Laura Pope Hale | Scholars@Duke

Laura Pope Hale
Professor of Pathology

The Hale laboratory employs techniques of cellular and molecular biology to study mechanisms responsible for the generation of both normal immune responses and immune-mediated diseases. Research in the laboratory is mainly focused on inflammatory bowel disease (IBD), an immune-mediated disorder that is hypothesized to result from the abnormal immune response of a genetically susceptible host to the antigens derived from enteric bacteria. Development of optimal treatments for disease requires a detailed understanding of mechanisms of disease pathogenesis. Thus current work in the laboratory is aimed at understanding triggers of intestinal inflammation and mechanisms of inflammation-associated neoplasia, in addition to developing novel therapies for IBD treatment. Ongoing research also includes investigating mechanisms that determine the immunogenicity of oral antigens, to develop novel adjuvants for oral vaccines. This work has relevance for pathogenesis and treatment of infectious diseases affecting the gastrointestinal tract, as well as for inflammatory bowel disease.

Dr. Hale is an expert in pathologic evaluation of colitis and immunodeficiency in both humans and mice and is board-certified in Anatomic and Clinical Pathology.

Current Appointments & Affiliations

Professor of Pathology, Pathology, Clinical Science Departments 2009
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2006

Contact Information

207A Davison Bldg, Durham, NC 27710
Duke Box 3712, Durham, NC 27710
laura.hale@duke.edu (919) 684-4771

Background
Education, Training, & Certifications
- Resident, Anatomic & Clinical Pathology, Pathology, Duke University 1991 - 1995
- M.D., Duke University 1991
- Ph.D., Duke University 1990
- M.S., Rutgers University 1984
- B.S., Michigan State University 1980
Duke Appointment History
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2009
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2007 - 2009
- Associate Research Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2007
- Assistant Research Professor of Pathology, Pathology, Clinical Science Departments 2003 - 2006
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 1995 - 2003
Research
Selected Grants
- Regulation of T cell metabolism and function by IRGM proteins awarded by National Institutes of Health 2019 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Core D: Human Translation and Verification awarded by University of Arizona 2017 - 2019
- Evaluating a Novel Therapy for Primary Sclerosing Cholangitis awarded by BHV Pharma 2016 - 2018
- Mechanisms Underlying Colorectal Cancer Risk in IBD (PQ6) awarded by National Institutes of Health 2012 - 2016
- RERF year 7 funding awarded by Radiation Effects Research Foundation 2009 - 2016
- Glucose uptake and metabolism in lymphocyte fate and inflammatory bowel disease awarded by Crohn's & Colitis Foundation of America, Inc. 2014 - 2015
- Chemoprevention of IBD-Associated Colon Cancer awarded by National Institutes of Health 2006 - 2011
- Mast Cells and IBD Pathogenesis awarded by National Institutes of Health 2006 - 2009
- Novel Oral Adjuvant for Dental Vaccines awarded by National Institutes of Health 2004 - 2008
- Bromelain Proteinase Activity in IBD awarded by National Institutes of Health 2005 - 2008
- Bromelain as a Biologically-Based Therapy for IBD awarded by National Institutes of Health 2004 - 2007
- Parathyroid and Thymus Transplants in DiGeorge Syndrome awarded by National Institutes of Health 2004 - 2006
- Genetics of Hereditary Hemorrhagic Telangiectasia awarded by National Institutes of Health 1993 - 2006
- B3 - Andrenoceptors and MAP kinase in Adipocytes awarded by National Institutes of Health 2000 - 2004
- Thymic Transplantation in Complete DiGeorge Syndrome awarded by National Institutes of Health 1999 - 2004
- Mechanisms of Age-Related Thymic Involution awarded by National Institutes of Health 1998 - 2001
- Viral Control And Immune Reconstitution In Hiv Infection awarded by National Institutes of Health 1996 - 1999
- Viral Control & Immune Reconstitution In Hiv Infection awarded by National Institutes of Health 1995 - 1999
- Mechanisms And Therapy Of Primary Immunodeficiency awarded by National Institutes of Health 1995 - 1999
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Spore In Breast Cancer awarded by National Institutes of Health 1995 - 1998
- Cd44 Isoforms And Human Breast Cancer Metastasis awarded by National Institutes of Health 1996 - 1998
- Cd44 Isoforms And Human Breast Cancer Metastasis awarded by National Institutes of Health 1993 - 1997
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Reese, AT, Pereira, FC, Schintlmeister, A, Berry, D, Wagner, M, Hale, LP, Wu, A, Jiang, S, Durand, HK, Zhou, X, Premont, RT, Diehl, AM, O'Connell, TM, Alberts, SC, Kartzinel, TR, Pringle, RM, Dunn, RR, Wright, JP, and David, LA. "Microbial nitrogen limitation in the mammalian large intestine." Nature Microbiology 3, no. 12 (December 2018): 1441-1450. Full Text
  - Ito, R, Hale, LP, Geyer, SM, Li, J, Sornborger, A, Kajimura, J, Kusunoki, Y, Yoshida, K, van den Brink, MRM, Kyoizumi, S, Manley, NR, Nakachi, K, and Sempowski, GD. "Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function." Radiation Research 187, no. 5 (May 2017): 589-598. Full Text
