Bosworth, Kiran Grover, et al. “Use of a human-centered design approach to adapt a nurse-led cardiovascular disease prevention intervention in HIV clinics.” Prog Cardiovasc Dis 63, no. 2 (March 2020): 92–100. https://doi.org/10.1016/j.pcad.2020.02.013.
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  - Muiruri, Charles, Chris T. Longenecker, Eric G. Meissner, Nwora Lance Okeke, April C. Pettit, Kevin Thomas, Eric Velazquez, and Gerald S. Bloomfield. “Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature.” Prog Cardiovasc Dis 63, no. 2 (March 2020): 142–48. https://doi.org/10.1016/j.pcad.2020.02.006.
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  - Manavalan, Preeti, Linda Minja, Lisa Wanda, Julian T. Hertz, Nathan M. Thielman, Nwora Lance Okeke, Blandina T. Mmbaga, and Melissa H. Watt. “"It's because I think too much": Perspectives and experiences of adults with hypertension engaged in HIV care in northern Tanzania.” Plos One 15, no. 12 (2020): e0243059. https://doi.org/10.1371/journal.pone.0243059.
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  - Muiruri, Charles, Isabelle P. Sico, Julie Schexnayder, Allison R. Webel, Nwora Lance Okeke, Christopher T. Longenecker, Juan Marcos Gonzalez, Kelley A. Jones, Sarah E. Gonzales, and Hayden B. Bosworth. “Why Do People Living with HIV Adhere to Antiretroviral Therapy and Not Comorbid Cardiovascular Disease Medications? A Qualitative Inquiry.” Patient Prefer Adherence 14 (2020): 985–94. https://doi.org/10.2147/PPA.S254882.
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  - Okeke, Nwora Lance, Allison R. Webel, Hayden B. Bosworth, Angela Aifah, Gerald S. Bloomfield, Emily W. Choi, Sarah Gonzales, et al. “Rationale and design of a nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention trial (EXTRA-CVD).” Am Heart J 216 (October 2019): 91–101. https://doi.org/10.1016/j.ahj.2019.07.005.
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  - Alenezi, Fawaz, Gerald S. Bloomfield, Nwora Lance Okeke, Poonam Velagapudi, Loai Abudaqa, Nkechinyere Ijioma, Allison Dunning, et al. “Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus.” Am J Cardiol 124, no. 6 (September 15, 2019): 966–71. https://doi.org/10.1016/j.amjcard.2019.06.013.
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  - McGee, Kara S., Nwora Lance Okeke, Christopher B. Hurt, and Mehri S. McKellar. “Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient.” Open Forum Infect Dis 5, no. 11 (November 2018): ofy294. https://doi.org/10.1093/ofid/ofy294.
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  - Levintow, S. N., N. L. Okeke, S. Hué, L. Mkumba, A. Virkud, S. Napravnik, J. Sebastian, W. C. Miller, J. J. Eron, and A. M. Dennis. “Prevalence and transmission dynamics of HIV-1 transmitted drug resistance in a southeastern cohort.” Open Forum Infectious Diseases 5, no. 8 (August 1, 2018). https://doi.org/10.1093/ofid/ofy178.
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  - Okeke, Nwora Lance, Fawaz Alenezi, Gerald S. Bloomfield, Allison Dunning, Meredith E. Clement, Svati H. Shah, Susanna Naggie, and Eric J. Velazquez. “Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.” J Card Fail 24, no. 8 (August 2018): 496–503. https://doi.org/10.1016/j.cardfail.2018.06.003.
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  - Clement, Meredith E., Jessica Seidelman, Jiewei Wu, Kareem Alexis, Kara McGee, N Lance Okeke, Gregory Samsa, and Mehri McKellar. “An educational initiative in response to identified PrEP prescribing needs among PCPs in the Southern U.S.” Aids Care 30, no. 5 (May 2018): 650–55. https://doi.org/10.1080/09540121.2017.1384534.
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  - Okeke, Nwora Lance, Damian M. Craig, Michael J. Muehlbauer, Olga Ilkayeva, Meredith E. Clement, Susanna Naggie, and Svati H. Shah. “Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.” Metabolomics 14, no. 3 (March 2018). https://doi.org/10.1007/s11306-018-1318-z.