  - Liang, J, Huang, H-I, Benzatti, FP, Karlsson, AB, Zhang, JJ, Youssef, N, Ma, A, Hale, LP, and Hammer, GE. "Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88." Cell Reports 17, no. 5 (October 2016): 1330-1343. Full Text Open Access Copy
  - Hale, LP, Kant, EP, Greer, PK, and Foster, WM. "Retraction: Iron supplementation decreases severity of allergic inflammation in murine lung." Plos One 11, no. 5 (May 1, 2016). Full Text
  - Kajimura, J, Ito, R, Manley, NR, and Hale, LP. "Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues." The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society 64, no. 2 (February 2016): 112-124. Full Text
  - Hart, BE, Hale, LP, and Lee, S. "Immunogenicity and protection conferred by a recombinant Mycobacterium marinum vaccine against Buruli ulcer." Trials in Vaccinology 5 (2016): 88-91. Full Text
  - Nagy, E, Rodriguiz, RM, Wetsel, WC, MacIver, NJ, and Hale, LP. "Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease." PloS one 11, no. 4 (January 2016): e0152764-. Full Text Open Access Copy
  - Hart, BE, Hale, LP, and Lee, S. "Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer." Plos Neglected Tropical Diseases 9, no. 9 (September 22, 2015): e0004046-null. Full Text
  - Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of Clinical Investigation 125, no. 1 (January 2015): 194-207. Full Text Open Access Copy
  - Macintyre, AN, Gerriets, VA, Nichols, AG, Michalek, RD, Rudolph, MC, Deoliveira, D, Anderson, SM, Abel, ED, Chen, BJ, Hale, LP, and Rathmell, JC. "The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function." Cell Metabolism 20, no. 1 (July 2014): 61-72. Full Text
  - Hale, LP, Kant, EP, Greer, PK, and Foster, WM. "Correction: Iron supplementation decreases severity of allergic inflammation in murine lung (PLoS ONE)." Plos One 9, no. 1 (January 30, 2014). Full Text
  - Macintyre, AN, Gerriets, VA, Nichols, AG, Michalek, RD, Rudolph, MC, Deoliveira, D, Anderson, SM, Abel, ED, Chen, BJ, Hale, LP, and Rathmell, JC. "The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function." Cell Metabolism 20, no. 1 (2014): 61-72. Full Text
  - Karhausen, J, Qing, M, Gibson, A, Moeser, AJ, Griefingholt, H, Hale, LP, Abraham, SN, and Mackensen, GB. "Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest." Critical Care Medicine 41, no. 9 (September 2013): e200-e210. Full Text
  - Karhausen, J, Qing, M, Gibson, A, Moeser, AJ, Griefingholt, H, Hale, LP, Abraham, SN, and MacKensen, GB. "Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest." Critical Care Medicine 41, no. 9 (2013): e200-e210. Full Text
  - Kolstad, AM, Rodriguiz, RM, Kim, CJ, and Hale, LP. "Effect of pain management on immunization efficacy in mice." Journal of the American Association for Laboratory Animal Science : Jaalas 51, no. 4 (July 2012): 448-457.
  - Hale, LP, Kant, EP, Greer, PK, and Foster, WM. "Iron supplementation decreases severity of allergic inflammation in murine lung." PLoS One 7, no. 9 (2012): e45667-. Full Text Link to Item
  - Hale, LP, and Greer, PK. "A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features." PLoS One 7, no. 7 (2012): e41797-. Full Text Link to Item
  - Kolstad, AM, Kim, C, Rodriguiz, RM, and Hale, LP. "Effect of Pain Management on Immunization Efficacy in Mice." JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE 50, no. 5 (September 2011): 789-789. Link to Item
  - Hampton, DD, and Hale, LP. "Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam." PLoS One 6, no. 8 (2011): e23669-. Full Text Link to Item
  - Hale, LP, Chichlowski, M, Trinh, CT, and Greer, PK. "Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis." Inflamm Bowel Dis 16, no. 12 (December 2010): 2012-2021. Full Text Link to Item
  - Chichlowski, M, Westwood, GS, Abraham, SN, and Hale, LP. "Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice. (Published online)" PLoS One 5, no. 8 (August 17, 2010): e12220-. Full Text Open Access Copy Link to Item
  - Vanderford, DA, Greer, PK, Sharp, JM, Chichlowski, M, Rouse, DC, Selim, MA, and Hale, LP. "Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency." Exp Dermatol 19, no. 6 (June 2010): 518-526. Full Text Link to Item
  - Olofsson, LE, Olsson, B, Lystig, T, Jacobson, P, Jernås, M, Sjöholm, K, Gummesson, A, Sjöström, L, Eriksson, P, Hamsten, A, Hale, LP, Thelle, DS, Carlsson, B, and Carlsson, LMS. "Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids." Metabolism: Clinical and Experimental 59, no. 9 (2010): 1316-1318. Full Text
  - McGowen, AL, Hale, LP, Shelburne, CP, Abraham, SN, and Staats, HF. "The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen." Vaccine 27, no. 27 (June 2009): 3544-3552. Full Text
  - Ma, Q, Cavallin, LE, Yan, B, Zhu, S, Duran, EM, Wang, H, Hale, LP, Dong, C, Cesarman, E, Mesri, EA, and Goldschmidt-Clermont, PJ. "Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma." Proc Natl Acad Sci U S A 106, no. 21 (May 26, 2009): 8683-8688. Full Text Link to Item
  - Chichlowski, M, and Hale, LP. "Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies." Comparative Medicine 59, no. 1 (February 2009): 10-17. (Review)
  - Li, B, Li, J, Hsieh, C-S, Hale, LP, Li, Y-J, Devlin, BH, and Markert, ML. "Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes." Immunol Res 44, no. 1-3 (2009): 71-83. Full Text Link to Item
  - Chichlowski, M, Sharp, JM, Vanderford, DA, Myles, MH, and Hale, LP. "Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice." Comparative Medicine 58, no. 6 (December 2008): 534-541.
  - Chichlowski, M, and Hale, LP. "Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad." American Journal of Physiology. Gastrointestinal and Liver Physiology 295, no. 6 (December 2008): G1139-G1149. (Review) Full Text
  - Markert, ML, Devlin, BH, McCarthy, EA, Chinn, IK, and Hale, LP. "Thymus transplantation." (December 1, 2008): 255-267. (Chapter) Full Text
  - Sharp, JM, Vanderford, DA, Chichlowski, M, Myles, MH, and Hale, LP. "Helicobacter infection decreases reproductive performance of IL10-deficient mice." Comp Med 58, no. 5 (October 2008): 447-453. Link to Item
  - Fitzhugh, DJ, Shan, S, Dewhirst, MW, and Hale, LP. "Bromelain treatment decreases neutrophil migration to sites of inflammation." Clinical Immunology (Orlando, Fla.) 128, no. 1 (July 2008): 66-74. Full Text
  - Markert, ML, Li, J, Devlin, BH, Hoehner, JC, Rice, HE, Skinner, MA, Li, Y-J, and Hale, LP. "Use of allograft biopsies to assess thymopoiesis after thymus transplantation." Journal of Immunology (Baltimore, Md. : 1950) 180, no. 9 (May 2008): 6354-6364. Full Text
  - Chichlowski, M, Sharp, JM, Vanderford, DA, Myles, MH, and Hale, LP. "Effects of Helicobacter typhlonius and H. rodentium Infections in IL-10-deficient Mice." FASEB JOURNAL 22 (April 2008). Link to Item
  - Hale, LP, and Cianciolo, G. "Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription. (Published online)" J Inflamm (Lond) 5 (March 10, 2008): 4-. Full Text Link to Item
  - Onken, JE, Greer, PK, Calingaert, B, and Hale, LP. "Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro." Clinical Immunology (Orlando, Fla.) 126, no. 3 (March 2008): 345-352. Full Text
  - Hale, LP, Perera, D, Gottfried, MR, Maggio-Price, L, Srinivasan, S, and Marchuk, D. "Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice." Helicobacter 12, no. 6 (December 2007): 598-604. Full Text
  - Markert, ML, Devlin, BH, Alexieff, MJ, Li, J, McCarthy, EA, Gupton, SE, Chinn, IK, Hale, LP, Kepler, TB, He, M, Sarzotti, M, Skinner, MA, Rice, HE, and Hoehner, JC. "Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants." Blood 109, no. 10 (May 2007): 4539-4547. Full Text
  - Swidsinski, A, Göktas, O, Bessler, C, Loening-Baucke, V, Hale, LP, Andree, H, Weizenegger, M, Hölzl, M, Scherer, H, and Lochs, H. "Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis." Journal of Clinical Pathology 60, no. 3 (March 2007): 253-260. Full Text
  - Hale, LP, Fitzhugh, DJ, and Staats, HF. "Oral immunogenicity of the plant proteinase bromelain." International Immunopharmacology 6, no. 13-14 (December 2006): 2038-2046. Full Text
  - Plummer, NW, Squire, TL, Srinivasan, S, Huang, E, Zawistowski, JS, Matsunami, H, Hale, LP, and Marchuk, DA. "Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations." Mamm Genome 17, no. 2 (February 2006): 119-128. Full Text Link to Item
  - Hale, LP, Swidsinski, A, and Mendling, W. "Bacteria associated with bacterial vaginosis [1]." New England Journal of Medicine 354, no. 2 (2006): 202--. Full Text
  - Hale, LP, Gottfried, MR, and Swidsinski, A. "Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria." Inflamm Bowel Dis 11, no. 12 (December 2005): 1060-1069. Link to Item
  - Swidsinski, A, Mendling, W, Loening-Baucke, V, Ladhoff, A, Swidsinski, S, Hale, LP, and Lochs, H. "Adherent biofilms in bacterial vaginosis." Obstetrics and Gynecology 106, no. 5 Pt 1 (November 2005): 1013-1023. Full Text
  - Sempowski, GD, Hicks, CB, Eron, JJ, Bartlett, JA, Hale, LP, Ferrari, G, Edwards, LJ, Fiscus, S, and Haynes, BF. "Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function." Journal of Clinical Immunology 25, no. 5 (September 2005): 462-472. Full Text
  - Hale, LP, Greer, PK, Trinh, CT, and Gottfried, MR. "Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease." Clin Immunol 116, no. 2 (August 2005): 135-142. Full Text Link to Item
  - Swidsinski, A, Weber, J, Loening-Baucke, V, Hale, LP, and Lochs, H. "Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease." Journal of Clinical Microbiology 43, no. 7 (July 2005): 3380-3389. Full Text
  - Hale, LP, Greer, PK, Trinh, CT, and James, CL. "Proteinase activity and stability of natural bromelain preparations." Int Immunopharmacol 5, no. 4 (April 2005): 783-793. Full Text Link to Item
  - Swidsinski, A, Loening-Baucke, V, Lochs, H, and Hale, L-P. "Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice." World J Gastroenterol 11, no. 8 (February 28, 2005): 1131-1140. Link to Item
  - Swidsinski, A, Mendling, W, Loening-Baucke, V, Ladhoff, A, Swidsinski, S, Hale, LP, and Lochs, H. "Adherent biofilms in bacterial vaginosis." Obstetrics and Gynecology 106, no. 5 (January 1, 2005): 1013-1023. Full Text
  - Swidsinski, A, Mendling, W, Loening-Baucke, V, Ladhoff, A, Swidsinski, S, Hale, LP, and Lochs, H. "Adherent biofilms in bacterial vaginosis." Obstetrics and Gynecology 106, no. 5 I (2005): 1013-1023.
  - Swidsinski, A, Schlien, P, Pernthaler, A, Gottschalk, U, Bärlehner, E, Decker, G, Swidsinski, S, Strassburg, J, Loening-Baucke, V, Hoffmann, U, Seehofer, D, Hale, LP, and Lochs, H. "Bacterial biofilm within diseased pancreatic and biliary tracts." Gut 54, no. 3 (2005): 388-395. Full Text
  - Rice, HE, Skinner, MA, Mahaffey, SM, Oldham, KT, Ing, RJ, Hale, LP, and Markert, ML. "Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations." Journal of Pediatric Surgery 39, no. 11 (November 2004): 1607-1615. Full Text
  - Markert, ML, Alexieff, MJ, Li, J, Sarzotti, M, Ozaki, DA, Devlin, BH, Sedlak, DA, Sempowski, GD, Hale, LP, Rice, HE, Mahaffey, SM, and Skinner, MA. "Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome." Blood 104, no. 8 (October 2004): 2574-2581. Full Text
  - Madden, JF, Burchette, JL, and Hale, LP. "Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes." Hum Pathol 35, no. 5 (May 2004): 594-603. Link to Item
  - Markert, ML, Alexieff, MJ, Li, J, Sarzotti, M, Ozaki, DA, Devlin, BH, Sempowski, GD, Rhein, ME, Szabolcs, P, Hale, LP, Buckley, RH, Coyne, KE, Rice, HE, Mahaffey, SM, and Skinner, MA. "Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases." The Journal of Allergy and Clinical Immunology 113, no. 4 (April 2004): 734-741. Full Text
  - Hale, LP. "Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice." Int Immunopharmacol 4, no. 2 (February 2004): 255-264. Full Text Link to Item
  - Hale, LP. "Histologic and molecular assessment of human thymus." Ann Diagn Pathol 8, no. 1 (February 2004): 50-60. (Review) Link to Item
  - Hale, LP, Buckley, RH, Puck, JM, and Patel, DD. "Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiency." Clin Immunol 110, no. 1 (January 2004): 63-70. Full Text Link to Item
  - Hale, LP, and Markert, ML. "Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus." Journal of Immunology (Baltimore, Md. : 1950) 172, no. 1 (January 2004): 617-624. Full Text
  - Pham, TTN, Burchette, JL, and Hale, LP. "Fatal disseminated adenovirus infections in immunocompromised patients." Am J Clin Pathol 120, no. 4 (October 2003): 575-583. Full Text Link to Item
  - Markert, ML, Sarzotti, M, Ozaki, DA, Sempowski, GD, Rhein, ME, Hale, LP, Le Deist, F, Alexieff, MJ, Li, J, Hauser, ER, Haynes, BF, Rice, HE, Skinner, MA, Mahaffey, SM, Jaggers, J, Stein, LD, and Mill, MR. "Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients." Blood 102, no. 3 (August 2003): 1121-1130. Full Text
  - Srinivasan, S, Hanes, MA, Dickens, T, Porteous, MEM, Oh, SP, Hale, LP, and Marchuk, DA. "A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2." Hum Mol Genet 12, no. 5 (March 1, 2003): 473-482. Link to Item
  - Snyder, MJ, Bradford, WD, Kishnani, PS, and Hale, LP. "Idiopathic hyperammonemia following an unrelated cord blood transplant for mucopolysaccharidosis I." Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 6, no. 1 (January 2003): 78-83. Full Text
  - Flores, KG, McAllister, KA, Greer, PK, Wiseman, RW, and Hale, LP. "Thymic model for examining BRCA2 expression and function." Mol Carcinog 35, no. 3 (November 2002): 103-109. Full Text Link to Item
  - Hale, LP. "2C9 anti-BRCA2." HYBRIDOMA AND HYBRIDOMICS 21, no. 5 (October 2002): 399-399. Link to Item
  - Gilliam, LK, Lobenhofer, EK, Greer, PK, Scearce, RM, Cirisano, FD, Marks, JR, and Hale, LP. "BRCA2 monoclonal antibodies react with differentiating epithelium." Hybrid Hybridomics 21, no. 4 (August 2002): 261-269. Full Text Link to Item
  - Hale, LP, Greer, PK, and Sempowski, GD. "Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation." Clinical Immunology (Orlando, Fla.) 104, no. 2 (August 2002): 183-190. Full Text
  - Hale, LP. "Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes." J Invest Dermatol 119, no. 2 (August 2002): 464-470. Full Text Link to Item
  - Hale, LP, and Greer, PK. "Zinc alpha-2-glycoprotein contributes to tumor-associated thymic atrophy." CLINICAL IMMUNOLOGY 103, no. 3 (June 2002): S36-S37. Link to Item
  - Hale, LP, and Markert, ML. "Corticosteroids may regulate epithelial cell differentiation and Hassall body formation in the thymus." CLINICAL IMMUNOLOGY 103, no. 3 (June 2002): S36-S36. Link to Item
  - Markert, ML, Sarzotti, M, Ozaki, DA, Hale, LP, Alexieff, MA, and Li, J. "Thymus transplantation after immunosuppression with thymoglobulin." CLINICAL IMMUNOLOGY 103, no. 3 (June 2002): S88-S88. Link to Item
  - Markert, ML, Sarzotti, M, Ozaki, DA, Sempowski, GD, Rhein, ME, Hale, LP, Alexieff, MA, and Li, J. "Thymic transplantation in complete DiGeorge syndrome." Clinical Immunology 103, no. 3 (June 1, 2002): S77-S78. Link to Item
  - Hale, LP, Braun, RD, Gwinn, WM, Greer, PK, and Dewhirst, MW. "Hypoxia in the thymus: role of oxygen tension in thymocyte survival." American Journal of Physiology. Heart and Circulatory Physiology 282, no. 4 (April 2002): H1467-H1477. Full Text
  - Pan, L, Hanrahan, J, Li, J, Hale, LP, and Zhuang, Y. "An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus." Journal of Immunology (Baltimore, Md. : 1950) 168, no. 8 (April 2002): 3923-3932. Full Text
  - Pham, TTN, Burchette, JL, Henshaw, NG, and Hale, LP. "Fatal disseminated adenovirus infection in immunocompromised patients." LABORATORY INVESTIGATION 82, no. 1 (January 2002): 8A-8A. Link to Item
  - Pham, TTN, Burchette, JL, Henshaw, NG, and Hale, LP. "Fatal disseminated adenovirus infection in immunocompromised patients." MODERN PATHOLOGY 15, no. 1 (January 2002): 8A-8A. Link to Item
  - Markert, ML, Alvarez-McLeod, AP, Sempowski, GD, Hale, LP, Horvatinovich, JM, Weinhold, KJ, Bartlett, JA, D'Amico, TA, and Haynes, BF. "Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy." Aids Research and Human Retroviruses 17, no. 17 (November 2001): 1635-1643. Full Text
  - Flores, KG, Li, J, and Hale, LP. "B cells in epithelial and perivascular compartments of human adult thymus." Hum Pathol 32, no. 9 (September 2001): 926-934. Full Text Link to Item
  - Hale, LP, Clark, AG, Li, J, Greer, PK, and Byers Kraus, V. "Age-related thymic atrophy in the guinea pig." Dev Comp Immunol 25, no. 5-6 (June 2001): 509-518. Link to Item
  - Hale, LP, Price, DT, Sanchez, LM, Demark-Wahnefried, W, and Madden, JF. "Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer." Clin Cancer Res 7, no. 4 (April 2001): 846-853. Link to Item
  - Zhuang, Y, Pan, LH, Hanrahan, J, Li, J, Hale, LP, and Zheng, B. "E2A plays both T-lineage intrinsic and extrinsic roles in T cell development." FASEB JOURNAL 15, no. 5 (March 8, 2001): A1194-A1194. Link to Item
  - Sempowski, G, Thomasch, J, Gooding, M, Hale, L, Edwards, L, Ciafaloni, E, Sanders, D, Massey, J, Douek, D, Koup, R, and Haynes, B. "Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis." Journal of Immunology (Baltimore, Md. : 1950) 166, no. 4 (February 2001): 2808-2817. Full Text
  - Sampson, JH, Crotty, LE, Lee, S, Archer, GE, Ashley, DM, Wikstrand, CJ, Hale, LP, Small, C, Dranoff, G, Friedman, AH, Friedman, HS, and Bigner, DD. "Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors." Proceedings of the National Academy of Sciences of the United States of America 97, no. 13 (June 2000): 7503-7508. Full Text
  - Markert, ML, Hicks, CB, Bartlett, JA, Harmon, JL, Hale, LP, Greenberg, ML, Ferrari, G, Ottinger, J, Boeck, A, Kloster, AL, McLaughlin, TM, Bleich, KB, Ungerleider, RM, Lyerly, HK, Wilkinson, WE, Rousseau, FS, Heath-Chiozzi, ME, Leonard, JM, Haase, AT, Shaw, GM, Bucy, RP, Douek, DC, Koup, RA, Haynes, BF, Bolognesi, DP, and Weinhold, KJ. "Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection." Aids Research and Human Retroviruses 16, no. 5 (March 2000): 403-413. Full Text
  - Sempowski, GD, Hale, LP, Sundy, JS, Massey, JM, Koup, RA, Douek, DC, Patel, DD, and Haynes, BF. "Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy." Journal of Immunology (Baltimore, Md. : 1950) 164, no. 4 (February 2000): 2180-2187. Full Text
  - Haynes, BF, Markert, ML, Sempowski, GD, Patel, DD, and Hale, LP. "The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection." Annual Review of Immunology 18 (January 2000): 529-560. (Review) Full Text
  - Haynes, BF, Sempowski, GD, Wells, AF, and Hale, LP. "The human thymus during aging." Immunologic Research 22, no. 2-3 (January 2000): 253-261. (Review) Full Text
  - Flores, KG, Li, J, Sempowski, GD, Haynes, BF, and Hale, LP. "Analysis of the human thymic perivascular space during aging." The Journal of Clinical Investigation 104, no. 8 (October 1999): 1031-1039. Full Text
  - Markert, ML, Boeck, A, Hale, LP, Kloster, AL, McLaughlin, TM, Batchvarova, MN, Douek, DC, Koup, RA, Kostyu, DD, Ward, FE, Rice, HE, Mahaffey, SM, Schiff, SE, Buckley, RH, and Haynes, BF. "Transplantation of thymus tissue in complete DiGeorge syndrome." The New England Journal of Medicine 341, no. 16 (October 1999): 1180-1189. Full Text
  - Collard, HR, Boeck, A, Mc Laughlin, TM, Watson, TJ, Schiff, SE, Hale, LP, and Markert, ML. "Possible extrathymic development of nonfunctional T cells in a patient with complete DiGeorge syndrome." Clin Immunol 91, no. 2 (May 1999): 156-162. Full Text Link to Item
  - Haynes, BF, and Hale, LP. "Thymic function, aging, and AIDS." Hosp Pract (1995) 34, no. 3 (March 15, 1999): 59-passim. (Review) Link to Item
  - Haynes, BF, Hale, LP, Weinhold, KJ, Patel, DD, Liao, HX, Bressler, PB, Jones, DM, Demarest, JF, Gebhard-Mitchell, K, Haase, AT, and Bartlett, JA. "Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection." The Journal of Clinical Investigation 103, no. 4 (February 1999): 453-460. Full Text
  - Haynes, BF, and Hale, LP. "Corrigendum: The human thymus: A chimeric organ comprised of central and peripheral lymphoid components (Immunologic Research, 18, 3)." Immunologic Research 18, no. 3 (December 1, 1998): 175-192.
  - Lin, P, Buxton, JA, Acheson, A, Radziejewski, C, Maisonpierre, PC, Yancopoulos, GD, Channon, KM, Hale, LP, Dewhirst, MW, George, SE, and Peters, KG. "Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2." Proceedings of the National Academy of Sciences of the United States of America 95, no. 15 (July 1998): 8829-8834. Full Text
  - Ashley, DM, Sampson, JH, Archer, GE, Hale, LP, and Bigner, DD. "Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model." Journal of Neuroimmunology 86, no. 1 (June 1998): 46-52. Full Text
  - Lee, SE, Johnson, SP, Hale, LP, Li, J, Bullock, N, Fuchs, H, Friedman, A, McLendon, R, Bigner, DD, Modrich, P, and Friedman, HS. "Analysis of DNA mismatch repair proteins in human medulloblastoma." Clin Cancer Res 4, no. 6 (June 1998): 1415-1419. Link to Item
  - Slentz-Kesler, KA, Hale, LP, and Kaufman, RE. "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms." Genomics 47, no. 3 (February 1, 1998): 327-340. Full Text Link to Item
  - Ashley, DM, Kong, FM, Bigner, DD, and Hale, LP. "Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model." Cancer Research 58, no. 2 (January 1998): 302-309.
  - Haynes, BF, and Hale, LP. "The human thymus. A chimeric organ comprised of central and peripheral lymphoid components." Immunologic Research 18, no. 2 (January 1998): 61-78. (Review) Full Text
  - Haynes, BF, and Hale, LP. "The human thymus. A chimeric organ comprised of central and peripheral lymphoid components." Immunologic Research 18, no. 3 (January 1998): 175-192. (Review) Full Text
  - Sampson, JH, Ashley, DM, Archer, GE, Fuchs, HE, Dranoff, G, Hale, LP, and Bigner, DD. "Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion." Neurosurgery 41, no. 6 (December 1997): 1365-1372. Full Text
  - Ashley, DM, Faiola, B, Nair, S, Hale, LP, Bigner, DD, and Gilboa, E. "Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors." J Exp Med 186, no. 7 (October 6, 1997): 1177-1182. Link to Item
  - Ashley, DM, Sampson, JH, Archer, GE, Batra, SK, Bigner, DD, and Hale, LP. "A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo." Journal of Neuroimmunology 78, no. 1-2 (September 1997): 34-46. Full Text
  - Liu, NP, Roberts, WL, Hale, LP, Levesque, MC, Patel, DD, Lu, CL, and Jaffe, GJ. "Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells." Investigative Ophthalmology & Visual Science 38, no. 10 (September 1997): 2027-2037.
  - Hale, LP. "Not a "bee-zoar," but a wasp." N Engl J Med 337, no. 8 (August 21, 1997): 575-. (Letter) Full Text Link to Item
  - Tang, ML, Hale, LP, Steeber, DA, and Tedder, TF. "L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice." Journal of Immunology (Baltimore, Md. : 1950) 158, no. 11 (June 1997): 5191-5199.
  - Davis, CM, McLaughlin, TM, Watson, TJ, Buckley, RH, Schiff, SE, Hale, LP, Haynes, BF, and Markert, ML. "Normalization of the peripheral blood T cell receptor V beta repertoire after cultured postnatal human thymic transplantation in DiGeorge syndrome." J Clin Immunol 17, no. 2 (March 1997): 167-175. Link to Item
  - Markert, ML, Kostyu, DD, Ward, FE, McLaughlin, TM, Watson, TJ, Buckley, RH, Schiff, SE, Ungerleider, RM, Gaynor, JW, Oldham, KT, Mahaffey, SM, Ballow, M, Driscoll, DA, Hale, LP, and Haynes, BF. "Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus." J Immunol 158, no. 2 (January 15, 1997): 998-1005. Link to Item
  - Markert, ML, Watson, TJ, Kaplan, I, Hale, LP, and Haynes, BF. "The human thymic microenvironment during organ culture." Clinical Immunology and Immunopathology 82, no. 1 (January 1997): 26-36. Full Text
  - Tang, MLK, Hale, LP, Steeber, DA, and Tedder, TF. "Role of L-selectin in lymphocyte migration to cutaneous sites of inflammation." JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 99, no. 1 (January 1997): 1729-1729. Link to Item
  - Sampson, JH, Archer, GE, Ashley, DM, Fuchs, HE, Hale, LP, Dranoff, G, and Bigner, DD. "Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system." Proceedings of the National Academy of Sciences of the United States of America 93, no. 19 (September 1996): 10399-10404. Full Text
  - Markert, ML, Davis, CM, Ward, FE, Kostyu, DD, Buckley, RH, Schiff, SE, Watson, TJ, McLaughlin, TM, Hale, LP, Ballow, M, and Haynes, BF. "Thymic transplantation for digeorge syndrome." FASEB JOURNAL 10, no. 6 (April 30, 1996): 373-373. Link to Item
  - Liu, NP, Roberts, WL, Hale, LP, Greer, PK, Levesque, M, Patel, DD, Lu, CL, and Jaffe, GJ. "Expression and density-dependent regulation of CD44 and variant isoforms in cultured human retinal pigment epithelium cells." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 37, no. 3 (February 15, 1996): 1798-1798. Link to Item
  - Hale, LP, Patel, DD, Clark, RE, and Haynes, BF. "Distribution of CD44 variant isoforms in human skin: differential expression in components of benign and malignant epithelia." Journal of Cutaneous Pathology 22, no. 6 (December 1995): 536-545. Full Text
  - Hale, LP, Haynes, BF, and McCachren, SS. "Expression of CD44 variants in human inflammatory synovitis." J Clin Immunol 15, no. 6 (November 1995): 300-311. Link to Item
  - MARKERT, ML, WATSON, TJ, MCLAUGHLIN, TM, MCGUIRE, CA, WARD, FE, KOSTYU, D, HALE, LP, BUCKLEY, RH, SCHIFF, SE, BLEESING, JJH, BROOME, CB, UNGERLEIDER, RM, MAHAFFEY, SM, OLDHAM, KT, and HAYNES, BF. "DEVELOPMENT OF T-CELL FUNCTION AFTER POSTNATAL THYMIC TRANSPLANTATION FOR DIGEORGE-SYNDROME." AMERICAN JOURNAL OF HUMAN GENETICS 57, no. 4 (October 1995): 64-64. Link to Item
  - Wikstrand, CJ, Hale, LP, Batra, SK, Hill, ML, Humphrey, PA, Kurpad, SN, McLendon, RE, Moscatello, D, Pegram, CN, and Reist, CJ. "Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas." Cancer Research 55, no. 14 (July 1995): 3140-3148.
  - Hale, LP, van de Ven, CJ, Wenger, DA, Bradford, WD, and Kahler, SG. "Infantile sialic acid storage disease: a rare cause of cytoplasmic vacuolation in pediatric patients." Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated With the International Paediatric Pathology Association 15, no. 3 (May 1995): 443-453. (Review) Full Text
  - Patel, DD, Hale, LP, Whichard, LP, Radcliff, G, Mackay, CR, and Haynes, BF. "Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated." International Immunology 7, no. 2 (February 1995): 277-286. Full Text
  - Wentworth, PA, Celis, E, Crimi, C, Stitely, S, Hale, L, Tsai, V, Serra, HM, Guercio, M-FD, Livingston, B, Alazard, D, Fikes, J, Kubo, RT, Grey, HM, Chesnut, RW, Chisari, FV, and Sette, A. "In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides." Molecular Immunology 32, no. 9 (1995): 603-612.
  - HALE, LP, MCKAY, CR, HAYNES, BF, and MCCACHREN, SS. "SYNOVIAL LINING MACROPHAGES IN RHEUMATOID-ARTHRITIS PREFERENTIALLY EXPRESS SPECIFIC CD44-VARIANT ISOFORMS COMPARED TO OTHER TISSUE MACROPHAGES." BLOOD 82, no. 10 (November 15, 1993): A32-A32. Link to Item
  - Hale, LP, and Haynes, BF. "Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation." J Immunol 149, no. 12 (December 15, 1992): 3809-3816. Link to Item
  - Haynes, BF, Hale, LP, Patton, KL, Martin, ME, and McCallum, RM. "Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis." Arthritis and Rheumatism 34, no. 11 (November 1991): 1434-1443.
  - Hale, LP, Singer, KH, and Haynes, BF. "CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells." Journal of Immunology (Baltimore, Md. : 1950) 143, no. 12 (December 1989): 3944-3948.
  - Haynes, BF, Telen, MJ, Hale, LP, and Denning, SM. "CD44--a molecule involved in leukocyte adherence and T-cell activation." Immunol Today 10, no. 12 (December 1989): 423-428. (Review) Full Text Link to Item
  - Hale, LP, Martin, ME, McCollum, DE, Nunley, JA, Springer, TA, Singer, KH, and Haynes, BF. "Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment." Arthritis and Rheumatism 32, no. 1 (January 1989): 22-30. Full Text
  - Haynes, BF, Hale, LP, Denning, SM, Le, PT, and Singer, KH. "The role of leukocyte adhesion molecules in cellular interactions: implications for the pathogenesis of inflammatory synovitis." Springer Seminars in Immunopathology 11, no. 2 (January 1989): 163-185. (Review) Full Text
  - Haynes, BF, Grover, BJ, Whichard, LP, Hale, LP, Nunley, JA, McCollum, DE, and Singer, KH. "Synovial microenvironment-T cell interactions. Human T cells bind to fibroblast-like synovial cells in vitro." Arthritis and Rheumatism 31, no. 8 (August 1988): 947-955. Full Text
  - HALE, LP, GROVER, BJ, MARTIN, ME, WHICHARD, LP, SINGER, KH, and HAYNES, BF. "SYNOVIAL CELL-T CELL-INTERACTIONS IN INFLAMMATORY SYNOVITIS - STUDY OF THE ROLE OF THE CD2-LFA-3 ADHESION PATHWAY." CLINICAL RESEARCH 36, no. 3 (April 1988): A532-A532. Link to Item
  - Hale, LP, Braun, RD, Gwinn, WM, Greer, PK, and Dewhirst, MW. "Hypoxia in the thymus: Role of oxygen tension in thymocyte survival." American Journal of Physiology Heart and Circulatory Physiology 282, no. 4 51-4 (June 29, 2002).
- Other Articles
  - Haynes, BF, Hale, LP, Weinhold, KJ, Patel, DD, Liao, HX, Bressler, PB, Jones, DM, Demarest, JF, Gebhard-Mitchell, K, Haase, AT, and Bartlett, JA. "Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection." J Clin Invest 103, no. 6 (March 15, 1999): 921-. Link to Item
  - Haynes, BF, Hale, LP, Weinhold, KJ, Patel, DD, Liao, HX, Bressler, PB, Jones, DM, Demarest, JF, Gebhard-Mitchell, K, Haase, AT, and Bartlett, JA. "Erratum: Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection (The Journal of Clinical Investigation (1999) 103 (453- 460))." Journal of Clinical Investigation 103, no. 6 (March 15, 1999): 921-null.
- Conference Papers
  - Hayashi, T, Lynch, HE, Geyer, S, Yoshida, K, Furudoi, K, Sasaki, K, Morishita, Y, Nagamura, H, Maki, M, Hu, Y, Hayashi, I, Kyoizumi, S, Kusunoki, Y, Ohishi, W, Fujiwara, S, Misumi, M, Shterev, I, Nikolich-Žugich, J, Murasko, D, Hale, LP, Sempowski, GD, and Nakachi, K. "Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort." October 2018. Full Text
  - Hammer, G, Liang, J, Huang, H-I, Benzatti, F, Karlsson, A, and Hale, LP. "Microbiota upregulate distinct APC functions in each intestinal dendritic cell subset, in a Myd88-independent fashion." May 1, 2016. Link to Item
  - Hale, LP, Gottfried, MR, and Onken, JE. "Bromelain treatment of inflammatory bowel disease." April 2004. Link to Item
  - Pham, TTN, Burchette, JL, and Hale, LP. "Fatal disseminated adenovirus infections in immunocompromised patients." October 2003. Full Text
  - Hale, LP. "Thymic microenvironment abnormalities in X-linked severe combined immunodeficiency syndrome." October 2002. Link to Item
  - Srinivasan, S, Dickens, T, Hale, LP, and Marchuk, DA. "A murine model for hereditary hemorrhagic telangiectasia type 2." October 2002. Link to Item
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