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  - Clement, Meredith E., Li Lin, Ann Marie Navar, Nwora Lance Okeke, Susanna Naggie, and Pamela S. Douglas. “Lower likelihood of cardiac procedures after acute coronary syndrome in patients with human immunodeficiency virus/acquired immunodeficiency syndrome.” Medicine (Baltimore) 97, no. 6 (February 2018): e9849. https://doi.org/10.1097/MD.0000000000009849.
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  - Clement, Meredith E., Nwora L. Okeke, Terry Munn, Miguel Hunter, Kareem Alexis, Amy Corneli, Arlene C. Seña, Kara McGee, and Mehri S. McKellar. “Partnerships Between a University-Affiliated Clinic and Community-Based Organizations to Reach Black Men Who Have Sex With Men for PrEP Care.” J Acquir Immune Defic Syndr 77, no. 2 (February 1, 2018): e25–27. https://doi.org/10.1097/QAI.0000000000001577.
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  - Clement, Meredith E., Lawrence P. Park, Ann Marie Navar, Nwora Lance Okeke, Michael J. Pencina, Pamela S. Douglas, and Susanna Naggie. “Statin Utilization and Recommendations Among HIV- and HCV-infected Veterans: A Cohort Study.” Clin Infect Dis 63, no. 3 (August 1, 2016): 407–13. https://doi.org/10.1093/cid/ciw289.
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  - Okeke, Nwora Lance, Thibaut Davy, Joseph J. Eron, and Sonia Napravnik. “Hypertension Among HIV-infected Patients in Clinical Care, 1996-2013.” Clin Infect Dis 63, no. 2 (July 15, 2016): 242–48. https://doi.org/10.1093/cid/ciw223.
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  - Okeke, Nwora Lance, Charles B. Hicks, Mehri S. McKellar, Vance G. Fowler, and Jerome J. Federspiel. “History of AIDS in HIV-Infected Patients Is Associated With Higher In-Hospital Mortality Following Admission for Acute Myocardial Infarction and Stroke.” J Infect Dis 213, no. 12 (June 15, 2016): 1955–61. https://doi.org/10.1093/infdis/jiw082.
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  - Okeke, Nwora Lance, Tammy Chin, Meredith Clement, Shein-Chung Chow, and Charles B. Hicks. “Coronary artery disease risk reduction in HIV-infected persons: a comparative analysis.” Aids Care 28, no. 4 (2016): 475–82. https://doi.org/10.1080/09540121.2015.1099602.
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  - Clement, Meredith E., N Lance Okeke, and Charles B. Hicks. “Fever and Rash in a Patient With Hepatitis.” Jama 314, no. 4 (July 28, 2015): 400–401. https://doi.org/10.1001/jama.2015.3401.
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  - Clement, Meredith E., N Lance Okeke, and Charles B. Hicks. “Treatment of late-stage syphilis--reply.” Jama 313, no. 9 (March 3, 2015): 969–70. https://doi.org/10.1001/jama.2015.0675.
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  - Okeke, N Lance, Jan Ostermann, and Nathan M. Thielman. “Enhancing linkage and retention in HIV care: a review of interventions for highly resourced and resource-poor settings.” Curr Hiv/Aids Rep 11, no. 4 (December 2014): 376–92. https://doi.org/10.1007/s11904-014-0233-9.
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  - Clement, Meredith E., N Lance Okeke, and Charles B. Hicks. “Treatment of syphilis: a systematic review.” Jama 312, no. 18 (November 12, 2014): 1905–17. https://doi.org/10.1001/jama.2014.13259.
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  - Okeke, N. L., and C. Hicks. “Role of raltegravir in the management of HIV-1 infection.” Hiv/Aids Research and Palliative Care 3 (July 15, 2011): 81–92. https://doi.org/10.2147/HIV.S13985.
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  - Zhao, Xiaoyan, Nwora Lance Okeke, Orr Sharpe, Franak M. Batliwalla, Annette T. Lee, Peggy P. Ho, Beren H. Tomooka, Peter K. Gregersen, and William H. Robinson. “Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis.” Arthritis Res Ther 10, no. 4 (2008): R94. https://doi.org/10.1186/ar2478.
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  - Graham, Kareem L., Donna L. Thibault, Jonathan B. Steinman, Lance Okeke, Peter N. Kao, and Paul J. Utz. “Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.” Arthritis Rheum 52, no. 6 (June 2005): 1684–93. https://doi.org/10.1002/art.21092.
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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles